CN106039196B - 一种治疗高脂血症的药物组合物 - Google Patents
一种治疗高脂血症的药物组合物 Download PDFInfo
- Publication number
- CN106039196B CN106039196B CN201610589923.4A CN201610589923A CN106039196B CN 106039196 B CN106039196 B CN 106039196B CN 201610589923 A CN201610589923 A CN 201610589923A CN 106039196 B CN106039196 B CN 106039196B
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- fructus
- treating
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种治疗高脂血症的药物组合物,其是将包括黄连、猪苓、红花、牛膝、泽泻、丹皮、鬼箭羽、茯苓、桂枝、丹参、山药、葛根、陈皮、砂仁、生薏苡仁、枳壳、补骨脂、荷叶、藿香、佩兰、玉米须、冬瓜皮、蒲黄、炒山楂和鳖甲胶在内的各组分按照一定用量熬制成的膏剂。本发明药物组合物具有多通道多靶点降脂作用,用于调整人体血脂代谢,降低甘油三酯、低密度脂蛋白,提高人体免疫力。本发明药物组合物作用持久、毒副作用小,制备方法可控,适于工业化大生产。
Description
技术领域
本发明属于中药领域,具体涉及一种治疗高脂血症的药物。
背景技术
高脂血症是体内脂质代谢紊乱导致血脂水平增高的一种疾病,其脂质在血管内皮沉积所引起的动脉硬化是高血压病、冠心病、脑梗塞等多种内科疾病的发病诱发。近年来,随着人们生活习惯,特别是饮食习惯的改变等多种因素的影响,高脂血症的发病率有明显增高的趋势,目前,我国约有1.6亿血脂异常患者。
西医治疗高脂血症的方法通常采用口服以降低血清总胆固醇和LDL胆固醇为主的有他汀类和树脂类,以降低血清三酰甘油为主的药物有贝特类和烟酸类。但是,多数降血脂药物有肝功能损害、胃肠道不适、皮肤瘙痒等难以克服的不良反应,还存在停药后血脂容易反弹的弊端。
中医膏方以整体观念和辨证论治体系为指导,并以其毒副作用小、疗效显著、作用持久等优势,克服了以往中药携带不便、服用口感不适等缺点,在现代社会越来越得到了人们的认可和接受,也适应了现代社会注重养生保健的趋势,有广泛的市场和广阔的前景。
发明内容
本发明要解决的技术问题是提供一种治疗高脂血症效果显著的药物组合物及其应用。
为解决上述技术问题,本发明采用的技术方案是:
一种治疗高脂血症的药物组合物,将包括黄连、猪苓、红花、牛膝、泽泻、丹皮、鬼箭羽、茯苓、桂枝、丹参、山药、葛根、陈皮、砂仁、生薏苡仁、枳壳、补骨脂、荷叶、藿香、佩兰、玉米须、冬瓜皮、蒲黄、炒山楂和鳖甲胶在内的各组分按照一定用量熬制成膏剂。
具体的,本发明提供一种治疗高脂血症的药物组合物,将包括以下重量份的中药熬制成膏剂:黄连1-10重量份、猪苓1-20重量份、红花1-10重量份、牛膝1-20重量份、泽泻1-20重量份、丹皮1-20重量份、鬼箭羽1-20重量份、茯苓1-20重量份、桂枝1-20重量份、丹参1-20重量份、山药1-30重量份、葛根1-30重量份、陈皮1-20重量份、砂仁1-10重量份、生薏苡仁1-30重量份、枳壳1-10重量份、补骨脂1-10重量份、荷叶1-10重量份、藿香1-10重量份、佩兰1-10重量份、玉米须1-10重量份、冬瓜皮1-10重量份、蒲黄1-10重量份、炒山楂1-10重量份和鳖甲胶1-30重量份。
优选的,本发明提供一种治疗高脂血症的药物组合物,将包括以下重量份的中药熬制成膏剂:黄连1-5重量份、猪苓2-10重量份、红花1-5重量份、牛膝2-10重量份、泽泻1-8重量份、丹皮3-10重量份、鬼箭羽2-8重量份、茯苓5-15重量份、桂枝3-10重量份、丹参3-10重量份、山药5-15重量份、葛根5-15重量份、陈皮2-8重量份、砂仁2-8重量份、生薏苡仁5-20重量份、枳壳2-8重量份、补骨脂2-8重量份、荷叶2-8重量份、藿香2-8重量份、佩兰2-8重量份、玉米须2-8重量份、冬瓜皮2-8重量份、蒲黄2-8重量份、炒山楂2-8重量份和鳖甲胶3-15重量份。
更优选的,本发明提供一种治疗高脂血症的药物组合物,将包括以下重量份的中药熬制成膏剂:黄连1-3重量份、猪苓3-6重量份、红花1-3重量份、牛膝3-6重量份、泽泻3-6重量份、丹皮3-6重量份、鬼箭羽3-6重量份、茯苓5-10重量份、桂枝3-6重量份、丹参3-6重量份、山药5-10重量份、葛根5-10重量份、陈皮2-6重量份、砂仁2-6重量份、生薏苡仁10-15重量份、枳壳3-6重量份、补骨脂3-6重量份、荷叶3-6重量份、藿香3-6重量份、佩兰3-6重量份、玉米须3-6重量份、冬瓜皮3-6重量份、蒲黄3-6重量份、炒山楂3-6重量份和鳖甲胶5-10重量份。
最优选的,本发明提供一种治疗高脂血症的药物组合物,将包括以下重量份的中药熬制成膏剂:黄连1重量份、猪苓5重量份、红花2重量份、牛膝5重量份、泽泻5重量份、丹皮4重量份、鬼箭羽3重量份、茯苓6重量份、桂枝3重量份、丹参5重量份、山药6重量份、葛根6重量份、陈皮2重量份、砂仁2重量份、生薏苡仁10重量份、枳壳4重量份、补骨脂4重量份、荷叶3重量份、藿香3重量份、佩兰3重量份、玉米须5重量份、冬瓜皮5重量份、蒲黄3重量份、炒山楂5重量份和鳖甲胶8重量份。
优选的,本发明药物组合物加入4-10倍药物重量的水煎煮成膏剂,更优选的,加入6倍药物重量的水。
优选的,本发明药物组合物每次的水煎煮时间为10-60min,更优选的,煎煮时间为30min。
优选的,本发明药物组合物水煎煮次数为2-4次,更优选的,煎煮次数为3次。
其中,黄连:苦,寒。功能主治:清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴。用于湿热内蕴、肠胃湿热、呕吐、泻痢等症。
猪苓:味甘、淡,平。利水渗湿。治小便不利,水肿、泄泻,淋浊,带下。
红花:辛,温。活血通经,去瘀止痛。治经闭,症瘕,难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤。
牛膝:苦、甘、酸,平。逐瘀通经,补肝肾,强筋骨,利尿通淋,引血下行。主治:用于经闭,痛经,腰膝酸痛,筋骨无力,淋证,水肿,头痛,眩晕,牙痛,日疮,吐血,衄血。
泽泻:甘,寒。利水,渗湿,泄热。治小便不利,水肿胀满,呕吐,泻痢,痰饮,脚气,淋病,尿血。补虚损五劳,除五脏痞满,起阴气,止泄精、消渴、淋沥,逐膀胱、三焦停水。
丹皮:寒,味苦;凉;微寒。清热凉血;活血散瘀。温热病热入血分;发斑;吐衄;热泪盈眶病菌后期热伏阴分发热;阴虚骨蒸潮热;血滞经闭;痛经;痈肿疮毒;跌扑伤痛;风湿热痹。
鬼箭羽:苦,寒。行血通经,散瘀止痛。用于经闭,症瘕,产后瘀滞腹痛,虫积腹痛,漆疮。
茯苓:味甘、淡,性平。利水渗湿,健脾,宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
桂枝:性味辛、甘,温。发汗解肌,温经通脉,助阳化气,散寒止痛。主风寒表证;寒湿痹痛;四肢厥冷;经闭痛经;症瘕结块;胸痹;心悸;痰饮;小便不利。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
丹参:味苦,微寒。活血祛瘀,通经止痛,清心除烦,凉血消痈。用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
山药:甘、平、无毒。治诸虚百损、疗五劳七伤、去头面游风、止腰痛、除烦热、补心气不足、开达心孔、多记事、益肾气、健脾胃、止泻痢、润毛皮,生捣贴肿、硬毒能治。
葛根:味甘、辛,性凉。解肌退热,透疹,生津止渴,升阳止泻。用于表证发热,项背强痛,麻疹不透,热病口渴,阴虚消渴,热泻热痢,脾虚泄泻。
陈皮:味苦、辛,性温。理气健脾,燥湿化痰。用于脘腹胀满,食少吐泻,咳嗽痰多。
砂仁:性温,味辛,具有温暖脾肾、下气止痛、宽胸膈、疏气滞、除呕逆、增食欲、止冷泻、开胃、化滞、消食的功效,可有效治疗腹痛胀满、肠鸣泄泻、宿食不化、呕吐清水、舌苔厚腻、孕妇妊娠恶阻反应以及孕妇偶因跌扑,以致胎动不安而腹痛等症。
生薏苡仁:味甘淡。健脾、补肺、清热、利湿的功效。除筋骨邪气不仁,利肠胃,消水肿。治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。
枳壳:性苦、辛、酸、温,具有理气宽中、行滞消胀的功效,主治胸胁气滞,胀满疼痛,食积不化,痰饮内停;胃下垂,脱肛,子官脱垂等病症。
补骨脂:苦、辛、温。补肾壮阳,固精缩尿,肾虚腰痛,小便频数,小儿遗尿,肾漏,温脾止泻,纳气平喘。
荷叶:味苦甘。清心解暑、散瘀止血、消风祛湿。主治暑热烦渴,头痛眩晕,水肿,食少腹胀,泻痢,白带,脱肛,吐血,衄血,咯血,便血,崩漏,产后恶露不净,损伤瘀血。
藿香:辛,微温。芳香化浊,和中止呕,发表解暑。用于湿浊中阻,脘痞呕吐,暑湿表证,湿温初起,发热倦怠,胸闷不舒,寒湿闭暑,腹痛吐泻,鼻渊头痛。
佩兰:感受暑湿;寒热头痛;湿润内蕴;脘痞不饥;恶心呕吐;口中甜腻;消洵。用于湿浊中阻,脘痞呕恶,口中甜腻,口臭,多涎,暑湿表症,头胀胸闷。
玉米须:味甘、淡,性平。利尿消肿;清肝利胆。主水肿,小便淋沥,黄疸,胆囊炎,胆结石,高血压,糖尿病,乳汁不通。
冬瓜皮:味甘,性凉。利尿消肿。用于水肿胀满,小便不利,暑热口渴,小便短赤。
蒲黄:甘,平。止血,化瘀,通淋。用于吐血,衄血,咯血,崩漏,外伤出血,经闭通经,胸腹刺痛,跌扑肿痛,血淋涩痛。
炒山楂:味酸。健脾开胃、消食化滞、活血化痰。主治胸膈脾满、疝气、血淤、闭经等症。
鳖甲胶:味咸;性微寒,补肾滋阴、破瘀散结,有通血脉的作用。
另一方面,本发明还提供上述药物组合物在制备治疗高脂血症药物中的应用。
本发明的有益效果:经过反复多次临床药理研究,本发明的药物组合物被证实具有多通道多靶点降脂作用,对于治疗高脂血症疗效显著。将中药与鳖甲胶制成膏方,不仅服用方便,还加强了药物疗效,调整人体血脂代谢,降低甘油三酯、低密度脂蛋白,提高人体免疫力,并且作用持久、毒副作用小。本发明的膏方制备方法生产条件可控,适用于工业化大规模生产。
具体实施方式
下列实施例中所使用的实验方法如无特殊说明,均为常规方法。
实施例1
取黄连30g、猪苓150g、红花60g、牛膝150g、泽泻150g、丹皮120g、鬼箭羽100g、茯苓200g、桂枝90g、丹参150g、山药200g、葛根200g、陈皮60g、砂仁60g、生薏苡仁300g、枳壳120g、补骨脂120g、荷叶90g、藿香90g、佩兰90g、玉米须150g、冬瓜皮150g、蒲黄100g和炒山楂150g,择净,研细,加入6倍重量的水煎煮30分钟,重复三次,合并滤液,文火浓缩,加入鳖甲胶250g,煮沸收膏,即得。
实施例2
取黄连60g、猪苓300g、红花90g、牛膝210g、泽泻120g、丹皮90g、鬼箭羽60g、茯苓120g、桂枝150g、丹参210g、山药150g、葛根200g、陈皮60g、砂仁60g、生薏苡仁300g、枳壳120g、补骨脂120g、荷叶90g、藿香90g、佩兰90g、玉米须150g、冬瓜皮150g、蒲黄100g和炒山楂150g,择净,研细,加入6倍重量的水煎煮30分钟,重复三次,合并滤液,文火浓缩,加入鳖甲胶300g,煮沸收膏,即得。
实施例3
取黄连60g、猪苓90g、红花30g、牛膝240g、泽泻180g、丹皮180g、鬼箭羽60g、茯苓180g、桂枝60g、丹参60g、山药180g、葛根200g、陈皮60g、砂仁60g、生薏苡仁300g、枳壳120g、补骨脂120g、荷叶90g、藿香90g、佩兰90g、玉米须150g、冬瓜皮150g、蒲黄100g和炒山楂150g,择净,研细,加入6倍重量的水煎煮30分钟,重复三次,合并滤液,文火浓缩,加入鳖甲胶150g,煮沸收膏,即得。
实施例4
取黄连30g、猪苓150g、红花60g、牛膝150g、泽泻150g、丹皮120g、鬼箭羽100g、茯苓200g、桂枝90g、丹参150g、山药200g、葛根150g、陈皮30g、砂仁90g、生薏苡仁180g、枳壳90g、补骨脂90g、荷叶120g、藿香120g、佩兰60g、玉米须180g、冬瓜皮210g、蒲黄60g和炒山楂210g,择净,研细,加入6倍重量的水煎煮30分钟,重复三次,合并滤液,文火浓缩,加入鳖甲胶200g,煮沸收膏,即得。
实施例5
取黄连30g、猪苓150g、红花60g、牛膝150g、泽泻150g、丹皮120g、鬼箭羽100g、茯苓200g、桂枝90g、丹参150g、山药200g、葛根300g、陈皮90g、砂仁90g、生薏苡仁360g、枳壳180g、补骨脂180g、荷叶60g、藿香150g、佩兰150g、玉米须90g、冬瓜皮120g、蒲黄150g和炒山楂90g,择净,研细,加入6倍重量的水煎煮30分钟,重复三次,合并滤液,文火浓缩,加入鳖甲胶300g,煮沸收膏,即得。
试验例1 本发明药物组合物对高脂血症大鼠的试验效果
一、材料与方法
1.动物和造模
选用清洁级雄性SD大鼠若干只,适应性饲养观察1周,根据大鼠的初始体重随机选取10只为基础对照组,饲以普通饲料,其余大鼠饲以高脂饲料,每天12h光照维持,昼夜循环,自由饮水进食。于第6周末夜间禁食12h后眼眶采血检测血脂水平,血脂含量升高并与基础对照组差异显著的大鼠作为成功高脂模型纳入试验。
2.分组给药
选取造模成功的大鼠60只,按血脂水平随机分为高脂对照组和实验组1-5(分别灌胃实施例1-5制备的中药膏剂),每组各10只,另取10只未造模大鼠作为基础对照组。分别取实施例1-5制得的膏剂20g,以纯净水稀释至100ml,再各按照1ml/100g的剂量对实验组1-5中大鼠予以灌胃,基础对照组及高脂对照组均分别灌胃等剂量生理盐水,每天2次,连续15天。灌胃实验期间,除基础对照组外其余各组大鼠均饲以高脂饲料,自由进食、饮水。
3.样品采集与血清生化指标检测
灌胃15天后,大鼠禁食12h,腹主动脉取血,收集血液,离心15min,分离血清,-20℃保存备用。全自动生化分析仪分别检测基础对照组、高脂对照组以及实验组1-5中大鼠血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量,结果如表1所示。
表1 本发明药物组合物对大鼠血脂代谢的影响
由表1可知,与高脂对照组相比,服用本发明实施例1-5膏剂的大鼠血清中TG、TC和LDL-C浓度明显下降,血清中HDL-C浓度显著升高,证实本发明膏剂临床上可以用于治疗高脂血症,其中以实施例1膏剂的降血脂效果最为明显,产生了难以预期的技术效果。
试验例2 本发明药物组合物治疗高脂血症临床效果试验
病历1:李某,女,46岁,浙江杭州人。两年前诊断为高脂血症,肥胖体质,血脂指标:甘油三酯、胆固醇、低密度脂蛋白均明显升高,采用本发明实施例1药膏治疗半年后复查血脂,指标均降至正常水平,体重指数也已达标,查血未见肝肾功能损害,患者自述服药后无明显不适。
病历2:张某,男,55岁,浙江杭州人。2002年诊断为高脂血脂,长期口服他汀类降脂药物控制血脂,血脂控制不佳,并出现肝功能损害、皮疹等服药后不良反应,予以本发明实施例1药膏调理,服用膏方半年后复查血脂均降至正常水平,复查肝肾功能等指标未见异常,患者自述无明显皮疹,无胃肠道不适等不良反应,服药后体重指数降至正常。
Claims (2)
1.一种治疗高脂血症的药物组合物,其特征在于,将以下重量份的中药熬制成膏剂:黄连1重量份、猪苓5重量份、红花2重量份、牛膝5重量份、泽泻5重量份、丹皮4重量份、鬼箭羽3重量份、茯苓6重量份、桂枝3重量份、丹参5重量份、山药6重量份、葛根6重量份、陈皮2重量份、砂仁2重量份、生薏苡仁10重量份、枳壳4重量份、补骨脂4重量份、荷叶3重量份、藿香3重量份、佩兰3重量份、玉米须5重量份、冬瓜皮5重量份、蒲黄3重量份、炒山楂5重量份和鳖甲胶8重量份。
2.权利要求1所述药物组合物在制备治疗高脂血症的药物中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610589923.4A CN106039196B (zh) | 2016-07-21 | 2016-07-21 | 一种治疗高脂血症的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610589923.4A CN106039196B (zh) | 2016-07-21 | 2016-07-21 | 一种治疗高脂血症的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106039196A CN106039196A (zh) | 2016-10-26 |
CN106039196B true CN106039196B (zh) | 2019-12-10 |
Family
ID=57417763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610589923.4A Active CN106039196B (zh) | 2016-07-21 | 2016-07-21 | 一种治疗高脂血症的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106039196B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111903982A (zh) * | 2020-07-16 | 2020-11-10 | 奥克斯路株式会社 | 具有降胆固醇作用的双歧杆菌bz25发酵乳 |
CN115475216B (zh) * | 2022-11-01 | 2023-06-13 | 江苏省中医院 | 一种复方组合药物及其中药制剂和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104587152A (zh) * | 2015-01-22 | 2015-05-06 | 朱黎明 | 治疗中风后遗症、高血压病、高血脂症、高粘血症的中药 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1176135A (zh) * | 1997-10-01 | 1998-03-18 | 叶方荣 | 治疗非甲非乙型肝炎的中药丸剂 |
CN103071108B (zh) * | 2012-12-14 | 2014-02-19 | 史桂群 | 一种治疗脂肪肝的口服药 |
CN103611082A (zh) * | 2013-11-28 | 2014-03-05 | 刘菊 | 一种减肥中药组合物 |
CN104042841A (zh) * | 2014-06-30 | 2014-09-17 | 曹健 | 治疗高血脂的中药制剂 |
CN105250890A (zh) * | 2015-08-28 | 2016-01-20 | 毕国风 | 一种治疗高脂血症中药 |
-
2016
- 2016-07-21 CN CN201610589923.4A patent/CN106039196B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104587152A (zh) * | 2015-01-22 | 2015-05-06 | 朱黎明 | 治疗中风后遗症、高血压病、高血脂症、高粘血症的中药 |
Also Published As
Publication number | Publication date |
---|---|
CN106039196A (zh) | 2016-10-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102048933A (zh) | 一种治疗小儿腹泻的中药组合物及其制备方法 | |
CN104187172B (zh) | 用于治疗乌龟肠胃炎病的功能性饲料及其制备方法 | |
CN103721045B (zh) | 用于提高肉鸡在生长过程中的免疫功能的中药免疫增强剂 | |
CN102772781A (zh) | 一种治疗慢性结肠炎的中药制剂及其制备方法 | |
US10485834B2 (en) | Chinese herbal oral paste for conditioning phlegm-dampness constitution and processing method thereof | |
CN104352920A (zh) | 一种消食和胃的中药组合物 | |
CN101607011B (zh) | 一种治疗胆囊炎术后并发症的中药药物 | |
CN106039196B (zh) | 一种治疗高脂血症的药物组合物 | |
CN105535859A (zh) | 一种用于治疗胃癌的中药制剂及其制备方法 | |
CN100544763C (zh) | 一种治疗冠心病的中药 | |
CN102641463A (zh) | 一种治疗腹泻型肠易激综合征的中药组合物 | |
CN102580048A (zh) | 减肥中药及制备方法 | |
CN105232987A (zh) | 一种促进神经外科术后康复的中药 | |
CN104225200A (zh) | 一种治疗饮凌心肺型心源性哮喘的中药及制备方法 | |
CN103520652B (zh) | 一种治疗肝癌的中药组合物 | |
CN103212030B (zh) | 一种治疗肝郁型乳腺增生的中药及制备方法 | |
CN105233078A (zh) | 一种用于治疗病毒性肝炎的中药组合物 | |
CN104623152A (zh) | 一种治疗痰湿凝聚型甲状腺腺瘤的中药组合物及制备方法 | |
CN104623503A (zh) | 治疗甲状腺机能亢进症的中药剂及制备工艺 | |
CN109078157A (zh) | 一种抗肿瘤药物及其制备方法 | |
CN104491364B (zh) | 一种治疗慢性淋巴细胞性甲状腺炎的药丸及制备方法 | |
CN103735778B (zh) | 一种治疗肥胖症的中药组合物 | |
CN116350731B (zh) | 一种清热除湿通痹方及其制剂和应用 | |
CN105582379A (zh) | 一种治疗肝胃不和的中药组合物及其制备方法 | |
CN101085323A (zh) | 治疗尿毒症的中药组合 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230223 Address after: 321200 No.10, Shangcheng Road, Hushan street, Wuyi County, Jinhua City, Zhejiang Province Patentee after: ZHEJIANG SHOUXIANGU PHARMACEUTICAL Co.,Ltd. Address before: Hangzhou City, Zhejiang province 310013 Xihu District Lingyin Road No. 12 Patentee before: ZHEJIANG Hospital |
|
TR01 | Transfer of patent right |