CN106104571B - 用于分析胚胎发育的方法和设备 - Google Patents

用于分析胚胎发育的方法和设备 Download PDF

Info

Publication number
CN106104571B
CN106104571B CN201580014122.9A CN201580014122A CN106104571B CN 106104571 B CN106104571 B CN 106104571B CN 201580014122 A CN201580014122 A CN 201580014122A CN 106104571 B CN106104571 B CN 106104571B
Authority
CN
China
Prior art keywords
embryo
target parameter
image
images
user
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580014122.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN106104571A (zh
Inventor
安东尼·帕鲁普·凯尔林
于尔根·伯恩特森
尼尔斯·拉姆辛
索伦·伯斯戈德
蒂内·基斯特戈德·卡约杰
雷敦·伯格霍尔德·库尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unisense Fertilitech AS
Original Assignee
Unisense Fertilitech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unisense Fertilitech AS filed Critical Unisense Fertilitech AS
Publication of CN106104571A publication Critical patent/CN106104571A/zh
Application granted granted Critical
Publication of CN106104571B publication Critical patent/CN106104571B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/22—Matching criteria, e.g. proximity measures
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/00—2D [Two Dimensional] image generation
    • G06T11/60—Editing figures and text; Combining figures or text
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G06T7/0016—Biomedical image inspection using an image reference approach involving temporal comparison
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/20—Analysis of motion
    • G06T7/246—Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10016—Video; Image sequence
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30044—Fetus; Embryo

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Quality & Reliability (AREA)
  • Cell Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Multimedia (AREA)
  • Data Mining & Analysis (AREA)
  • Human Computer Interaction (AREA)
  • Evolutionary Computation (AREA)
  • Evolutionary Biology (AREA)
  • Artificial Intelligence (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580014122.9A 2014-03-14 2015-02-12 用于分析胚胎发育的方法和设备 Active CN106104571B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1404554.6A GB2524082A (en) 2014-03-14 2014-03-14 Methods and apparatus for analysing embryo development
GB1404554.6 2014-03-14
PCT/EP2015/052991 WO2015135718A1 (en) 2014-03-14 2015-02-12 Methods and apparatus for analysing embryo development

Publications (2)

Publication Number Publication Date
CN106104571A CN106104571A (zh) 2016-11-09
CN106104571B true CN106104571B (zh) 2019-07-30

Family

ID=50634761

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580014122.9A Active CN106104571B (zh) 2014-03-14 2015-02-12 用于分析胚胎发育的方法和设备

Country Status (8)

Country Link
US (1) US10282842B2 (enExample)
EP (1) EP3117367B1 (enExample)
JP (1) JP6425745B2 (enExample)
CN (1) CN106104571B (enExample)
AU (1) AU2015230291B2 (enExample)
ES (1) ES2701899T3 (enExample)
GB (1) GB2524082A (enExample)
WO (1) WO2015135718A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018014991A (ja) 2016-07-13 2018-02-01 ソニー株式会社 情報処理装置、情報処理方法及び情報処理システム
JP2018022216A (ja) 2016-08-01 2018-02-08 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
JP6946807B2 (ja) * 2017-07-19 2021-10-06 大日本印刷株式会社 画像表示装置、プログラム及び制御方法
CN111755121A (zh) * 2019-03-27 2020-10-09 北京菁医林国际医院管理有限公司 一种未成年人体格发育趋势的评估方法及装置
CN110363218B (zh) * 2019-06-06 2023-07-11 张孝东 一种胚胎无创评估方法及装置
CN110443282B (zh) * 2019-07-05 2022-02-15 华中科技大学 一种胚胎时序图像中的胚胎发育阶段分类方法
CN113528583A (zh) * 2021-07-15 2021-10-22 澳门大学 自动化显微注射方法、装置、系统、设备及存储介质
CN114067317B (zh) * 2021-11-24 2025-03-18 北京航空航天大学合肥创新研究院(北京航空航天大学合肥研究生院) 染色体异常事件的检测方法、装置、电子设备及介质

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101331500A (zh) * 2005-10-14 2008-12-24 尤尼森斯繁殖技术公司 细胞群的变化的测定
CN102576027A (zh) * 2009-08-22 2012-07-11 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
WO2013148611A1 (en) * 2012-03-27 2013-10-03 Sony Corporation Method and system of providing interactive information

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2689626C (en) * 2007-06-06 2016-10-25 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US8515143B2 (en) * 2009-01-09 2013-08-20 Dai Nippon Printing Co., Ltd. Embryo quality evaluation assistance system, embryo quality evaluation assistance apparatus and embryo quality evaluation assistance method
WO2012047678A2 (en) * 2010-09-27 2012-04-12 Auxogyn, Inc. Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes, and stem cells
ES2717478T3 (es) * 2012-05-31 2019-06-21 Ares Trading Sa Métodos de predicción de blastocistos embrionarios in vitro
EP2864475A1 (en) * 2012-06-25 2015-04-29 Unisense Fertilitech A/S Method and apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101331500A (zh) * 2005-10-14 2008-12-24 尤尼森斯繁殖技术公司 细胞群的变化的测定
US8265357B2 (en) * 2005-10-14 2012-09-11 Unisense Fertilitech A/S Determination of a change in a cell population
CN102576027A (zh) * 2009-08-22 2012-07-11 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
WO2013148611A1 (en) * 2012-03-27 2013-10-03 Sony Corporation Method and system of providing interactive information

Also Published As

Publication number Publication date
JP2017513514A (ja) 2017-06-01
GB2524082A (en) 2015-09-16
CN106104571A (zh) 2016-11-09
AU2015230291A1 (en) 2016-09-01
ES2701899T3 (es) 2019-02-26
EP3117367B1 (en) 2018-10-31
US10282842B2 (en) 2019-05-07
US20160379364A1 (en) 2016-12-29
WO2015135718A1 (en) 2015-09-17
GB201404554D0 (en) 2014-04-30
EP3117367A1 (en) 2017-01-18
JP6425745B2 (ja) 2018-11-21
AU2015230291B2 (en) 2019-11-21

Similar Documents

Publication Publication Date Title
CN106104571B (zh) 用于分析胚胎发育的方法和设备
EP3201313B1 (en) Embryo assessment
Liu et al. Time-lapse deselection model for human day 3 in vitro fertilization embryos: the combination of qualitative and quantitative measures of embryo growth
Adolfsson et al. Morphology vs morphokinetics: a retrospective comparison of inter-observer and intra-observer agreement between embryologists on blastocysts with known implantation outcome
JP7072067B2 (ja) 胚の生存率を推定するためのシステムおよび方法
JP5731748B2 (ja) 卵割球の分裂および運動に基づく胚品質の評価
Aguilar et al. The human first cell cycle: impact on implantation
JP7592602B2 (ja) 体外受精着床の成功の予測因子を識別するためのシステム及び方法
ES2831867T3 (es) Evaluación automática de embriones en incubación in vitro
EP2855664B1 (en) Embryo quality assessment based on blastocyst development
CN104411817A (zh) 方法和设备
Mensing et al. Using blastocyst re-expansion rate for deciding when to warm a new blastocyst for single vitrified–warmed blastocyst transfer
JP7282809B2 (ja) 細胞生成支援装置、方法、及びプログラム
Campbell Non-invasive techniques: embryo selection by time-lapse imaging
Kovacs et al. Choosing an embryo for transfer
JPWO2021074945A5 (enExample)
Cruz et al. Real-time imaging strategies to improve morphological assessment
CN119540225A (zh) 胚胎发育异常检测方法及电子设备
CN120624666A (zh) 一种奶牛良种基因快速筛选扩繁方法
Azita et al. Morphokinetic analysis of pre-implantation embryos in assisted reproduction program

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant