CN106138574A - A kind of Chinese medicine composition of expectorant spleen invigorating and preparation method thereof - Google Patents
A kind of Chinese medicine composition of expectorant spleen invigorating and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The present invention relates to Chinese medicine composition of a kind of expectorant spleen invigorating and preparation method thereof.This Chinese medicine is prepared from by raw material of Chinese medicine such as Fructus Aurantii Immaturus, Semen Sinapis Albae, Radix Stephaniae Tetrandrae, Semen Armeniacae Amarum, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Arecae, Semen Arecae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulataes.Present invention also offers the preparation method of this Chinese medicine composition.The Chinese medicine composition expectorant spleen invigorating that the present invention provides, is mainly used in treating insufficiency of the spleen abundant expectoration type fat.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of expectorant spleen invigorating and preparation method thereof.
Background technology
Along with economic development and the raising of living standards of the people, the obese people of obese patient, especially city has year by year
The trend increased, wherein Simple Obesity accounts for more than the 95% of overweight people.In traditional Chinese medical science angle, Simple Obesity should be regarded as machine
The imbalance state of body, belongs to shape and contains the deficiency of vital energy, and shape is definitely had a surplus and gas relative deficiency, and mainly health preserving is improper caused, it is also possible to
Body malfunction is relevant.
Huangdi's Internal Classics is divided into " cream people ", " fat people " and " meat people " obesity, and obesity is divided into " fat with modern medicine
Type, lean meat species, edema type " similar.Cream people, it is seen that " vertical abdomen hangs down fertile ", " skin delays ", belong to the obesity that stomach fat is many；Fat people, can
See " though fat can not be greatly ", " meat hard, skin is full ", this type obesity but well-balanced；Meat people, it is seen that " skin and flesh not from ", " health holds
Greatly ", the hypertrophy with muscle shows for main.
Forming fat cause of disease complexity various, existing natural endowment factor, again with eating and drinking without temperance, the uneven allocation of work, disorder of emotion, disease
The acquired dispositions such as disease, medicine are closely related." the very sick opinion of Plain Questions " is said: " must count the sweet and refreshing and many fertilizer of food also.", " face card guide doctor
Case " say that " fat meat and fine grain wine sweet wine is excessive, or too many addicted to soup of drinking tea, or eats raw food melon and fruit and sweet greasy thing.Its people color Bai Erfei, muscle is soft
Soft ", " inspection abide by through " is said: " wealth and rank person, health is soft crisp, and skin is fertile white, at edge between boudoir's spacious mansion." obesity is caused a disease
Factor, the traditional Chinese medical science thinks, the pathogenic factor in close relations with obesity, mainly expectorant, the stasis of blood, water, wet etc..
In the traditional Chinese medical science, it is all obese patient, but everyone body constitution is different.Fat people's red complexion of having, xerostomia, just
Secret, like to eat cool, illustrate internal have wet, have fire, belong to damp and hot stagnant spleen type, need to reduce internal heat, damp eliminating, spleen invigorating；The fat people face having has
The confused weight of glossy, brains, abundant expectoration, nausea and vomiting, abdominal distention uncomfortable in chest, belong to the turbid interior Sheng type of expectorant, need expectorant diuretic, spleen invigorating alleviating distention in middle-JIAO；Have
Fat people mainly show as breathing hard, weak, abdominal distention, be afraid of cold, like that perspiration etc., metabolism weaken, belong to yang deficiency of spleen and stomache, treatment
On then need spleen invigorating, the kidney invigorating, warming YANG.
Summary of the invention
It is an object of the invention to provide the Chinese medicine composition of a kind of expectorant spleen invigorating；
It is a further object of the present invention to provide the preparation method of the Chinese medicine composition of a kind of expectorant spleen invigorating.
It is an object of the invention to by following technical scheme realization:
The Chinese medicine composition of expectorant spleen invigorating of the present invention, is to be prepared from by the raw material of Chinese medicine of following weight portion:
Fructus Aurantii Immaturus 30-50 part, Semen Sinapis Albae 10-30 part, Radix Stephaniae Tetrandrae 10-30 part, Semen Armeniacae Amarum 5-20 part, Rhizoma Atractylodis Macrocephalae 30-50 part, Poria 30-50 part,
Pericarpium Arecae 10-30 part, Semen Arecae 5-20 part, Cortex Magnoliae Officinalis 10-30 part, Pericarpium Citri Reticulatae 10-30 part.
Preferably, it is to be prepared from by the raw material of Chinese medicine of following weight portion:
Fructus Aurantii Immaturus 35-45 part, Semen Sinapis Albae 15-25 part, Radix Stephaniae Tetrandrae 15-25 part, Semen Armeniacae Amarum 10-15 part, Rhizoma Atractylodis Macrocephalae 35-45 part, Poria 35-45
Part, Pericarpium Arecae 15-25 part, Semen Arecae 10-15 part, Cortex Magnoliae Officinalis 15-25 part, Pericarpium Citri Reticulatae 15-25 part.
The following is the crude drug source of Chinese medicine preparation of the present invention:
Fructus Aurantii Immaturus, for rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof or Fructus Citri sinensis Citrus
The dry young fruit of sinensis Osbeck.[nature and flavor] are bitter, pungent, sour, temperature.[return through] returns spleen, stomach warp.[function cures mainly] dispelling the stagnated QI disappears
Long-pending, scattered painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, weight, constipation, the expectorant stagnant vapour lock thoracic obstruction, blocked-up chest after dysentery；Gastroptosis,
Proctoptosis, uterine prolapse.
Semen Sinapis Albae, for the seed of crucifer Caulis et Folium Sinapis albee.[nature and flavor] are pungent, temperature.[return through] enters lung, stomach warp.[function master
Control] promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Controlling phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, limbs
Arthralgia pain is numb, tinea pedis, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Radix Stephaniae Tetrandrae, for the dry root of menispermaceous plants Radix stephaniae tetrandrae Stephania tetrandra S. Moore.[nature and flavor] are bitter,
Cold.[return through] returns bladder, lung meridian.[function cures mainly] inducing diuresis to remove edema, wind-expelling pain-stopping.For edema tinea pedis, dysuria, eczema skin ulcer
Poison, rheumatic arthralgia；Hypertension.
Semen Armeniacae Amarum, for the dry seed of the bitter in the mouth such as rosaceous plant Fructus Pruni or Prunus armeniaca L.var.ansu Maxim..[nature and flavor] are bitter, temperature, poisonous.[return through] enters
Lung, large intestine channel.[function cures mainly] expelling phlegm for arresting cough, relievings asthma, intestine moistening.Control exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.
The Rhizoma Atractylodis Macrocephalae, for the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..[nature and flavor]
Bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite,
Abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Poria, for the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.[nature and flavor] sweet,
Light, flat.[return through] GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention is dizzy
Throbbing with fear, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.
Pericarpium Arecae, for the dry peel of babassu Semen Arecae Areca catechu L..[nature and flavor] are pungent, tepor.[return
Warp] return spleen, stomach, large intestine, small intestine meridian.[function cures mainly] therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, stool
Not well, edema distension, beriberi edema, dysuria.
Semen Arecae, for the dry mature seed of babassu Semen Arecae Areca catechu L..[nature and flavor] are bitter, pungent, temperature.
[return through] returns stomach, large intestine channel.[function cures mainly] killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, worm
Long-pending stomachache, stagnant dysentery, tenesmus, edema tinea pedis, malaria.
Cortex Magnoliae Officinalis, for Magnoliacea plant Cortex Magnoliae Officinalis Magnolia officinalis Rehd. et Wils. or magnolia officinalis rehd.et wils.var.biloba rehd.et wils.
The dry dried bark of Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils., root bark
And branch skin.[nature and flavor] are bitter, pungent, temperature.[return through] returns spleen, stomach, lung, large intestine channel.[function cures mainly] dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.With
In humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Pericarpium Citri Reticulatae, for the drying and ripening fruit of rutaceae orange Citrus reticulata Blanco and variety thereof
Skin.[nature and flavor] are bitter, pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, food
Few vomiting and diarrhoea, cough with copious phlegm.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is
Use water to carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.Concrete preparation method is as follows:
Scheme one: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight,
Extraction time is 1-3 hour every time, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20
Clear paste, obtain active component.
Scheme two: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material total amount
4-10 times, extraction time is 1-4 hour, united extraction liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is
1.15-1.20 clear paste, obtain active component.
Scheme three: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-of medical material gross weight
12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
The clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80
DEG C time relative density be the extractum of 1.10-1.25, obtain active component.
The Chinese medicine composition of expectorant spleen invigorating of the present invention, it is also possible to pharmaceutically acceptable carrier combination, system
Become various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture etc..
The pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc..
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc..
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc..
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, vegetable oil etc..
Correctives: sucrose, monosaccharide, aromatic etc..
Preservative: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc..
Method 1: tablet
Taking one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into this routinely
Invention tablet.
Above-mentioned tablet is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Taking one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into routinely
Capsule of the present invention.
Above-mentioned capsule is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Taking one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into routinely
Syrup of the present invention.
Above-mentioned syrup is commonly used adjuvant and is included one of correctives, preservative, cosolvent or whole.
Method 4: mixture
Taking one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into this routinely
Invention mixture.
Above-mentioned mixture is commonly used adjuvant and is included one of correctives, preservative or whole.
Method 5: oral liquid
Take one of scheme one to scheme three gained active component, dissolve after-purification, concentration, add oral liquid and commonly use adjuvant, by often
Rule production method is prepared into oral liquid of the present invention.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
The Chinese medicine composition of a kind of expectorant spleen invigorating that the present invention provides has the advantage that
1, the Chinese medicine composition of the expectorant spleen invigorating that the present invention provides is safe and effective, has invigorating the spleen to clear away damp pathogen, effect of expectorant diuretic, right
Insufficiency of the spleen abundant expectoration type obesity total effective rate is 86.57%.
3, Traditional Chinese medicine composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating
The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention
Claimed scope.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
Embodiment 1 granule
Weigh Fructus Aurantii Immaturus 30g, Semen Sinapis Albae 10g, Radix Stephaniae Tetrandrae 10g, Semen Armeniacae Amarum 5g, Rhizoma Atractylodis Macrocephalae 30g, Poria 30g, Pericarpium Arecae 10g, Semen Arecae 5g, thickness
Piao 10g, Pericarpium Citri Reticulatae 10g.Extracting in water 3 times, three times amount of water is respectively 12 times of medical material gross weight, 8 times, 6 times, when extracting for three times
Between be respectively 3 hours, 2 hours, 1 hour, united extraction liquid, filter, when filtrate is concentrated into 70 DEG C relative density be 1.25 clear
Cream, adds starch, dextrin, pelletizes, is dried, granulate and get final product.
Embodiment 2 tablet
Weigh Fructus Aurantii Immaturus 50g, Semen Sinapis Albae 30g, Radix Stephaniae Tetrandrae 30g, Semen Armeniacae Amarum 20g, Rhizoma Atractylodis Macrocephalae 50g, Poria 50g, Pericarpium Arecae 30g, Semen Arecae 20g,
Cortex Magnoliae Officinalis 30g, Pericarpium Citri Reticulatae 30g.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, and each ethanol consumption is respectively
For 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, united extraction liquid, filters, and filtrate is concentrated into 80 DEG C
Time relative density be the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, prepare tablet.
Embodiment 3 tablet
Weigh Fructus Aurantii Immaturus 35g, Semen Sinapis Albae 15g, Radix Stephaniae Tetrandrae 15g, Semen Armeniacae Amarum 10g, Rhizoma Atractylodis Macrocephalae 35g, Poria 35g, Pericarpium Arecae 15g, Semen Arecae 10g,
Cortex Magnoliae Officinalis 15g, Pericarpium Citri Reticulatae 15g.Extracting in water 3 times, three times amount of water is respectively equivalent to 12 times of medical material gross weight, 8 times, 6 times, every time
3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is 1.20
Clear paste, add ethanol, making alcohol content is 40%, stands 24 hours, filtration, filtrate is concentrated into filtrate and is concentrated into when 70 DEG C relative
Density is the extractum of 1.10, adds supplementary product starch, ethanol, Pulvis Talci, prepares tablet.
Embodiment 4 capsule
Weigh Fructus Aurantii Immaturus 45g, Semen Sinapis Albae 25g, Radix Stephaniae Tetrandrae 25g, Semen Armeniacae Amarum 15g, Rhizoma Atractylodis Macrocephalae 45g, Poria 45g, Pericarpium Arecae 25g, Semen Arecae 15g,
Cortex Magnoliae Officinalis 25g, Pericarpium Citri Reticulatae 25g.With 40% alcohol reflux 3 times, each ethanol consumption be respectively 10 times of medical material total amount, 8 times, 4
Times, 3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, to filter, when filtrate concentrates 60 DEG C, relative density is 1.25
Extractum, in extractum add supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method.
Embodiment 5 granule
Weigh Fructus Aurantii Immaturus 40g, Semen Sinapis Albae 20g, Radix Stephaniae Tetrandrae 20g, Semen Armeniacae Amarum 12g, Rhizoma Atractylodis Macrocephalae 40g, Poria 40g, Pericarpium Arecae 20g, Semen Arecae 12g,
Cortex Magnoliae Officinalis 20g, Pericarpium Citri Reticulatae 20g.Extracting in water 2 times, each amount of water is respectively equivalent to 12 times of medical material gross weight, 10 times, carries every time
The time of taking is respectively 3 hours, 2 hours, united extraction liquid, filters, and it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C,
Adding ethanol, making alcohol content is 70%, stands 12 hours, filters, and when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25,
Add starch, dextrin, pelletize, be dried, granulate and get final product.
Embodiment 6 syrup
Weigh Fructus Aurantii Immaturus 32g, Semen Sinapis Albae 12g, Radix Stephaniae Tetrandrae 12g, Semen Armeniacae Amarum 8g, Rhizoma Atractylodis Macrocephalae 32g, Poria 32g, Pericarpium Arecae 12g, Semen Arecae 8g, thickness
Piao 12g, Pericarpium Citri Reticulatae 12g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, and twice extraction time divides
It is not 2 hours, 1 hour, united extraction liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum
Addition syrup adjuvant sucrose, sorbic acid, water stir, and prepare syrup.
Embodiment 7 oral liquid
Weigh Fructus Aurantii Immaturus 38g, Semen Sinapis Albae 18g, Radix Stephaniae Tetrandrae 18g, Semen Armeniacae Amarum 11g, Rhizoma Atractylodis Macrocephalae 38g, Poria 38g, Pericarpium Arecae 18g, Semen Arecae 11g,
Cortex Magnoliae Officinalis 18g, Pericarpium Citri Reticulatae 18g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, twice extraction time
Being respectively 2 hours, 1 hour, united extraction liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, at extractum
Middle addition adjuvant mannitol, sorbic acid, water stir, subpackage, prepare oral liquid.
Embodiment 8 mixture
Weigh Fructus Aurantii Immaturus 42g, Semen Sinapis Albae 23g, Radix Stephaniae Tetrandrae 23g, Semen Armeniacae Amarum 14g, Rhizoma Atractylodis Macrocephalae 42g, Poria 42g, Pericarpium Arecae 23g, Semen Arecae 14g,
Cortex Magnoliae Officinalis 23g, Pericarpium Citri Reticulatae 23g.Extracting in water 3 times, three times amount of water is respectively equivalent to 12 times of medical material gross weight, 8 times, 6 times, every time
3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, filter, filtrate is concentrated into 3 that gross weight is medical material gross weight
Times, fill, addition mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, and prepare mixture.
Embodiment 9 powder
Weigh Fructus Aurantii Immaturus 48g, Semen Sinapis Albae 28g, Radix Stephaniae Tetrandrae 28g, Semen Armeniacae Amarum 18g, Rhizoma Atractylodis Macrocephalae 48g, Poria 48g, Pericarpium Arecae 28g, Semen Arecae 18g,
Cortex Magnoliae Officinalis 28g, Pericarpium Citri Reticulatae 28g.Pulverize, sieve, to obtain final product.
Embodiment 10
Granule prepared by the embodiment of the present invention 5, gives insufficiency of the spleen abundant expectoration type obese patient and is administered orally, and each 20g three times a day, faces
Bed data are as follows:
| Disorder class | Disease number of cases | Disease year calendar | Treatment time | Efficiently individual quantity | Total effective rate |
| Insufficiency of the spleen abundant expectoration type is fat | 67 | 1-6 | 30 days-1 year | 58 people | 86.57% |
Embodiment 11
Lee, man, 32 years old.Body is good at ordinary times, on ordinary days likes eating wheaten food, the product of happiness delicious food, and hobby is drunk, and over nearly 2 years, body weight increases
Too fast, to feel weak gradually, breathe hard, dynamic the most dripping with perspiration, extremity are sleepy, and thin white fur of tongue is greasy, stringy and thready pulse, height 168cm, body weight
88kg, abdominal circumference 107cm, Abdominal Wall Fat thickness is 59mm.Card belongs to spleen insufficiency, tired in phlegm-damp.Give the embodiment of the present invention 2 to control
Treat, and be careful in one's diet structural adjustment and physical fitness training, continuously, to check after 2 months, tired transference cure, cardiopalmus symptom alleviates, food
Amount reduces about 1/2 than in the past, and tongue pulse condition is without significant change, and body weight reduces to 80kg, declines 8kg, and abdominal circumference reduces 5cm, Abdominal Wall Fat
Thickness is down to 47mm, declines 12mm.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching
Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (7)
1. the Chinese medicine composition of an expectorant spleen invigorating, it is characterised in that it is to be prepared from by the raw material of Chinese medicine of following weight portion
:
Fructus Aurantii Immaturus 30-50 part, Semen Sinapis Albae 10-30 part, Radix Stephaniae Tetrandrae 10-30 part, Semen Armeniacae Amarum 5-20 part, Rhizoma Atractylodis Macrocephalae 30-50 part, Poria 30-50 part,
Pericarpium Arecae 10-30 part, Semen Arecae 5-20 part, Cortex Magnoliae Officinalis 10-30 part, Pericarpium Citri Reticulatae 10-30 part.
2. the Chinese medicine composition of expectorant spleen invigorating as claimed in claim 1, it is characterised in that it is by including following weight portion
Raw material of Chinese medicine is prepared from:
Fructus Aurantii Immaturus 35-45 part, Semen Sinapis Albae 15-25 part, Radix Stephaniae Tetrandrae 15-25 part, Semen Armeniacae Amarum 10-15 part, Rhizoma Atractylodis Macrocephalae 35-45 part, Poria 35-45
Part, Pericarpium Arecae 15-25 part, Semen Arecae 10-15 part, Cortex Magnoliae Officinalis 15-25 part, Pericarpium Citri Reticulatae 15-25 part.
3. the Chinese medicine composition of expectorant spleen invigorating as claimed in claim 1 or 2, it is characterised in that its active component is to use water
Carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.
4. the Chinese medicine composition of expectorant spleen invigorating as claimed in claim 3, it is characterised in that its active component is by following
Method is prepared from: take whole medical material, extracting in water 2-3 time after mixing, and each amount of water is equivalent to the 6-of medical material gross weight
12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
1.15-1.20 clear paste, obtain active component.
5. the Chinese medicine composition of expectorant spleen invigorating as claimed in claim 3, it is characterised in that its active component is by following
Method is prepared from: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material
4-10 times of total amount, extraction time is 1-4 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
1.15-1.20 clear paste, obtain active component.
6. the Chinese medicine composition of expectorant spleen invigorating as claimed in claim 3, it is characterised in that its active component is by following
Method is prepared from: take whole medical material, extracting in water 2-3 time after mixing, and each amount of water is equivalent to the 6-of medical material gross weight
12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-
The clear paste of 1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80 DEG C of phase
It is the extractum of 1.10-1.25 to density, obtains active component.
7. a preparation for expectorant spleen invigorating, by the Chinese medicine composition of the expectorant spleen invigorating described in claim 1-6 and pharmaceutically may be used
The carrier combination accepted is prepared from.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100820A (en) * | 2009-12-18 | 2011-06-22 | 杨红 | Soup capable of dissolving phlegm and tonifying spleen |
| CN103520644A (en) * | 2013-10-18 | 2014-01-22 | 李佃场 | Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition |
| CN103768310A (en) * | 2012-10-24 | 2014-05-07 | 魏自由 | Weight-reducing traditional Chinese medicine composition |
-
2016
- 2016-08-17 CN CN201610676363.6A patent/CN106138574A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100820A (en) * | 2009-12-18 | 2011-06-22 | 杨红 | Soup capable of dissolving phlegm and tonifying spleen |
| CN103768310A (en) * | 2012-10-24 | 2014-05-07 | 魏自由 | Weight-reducing traditional Chinese medicine composition |
| CN103520644A (en) * | 2013-10-18 | 2014-01-22 | 李佃场 | Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition |
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Application publication date: 20161123 |