CN106132967B - 作为ros1抑制剂的化合物 - Google Patents
作为ros1抑制剂的化合物 Download PDFInfo
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- CN106132967B CN106132967B CN201580016427.3A CN201580016427A CN106132967B CN 106132967 B CN106132967 B CN 106132967B CN 201580016427 A CN201580016427 A CN 201580016427A CN 106132967 B CN106132967 B CN 106132967B
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 87
- -1 cyano, amino Chemical group 0.000 claims description 79
- 125000001424 substituent group Chemical group 0.000 claims description 79
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 48
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- C—CHEMISTRY; METALLURGY
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| EP14161959.3 | 2014-03-27 | ||
| EP14161959 | 2014-03-27 | ||
| PCT/EP2015/056501 WO2015144801A1 (en) | 2014-03-27 | 2015-03-26 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND 2,3-DIHYDRO-1H-IMIDAZO[1,2-b]PYRAZOLE DERIVATIVES AS ROS1 INHIBITORS |
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| CN106132967A CN106132967A (zh) | 2016-11-16 |
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| CN106580982B (zh) * | 2016-11-26 | 2017-09-22 | 王玉美 | 一种治疗药物流产后子宫出血的药物 |
| CN106866536A (zh) * | 2017-04-12 | 2017-06-20 | 中国农业大学 | 一种制备4‑卤代‑5‑氨基吡唑的方法 |
| WO2019033330A1 (en) * | 2017-08-17 | 2019-02-21 | Xw Laboratories, Inc. | PREPARATION AND USES OF DERIVATIVES TRACERS OF OXYGEN REACTIVE SPECIES |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| CN111087398A (zh) * | 2019-12-24 | 2020-05-01 | 上海万巷制药有限公司 | 一种制备拉罗替尼中间体的清洁工艺 |
| US20230067461A1 (en) | 2020-01-13 | 2023-03-02 | Aptabio Therapeutics Inc. | Novel pyrazole derivative |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN113416140B (zh) * | 2021-06-03 | 2023-01-13 | 万华化学集团股份有限公司 | 一种制备2-甲基戊二胺的方法 |
| US20250145628A1 (en) * | 2022-02-15 | 2025-05-08 | Novo Nordisk A/S | Pyrazolopyrimidines, compositions comprising them and uses thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075965A (zh) * | 1992-03-02 | 1993-09-08 | 藤泽药品工业株式会社 | 新的杂环衍生物 |
| CN1747949A (zh) * | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| CN102056927A (zh) * | 2008-05-13 | 2011-05-11 | Irm责任有限公司 | 作为激酶抑制剂的稠合含氮杂环及其组合物 |
| CN102083835A (zh) * | 2008-02-29 | 2011-06-01 | 惠氏有限责任公司 | 吡唑并[1，5-a]嘧啶的桥联双环杂环或螺双环杂环衍生物、其制备方法和用途 |
| WO2011153553A2 (en) * | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
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| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
| KR20040097375A (ko) | 2002-04-23 | 2004-11-17 | 시오노기 앤드 컴파니, 리미티드 | 피라졸로[1, 5-에이]피리미딘 유도체 및 이를 함유한엔에이디(피)에이취 산화효소 저해제 |
| CA2494700C (en) | 2002-08-26 | 2011-06-28 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
| UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
| AU2008345687A1 (en) | 2007-12-21 | 2009-07-09 | Wyeth Llc | Pyrazolo [1,5-a] pyrimidine compounds |
| CA2763631A1 (en) * | 2009-05-27 | 2010-12-02 | Abbott Laboratories | Pyrimidine inhibitors of kinase activity |
| JO3407B1 (ar) * | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| TWI585088B (zh) * | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物 |
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| CN1075965A (zh) * | 1992-03-02 | 1993-09-08 | 藤泽药品工业株式会社 | 新的杂环衍生物 |
| CN1747949A (zh) * | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| CN102083835A (zh) * | 2008-02-29 | 2011-06-01 | 惠氏有限责任公司 | 吡唑并[1，5-a]嘧啶的桥联双环杂环或螺双环杂环衍生物、其制备方法和用途 |
| CN102056927A (zh) * | 2008-05-13 | 2011-05-11 | Irm责任有限公司 | 作为激酶抑制剂的稠合含氮杂环及其组合物 |
| WO2011153553A2 (en) * | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
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|---|---|
| AU2015238298A1 (en) | 2016-09-15 |
| BR112016021507B1 (pt) | 2022-10-18 |
| AU2015238298B2 (en) | 2019-04-18 |
| US10342795B2 (en) | 2019-07-09 |
| BR112016021507A2 (enExample) | 2017-08-15 |
| CN106132967A (zh) | 2016-11-16 |
| KR102455518B1 (ko) | 2022-10-14 |
| CA2941206C (en) | 2022-09-20 |
| MX367913B (es) | 2019-09-11 |
| MX2016012669A (es) | 2016-12-14 |
| US20170173014A1 (en) | 2017-06-22 |
| EP3126366B1 (en) | 2018-06-06 |
| JP2017508777A (ja) | 2017-03-30 |
| EP3126366A1 (en) | 2017-02-08 |
| EA031639B1 (ru) | 2019-01-31 |
| ES2686747T3 (es) | 2018-10-19 |
| WO2015144801A1 (en) | 2015-10-01 |
| KR20160137566A (ko) | 2016-11-30 |
| CA2941206A1 (en) | 2015-10-01 |
| JP6527167B2 (ja) | 2019-06-05 |
| IL247948B (en) | 2019-03-31 |
| EA201691934A1 (ru) | 2017-01-30 |
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