CN106057628A - Migration tube and ion mobility spectrometer with migration tube for axial focusing under atmospheric pressure - Google Patents
Migration tube and ion mobility spectrometer with migration tube for axial focusing under atmospheric pressure Download PDFInfo
- Publication number
- CN106057628A CN106057628A CN201610409896.8A CN201610409896A CN106057628A CN 106057628 A CN106057628 A CN 106057628A CN 201610409896 A CN201610409896 A CN 201610409896A CN 106057628 A CN106057628 A CN 106057628A
- Authority
- CN
- China
- Prior art keywords
- migration
- migration tube
- focusing
- atmospheric pressure
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
Abstract
The invention discloses a migration tube and an ion mobility spectrometer with the migration tube for axial focusing under atmospheric pressure. The migration tube comprises an outer wall, wherein the outer wall comprises electrode rings and insulating rings, which are arranged at intervals; the inner diameters of an inlet and an outlet are kept consistent; the insulating rings wrap the electrode rings; symmetrical drift air inlets are arranged in the outer wall of one end, close to the outlet; a focusing electrode is arranged in the migration tube and is coaxial with the migration tube; and an axial hole is arranged in the middle of the focusing electrode. The ion mobility spectrometer with the migration tube for axial focusing under the atmospheric pressure comprises a straight migration part, the migration tube and a mass spectrometer which are sequentially connected; an ion gate is arranged at the connected part of the straight migration part and the migration tube; and set voltage is applied to the migration tube. Ion axial focusing is achieved by optimizing parameters of the migration tube, applying certain voltage to the electrode and arranging the focusing electrode with the hole on the outer side; and the number of ions passing through the hole is increased, so that the mass spectrometry detection performance and sensitivity are improved.
Description
Technical field
The present invention relates to instrument analysis technology field, particularly relate under a kind of migration tube and the atmospheric pressure with this migration tube
Axial focusing ionic migration spectrometer.
Background technology
Ion mobility spectrometry (Ion mobility spectrometry, IMS) is that one is moved in the electric field based on gaseous ion
Move the difference isolation technics that chemical ion material is characterized of speed, have that separating rate is fast, highly sensitive, structure is simple
Single, reliability high, in explosive detection, chemical warfare agent detection, drugs of abuse and the analysis of volatile chemical, life
The fields such as thing macromole are extensively applied, and additionally for positive and negative ion detection and the separation of isomers, ion mobility spectrometry has very
Good selectivity.Owing to need not use vacuum, the ion mobility spectrometry simple in construction under atmospheric pressure, with the ion under other low pressure
Migrating spectral technology and Comparatively speaking have higher resolution, the compound separating power close to structure is higher.
Mass spectrum is that a kind of being carried out according to mass-to-charge ratio by charged molecule based on electromagnetic field separates the technology analyzed, and is widely used in doctor
The fields such as, pharmacy, biomacromolecule, environmental protection science, material science and food safety, its most qualitative at compound
With the advantage that accurate quantification aspect has uniqueness.Owing to mass spectrum can not realize the separation of isomers, by ion mobility spectrometry and
Both mass spectrums combine can extend the analysis of complex mixture, expanded application scope.At present, domestic and international researcher is the most successful
Ion mobility spectrometry is combined with flight time mass spectrum, has made correlational study at the aspect such as biomacromolecule, explosive.But sensitivity
Relatively low is one of bottleneck of ion mobility spectrometry and mass spectrometric hyphenated technique development under puzzlement atmospheric pressure.
As a rule, migration tube is the vitals of ionic migration spectrometer, and charged ion motion in migration tube is main
Affected by migration tube, migration tube on horizontal, longitudinal electric field gradient, due to ion diffusion, Coulomb force and restraining forces etc. because of
Element, ion expands rapidly and strikes tube wall and cause losses of ions, and utilization rate is the highest.Ion mobility spectrometry is the fewest with mass spectrographic combination
Part ion is transferred to mass spectrum to carry out detection and analyzes, and mass spectrum is to work under high vacuum environment and ion mobility spectrometry is at atmospheric pressure
Lower operation.
Summary of the invention
The purpose of the present invention is contemplated to solve the problems referred to above, it is provided that a kind of migration tube and the atmospheric pressure with this migration tube
Lower axial focusing ionic migration spectrometer, improves the performance that transference tube focuses on, solves ion in motor process because of storehouse
Human relations repulsion causes ion Expansion, ion diffusion etc. to cause the problem that ionic availability is low.
To achieve these goals, the present invention adopts the following technical scheme that
Migration tube, including outer wall, described outer wall includes spaced electrode retaining collar and dead ring, enter, exit inside diameter keep
Unanimously, each described electrode retaining collar is connected with resistance, and resistance plays the effect of potentiometer, forms potential gradient；Dead ring is by electrode
Ring is wrapped in wherein, is being provided with the drift air inlet of symmetry on the outer wall of exit end, and described migration tube sets at the port of export
Having focusing electrode, described focusing electrode is coaxial with described migration tube and centre is provided with axial aperture.
Described electrode retaining collar is square and material is rustless steel.
Described electrode retaining collar has 20-30.
The thickness of described electrode retaining collar is 2-6cm.
Enter, the preferred scope of exit inside diameter is 10.0-25.0mm.
The thickness of described dead ring selects scope to be 4-8mm.
The hole diameter of described focusing electrode is 0.2-0.5mm.
Axial focusing ionic migration spectrometer under atmospheric pressure with described migration tube, including being sequentially connected the straight-through migration connect
Partly, migration tube and mass spectrograph, the place that described straight-through migration part is connected with migration tube is provided with ion gate, on described migration tube
Apply the voltage set.
At the straight-through front end 5-10cm migrating part of described ion gate distance.
Described straight-through migration partial shape is square, uses the stainless steel electrode of 5-10 2-6mm thickness and the exhausted of 4-8mm thickness
Edge ring stacking forms, and enters, preferred scope 10.0-25.0mm of exit inside diameter.
Beneficial effects of the present invention:
Utilize the migration tube applying certain voltage and certain internal diameter in migration area to realize ion axial focusing, reduce ion and exist
Transition process spreads, because of Coulomb repulsion and ion, the loss colliding migration tube inwall and cause, and then improves ion utilization
Rate, improves mass spectrographic resolution and sensitivity, and this invention belongs to instrument analysis technology.
Present configuration is compact, easy to use, it is possible to effectively under atmospheric pressure focus on to be effectively improved mass spectrum by ion
The resolution of instrument and sensitivity.
By the parameter of migration tube is optimized, and on electrode, apply certain voltage and the port of export with aperture
Focusing electrode realize ion axial focusing, improve the quantity by little ionic porogen, thus improve mass spectrographic detection performance and spirit
Sensitivity.
Accompanying drawing explanation
Fig. 1 is the cross-sectional view of migration tube；
Fig. 2 is the structural representation of axial focusing ionic migration spectrometer under atmospheric pressure；
Fig. 3 is the external structure schematic diagram of migration tube；
Fig. 4 is for using simion software verification focusing effect figure；
Fig. 5 (a) is electrode retaining collar front view, and Fig. 5 (b) is electrode retaining collar side view, and Fig. 5 (c) is electrode retaining collar isometric views；
Fig. 6 (a) is dead ring front view, and Fig. 6 (b) is dead ring axonometric drawing.
Wherein, 1 migrates part for straight-through, and 2 is migration tube, and 3 is mass spectrograph, and 4 is ion gate, and 5 is drift air inlet, and 6 are
Aperture, 7 is focusing electrode, and 8 is electrode retaining collar, and 9 is ion, and 10 is dead ring, and 11 is boss.
Detailed description of the invention
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
In order to improve the utilization rate of ion and keep mass spectrographic condition of high vacuum degree, the present invention designs and axially gathers under a kind of atmospheric pressure
Burnt ionic migration spectrometer, is produced by the applying certain voltage at the transference tube of certain internal diameter the most about
Bundle electric field, utilizes ion flight track in axial constraint electric field different and produces focussing force, can reduce because of Coulomb repulsion
And the ion caused scatters and disappears, improve the effective ion number by vacuum interface, thus improve mass spectrographic resolution and sensitivity.
As Figure 1-3, migration tube 2, square stainless steel electrode ring 8 and dead ring stack and form, enter, exit inside diameter is protected
Hold in set point, migration tube applies set voltage, the port of export of migration tube be provided with a coaxial center position with
The focusing electrode 7 of aperture so that it is realize axial focusing；Ion 9 in ion mobility spectrometry enters by carrying foraminate focusing electrode 7
Enter mass spectrograph 3；Outer wall near the migration tube of outlet is provided with two symmetrical drift air inlets 5；Drift air inlet enters
Drift gas is one or more in air, helium, hydrogen, nitrogen.
Square stainless steel electrode ring 8 thick for 20-30 2-6mm is used to combine.Enter, the preferred scope of exit inside diameter is
10.0-25.0mm, is separated by a dead ring between each two electrode retaining collar 8, and be alternately arranged with each other composition, ensures each with this
Electric-force gradient between electrode retaining collar 8.The preferred scope of dead ring thickness is 4-8mm, and electrode retaining collar 8 internal diameter in axial direction keeps one
Cause, its migration tube applies the voltage set.
The port of export of migration tube arranges one and carries foraminate focusing electrode, a diameter of 0.2-0.5mm of aperture, ion 9
Mass spectrograph is entered, to improve ion 9 utilization rate and mass spectrographic sensitivity by this hole.
As shown in Fig. 5 (a)-5 (c), the profile of electrode retaining collar 8 is square, and there is square hole centre, becomes " returning " font, electrode
The left and right sides of ring 8 is additionally provided with square boss 11, in order to connects resistance in the punching of boss 11 position, and is beneficial to and dead ring
Preferably extruding is combined together.
As shown in Fig. 6 (a)-Fig. 6 (b), dead ring is just combined together with electrode retaining collar, the profile of the dead ring also side of being
Shape, there is a square hole centre, also becomes " returning " font, the left and right sides of dead ring to be provided with square inner fovea part, a dead ring and
Two electrode retaining collar extruding coordinate, and so structure opposed configuration is simple, mounting or dismounting are easy to maintenance, bearing capacity is high in design, can bear punching
Hit load.
Axial focusing ionic migration spectrometer under atmospheric pressure with described migration tube, includes the most successively:
Straight-through part 1, Bradbury-Nielsen ion gate 4, migration tube 2, focusing electrode 7 and the mass spectrograph 3 of migrating is square by metal
The constant internal diameter size of passage, applying voltage on its pipe, ion can be realized focusing function, thus increase ion and connect by mass spectrum
The ratio of mouth, and then strengthen the sensitivity of ion mobility spectrometry-GC-MS.
The straight-through part 1 that migrates is square, uses stainless steel electrode ring thick for 5-10 2-6mm and the dead ring of 4-8mm thickness
Stacking forms, and enters, preferred scope 10.0-25.0mm of exit inside diameter；At the straight-through part front end 5-10cm of ion gate distance.
The exit portion of migration tube 2 is smooth and constant inner diameter, and near mass spectrograph, the edge of square migration tube is provided with collimation
Hole, in order to preferably connect into an entirety.Ion gate 4 is at straight-through migration part 1 front end 5-10cm.
The present invention can make by various materials, but considers good chemical stability, corrosion resistance and electric conductivity, no
Rust steel and processing ceramic material are first-selected making materials.
Present invention transmission and focusing are all realized by pneumatics and electric power effect.Ion initially enters straight-through
Migrating part 1, ion enters migration tube 2 with air-flow subsequently, and aerodynamic force derives from a gas pressure source, from gas pressure source
Gas out enters migration tube through gas piping from drift air inlet 5, and focusing is by the parameter to migration tube
It is optimized, and on the electrode of migration tube 2, applies certain voltage and focusing electrode 7 realizes axial focusing.
Air-flow moves along hydraulically smooth surface, drives migration tube 2 to be contained within the air-flow rapid movement of object ion, by focusing on
Pass through aperture 6 after electrode 7 focused ion, enter in mass spectrograph 3.
In order to verify focusing effect and the optimum focusing parameter of this system, utilize in Simion 8.0 simulation software
SDS program has carried out simulation calculation to this system；This software can emulate the simulation software of ion motion trace under atmospheric pressure.
The step of simulation calculation is:
In Solidworks, the actual size according to transference tube sets up electrode system model in the ratio of 1:1, and
Save as STL form；
In Simion 8.0, stl file is converted into the PA file that can be used for simulation calculation；Set each electrode potential with
Mould is with the Potential Distributing curve in real transference tube；
Set ion initial parameter, such as the generation position of ion, the mass-to-charge ratio of ion, the parameter such as electrically；
It is loaded under atmospheric pressure and emulates ratio SDS program；
The number of ions of simulation calculation ion motion trace and arrival electrode is to assess focusing effect.
Utilize the SDS program in Simion 8.0 simulation software that this system has carried out simulation calculation, calculate ion motion
Track and the number of ions of arrival electrode, result is as shown in table 1.
Table 1 simion workbench result of calculation
Dead ring thickness is 5mm as can be seen from Table 1, and internal diameter, in the range of 12.5-22.5mm, arrives the number of ions of electrode
Between 50-70, focusing effect is obvious；Dead ring thickness is 6mm, and internal diameter is in the range of 12.5-22.5, and its internal diameter is 15mm,
The ion populations arriving electrode is most, and focusing effect is the most notable.
Use simion software verification focusing effect, as shown in Figure 4, set cation enter ion focusing system, just from
Son inevitable along electric field line direction to central motion, thus serve the effect of ion focusing in X-direction.Simultaneously as Y-direction
On have certain electric-force gradient and focusing electrode, ion can be made to travel forward along the Y direction.Therefore, ion is before along the Y direction
While row, it is achieved that in the focusing of X-direction.
The present invention relates to the ionic migration spectrometer of axial focusing under a kind of atmospheric pressure.By the parameter of migration tube is carried out excellent
Change, and the foraminate focusing electrode of band applying certain voltage and outside on electrode realizes ion axial focusing, improve
By the quantity of little ionic porogen, thus mass spectrographic detection performance and sensitivity.
Although the detailed description of the invention of the present invention is described by the above-mentioned accompanying drawing that combines, but not the present invention is protected model
The restriction enclosed, one of ordinary skill in the art should be understood that on the basis of technical scheme, and those skilled in the art are not
Need to pay various amendments or deformation that creative work can make still within protection scope of the present invention.
Claims (10)
1. migration tube, is characterized in that, including outer wall, described outer wall includes spaced electrode retaining collar and dead ring, in entering, exporting
Footpath keeps consistent, and each described electrode retaining collar is connected with resistance, and electrode retaining collar is wrapped in wherein by dead ring, near exit end
Outer wall is provided with the drift air inlet of symmetry, and described migration tube is provided with focusing electrode at the port of export, and described focusing electrode is with described
Migration tube is coaxial and centre is provided with axial aperture.
2. axial focusing ionic migration spectrometer under a kind of atmospheric pressure, is characterized in that, the described electrode retaining collar side of being
Shape and material be rustless steel.
3. axial focusing ionic migration spectrometer under a kind of atmospheric pressure, is characterized in that, described electrode retaining collar has
20-30.
4. axial focusing ionic migration spectrometer under a kind of atmospheric pressure, is characterized in that, the thickness of described electrode retaining collar
Degree is 2-6cm.
5. as claimed in claim 1 axial focusing ionic migration spectrometer under a kind of atmospheric pressure, is characterized in that, enter, exit inside diameter excellent
Selecting scope is 10.0-25.0mm.
6. axial focusing ionic migration spectrometer under a kind of atmospheric pressure, is characterized in that, the thickness of described dead ring
It is 4-8mm that degree selects scope.
7. axial focusing ionic migration spectrometer under a kind of atmospheric pressure, is characterized in that, described focusing electrode
Hole diameter is 0.2-0.5mm.
8. axial focusing ionic migration spectrometer under the atmospheric pressure with migration tube described in claim 1, is characterized in that, including successively
Straight-through migration part, migration tube and the mass spectrograph being connected, the place that described straight-through migration part is connected with migration tube be provided with from
Cervical orifice of uterus, described migration tube applies the voltage set.
9. axial focusing ionic migration spectrometer under the atmospheric pressure with migration tube described in claim 8, is characterized in that, described ion
At the straight-through front end 5-10cm migrating part of door distance.
10. axial focusing ionic migration spectrometer under the atmospheric pressure with migration tube described in claim 8, is characterized in that, described directly
The logical partial shape that migrates is square, uses the dead ring stacking of stainless steel electrode thick for 5-10 2-6mm and 4-8mm thickness to form,
Enter, preferred scope 10.0-25.0mm of exit inside diameter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610409896.8A CN106057628B (en) | 2016-06-13 | 2016-06-13 | Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610409896.8A CN106057628B (en) | 2016-06-13 | 2016-06-13 | Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106057628A true CN106057628A (en) | 2016-10-26 |
| CN106057628B CN106057628B (en) | 2018-03-27 |
Family
ID=57169991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610409896.8A Expired - Fee Related CN106057628B (en) | 2016-06-13 | 2016-06-13 | Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106057628B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106596705A (en) * | 2016-12-21 | 2017-04-26 | 中国科学院上海应用物理研究所 | High-temperature molten salt gas-phase component detection method and system |
| CN109243961A (en) * | 2018-09-30 | 2019-01-18 | 镇江华智睿安物联科技有限公司 | A kind of microflow control technique electrode ion migration tube and preparation method thereof |
| CN112309821A (en) * | 2019-07-25 | 2021-02-02 | 苏州微木智能系统有限公司 | Faraday disc, ion mobility tube and ion mobility spectrometer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102931046A (en) * | 2011-08-09 | 2013-02-13 | 中国科学院大连化学物理研究所 | Spatial focusing ion gate component and spatial focusing ion migration tube |
| CN103367092A (en) * | 2012-03-28 | 2013-10-23 | 中国人民解放军63975部队 | Ion migration spectrum instrument |
| CN103688163A (en) * | 2011-04-27 | 2014-03-26 | 植入科学公司 | Ion mobility spectrometer device with embedded faims cells |
| CN103688164A (en) * | 2010-09-09 | 2014-03-26 | 艾森斯分析公司 | Method and apparatus for ionizing gases using uv radiation and electrons and identifying said gases |
| CN104716006A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | Connector shared by ion migration spectrum and mass spectrum |
-
2016
- 2016-06-13 CN CN201610409896.8A patent/CN106057628B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103688164A (en) * | 2010-09-09 | 2014-03-26 | 艾森斯分析公司 | Method and apparatus for ionizing gases using uv radiation and electrons and identifying said gases |
| CN103688163A (en) * | 2011-04-27 | 2014-03-26 | 植入科学公司 | Ion mobility spectrometer device with embedded faims cells |
| CN102931046A (en) * | 2011-08-09 | 2013-02-13 | 中国科学院大连化学物理研究所 | Spatial focusing ion gate component and spatial focusing ion migration tube |
| CN103367092A (en) * | 2012-03-28 | 2013-10-23 | 中国人民解放军63975部队 | Ion migration spectrum instrument |
| CN104716006A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | Connector shared by ion migration spectrum and mass spectrum |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106596705A (en) * | 2016-12-21 | 2017-04-26 | 中国科学院上海应用物理研究所 | High-temperature molten salt gas-phase component detection method and system |
| CN109243961A (en) * | 2018-09-30 | 2019-01-18 | 镇江华智睿安物联科技有限公司 | A kind of microflow control technique electrode ion migration tube and preparation method thereof |
| CN112309821A (en) * | 2019-07-25 | 2021-02-02 | 苏州微木智能系统有限公司 | Faraday disc, ion mobility tube and ion mobility spectrometer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106057628B (en) | 2018-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8178833B2 (en) | High-flow tube for sampling ions from an atmospheric pressure ion source | |
| CN102067273A (en) | Mass spectrometer | |
| CN106057628A (en) | Migration tube and ion mobility spectrometer with migration tube for axial focusing under atmospheric pressure | |
| US20090321655A1 (en) | Ion Transfer Tube with Spatially Alternating DC Fields | |
| US20080116371A1 (en) | Apparatus and method for providing ions to a mass analyzer | |
| US8373118B2 (en) | Atmospheric pressure ionization inlet for mass spectrometers | |
| CN106340437A (en) | Mass spectrometer and method used to reduce ion loss and post-stage vacuum load | |
| EP3155641B1 (en) | Ion guide | |
| WO2018224049A1 (en) | Ion mobility analyzer and analysis method | |
| US20110072772A1 (en) | Skimmer for Concentrating an Aerosol and Uses Thereof | |
| JP2017152368A (en) | Quadrupole mass spectrometer | |
| US10770279B2 (en) | Ion transfer apparatus | |
| US20180166268A1 (en) | Ionization and ion introduction device for mass spectrometer | |
| US8859960B2 (en) | Method for transmitting ions and carrier gas between mutually facing curved electrodes | |
| CN105679636B (en) | Focused ion guiding device and mass spectrometer | |
| CN105679637A (en) | Atmospheric pressure ion source interface of mass spectrometer | |
| JP7018525B2 (en) | Ion guide for mass spectrometer and ion source using it | |
| Mayer et al. | Ion transfer from an atmospheric pressure ion funnel into a mass spectrometer with different interface options: Simulation‐based optimization of ion transmission efficiency | |
| CN104282525A (en) | Ion focusing transmission lens under atmosphere pressure | |
| Liu et al. | Optimization design of drift tube for ion mobility spectrometer based on simulation of drift electric field | |
| US9236232B2 (en) | Multi-bore capillary for mass spectrometer | |
| JP2016011847A (en) | Ionization chamber | |
| CN214672497U (en) | Time-of-flight mass analyzer | |
| JPWO2021176986A5 (en) | ||
| CN104201084B (en) | Closed type molecular adduct isotope ion generator |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180327 Termination date: 20190613 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |