CN103367092A - Ion migration spectrum instrument - Google Patents
Ion migration spectrum instrument Download PDFInfo
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- CN103367092A CN103367092A CN 201210085709 CN201210085709A CN103367092A CN 103367092 A CN103367092 A CN 103367092A CN 201210085709 CN201210085709 CN 201210085709 CN 201210085709 A CN201210085709 A CN 201210085709A CN 103367092 A CN103367092 A CN 103367092A
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Abstract
The invention discloses an ion migration spectrum instrument comprising an ion source electrode, a focus guiding electrode and an ion storage electrode, wherein the focus guiding electrode is arranged at one side of the ion source electrode, the ion storage electrode is arranged at one side of the focus guiding electrode, and the side of the focus guiding electrode is far away from the ion source electrode. The voltage of the focus guiding electrode and the ion storage electrode is controlled, and migration pipe work control is realized. At an ion storage phase, an ionized zone generates a lot of ions which are stored at an area between the focus guiding electrode and the ion storage electrode; at an ion lead-out phase, ions enter a migration zone in a very short time. An ion storage structure of the ion migration spectrum instrument is characterized in that stored ions can be led into the migration zone in a very short time; a net structure of the ion storage electrode guarantees that the stored ions do not overflow because excessive ions are stored; the structure can improve ion utilization rate of the migration pipe to 10% to 20%, and therefore detection sensitivity of the migration pipe is improved.
Description
Technical field
The present invention relates to a kind of ionic migration spectrometer and ion storage and deriving method that is applied to drugs and explosive detection, belong to the safety detection technology field.
Background technology
Usually in Ion mobility spectrometry, the ion fence gate in the migration tube adopts the Bradbury-Nielson structure.In this ion fence gate, the fine wire of tension is arranged with very little spaced and parallel at same plane, and two groups of wires that are communicated with separately structurally are spaced apart with interdigital form, and electrically insulated from one another ground is fixed on nonconducting support together.Must strain wire when wire is installed, but wire is easy to break.Because wiry expanding with heat and contract with cold also may cause lax or fracture wiry.No matter adopt which kind of design, if there is not parallel, bending or the other defect of tinsel, all can cause the degradation of ion fence gate and migration tube.Generally speaking, under the control of ion fence gate, within the time of every 20ms～30ms, there is the time ion of 300 μ s to enter the migration area from reaction zone.Like this, be used to measure with regard to only having 1% ion, the ion utilance is very low.The design of this ion fence gate is subject to puzzlement and the restriction of complexity that duty ratio, minimum pulse width, migration tube install and the intrinsic factor such as expensive.
In order to improve the ion utilance of migration tube, reduce the difficulty of assembling, someone has proposed the ion storage structure and has replaced traditional ion fence gate.When ion gate was in closed condition, traditional ion fence gate was by horizontal electric field, was neutralized so that ion hits on wire; The ion storage structure is then got up the ion storage that the ionized region drift is come, until ion gate switches to open mode, by electric field action, makes the ion that stores enter the migration area again.
United States Patent (USP) 5200614 discloses a kind of migration tube of ion storage structure.In this design, although ionized region and ion storage district are integrated, simplify the structure, in further using, brought inconvenience.Because negative ions accumulates in the ion storage district simultaneously, their composite action can cause the loss of ion, affects the sensitivity of migration tube.Simultaneously, this structure needs the long time ion in ion storage district could be sent into the migration area, thereby causes the broadening of ion mobility spectrometry, affects the resolution of migration tube.
Chinese patent 200710304330.x has proposed improvement project, so that the ion of storage can freely be distributed in the ion storage district, and is not subjected to the impact of external electrical field by electric field shielding.Yet because the effect of electric field shielding, the guiding focusing electrode is difficult to effectively play a role, and causes the ion of memory block to need the long period just can enter the migration area, thereby has restricted resolution and the sensitivity of instrument.
Summary of the invention
Based on the deficiencies in the prior art, the present invention proposes a kind of novel ionic migration spectrometer on the theoretical foundation of relevant ions storage organization, can effectively improve ion utilance to 10%～20%, the detection performance of Integral lifting ionic migration spectrometer.Its control method, manufacturing process are fairly simple, can effectively reduce cost.
Solving the not enough technical scheme that adopts is:
Ionic migration spectrometer of the present invention comprises ion source electrode 1, focuses on guiding electrode 4, ion storage electrode 5;
Focus on guiding electrode 4 and combined surface spraying one deck insulating varnish by stainless horn-like structure and circulus; Being arranged near ion source electrode 1 has a side of interior chamfering, and horn-like structure is from becoming gradually large near a side direction of ion source electrode 1 away from a side of ion source electrode 1;
Focus on the circulus of guiding electrode 4, have the effect of shielding external electrical field, guarantee that the electric field in ion storage district is almost nil, thereby so that ion freely distribute in the ion storage district;
The cavernous structure of ion storage electrode 5 stainless steel cloths comprises hexagonal hole, circular port or square hole; It is online that the too much ion in ion storage district will strike the stainless steel wire of ion storage electrode 5, the ion that has guaranteed the ion storage district can " overflowing " phenomenon not occur because having stored too much ion, prevent from entering the migration area at ion storage stage ion, also avoided the migration tube receiving terminal simultaneously because the detection electric current is excessive and may cause the problem that burns out signal amplification and Acquisition Circuit;
Ring-type insulating interlayer 7 is polytetrafluoroethylene or PEEK material between focusing guiding electrode 4 and the ion storage electrode 5, its thickness is less than 4mm, like this, the thickness of insulating interlayer 7 defines the axial width in ion storage district, so that ion distribution is at thinner one deck, focus between guiding electrode and the ion storage electrode simultaneously and can form stronger electric field, be conducive to potential pulse and in a short period of time ion imported the migration area.
The control method of ionic migration spectrometer of the present invention within a work period (20～30ms) comprise that ion storage stage, ion derive stage and transition stage:
The ion storage stage, apply voltage to focusing on guiding electrode 4 and ion storage electrode 5, so that it is less than or equal to the voltage that applies on electrode 3 and the electrode 6, to form electromotive force " depression ", in the ion storage structure, this stage continues 200～300 μ s with ion storage;
Ion is derived the stage, apply voltage to focusing on guiding electrode 4 and ion storage electrode 5, so that it is higher than the voltage that applies on electrode 3 and the electrode 6, and focuses on voltage on the guiding electrode 4 and be higher than voltage on the ion storage electrode 5, be stored in ion in the ion storage structure with derivation;
Transition stage, apply voltage to focusing on guiding electrode 4 and ion storage electrode 5, so that being higher than, the voltage of ion storage electrode 5 focuses on the voltage that applies on guiding electrode 4, electrode 3 and the electrode 6, cause the distortion of migration area front end electric field with the saltus step of avoiding ion storage structure electrode voltage, this stage continues 2000～4000 μ s;
After the transition stage, ionic migration spectrometer will enter the ion storage stage in next cycle.
The invention has the beneficial effects as follows to have solved in the past that the ion storage structure is difficult to effectively the ion of storage be imported in a short period of time the problem of migration area, thereby improve the ion utilance of instrument.Studies show that, the present invention can be increased to 10%～20% with the ion utilance of migration tube, has also guaranteed simultaneously the resolution of migration tube, and the detection performance of migration tube is had a distinct increment.
Description of drawings
The structural representation of Fig. 1 ionic migration spectrometer
The structural representation of Fig. 2 ion source electrode
Fig. 3 A is according to the exploded view of the ion storage structure of the embodiment of the invention
Fig. 3 B is according to the end view of the ion storage structure of the embodiment of the invention
Electrode is at the voltage schematic diagram in ion storage stage in Fig. 4 migration tube
Electrode is derived the voltage schematic diagram in stage in Fig. 5 migration tube at ion
Electrode is at the voltage schematic diagram of transition stage in Fig. 6 migration tube
Focus on the change in voltage figure of guiding electrode and ion storage electrode in Fig. 7 ion storage structure
Wherein, 1. ion source electrode; 2. drift rings electrode; 3. drift rings electrode; 4. focus on the guiding electrode; 5. ion storage electrode; 6. drift rings electrode; 7. ring-type insulating interlayer; 8. ion source electrode cutaway view; 9. ion source electrode end view; 10. focus on guiding electrode cutaway view; 11. ring-type insulating interlayer cutaway view; 12. ion storage electrode cutaway view; 13. focus on guiding electrode end view; 14. ring-type insulating interlayer end view; 15. ion storage electrode end view; A. ionization reaction district; B. ion storage district; C. migration area.
Embodiment
The present invention can be applicable to positive ion mode and the negative ion mode of migration tube in the ionic migration spectrometer, and the below is take the positive ion mode of migration tube as example, and the present invention is described further to reach by reference to the accompanying drawings embodiment.
Fig. 1 is the ion storage structural representation of the ionic migration spectrometer (IMS) according to the embodiment of the invention.As shown in Figure 1, comprise the ion source electrode 1 that is arranged in order, focus on guiding electrode 4 and ion storage electrode 5 according to the ion storage structure of the ionic migration spectrometer of the embodiment of the invention.
As shown in Figure 2, ionization source electrode 1 is that stainless steel is cylindric, near a side that focuses on guiding electrode 4 interior chamfering is arranged.Such design, the product ion that is conducive to ionized region moves to the migration tube rear end under the effect of electric field.According to embodiments of the invention, be close to the inwall of ionization source electrode and place radioactive source Ni
63Paillon foil.
Respectively exploded view and the end view of ion storage structure such as Fig. 3 A and Fig. 3 B.Focus on guiding electrode 4 and be comprised of stainless horn-like structure and circulus, horn-like electrode middle with hole becomes greatly from the side direction of adjoining ion source electrode 1 side away from ion source electrode 1, gradually at ion derivation stage formation focusing electric field; Focus on guiding electrode surface spraying one deck insulating varnish, prevent that ionic bombardment is neutralized to focusing on the guiding electrode.Ion storage electrode 5 is that transmitance is the pole plate more than 80%, is comprised of stainless steel cloth and stainless steel ring, and the mesh of stainless steel cloth comprises the hole of various patterns, such as hexagonal hole, circular hole etc.Focus on the ring-type insulating interlayer 7 that has polytetrafluoroethylene or PEEK material to consist of between guiding electrode 4 and the ion storage electrode 5.Focus on the spacing of guiding electrode 4 and ion storage electrode 5, namely the thickness of ring-type insulating interlayer 7 should be less than 4mm.The space that focuses between guiding electrode 4 and the ion storage electrode 5 is the ion storage district, and in the ion storage stage, this intra-zone forms without electric field region.
The work of ion storage structure is divided into three phases in the one-period: ion storage stage, ion are derived stage, transition stage.Only change the voltage that focuses on guiding electrode 4 and ion storage electrode 5 in the whole cycle, the voltage on other electrodes keeps immobilizing.Fig. 4 is according to each electrode of migration tube of embodiment of the invention voltage schematic diagram in the ion storage stage.As shown in Figure 4, the voltage linear on ion source electrode 1, electrode 2, the electrode 3 successively decreases.Begin to aperture plate from electrode 6, the voltage on the electrode is linear decrease also.In the ion storage stage, the voltage that focuses on guiding electrode 4 and ion storage electrode 5 is less than or equal to the voltage V of electrode 3
0, and be lower than the voltage V of electrode 6
1Like this, under the effect of electric field, the ion that is derived from ionized region will enter the ion storage district continuously.
Fig. 5 is the voltage schematic diagram in the stage of deriving at ion according to each electrode of migration tube of the embodiment of the invention.As shown in Figure 5, improve the voltage that focuses on guiding electrode 4 and ion storage electrode 5, so that focus on the voltage that the voltage of guiding electrode 4 is higher than ion storage electrode 5, the voltage of ion storage electrode 5 is higher than the voltage V of electrode 6
1Like this, the ion that is stored can enter the migration area in a short period of time.
Fig. 6 is according to each electrode of migration tube of embodiment of the invention voltage schematic diagram in transition stage.As shown in Figure 6, the magnitude of voltage in ion storage stage is returned in the voltage drop that focuses on guiding electrode 4, and the voltage of ion storage electrode 5 is kept the magnitude of voltage that ion is derived the stage.The electric field that guarantees the migration area front end can not be distorted because of the sudden change of ion storage structure electrode voltage, and impact is in the motion of the ion of migration area front end, thereby has avoided the broadening of instrument signal.
Fig. 7 is the change in voltage figure that focuses on guiding electrode 4 and ion storage electrode 5.The potential pulse that focuses on guiding electrode 4 is (t
1～t
2), the potential pulse of ion storage electrode 5 is (t
1～t
3).According to actual needs, focus on the voltage pulse width of guiding electrode 4 and ion storage electrode 5 at ion storage stage t
1, ion derives stage (t
1～t
2) and transition stage (t
2～t
3) be adjustable.Preferably, a work period is 30ms, and wherein the ion derivation duration in stage is 300 μ s, and the transition stage duration is 4000 μ s.
Claims (4)
1. an ionic migration spectrometer is characterized in that this spectrometer comprises ion source electrode (1), focuses on guiding electrode (4), ion storage electrode (5);
Ion source electrode (1) is become by stainless steel tubular structural group, near a side that focuses on guiding electrode (4) interior chamfering is arranged;
Focusing on guiding electrode (4) is combined by stainless horn-like structure and circulus, being arranged near ion source electrode (1) has a side of interior chamfering, and horn-like structure is from becoming gradually large near a side direction of ion source electrode (1) away from a side of ion source electrode (1);
Ion storage electrode (5) is arranged on that side away from ion source electrode (1) that focuses on guiding electrode (4), is comprised of stainless steel cloth and stainless steel ring;
Ring-type insulating interlayer (7) is polytetrafluoroethylene or PEEK material between focusing guiding electrode (4) and the ion storage electrode (5), and its thickness is less than 4mm.
2. ionic migration spectrometer as claimed in claim 1 is characterized in that focusing on guiding electrode (4) and is stainless steel material, surface spraying one deck insulating varnish.
3. ionic migration spectrometer as claimed in claim 1 is characterized in that the cavernous structure of ion storage electrode (5) stainless steel cloth comprises hexagonal hole, circular port or square hole.
4. the control method of an ionic migration spectrometer is characterized in that the method comprises that ion storage stage, ion derive stage and transition stage:
The ion storage stage, apply voltage to focusing on guiding electrode (4) and ion storage electrode (5), so that it is less than or equal to the voltage that applies on electrode (3) and the electrode (6), to form electromotive force " depression ", in the ion storage structure, this stage continues 200～300 μ s with ion storage;
Ion is derived the stage, apply voltage to focusing on guiding electrode (4) and ion storage electrode (5), so that it is higher than the voltage that applies on electrode (3) and the electrode (6), and focus on voltage on the guiding electrode (4) and be higher than voltage on the ion storage electrode (5), be stored in ion in the ion storage structure with derivation;
Transition stage, apply voltage to focusing on guiding electrode (4) and ion storage electrode (5), so that being higher than, the voltage of ion storage electrode (5) focuses on the voltage that applies on guiding electrode (4), electrode (3) and the electrode (6), cause the distortion of migration area front end electric field with the saltus step of avoiding ion storage structure electrode voltage, this stage continues 2000～4000 μ s;
After the transition stage, ionic migration spectrometer will enter the ion storage stage in next cycle.
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| CN 201210085709 CN103367092A (en) | 2012-03-28 | 2012-03-28 | Ion migration spectrum instrument |
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|---|---|---|---|
| CN 201210085709 CN103367092A (en) | 2012-03-28 | 2012-03-28 | Ion migration spectrum instrument |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102903598A (en) * | 2012-10-24 | 2013-01-30 | 公安部第三研究所 | Method for improving traditional ion transference tube sensitivity |
| CN105738461A (en) * | 2014-12-30 | 2016-07-06 | 莫福探测仪器有限责任公司 | Ion mobility spectrometer and method of using the same |
| CN106057628A (en) * | 2016-06-13 | 2016-10-26 | 塔里木大学 | Migration tube and ion mobility spectrometer with migration tube for axial focusing under atmospheric pressure |
| CN107393796A (en) * | 2017-06-16 | 2017-11-24 | 上海集成电路研发中心有限公司 | A kind of ion launcher and method for increasing ion implanting line |
| CN108133877A (en) * | 2017-12-12 | 2018-06-08 | 中国科学院合肥物质科学研究院 | It is a kind of that there is the highly sensitive ionic migration spectrometer of ion binding and method |
| CN108335964A (en) * | 2017-01-20 | 2018-07-27 | 广州智纯科学仪器有限公司 | Ion mobility spectrometry and flight time mass spectrum combined instrument and its connecting interface structure |
| GB2560818A (en) * | 2017-03-08 | 2018-09-26 | Bruker Daltonik Gmbh | Ion mobility spectrometer |
| CN108807130A (en) * | 2018-05-03 | 2018-11-13 | 塔里木大学 | A kind of migration tube and ionic migration spectrometer for ionic migration spectrometer |
| CN112309821A (en) * | 2019-07-25 | 2021-02-02 | 苏州微木智能系统有限公司 | Faraday disc, ion mobility tube and ion mobility spectrometer |
| CN112924531A (en) * | 2021-01-28 | 2021-06-08 | 上海奕瑞光电子科技股份有限公司 | Ion mobility spectrometer migration tube, operation method and ion mobility spectrometer |
| US11235329B2 (en) | 2017-08-10 | 2022-02-01 | Rapiscan Systems, Inc. | Systems and methods for substance detection using thermally stable collection devices |
| US11609214B2 (en) | 2019-07-31 | 2023-03-21 | Rapiscan Systems, Inc. | Systems and methods for improving detection accuracy in electronic trace detectors |
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- 2012-03-28 CN CN 201210085709 patent/CN103367092A/en active Pending
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102903598B (en) * | 2012-10-24 | 2015-04-15 | 公安部第三研究所 | Method for improving traditional ion transference tube sensitivity |
| CN102903598A (en) * | 2012-10-24 | 2013-01-30 | 公安部第三研究所 | Method for improving traditional ion transference tube sensitivity |
| CN105738461A (en) * | 2014-12-30 | 2016-07-06 | 莫福探测仪器有限责任公司 | Ion mobility spectrometer and method of using the same |
| CN106057628A (en) * | 2016-06-13 | 2016-10-26 | 塔里木大学 | Migration tube and ion mobility spectrometer with migration tube for axial focusing under atmospheric pressure |
| CN106057628B (en) * | 2016-06-13 | 2018-03-27 | 塔里木大学 | Axial focused ion mobility spectrometer under migration tube and atmospheric pressure with the migration tube |
| CN108335964A (en) * | 2017-01-20 | 2018-07-27 | 广州智纯科学仪器有限公司 | Ion mobility spectrometry and flight time mass spectrum combined instrument and its connecting interface structure |
| US10648946B2 (en) | 2017-03-08 | 2020-05-12 | Bruker Daltonik Gmbh | Ion mobility spectrometer |
| GB2560818A (en) * | 2017-03-08 | 2018-09-26 | Bruker Daltonik Gmbh | Ion mobility spectrometer |
| CN107393796B (en) * | 2017-06-16 | 2019-08-20 | 上海集成电路研发中心有限公司 | A kind of ion launcher and method increasing ion implanting line |
| CN107393796A (en) * | 2017-06-16 | 2017-11-24 | 上海集成电路研发中心有限公司 | A kind of ion launcher and method for increasing ion implanting line |
| US11235329B2 (en) | 2017-08-10 | 2022-02-01 | Rapiscan Systems, Inc. | Systems and methods for substance detection using thermally stable collection devices |
| CN108133877A (en) * | 2017-12-12 | 2018-06-08 | 中国科学院合肥物质科学研究院 | It is a kind of that there is the highly sensitive ionic migration spectrometer of ion binding and method |
| CN108133877B (en) * | 2017-12-12 | 2021-05-25 | 中国科学院合肥物质科学研究院 | High-sensitivity ion mobility spectrometer with ion binding function and method |
| CN108807130A (en) * | 2018-05-03 | 2018-11-13 | 塔里木大学 | A kind of migration tube and ionic migration spectrometer for ionic migration spectrometer |
| CN108807130B (en) * | 2018-05-03 | 2020-02-14 | 塔里木大学 | Migration tube for ion mobility spectrometer and ion mobility spectrometer |
| CN112309821A (en) * | 2019-07-25 | 2021-02-02 | 苏州微木智能系统有限公司 | Faraday disc, ion mobility tube and ion mobility spectrometer |
| US11609214B2 (en) | 2019-07-31 | 2023-03-21 | Rapiscan Systems, Inc. | Systems and methods for improving detection accuracy in electronic trace detectors |
| CN112924531A (en) * | 2021-01-28 | 2021-06-08 | 上海奕瑞光电子科技股份有限公司 | Ion mobility spectrometer migration tube, operation method and ion mobility spectrometer |
| CN112924531B (en) * | 2021-01-28 | 2023-07-28 | 上海奕瑞光电子科技股份有限公司 | Ion mobility spectrometer migration tube, operation method and ion mobility spectrometer |
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Application publication date: 20131023 |