CN106107966A - Improving eyesight ferment and preparation method thereof - Google Patents
Improving eyesight ferment and preparation method thereof Download PDFInfo
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- CN106107966A CN106107966A CN201610454977.XA CN201610454977A CN106107966A CN 106107966 A CN106107966 A CN 106107966A CN 201610454977 A CN201610454977 A CN 201610454977A CN 106107966 A CN106107966 A CN 106107966A
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- 238000000855 fermentation Methods 0.000 title claims abstract description 37
- 230000004438 eyesight Effects 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000004151 fermentation Effects 0.000 claims abstract description 33
- 210000000582 semen Anatomy 0.000 claims abstract description 29
- 241000251468 Actinopterygii Species 0.000 claims abstract description 24
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 22
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims abstract description 22
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- 238000001914 filtration Methods 0.000 claims abstract description 5
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- 239000000047 product Substances 0.000 claims description 12
- 229930006000 Sucrose Natural products 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
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- 229960004998 acesulfame potassium Drugs 0.000 claims description 7
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
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- Epidemiology (AREA)
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Abstract
The present invention proposes improving eyesight ferment and preparation method thereof, makes including following raw material: Semen Cassiae 35～50wt%, marine fish collagen Gly-His-Lys 4～6wt%, Fructus Lycii 10～20wt%, Poria 10～15wt%, phylloxanthin 5～10wt%, Fructus Crataegi 5～10wt% and additive 2～6wt%.Preparation method is: pulverized by Semen Cassiae, then carries out enzymolysis processing with pectase, obtains Semen Cassiae enzymolysis solution；Then, by marine fish collagen Gly-His-Lys, Poria, phylloxanthin, Fructus Crataegi and step 2) the Semen Cassiae enzymolysis solution that obtains first carries out lactate fermentation, it is subsequently adding Fructus Lycii and carries out culture propagation, the fermentation liquid homogenizing that will obtain, concentrate, centrifugal, filter, in filtrate, add additive, then carry out filtering, sterilizing.This ferment can effective releasing Chinese medicine active component, enhancing immunity simultaneously facilitates the recovery of eye eyesight.
Description
Technical field
The invention belongs to ferment technical field, be specifically related to a kind of improving eyesight ferment and preparation method thereof.
Background technology
Ferment is a kind of to be had special bioactive material, the namely " metabolism of yeast secretary by what aminoacid formed
Product ", also referred to as " enzyme ", it is a kind of biocatalyzer, is made up of protein.It is present in the animal and plant body of all work, is
Maintain body normal function, digest food, the required material of the one of the vital movements such as repair tissue.The eighties in 20th century, people
Utilize modern biotechnology to extract the ferment to skin beneficiating to add in cosmetics, to strengthen the function of skin, improve skin
Situation.One of principle of ferment beautifying skin is, by the aged cells digest and decompose in skin, to accelerate it and came off normally
Journey, cleaning skin, remove oils and fats, eliminate comedo, desalinate wrinkle, thoroughly improve skin condition so that it is consolidation, careful, have light
Pool.
Eye, also known as eyes, mesh, trick, is that major part animal receives light and forms the organ of image at brain.For people
For class, it is visual organ, one of most important sensory organ.Eye is a organ the finest, can be different
Under environment, the concrete form to oneself is changed so that the mankind obtain correct information in complex environment.Vision good
Badly judged by the size of retina resolution imagery ability, but when the refracting media (such as cornea, crystal, vitreous body etc.) of eye becomes
Muddy or when there is ametropia (including myopia, hypermetropia, astigmatism etc.), even if the good eye vision of retinal function still can under
Fall.At present, also there is no the report in terms of improving eyesight ferment.
Summary of the invention
For solving the problem that above-mentioned prior art exists, the present invention proposes a kind of improving eyesight ferment, and this ferment can effectively be released
Putting active ingredient of Chinese herbs, enhancing immunity simultaneously facilitates the recovery of eye eyesight.
The technical scheme is that and be achieved in that:
A kind of improving eyesight ferment, calculates according to percetage by weight, makes including following raw material: Semen Cassiae 35～50%, ocean
Fish skin collagen Gly-His-Lys 4～6%, Fructus Lycii 10～20%, Poria 10～15%, phylloxanthin 5～10%, Fructus Crataegi 5～10% with add
Add agent 2～6%.
Further, described additive includes sucrose, oligomeric galactose and acesulfame potassium.
Further, described marine fish collagen Gly-His-Lys is the marine fish collagen Gly-His-Lys that mean molecule quantity is less than 1000.
The marine fish collagen Gly-His-Lys of the present invention is known product, and its domestic commercially available prod is referred to as the oligomeric Gly-His-Lys of marine fish,
The oligomeric Gly-His-Lys of this marine fish has national standard, GB/T 22729-2008 " the oligomeric Gly-His-Lys of marine fish ".
It is a further object to provide the preparation method of a kind of improving eyesight ferment, comprise the following steps:
1) calculate according to percetage by weight, weigh Semen Cassiae 35～50%, marine fish collagen Gly-His-Lys 4～6%, Fructus Lycii
10～20%, Poria 10～15%, phylloxanthin 5～10%, Fructus Crataegi 5～10% standby with additive 2～6%；
2) Semen Cassiae is pulverized, then carry out enzymolysis processing with pectase, obtain Semen Cassiae enzymolysis solution；
3) by marine fish collagen Gly-His-Lys, Poria, phylloxanthin, Fructus Crataegi and step 2) mixing of the Semen Cassiae enzymolysis solution that obtains
After carry out high temperature sterilize and be cooled to room temperature, then add lactic acid starter strain, at a temperature of 30～35 DEG C lucifuge stand
Fermentation, until the pH value of this product reaches 3.9～4.5 termination fermentations；
4) to step 3) fermentation liquid that obtains adds Fructus Lycii, high temperature sterilize also cools down, then adds 0.1 in fermentation liquid
～the dry yeast of 0.16w/v%, ferment at a temperature of 25～30 DEG C, until the pH value of this product reaches 4.1～4.2 terminations and sends out
Ferment；
5) by step 4) the fermentation liquid homogenizing that obtains, concentrate, centrifugal, filter, filtrate is added additive, then carried out
Filter, sterilizing.
Further, described step 2) hydrolysis temperature is 40～50 DEG C, enzyme dosage is 2000～3000U/g.
Further, described step 5) processing condition is: fermentation liquid is homogenizing 10～5min under 40MPa.
Further, described step 5) concentration condition is: temperature 60～80 DEG C, is concentrated into 15～20Brix.
Beneficial effects of the present invention:
1, marine fish collagen peptide is because of digestibility height, therefore is mainly used in food nutrient fortifying, aminoacid supplement balance
Agent.Owing to marine fish collagen peptide contains abundant nutritional labeling, and there is exclusive humectant properties, make skin be full of profit, light
Clean, high resilience.Can stop outward the sunlight injury to skin, interior prevent the free radical destruction to skin.With marine fish hide glue
Former peptide is as one of supplementary nitrogen source in improving eyesight ferment sweat, it is possible to promote well lactic acid bacteria and saccharomycetic growth and
Metabolic process.
2, Semen Cassiae, Chinese medicine name.Leguminous plant Semen Cassiae or the dry mature seed of little Semen Cassiae, with its have improving eyesight merit and
Name.For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, poor vision, constipation.
3, the present invention accepts clinic case more than 100 people for medical treatment, and total effective rate reaches 76%, and the present invention has low cost, prevents and controls
The effects such as treatment vision weakens, heat clearing away nourishing the liver, mind tranquilizing and the heart calming.Wherein Fructus Lycii contain abundant carotene, multivitamin and
The required nutrient substance of the healthy eye such as calcium, ferrum, has the effect of significant improving eyesight.
Detailed description of the invention
Embodiment 1
A kind of improving eyesight ferment, makes including following raw material: Semen Cassiae 40g, marine fish collagen Gly-His-Lys 4g, Fructus Lycii 16g,
Poria 15g, phylloxanthin 10g, Fructus Crataegi 10g and additive 5g, described additive is 2g sucrose, 2g oligomeric galactose and 1g peace match
Honey.
The preparation method of a kind of improving eyesight ferment, comprises the following steps:
1) being pulverized by 40g Semen Cassiae, then carry out enzymolysis processing with pectase, hydrolysis temperature is 40 DEG C, enzyme dosage
It is 2000U/g, obtains Semen Cassiae enzymolysis solution.
2) by 4g marine fish collagen Gly-His-Lys, 15g Poria, 10g phylloxanthin, 10g Fructus Crataegi and step 2) Semen Cassiae that obtains
Carry out high temperature sterilize and be cooled to room temperature after the mixing of sub-enzymolysis solution, then add lactic acid starter strain, at a temperature of 30 DEG C
Lucifuge standing for fermentation, until the pH value of this product reaches 3.9 termination fermentations；
3) to step 2) fermentation liquid that obtains adds 16g Fructus Lycii, high temperature sterilize also cools down, then adds in fermentation liquid
The dry yeast of 0.1w/v%, ferments at a temperature of 30 DEG C, until the pH value of this product reaches 4.2 termination fermentations；
4) by step 5) fermentation liquid homogenizing 10min under 40MPa of obtaining；Temperature 60 C, is concentrated into 15Brix；It is centrifugal,
Filter, filtrate add 2g sucrose, 2g oligomeric galactose and 1g acesulfame potassium, then carry out filtering, sterilizing.
Embodiment 2
A kind of improving eyesight ferment, calculates according to percetage by weight, makes including following raw material: Semen Cassiae 45g, marine fish hide glue
Former Gly-His-Lys 6g, Fructus Lycii 20g, Poria 10g, phylloxanthin 8g, Fructus Crataegi 9g and additive 2g, described additive be 0.5g sucrose,
0.5g oligomeric galactose and 1g acesulfame potassium.
The preparation method of a kind of improving eyesight ferment, comprises the following steps:
1) being pulverized by 45g Semen Cassiae, then carry out enzymolysis processing with pectase, hydrolysis temperature is 50 DEG C, enzyme dosage
It is 2400U/g, obtains Semen Cassiae enzymolysis solution.
2) by 6g marine fish collagen Gly-His-Lys, 10g Poria, 8g phylloxanthin, 9g Fructus Crataegi and step 2) Semen Cassiae that obtains
Carry out high temperature sterilize and be cooled to room temperature after enzymolysis solution mixing, then add lactic acid starter strain, keep away at a temperature of 32 DEG C
Light standing for fermentation, until the pH value of this product reaches 4.2 termination fermentations；
3) to step 2) fermentation liquid that obtains adds 20g Fructus Lycii, high temperature sterilize also cools down, then adds in fermentation liquid
The dry yeast of 0.1w/v%, ferments at a temperature of 27 DEG C, until the pH value of this product reaches 4.1 termination fermentations；
4) by step 5) fermentation liquid homogenizing 10min under 40MPa of obtaining；Temperature 70 C, is concentrated into 17Brix；It is centrifugal,
Filter, filtrate add 0.5g sucrose, 0.5g oligomeric galactose and 1g acesulfame potassium, then carry out filtering, sterilizing.
Embodiment 3
A kind of improving eyesight ferment, calculates according to percetage by weight, makes including following raw material: Semen Cassiae 35g, marine fish hide glue
Former Gly-His-Lys 6g, Fructus Lycii 20g, Poria 15g, phylloxanthin 10g, Fructus Crataegi 10g and additive 4g, described additive is 1g sucrose, 2g
Oligomeric galactose and 1g acesulfame potassium.
The preparation method of a kind of improving eyesight ferment, comprises the following steps:
1) being pulverized by 35g Semen Cassiae, then carry out enzymolysis processing with pectase, hydrolysis temperature is 45 DEG C, enzyme dosage
It is 3000U/g, obtains Semen Cassiae enzymolysis solution.
2) by 6g marine fish collagen Gly-His-Lys, 15g Poria, 10g phylloxanthin, 10g Fructus Crataegi and step 2) Semen Cassiae that obtains
Carry out high temperature sterilize and be cooled to room temperature after the mixing of sub-enzymolysis solution, then add lactic acid starter strain, at a temperature of 35 DEG C
Lucifuge standing for fermentation, until the pH value of this product reaches 4.5 termination fermentations；
3) to step 2) fermentation liquid that obtains adds 20g Fructus Lycii, high temperature sterilize also cools down, then adds in fermentation liquid
The dry yeast of 0.1w/v%, ferments at a temperature of 27 DEG C, until the pH value of this product reaches 4.1 termination fermentations；
4) by step 5) fermentation liquid homogenizing 5min under 40MPa of obtaining；Temperature 80 DEG C, is concentrated into 20Brix；Centrifugal, mistake
Filter, adds 1g sucrose, 2g oligomeric galactose and 1g acesulfame potassium in filtrate, then carry out filtering, sterilizing.
Embodiment 4
Clinical trial part:
Data: selecting to be diagnosed as pseudomyopia teenager, the age is between 13～18 years old, case is randomly divided into 3 groups, often
Organize 30 examples, 3 groups of Genders, age, course of disease no significant differences (P ＞ 0.05).One group uses the embodiment of the present invention 1 to provide bright
Mesh ferment, each takes 50 milliliters, and every day takes 2 times sooner or later；One group uses the improving eyesight ferment that the embodiment of the present invention 2 provides, every time
Take 100 milliliters, take 1 every day；3rd group uses the improving eyesight ferment that the embodiment of the present invention 3 provides, each takes 100 milliliters,
Take 1 every day.After 90 days observe curative effect, the total effective rate of embodiment 1, embodiment 2 and embodiment 3 be respectively 78%, 76% with
81%.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (7)
1. an improving eyesight ferment, it is characterised in that according to percetage by weight calculate, make including following raw material: Semen Cassiae 35～
50%, marine fish collagen Gly-His-Lys 4～6%, Fructus Lycii 10～20%, Poria 10～15%, phylloxanthin 5～10%, Fructus Crataegi 5～
10% with additive 2～6%.
Improving eyesight ferment the most according to claim 1, it is characterised in that described additive include sucrose, oligomeric galactose with
Acesulfame potassium.
Improving eyesight ferment the most according to claim 1, it is characterised in that described marine fish collagen Gly-His-Lys is mean molecule
The amount marine fish collagen Gly-His-Lys less than 1000.
4. the preparation method of an improving eyesight ferment, it is characterised in that comprise the following steps:
1) calculate according to percetage by weight, weigh Semen Cassiae 35～50%, marine fish collagen Gly-His-Lys 4～6%, Fructus Lycii 10～
20%, Poria 10～15%, phylloxanthin 5～10%, Fructus Crataegi 5～10% are standby with additive 2～6%；
2) Semen Cassiae is pulverized, then carry out enzymolysis processing with pectase, obtain Semen Cassiae enzymolysis solution；
3) by marine fish collagen Gly-His-Lys, Poria, phylloxanthin, Fructus Crataegi and step 2) mixing of the Semen Cassiae enzymolysis solution that obtains is laggard
Row high temperature sterilize is also cooled to room temperature, then interpolation lactic acid starter strain, lucifuge standing for fermentation at a temperature of 30～35 DEG C,
Until the pH value of this product reaches 3.9～4.5 termination fermentations；
4) to step 3) fermentation liquid that obtains adds Fructus Lycii, high temperature sterilize also cools down, then add in fermentation liquid 0.1～
The dry yeast of 0.16w/v%, ferments at a temperature of 25～30 DEG C, until the pH value of this product reaches 4.1～4.2 termination fermentations；
5) by step 4) the fermentation liquid homogenizing that obtains, concentrate, centrifugal, filter, filtrate adds additive, then carry out filtering,
Sterilizing.
The preparation method of improving eyesight ferment the most according to claim 4, it is characterised in that described step 2) hydrolysis temperature is 40
～50 DEG C, enzyme dosage is 2000～3000U/g.
The preparation method of improving eyesight ferment the most according to claim 4, it is characterised in that described step 5) processing condition is:
Fermentation liquid is homogenizing 10～5min under 40MPa.
The preparation method of improving eyesight ferment the most according to claim 4, it is characterised in that described step 5) concentration condition is:
Temperature 60～80 DEG C, be concentrated into 15～20Brix.
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| CN201610454977.XA CN106107966A (en) | 2016-06-20 | 2016-06-20 | Improving eyesight ferment and preparation method thereof |
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| CN201610454977.XA Pending CN106107966A (en) | 2016-06-20 | 2016-06-20 | Improving eyesight ferment and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106962925A (en) * | 2017-03-30 | 2017-07-21 | 程君 | Make the composition and its method of ferment |
| CN109430827A (en) * | 2018-10-16 | 2019-03-08 | 广州汉兰图生物科技有限公司 | The semen sojae atricolor peptide health-care food and production method of intestines are led in a kind of nourishing the stomach |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356899A (en) * | 2011-09-07 | 2012-02-22 | 中国食品发酵工业研究院 | Natural fruit and vegetable ferment beverage, and preparation method thereof |
| CN104000176A (en) * | 2014-04-28 | 2014-08-27 | 吉林华鑫菌业有限责任公司 | Preparation method for auricularia auricula ferment |
| CN104825762A (en) * | 2015-05-26 | 2015-08-12 | 合肥丰瑞隆生物科技有限公司 | Traditional Chinese medicine with function of eyesight improvement |
| CN105167072A (en) * | 2015-08-02 | 2015-12-23 | 周学义 | Production method of functional Chinese wolfberry fruit enzyme and product thereof |
-
2016
- 2016-06-20 CN CN201610454977.XA patent/CN106107966A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356899A (en) * | 2011-09-07 | 2012-02-22 | 中国食品发酵工业研究院 | Natural fruit and vegetable ferment beverage, and preparation method thereof |
| CN104000176A (en) * | 2014-04-28 | 2014-08-27 | 吉林华鑫菌业有限责任公司 | Preparation method for auricularia auricula ferment |
| CN104825762A (en) * | 2015-05-26 | 2015-08-12 | 合肥丰瑞隆生物科技有限公司 | Traditional Chinese medicine with function of eyesight improvement |
| CN105167072A (en) * | 2015-08-02 | 2015-12-23 | 周学义 | Production method of functional Chinese wolfberry fruit enzyme and product thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张晔: "《排毒降火怎么吃》", 31 January 2013, 青岛出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106962925A (en) * | 2017-03-30 | 2017-07-21 | 程君 | Make the composition and its method of ferment |
| CN109430827A (en) * | 2018-10-16 | 2019-03-08 | 广州汉兰图生物科技有限公司 | The semen sojae atricolor peptide health-care food and production method of intestines are led in a kind of nourishing the stomach |
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