CN106074690A - A kind of vola skin care solution and preparation method thereof - Google Patents

A kind of vola skin care solution and preparation method thereof Download PDF

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Publication number
CN106074690A
CN106074690A CN201610405608.1A CN201610405608A CN106074690A CN 106074690 A CN106074690 A CN 106074690A CN 201610405608 A CN201610405608 A CN 201610405608A CN 106074690 A CN106074690 A CN 106074690A
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vola
skin care
care solution
allantoin
pca
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司红岩
王建桦
李珍
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Xuchang University
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Xuchang University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
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  • Medical Informatics (AREA)
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  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a kind of vola skin care solution and preparation method thereof, vola skin care solution is as follows by weight concrete configuration by following raw material: D pantothenylol 1 2%, pyrrolidone sodium carboxylate PCA Na1 2%, nicotiamide 1 2%, allantoin 0.2 0.3%, water solublity olive oil 4 6%, PEG 40 castor oil hydrogenated 0.1 0.5%, Peppermint essential oil 0.02 0.04%, Kazon 0.05%.The vola skin care solution that the present invention provides can make vola skin normal keratinization, promotes the healing of season cracking wound, makes vola skin moisturizing softness flexible；The conditioning liquid that the present invention provides is coated in foot, it is possible to absorbing rapidly and without glutinous soapy feeling, manufacturing process is simple, environment friendly and pollution-free, easy to use.

Description

A kind of vola skin care solution and preparation method thereof
Technical field
The invention belongs to technique in skin care field, especially relate to a kind of vola skin care solution and preparation method thereof.
Background technology
Human body is deficient in vitamin or other factors can cause vola xerosis cutis even to be chapped, and especially old people is in the winter During it dry weather even more serious.Uncomfortable physiology and the psychology to patient of foot all causes large effect.
Summary of the invention
In view of this, it is contemplated that propose a kind of vola skin care solution and preparation method thereof, it is dried solving foot Or the problem such as chap.
For reaching above-mentioned purpose, the technical scheme is that and be achieved in that:
A kind of vola skin care solution, as follows by weight concrete configuration by following raw material: D-panthenol 1-2%, pyrrolidine Keto carboxylic acid sodium PCA-Na 1-2%, nicotiamide 1-2%, allantoin 0.2-0.3%, water solublity olive oil 4-6%, PEG-40 hydrogenate Oleum Ricini 0.1-0.5%, Peppermint essential oil 0.02-0.04%, Kazon 0.05%, and excess water.
Preferably, vola skin care solution, as follows by weight concrete configuration by following raw material: D-panthenol 1.3-1.6%, Pyrrolidone sodium carboxylate PCA-Na 1.3-1.6%, nicotiamide 1.3-1.6%, allantoin 0.23-0.26%, water solublity olive oil 4.5-5.5%, Cremophor RH40 0.2-0.3%, Peppermint essential oil 0.03%, Kazon 0.05%, and excess water.
Preferably, D-panthenol, pyrrolidone sodium carboxylate PCA-Na, the mass ratio of nicotiamide are 1:1:1.
Preferably, D-panthenol, pyrrolidone sodium carboxylate PCA-Na, nicotiamide, the mass ratio of allantoin are 5-6:5-6:5- 6:1.
The present invention also provides for the preparation method of a kind of vola skin care solution, comprises the steps:
S1: be proportionally added into allantoin in the hot water of 85-95 DEG C, after stirring and dissolving, temperature is down to 45-50 DEG C, under stirring Dissolve in D-panthenol, pyrrolidone sodium carboxylate PCA-Na, nicotiamide and water solublity olive oil the most in proportion, cool down after mix homogeneously To less than 40 degree, obtain component A；
S2: appropriate Peppermint essential oil, castor oil hydrogenated and PEG400 are mixed and stirred for uniformly until transparent obtaining B Component；
S3: B component added in A, adds a certain amount of Kazon, dissolves and obtains transparent aqueous humour completely, obtains vola skin Conditioning liquid.
Preferably, in step S1, the solution temperature of allantoin is 90 DEG C.
Preferably, step S1 is cooled to room temperature after mix homogeneously.
Relative to prior art, vola of the present invention skin care solution and preparation method thereof has the advantage that
In the skin care solution of vola of the present invention, D-panthenol is the precursor of vitamin B5, can promote human body protein, Fat, the metabolism of saccharide, stimulate the growth of epithelial cell, promotes normal keratinization, promotes wound healing, plays antiinflammatory moisturizing and makees With；Pyrrolidone sodium carboxylate PCA-Na has high humectant properties, and skin moisturizing softness can be made flexible；Nicotiamide has another name called dimension Raw element B3, works in the metabolism of protein and sugar, can improve the nutrition of the mankind, skin can be prevented thick for skin care item Rough, safeguard that Skin Cell is healthy, promote skin-whitening.Water solublity olive oil has fabulous tax lipid and makes skin moisturizing soft Soft, there is auxiliary solubilization simultaneously；PEG400 as lubricant and wetting agent, with Cremophor RH40 share right Dissolve quintessence oil and have synergistic function；Allantoin has the effects such as softening keratin, antiallergic, promotion wound healing, promotes flesh The water absorbing capacity of skin outermost layer tissue, has lucifuge, antioxidation, makes that skin emolliency is flexible, gloss, prevents dry and cracked equivalence Really.The physiological functions such as allantoin has promotion cell growth, accelerates wound healing, horny layer softening albumen, have lucifuge, sterilize and prevent Corruption, pain relieving, antioxidation, can make skin keep moisture content, moisten and soft.D-panthenol can add with the complex role of allantoin The healing of fast season cracking wound；Pyrrolidone sodium carboxylate PCA-Na can further speed up season cracking with the addition of nicotiamide The healing of wound.
The conditioning liquid that the present invention provides, can make vola skin normal keratinization, promotes the healing of season cracking wound, makes foot End skin moisturizing softness is flexible；The present invention provides conditioning liquid to be coated in foot, absorbs rapidly and without glutinous soapy feeling, manufacturing process letter Single, environment friendly and pollution-free, easy to use.
Detailed description of the invention
Unless otherwise indicated, term used herein is respectively provided with the implication that those skilled in the art's routine understands, in order to Readily appreciate the present invention, terms more used herein have been carried out following definitions.
Using in the specification and in the claims, odd number type " " and " this " include plural reference, unless on The most separately have and clearly state.Such as, term " (one) cell " includes the cell of plural number, including its mixture.
All of Digital ID, such as pH, temperature, time, concentration, including scope, be all approximation.It is to be understood that, although Term " about " is all added before all of Digital ID of the clearest and the most definite narration.Simultaneously it will also be understood that, although the clearest and the most definite Narration, reagent described herein is only example, and its equivalent is known in the art.
The D-panthenol of the present invention, pyrrolidone sodium carboxylate PCA-Na, nicotiamide, allantoin, water solublity olive oil, PEG-40 Castor oil hydrogenated, Peppermint essential oil, Kazon all can be prepared by routine techniques well known by persons skilled in the art or directly buy Obtain.
The present invention is described in detail below in conjunction with embodiment.
Embodiment 1
A kind of vola skin care solution that the present embodiment 1 provides, as follows by weight concrete configuration by following raw material: D-is general Alcohol 1%, pyrrolidone sodium carboxylate PCA-Na 1%, nicotiamide 1%, allantoin 0.2%, water solublity olive oil 4%, PEG-40 hydrogen Change Oleum Ricini 0.1%, Peppermint essential oil 0.02%, Kazon 0.05%, excess water.
The preparation method of a kind of vola skin care solution is as follows: adds allantoin in 85 DEG C of hot water according to the above ratio, stirs After mixing dissolving, temperature is down to 45-50 DEG C, dissolves in D-panthenol, pyrrolidone sodium carboxylate PCA-Na, nicotinoyl under stirring the most in proportion Amine and water solublity olive oil, be cooled to less than 40 degree, obtain component A after mix homogeneously；By appropriate Peppermint essential oil, castor oil hydrogenated And PEG400 is mixed and stirred for uniformly until transparent obtaining B component；B component is added in A, add a certain amount of Kazon, molten Solution obtains transparent aqueous humour completely, obtains vola skin care solution.
Embodiment 2
A kind of vola skin care solution that the present embodiment provides, as follows by weight concrete configuration by following raw material: D-is general Alcohol 1.5%, pyrrolidone sodium carboxylate PCA-Na 1.5%, nicotiamide 1.5%, allantoin 0.25%, water solublity olive oil 5%, Cremophor RH40 0.3%, Peppermint essential oil 0.03%, Kazon 0.05%, excess water.
The preparation method of a kind of vola skin care solution is as follows: adds allantoin in 90 DEG C of hot water according to the above ratio, stirs After mixing dissolving, temperature is down to 45-50 DEG C, dissolves in D-panthenol, pyrrolidone sodium carboxylate PCA-Na, nicotinoyl under stirring the most in proportion Amine and water solublity olive oil, be cooled to less than 40 degree, obtain component A after mix homogeneously；By appropriate Peppermint essential oil, castor oil hydrogenated And PEG400 is mixed and stirred for uniformly until transparent obtaining B component；B component is added in A, add a certain amount of Kazon, molten Solution obtains transparent aqueous humour completely, obtains vola skin care solution.
Embodiment 3
A kind of vola skin care solution that the present embodiment provides, as follows by weight concrete configuration by following raw material: D-is general Alcohol 2%, pyrrolidone sodium carboxylate PCA-Na 2%, nicotiamide 2%, allantoin 0.3%, water solublity olive oil 6%, PEG-40 hydrogen Change Oleum Ricini 0.5%, Peppermint essential oil 0.04%, Kazon 0.05%.
The preparation method of a kind of vola skin care solution is as follows: adds allantoin in 95 DEG C of hot water according to the above ratio, stirs After mixing dissolving, temperature is down to 45-50 DEG C, dissolves in D-panthenol, pyrrolidone sodium carboxylate PCA-Na, nicotinoyl under stirring the most in proportion Amine and water solublity olive oil, be cooled to less than 40 degree, obtain component A after mix homogeneously；By appropriate Peppermint essential oil, castor oil hydrogenated And PEG400 is mixed and stirred for uniformly until transparent obtaining B component；B component is added in A, add a certain amount of Kazon, molten Solution obtains transparent aqueous humour completely, obtains vola skin care solution.
Comparative example 1:
Compared with Example 2, without allantoin in the skin care solution of vola.
Comparative example 2:
Compared with Example 2, without D-panthenol in the skin care solution of vola.
Comparative example 3:
Compared with Example 2, without pyrrolidone sodium carboxylate PCA-Na and nicotiamide in the skin care solution of vola.
The vola skin care solution using embodiment of the present invention 1-3 and comparative example 1-3 to provide is coated uniformly on dry respectively The foot chapped, embodiment 1-3 use after without glutinous soapy feeling, be dried after using half an hour situation of chapping be improved significantly, use After twice；And comparative example 1-3 is dried, after using half an hour, situation of chapping and still exists, after using 2 hours, it is dried situation of chapping Being improved, the complex role of D-panthenol and allantoin can accelerate the healing of season cracking wound, pyrrolidone sodium carboxylate The addition of PCA-Na and nicotiamide can further speed up the healing of season cracking wound.
Although above it has been shown and described that embodiments of the invention, it is to be understood that above-described embodiment is example Property, it is impossible to being interpreted as limitation of the present invention, those of ordinary skill in the art within the scope of the invention can be to above-mentioned Embodiment is changed, revises, replaces and modification.

Claims (7)

1. a vola skin care solution, it is characterised in that: as follows by weight concrete configuration by following raw material: D-panthenol 1- 2%, pyrrolidone sodium carboxylate PCA-Na 1-2%, nicotiamide 1-2%, allantoin 0.2-0.3%, water solublity olive oil 4-6%, Cremophor RH40 0.1-0.5%, Peppermint essential oil 0.02-0.04%, Kazon 0.05%, and excess water.
Vola the most according to claim 1 skin care solution, it is characterised in that: by following raw material by weight concrete configuration As follows: D-panthenol 1.3-1.6%, pyrrolidone sodium carboxylate PCA-Na1.3-1.6%, nicotiamide 1.3-1.6%, allantoin 0.23-0.26%, water solublity olive oil 4.5-5.5%, Cremophor RH40 0.2-0.3%, Peppermint essential oil 0.03%, card Pine 0.05%, and excess water.
Vola the most according to claim 1 skin care solution, it is characterised in that: D-panthenol, pyrrolidone sodium carboxylate PCA- Na, the mass ratio of nicotiamide are 1:1:1.
Vola the most according to claim 1 skin care solution, it is characterised in that: D-panthenol, pyrrolidone sodium carboxylate PCA- Na, nicotiamide, the mass ratio of allantoin are 5-6:5-6:5-6:1.
5. the preparation method of the vola skin care solution described in any one of claim 1-4, it is characterised in that: include walking as follows Rapid:
S1: be proportionally added into allantoin in the hot water of 85-95 DEG C, after stirring and dissolving, temperature is down to 45-50 DEG C, under stirring successively Dissolve in D-panthenol, pyrrolidone sodium carboxylate PCA-Na, nicotiamide and water solublity olive oil in proportion, after mix homogeneously, be cooled to 40 Below degree, obtain component A；
S2: appropriate Peppermint essential oil, castor oil hydrogenated and PEG400 are mixed and stirred for uniformly until transparent obtaining B component；
S3: B component added in A, adds a certain amount of Kazon, dissolves and obtains transparent aqueous humour completely, obtains vola skin nursing Liquid.
6. the preparation method of the vola skin care solution described in claim 5, it is characterised in that: the dissolving of allantoin in step S1 Temperature is 90 DEG C.
7. the preparation method of the vola skin care solution described in claim 5, it is characterised in that: cold after mix homogeneously in step S1 But to room temperature.
CN201610405608.1A 2016-06-08 2016-06-08 A kind of vola skin care solution and preparation method thereof Pending CN106074690A (en)

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Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101394833A (en) * 2006-03-06 2009-03-25 宝洁公司 Lipophilic personal care composition
CN101687106A (en) * 2007-06-01 2010-03-31 盖尔德马研究及发展公司 New moisturizer and use thereof
CN105168478A (en) * 2015-08-28 2015-12-23 无限极（中国）有限公司 Skin care product and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101394833A (en) * 2006-03-06 2009-03-25 宝洁公司 Lipophilic personal care composition
CN101687106A (en) * 2007-06-01 2010-03-31 盖尔德马研究及发展公司 New moisturizer and use thereof
CN105168478A (en) * 2015-08-28 2015-12-23 无限极（中国）有限公司 Skin care product and preparation method thereof

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