CN106074611A - A kind of snake venom compound external-use agent of anti-acne and preparation method thereof - Google Patents
A kind of snake venom compound external-use agent of anti-acne and preparation method thereof Download PDFInfo
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- CN106074611A CN106074611A CN201610542079.XA CN201610542079A CN106074611A CN 106074611 A CN106074611 A CN 106074611A CN 201610542079 A CN201610542079 A CN 201610542079A CN 106074611 A CN106074611 A CN 106074611A
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- snake venom
- baicalin
- acne
- elapidae
- venom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
Snake venom compound external-use agent that the invention discloses a kind of anti-acne and preparation method thereof.This snake venom compound external-use agent contains the crude drug of 1 8%, and described crude drug is mixed to get by 50 70% Elapidae snake venom dry powder and 30 50% baicalin goods, and described percentage ratio is by mass percentage；Every 100g Elapidae snake venom refines dry powder and should comprise neurotoxin 6 12g, cardiotoxin 10 45g, cobra-venom factor 1.5 3g, Recombinant Naja naja atra NGF 0.2 0.5g；In every 100g baicalin goods, the content of baicalin is more than 98g.The neurotoxin of cobra venom, cytotoxin and nerve growth factor have antibacterial, antiinflammatory, antiallergic and alleviate the effect of skin lesion, the collaborative antioxidation of baicalin, antiinflammatory and the effect of minimizing fat secretion, skin irritation and the drug resistance of anti-acne medicine can be reduced, provide more preferably biological preparation for clinical acne treatment.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly to snake venom compound external-use agent and the preparation side thereof of a kind of anti-acne
Method.
Background technology
The common skin diseases that acne is hair follicle and sebaceous gland chronic inflammatory disease causes, takes place mostly in face, forms acne, mound
The skin lesion such as rash and pustule.Some acne can cause pigmentation and permanent cicatrix, all produces patient's appearance and psychology
Harmful effect.Epidemiological study display teenager has 90% acne that the different order of severity occurred, wherein adolescence man
The incidence rate of child and girl is respectively 95% and 83%, 25-34 year Adult Groups in incidence rate also up to 80%.
Topical administration is the preferred option of clinical treatment mild acne, in being also, the basic medication of severe acne.Face at present
The external used medicine of bed treatment acne has tretinoin, benzoyl peroxide, antibiotics, Azelaic Acid and dapsone etc.；Common external
Pharmaceutical dosage form has cream, ointment, gel, emulsion, tincture, liniment and lotion etc..All there is clinic in these anti-acne medicines
Curative effect is not ideal enough, and has skin irritation and the untoward reaction of drug resistance such as xerosis cutis, desquamation, erythema, pruritus；Medicine system
Agent there is also the problem that transdermal characteristic, absorbability, stability and targeting are the highest.
China is used as medicine with Serpentis and treats the with a long history of dermatosis, and Li Shizhen (1518-1593 A.D.) points out that in Compendium of Material Medica " Serpentis cures mainly and hides
Skin ulcer, skin insensitive impediment etc. weighs disease ".Modern Chinese medicine thinks that Serpentis is invigorated blood circulation the effects such as the beautiful skin of normal pulse.Chinese Medical Sciences University is from Agkistrodon halys
The reptilase emulsifiable paste developed in poison has significant curative effect to chronic eczema and acne.Research display cobra venom has good resisting
Scorching, antibacterial and anti-allergic effects, it is possible to alleviate the skin lesion of animal.
Radix Scutellariae has pharmacological action widely, and ancient books is i.e. recorded and used scutellaria for treating acne.Research display Radix Scutellariae have antioxidation,
Antiinflammatory and the effect of suppression propionibacterium acnes, still can horny layer softening, alleviate follicular keratosis, reduce pigmentation.Additionally, Radix Scutellariae
There is phytoestrogenic activity, sebum secretion can be suppressed with antagonism androgen.
Summary of the invention
The primary and foremost purpose of the present invention is that the shortcoming overcoming prior art is with not enough, it is provided that the snake venom compound recipe of a kind of anti-acne
External preparation.
Another object of the present invention is to provide the preparation method of the snake venom compound external-use agent of described anti-acne.
The purpose of the present invention is achieved through the following technical solutions: the snake venom compound external-use agent of a kind of anti-acne, containing 1-8%
Crude drug, described crude drug is mixed to get by 50-70% Elapidae snake venom dry powder and 30-50% baicalin goods, institute
The percentage ratio stated is by mass percentage；Every 100g Elapidae snake venom refines dry powder and should comprise neurotoxin 6-12g, heart
Toxin 10-45g, cobra-venom factor 1.5-3g, Recombinant Naja naja atra NGF 0.2-0.5g；In every 100g baicalin goods
The content of baicalin is more than 98g.
Described Elapidae snake venom is preferably naja naja atra venom, Ophiophagus hannah (Cantor)., Bungarus toxin or bungarotoxin.
The preparation method of described Elapidae snake venom, comprises the steps: molten for Elapidae snake venom with deionized water
Solve, centrifugal, take supernatant and carry out isolated and purified, remove the component caused bleeding in snake venom, remaining composition carries out lyophilization,
Refined dry powder to Elapidae snake venom.
Described isolation and purification method is gel filtration, and Sephadex-G-75 gel column selected by gel filtration, and post is high
100cm, internal diameter 1.6cm, eluent is the Spirit of Mindererus. of 0.05mol/L.
Described baicalin goods are adopted and are prepared with the following method: baicalin extracts preparation from Radix Scutellariae Chinese crude drug, pulverize Huang
Use enzyme solution tentatively to extract after a kind of reed mentioned in ancient books medical material, then after alcohol reflux concentrate drying, obtain baicalin goods.
The snake venom compound external-use agent of described anti-acne can be compound gel, ointment, Liposomal agents or nanometer fat
Plastid agent.
The preparation method of the snake venom compound external-use agent of described anti-acne, comprises the steps: 50-70% Elapidae
Snake venom dry powder and 30-50% baicalin goods mix homogeneously, obtain crude drug；Take the crude drug of 1-8%, add adjuvant and/or
Carrier, mix homogeneously, obtain the snake venom compound external-use agent of anti-acne；Every 100g Elapidae snake venom refines dry powder and should comprise nerve
Toxin 6-12g, cardiotoxin 10-45g, cobra-venom factor 1.5-3g, Recombinant Naja naja atra NGF 0.2-0.5g；Often
In 100g baicalin goods, the content of baicalin is more than 98g.Described percentage ratio is mass percent.
The present invention has such advantages as relative to prior art and effect:
Neurotoxin, cytotoxin and the nerve growth factor that cobra venom contains has antibacterial, antiinflammatory, antiallergic and subtracts
The effect of light skin lesion, the collaborative antioxidation of baicalin, antiinflammatory, suppression propionibacterium acnes and the effect of minimizing fat secretion,
Make up the defect that current anti-acne chemicals curative effect is notable not and untoward reaction is more, reduce the skin thorn of anti-acne medicine
Swash property and drug resistance, provide more preferably biological preparation for clinical acne treatment.
The snake venom of the present invention and baicalin can play antiinflammatory, antioxidation, suppression Cuo for all links of pathogenesis of acne
Skin ulcer bacillus grows, reduces sebum secretion and alleviate the effect of skin lesion, and the synergism of compound preparation more enhances the anti-Cuo of medicine
Skin ulcer curative effect.Additionally, snake venom and baicalin are natural origin product, zest is low, it is to avoid the skin of resulted from chemical medicine is not
Good reaction.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Venin-derived in Elapidae snake venom, detailed description of the invention:
1g Elapidae snake venom is dissolved in 100ml deionized water, 4 DEG C, 5000rpm be centrifuged 15 minutes, take supernatant and carry out
Gel permeation chromatography；Sephadex-G-75 gel column selected by gel filtration, and post height 100cm, internal diameter 1.6cm, eluent is
The Spirit of Mindererus. of 0.05mol/L, elution speed is 16ml/h, within 10 minutes, collects 1 pipe；The toxin caused bleeding is removed after separation
Component, remaining composition carries out lyophilization, obtains the refined dry powder of Elapidae snake venom.
Baicalin extracts from Radix Scutellariae Chinese crude drug, detailed description of the invention:
100g medical material Radix Scutellariae, adds 500ml distilled water after pulverizing, cross 20 mesh sieves, add 2000U cellulose after being sufficiently stirred for
Enzyme 40 DEG C, pH4.5 enzymolysis sucking filtration after 24 hours, adds 60% alcohol reflux 2 times by sucking filtration gained solid, after concentrate drying is
Baicalin goods.
Elapidae snake venom dry powder and baicalin are mixed into the ratio of crude drug in terms of mass percent comes, Elapidae Serpentis
Poison dry powder proportion is 50-70%, and baicalin goods proportion is 30-50%.Detailed description of the invention:
Containing Elapidae snake venom dry powder 70g, baicalin goods 30g in embodiment 1, every 100g mixture；
Containing Elapidae snake venom dry powder 65g, baicalin goods 35g in embodiment 2, every 100g mixture；
Containing Elapidae snake venom dry powder 60g, baicalin goods 40g in embodiment 3, every 100g mixture；
Containing Elapidae snake venom dry powder 55g, baicalin goods 45g in embodiment 4, every 100g mixture；
Containing Elapidae snake venom dry powder 50g, baicalin goods 50g in embodiment 5, every 100g mixture；
The preparation method of the snake venom compound external-use agent of described anti-acne, comprises the steps: 50-70% Elapidae
Snake venom dry powder and 30-50% baicalin goods mix homogeneously, obtain crude drug；Take the crude drug of 1-8%, add adjuvant and/or
Carrier, mix homogeneously, obtain the snake venom compound external-use agent of anti-acne；Every 100g Elapidae snake venom refines dry powder and should comprise nerve
Toxin 6-12g, cardiotoxin 10-45g, cobra-venom factor 1.5-3g, Recombinant Naja naja atra NGF 0.2-0.5g；Often
In 100g baicalin goods, the content of baicalin is more than 98g.Described percentage ratio is mass percent.
In medicine of the present invention, the content ratio of Elapidae snake venom dry powder and baicalin mixture is in terms of mass percent comes,
In every 100g preparation, Elapidae snake venom dry powder and baicalin mixture content are 1-8%, add phase according to different preparation types
The adjuvant answered.Detailed description of the invention:
One, preparation Elapidae snake venom and the exterior-applied gel of baicalin Compound Resisting acne
Containing 1-8% Elapidae snake venom and baicalin mixture, the carbomer of 1.5%, 1.5% sweet in exterior-applied gel
Oil, 50% propylene glycol, sodium sorbate 0.25%, surplus is deionized water.
Embodiment 6:1% Elapidae snake venom and baicalin mixture, the carbomer of 1.5%, 1.5% glycerol, 50% the third
Glycol, sorbic acid 0.25%, add deionized water to 100%.
Embodiment 7:2% Elapidae snake venom and baicalin mixture, the carbomer of 1.5%, 1.5% glycerol, 50% the third
Glycol, sorbic acid 0.25%, add deionized water to 100%.
Embodiment 8:4% Elapidae snake venom and baicalin mixture, the carbomer of 1.5%, 1.5% glycerol, 50% the third
Glycol, sorbic acid 0.25%, add deionized water to 100%.
Embodiment 9:8% Elapidae snake venom and baicalin mixture, the carbomer of 1.5%, 1.5% glycerol, 50% the third
Glycol, sorbic acid 0.25%, add deionized water to 100%.
Two, preparation Elapidae snake venom and the medicinal external emulsifiable paste agent of baicalin Compound Resisting acne
Containing 1-8% Elapidae snake venom and baicalin mixture in exterior-applied emulsion.Exterior-applied emulsion makes oil-in-water type (O/
W), emulsifiable paste matrix is divided into oil phase and aqueous phase, each composition to calculate by mass percentage.
Embodiment 10: oil phase: stearic acid 1%, vaseline 10%, lanoline 8%g, hexadecanol 8%, glycerol monostearate
Vinegar 4%；Aqueous phase: sodium lauryl sulphate 2%, glycerol 13%, laurocapram 2.5%, ethylparaben 0.2%.
Surplus adds water to 100%.1% Elapidae snake venom and baicalin mixture add emulsifiable paste matrix.
Embodiment 11: oil phase: stearic acid 1%, vaseline 10%, lanoline 8%g, hexadecanol 8%, glycerol monostearate
Vinegar 4%；Aqueous phase: sodium lauryl sulphate 2%, glycerol 13%, laurocapram 2.5%, ethylparaben 0.2%.
Surplus adds water to 100%.2% Elapidae snake venom and baicalin mixture add emulsifiable paste matrix.
Embodiment 12: oil phase: stearic acid 1%, vaseline 10%, lanoline 8%g, hexadecanol 8%, glycerol monostearate
Vinegar 4%；Aqueous phase: sodium lauryl sulphate 2%, glycerol 13%, laurocapram 2.5%, ethylparaben 0.2%.
Surplus adds water to 100%.4% Elapidae snake venom and baicalin mixture add emulsifiable paste matrix.
Embodiment 13: oil phase: stearic acid 1%, vaseline 10%, lanoline 8%g, hexadecanol 8%, glycerol monostearate
Vinegar 4%；Aqueous phase: sodium lauryl sulphate 2%, glycerol 13%, laurocapram 2.5%, ethylparaben 0.2%.
Surplus adds water to 100%.8% Elapidae snake venom and baicalin mixture add emulsifiable paste matrix.
Three, preparation Elapidae snake venom and the Liposomal agents of baicalin Compound Resisting acne
Containing 1-8% Elapidae snake venom and baicalin mixture in external-use liposome agent.External-use liposome substrate respectively becomes
Divide and calculate by mass percentage.
Embodiment 14: lecithin and cholesterol mass ratio are 5.5:1, surfactant and total fat material mass ratio are 2:10,
Lecithin and dehydrated alcohol mass volume ratio are 3:100, and Elapidae snake venom and baicalin mixture with TL amount ratio are
0.1:10, preparation temperature is 66 DEG C.
Embodiment 15: lecithin and cholesterol mass ratio are 5.5:1, surfactant and total fat material mass ratio are 2:10,
Lecithin and dehydrated alcohol mass volume ratio are 3:100, and Elapidae snake venom and baicalin mixture with TL amount ratio are
0.2:10, preparation temperature is 66 DEG C.
Embodiment 16: lecithin and cholesterol mass ratio are 5.5:1, surfactant and total fat material mass ratio are 2:10,
Lecithin and dehydrated alcohol mass volume ratio are 3:100, and Elapidae snake venom and baicalin mixture with TL amount ratio are
0.4:10, preparation temperature is 66 DEG C.
Embodiment 17: lecithin and cholesterol mass ratio are 5.5:1, surfactant and total fat material mass ratio are 2:10,
Lecithin and dehydrated alcohol mass volume ratio are 3:100, and Elapidae snake venom and baicalin mixture with TL amount ratio are
0.8:10, preparation temperature is 66 DEG C.
Four, preparation Elapidae snake venom and the nanometer liposome agent of baicalin Compound Resisting acne
Containing 1-8% Elapidae snake venom and baicalin mixture in external nanometer liposome agent.External nanometer liposome
The each composition of substrate is calculated by mass percentage.
Embodiment 18: lecithin and cholesterol mass ratio are 4:1, surfactant and TL amount are than for 4:10, ovum phosphorus
Fat: dehydrated alcohol is 10:100, Elapidae snake venom and baicalin mixture and TL amount are than for 0.1:10, preparation temperature 60
DEG C, processing pressure is 130MPa, processes 2 times.
Embodiment 19: lecithin and cholesterol mass ratio are 4:1, surfactant and TL amount are than for 4:10, ovum phosphorus
Fat: dehydrated alcohol is 10:100, Elapidae snake venom and baicalin mixture and TL amount are than for 0.2:10, preparation temperature 60
DEG C, processing pressure is 130MPa, processes 2 times.
Embodiment 20: lecithin and cholesterol mass ratio are 4:1, surfactant and TL amount are than for 4:10, ovum phosphorus
Fat: dehydrated alcohol is 10:100, Elapidae snake venom and baicalin mixture and TL amount are than for 0.4:10, preparation temperature 60
DEG C, processing pressure is 130MPa, processes 2 times.
Embodiment 21: lecithin and cholesterol mass ratio are 4:1, surfactant and TL amount are than for 4:10, ovum phosphorus
Fat: dehydrated alcohol is 10:100, Elapidae snake venom and baicalin mixture and TL amount are than for 0.8:10, preparation temperature 60
DEG C, processing pressure is 130MPa, processes 2 times.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify,
All should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (6)
1. the snake venom compound external-use agent of an anti-acne, it is characterised in that containing the crude drug of 1-8%, described crude drug by
50-70% Elapidae snake venom dry powder and 30-50% baicalin goods are mixed to get, and described percentage ratio is by percent mass
Ratio；Every 100g Elapidae snake venom refines dry powder and should comprise neurotoxin 6-12g, cardiotoxin 10-45g, cobra-venom factor
1.5-3g, Recombinant Naja naja atra NGF 0.2-0.5g；In every 100g baicalin goods, the content of baicalin is more than 98g.
The snake venom compound external-use agent of anti-acne the most according to claim 1, it is characterised in that described Elapidae snake venom
For naja naja atra venom, Ophiophagus hannah (Cantor)., Bungarus toxin or bungarotoxin.
The snake venom compound external-use agent of anti-acne the most according to claim 1, it is characterised in that described Elapidae snake venom
Preparation method, comprise the steps: to be dissolved by Elapidae snake venom with deionized water, centrifugal, take supernatant and carry out separating pure
Changing, remove the toxin component caused bleeding in snake venom, remaining composition carries out lyophilization, obtains the refined dry of Elapidae snake venom
Powder.
The snake venom compound external-use agent of anti-acne the most according to claim 1, it is characterised in that described isolated and purified side
Method is gel filtration, and Sephadex-G-75 gel column selected by gel filtration, and post height 100cm, internal diameter 1.6cm, eluent is
The Spirit of Mindererus. of 0.05mol/L.
5. the snake venom compound external-use agent of the anti-acne described in claim 1 is compound gel, ointment, Liposomal agents or nanometer
Liposomal agents.
6. the preparation method of the snake venom compound external-use agent of the anti-acne described in claim 1, it is characterised in that include walking as follows
Rapid: by 50-70% Elapidae snake venom dry powder and 30-50% baicalin goods mix homogeneously, to obtain crude drug；Take 1-8%'s
Crude drug, adds adjuvant and/or carrier, mix homogeneously, obtains the snake venom compound external-use agent of anti-acne；Every 100g Elapidae Serpentis
The refined dry powder of poison should comprise neurotoxin 6-12g, cardiotoxin 10-45g, cobra-venom factor 1.5-3g, cobra neurotoxin
Somatomedin 0.2-0.5g；In every 100g baicalin goods, the content of baicalin is more than 98g；Described percentage ratio is percent mass
Ratio.
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| CN201610542079.XA CN106074611A (en) | 2016-07-08 | 2016-07-08 | A kind of snake venom compound external-use agent of anti-acne and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610542079.XA CN106074611A (en) | 2016-07-08 | 2016-07-08 | A kind of snake venom compound external-use agent of anti-acne and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007533A (en) * | 2017-04-25 | 2017-08-04 | 广州天济医药科技有限公司 | Cobra venom is used as the suppression acne cosmetics killed the purposes of propionibacterium acnes and be made from it |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN88100837A (en) * | 1988-02-11 | 1988-09-14 | 长春市生物工程应用技术研究所 | Cream with enzymes for subsiding acne |
| CN103751766A (en) * | 2013-12-06 | 2014-04-30 | 苏州人本药业有限公司 | Use of cobra venom cardiotoxins in preparation of drug for diminishing inflammation, easing pain and resisting arthritis |
-
2016
- 2016-07-08 CN CN201610542079.XA patent/CN106074611A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN88100837A (en) * | 1988-02-11 | 1988-09-14 | 长春市生物工程应用技术研究所 | Cream with enzymes for subsiding acne |
| CN103751766A (en) * | 2013-12-06 | 2014-04-30 | 苏州人本药业有限公司 | Use of cobra venom cardiotoxins in preparation of drug for diminishing inflammation, easing pain and resisting arthritis |
Non-Patent Citations (2)
| Title |
|---|
| 朱扣柱 等: "眼镜蛇毒抗炎成分研究概况", 《蛇志》 * |
| 李宏: "黄芩的生物活性及其在化妆品中的应用", 《香料香精化妆品》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007533A (en) * | 2017-04-25 | 2017-08-04 | 广州天济医药科技有限公司 | Cobra venom is used as the suppression acne cosmetics killed the purposes of propionibacterium acnes and be made from it |
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