CN106038904A

CN106038904A - Herba lysimachiae and eulektrol particle composite and preparation method

Info

Publication number: CN106038904A
Application number: CN201610387094.1A
Authority: CN
Inventors: 梁斌; 杨槐; 张丽艳; 唐靖雯; 卢礼平; 彭政忠; 李娇娇
Original assignee: GUIZHOU WARMEN PHARMACEUTICAL CO Ltd
Current assignee: GUIZHOU WARMEN PHARMACEUTICAL CO Ltd
Priority date: 2016-06-03
Filing date: 2016-06-03
Publication date: 2016-10-26
Anticipated expiration: 2036-06-03
Also published as: CN106038904B

Abstract

The invention relates to a herba lysimachiae and eulektrol particle composite and a preparation method, in particular to herba lysimachiae and eulektrol particles. The particle composite is prepared from, by weight, 10-1500 parts of herba glechomae, 10-1000 parts of rhizoma polygoni cuspidati, 10-1000 parts of dandelion, 10-1000 parts of herba artemisiae scopariae, 10-1000 parts of herba lysimachiae, 10-500 parts of salviae miltiorrhizae, 10-500 parts of prepared rhizoma cyperi, 10-500 parts of radix burpleuri, 10-500 parts of fructus mume, 10-500 parts of semen cassiae and a proper quantity of auxiliaries. The invention further relates to the preparation method of the herba lysimachiae and eulektrol particles. The herba lysimachiae and eulektrol particles have excellent properties like excellent stability.

Description

Money DANTONG particulate composition and preparation method

Technical field

The invention belongs to technical field of Chinese medicines, relate to one and treat cholelithiasis medicine money DANTONG particulate composition and system Method, particularly relates to a kind of money DANTONG particulate composition treating cholelithiasis and preparation method thereof.

Background technology

Cholelithiasis is clinical commonly encountered diseases, frequently-occurring disease, and China's sickness rate is more than 10%, and in ascendant trend year by year.Gallbladder The Forming Mechanism of stone disease, is the most not yet fully apparent from, it is considered that with liver and gall infective inflammation, bile component, physics and chemistry Matter is relevant with hydromechanical change.Recent study shows the change of immunoreation, immune complex and some gene expression Also the formation of cholelithiasis may be participated in.Along with going deep into of research, it is believed that cholelithiasis Forming Mechanism will be elucidated with step by step.Clinical On according to calculus distribution of different parts in biliary system, be divided into cholelithiasis and calculus of bile duct (choledocholithiasis regulating liver-QI Interior calculus of bile duct)；According to chemical composition and the mode of appearance of calculus, cholesterol calculus and bile pigment calculus can be divided into again.Now Western medical treatment cholelithiasis is mainly non-operative treatment and operative treatment, and wherein non-operative treatment includes oral cholic acid lithodialysis and rubble Therapy, operative treatment mainly has cholecystectomy, laparoscopic cholecystectomy, Common Bile Duct Exploration And Calculus Extraction, lobe of the liver Excision etc..The effect that the method for the most above-mentioned treatment is reached still clinical patients not is satisfied: although 1. non-operative treatment energy In a short time established for patient calculus is partially or completely dissolved, discharge or take out.But it is little to treat not only success rate, and cost is the biggest (side effect, complication and expensive), and the recurrence of calculus can not be solved at all.In addition the treatment to bilirubinoid calculus There is no preferable scheme at present.Although 2. operative treatment can more thoroughly remove calculus itself and cradle thereof, but the conjunction of operation And disease is the highest, calculus of bile duct especially curative effect of surgical treatment for hepatolithiasis still has higher complication and mortality rate.Additionally, calculus Prolonged stay also can cause canceration, secondary pancreas and liver injury etc. in biliary tract.

Open source literature describes many Herba Lysimachiaes or Herba Lysimachiae mixture treatment urethra and the achievement in research of gallstone disease at present, Such as " Guangxi traditional Chinese medicine " 1990,13 (6) .40-41 " pharmacological research of Herba Lysimachiae granule ", have studied Herba Lysimachiae granule treatment urinary system System calculus and analgesic effect；" journal of shanghai Chinese medicine " 2000,34 (2) .30-31 " Jin qian tong lin Oral Liquid treatment urinary system Togetherness contaminates " for observing Jin qian tong lin Oral Liquid (Herba Lysimachiae, Folium Pyrrosiae, Spora Lygodii, Caulis Lonicerae, Rhizoma Imperatae) treatment urinary system infection The curative effect of lower warmer wetness-heat type stranguria (acute cystitis, acute pyelonephritis, acute episode of chronic pyelonephritis)；Chinese patent Shen Please disclose a kind of medicine treating cholelithiasis by number 200810043138.0 " a kind of pharmaceutical compositions for treating cholelithiasis " Compositions, this medicine is to be prepared from by the Chinese medicine of following weight ratio: 80 parts of Sal Nitri processed, Alumen 35 parts, Radix Curcumae 90 parts, Rhizoma Sparganii 45 Part, Fel Sus domestica unguentum 45 parts, Herba Lysimachiae 225 parts, Pericarpium Citri Reticulatae 150 parts, Olibanum (processed) 35 parts, Myrrha (processed) 35 parts, Radix Et Rhizoma Rhei 45 parts, 25 parts of Radix Glycyrrhizae； Chinese Patent Application No. 200510200576.3 " pharmaceutical preparation for the treatment of cholelithiasis and preparation method thereof " discloses a kind for the treatment of Pharmaceutical preparation of cholelithiasis and preparation method thereof, it selects Herba Lysimachiae 660g, Herba Artemisiae Scopariae 660g, Radix Scutellariae 198g, Radix Aucklandiae 198g, Radix Curcumae 198g, Radix Et Rhizoma Rhei 330g, Semen Arecae 330g, Fructus Aurantii Immaturus (parched with bran) 132g, refining sodium sulphate 66g, refined Cortex Magnoliae Officinalis 132g, make powder.

The traditional Chinese medical science there is no cholelithiasis name of disease, but according to cholelithiasis common sympton, can be belonged to " hypochondriac pain ", " gallbladder-distention ", " stomach The scopes such as gastralgia ", " jaundice ".For its description, can review the earliest and say in "Nei Jing" epoch, such as " Plain Questions Miao stings opinion ": be " evil Visitor, in sufficient collaterals of SHAO YANG, makes us hypochondriac pain being unable to breathe freely ", and for example " Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " is said: " arteries and veins of the few sun of abdominal foot, the diseases resulting from the disorder of this meridian bitter taste, Sighing frequently, it is impossible to change one's position ", " Ling Shu Miraculous Pivot or Divine Axis gallbladder opinion " cloud for another example: " abdominal distention person, distending pain in the hypochondrium, bitter in mouth, sighing frequently ", the most clearly refer to Having gone out the position of disease of cholelithiasis, right liver occupies under the side of body, and its passages through which vital energy circulates cloth two is coerced；The gallbladder being attached to the liver, its arteries and veins also follows between the side of body, liver and gallbladder The exterior and the interior relation is constituted by belonging to through feeling pulse network.The bile that gallbladder is store derives from the residual air of liver, the normal excretion of bile and performance Effect also depends on the catharsis of liver.If the catharsis malfunction of liver, secretion and the excretion of bile will be affected；Otherwise, if Bile excretion is not smooth, also can affect the catharsis of liver.Liver is in gallbladder close ties on physiology and pathology just, has determined liver and gall two Through the common effect in cholelithiasis forming process.As " Jing Yue's complete work hypochondriac pain " piece cloud: " hypochondriac pain originally belong to liver and gall two Warp, all follow side of body rib with the arteries and veins of two warps thus also." cause of disease of cholelithiasis, nothing more than disorder of emotion, eating and drinking without temperance, affection of exogenous damp tripartite The factor in face, long-term feelings will is not relaxed can make stagnation of QI due to depression of the liver, and catharsis is neglected one's duty, and the logical fall of bile is unfavorable.Eating and drinking too much at one meal, irregular diet, throw off restraint Eating pungent, delicious food thickness is greasy, strong tea cold drink, impairing the spleen and stomach, and removing dampness heat decocts bile.Being located in humidity, daily life is inappropriate, and impression is cold Wet or damp and hot, affect transporting and transforming function of the spleen and stomach, it is strongly fragrant that soil stops up wood, and courage stasis is obstructed.Factors all make liver and gall functional activity of QI being not smooth, retention of damp-heat in the interior, Decocting bile and with the passing of time form cholelithiasis, cholelithiasis is existing, more can block biliary tract, makes that mechanism of qi blocks smooth further and to cause cholelithiasis the biggest. For pathogenic analysis, the syndrome-classification of primary disease, there is difference due to different medical views and viewing angle, common typing There is qi stagnation and blood stasis type, damp and hot accumulate strongly fragrant type, liver and gall deficiency of yang type, insufficiency of the spleen wet poly-type and liver-kidney yin deficiency etc..The most more authority's has The stagnation of QI listed on " the new Chinese medicine guideline of clinical investigations " that Ministry of Health of the People's Republic of China promulgates, damp and hot and septicopyemia three Individual pattern of syndrome.Due to retention of damp-heat in the interior, easily cause mechanism of qi retardance；Accumulated heat does not dissipates, pyretic toxicity fire-transformation, becomes thoroughly decomposed into pus and then becomes septicopyemia to demonstrate,prove.Clinically The differentiation of symptoms and signs for classification of syndrome of cholelithiasis is still common with damp-heat syndrome, damp and hot pent-up, and meridian qi and blood does not relaxes, therefore right epigastric discomfort, the most then angor is difficult Bearing, pain draws the shoulder back of the body；Affect liver and gall mechanism of qi, courage superinverse, then see bitter taste in the mouth and dry throat；Courage perverse and unreasonable manner violates stomach, and stomach-QI being unable to descend normally, internal organs gas is not Logical, then see nausea and vomiting, noisy pantothenic acid, constantly belch, constipation；Damp and hot stifling, the bile flowing outside the biliary passages is excessive, then, it is seen that eyeball Huang or yellow skin and eye, damp-heat flowing down to the urinary bladder, then be shown in yellowish urine.Therefore clinical treatment primary disease is when method is based on clearing away heat-damp and promoting diuresis, promoting the circulation of QI to relieve pain.

This area still expects there is the money DANTONG granule possessing excellent properties.

Summary of the invention

Present invention aim at, it is provided that the money DANTONG granule of a kind for the treatment of cholelithiasis possessing excellent properties, Yi Jiqi Preparation method.The present invention prepares money DANTONG granule by unique formula, it was thus unexpectedly found that obtained money DANTONG Granule has the performance of excellence.The present invention finds based on this and is accomplished.

To this end, first aspect present invention provides a kind of money DANTONG granule, calculate according to components by weight percent, by Herba Glechomae 10 ～1500 parts, Rhizoma Polygoni Cuspidati 10～1000 parts, Herba Taraxaci 10～1000 parts, Herba Artemisiae Scopariae 10～1000 parts, Herba Lysimachiae 10～1000 parts, pellet Join 10～500 parts, Rhizoma Cyperi (processed) 10～500 parts, Radix Bupleuri 10～500 parts, Fructus Mume 10～500 parts, Semen Cassiae 10～500 parts, then join Make with suitable adjuvant.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, calculates according to components by weight percent, by even money Grass 500～1000 parts, Rhizoma Polygoni Cuspidati 300～450 parts, Herba Taraxaci 300～450 parts, Herba Artemisiae Scopariae 450～700 parts, Herba Lysimachiae 450～700 Part, Radix Salviae Miltiorrhizae 100～250 parts, Rhizoma Cyperi (processed) 100～250 parts, Radix Bupleuri 100～250 parts, Fructus Mume 100～250 parts, Semen Cassiae 100～ 250 parts, then be equipped with suitable adjuvant and make.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, calculates according to components by weight percent, by even money Grass 700～800 parts, Rhizoma Polygoni Cuspidati 350～400 parts, Herba Taraxaci 350～400 parts, Herba Artemisiae Scopariae 500～600 parts, Herba Lysimachiae 500～600 parts, Radix Salviae Miltiorrhizae 150～200 parts, Rhizoma Cyperi (processed) 150～200 parts, Radix Bupleuri 150～200 parts, Fructus Mume 150～200 parts, Semen Cassiae 150～200 Part, then be equipped with suitable adjuvant and make.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, calculates according to components by weight percent, by even money Grass 750 parts, Rhizoma Polygoni Cuspidati 375 parts, Herba Taraxaci 375 parts, Herba Artemisiae Scopariae 562.5 parts, Herba Lysimachiae 562.5 parts, Radix Salviae Miltiorrhizae 187.5 parts, Rhizoma Cyperi (processed) 187.5 parts, Radix Bupleuri 187.5 parts, Fructus Mume 187.5 parts, Semen Cassiae 187.5 parts, then be equipped with suitable adjuvant and make.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, its every 1000g by Herba Glechomae 700～ 800g, Rhizoma Polygoni Cuspidati 350～400g, Herba Taraxaci 350～400g, Herba Artemisiae Scopariae 500～600g, Herba Lysimachiae 500～600g, Radix Salviae Miltiorrhizae 150～ 200g, Rhizoma Cyperi (processed) 150～200g, Radix Bupleuri 150～200g, Fructus Mume 150～200g, Semen Cassiae 150～200g, then it is equipped with the most auxiliary Material is made.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, its every 1000g is by Herba Glechomae 750g, tiger Cane 375g, Herba Taraxaci 375g, Herba Artemisiae Scopariae 562.5g, Herba Lysimachiae 562.5g, Radix Salviae Miltiorrhizae 187.5g, Rhizoma Cyperi (processed) 187.5g, Radix Bupleuri 187.5g, Fructus Mume 187.5g, Semen Cassiae 187.5g, then be equipped with suitable adjuvant and make.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, wherein said adjuvant is selected from: filler, Flavoring agent and combinations thereof.In one embodiment, described filler is dextrin；Its amount is generally according to experience adjustments, such as Add the loading of regulation to.In one embodiment, described flavoring agent is steviosin；Its amount generally according to experience adjustments, Generally can be in the range of 0.2%～2%, such as 0.2%～1%, such as 0.2%～0.5%.

The money DANTONG granule of any embodiment, also includes xylose in wherein said adjuvant according to a first aspect of the present invention Alcohol.In one embodiment, described xylitol accounts for the 1～5% of granule gross weight, such as 1～3%, and such as 2%.? Surprisingly it has been found that when adding a small amount of xylitol in granule, it is possible to give the property avoiding moisture absorption that granule is excellent Energy；But cannot make us explaining, this performance only has when being added with dextrin at the same time and could obtain.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, it is according to the method comprised the steps Prepare:

(1) block in ten taste medical materials being become respectively, standby；

(2) Herba Glechomae is added 8 together with Herba Lysimachiae～the water boiling and extraction of 10 times amount 1～3 hours, filter；Filtering residue adds 6 again ～8 times amount water boiling and extraction 1～2 hours, filter；Merge twice filtrate, standby；

(3) remaining eight taste medical material is added 8 together～the water boiling and extraction of 10 times amount 1～3 hours, filter；Filtering residue add 6 again～ The water boiling and extraction 1 of 8 times amount～2 hours, filter；Merge twice filtrate, standby；

(4) step (2) and step (3) gained filtrate are merged, be evaporated to relative density be 1.05～1.10 (55～ 60 DEG C) clear paste, be spray-dried, obtain extract powder, add appropriate amount of auxiliary materials, mixing, pelletize, be dried, to obtain final product.

The money DANTONG granule of any embodiment according to a first aspect of the present invention, is wherein preparing described money DANTONG In step (2) during grain, Extraction solvent water used adds 0.2～1% acetic acid, particularly with the addition of 0.2～0.5% second Acid.It has been unexpectedly discovered that when making Herba Glechomae extract together with both Herba Lysimachiaes, and add a little in Extraction solvent During acetic acid, present beat all excellent effect.

Further, second aspect present invention provides a kind of method preparing money DANTONG granule, according to components by weight percent Calculating, described money DANTONG granule is by Herba Glechomae 10～1500 parts, Rhizoma Polygoni Cuspidati 10～1000 parts, Herba Taraxaci 10～1000 parts, Herba Artemisiae Scopariae 10～1000 parts, Herba Lysimachiae 10～1000 parts, Radix Salviae Miltiorrhizae 10～500 parts, Rhizoma Cyperi (processed) 10～500 parts, Radix Bupleuri 10～500 parts, Fructus Mume 10～500 parts, Semen Cassiae 10～500 parts, then be equipped with suitable adjuvant and make；Described method comprises the steps:

(1) block in ten taste medical materials being become respectively, standby；

The method of any embodiment according to a second aspect of the present invention, wherein in step (2), Extraction solvent water used Middle interpolation 0.2～1% acetic acid, particularly with the addition of 0.2～0.5% acetic acid.It has been unexpectedly discovered that when make Herba Glechomae and Both Herba Lysimachiaes are extracted together, and when adding a little acetic acid in Extraction solvent, present beat all excellent effect.

The method of any embodiment according to a second aspect of the present invention, calculates according to components by weight percent, described money DANTONG Grain is by Herba Glechomae 500～1000 parts, Rhizoma Polygoni Cuspidati 300～450 parts, Herba Taraxaci 300～450 parts, Herba Artemisiae Scopariae 450～700 parts, Herba Lysimachiae 450～700 parts, Radix Salviae Miltiorrhizae 100～250 parts, Rhizoma Cyperi (processed) 100～250 parts, Radix Bupleuri 100～250 parts, Fructus Mume 100～250 parts, Semen Cassiae Son 100～250 parts, then be equipped with suitable adjuvant and make.

The method of any embodiment according to a second aspect of the present invention, calculates according to components by weight percent, described money DANTONG Grain is by Herba Glechomae 700～800 parts, Rhizoma Polygoni Cuspidati 350～400 parts, Herba Taraxaci 350～400 parts, Herba Artemisiae Scopariae 500～600 parts, Herba Lysimachiae 500 ～600 parts, Radix Salviae Miltiorrhizae 150～200 parts, Rhizoma Cyperi (processed) 150～200 parts, Radix Bupleuri 150～200 parts, Fructus Mume 150～200 parts, Semen Cassiae 150～200 parts, then be equipped with suitable adjuvant and make.

The method of any embodiment according to a second aspect of the present invention, calculates according to components by weight percent, described money DANTONG Grain by Herba Glechomae 750 parts, Rhizoma Polygoni Cuspidati 375 parts, Herba Taraxaci 375 parts, Herba Artemisiae Scopariae 562.5 parts, Herba Lysimachiae 562.5 parts, Radix Salviae Miltiorrhizae 187.5 parts, Rhizoma Cyperi (processed) 187.5 parts, Radix Bupleuri 187.5 parts, Fructus Mume 187.5 parts, Semen Cassiae 187.5 parts, then be equipped with suitable adjuvant and make.

The method of any embodiment according to a second aspect of the present invention, the described money every 1000g of DANTONG granule is by Herba Glechomae 700～800g, Rhizoma Polygoni Cuspidati 350～400g, Herba Taraxaci 350～400g, Herba Artemisiae Scopariae 500～600g, Herba Lysimachiae 500～600g, Radix Salviae Miltiorrhizae 150 ～200g, Rhizoma Cyperi (processed) 150～200g, Radix Bupleuri 150～200g, Fructus Mume 150～200g, Semen Cassiae 150～200g, then it is equipped with suitably Adjuvant is made.

The method of any embodiment according to a second aspect of the present invention, the described money every 1000g of DANTONG granule is by Herba Glechomae 750g, Rhizoma Polygoni Cuspidati 375g, Herba Taraxaci 375g, Herba Artemisiae Scopariae 562.5g, Herba Lysimachiae 562.5g, Radix Salviae Miltiorrhizae 187.5g, Rhizoma Cyperi (processed) 187.5g, Radix Bupleuri 187.5g, Fructus Mume 187.5g, Semen Cassiae 187.5g, then be equipped with suitable adjuvant and make.

The method of any embodiment according to a second aspect of the present invention, wherein said adjuvant is selected from: filler, flavoring agent and A combination thereof.In one embodiment, described filler is dextrin；Its amount generally according to experience adjustments, such as, adds rule to Fixed loading.In one embodiment, described flavoring agent is steviosin；Its amount is generally according to experience adjustments, the most permissible In the range of 0.2%～2%, such as 0.2%～1%, such as 0.2%～0.5%.

The method of any embodiment according to a second aspect of the present invention, also includes xylitol in wherein said adjuvant.One In individual embodiment, described xylitol accounts for the 1～5% of granule gross weight, such as 1～3%, and such as 2%.The most unexpected Ground finds, when adding a small amount of xylitol in granule, it is possible to give the performance avoiding moisture absorption that granule is excellent；But nothing Decree people explains, this performance only has when being added with dextrin at the same time and could obtain.

The performance avoiding moisture absorption of above-mentioned granule can characterize with hydroscopicity, and hydroscopicity is the lowest more good.Hydroscopicity measures Method is: makes granule be exposed in the environment of temperature 25 degrees Celsius, humidity 75% 10 hours, measures the suction before and after processing at this Wet weight, the percent that this moisture absorption weight accounts for granule initial weight is hydroscopicity.Measure whole of preparation example 1-13 gained The hydroscopicity of granule, result shows, the hydroscopicity of preparation example 10 13 batches of granules of gained in the range of 3～5%, such as 1091# The hydroscopicity of granule is 3.31%, shows that (usual hydroscopicity is gratifying less than 5% to gratifying hydroscopicity, and high It is difficult to accept in 10%)；And preparation example 1～9 and the hydroscopicity of the preparation example 11～13 whole granule of gained 14～ In the range of 23%, such as 91#, 1191#, 1291# tri-the hydroscopicity of granule be respectively 18.3%, 21.2%, 16.7%, make us not Can accept.It is known that xylitol has certain hygroscopicity, but add a small amount of xylitol but in granule of the present invention Can improve the hygroscopicity of granule, this is completely unaccountable by prior art.

Any embodiment of the either side of the present invention, can be combined with other embodiment, as long as they are not There will be contradiction.Additionally, in any embodiment of either side of the present invention, it is real that arbitrary technical characteristic goes for other Execute this technical characteristic in scheme, as long as they do not have contradiction.The invention will be further described below.

All documents recited in the present invention, their full content is incorporated herein by, and if these literary compositions Offer expressed implication and the present invention inconsistent time, be as the criterion with the statement of the present invention.Additionally, the present invention use various terms and Phrase has and well known to a person skilled in the art general sense, nonetheless, the present invention remain desirable at this these terms and Phrase is described in more detail and explains, the term mentioned and phrase are if any inconsistent with common art-recognized meanings, with institute of the present invention table The implication stated is as the criterion.

The method using the present invention hereafter " test example 1: the typical component in detection preparation ", measures preparation example 1-8 gained 8 Criticize each batch of granule obtained in granule and preparation example 10-13, index thing in these granules with reference to preparation example 1-8 preparation method Content all in the range of 1.2～1.7mg/g, such as in preparation example 1-5 granule index thing content respectively with it in preparation example 9 Middle interpolation acetic acid treatment low more than the 0.5mg/g of gained granule, shows that the Extraction solvent using interpolation acetic acid in step (2) instead is It is highly profitable.More it was unexpectedly determined that relative to other method prepare granule, preparation example 9 gained granule and Preparation example 10-13 adds, with reference to preparation example 9 preparation method, each batch of granule that the operational approach of acetic acid prepares in Extraction solvent water There is more stable character；Specifically, the method using the present invention hereafter " test example 2: the stability of granule ", measure preparation Index thing in each batch of granule obtained with reference to preparation example 1-8 preparation method in 8 batches of granules of example 1-8 gained and preparation example 10-13 Remaining percent all in the range of 86.6～90.4%, such as in preparation example 1-5 granule, index thing remnants percent is respectively To add acetic acid treatment gained granule in preparation example 9 low by more than 7% with it；The present inventor is devoted for years in medicine technical staff Make, it is possible to understand that it is higher that preparation method difference may result in the extraction ratio of some component in Chinese medicine composition, but entirely without Method understands also cannot explain that preparation method can cause the improvement of product stability, and the above results is entirely beat all.Above-mentioned Stability features is the Long-term Storage effect of product, and for the immediate status of product, particularly its biological effect is how, In the back-page pharmacodynamics test of the present invention, it is shown that the granule prepared by special process presents more excellent effect Really.

Herba Glechomae is the dry aerial parts of labiate HUOXUEDAN Glechoma longituba (Nakai) Kupr.. Spring gathered to autumn, removes impurity, dries.Herba Glechomae plant all herbal medicine.Acrid in the mouth, micro-hardship, cold nature.Return liver, kidney, bladder Warp.There is dampness removing treating stranguria, heat-clearing and toxic substances removing, effect of dissipating blood stasis for subsidence of swelling.Clinically for pyretic stranguria, stranguria caused by urinary stone, jaundice due to damp-heat, carbuncle sore swells Bitterly, traumatic injury.Herba Glechomae has choleretic effect, can promote the bile secretion of gallbladder cell, and in hepatic duct, bile increases, intrinsic pressure increasing Height, biliary tract includes muscle relaxation stuporous, and makes bile discharge.Herba Glechomae has diuresis, and decoct rat oral gavage has notable profit Urine effect, continuous application then diuresis is gradually lowered.Fiber crops alcohol rabbit test also has obvious diuresis.Herba Glechomae has dissolving Calculus effect, can make urine become acid, and makes to be present in the litholysis under the conditions of alkalescence.Herba Glechomae has bacteriostatic test, To staphylococcus aureus extreme sensitivity, from sensitivity in bacterium sonnei, escherichia coli, bacillus pyocyaneus, Bacillus typhi are the most not Sensitive.

Rhizoma Polygoni Cuspidati, Polygonum cuspidatum, the false river seven of another name, soil river seven, Rhizoma Polygoni suffulti, Radix Notoginseng or Japan's knotweed, be one Plant polygonaceae plant.Perennial herb, Rhizoma Polygoni Cuspidati is the highest, but also can grow to 3 to 4 meters.Stem has joint and hollow, just as a walking stick Equally, add the leaf of triangular form, construct similar with bamboo, but both do not have any connection in fact.The tender leaf of Rhizoma Polygoni Cuspidati is all There is the speckle of redness.Male female different strain.Rhizoma Polygoni Cuspidati originates in East Asia Region, is distributed in the area on the south Hokkaido, Japan western part, Korea half The ground such as the Jiangsu of island, Taiwan and China, Jiangxi, Shandong, Sichuan.Rhizoma Polygoni Cuspidati is used as medicine with dry rhizome and root.Rhizoma Polygoni Cuspidati has dampness removing and moves back Huang, heat-clearing and toxic substances removing, eliminating stasis to stop pain, effect of relieving cough and resolving phlegm.Clinically for jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle Swollen sore, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep beats damage, cough due to lung-heat.Compendium of Material Medica is recorded Rhizoma Polygoni Cuspidati and is ground wine clothes into powder, after managing property Blood stasis blood pain, and pendant flutter dusk vexed effectively." Mingyi Bielu " records Rhizoma Polygoni Cuspidati main tonneau moon water, broken crux of bleeding." the southern regions of the Yunnan Province book on Chinese herbal medicine " note Carry Rhizoma Polygoni Cuspidati and attack all toxic swellings, only have sore throat, diuresis, walk meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge.

Herba Taraxaci, Taraxacum mongolicum Hand.-Mazz, Compositae, Dandelion herbaceos perennial.Root Coniform, surface sepia, shrinkage, limb edge has wave-formed mouth or pinniform drastic crack, base portion the narrowest one-tenth petiole, petiole and master pulse sometimes Often band reddish violet, scape top aubergine, close by the spider's thread shape long pubescence of white；Head inflorescence, involucre mitriform, achene crineous, Long pappus white, flowering fruit bearing stage 4～October.Another name Herba crotalariae albidae, Po Poding.It is regarded as Hua Hualang in the south of the River.Compositae, is that one is many Year raw herbaceous plant.Head inflorescence, bobbles seed having white pappus form, the new place that racks after the flowers are in blossom is bred newly Life.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant. There are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Herba Taraxaci Property sweet, mildly bitter flavor, cold.There is heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds.It is usually used in heat-clearing and toxic substances removing, diuresis eliminating stagnation clinically.Control urgency Property mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchus Inflammation, gastritis, hepatitis, cholecystitis, urinary tract infection.Staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus are had relatively by Herba Taraxaci Strong bactericidal action.To Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi etc. and Micrococcus catarrhalis also has certain bactericidal action.Taraxol extract 1:400 can suppress tulase, but decoct 1:100 is invalid.Its 1:80 Water decoction ECHO11 viral cytopathic, ethanol extract (31mg/kg) can be delayed leptospira to be killed, to some fungus also There is inhibitory action.Campylobacter pylori is had good killing action.Folium Taraxacum has the obstruction of dredging breast vascular, promotes lactogenic Effect.The polysaccharide (Tof-CFr) extracted in common dandelion, with 40,2,600mg/kg ip award inoculation MM46 tumor cell C3H mouse, early stage is administered and has no effect, but is administered the most effective next day of the later stage of 11-20d and 2-20d.Slow to tumor cell Prolong type anaphylaxis (T-DHR), in ddy-Ehrlich (same tumor) is to be with C3H-MM46 (syngeneic tumor), Tof-CFr Later stage is administered its footpad reaction and the most substantially rises compared with matched group.In ADMC system, Tof-CFr be known to activate huge bite thin The glycogen of born of the same parents is compared, and has higher activation capability.Herba Taraxaci has choleretic effect, clinical treatment chronic gallbladder spasmolytic and calculus Disease is effective.The effects such as this product still has diuresis stomach invigorating in addition, hypocatharsis.

Herba Artemisiae Scopariae, Artemisia scoparia Waldst.et Kit；Latin name: ArtemisiacapillarisThunb.Another name: because of dirt, Ma Xian, Herba Artemisiae Scopariae, because of Herba Artemisiae Scopariae, capillary wormwood, floss Artemisia, spire Herba Artemisiae Annuae are smelly Artemisia, An Lvcao, grandmother Artemisia, Radix Rhapontici Artemisia.Section belongs to: Compositae.Herba Artemisiae Scopariae is dead through the winter, old of Chun Zeyin and give birth to, therefore named because of old or mattress Old.Artemisia is then become to its Seedling of summer, therefore also known as Herba Artemisiae Scopariae.Herba Artemisiae Scopariae is cool in nature, and bitter in the mouth is pungent；Enter Liver Channel, spleen channel, bladder warp, there is heat clearing away Effect of dampness removing, is mainly used in jaundice due to damp-heat, cholecystitis, dysuria, pruritus due to wind pathogen skin ulcer scabies, eczema pruritus, hygropyrexia from the beginning of.Join Cape jasmine Son, Radix Et Rhizoma Rhei control YANG jaundice, join Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis controls YIN jaundice.Herba Artemisiae Scopariae has significant hepatoprotective effect, to first, hepatitis B, icteric liver Inflammation, has significant curative effect. and there is function of gallbladder promoting, promote bile secretion, increase the effect that in bile, cholic acid and bilirubin are discharged. the heart can be increased Dirty coronary flow, improves microcirculation, and has blood pressure lowering, blood fat reducing, anticoagulation, and diuresis is antipyretic relievings asthma, and drives away ascarid and suppression Multiple pathogenic dermatophytes and the effect of antibacterial.Blood fat reducing and atherosclerosis: Herba Artemisiae Scopariae can make hyperlipidemia animal serum Cholesterol and beta lipoprotein reduce, and in aorta wall, cholesterol level substantially reduces, and arterial wall atherosclerotic plaque pathological changes alleviates. Alleviate jaundice: this product hardship diarrhea drops, heat clearing away cold in nature, kind clear profit taste dampness-heat in the liver and gallbladder, be allowed to go out from urine, for harness the Yellow River subcutaneous ulcer it Key medicine.If body mesh turns to be yellow, the YANG jaundice card of oliguria with reddish urine, normal and Fructus Gardeniae, Cortex Phellodendri, the same use of Radix Et Rhizoma Rhei, such as Herba Artemisiae Scopariae Decoction (treatise on Febrile Diseases)； If jaundice weight in wet base is in hot person, can be with Poria, Polyporus with using.Antitumor: Herba Artemisiae Scopariae water decoction is to Mouse Ehrlich Carcinoma Cells and shifting Plant MethA cell and have inhibitory or killing effect, the time-to-live of tumor-bearing mice can be extended.In Herba Artemisiae Scopariae, capillarisin and cirsimaritin have aobvious Suppression Hela cell and Ehrlich ascites cells proliferation function.It addition, Herba Artemisiae Scopariae water decoction is to carcinogen Aspergillus flavus poison Element B, the mutagenic action of (AFBl) has significant suppression.Thus releasing Herba Artemisiae Scopariae can antitumor.Antipyretic and anti-microbial effect: Herba Artemisiae Scopariae Artemisia soup, the old preserved material of Artemisia have refrigeration function to rabbit artificial fever.Herba Artemisiae Scopariae and congener Artemisiatridentata thereof and The volatile oil of A.nova, in vitro has obvious inhibitory action, to dysentery bacterium, hemolytic hammer to staphylococcus aureus Bacterium, Diplococcus pneumoniae, diphtheria corynebacterium, cattle type and Bacillus tuberculosis etc. also have certain inhibitory action.Herba Artemisiae Scopariae volatile oil is in examination Can suppress the growth of dermatosis pathogenic fungi in Guan, its antifungal effective ingredient is capillin.Body antipruritic, refreshing: Herba Artemisiae Scopariae also has Well antipyretic and itching-stopping, the effect of refreshing body, decocts soup in right amount with Herba Artemisiae Scopariae and is blended into bathing in bath water and can treat pruritus due to wind pathogen all over, scalp itch Deng disease.Choleretic effect: experiment shows Herba Artemisiae Scopariae decoct, Herba Artemisiae Scopariae Fructus Gardeniae decoct, Herba Artemisiae Scopariae Decoction (Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei are with 3:1.5:1) And alcohol extraction thing all has the effect promoting rat bile secretion, but obvious not, and the gallbladder of normal person is received by Herba Artemisiae Scopariae decoct Contracting (x-ray inspection) only performance is slightly reduced, and volume changes the most significant.The infusion of Herba Artemisiae Scopariae and refining and concentrating immersion (are removed and not Remove two kinds of volatile oil) acute gallbladder is intubated and chronic gallbladder fistula dog all has obvious choleretic effect, thus it is speculated that it effectively becomes Dividing and be probably water and alcohol-soluble material, the effect of the sleeve that volatilizees is the most suspicious or more weak；But also have been reported that, separate from the Herba Artemisiae Scopariae of Nanjing The volatile oil gone out, has choleretic effect to Cavia porcellus.Analgesia, antiinflammatory: rabbit body temperature caused by typhoid fever polyvalent vaccine is raised by Herba Artemisiae Scopariae all to be had Trivial solution heat effect, in Herba Artemisiae Scopariae 6,7-dimethyl esculetin causes pain model in mice to hot plate method and acetic acid writhing test to be had necessarily The analgesic activity of degree, and caused by Carrageenan, rat paw arthroncus degree has inhibitory action.Control neonatal jaundice: new It is the most ripe that raw youngster's jaundice mostly is hepatocyte, body broken compensation and cause, and Growth of Neonates can be affected, therefore should be early Phase treats.Herba Artemisiae Scopariae Ziziphi Jujubae Decoction has promotion hepatocyte activity, supplementing QI for promoting the production of body fluid, protects the liver effect of jaundice eliminating.This law curative effect is good, usage letter Single, have no side effect, clinic popularization and application.Hypotensive effect: the water logging agent of Herba Artemisiae Scopariae and refined immersion all have a hypotensive effect, 6,7- Dimethoxy coumarin intravenous injection and duodenal administration all show hypotensive effect to rat, cat, rabbit, dog, its hypotensive effect System may expand by maincenter and visceral vessel and cause；Isolated ventricular fibrillation Cor Leporis coronary flow is substantially increased, and makes it Recover the rhythm and pace of moving things to shrink.Impact on experimental hepatitis: experiment shows, Herba Artemisiae Scopariae Decoction, Herba Artemisiae Scopariae and gardenia-rhubarb decoct all can drop The mortality rate of low white mice carbon tetrachloride poisoning hepatitis, the infusion of Herba Artemisiae Scopariae and refining and concentrating immersion, to four chlorination flat stone with ropes attached at the sides poisonings Its choleretic effect of dog of property hepatitis is significant compared with to normal dogs, and Herba Artemisiae Scopariae decoct and Herba Artemisiae Scopariae volatile oil are to carbon tetrachloride poisoning hepatitis man The serum transaminase of rabbit is without impact, but the latter can make hepatitis rabbit appetite increase, to the white mice of viral hepatitis without improving it Mortality rate and the effect of liver cell lesion.Herba Artemisiae Scopariae Decoction decoct has promotion liver cell regeneration effect to rabbit.Diuresis: Herba Artemisiae Scopariae Infusion, refining and concentrating immersion and 6,7-dimethoxy coumarin all shows diuresis to dog；Herba Artemisiae Scopariae volatile oil centering The rabbit of virus hepatitis can make urine volume increase, and urine color is clear by xanthochromia.Thus can show that Herba Artemisiae Scopariae has the effect of diuresis.Other effects: 3 gs/kg of rabbit to experimental atherosclerosis of Herba Artemisiae Scopariae water decoction, are administered 2～3 Zhou Houke and make serum ornitrol and β-fat Protein decreased, β/γ ratio is low compared with matched group, but C/P value is higher than matched group.In other words, the Herba Artemisiae Scopariae pathological changes to aortic arch And interior fat calmness all shows protective effect.

Herba Lysimachiae, original name Herba Dichodrae, another name: Lysimachia christinae Hance, Drymoglossum subcordatum, Cui Pingcao, lotus bud grass, Boiled small dumplings with pork grass, JINSUOSHI, company Money grass etc..Latin literary fame is Dichondra repens Forst..The perennial herbelet of crawling of tubular flower mesh, Convolvulaceae.Leaf kidney Shape, to circle, diameter 4-25 millimeter, spends single leave axil, and anthocaulus is shorter than petiole, thread；Greenery, open yellow little Hua.It is distributed mainly on Two hemispheres subtropical and tropical zones.Herb hyoscine, has clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, parasite killing Merit.Can treating acute and chronic hepatitis, icterohepatitis, cholecystitis, nephritis, urinary system infection, tonsillitis, stomatitis and carbuncle furuncle are treated Poison, venom, acute mastitis, dysentery, malaria, pneumorrhagia etc..Herba Lysimachiae sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, bladder warp.Gold Money grass is a kind of frequently seen plants, and is a kind of Chinese crude drug, and its primary efficacy can prevent calculus and cholagogic and lithagogue permissible exactly Say that calculus is had the best treatment and prevention effect, relieving stranguria by diuresis；Heat-clearing and toxic substances removing；Dissipating blood stasis for subsidence of swelling, eliminating damp-heat, Sha Lin, urinates puckery Have a pain, jaundice dark coloured urine, carbuncle furuncle, cure mainly liver and gall and urinary system calculus；Pyretic stranguria；Oedema due to nephritis；Jaundice due to damp-heat；Sore carbuncle； Venom；Traumatic injury.Herba Lysimachiae herb hyoscine, has clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, parasite killing Merit.Can treating acute and chronic hepatitis, icterohepatitis, cholecystitis, nephritis, urinary system infection, tonsillitis, stomatitis and carbuncle furuncle are treated Poison, venom, acute mastitis, dysentery, malaria, pneumorrhagia etc..Calculus effect: Herba Lysimachiae has cholagogic and lithagogue and diuresis and expelling stone effect. The crystallization of the main component Calcium oxalate (CaC2O4) monohydrate CaCO HO of lithangiuria is had and presses down by the polysaccharide component in the alcohol-insoluble substances of Herba Lysimachiae Make and use.And inhibitory action increases with the increase of concentration.Herba Lysimachiae also can make blood, urine slant acidity, makes at alkaline environment The middle litholysis that could exist.Slow down CaCO HO growth rate, reduces the degree of crystal accumulation, thus is conducive to treating knot Stone.Extensively applied by modern clinic and obtain good result.The common people are usually because Herba Lysimachiae can be used for the merit of clearing away heat and promoting diuresis calculus Imitate and soaked drink when tea beverage.Choleretic effect: pharmacology and clinic confirm that truly having choleretic effect, choleretic effect may is that promotes that liver is thin Intracrine bile, in making liver and gall, bile increases, and intrinsic pressure increases, and Oddi's sphincter relaxes, and causes bile excretion to increase.Thrombosis presses down Make and use: the Lysimachia herb total flavone significant weight in wet base alleviating venous thrombosis in rat body under pathological state of energy and dry weight, reduce Thrombotic percentage rate, shows significant thrombosis inhibitory action.Strengthen immunization: cellular immunization is had suppression to make by Herba Lysimachiae With, the phagocytic function of mouse macrophage can be strengthened.Herba Lysimachiae is as organ transplantation or the immunosuppressant of oneself's immunological diseases It is useful.

Radix Salviae Miltiorrhizae, has another name called: Qie Cicadae grass (" herbal classic "), to Herba Setariae Plicatae (" four tones of standard Chinese pronunciation book on Chinese herbal medicine "), long Salvia japonica Thunb..Perennial herb is high by 30 ～80 centimetres, Herb is close by yellow-white pubescence and glandular hair.Root elongated cylindrical, crust vermilion.Old root crust loosens, many aobvious purples Brown, normal flake off.Matter is hard and crisp, and section loosens, and has crack or the most smooth and fine and close, skin zone's brownish red, woody part ash Yellow or puce, vessel cluster yellow-white, it is arranged radially.Feeble QI, mildly bitter flavor is puckery.Stem is upright, and square, there is shallow slot on surface. The month at florescence 5-8.The really phase 8-9 month.The ground such as main product Anhui, Shanxi, Hebei, Sichuan, Jiangsu.Additionally, Hubei, Gansu, Liaoning, Shan The ground such as west, Shandong, Zhejiang, Henan, Jiangxi.Radix Salviae Miltiorrhizae is perennial herb, high 30～100 centimetres, and Herb is gathered faint yellow pubescence And glandular hair.Root is elongated, cylindrical, crust soil Red.Stem four prismatic, top branch.Leaf is to life, odd number winglike compound leaf, vanelets Oval is to wide oval, and two sides is close by white pubescence.Summer-flowering, the wheel umbrella inflorescence that top is raw and axil is raw, often wheel spends 3～10 Piece, many wheels line up estranged raceme；Calyx slightly becomes mitriform, purple；Corolla 2 lip, bluish violet, grow 2, stamen, stretch out Corolla pipe is outer and is placed under upper lip, and staminodium 2 both sides being born in upper lip throat；Ovary is upper, 4 drastic cracks, and style is relatively Stamen is long, and stigma 2 sliver is unequal.Pyrene Long Circle, time ripe, burgundy or black, be wrapped in Constellation calyx.The rhizome of Radix Salviae Miltiorrhizae is short Slightly, root is elongated, slightly in elongated cylindrical, and microbend, it is about 10 to 25 centimetres, diameter 0.5 to 1.5 centimetres.Surface brownish red or brick Redness, coarse, have irregular vertical wrinkle；Crust is that squamous sheet peels off.Matter is hard and crisp.Section loosens；The dark brownish red of skin zone, wood Matter portion lark or puce；Vascular bundle yellow-white, radial arrangement., color aubergine thick with bar is preferred.July at florescence 5, the really phase August.Radix Salviae Miltiorrhizae has potentiation to the active anticancer of camptothecine, cyclophosphamide. and Radix Salviae Miltiorrhizae has cytotoxicity to meaty flavors. Isolated from Radix Salviae Miltiorrhizae have obvious anti-tumor active ingredient Przewaquinone A Przewatanshinquinone A, to Mice Bearing Lewis Lung Cancer, melanoma 1316 and Sarcoma 180 has inhibitory action in various degree. the Radix Salviae Miltiorrhizae effect to tumor, there are two kinds of different reports: have experiment to find, Radix Salviae Miltiorrhizae There is the effect promoting cancerometastasis. it is used alone Radix Salviae Miltiorrhizae Lung metastases spontaneous to Lewis lung cancer mice and is obviously promoted effect；Individually should By FUFANG DANSHEN ZHUSHEYE (containing Radix Salviae Miltiorrhizae and Lignum Dalbergiae Odoriferae), rat Walker256 cancerous cell blood is diffused with facilitation.Radix Salviae Miltiorrhizae is noted Penetrating liquid can make the cholesterol of some patients decline. and the rat of experimental atherosclerosis, oral Radix Salviae Miltiorrhizae decoct there are no fall The effect of hypolipemia, to aortic disease also unprotect effect. but to atherosclerotic rabbit, it is possible to decrease sweet in blood regulating liver-QI Oil three esters. hyperlipidemia Rabbit Model serum cholesterol, neutral fat, beta lipoprotein are also had and significantly reduce work by compound Salviae Miltiorrhizae With. Radix Salviae Miltiorrhizae and Salvia miltiorrhiza f. can suppress the formation of rabbit experiment coronary artery big branch atheromatous plaque.Radix Salviae Miltiorrhizae has promotion wound The effect of healing. the rabbit to artificial fracture, local congestion can be alleviated, improve local circulation, promote union of fracture.It promotes bone The effect of folding healing, improves serum zinc content, strengthens the mobilization of zinc in fracture site adjacent bone tissue and by improving with it Zn content in callus, that zinc/copper ratio accelerates callus tissue growth is relevant with calcification process.Additionally, Radix Salviae Miltiorrhizae decoct is to rabbit flesh Note, has hypoglycemic activity.TANSHINONES has the estrogenic activity of gentleness, and has the effect of antiandrogen.Radix Salviae Miltiorrhizae is near to rabbit kidney The protected effect of convoluted tubule epithelial cell. connective tissue pathological changes can be suppressed the synthesis of collagen by red sage formulation, promotes to decompose, available In treatment scleroderma and cicatricial disease.Radix Salviae Miltiorrhizae decoct injects 43g/kg to mouse peritoneal, has no in 48 hours l time lumbar injection Animal dead, and 10 animal deads of 64g/kg group 2.The molten part of Radix Salviae Miltiorrhizae water extracting alcohol, the median lethal of 1 lumbar injection of mice Amount is 80.5 ± 3.1g crude drug/kg, Radix Salviae Miltiorrhizae or FUFANG DANSHEN ZHUSHEYE, and the median lethal dose(LD 50) of mouse peritoneal injection is respectively 136.7 ± 3.8g/kg and 61.5g ± 5.3g/1g.(with crude drug content meter)；Rabbit lumbar injection every day Radix Salviae Miltiorrhizae Injection 2.4g/ Kg or FUFANG DANSHEN ZHUSHEYE 3g/kg, continuous 14 days, have no that toxic is reacted, and animal blood is as all nothings such as, hepatic and renal function and body weight Abnormal change, parenchymal viscera, in addition to obvious hyperemia, has no special change.It addition, mice gavage every day 2% TANSHINONES suspendible is molten Liquid 0.5ml, continuous 14 days, rat gavage 2.5ml every day, continuous 10 days, also have no toxicity.Mice by intraperitoneal injection median lethal Amount: Radix Salviae Miltiorrhizae Injection 36.7 ± 3.8g/kg, FUFANG DANSHEN ZHUSHEYE 61.5 ± 5.26g/kg.Anesthetized animal intravenous injection this two Agent reaches clinical practice amount 40～80 times also non-toxic reaction；Every day is to 20～30 times continuous 14 of rabbit vein injection quantity My god, not observe toxic reaction yet, and for hemogram, Liver and kidney function, body weight also has no adverse effects, parenchymal viscera is except bright Outside aobvious hyperemia, see special change.

Rhizoma Cyperi, original name " dried tuber ", begins to be loaded in " Mingyi Bielu ", is classified as middle product.Tang Materia Medica begins to claim Rhizoma Cyperi." book on Chinese herbal medicine guiding principle Mesh " list grass portion fragrant grass class in, name " dried tuber Rhizoma Cyperi ", and cloud: " Sha's leaf the oldest fragrant-flowered garlic leaf and hard, gloss has sword ridge rib, five, June In take out a stem Rhizoma Sparganii hollow, stem end is appeared again several leaf, opens blue and white Cheng Suiru broomcorn millet, in have thin son, its root have must, must lower knot one, two Piece, phase inversion prolongs life, and son has thin black wool, big person such as sheep Fructus Jujubae and Rhizoma Anemones Raddeanae, adopts to sing the hair, suddenly and violently dry goods it ".Rhizoma Cyperi nature and flavor: pungent Micro-hardship is sweet, flat.Rhizoma Cyperi return through: enter lung meridian, Liver Channel, spleen channel, stomach warp.Rhizoma Cyperi function: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Rhizoma Cyperi master Control: for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast. The function of Rhizoma Cyperi cures mainly: resolving depression of regulating the flow of vital energy；Menstruction regulating and pain relieving；Antiabortive.Main distending pain over the hypochondrium；Mammary swelling is educated；Hernia pain；Menoxenia； Gastral cavity abdomen feeling of fullness pain；Belch acid regurgitation, vomiting and nausea；Abdominal pain during menstruation；Bleeding not during menses；Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, gastral cavity abdomen Distending pain, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Effect of Rhizoma Cyperi: soothing the liver solution Strongly fragrant, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.The pharmacological action of Rhizoma Cyperi has a following report: the synergism to sub-threshold dose sodium pentobarbital: Liu Guoqing etc. report, to mice lumbar injection various dose Rhizoma Cyperi volatile oil 0.03,0.06 and 0.10ml/kg respectively (respectively 1/10,1/5,1/3 median lethal dose(LD 50)), it is administered latter 30 minutes, the sodium pentobarbital of the mice equal lumbar injection sub-threshold dose of each group 20mg/kg, with righting reflex loss for sleep index, observes the sleep Mus number of each group.Result shows, the Rhizoma Cyperi of various dose is waved The pentobarbital sodium syngignoscism (P < 0.01) to mice all can substantially be worked in coordination with by hair oil.Anesthetic action to normal rabbits: to family The Rhizoma Cyperi volatile oil 0.050,0.075 and 0.100mg/kg of rabbit slow intravenous injection various dose respectively, average anesthesia duration depends on Secondary is 9.0,15.0,28.5 minutes.After each treated animal is administered, righting reflex rapidly disappears, 0.050mg/kg dosage group, rabbit Pain reaction and corneal reflex are blunt, and hearing reaction exists；Remaining two dosage group rabbit pain reaction and corneal reflex are wholly absent, and listen Reaction exists.Each group rabbit the most all has orthocolosis phenomenon, disappears after about 3 minutes.Collaborative scopolamine anesthetic action: With righting reflex loss for anesthesia index, observe the average anesthesia duration of each group of rabbit.First group of intravenous injection Rhizoma Cyperi volatile oil , all there is righting reflex loss in 0.075ml/kg.Second group of intracerebroventricular scopolamine.3rd group of intravenous injection Rhizoma Cyperi volatile oil (there is not righting reflex loss) in 0.035ml/kg, subsequently intracerebroventricular scopolamine 2mg/kg, and result shows, 0.035ml/kg Dosage without anesthetic action, and the anesthesia duration of scopolamine can be extended significantly, but have no effect on depth of anesthesia.To pentylenetetrazole The impact fainted from fear: to mouse peritoneal injection Rhizoma Cyperi volatile oil 0.1ml/kg (1/3 median lethal dose(LD 50)), be administered latter 30 minutes, ih penta Tetrazolium 85mg/kg, observes mice clonism number.Result shows, the mice convulsion that pentylenetetrazole is caused by Rhizoma Cyperi volatile oil without Protective effect.SinghN etc. also report that cyperol extract is to mice pentetrazole and galvanic shock unprotect effect.Antipyretic-antalgic is made With: Deng Suzhen etc. report, to mouse subcutaneous injection 20% cyperol extract, can significantly improve the threshold of pain of mice.Liu Guoqing etc. Measure the threshold of pain with hot plate method, inject Rhizoma Cyperi volatile oil 0.1ml/kg to mouse peritoneal, oppose with lumbar injection salt morphine 10mg/kg According to, after being administered, within 15,30,60 and 90 minutes, measure the threshold of pain of each Mus.Result shows, Rhizoma Cyperi volatile oil is without the work that substantially eases pain With.GuptaMB reports, the analgesic effect that triterpenoid compound (IV mono-B) 5mg/kg contained in cyperol extract gavages with 30mg/kg aspirin is suitable.Cyperol extract has refrigeration function to the injection microbial rat fever of yeast, its titer Being about 6 times of sodium salicylate, its antipyretic effective ingredient is also triterpenoid compound.Cooling effect: to rats by intraperitoneal injection Rhizoma Cyperi Volatile oil 0.1ml/kg, makees positive control with lumbar injection chlorpromazine 5mg/kg, measures Rat-rectum body temperature before and after administration respectively. Result shows, can obviously reduce rat normal body temperature (P < 0.05), the cooling of relatively chlorpromazine after giving Rhizoma Cyperi volatile oil 30 minutes Effect is strong, but effect is lasting not as good as chlorpromazine, and rat temperature gradually recovers normal subsequently.: Soviet Union scholar Akperbekova.BA Deng report, to frog subcutaneous injection Rhizoma Cyperi water or water one alcohol extraction thing, the frog heart can be made to stop at systole.During low concentration, to from The body frog heart, and the frog heart, Cor Leporis and the cat heart have cardiotonic or decreased heart rate effect in place.Rhizoma Cyperi total alkaloids, glycoside, flavone The aqueous solution of class and phenolic compound also has heart tonifying and decreased heart rate effect, and has obvious hypotensive effect.Liu Guoqing etc. grind Study carefully the Rhizoma Cyperi volatile oil impact on cat blood pressure.Anaesthetize with chloralose 80mg/kg, record cat Blood pressure of carotid artery.Give anesthesia After cat intravenous injection Rhizoma Cyperi volatile oil 0.1ml/kg 15 seconds, cat blood pressure began to decline, and reduced 10.7-than normal arterial pressure after 150 seconds 13.3kPa, blood pressure bottom out after 5 minutes, after 8 minutes, blood pressure recovers normal level substantially.Therefore think of short duration blood pressure drops Relevant with its local action.SinghN etc. with Rhizoma Cyperi ethanol extraction 20mg/kg intravenous injection in anesthetized dog, blood pressure slowly under Fall, continues 0.5-l hour.Ethanol extraction does not affect the effect to blood pressure of epinephrine and acetylcholine, but can part blocks The effect of histamine.IndiraM etc. report, ovariectomized female rats test shows, Rhizoma Cyperi volatile oil has slight estrogenic activity.Wave Hair oil 0.2ml, interval 6h subcutaneous injection 2 times, the complete keratinization of vagina epithelium after 48 hours；When 0.3ml is administered three times, in a large number Anti-in keratinocyte there are a lot of leukocyte.The appearance of leukocyte is probably caused by the stimulation of volatile oil.From volatile oil In isolated composition, the effect with cyperene (Cyperene) I is the strongest, but not as good as volatile oil itself.During intravaginal administration, wave Hair oil, cyperene I and cyperone can cause cornification, cyperol and cyperene II then completely without effect.Effective ingredient whole body The effective dose being administered measures one times less than local application.Therefore think, these compositions may belong to proestrogen (ProesTCMLIBagen) class, increased activity after converting in vivo.This effect of Rhizoma Cyperi is the master of its treatment menoxenia Will according to one of.Send out elementary report, the 5% Rhizoma Cyperi fluid extract isolated uterine to animals such as Cavia porcellus, rabbit, cat and dogs, the most own Pregnant or unpregnancy, has inhibitory action so that it is contractility weakens, muscular tension reduces.Its interaction property is the most similar to angelicin, but relatively Weak.SinghN reports, cyperol extract 100mg/kg lumbar injection, Carrageenan and formaldehyde-caused rat swelling of the feet have bright Aobvious inhibitory action.This effect is better than 5-10mg/kg hydrocortisone.GuptaMB research proves that its anti-inflammatory component is triterpenes Compound.The wherein antiinflammatory action of swelling of the feet caused by composition IV-B Carrageenan, stronger 8 times than hydrocortisone, safety range is big 3 times.PARA FORMALDEHYDE PRILLS(91,95) swelling of the feet also has inhibitory action.The ratio of the effect of gavage and lumbar injection is 1:3, and explanation may be in digestive tract Only partially absorb.Liu Guoqing etc. report, prepare a rabbits infestines according to a conventional method, with kymograph trace Rhizoma Cyperi volatile oil to from The impact of body intestinal tube.Result shows, can suppress the contraction of intestinal tube when Rhizoma Cyperi volatile oil concentration is 5 μ g/ml, when concentration increases to During 20 μ g/ml, aobvious obvious inhibitory action, make intestinal contraction amplitude reduction, tension force decline.SinghN also reports, Rhizoma Cyperi alcohol extraction When taking thing 20 μ g/ml concentration, isolated rabbit ileum smooth muscle there is direct repression.In vitro tests, Rhizoma Cyperi volatile oil is to golden yellow Color staphylococcus has inhibitory action, invalid to other antibacterials.The bacteriostasis of cyperene I and II is stronger than volatile oil, and in Song Shigella flexneri is the most effective.Hydrogenation does not affect its antibacterial action.Cyperone is the most completely ineffective.Rhizoma Cyperi extract is to some fungus also There is inhibitory action.: the guinea pig bronchial convulsion twin protected effect caused to histamine's spraying of cyperol extract.Before contained by Rhizoma Cyperi Row parathyrine biosynthesis inhibiting substances is mainly a-cyperone (a-Cyperone).

Radix Bupleuri, clearind deficient heat Chinese medicine, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, son Palace comes off, menoxenia.Radix Bupleuri begins to be loaded in Shennong's Herbal, is classified as top grade.The phytomorph of Radix Bupleuri is had by history tree more Describe." Bencao Tujing " carries: " (Radix Bupleuri) is modern, and between pass, Shan, rivers and lakes, shortcut all has it, with silver state person for victory.Life in February Seedling, very Perfume (or spice), stem is livid purple, and leaf is the most purple like Folium Bambusae ... July opens Hemerocallis citrina Baroni ... root redness of the skin or complexion, strong like Radix Peucedani.Reed head has red hair such as rat-tail, solely Nest elder is good.August in February adopts root.Wherein red state Radix Bupleuri, assist state Radix Bupleuri, black state Radix Bupleuri figure, and the Folium Bambusae bavin of Compendium of Material Medica Hu Tu, the Radix Bupleuri figure of herbal for Relief of Famines, it is Bupleunim. L.The meridian distribution of property and flavor of Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, Gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, scattered effect of fire.The function of Radix Bupleuri cures mainly: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, rises and lifts sun Gas；Curing mainly: stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Radix Bupleuri can be used for cold, fever, and cold and heat are past Come, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.Radix Bupleuri has following pharmacology function: antipyretic: effective ingredient: volatile oil (eugenol, acid, r-undecanoic acid lactone and to methoxybenzene diketone), saikoside (sapogenin A).Effect: to typhoid fever, secondary wound The caused heating such as cold vaccine, escherichia coli liquid, fermented milk, yeast has trivial solution heat effect；And can make under animal normal body temperature Fall.Saikosaponin decoct 2g/kg all has obvious refrigeration function to rabbit gavage, the heating to causing by vaccine and temperature thorn.Antiinflammatory: Effective ingredient: saponin.Effect: to ankle joint caused by multiple proinflammatory agent is swollen and desmoplastic inflammation all has inhibitory action. Saikoside 300mg/k Radix Bupleuri g lumbar injection, can suppress the rat paw edema that carrageenin, 5-hydroxy tryptamine, histamine cause, Suppression rat granuloma swells, and adrenal gland can be made loose, atrophy of thymus gland simultaneously；Suppression inflammatory tissue histamine release and leukocyte trip Walk.Promotion immunologic function: effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves Special viral antibody titre, improves lymphocyte and turns core rate, improve skin delayed hypersensitivity reaction.Anti-liver injury: Radix Bupleuri is noted Penetrate liquid (concentration 1: 1) 1ml/ subcutaneous injection and within continuous 5 days, can dramatically the rat blood serum GPT rising that reduction carbon tetrachloride causes, liver Cytopathy and necrosis the most substantially alleviate, and in hepatocyte, glycogen and rna content are also close to normally.Antiradiation injury: Radix Bupleuri 5mg/ lumbar injection of polysaccharide, can improve the survival rate irradiating mice, and in mouse chest cell, the incorporation of 3H-TdR increases, simultaneously Accelerate the release of thymocyte cell, make again skin in blood plasma simultaneously.Matter ketone content increases, and after adrenalectomize, no longer has these to show, Therefore be considered to be realized by adrenal cortex.Anti-tubercle bacillus effect is had additionally, external.Advance on Pharmacological Activities: with Chinese medicine Pharmacological research data base connects.

Fructus Mume, another name dark plum, yellow young, conjunction Chinese prunus mume (sieb.) sieb.et zucc., dry branch prunus mume (sieb.) sieb.et zucc., for rosaceae plant deciduous tree prunus mume (sieb.) sieb.et zucc. Prunus mume's Almost ripe fruit, smokes through pyrotechnics and forms.If with Armeniaca mume Sieb. with saline Exposure to Sunlight leaching at night, having bloom to be formed after 10 days, being called bloom prunus mume (sieb.) sieb.et zucc., Its effect is similar to, and compatibility and incompatibility of drugs is identical.According to modern study. Armeniaca mume Sieb. or Fructus Armeniacae Mume juice.In Fructus Mume containing potassium many and containing sodium less, accordingly, it would be desirable to Long-term taking row potassium diuretic person preferably eats it；Fructus Armeniacae Mume China can promote enterokinesia containing catechuic acid, and therefore the people of constipation preferably eats it. Containing multiple organic acid in Fructus Armeniacae Mume, there is the effect improving liver function, therefore hepatopath preferably eats it.Prunus mume (sieb.) sieb.et zucc. acid in Fructus Armeniacae Mume can soften blood Pipe, postpones sclerosis of blood vessels, has anti-senility and makees.Fructus Mume return through: return liver, spleen, lung, large intestine channel.Effect of Fructus Mume: astringe the lung, Astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.The function of Fructus Mume cures mainly: for chronic cough of deficiency lung, chronic diarrhea chronic dysentery, and deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.

Semen Cassiae, different name: Semen Cassiae, sheep bright (" WU Pu Bencao "), Cornu Caprae seu Ovis (" the most refined "), Horse hoof Semen Cassiae (TAO Hong-Jing), also Gb 1 (" medical science main story "), bullshit bean (" the SHENGCAO property of medicine is standby to be wanted "), false Semen phaseoli radiati (" will planted by middle traditional Chinese medicines "), (" medicine is planted in Jiangsu to Horse hoof Will "), Herba Senecionis Scandentis (" Shanxi Chinese medicinal herbal)), celery is determined (" Shaanxi Chinese medicinal herbal "), swordweed (" Guangdong Chinese medicine "), wild Semen phaseoli radiati (" Jiangxi Medical herbs "), Os Sus domestica is bright, pig dung indigo plant bean, spire Herba crotalariae mucronatae, rock at night, sheep tail bean (" the main poisonous plants in south ").Semen Cassiae Taste return through for: bitter, be slightly cold.Semen Cassiae has clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, Poor vision, effect of constipation.Semen Cassiae returns liver, kidney, large intestine channel.There is effect of fat-reducing.Control wind heat acute conjunctivitis, optic atrohic blindness, passeris montani saturati Mesh, hypertension, hepatitis, cirrhotic ascites, habitual constipation.Semen Cassiae has following pharmacological action.Antibacterial action: Semen Cassiae alcohol Extract all has inhibitory action to staphylococcus, diphtheria corynebacterium, typhoid fever, paratyphoid fever, escherichia coli, and water extract is the most invalid.Anti-true Bacterium effect: Semen Cassiae water logging agent (1:4) in test tube to trichophyton gypseum, permitted blue achorion, Du big belly microspore tinea bacterium difficult to understand etc. Dermatophytes has inhibitory action in various degree.Semen Cassiae-9-anthrone Han chrysophanol, external to trichophyton, Trichophyton mentagrophytes, Sabouraudites lanosus, microsporon gypseum, silk bacterium all have relatively high inhibition effect.Hypotensive effect: Semen Cassiae infusion, alcohol-water Immersion, alcohol immersion all have hypotensive effect to anesthetized dog, cat, rabbit etc..In chronic experiment, decoct 2g every day (crude drug)/kg, without fall Pressure effect.Semen Cassiae injection 0.05g/100g body weight is injected intravenously and spontaneous genetic Hypertensive Rats can be made to shrink pressure substantially fall Low, also make diastolic pressure significantly reduce simultaneously, its antihypertensive effect, Amplitude of Hypotensive, action time are superior to intravenous injection reserpine 0.3mg/kg group rat.Impact on hyperlipemia: mice 2 week fed by the high fat beverage containing 7% Semen Cassiae, and Semen Cassiae can not Affect serum total cholesterol (TC) level, but can significantly raised Serum High-Density Lipoprotein-Cholesterol (HDL-C) content and raising HDL-C/TC ratio, is i.e. obviously improved the distribution situation of internal cholesterol, and beneficially prevention of arterial is atherosis.Antiplatelet Aggregation: the platelet that Semen Cassiae has anti-adenosine diphosphate (ADP) (ADP), arachidonic acid (AA), collagen (collagen) are induced Aggregation.3 anthraquinone compounds aurantio-obtusins in Semen Cassiae, yellow obtusin, Radix Et Rhizoma Rhei have faint antiplatelet aggregation Activity.The most also find 3 anthraquinone glycosides compound glucosyl group obtusifolines, glucosyl group aurantio-obtusin and Fructus Vitis viniferae Glycosyl Huang obtusin is respectively provided with strong inhibition on platelet aggregation.Impact on immunologic function: Semen Cassiae water decoction-alcohol sedimentation agent 15g/kg subcutaneous injection can make mouse thymus atrophy, and the negative staining rate of peripheral blood lymphocyte ANAE substantially reduces, and makes 2,4-bis- The cutaneous delayed-type allergy of chloronitrobenzene (DNCB) induced mice is suppressed, but forms serum hemolysin and have no significant effect, separately Outer Semen Cassiae water decoction-alcohol sedimentation agent can make Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell percentage rate and phagocytic index substantially increase, molten Bacterium enzyme level is also apparently higher than matched group.Hepatoprotective effect: Semen Cassiae hot water extract is administered orally 670mg/kg to carbon tetrachloride poisoning Mouse liver has weak Detoxication.Semen Cassiae extracts through petroleum ether degreasing, chloroform extraction, again with methanol, and this methanol of result carries Take thing and have significant liver protection effect.The most therefrom get chrysophanol-l-O-tri-glucose glycoside, chrysophanol-1-O-four glucose Glycoside hepatocyte to carbon tetrachloride-injured when 1mg/ml has weak protective effect, it was found that aloe-emodin also has similar anti- Liver toxicity.Discharge function: Semen Cassiae has laxative action.After its fluid extract is oral, discharge function peaks at 3-5h.From Decocting liquid obtains 50% ethanol-soluble fraction, successively with ethyl acetate, butanoic acid, respectively obtains each soluble fraction and water portion. Butanol fraction sephadex column the highest for Purgative activity is isolated several component, by active component sour water Solve, obtain identical chrysophanol, dianthrone and d-glucose.After these components oral, nitroso-group two can be detected from big enteral The condensation substance of aniline and chrysophanic acid anthrone, but the mice suppressing intestinal bacterium to breed to processing with chloromycetin, its Purgative activity Halving, anthrone generates and also reduces.Impact on gastric secretion: to having done the Canis familiaris L. of gastric fistula, can promote on an empty stomach Semen Cassiae fluid extract Enter the secretion of gastric juice.Suppression 15-Hydroxyprostaglandin: dehydrogenase (15-OH PGDH) effect has the prostaglandin of diuresis Through 15-hydroxy-prostaglandin dehydrogenase role transformation, E2 is that 15-ketone is discharged to for prostaglandin external, by suppressing this internal Reaction can make diuresis extend.Semen Cassiae aqueous extract has suppression 15-OH PGDH activity.With ethane, chloroform, methanol, water Extract successively, then analyse method separation inhibition of enzyme activity material with post, find anthraquinone derivative obtusin and the IC50 of obtusifoline Being respectively 1.064 × 10mol/, 1.666 × 10mol/L, the anthraquinone derivative chrysophanol coexisted and the IC50 of physcione divide Not being 1.789 × 10mol/L, 1.236 × 10mol/L, the equal sample of inhibitory activity is the most weak.The extract segmentation local note of Semen Cassiae Entering the Stomach duodenum etc. of rat ligation, detect with high-pressure liquid phase, the surplus of extract B is 66% (12 fingers being administered Intestinal) to 88% (colon), use colorimetry, then the dose given all can detect, and at gastrointestinal hypomere position, is detected Amount exceed given dose.At these positions, the metabolite of formation can not be measured by high-pressure liquid phase, extract B and The metabolite known only has little absorption.After Semen Cassiae extract iv is administered, with colorimetric method for determining, institute's dosage 100% is without becoming Change, illustrate its at each position of gastrointestinal tract without absorb the most non-metabolism.

Detailed description of the invention

The present invention can be conducted further description by the following examples, but, the scope of the present invention does not limit In following embodiment.One of skill in the art is it is understood that on the premise of without departing substantially from the spirit and scope of the present invention, permissible The present invention is carried out various change and modification.The present invention to test used in material and test method carry out generality And/or concrete description.Although being to it is known in the art that by realizing many materials that the object of the invention used and operational approach But the present invention still describes in detail as far as possible at this.Following example further illustrate the present invention rather than limit this Bright.

Preparation example 1: prepare money DANTONG granule

Formula (prepares money DANTONG granule 1000g): Herba Glechomae 750g, Rhizoma Polygoni Cuspidati 375g, Herba Taraxaci 375g, Herba Artemisiae Scopariae 562.5g, Herba Lysimachiae 562.5g, Radix Salviae Miltiorrhizae 187.5g, Rhizoma Cyperi (processed) 187.5g, Radix Bupleuri 187.5g, Fructus Mume 187.5g, Semen Cassiae 187.5g, steviosin 1g, dextrin make final granule weight 1000g in right amount.

Preparation method:

(1) block in ten taste medical materials being become respectively, standby；

(2) Herba Glechomae is added together with Herba Lysimachiae the water boiling and extraction 2 hours of 9 times amount, filters；Filtering residue adds 7 times amount again Water boiling and extraction 1.5 hours, filters；Merge twice filtrate, standby；

(3) remaining eight taste medical material is added together the water boiling and extraction 2 hours of 9 times amount, filters；Filtering residue adds the water of 7 times amount again Decoct and extract 1.5 hours, filter；Merge twice filtrate, standby；

Preparation example 2: prepare money DANTONG granule

Formula (prepares money DANTONG granule 1000g): Herba Glechomae 700g, Rhizoma Polygoni Cuspidati 400g, Herba Taraxaci 350g, Herba Artemisiae Scopariae 500g, Herba Lysimachiae 600g, Radix Salviae Miltiorrhizae 150g, Rhizoma Cyperi (processed) 200g, Radix Bupleuri 150g, Fructus Mume 200g, Semen Cassiae 150g, steviosin 0.5g, dextrin are suitable Amount makes final granule weight 1000g.

Preparation method:

(1) block in ten taste medical materials being become respectively, standby；

(2) Herba Glechomae is added together with Herba Lysimachiae the water boiling and extraction 1 hour of 10 times amount, filters；Filtering residue adds 6 times amount again Water boiling and extraction 2 hours, filters；Merge twice filtrate, standby；

(3) remaining eight taste medical material is added together the water boiling and extraction 3 hours of 8 times amount, filters；Filtering residue adds the water of 8 times amount again Decoct and extract 1 hour, filter；Merge twice filtrate, standby；

Preparation example 3: prepare money DANTONG granule

Formula (prepares money DANTONG granule 1000g): Herba Glechomae 800g, Rhizoma Polygoni Cuspidati 350g, Herba Taraxaci 400g, Herba Artemisiae Scopariae 600g, Herba Lysimachiae 500g, Radix Salviae Miltiorrhizae 200g, Rhizoma Cyperi (processed) 150g, Radix Bupleuri 200g, Fructus Mume 150g, Semen Cassiae 200g, steviosin 1g, dextrin are appropriate Make final granule weight 1000g.

Preparation method:

(1) block in ten taste medical materials being become respectively, standby；

(2) Herba Glechomae is added together with Herba Lysimachiae the water boiling and extraction 3 hours of 8 times amount, filters；Filtering residue adds 8 times amount again Water boiling and extraction 1 hour, filters；Merge twice filtrate, standby；

(3) remaining eight taste medical material is added together the water boiling and extraction 1 hour of 10 times amount, filters；Filtering residue adds the water of 6 times amount again Decoct and extract 2 hours, filter；Merge twice filtrate, standby；

Preparation example 4: prepare money DANTONG granule

Formula (prepares money DANTONG granule 1000g): Herba Glechomae 500g, Rhizoma Polygoni Cuspidati 450g, Herba Taraxaci 300g, Herba Artemisiae Scopariae 700g, Herba Lysimachiae 450g, Radix Salviae Miltiorrhizae 250g, Rhizoma Cyperi (processed) 100g, Radix Bupleuri 250g, Fructus Mume 100g, Semen Cassiae 250g, steviosin 1g, dextrin are appropriate Make final granule weight 1000g.

Preparation method:

(1) block in ten taste medical materials being become respectively, standby；

Preparation example 5: prepare money DANTONG granule

Formula (prepares money DANTONG granule 1000g): Herba Glechomae 1000g, Rhizoma Polygoni Cuspidati 300g, Herba Taraxaci 450g, Herba Artemisiae Scopariae 450g, Herba Lysimachiae 700g, Radix Salviae Miltiorrhizae 100g, Rhizoma Cyperi (processed) 250g, Radix Bupleuri 100g, Fructus Mume 250g, Semen Cassiae 100g, steviosin 0.5g, dextrin are suitable Amount makes final granule weight 1000g.

Preparation method:

(1) block in ten taste medical materials being become respectively, standby；

Preparation example 6: prepare money DANTONG granule (marking)

Preparation method: block in being become respectively by ten taste medical materials, adds the soak by water secondary of 8 times amount, and each 1.5 hours (wherein for the first time Add 10.5 times amount water, first soak and decoct again for 1 hour)；Collecting decoction, filters, and filtrate is concentrated into relative density 1.05～1.10 (55 ～60 DEG C) clear paste, be spray-dried, obtain extract powder, add appropriate dextrin, steviosin, mixing, pelletize, 60 DEG C of vacuum drying, make Become 1000g, to obtain final product.

Preparation example 7: prepare money DANTONG granule (632#E2)

Formula: Herba Glechomae 750g, Rhizoma Polygoni Cuspidati 375g, Herba Taraxaci 375g, Herba Artemisiae Scopariae 562.5g, Herba Lysimachiae 562.5g, Radix Salviae Miltiorrhizae 187.5g, Rhizoma Cyperi (processed) 187.5g, Radix Bupleuri 187.5g, Fructus Mume 187.5g, Semen Cassiae 187.5g.

Preparation method:

1. depletion money medical herbs material, is ground into coarse powder, adds 8 times amount 90% ethanol, after soaking 1 hour, refluxes 3 times, and each 2 Hour, merging medicinal liquid, filter, decompression filtrate recycling ethanol is also concentrated into the clear paste of relative density 1.05～1.10 (55～60 DEG C) A, standby.

2. Herba Glechomae, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, Rhizoma Cyperi (processed), Radix Bupleuri, Fructus Mume, Semen Cassiae nine taste medical material, be ground into Coarse powder, decocts secondary, each 1.5 hours, wherein adds the water (first soak 3 hours, then decoct) of 12 times amount for the first time, and second time adds The water of 10 times amount, merges medicinal liquid, filters, and filtrate is concentrated into the clear paste B of relative density 1.05～1.10 (55～60 DEG C), standby.

3. merge above-mentioned A, B, be spray-dried, obtain extract powder, add dextrin and the sweetener system of 1.4% of extract powder amount 1/3 Grain, 60 DEG C of vacuum drying, granulate, packaging, to obtain final product.

Preparation example 8: prepare money DANTONG granule (283#E3)

Formula: Herba Glechomae 1200g, Herba Lysimachiae 1500g, Rhizoma Polygoni Cuspidati 600g, Herba Artemisiae Scopariae 800g, Herba Taraxaci 800g, Radix Bupleuri 300g, pellet Ginseng 1000g, Rhizoma Cyperi 300g, Fructus Mume 200g, Semen Cassiae 200g.

Preparation method: above ten taste medical materials become respectively in block, add water for the first time 69L water, for the second time 55L water, decocts secondary, every time 1.5 hours, collecting decoction, to filter, filtrate is concentrated into relative density and is not less than the clear paste of 1.22 (55～60 DEG C), and above extractum is done Dry, it is ground into fine powder, adds cane sugar powder to 2500g, stir evenly, make granule, pack every bag of 10g, to obtain final product.

Preparation example 9: prepare money DANTONG granule: respectively referring to formula and the preparation method of preparation example 1-5, different is only at it In step (2), Extraction solvent water used adds acetic acid, its concentration is respectively 0.4%, 0.2%, 0.3%, 0.5%, 0.4%, prepare 5 batches of granule samples, sample is designated as 91#, 92#, 93#, 94#, 95# respectively.Preparation example 10: prepare money DANTONG Granule: respectively refer to formula and the preparation method of preparation example 1-9, different is only final when preparing granule, with dextrin (or sucrose Powder) it is also added with xylitol together, its amount is the 2% of final particle weight, obtains 13 batches of granule samples, and sample is designated as respectively 101#、102#、103#、104#、105#、106#、107#、108#、1091#、1092#、1093#、1094#、1095#.Preparation example 11: prepare money DANTONG granule: with reference to formula and the preparation method of preparation example 10, different is only to be replaced by the xylitol wherein added Become equivalent sorbitol, obtain 13 batches of granule samples, sample be designated as respectively 111#, 112#, 113#, 114#, 115#, 116#, 117#、118#、1191#、1192#、1193#、1194#、1195#.Preparation example 12: prepare money DANTONG granule: with reference to preparation example The formula of 10 and preparation method, different is only the mannitol that the xylitol wherein added replaces to equivalent, obtains 13 batches of granules Sample, sample be designated as respectively 121#, 122#, 123#, 124#, 125#, 126#, 127#, 128#, 1291#, 1292#, 1293#, 1294#、1295#.Preparation example 13: prepare money DANTONG granule: owing to xylitol is also filler conventional on a kind of pharmaceutics, Therefore the present embodiment is attempted using xylitol to substitute the filleies such as the dextrin used in formula or cane sugar powder；Respectively refer to preparation example The formula of 1-9 and preparation method, different is only, replaces to dextrin (or cane sugar powder) and this filler when preparing granule final The xylitol of equivalent, obtains 13 batches of granule samples, sample be designated as respectively 131#, 132#, 133#, 134#, 135#, 136#, 137#、138#、1391#、1392#、1393#、1394#、1395#。

Test example 1: the typical component in detection preparation

Herba Lysimachiae used in money DANTONG granule is its important component, to this end, such as CN101380405B (200810166632.X) described, especially Herba Lysimachiae is individually extracted when preparing money DANTONG granule, therefore measure system The Exemplary chemical component coming from Herba Lysimachiae in agent is great meaning.The typical composition of Herba Lysimachiae is Quercetin and kaempferol, The two summation is referred to herein as index thing.

[assay] measures according to high performance liquid chromatography (four general rules 0512 of version Chinese Pharmacopoeia in 2015).

Chromatographic condition and system suitability: with octadecylsilane chemically bonded silica as filler；With methanol-0.4% Phosphoric acid solution (50:50) is flowing phase；Detection wavelength is 360nm.Number of theoretical plate is calculated by Quercetin peak should be not less than 2500.

The preparation of reference substance solution: take Quercetin reference substance, kaempferol reference substance in right amount, accurately weighed, adding flowing and making mutually Become every 1ml respectively containing Quercetin 4 μ g, the solution of kaempferol 20 μ g, to obtain final product.

The preparation of need testing solution: depletion money DANTONG granule about 2g, accurately weighed, put in 50ml measuring bottle, add flowing and mix Solve and constant volume, filter, take subsequent filtrate, to obtain final product.

Algoscopy: precision draws reference substance solution and each 20 μ l of need testing solution respectively, injects chromatograph of liquid, records color Spectrogram, calculates Quercetin and the total amount of kaempferol in money DANTONG granule, due to every batch of granule Herba Lysimachiae inventory not With, therefore feed intake the Quercetin and kaempferol mg total amount (mg/g) comprised in 1g Herba Lysimachiae amount gained granule with theory, characterizes The content of the index thing in granule.After measured, with reference to preparation example 9 in five batches of granules of preparation example 9 gained and preparation example 10-13 Preparation method adds each batch of granule that the operational approach of acetic acid prepares, the content of the index thing of these granules in Extraction solvent water All in the range of 2.2～2.8mg/g.

Test example 2: the stability of granule

Granule of the present invention is placed in sealing bag, puts 40 DEG C and place 5 months, for every a collection of granule, measure it 0 Index thing content when index thing content and May during the moon, index thing content when index thing content was relative to 0 month when calculating May Percent, for the index thing remaining percent after this stability test, this remaining percent is closer to 100% and shows Granule is the most stable, if generally less than 90%, shows that preparation stability is not enough.After measured, preparation example 9 gained five batches In granule and preparation example 10-13 with reference to preparation example 9 preparation method add in Extraction solvent water acetic acid operational approach prepare each Criticizing granule, the remaining percent of the index thing of these granules is all in the range of 97.3～99.5%.

Test example 3: pharmacodynamics test

1. animal and packet: body weight 200～250gSD rat, male, weigh, by body weight random packet, blank group (including normal saline group and edible oil matched group), different preparation example granule groups.

2. experimental implementation: before experiment, water 12h, gavage normal saline 1ml/100g before anesthesia are can't help in fasting, and then every Mus is used After urethane (1g/kg) intraperitoneal injection of anesthesia, face upward position and be fixed in fixed plate.Along abdomen median line otch about 2cm, open abdominal cavity, Find stomachus pyloricus, overturn duodenum, descendant duodenum mesentery finds the bile duct of white flexible.Under bile duct Wear 2 silk threads, ligature pars papillaris, make a " V " shape otch to liver direction, insert plastic tube (seen from have faint yellow bile flow Go out), ligation is fixing, collects bile with small beaker.Used after operation hemostasis clamp closes stomach wall, covers with saline gauze.Treat stable After 20min, first collecting 30min bile, respectively group rat is administered respectively by duodenum, and blank group gives the life waiting capacity Reason saline or edible oil.After administration, every 30min collects bile 1 time, totally 3 times,

Record bile flow (ml).

3. experimental result

Experimental result is shown in Table 1.

Table 1: bile flow change (x ± S, n=10) before and after administration

As can be seen from the above results, each administration group all has certain promotion bile secretion effect.With blank group phase Ratio, difference highly significant or significant difference.And the granule using special process to prepare shows significantly superior different pharmacodynamics Result.

Money DANTONG granule of the present invention is by Herba Glechomae, Herba Lysimachiae, Herba Artemisiae Scopariae, Rhizoma Polygoni Cuspidati, Radix Bupleuri, Herba Taraxaci, Rhizoma Cyperi (system), pellet Ginseng, Semen Cassiae, Fructus Mume Ten Herbs form, and have eliminating damp-heat, dredging liver and gall, pain relieving calculus removing effect；Wet for cholelithiasis Heat stagnation is tied in the hypochondriac pain of few sun gallbladder internal organs, and pain, in right flank, is fixed and do not moved, or secondary angor, above draws the shoulder back of the body, constipation yellowish urine, even body Mesh all yellow hair heat, dimly red tongue, thick and greasy fur or yellow greasy, stringy and rolling pulse or stringy and tense pulse.

Embodiment described above is only the preferred embodiment lifted by absolutely proving the present invention, the protection model of the present invention Enclose and be not limited to this.The equivalent that those skilled in the art are made on the basis of the present invention substitutes or conversion, all in the present invention Protection domain within.Protection scope of the present invention is as the criterion with claims.

Claims

1. a money DANTONG granule, calculates according to components by weight percent, by Herba Glechomae 10～1500 parts, Rhizoma Polygoni Cuspidati 10～1000 parts, Pu Herba Taraxaci 10～1000 parts, Herba Artemisiae Scopariae 10～1000 parts, Herba Lysimachiae 10～1000 parts, Radix Salviae Miltiorrhizae 10～500 parts, Rhizoma Cyperi (processed) 10～500 parts, Radix Bupleuri 10～500 parts, Fructus Mume 10～500 parts, Semen Cassiae 10～500 parts, then be equipped with suitable adjuvant and make.

Money DANTONG granule the most according to claim 1, calculates according to components by weight percent, by Herba Glechomae 500～1000 parts, Rhizoma Polygoni Cuspidati 300～450 parts, Herba Taraxaci 300～450 parts, Herba Artemisiae Scopariae 450～700 parts, Herba Lysimachiae 450～700 parts, Radix Salviae Miltiorrhizae 100～250 parts, system Rhizoma Cyperi 100～250 parts, Radix Bupleuri 100～250 parts, Fructus Mume 100～250 parts, Semen Cassiae 100～250 parts, then it is equipped with suitable adjuvant Make.

Money DANTONG granule the most according to claim 1, calculates according to components by weight percent, by Herba Glechomae 700～800 parts, Rhizoma Polygoni Cuspidati 350 ～400 parts, Herba Taraxaci 350～400 parts, Herba Artemisiae Scopariae 500～600 parts, Herba Lysimachiae 500～600 parts, Radix Salviae Miltiorrhizae 150～200 parts, system perfume Attached 150～200 parts, Radix Bupleuri 150～200 parts, Fructus Mume 150～200 parts, Semen Cassiae 150～200 parts, then it is equipped with suitable adjuvant system Become.

Money DANTONG granule the most according to claim 1, its every 1000g is by Herba Glechomae 700～800g, Rhizoma Polygoni Cuspidati 350～400g, Pu Herba Taraxaci 350～400g, Herba Artemisiae Scopariae 500～600g, Herba Lysimachiae 500～600g, Radix Salviae Miltiorrhizae 150～200g, Rhizoma Cyperi (processed) 150～200g, bavin Recklessly 150～200g, Fructus Mume 150～200g, Semen Cassiae 150～200g, then be equipped with suitable adjuvant and make.

Money DANTONG granule the most according to claim 1, calculates according to components by weight percent, by Herba Glechomae 750 parts, Rhizoma Polygoni Cuspidati 375 parts, Pu Herba Taraxaci 375 parts, Herba Artemisiae Scopariae 562.5 parts, Herba Lysimachiae 562.5 parts, Radix Salviae Miltiorrhizae 187.5 parts, Rhizoma Cyperi (processed) 187.5 parts, Radix Bupleuri 187.5 parts, crow 187.5 parts of prunus mume (sieb.) sieb.et zucc., Semen Cassiae 187.5 parts, then be equipped with suitable adjuvant and make；Or, its every 1000g is by Herba Glechomae 750g, Rhizoma Polygoni Cuspidati 375g, Herba Taraxaci 375g, Herba Artemisiae Scopariae 562.5g, Herba Lysimachiae 562.5g, Radix Salviae Miltiorrhizae 187.5g, Rhizoma Cyperi (processed) 187.5g, Radix Bupleuri 187.5g, crow Prunus mume (sieb.) sieb.et zucc. 187.5g, Semen Cassiae 187.5g, then be equipped with suitable adjuvant and make.

Money DANTONG granule the most according to claim 1, wherein said adjuvant is selected from: filler, flavoring agent and combinations thereof；One In individual embodiment, described filler is dextrin；Its amount generally according to experience adjustments, such as, adds the loading of regulation to； In one embodiment, described flavoring agent is steviosin；Its amount in the range of 0.2%～2%, such as 0.2%～1%, example Such as 0.2%～0.5%；In one embodiment, described adjuvant also includes xylitol；In one embodiment, described Xylitol accounts for the 1～5% of granule gross weight, such as 1～3%, and such as 2%.

7., according to the money DANTONG granule of any one of claim 1-6, it is to prepare according to the method comprised the steps:

(1) block in ten taste medical materials being become respectively, standby；

(2) Herba Glechomae is added 8 together with Herba Lysimachiae～the water boiling and extraction of 10 times amount 1～3 hours, filter；Filtering residue adds 6～8 again The water boiling and extraction 1 of times amount～2 hours, filter；Merge twice filtrate, standby；

(3) remaining eight taste medical material is added 8 together～the water boiling and extraction of 10 times amount 1～3 hours, filter；Filtering residue adds 6～8 times again Amount water boiling and extraction 1～2 hours, filter；Merge twice filtrate, standby；

(4) step (2) and step (3) gained filtrate being merged, being evaporated to relative density is 1.05～1.10 (55～60 DEG C) clear paste, be spray-dried, obtain extract powder, add appropriate amount of auxiliary materials, mixing, pelletize, be dried, to obtain final product；Further, step (2) In, Extraction solvent water used adds 0.2～1% acetic acid, such as 0.2～0.5% acetic acid.

8. the method preparing money DANTONG granule, calculates according to components by weight percent, and described money DANTONG granule is by Herba Glechomae 10 ～1500 parts, Rhizoma Polygoni Cuspidati 10～1000 parts, Herba Taraxaci 10～1000 parts, Herba Artemisiae Scopariae 10～1000 parts, Herba Lysimachiae 10～1000 parts, Radix Salviae Miltiorrhizae 10～500 parts, Rhizoma Cyperi (processed) 10～500 parts, Radix Bupleuri 10～500 parts, Fructus Mume 10～500 parts, Semen Cassiae 10～500 parts, then be equipped with Suitably adjuvant is made；Described method comprises the steps:

(1) block in ten taste medical materials being become respectively, standby；

Method the most according to claim 8, calculates according to components by weight percent,

Described money DANTONG granule is by Herba Glechomae 500～1000 parts, Rhizoma Polygoni Cuspidati 300～450 parts, Herba Taraxaci 300～450 parts, Herba Artemisiae Scopariae 450～700 parts, Herba Lysimachiae 450～700 parts, Radix Salviae Miltiorrhizae 100～250 parts, Rhizoma Cyperi (processed) 100～250 parts, Radix Bupleuri 100～250 parts, crow Prunus mume (sieb.) sieb.et zucc. 100～250 parts, Semen Cassiae 100～250 parts, then be equipped with suitable adjuvant and make；Or

Described money DANTONG granule is by Herba Glechomae 700～800 parts, Rhizoma Polygoni Cuspidati 350～400 parts, Herba Taraxaci 350～400 parts, Herba Artemisiae Scopariae 500～600 parts, Herba Lysimachiae 500～600 parts, Radix Salviae Miltiorrhizae 150～200 parts, Rhizoma Cyperi (processed) 150～200 parts, Radix Bupleuri 150～200 parts, crow Prunus mume (sieb.) sieb.et zucc. 150～200 parts, Semen Cassiae 150～200 parts, then be equipped with suitable adjuvant and make；Or

Described money DANTONG granule is by Herba Glechomae 750 parts, Rhizoma Polygoni Cuspidati 375 parts, Herba Taraxaci 375 parts, Herba Artemisiae Scopariae 562.5 parts, Herba Lysimachiae 562.5 parts, Radix Salviae Miltiorrhizae 187.5 parts, Rhizoma Cyperi (processed) 187.5 parts, Radix Bupleuri 187.5 parts, Fructus Mume 187.5 parts, Semen Cassiae 187.5 parts, then join Make with suitable adjuvant；Or

The described money every 1000g of DANTONG granule is by Herba Glechomae 700～800g, Rhizoma Polygoni Cuspidati 350～400g, Herba Taraxaci 350～400g, mattress Old 500～600g, Herba Lysimachiae 500～600g, Radix Salviae Miltiorrhizae 150～200g, Rhizoma Cyperi (processed) 150～200g, Radix Bupleuri 150～200g, Fructus Mume 150～200g, Semen Cassiae 150～200g, then be equipped with suitable adjuvant and make；Or

The described money every 1000g of DANTONG granule is by Herba Glechomae 750g, Rhizoma Polygoni Cuspidati 375g, Herba Taraxaci 375g, Herba Artemisiae Scopariae 562.5g, Herba Lysimachiae 562.5g, Radix Salviae Miltiorrhizae 187.5g, Rhizoma Cyperi (processed) 187.5g, Radix Bupleuri 187.5g, Fructus Mume 187.5g, Semen Cassiae 187.5g, then be equipped with suitably Adjuvant is made.

Method the most according to claim 8, wherein said adjuvant is selected from: filler, flavoring agent and combinations thereof；An enforcement In scheme, described filler is dextrin；In one embodiment, described flavoring agent is steviosin；Its amount 0.2%～ In the range of 2%, such as 0.2%～1%, such as 0.2%～0.5%；In one embodiment, described adjuvant also includes wood Sugar alcohol；In one embodiment, described xylitol accounts for the 1～5% of granule gross weight, such as 1～3%, and such as 2%.