CN106053832A - 评估造血毒性的工具和方法 - Google Patents

评估造血毒性的工具和方法 Download PDF

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Publication number
CN106053832A
CN106053832A CN201610422742.2A CN201610422742A CN106053832A CN 106053832 A CN106053832 A CN 106053832A CN 201610422742 A CN201610422742 A CN 201610422742A CN 106053832 A CN106053832 A CN 106053832A
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CN
China
Prior art keywords
biomarker
hematopoietic toxicity
subject
subjects
dinitrobenzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610422742.2A
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English (en)
Chinese (zh)
Inventor
T·B·沃克
B·范拉文兹韦
W·梅勒特
E·法比安
V·施特劳斯
H·坎普
J·C·维默尔
R·洛塞
M·M·赫罗尔德
A·普奥考汀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of CN106053832A publication Critical patent/CN106053832A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/709—Toxin induced

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201610422742.2A 2011-09-13 2012-09-12 评估造血毒性的工具和方法 Pending CN106053832A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161533867P 2011-09-13 2011-09-13
EP11181156 2011-09-13
US61/533,867 2011-09-13
EP11181156.8 2011-09-13
CN201280044690.XA CN103827667B (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280044690.XA Division CN103827667B (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

Publications (1)

Publication Number Publication Date
CN106053832A true CN106053832A (zh) 2016-10-26

Family

ID=47882692

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610422742.2A Pending CN106053832A (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法
CN201280044690.XA Expired - Fee Related CN103827667B (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280044690.XA Expired - Fee Related CN103827667B (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

Country Status (10)

Country Link
US (1) US20150037825A1 (https=)
EP (1) EP2756301A4 (https=)
JP (1) JP2014526681A (https=)
KR (1) KR20140059805A (https=)
CN (2) CN106053832A (https=)
AU (1) AU2012310147A1 (https=)
BR (1) BR112014005472A2 (https=)
CA (1) CA2845621A1 (https=)
IL (1) IL231007A0 (https=)
WO (1) WO2013038341A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114594192A (zh) * 2022-03-07 2022-06-07 山东大学 一种泊沙康唑起始物料中氯苯胺和氯硝基苯胺同分异构体的检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080311586A1 (en) * 2007-06-13 2008-12-18 Litron Laboratories, Ltd. Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment
CN101529249A (zh) * 2006-08-30 2009-09-09 梅坦诺米克斯有限公司 用于诊断溶血性贫血的工具和方法
CN102105792A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112409B2 (en) * 1999-01-29 2006-09-26 Center For Molecular Medicine And Immunology Method of determining cytokine dosage for myelosuppressive state
JP2003245076A (ja) * 2001-01-30 2003-09-02 Takeda Chem Ind Ltd 新規タンパク質およびそのｄｎａ
AU2003258319B2 (en) * 2002-08-21 2009-09-17 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
US20040121305A1 (en) * 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US8034613B2 (en) * 2005-06-01 2011-10-11 Wisconsin Alumni Research Foundation Multipotent lymphohematopoietic progenitor cells
US7689187B2 (en) * 2007-03-01 2010-03-30 Motorola, Inc. Dual input low noise amplifier for multi-band operation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101529249A (zh) * 2006-08-30 2009-09-09 梅坦诺米克斯有限公司 用于诊断溶血性贫血的工具和方法
US20080311586A1 (en) * 2007-06-13 2008-12-18 Litron Laboratories, Ltd. Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment
CN102105792A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法

Also Published As

Publication number Publication date
US20150037825A1 (en) 2015-02-05
IL231007A0 (en) 2014-03-31
CN103827667B (zh) 2016-07-13
EP2756301A4 (en) 2015-08-12
CN103827667A (zh) 2014-05-28
WO2013038341A1 (en) 2013-03-21
CA2845621A1 (en) 2013-03-21
KR20140059805A (ko) 2014-05-16
BR112014005472A2 (pt) 2017-03-28
EP2756301A1 (en) 2014-07-23
AU2012310147A1 (en) 2014-03-13
JP2014526681A (ja) 2014-10-06

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Application publication date: 20161026

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