CN104282525A - Ion focusing transmission lens under atmosphere pressure - Google Patents
Ion focusing transmission lens under atmosphere pressure Download PDFInfo
- Publication number
- CN104282525A CN104282525A CN201310272797.6A CN201310272797A CN104282525A CN 104282525 A CN104282525 A CN 104282525A CN 201310272797 A CN201310272797 A CN 201310272797A CN 104282525 A CN104282525 A CN 104282525A
- Authority
- CN
- China
- Prior art keywords
- stainless steel
- ion
- steel electrode
- transmission lens
- electrode ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/067—Ion lenses, apertures, skimmers
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention relates to a mass spectrometer, and particularly to an ion focusing transmission lens under an atmosphere pressure. The ion focusing transmission lens comprises stainless steel electrode rings, insulating medium rings and a stainless steel outer cylinder. The stainless steel outer cylinder has a closed cylindrical structure. The left end and the right end of the stainless steel outer cylinder are respectively provided with an ion inlet and an ion outlet. The stainless steel electrode rings and the insulating medium rings respectively have an annular structure, and the numbers of the stainless steel electrode rings and the insulating medium rings are respectively two or more than three. Furthermore the stainless steel electrode rings and insulating medium rings are separately, coaxially and parallelly arranged in the stainless steel outer cylinder at the end which is next to the ion inlet. An insulating medium layer is arranged between the stainless steel electrode rings and the stainless steel outer cylinder. The ion inlet, the stainless steel electrode rings and the ion outlet are arranged parallelly and coaxially with one another. The ion focusing transmission lens under the atmosphere pressure has functions of: realizing compact structure and convenient use, effectively focusing the ions under the atmosphere pressure, and improving sensitivity and measurement accuracy of the mass spectrometer.
Description
Technical field
The present invention relates to mass spectrometer, an ion focusing transmission lens specifically under atmospheric pressure, this ion focusing transmission lens compact conformation, easy to use, effectively ion under atmospheric pressure transmission be can be focused on, mass spectrometric sensitivity and measuring accuracy strengthened.
Background technology
Original position, harmless, on-the-spot, to analyze fast be the development trend of on-line monitoring analytical technique of mass spectrum, to complex sample direct ion under without the need to the condition of sample pre-treatments, greatly can improve the efficiency of mass spectral analysis, accelerate the speed of on-line analysis.Atmospheric pressure ionization technology general reference, without the need to sample pretreatment, under atmospheric pressure carries out direct ionization to sample, and then the emerging mass-spectrometric technique that rapid analysis detects.Direct Analysis in Real Time (DART) ionization technique that electron spray desorption ionization (DESI) technology that Cooks in 2004 etc. propose and Cody in 2005 etc. propose, facilitates the development of atmospheric pressure ionization technology greatly.In ensuing several years, because analysis speed is fast, inspection sensitivity advantages of higher, this technology obtains flourish, successively emerges again nearly 30 kinds of atmospheric pressure ionization sources.
But no matter being DESI or DART, all there is ion collection efficiency low, is difficult to the shortcomings such as accurate quantitative analyses in nearly all existing atmospheric pressure ionization technology.Why atmospheric pressure ionization source has these drawbacks, and under reason will ascribe atmospheric pressure to greatly, environmental gas is comparatively complicated, and the ion produced by atmospheric pressure ionization source, with background gas, strong collision occurs, and is difficult to realize effective focusing.This makes the determinand ion produced, and only has a little part can enter in the middle of mass spectrometer.Moreover, the ion entering into mass spectrometer is not only complicated, and comparatively disperses.This brings larger difficulty to ensuing analyte detection process.This is also a key factor of puzzlement atmospheric pressure ionization source extensive use more.Iff dependence electric field action, the effect of ion focusing is unsatisfactory.
Accordingly, the auxiliary transmission of air-flow is utilized in the present invention, by increasing aspiration pump, laminar flow is formed in whole ion focusing transmission lens, thus enter by the gaseous ion carrier band of resolving the determinand produced in ion focusing transmission lens, and combine with the electric field axially converged in transmission lens, make gaseous ion produce focusing effect, more efficientlyly transfer to mass analyzer, reduce the loss of ion in transmitting procedure.
Summary of the invention
The object of the present invention is to provide a kind of for the ion focusing transmission lens under the atmospheric pressure of mass spectral analysis, make to ionize by atmospheric pressure ionization source the ion produced, effectively converged after by this ion focusing transmission lens, thus in mass spectral analysis afterwards detects, strengthen sensitivity and the measuring accuracy of mass analyzer.
For achieving the above object, the technical solution used in the present invention is:
An ion focusing transmission lens under atmospheric pressure, comprises stainless steel electrode ring, and dielectric ring and stainless steel urceolus, is characterized in that:
Stainless steel urceolus is airtight tubular structure, in about stainless steel urceolus, two end faces is respectively arranged with ion entrance and ion outlet;
Stainless steel electrode ring and dielectric ring are circulus, are respectively more than 2 or 3;
Stainless steel electrode ring and dielectric ring spaced, coaxial, be set in parallel in stainless steel outer barrel near ion entrance one end;
Ion entrance, stainless steel electrode ring and ion outlet are parallel to each other, coaxially arrange;
Gas vent is provided with on the sidewall of the stainless steel urceolus near ion outlet place;
Gas vent is connected with aspiration pump by pipeline.
Gas vent is taken out valve by vacuum line and side and is connected, and the other end taking out valve in side is connected with aspiration pump by vacuum line.
The vacuum valve that valve is regulating flow quantity is taken out in described side, is vacuum flapper valve, vacuum butterfly valve or vacuum needle-valve.
One mass spectrum sample feeding pipe extend into stainless steel outer barrel through ion outlet, and the entrance of mass spectrum sample feeding pipe is arranged at stainless steel electrode Ring current distribution axis place;
, ion entrance front end outside in stainless steel urceolus is provided with sample carrying platform and atmospheric pressure ionization source, and the gaseous ion of generation to the entrance of mass spectrum sample feeding pipe through stainless steel electrode ring and dielectric Ring current distribution area transmissions, enters in mass analyzer and detects.
Described mass analyzer is time of flight mass analyzer, level Four bar mass analyzer, ion strap mass analyzer or ion cyclotron resonance mass analyzer;
The internal diameter of dielectric ring is greater than the internal diameter of stainless steel electrode ring.
The voltage of different amplitude is loaded successively on each stainless steel electrode ring, along ion entrance on the axis direction of ion outlet, the voltage of adjacent stainless steel electrode interannular increases progressively gradually, and the increasing proportion of voltage difference is 1:1 ~ 1:100 between adjacent stainless steel electrode ring, form the electric field that field intensity strengthens gradually.
Insulating medium layer is provided with between stainless steel electrode ring and stainless steel urceolus.
Ion focusing transmission lens provided by the invention, the laminar flow that the electric field formed by regulating electrode retaining collar and aspiration pump are formed, and then realize the focusing for gaseous ion.Specifically, the gaseous ion carrier band of resolving the determinand produced enters in ion focusing transmission lens by laminar gas, and guides gaseous ion to move to the direction of mass analyzer.And the voltage be carried on electrode retaining collar, act on the gaseous ion by ion focusing lenses, it is made to converge to axis, thus decrease gaseous ion to greatest extent owing to dispersing the loss brought, make more gaseous ion enter into mass analyzer, thus improve sensitivity and the measuring accuracy of mass analyzer.
Accompanying drawing explanation
Fig. 1 is the structural representation of ion focusing transmission lens device of the present invention.
Fig. 2 is the electric field of adjacent stainless steel electrode loop voltag difference ratio when being 1:1 and ion transfer trace simulation figure.
Fig. 3 is the electric field of adjacent stainless steel electrode loop voltag difference ratio when being 1:3 and ion transfer trace simulation figure.
Embodiment
Referring to Fig. 1, is structural representation of the present invention, and in figure, 3 is mass analyzer, and 6 is gaseous ion, and 10 is sample carrying platform, and 11 is atmospheric pressure ionization source, and 12 is testing sample.Ion focusing transmission lens of the present invention, is made up of dielectric ring 1, stainless steel metal urceolus 2, stainless steel electrode ring 9.
Stainless steel urceolus 2 is airtight tubular structure, on stainless steel urceolus about 2 two end faces, be respectively arranged with ion entrance 13 and ion outlet 4;
Stainless steel electrode ring 9 and dielectric ring 1 are circulus, are respectively more than 2 or 3;
Stainless steel electrode ring 9 and dielectric ring 1 stainless steel urceolus 2 that is spaced, coaxial, that be set in parallel near ion entrance 13 one end inner;
Ion entrance 13, stainless steel electrode ring 9 and ion outlet 4 are parallel to each other, coaxially arrange, and are provided with dielectric between stainless steel electrode ring 9 and stainless steel urceolus 2;
Gas vent is provided with on the sidewall of the stainless steel urceolus 2 near ion outlet 4 place;
Gas vent is taken out valve 8 by vacuum line and side and is connected, and the other end taking out valve 8 in side is connected with aspiration pump 7 by vacuum line.Valve 8 is taken out by regulating side, control the pumping speed of aspiration pump 7, thus suitable laminar flow is formed in whole ion focusing transmission lens system, to enter in ion focusing system by gaseous ion 6 carrier band of resolving the determinand produced, the transmission of auxiliary gaseous ion 6, guide gaseous ion 6 to arrive mass analyzer 3, thus reduce the loss of gaseous ion 6 in transmitting procedure.
It is inner that one mass spectrum sample feeding pipe 5 extend into stainless steel urceolus 2 through ion outlet 4, and the entrance of mass spectrum sample feeding pipe 5 is arranged at the central axis place of stainless steel electrode ring 9;
, ion entrance 13 front end outside in stainless steel urceolus 2 is provided with sample carrying platform 10 and atmospheric pressure ionization source 11, a large amount of loads that ionization source 11 produces have the fine droplet of energy and electric charge, be ejected on the sample 12 on sample carrying platform 10 surface, the fine droplet of rapid movement produces analytic function to the determinand on sample 12 surface, and the transfer of adjoint electric charge generates the gaseous ion 6 of determinand.The gaseous ion 6 produced transfers to the entrance of mass spectrum sample feeding pipe 5 through the central area of stainless steel electrode ring 9 and dielectric ring 1, enters in mass analyzer 3 and detects.
The thickness of dielectric ring 1 is 2-5mm, and the thickness of stainless steel electrode ring 9 is 10-15mm, and the internal diameter of dielectric ring 1 is greater than the internal diameter of stainless steel electrode ring 9.
The voltage of different amplitude is loaded successively on each stainless steel electrode ring 9, on the axis direction along ion entrance 13 to ion outlet 4, voltage between adjacent stainless steel electrode ring 9 increases progressively gradually, and the increasing proportion of voltage difference is 1:1 ~ 1:100 between adjacent stainless steel electrode ring 9, form the electric field that field intensity strengthens gradually.After the electric field generated makes gaseous ion 6 enter ion focusing transmission lens with laminar flow, converge along its axis direction, thus decrease the loss owing to dispersing the gaseous ion caused.
Fig. 2 and Fig. 3 is the ion of karyoplasmic ratio m/z=100, the SIMION software simulation figure moved in ion focusing transmission lens of the present invention.As shown in the figure, 9 is stainless steel electrode ring, in this simulated experiment, is provided with 9 pieces of stainless steel electrode rings altogether; 5 is mass spectrographic sample feeding pipe.In figure, the curve along X-direction is the movement locus of ion in transmission lens, along the electric field line formed after the curve of Y direction is stainless steel electrode ring on-load voltage.
In fig. 2, the voltage difference of adjacent stainless steel electrode interannular, increases progressively according to the ratio of 1:1, thus in whole ion focusing transmission lens system, define more uniform electric field, under the effect of this electric field, ion, with laminar gas, moves in the X-axis direction, and convergence effect is poor; And in figure 3, the voltage difference of adjacent stainless steel electrode interannular, increases progressively according to the ratio of 1:3, in whole ion focusing transmission lens system, define the electric field that field intensity strengthens gradually, convergence effect is greatly improved.
Claims (8)
1. the ion focusing transmission lens under atmospheric pressure, is characterized in that: comprise stainless steel electrode ring (9), dielectric ring (1) and stainless steel urceolus (2),
Stainless steel urceolus (2) is airtight tubular structure, on two end faces in stainless steel urceolus (2) left and right, be respectively arranged with ion entrance (13) and ion outlet (4);
Stainless steel electrode ring (9) and dielectric ring (1) are circulus, are respectively more than 2 or 3;
Stainless steel electrode ring (9) and dielectric ring (1) stainless steel urceolus (2) that is spaced, coaxial, that be set in parallel near ion entrance (13) one end inner;
Ion entrance (13), stainless steel electrode ring (9) and ion outlet (4) are parallel to each other, coaxially arrange;
Gas vent is provided with on the sidewall of the stainless steel urceolus (2) near ion outlet (4) place;
Gas vent is connected with aspiration pump (7) by pipeline.
2., according to ion focusing transmission lens according to claim 1, it is characterized in that:
Gas vent is taken out valve (8) by vacuum line and side and is connected, and the other end taking out valve (8) in side is connected with aspiration pump (7) by vacuum line.
3., according to ion focusing transmission lens according to claim 1, it is characterized in that:
The vacuum valve that valve (8) is regulating flow quantity is taken out in described side, is vacuum flapper valve, vacuum butterfly valve or vacuum needle-valve.
4., according to ion focusing transmission lens according to claim 1, it is characterized in that:
It is inner that one mass spectrum sample feeding pipe (5) extend into stainless steel urceolus (2) through ion outlet (4), and the entrance of mass spectrum sample feeding pipe (5) is arranged at the central axis place of stainless steel electrode ring (9);
, ion entrance (13) front end outside in stainless steel urceolus (2) is provided with sample carrying platform (10) and atmospheric pressure ionization source (11), the gaseous ion (6) produced transfers to the entrance of mass spectrum sample feeding pipe (5) through the central area of stainless steel electrode ring (9) and dielectric ring (1), enters detection in mass analyzer (3).
5., according to ion focusing transmission lens according to claim 4, it is characterized in that:
Described mass analyzer (3) is time of flight mass analyzer, level Four bar mass analyzer, ion strap mass analyzer or ion cyclotron resonance mass analyzer.
6., according to ion focusing transmission lens according to claim 1, it is characterized in that:
The internal diameter of dielectric ring (1) is greater than the internal diameter of stainless steel electrode ring (9).
7., according to ion focusing transmission lens according to claim 1, it is characterized in that:
The voltage of different amplitude is loaded successively on each stainless steel electrode ring (9), along ion entrance (13) on the axis direction of ion outlet (4), voltage between adjacent stainless steel electrode ring (9) increases progressively gradually, and the increasing proportion of voltage difference is 1:1 ~ 1:100 between adjacent stainless steel electrode ring (9), form the electric field that field intensity strengthens gradually.
8., according to ion focusing transmission lens according to claim 1, it is characterized in that:
Insulating medium layer is provided with between stainless steel electrode ring (9) and stainless steel urceolus (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310272797.6A CN104282525A (en) | 2013-07-01 | 2013-07-01 | Ion focusing transmission lens under atmosphere pressure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310272797.6A CN104282525A (en) | 2013-07-01 | 2013-07-01 | Ion focusing transmission lens under atmosphere pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104282525A true CN104282525A (en) | 2015-01-14 |
Family
ID=52257312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310272797.6A Pending CN104282525A (en) | 2013-07-01 | 2013-07-01 | Ion focusing transmission lens under atmosphere pressure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104282525A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108091537A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of ladder Field ion mobility pipe |
| CN110828281A (en) * | 2019-11-15 | 2020-02-21 | 中国科学院大连化学物理研究所 | Ion enrichment ion migration tube |
| CN111613514A (en) * | 2020-06-24 | 2020-09-01 | 成都艾立本科技有限公司 | High-sensitivity ultraviolet light ionization time-of-flight mass spectrometer and ion time-of-flight measuring method |
| CN112420481A (en) * | 2020-11-26 | 2021-02-26 | 中国科学技术大学 | Mass spectrometer and ion lens device thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080142705A1 (en) * | 2006-12-13 | 2008-06-19 | Schwartz Jae C | Differential-pressure dual ion trap mass analyzer and methods of use thereof |
| CN102232238A (en) * | 2008-10-13 | 2011-11-02 | 普度研究基金会 | Systems and methods for transfer of ions for analysis |
| CN102280346A (en) * | 2010-06-08 | 2011-12-14 | 江苏天瑞仪器股份有限公司 | Ion extraction lens for mass spectrometer |
| CN102449727A (en) * | 2009-05-01 | 2012-05-09 | 株式会社岛津制作所 | Ion analysis apparatus for conducting differential ion mobility analysis and mass analysis and the method of use |
| CN102479662A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Vacuum ultraviolet light ionization source used for high-flux gas sample analysis |
| CN102768936A (en) * | 2006-11-07 | 2012-11-07 | 塞莫费雪科学（不来梅）有限公司 | Ion transfer arrangement |
| CN103165390A (en) * | 2011-12-19 | 2013-06-19 | 中国科学院大连化学物理研究所 | Ozone modified beta radioactive ion source and application thereof |
-
2013
- 2013-07-01 CN CN201310272797.6A patent/CN104282525A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102768936A (en) * | 2006-11-07 | 2012-11-07 | 塞莫费雪科学（不来梅）有限公司 | Ion transfer arrangement |
| US20080142705A1 (en) * | 2006-12-13 | 2008-06-19 | Schwartz Jae C | Differential-pressure dual ion trap mass analyzer and methods of use thereof |
| CN102232238A (en) * | 2008-10-13 | 2011-11-02 | 普度研究基金会 | Systems and methods for transfer of ions for analysis |
| CN102449727A (en) * | 2009-05-01 | 2012-05-09 | 株式会社岛津制作所 | Ion analysis apparatus for conducting differential ion mobility analysis and mass analysis and the method of use |
| CN102280346A (en) * | 2010-06-08 | 2011-12-14 | 江苏天瑞仪器股份有限公司 | Ion extraction lens for mass spectrometer |
| CN102479662A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Vacuum ultraviolet light ionization source used for high-flux gas sample analysis |
| CN103165390A (en) * | 2011-12-19 | 2013-06-19 | 中国科学院大连化学物理研究所 | Ozone modified beta radioactive ion source and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| R. GRAHAM COOKS ET AL: "Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization", 《SCIENCE》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108091537A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of ladder Field ion mobility pipe |
| CN110828281A (en) * | 2019-11-15 | 2020-02-21 | 中国科学院大连化学物理研究所 | Ion enrichment ion migration tube |
| CN111613514A (en) * | 2020-06-24 | 2020-09-01 | 成都艾立本科技有限公司 | High-sensitivity ultraviolet light ionization time-of-flight mass spectrometer and ion time-of-flight measuring method |
| CN111613514B (en) * | 2020-06-24 | 2023-11-03 | 成都艾立本科技有限公司 | High-sensitivity ultraviolet ionization time-of-flight mass spectrometer and ion time-of-flight measurement method |
| CN112420481A (en) * | 2020-11-26 | 2021-02-26 | 中国科学技术大学 | Mass spectrometer and ion lens device thereof |
| CN112420481B (en) * | 2020-11-26 | 2022-04-19 | 中国科学技术大学 | Mass spectrometer and ion lens device thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7078679B2 (en) | Inductive detection for mass spectrometry | |
| US9576781B2 (en) | Intelligent dynamic range enhancement | |
| CN104576287B (en) | Ion source system and mass spectrometer for atmospheric pressure interface | |
| CN103065921A (en) | Multiple-reflection high resolution time-of-flight mass spectrometer | |
| SG192703A1 (en) | Methods, apparatus, and system for mass spectrometry | |
| CN104966660B (en) | A kind of proton translocation mass spectrograph and its application method | |
| CN104241077B (en) | Normal pressure micro-glow discharge maldi mass spectrometer ion gun of magnetically confined and mass spectrometer | |
| CN101789355A (en) | Time-of-flight mass spectrometer with wide dynamic range, implementation method and application thereof | |
| CN104282525A (en) | Ion focusing transmission lens under atmosphere pressure | |
| CN105300855A (en) | Method for detecting solid material sample elementary composition on line in real time | |
| CN105301088A (en) | Accelerator mass spectrometer with simultaneous isotope measurement function | |
| GB2541384A (en) | Collision cell having an axial field | |
| CN203367224U (en) | Normal pressure direct ionization mass spectrum device of concealed ion source | |
| CN103295872A (en) | Compound ion source device and mass spectrometer | |
| CN102290319B (en) | Dual-ion trap mass spectrometer | |
| CN106596703A (en) | Method for quickly detecting fatty acid in rice through internal extraction electrospray ionization-mass spectrometry | |
| CN107946167B (en) | A kind of metal complex mass spectrometer | |
| CN207719138U (en) | A kind of portable mass spectrometer | |
| Li et al. | New strategy for further improving the detection sensitivity of direct analysis in real time-mass spectrometry | |
| CN107706081B (en) | The application method of mass spectrometer system, chromatography-mass spectroscopy system and the two | |
| CN213364647U (en) | Time-of-flight mass spectrometry equipment for high-resolution and high-sensitivity determination of VOCs content | |
| CN108074793B (en) | A kind of multi-mode mass spectrum ionization source of multicomponent sample analysis | |
| CN105632875B (en) | Desorption ionization mass spectrometer interface for mass spectrographic imaging | |
| CN202454525U (en) | Compound ion source device and mass spectrometer | |
| CN210200666U (en) | Mass spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150114 |