CN106039230A - Traditional Chinese medicinal composition for treating hyperplasia of mammary glands and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating hyperplasia of mammary glands and preparation method of traditional Chinese medicinal composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a traditional Chinese medicinal composition for treating hyperplasia of mammary glands and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition comprises five-leaf akebia fruits, agapetes, diospyros cathayensis, ilex rotunda thumb, motherwort fruits, air potatoes, rhizoma sparganii, semen oroxyli, radix curcumae, halenia elliptica and the like. The traditional Chinese medicinal composition is mainly used for treating the hyperplasia of the mammary glands.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating cyclomastopathy and preparation side thereof
Method.
Background technology
Cyclomastopathy is the benign proliferative diseases of the most non-the most noninflammatory tumor in mammary gland tissue.With mastalgia,
Lump or companion's discharge are the disease of principal character.It is apt to occur in 25 45 years old women, pain occurs with unilateral or bilateral breast and goes out
Existing lump, mastalgia and lump change closely related with menstrual cycle and feelings will.
Its etiology and pathogenesis is actually: feelings will is unsuccessful, depression of liver-QI, depression and stagnation of QI, pents up in breast stomach network, and breast network blocks not
Logical, stagnation of QI and blood may bring about pain.Edema with the liver involved gram spleen soil, insufficiency of the spleen expectorant coagulates, the long heat-transformation of hepatic depression in addition, and the bright cloudy liquid of heat, the expectorant blood coagulation stasis of blood forms caking.
Nodules of the breast is equivalent to cyclomastopathy and mammary gland fibroma etc. in doctor trained in Western medicine.The Syndrome Types of TCM of nodules of the breast is a lot of, but the most not
Outer stagnation of QI due to depression of the liver, stagnation of QI expectorant are solidifying, blood stasis expectorant is solidifying, discord, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, QI and blood deficiency etc. are appointed in punching.Each family
Though suggestion is not the same, but its pathogenesis all be unable to do without above-mentioned viewpoint.Common clinical syndrome differentiation is divided into four types to carry out by controlling.
Stagnation of QI due to depression of the liver: stagnation of liver-QI is not relaxed, breast distension, caking distending pain with susceptible to anger growth and decline, time have twinge, two side of body distending pains, bitter taste
Agitation, pale tongue with thin fur is white, stringy pulse or thin string.
Blood stasis due to renal deficiency: with the passing of time breast lumps, twinge or have a dull ache, and sore spot is fixed.Companion's soreness of waist is weak, the color through water is few
Light, or amenorrhea, the disease such as infertile.Tongue is dark or there are petechia, white and thin fur, deep-thready pulse in tongue limit.
Insufficiency of the spleen expectorant coagulates: lump in breast is relatively big, but poor growth, matter heavily fortified point distending pain, smooth surface, push away can move, clear border,
Mammary contour is constant.Thin white fur of tongue, stringy and rolling pulse.
Chong and Ren channel disorder: breast lumps, dull pain or twinge, localized pain.Premenstrual lump significantly increases, through after reduce deliquescing,
Or companion's menoxenia, dysmenorrhea, the disease such as infertile.Light red tongue tongue is white, and thready pulse moistens.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating cyclomastopathy；
It is a further object of the present invention to provide the preparation method of a kind of Chinese medicine composition treating cyclomastopathy.
It is an object of the invention to by following technical scheme realization:
The Chinese medicine composition for the treatment of cyclomastopathy of the present invention, is to be prepared from by the raw material of Chinese medicine of following weight portion
:
Fructus Akebiae 20-40 part, Agapetes neriifolia (King et Prain) Airv-Shaw 10-30 part, monkey door 8-25 part, Cortex Ilicis Rotundae 20-40 part, Fructus Leonuri 10-30 part, xanthate
Sub-10-30 part, Rhizoma Sparganii 8-25 part, Semen Oroxyli 10-30 part, Radix Curcumae 8-25 part, Radix haleniae ellipticae 10-30 part.Preferably, it is by weighing as follows
The raw material of Chinese medicine of amount part is prepared from:
Fructus Akebiae 25-35 part, Agapetes neriifolia (King et Prain) Airv-Shaw 15-25 part, monkey door 10-20 part, Cortex Ilicis Rotundae 25-35 part, Fructus Leonuri 15-25 part, xanthate
Sub-15-25 part, Rhizoma Sparganii 10-20 part, Semen Oroxyli 15-25 part, Radix Curcumae 10-20 part, Radix haleniae ellipticae 15-25 part.
The following is the crude drug source of Chinese medicine preparation of the present invention:
Fructus Akebiae, for BENTONG section plant Caulis Akebiae, threeleaf akebia, the fruit of white BENTONG.[nature and flavor] are sweet, cold.[function cures mainly] soothing liver-QI
Regulate the flow of vital energy, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp,
Uterus drops.
Agapetes neriifolia (King et Prain) Airv-Shaw, Ericaceae likes Phoebe plant styrax tonkinensis Craib ex Hart Radix Raphani Agapetes mannii Hemsl. [A.
Yunnanensis Franch.], it is used as medicine with root.[nature and flavor] are puckery, light, cool.[function cures mainly] eliminating stasis to stop pain, inducing diuresis to remove edema.For
Traumatic injury, rheumatalgia, stomachache, hepatitis, edema, innominate toxic swelling.Traumatic hemorrhage is controlled in external.
Monkey door, for the fruit of Ebenaceae plant Foochow Fructus Kaki.[nature and flavor] are bitter；Warm in nature.[function cures mainly] Yishen Jianpi.Master suffers from a deficiency of the kidney
Spleen is weak；Lassitude and weak.
Cortex Ilicis Rotundae, the bark (double-layer fur) of Aquifoliaceae Holly Ilex rotunda Thunb. Ilex rotunda Thunb., leaf, root
Also can be used as medicine.[nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For catching a cold, tonsillitis, laryngopharynx swelling and pain,
Acute gastroenteritis, rheumatic ostalgia；Traumatic injury, carbuncle furuncle infections, traumatic hemorrhage, burn and scald are controlled in external.
Fructus Leonuri, for the dry mature fruit of labiate Herba Leonuri Leonurus japonicus Houtt..[property
Taste] pungent, bitter, it is slightly cold.[return through] GUIXIN bag, Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.For menoxenia, warp
Close, dysmenorrhea, cataract, dizzy distending pain.
Rhizoma Dioscoreae Bulbiferae, Dioscoreaceae yam Dioscorea bulbifera L. Dioscorea bulbifera L., tuber.[nature and flavor] are bitter, pungent,
Cool.Slightly poisonous.[function cures mainly] removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, cooling blood for hemostasis.For thyromegaly, tuberculous lymphadenitis, throat
Swell and ache, spit blood, spitting of blood, pertussis, cancerous protuberance；Furuncle is controlled in external.
Rhizoma Sparganii, for the dried pieces of Sparganiaceae plant rhizoma scirpi Sparganium stoloniferum Buch.-Ham.
Stem.[nature and flavor] are pungent, bitter, flat.[return through] returns liver, spleen channel.[function cures mainly] removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, the stasis of blood
Blood amenorrhea, food stagnation distending pain.
Semen Oroxyli, the dry mature seed of Bignoniaceae plant oroxylum indicum Oroxylum indicum (L.) Vent..[property
Taste] bitter, sweet, cool.[return through] returns lung, liver, stomach warp.[function cures mainly] removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat,
Hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Radix Curcumae, for zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae
Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or fluffy cowherb
The dried root of art Curcuma phaeocaulis Val..[nature and flavor] are pungent, bitter, cold.[return through] returns liver, the heart, lung meridian.[function
Cure mainly] regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy goes mad,
Jaundice dark coloured urine.
Radix haleniae ellipticae, Gentianaceae Herba Haleniae Corniculatae platymiscium purple is spent anchor Halenia elliptica D. Don in vain, is entered with root or herb
Medicine.[nature and flavor] are bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, suppressing the hyperactive liver function of gallbladder promoting.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is
Use water to carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.Concrete preparation method is as follows:
Scheme one: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight,
Extraction time is 1-3 hour every time, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20
Clear paste, obtain active component.
Scheme two: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material total amount
4-10 times, extraction time is 1-4 hour, united extraction liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is
1.15-1.20 clear paste, obtain active component.
Scheme three: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-of medical material gross weight
12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
The clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80
DEG C time relative density be the extractum of 1.10-1.25, obtain active component.
The Chinese medicine composition for the treatment of cyclomastopathy of the present invention, it is also possible to pharmaceutically acceptable carrier
Coordinate, make various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture etc..
The pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc..
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc..
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc..
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, vegetable oil etc..
Correctives: sucrose, monosaccharide, aromatic etc..
Preservative: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc..
Method 1: tablet
Taking one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into this routinely
Invention tablet.
Above-mentioned tablet is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Taking one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into routinely
Capsule of the present invention.
Above-mentioned capsule is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Taking one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into routinely
Syrup of the present invention.
Above-mentioned syrup is commonly used adjuvant and is included one of correctives, preservative, cosolvent or whole.
Method 4: mixture
Taking one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into this routinely
Invention mixture.
Above-mentioned mixture is commonly used adjuvant and is included one of correctives, preservative or whole.
Method 5: oral liquid
Take one of scheme one to scheme three gained active component, dissolve after-purification, concentration, add oral liquid and commonly use adjuvant, by often
Rule production method is prepared into oral liquid of the present invention.
The applicant is extensively reading document at all times, uses Traditional Chinese medical theory, in conjunction with modern diagnosis and treatment experience, finds one
The Chinese medicine composition for the treatment of cyclomastopathy disease.Fructus Akebiae depressed liver-energy dispersing and QI regulating, Cortex Ilicis Rotundae clearing heat for detumescence in side, for Fang Zhongjun
Medicine；Agapetes neriifolia (King et Prain) Airv-Shaw, Fructus Leonuri, Rhizoma Dioscoreae Bulbiferae, Semen Oroxyli, Radix haleniae ellipticae is soothing the liver detumescence, heat clearing and blood circulation promoting and be minister；Monkey door, Rhizoma Sparganii, Radix Curcumae
Removing food stagnancy resolving depression, Yishen Jianpi and be assistant.Taking a broad view of full side, full side cooperates, and has depressed liver-energy dispersing and QI regulating, resolving depression detumescence, heat clearing and blood circulation promoting,
Effect.Treatment for cyclomastopathy.
A kind of Chinese medicine composition treating cyclomastopathy that the present invention provides has the advantage that
1, the composite preparation that the present invention provides is safe and effective, has depressed liver-energy dispersing and QI regulating, resolving depression detumescence, heat clearing and blood circulation promoting, effect.
Treatment for cyclomastopathy.2, clinical tests prove that, by the present invention to cyclomastopathy patient treatment after, have
Efficiency reaches 97.44%, shows that the present invention can effectively treat cyclomastopathy.
3, the Chinese medicinal composition preparation that the present invention provides, scientific formulation is reasonable, and technique is simple, in good taste, low cost.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating
The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention
Claimed scope.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
Embodiment 1 granule
Weigh Fructus Akebiae 20g, Agapetes neriifolia (King et Prain) Airv-Shaw 10g, monkey door 8g, Cortex Ilicis Rotundae 20g, Fructus Leonuri 10g, Rhizoma Dioscoreae Bulbiferae 10g, Rhizoma Sparganii 8g, wood butterfly
Butterfly 10g, Radix Curcumae 8g, Radix haleniae ellipticae 10g.Extracting in water 3 times, three times amount of water is respectively 12 times of medical material gross weight, 8 times, 6 times,
Three extraction times are respectively 3 hours, 2 hours, 1 hour, united extraction liquid, filter, relative density when filtrate is concentrated into 70 DEG C
It is the clear paste of 1.25, adds starch, dextrin, pelletize, be dried, granulate and get final product.
Embodiment 2 tablet
Weigh Fructus Akebiae 40g, Agapetes neriifolia (King et Prain) Airv-Shaw 30g, monkey door 25g, Cortex Ilicis Rotundae 40g, Fructus Leonuri 30g, Rhizoma Dioscoreae Bulbiferae 30g, Rhizoma Sparganii 25g, wood
Butterfly 30g, Radix Curcumae 25g, Radix haleniae ellipticae 30g.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each second
Alcohol consumption is respectively 10 times of medical material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, united extraction liquid, filters, filtrate
When being concentrated into 80 DEG C, relative density is the extractum of 1.10, adds supplementary product starch, ethanol, Pulvis Talci, prepares tablet.
Embodiment 3 tablet
Weigh Fructus Akebiae 25g, Agapetes neriifolia (King et Prain) Airv-Shaw 15g, monkey door 10g, Cortex Ilicis Rotundae 25g, Fructus Leonuri 15g, Rhizoma Dioscoreae Bulbiferae 15g, Rhizoma Sparganii 10g, wood
Butterfly 15g, Radix Curcumae 10g, Radix haleniae ellipticae 15g.Extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medical material gross weight, 8
Times, 6 times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filter, filtrate is concentrated into when 70 DEG C relative
Density is the clear paste of 1.20, adds ethanol, and making alcohol content is 40%, stands 24 hours, filters, and filtrate is concentrated into filtrate and is concentrated into
When 70 DEG C, relative density is the extractum of 1.10, adds supplementary product starch, ethanol, Pulvis Talci, prepares tablet.
Embodiment 4 capsule
Weigh Fructus Akebiae 35g, Agapetes neriifolia (King et Prain) Airv-Shaw 25g, monkey door 20g, Cortex Ilicis Rotundae 35g, Fructus Leonuri 25g, Rhizoma Dioscoreae Bulbiferae 25g, Rhizoma Sparganii 20g, wood
Butterfly 25g, Radix Curcumae 20g, Radix haleniae ellipticae 25g.With 40% alcohol reflux 3 times, each ethanol consumption is respectively the 10 of medical material total amount
Times, 8 times, 4 times, 3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, filter, filtrate concentrates when 60 DEG C the closeest
Degree is the extractum of 1.25, adds supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method in extractum.
Embodiment 5 granule
Weigh Fructus Akebiae 30g, Agapetes neriifolia (King et Prain) Airv-Shaw 20g, monkey door 15g, Cortex Ilicis Rotundae 30g, Fructus Leonuri 20g, Rhizoma Dioscoreae Bulbiferae 20g, Rhizoma Sparganii 15g, wood
Butterfly 20g, Radix Curcumae 15g, Radix haleniae ellipticae 20g.Extracting in water 2 times, each amount of water be respectively equivalent to 12 times of medical material gross weight, 10
Times, each extraction time is respectively 3 hours, 2 hours, united extraction liquid, filters, and filtrate is concentrated into relative density at 80 DEG C and is
The clear paste of 1.05, adds ethanol, and making alcohol content is 70%, stands 12 hours, filters, and when filtrate is concentrated into 70 DEG C, relative density is
The extractum of 1.25, adds starch, dextrin, pelletizes, is dried, granulate and get final product.
Embodiment 6 syrup
Weigh Fructus Akebiae 23g, Agapetes neriifolia (King et Prain) Airv-Shaw 12g, monkey door 9g, Cortex Ilicis Rotundae 23g, Fructus Leonuri 12g, Rhizoma Dioscoreae Bulbiferae 12g, Rhizoma Sparganii 9g, wood butterfly
Butterfly 12g, Radix Curcumae 9g, Radix haleniae ellipticae 12g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, twice
Extraction time is respectively 2 hours, 1 hour, united extraction liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the leaching of 1.10
Cream.In extractum, addition syrup adjuvant sucrose, sorbic acid, water stir, and prepare syrup.
Embodiment 7 oral liquid
Weigh Fructus Akebiae 28g, Agapetes neriifolia (King et Prain) Airv-Shaw 18g, monkey door 12g, Cortex Ilicis Rotundae 28g, Fructus Leonuri 18g, Rhizoma Dioscoreae Bulbiferae 18g, Rhizoma Sparganii 12g, wood
Butterfly 18g, Radix Curcumae 12g, Radix haleniae ellipticae 18g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, and two
Secondary extraction time is respectively 2 hours, 1 hour, united extraction liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is 1.10
Extractum, in extractum, addition adjuvant mannitol, sorbic acid, water stir, and subpackage prepares oral liquid.
Embodiment 8 mixture
Weigh Fructus Akebiae 32g, Agapetes neriifolia (King et Prain) Airv-Shaw 23g, monkey door 18g, Cortex Ilicis Rotundae 32g, Fructus Leonuri 23g, Rhizoma Dioscoreae Bulbiferae 23g, Rhizoma Sparganii 18g, wood
Butterfly 23g, Radix Curcumae 18g, Radix haleniae ellipticae 23g.Extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medical material gross weight, 8
Times, 6 times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filter, it is medicine that filtrate is concentrated into gross weight
3 times of material gross weight, fill, addition mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, and prepare mixture.
Embodiment 9 powder
Weigh Fructus Akebiae 38g, Agapetes neriifolia (King et Prain) Airv-Shaw 28g, monkey door 23g, Cortex Ilicis Rotundae 38g, Fructus Leonuri 28g, Rhizoma Dioscoreae Bulbiferae 28g, Rhizoma Sparganii 23g, wood
Butterfly 28g, Radix Curcumae 23g, Radix haleniae ellipticae 28g.Pulverize, sieve, to obtain final product.
Clinical trial is summed up
1 physical data
Observe 78 example patients, age 21～45 years old, average 39.4 years old；Course of disease June～5 years, average 3.6 years；Unilateral breast is sent out
Sick 25 examples, bilateral breast is fallen ill 53 examples.
2 diagnostic criterias
Draft with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
1. most have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has the tough hard tubercle of beans size, can have tenderness, lump
Border owes clear, with surrounding tissue adhesion；2. breast can have distending pain, the often growth and decline with susceptible to anger, and Chang Yue is premenstrual to be increased the weight of, after menstruation
Alleviate；3. primary disease is more common in 20～40 years old women；4. molybdenum palladium x-ray breast take the photograph sheet, mammary gland noctovisor scan, color doppler sonography surpass
Sound etc. check and help diagnosis, make histopathological examination if desired.
3 Therapeutic Method
Giving the Drug therapy of the embodiment of the present invention 5, oral, 3 times on the one, each 10g, 3 months was 1 course for the treatment of.
4 efficacy evaluations
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Cure: lump in breast and pain disappear, and within after drug withdrawal 3 months, do not recur.
Effective: lump in breast reduces more than 1/2, pain disappears.
Effective: lump in breast reduces less than 1/2, pain relief.
Invalid: lump in breast and pain is unchanged or simple mastalgia is alleviated.
5 results
Table 1 efficacy result
| Recovery from illness | Effective | Effectively | Invalid | (%) | |
| Curative effect | 21 | 46 | 9 | 2 | 97.44 |
Clinical effectiveness shows: by the present invention to cyclomastopathy patient treatment after, effective percentage reaches 97.44%, shows energy of the present invention
Effectively treat cyclomastopathy.
Model case
1, stone, female, 38 years old.Telling bilateral mastalgia, distension, pain lasts does not subtract about 2 years, and breast mass pain is in having after row
Softened, but size is without significant change.The colored ultrasonic prompting of B type: the mammary gland outer upper limit in left side is shown in the agglomerate of 3.2cm × 2.8cm
Shadow, the outer upper limit of right side breast is shown in the agglomerate shadow of 2.5cm × 3.5cm, it is considered to for cyclomastopathy.Give and the embodiment of the present invention
Further consultation after 2 treatments 2 months, tells bilateral mastalgia and substantially alleviates, and lower abdominal pain disappears, slightly dark through row color, blood stasis block is obvious
Reduce, refreshing tired alleviation.Continual cure February, then check color doppler ultrasonography prompting: bilateral breast normal development.The state of an illness is able to
Rehabilitation.
2, beam, female, 42 years old. the right mastalgia of private prosecution 4 years, increases the weight of 3 months, premenstrual, menstrual period or angry postemphasis, warp
Water has held clot under the arm, and under blood stasis, rear all cards alleviate.Over nearly 3 months, exacerbation of symptoms, right breast is persistence distending pain, and paroxysmal is stung
Bitterly.See when examining that patient is in a very depressed state, in right breast, touch streak lump, volume about 5.0cm × 4.5 cm × 3.0cm, matter
Partially hard, smooth surface, obscure boundary, dimly red tongue, white and greasy fur, stringy and rolling pulse.Examine as nodules of the breast.Controlled with the embodiment of the present invention 7
Treating January, patient's readme has no adverse reaction after taking medicine, and right distending pain of the breast substantially alleviates, lump deliquescing.Following the service January, right lump in breast
Disappear, in high spirits, follow up a case by regular visits to have no recurrence after 1 year.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching
Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (7)
1. the Chinese medicine composition treating cyclomastopathy, it is characterised in that it is by the raw material of Chinese medicine system of following weight portion
Standby:
Fructus Akebiae 20-40 part, Agapetes neriifolia (King et Prain) Airv-Shaw 10-30 part, monkey door 8-25 part, Cortex Ilicis Rotundae 20-40 part, Fructus Leonuri 10-30 part, xanthate
Sub-10-30 part, Rhizoma Sparganii 8-25 part, Semen Oroxyli 10-30 part, Radix Curcumae 8-25 part, Radix haleniae ellipticae 10-30 part.
2. the Chinese medicine composition treating cyclomastopathy as claimed in claim 1, it is characterised in that it is as follows by including
The raw material of Chinese medicine of weight portion is prepared from: Fructus Akebiae 25-35 part, Agapetes neriifolia (King et Prain) Airv-Shaw 15-25 part, monkey door 10-20 part, Cortex Ilicis Rotundae 25-
35 parts, Fructus Leonuri 15-25 part, Rhizoma Dioscoreae Bulbiferae 15-25 part, Rhizoma Sparganii 10-20 part, Semen Oroxyli 15-25 part, Radix Curcumae 10-20 part, Radix haleniae ellipticae
15-25 part.
3. the Chinese medicine composition treating cyclomastopathy as claimed in claim 1 or 2, it is characterised in that its active component
It is that employing water carries or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.
4. the Chinese medicine composition treating cyclomastopathy as claimed in claim 3, it is characterised in that its active component is
Being prepared by the following method: take whole medical material, extracting in water 2-3 time after mixing, it is total that each amount of water is equivalent to medical material
6-12 times of weight, each extraction time is 1-3 hour, united extraction liquid, filters, and filtrate is concentrated into when 70-80 DEG C the closeest
Degree is the clear paste of 1.15-1.20, obtains active component.
5. the Chinese medicine composition treating cyclomastopathy as claimed in claim 3, it is characterised in that its active component is
Being prepared by the following method: take whole medical material, use 40-80% alcohol reflux 2-3 time after mixing, each ethanol is used
Amount is 4-10 times of medical material total amount, and extraction time is 1-4 hour, united extraction liquid, filters, and filtrate is concentrated into 70-80 DEG C of phase
It is the clear paste of 1.15-1.20 to density, obtains active component.
6. the Chinese medicine composition treating cyclomastopathy as claimed in claim 3, it is characterised in that its active component is
Being prepared by the following method: take whole medical material, extracting in water 2-3 time after mixing, it is total that each amount of water is equivalent to medical material
6-12 times of weight, each extraction time is 1-3 hour, united extraction liquid, filters, and filtrate is concentrated into when 70-80 DEG C the closeest
Degree is the clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into
When 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
7. treat a preparation for cyclomastopathy, by the Chinese drug-treated group of the treatment cyclomastopathy described in claim 1-6
Compound is prepared from pharmaceutically acceptable carrier combination.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111437303A (en) * | 2020-05-12 | 2020-07-24 | 黄文珍 | Traditional Chinese medicine composition for treating mammary gland lobular hyperplasia and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836722A (en) * | 2005-03-23 | 2006-09-27 | 邢鸿林 | Traditional Chinese medicine for treating gynaecologic disease |
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2016
- 2016-07-27 CN CN201610597640.4A patent/CN106039230A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836722A (en) * | 2005-03-23 | 2006-09-27 | 邢鸿林 | Traditional Chinese medicine for treating gynaecologic disease |
Non-Patent Citations (1)
| Title |
|---|
| 王玉仙: "自拟理气散结汤治疗乳腺增生病178 例", 《中医药临床杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111437303A (en) * | 2020-05-12 | 2020-07-24 | 黄文珍 | Traditional Chinese medicine composition for treating mammary gland lobular hyperplasia and preparation method and application thereof |
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Application publication date: 20161026 |