CN106103447B - 连接物关联激酶1的抑制剂、包含其的组合物、及其使用方法 - Google Patents

连接物关联激酶1的抑制剂、包含其的组合物、及其使用方法 Download PDF

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CN106103447B
CN106103447B CN201580014255.6A CN201580014255A CN106103447B CN 106103447 B CN106103447 B CN 106103447B CN 201580014255 A CN201580014255 A CN 201580014255A CN 106103447 B CN106103447 B CN 106103447B
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compound
aak1
disease
application
compounds
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CN106103447A (zh
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毕映枝
戈德温·库米
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Lexicon Pharmaceuticals Inc
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Lexicon Genetics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201580014255.6A 2014-03-17 2015-03-16 连接物关联激酶1的抑制剂、包含其的组合物、及其使用方法 Active CN106103447B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953976P 2014-03-17 2014-03-17
US61/953,976 2014-03-17
PCT/US2015/020696 WO2015142714A1 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use

Publications (2)

Publication Number Publication Date
CN106103447A CN106103447A (zh) 2016-11-09
CN106103447B true CN106103447B (zh) 2019-07-16

Family

ID=52727478

Family Applications (1)

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CN201580014255.6A Active CN106103447B (zh) 2014-03-17 2015-03-16 连接物关联激酶1的抑制剂、包含其的组合物、及其使用方法

Country Status (14)

Country Link
US (1) US9682982B2 (OSRAM)
EP (2) EP3719021B1 (OSRAM)
JP (1) JP6553081B2 (OSRAM)
CN (1) CN106103447B (OSRAM)
AR (1) AR099766A1 (OSRAM)
AU (1) AU2015231672B2 (OSRAM)
CA (1) CA2941870C (OSRAM)
DK (2) DK3719021T3 (OSRAM)
ES (2) ES2911388T3 (OSRAM)
HU (1) HUE050975T2 (OSRAM)
PL (2) PL3119783T3 (OSRAM)
PT (2) PT3119783T (OSRAM)
TW (1) TW201620911A (OSRAM)
WO (1) WO2015142714A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038786T2 (hu) * 2012-03-09 2018-11-28 Lexicon Pharmaceuticals Inc Pirazolo[1,5-a]pirimidin-alapú vegyületek, ezeket tartalmazó kompozíciók és eljárások alkalmazásukra
WO2015054358A1 (en) 2013-10-11 2015-04-16 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CN109369576B (zh) * 2018-09-19 2020-11-27 上海凌凯医药科技有限公司 一种合成3-甲基氧杂环丁烷-3-(4-硝基苯基)碳酸酯的方法
EP4138844A1 (en) 2020-04-21 2023-03-01 Lexicon Pharmaceuticals, Inc. 4-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine for use in the the treatment of cov-229e or cov-oc43 coronaviruses infections
WO2021216441A1 (en) 2020-04-21 2021-10-28 Lexicon Pharmaceuticals, Inc. Aak1 inhibitors for use in treating viral infections
WO2023196584A2 (en) * 2022-04-08 2023-10-12 New York University Endocytosis inhibitors and their use for pain treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1118468C (zh) * 1998-03-11 2003-08-20 弗·哈夫曼-拉罗切有限公司 吡唑并嘧啶和吡唑并三嗪
WO2011087999A1 (en) * 2010-01-14 2011-07-21 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines as mark inhibitors
WO2013134228A1 (en) * 2012-03-09 2013-09-12 Lexicon Pharmaceuticals, Inc. PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP2417138B1 (en) * 2009-04-09 2019-11-27 Merck Sharp & Dohme Corp. Pyrazolo[1, 5-a]pyrimidine derivatives as mtor inhibitors
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8969565B2 (en) * 2012-03-09 2015-03-03 Lexicon Pharmaceuticals, Inc. Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use
PL2822555T3 (pl) * 2012-03-09 2018-04-30 Lexicon Pharmaceuticals Inc Inhibicja związanej z adaptorem kinazy-1 dla leczenia bólu

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1118468C (zh) * 1998-03-11 2003-08-20 弗·哈夫曼-拉罗切有限公司 吡唑并嘧啶和吡唑并三嗪
WO2011087999A1 (en) * 2010-01-14 2011-07-21 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines as mark inhibitors
WO2013134228A1 (en) * 2012-03-09 2013-09-12 Lexicon Pharmaceuticals, Inc. PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Also Published As

Publication number Publication date
DK3119783T3 (da) 2020-09-28
AU2015231672A1 (en) 2016-09-15
PT3719021T (pt) 2022-04-08
US9682982B2 (en) 2017-06-20
WO2015142714A1 (en) 2015-09-24
PL3119783T3 (pl) 2021-01-11
ES2821441T3 (es) 2021-04-26
HUE050975T2 (hu) 2021-01-28
AU2015231672B2 (en) 2019-06-20
AR099766A1 (es) 2016-08-17
JP6553081B2 (ja) 2019-07-31
TW201620911A (zh) 2016-06-16
EP3719021B1 (en) 2022-03-09
US20160039824A1 (en) 2016-02-11
JP2017507980A (ja) 2017-03-23
EP3119783B1 (en) 2020-06-24
PL3719021T3 (pl) 2022-06-20
CA2941870A1 (en) 2015-09-24
ES2911388T3 (es) 2022-05-19
DK3719021T3 (da) 2022-06-13
HK1226065A1 (zh) 2017-09-22
CA2941870C (en) 2022-07-19
EP3119783A1 (en) 2017-01-25
EP3719021A1 (en) 2020-10-07
CN106103447A (zh) 2016-11-09
PT3119783T (pt) 2020-09-24

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