CN106057628B - Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube - Google Patents
Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube Download PDFInfo
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- CN106057628B CN106057628B CN201610409896.8A CN201610409896A CN106057628B CN 106057628 B CN106057628 B CN 106057628B CN 201610409896 A CN201610409896 A CN 201610409896A CN 106057628 B CN106057628 B CN 106057628B
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- migration tube
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
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Abstract
Axial focused ion mobility spectrometer the invention discloses migration tube and under the atmospheric pressure with the migration tube, migration tube includes outer wall, outer wall includes spaced electrode retaining collar and dead ring, enter, exit inside diameter is consistent, dead ring wraps up electrode retaining collar wherein, symmetrical drift air inlet is provided with the outer wall of close exit end, the inside of migration tube is provided with focusing electrode, and focusing electrode is coaxial with migration tube and middle provided with axial aperture.Axial focused ion mobility spectrometer under atmospheric pressure with migration tube, including straight-through migration part, migration tube and the mass spectrograph connect is sequentially connected, the place that straight-through migration part is connected with migration tube is provided with ion gate, applies the voltage of setting on migration tube.By being optimized to the parameter of migration tube, and the foraminate focusing electrode of band for applying on electrode certain voltage and outside realizes ion axial focusing, the quantity by small ionic porogen is improved, so as to improve mass spectrographic detection performance and sensitivity.
Description
Technical field
The present invention relates to instrument analysis technology field, more particularly under a kind of migration tube and atmospheric pressure with the migration tube
Axial focusing ionic migration spectrometer.
Background technology
Ion mobility spectrometry (Ion mobility spectrometry, IMS) is that one kind is moved in the electric field based on gaseous ion
The difference of speed is moved the isolation technics that is characterized to chemical ion material, has that separating rate is fast, the letter of high sensitivity, structure
Single, the features such as reliability is high, in the analyzing of explosive detection, chemical warfare agent detection, drugs of abuse and volatile chemical, raw
The field extensive use such as thing macromolecular, have very for positive and negative ion detection and the separation of isomer, ion mobility spectrometry in addition
Good selectivity.Due to that need not use vacuum, the ion mobility spectrometry under atmospheric pressure is simple in construction, with the ion under other low pressure
Comparatively speaking migration spectral technology has higher resolution ratio, stronger to compound separating capacity similar in structure.
Mass spectrum is a kind of technology that charged molecule according to mass-to-charge ratio separate to analysis based on electromagnetic field, is widely used in doctor
The fields such as, pharmacy, large biological molecule, environmental protection science, material science and food security, it is in the accurate qualitative of compound
With the advantage for having uniqueness in terms of accurate quantification.Because mass spectrum can not realize the separation of isomer, by ion mobility spectrometry and
The combination of both mass spectrums can extend the analysis of complex mixture, expanded application scope.At present, domestic and international researcher has succeeded
Ion mobility spectrometry and flight time mass spectrum are combined, made correlative study in large biological molecule, explosive etc..But sensitivity
Relatively low is to perplex one of ion mobility spectrometry and the bottleneck of mass spectrometric hyphenated technique development under atmospheric pressure.
As a rule, migration tube is the important component of ionic migration spectrometer, and motion of the charged ion in migration tube is main
Influenceed by migration tube, migration tube on transverse direction, longitudinal electric field gradient, due to ion diffusion, Coulomb force and restraining force etc. because
Element, expansion strikes tube wall and causes losses of ions ion rapidly, and utilization rate is not high.Ion mobility spectrometry is only few with mass spectrographic combination
Part ion is transferred to mass spectrum and tested and analyzed, and mass spectrum is to be worked under high vacuum environment and ion mobility spectrometry is in atmospheric pressure
Lower operation.
The content of the invention
The purpose of the present invention is exactly to solve the above problems, there is provided a kind of migration tube and the atmospheric pressure with the migration tube
Lower axial focused ion mobility spectrometer, the performance of transference tube focusing is improved, solves ion in motion process because of storehouse
The problem of causing ion Expansion, ion diffusion etc. to cause ionic availability low is repelled in human relations.
To achieve these goals, the present invention adopts the following technical scheme that：
Migration tube, including outer wall, the outer wall include spaced electrode retaining collar and dead ring, enter, exit inside diameter is kept
Unanimously, each electrode retaining collar is connected with resistance, and resistance plays a part of divider, forms potential gradient；Dead ring is by electrode
Ring is wrapped up wherein, and symmetrical drift air inlet is provided with the outer wall close to exit end, and the migration tube is set in the port of export
There is a focusing electrode, the focusing electrode is coaxial with the migration tube and the middle aperture for being provided with axial direction.
The electrode retaining collar is square and material is stainless steel.
The electrode retaining collar has 20-30.
The thickness of the electrode retaining collar is 2-6cm.
Enter, exit inside diameter preferred scope is 10.0-25.0mm.
It is 4-8mm that the thickness of the dead ring, which selects scope,.
The hole diameter of the focusing electrode is 0.2-0.5mm.
Axial focused ion mobility spectrometer under atmospheric pressure with the migration tube, including it is sequentially connected the straight-through migration connect
Partly, migration tube and mass spectrograph, the place that is connected with migration tube of straight-through migration part are provided with ion gate, on the migration tube
Apply the voltage of setting.
At the front end 5-10cm of the straight-through migration part of ion gate distance.
The straight-through migration partial shape is square, using the exhausted of stainless steel electrode and 4-8mm thickness thick 5-10 2-6mm
Edge ring is stacked and formed, and is entered, exit inside diameter preferred scope 10.0-25.0mm.
Beneficial effects of the present invention：
Ion axial focusing is realized using the migration tube for applying certain voltage and certain internal diameter in migration area, reduces ion and exists
In transition process because Coulomb repulsion and ion diffusion collide migration inside pipe wall and caused by lose, and then improve ion utilize
Rate, mass spectrographic resolution ratio and sensitivity are improved, the invention belongs to instrument analysis technology.
The present invention is compact-sized, easy to use, effectively can focus on ion to effectively improve mass spectrum under atmospheric pressure
The resolution ratio of instrument and sensitivity.
By being optimized to the parameter of migration tube, and apply certain voltage on electrode and the port of export carries aperture
Focusing electrode realize ion axial focusing, the quantity by small ionic porogen is improved, so as to improve mass spectrographic detection performance and spirit
Sensitivity.
Brief description of the drawings
Fig. 1 is the cross-sectional view of migration tube；
Fig. 2 is the structural representation of axial focused ion mobility spectrometer under atmospheric pressure；
Fig. 3 is the external structure schematic diagram of migration tube；
Fig. 4 is with simion software verification focusing effect figures；
Fig. 5 (a) is electrode retaining collar front view, and Fig. 5 (b) is electrode retaining collar side view, and Fig. 5 (c) is electrode retaining collar isometric views；
Fig. 6 (a) is dead ring front view, and Fig. 6 (b) is dead ring axonometric drawing.
Wherein, 1 is straight-through migration part, and 2 be migration tube, and 3 be mass spectrograph, and 4 be ion gate, and 5 be drift air inlet, and 6 are
Aperture, 7 be focusing electrode, and 8 be electrode retaining collar, and 9 be ion, and 10 be dead ring, and 11 be boss.
Embodiment
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
In order to improve the utilization rate of ion and keep mass spectrographic condition of high vacuum degree, the present invention designs axially to be gathered under a kind of atmospheric pressure
Burnt ionic migration spectrometer, periodic axial direction is produced by the application certain voltage of the transference tube in certain internal diameter about
Beam electric field, it is different using flight track of the ion in axial constraint electric field and produce focussing force, it can reduce because of Coulomb repulsion
Caused by ion scatter and disappear, improve by the effective ion number of vacuum interface, so as to improve mass spectrographic resolution ratio and sensitivity.
As Figure 1-3, migration tube 2, stacked and formed by square stainless steel electrode ring 8 and dead ring, entered, exit inside diameter is protected
Hold in setting range, apply the voltage of setting on migration tube, the port of export of migration tube carries provided with a coaxial center position
The focusing electrode 7 of aperture, achieves axial focusing；Ion 9 in ion mobility spectrometry with foraminate focusing electrode 7 by entering
Enter mass spectrograph 3；Two symmetrical drift air inlets 5 are provided with close to the outer wall of the migration tube of outlet；Drift about what air inlet entered
Drift gas is the one or more in air, helium, hydrogen, nitrogen.
Combined using the thick square stainless steel electrode rings 8 of 20-30 2-6mm.Enter, exit inside diameter preferred scope is
10.0-25.0mm, separated by a dead ring between each two electrode retaining collar 8, be alternately arranged with each other composition, each to ensure with this
Electric-force gradient between electrode retaining collar 8.Insulation ring thickness preferred scope is 4-8mm, and internal diameter keeps one to electrode retaining collar 8 in axial direction
Cause, apply the voltage of setting on its migration tube.
The port of export of migration tube sets one with foraminate focusing electrode, a diameter of 0.2-0.5mm of aperture, ion 9
Mass spectrograph is entered by the hole, to improve the utilization rate of ion 9 and mass spectrographic sensitivity.
As shown in Fig. 5 (a) -5 (c), the profile of electrode retaining collar 8 is square, and there is square hole centre, into " returning " font, electrode
The left and right sides of ring 8 is additionally provided with square boss 11, to punch connection resistance at the position of boss 11, and is beneficial to and dead ring
More preferable extrusion fit is together.
As shown in Fig. 6 (a)-Fig. 6 (b), dead ring is just combined together with electrode retaining collar, and the profile of dead ring is also side
There is square hole shape, centre, and also into " returning " font, the left and right sides of dead ring is provided with square inner fovea part, a dead ring and
Two electrode retaining collar extrusion fits, such design structure opposed configuration is simple, assembly and disassembly are easy to maintenance, bearing capacity is high, can bear to rush
Hit load.
Axial focused ion mobility spectrometer, includes successively vertically from left to right under atmospheric pressure with the migration tube：
Straight-through migration part 1, Bradbury-Nielsen ion gates 4, migration tube 2, focusing electrode 7 and mass spectrograph 3 are square by metal
The constant internal diameter size of passage, apply voltage on its pipe, ion can realize focusing function, be connect so as to increase ion by mass spectrum
The ratio of mouth, and then strengthen the sensitivity of ion mobility spectrometry-GC-MS.
Straight-through migration part 1 is square, using the thick dead ring of thick 5-10 2-6mm stainless steel electrode ring and 4-8mm
Stacking forms, and enters, exit inside diameter preferred scope 10.0-25.0mm；Ion gate is at straight-through portion sub-headend 5-10cm.
The exit portion of migration tube 2 is smooth and constant inner diameter, close mass spectrograph, the edge of square migration tube are provided with collimation
Hole, preferably to connect into an entirety.Ion gate 4 is at the straight-through migration front end 5-10cm of part 1.
The present invention can make of various materials, but consider good chemical stability, corrosion resistance and electric conductivity, no
Rust steel and processing ceramic material are preferred making materials.
Present invention transmission and focusing are realized by pneumatics and electric power effect.Ion initially enters straight-through
Part 1 is migrated, subsequent ion enters migration tube 2 with air-flow, and aerodynamic force derives from a gas pressure source, from gas pressure source
Gas out is entered in migration tube by gas piping from drift air inlet 5, and focusing is by the parameter to migration tube
Optimize, and apply certain voltage on the electrode of migration tube 2 and focusing electrode 7 realizes the focusing of direction of principal axis.
Air-flow moves along hydraulically smooth surface, drives the air-flow containing object ion in migration tube 2 quickly to move, passes through focusing
Aperture 6 is passed through after the focused ion of electrode 7, is entered in mass spectrograph 3.
In order to verify the focusing effect of this system and optimum focusing parameter, using in the simulation softwares of Simion 8.0
SDS programs have carried out simulation calculation to this system；The software can emulate the simulation software of ion motion trace under atmospheric pressure.
The step of simulation calculation is:
In Solidworks 1 is pressed according to the actual size of transference tube:1 ratio establishes electrode system model, and
Save as STL forms；
Stl file is converted into the PA files available for simulation calculation in Simion 8.0；Set each electrode potential with
Mould is with the Potential Distributing curve in real transference tube；
Ion initial parameter is set, such as the generation position of ion, the mass-to-charge ratio of ion, the parameter such as electrically；
It is loaded under atmospheric pressure and emulates than SDS program；
Simulation calculation ion motion trace and the number of ions of electrode is reached to assess focusing effect.
Simulation calculation has been carried out to this system using the SDS programs in the simulation softwares of Simion 8.0, has calculated ion motion
Track and the number of ions for reaching electrode, as a result as shown in table 1.
The simion workbench result of calculations of table 1
The ring thickness that insulate as can be seen from Table 1 is 5mm, and internal diameter reaches the number of ions of electrode in the range of 12.5-22.5mm
Between 50-70, focusing effect is obvious；Insulation ring thickness is 6mm, and for internal diameter in the range of 12.5-22.5, its internal diameter is 15mm,
The ion populations of arrival electrode are most, and focusing effect is extremely notable.
With simion software verification focusing effects, as shown in figure 4, setting cation enters ion focusing system, just from
It is sub inevitable along electric field line direction to central motion, so as to serve the effect of ion focusing in X-direction.Simultaneously as Y-direction
On have certain electric-force gradient and focusing electrode, ion can be made to travel forward along the Y direction.Therefore, ion is before along the Y direction
While row, the focusing in X-direction is realized.
The present invention relates to a kind of ionic migration spectrometer of axial focusing under atmospheric pressure.It is excellent by being carried out to the parameter of migration tube
Change, and the foraminate focusing electrode of band for applying on electrode certain voltage and outside realizes ion axial focusing, improves
By the quantity of small ionic porogen, so as to mass spectrographic detection performance and sensitivity.
Although above-mentioned the embodiment of the present invention is described with reference to accompanying drawing, model not is protected to the present invention
The limitation enclosed, one of ordinary skill in the art should be understood that on the basis of technical scheme those skilled in the art are not
Need to pay various modifications or deformation that creative work can make still within protection scope of the present invention.
Claims (9)
1. migration tube, it is characterized in that, including outer wall, the outer wall include spaced electrode retaining collar and dead ring, enters, export in
Footpath is consistent, and each electrode retaining collar is connected with resistance, and dead ring wraps up electrode retaining collar wherein, close to exit end
Outer wall is provided with symmetrical drift air inlet, and the migration tube is provided with focusing electrode in the port of export, the focusing electrode with it is described
Migration tube is coaxial and middle provided with axial aperture, and by being optimized to the parameter of migration tube, and application is certain on electrode
Voltage and the foraminate focusing electrode of port of export band realize ion axial focusing, improve the quantity by small ionic porogen, from
And improve mass spectrographic detection performance and sensitivity.
2. a kind of migration tube as claimed in claim 1, it is characterized in that, the electrode retaining collar is square and material is stainless steel.
3. a kind of migration tube as claimed in claim 1, it is characterized in that, the electrode retaining collar has 20-30.
4. a kind of migration tube as claimed in claim 1, it is characterized in that, the thickness of the electrode retaining collar is 2-6cm.
5. a kind of migration tube as claimed in claim 1, it is characterized in that, enter, exit inside diameter preferred scope is 10.0-25.0mm.
6. a kind of migration tube as claimed in claim 1, it is characterized in that, it is 4-8mm that the thickness of the dead ring, which selects scope,.
7. a kind of migration tube as claimed in claim 1, it is characterized in that, the hole diameter of the focusing electrode is 0.2-0.5mm.
8. with axial focused ion mobility spectrometer under the atmospheric pressure of migration tube described in claim 1, it is characterized in that, including successively
Straight-through migration part, migration tube and the mass spectrograph being connected, the straight-through migration place that be connected with migration tube of part provided with from
Cervical orifice of uterus, apply the voltage of setting on the migration tube, utilize the migration tube for applying certain voltage and certain internal diameter in migration area real
Existing ion axial focusing, reduce ion in transition process because coulomb repulsion and ion diffusion collide migration inside pipe wall and caused by
Loss；
The straight-through migration partial shape is square, using the thick dead ring of thick 5-10 2-6mm stainless steel electrode and 4-8mm
Stacking forms, and enters, exit inside diameter preferred scope 10.0-25.0mm.
9. axial focused ion mobility spectrometer under atmospheric pressure according to claim 8, it is characterized in that, the ion gate distance
At the front end 5-10cm of straight-through migration part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610409896.8A CN106057628B (en) | 2016-06-13 | 2016-06-13 | Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube |
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| CN201610409896.8A CN106057628B (en) | 2016-06-13 | 2016-06-13 | Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube |
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| CN106057628A CN106057628A (en) | 2016-10-26 |
| CN106057628B true CN106057628B (en) | 2018-03-27 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106596705A (en) * | 2016-12-21 | 2017-04-26 | 中国科学院上海应用物理研究所 | High-temperature molten salt gas-phase component detection method and system |
| CN109243961B (en) * | 2018-09-30 | 2024-05-14 | 镇江华智睿安物联科技有限公司 | Microfluidic electrode ion migration tube and preparation method thereof |
| CN112309821A (en) * | 2019-07-25 | 2021-02-02 | 苏州微木智能系统有限公司 | Faraday disc, ion mobility tube and ion mobility spectrometer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102931046A (en) * | 2011-08-09 | 2013-02-13 | 中国科学院大连化学物理研究所 | Spatial focusing ion gate component and spatial focusing ion migration tube |
| CN103367092A (en) * | 2012-03-28 | 2013-10-23 | 中国人民解放军63975部队 | Ion migration spectrum instrument |
| CN103688164A (en) * | 2010-09-09 | 2014-03-26 | 艾森斯分析公司 | Method and apparatus for ionizing gases using uv radiation and electrons and identifying said gases |
| CN103688163A (en) * | 2011-04-27 | 2014-03-26 | 植入科学公司 | Ion mobility spectrometer device with embedded faims cells |
| CN104716006A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | Connector shared by ion migration spectrum and mass spectrum |
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- 2016-06-13 CN CN201610409896.8A patent/CN106057628B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103688164A (en) * | 2010-09-09 | 2014-03-26 | 艾森斯分析公司 | Method and apparatus for ionizing gases using uv radiation and electrons and identifying said gases |
| CN103688163A (en) * | 2011-04-27 | 2014-03-26 | 植入科学公司 | Ion mobility spectrometer device with embedded faims cells |
| CN102931046A (en) * | 2011-08-09 | 2013-02-13 | 中国科学院大连化学物理研究所 | Spatial focusing ion gate component and spatial focusing ion migration tube |
| CN103367092A (en) * | 2012-03-28 | 2013-10-23 | 中国人民解放军63975部队 | Ion migration spectrum instrument |
| CN104716006A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | Connector shared by ion migration spectrum and mass spectrum |
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