CN101433649A - Composition for treating gall stone symptom - Google Patents
Composition for treating gall stone symptom Download PDFInfo
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- CN101433649A CN101433649A CNA2008102202835A CN200810220283A CN101433649A CN 101433649 A CN101433649 A CN 101433649A CN A2008102202835 A CNA2008102202835 A CN A2008102202835A CN 200810220283 A CN200810220283 A CN 200810220283A CN 101433649 A CN101433649 A CN 101433649A
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Abstract
The invention relates to a composition for treating cholelithiasis, which relates to a traditional Chinese medicine composition for treating the cholelithiasis. The composition can be a granule, a capsule, a tablet, a pill, a dripping pill, powder or an oral liquid prepared by taking Longtube Ground Ivy Herb, desmodium, giant knotweed, Herba Artemisiae Capillaris, radix bupleuri, dandelion, rhizoma cyperi, Salvia miltiorrhiza, cassia seed and dark plum as raw materials. The medicine has better clinical treatment effect on damp-heat syndrome patients of the cholelithiasis differentiated by the traditional Chinese medicine, and has efficacies of clearing heat and promoting diuresis, dredging liver and gallbladder, and relieving pain and expelling stones simultaneously. The comprehensive treatment effect of the cholelithiasis is as follows: the total obvious effective rate is 54.2 percent, and the total effective rate is 90.9 percent; the composition has no clinical adverse reaction, and no adverse effect on hearts, livers, kidneys and peripheral hemogram; and the composition has a simple and feasible production method and can be applied in industrialized production in batches.
Description
Technical field
The present invention relates to the Chinese crude drug is the pharmaceutical composition of raw material, is specifically related to a kind of Chinese medicine composition for the treatment of cholelithiasis.
Background technology
Cholelithiasis is a kind of commonly encountered diseases of serious harm human health, can betide gallbladder, stones in intrahepatic bile duct and common bile duct, and its prevalence is different because of factors such as race, heredity, geography, diet.Epidemiological study shows that the cholelithiasis patient sharply increases in recent years, increases about 2 times in per ten years.Along with the progressively raising of China's living standards of the people, change has taken place in dietary structure, and the sickness rate of cholelithiasis rises rapidly.
At present the western medical treatment cholelithiasis is based on operation, but effect is unsatisfactory, exists postoperative remnant gallstone rate height, reaches 30～40%, and many weak points such as relapse rate height.Use the treatment by Chinese herbs cholelithiasis, have no contraindication, safety, side effect little, easily by plurality of advantages such as the patient accept.At present, the medicine of treatment cholelithiasis has much, but the calculus effect is undesirable, and ursodesoxycholic acid also has only slight calculus effect, and lithagogue rate is about 15%, also has lithagogue effects such as chenodeoxycholic acid, cinametic acid, trepibutone poorer.
As the Chinese medicine of treatment cholelithiasis, the greatest difficulty that faces be " attack ineffective then can not calculus; Attack too then probably the patient can not support ".And people's body constitution and symptom are widely different, and the doctor can change prescription and dose because of card because of the people at any time for the decoction that the patient opens clinically, but can not become medicine, and the patient needs prescription drugs is decocted voluntarily, and is very inconvenient.In order to be fit to the needs of extensive patients, exploitation truly has the calculus Chinese patent medicine of curative effect necessary clinically.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cholelithiasis.
The present invention seeks to be achieved through the following technical solutions for reaching: technical scheme of the present invention is based on the treatment general provisions of " clearing away heat-damp and promoting diuresis, mediation liver and gall ".First-selected Herba Glechomae, Herba Lysimachiae two medicines are monarch, and Herba Artemisiae Scopariae, Herba Taraxaci, Rhizoma Polygoni Cuspidati three medicines are minister, and Radix Bupleuri, Rhizoma Cyperi (processed), Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Mume are assistant, and Radix Bupleuri has the usefulness of guiding action again concurrently.The little hardship of Herba Glechomae acrid in the mouth, cold in nature, return liver, kidney, urinary bladder channel, the merit of " dampness removing is treating stranguria, heat-clearing and toxic substances removing " dissipating blood stasis for subsidence of swelling is arranged.Herba Lysimachiae is distinguished the flavor of little sweet, salty, cold in nature, and clearing away heat-damp and promoting diuresis is arranged, and the stasis function of soothing the liver gallbladder is so the two is a monarch drug.Herba Artemisiae Scopariae bitter in the mouth, suffering, cold in nature, it is wet specially to remove spleen, stomach, liver, gallbladder; The Rhizoma Polygoni Cuspidati mildly bitter flavor, cold nature is returned liver, gallbladder, lung meridian, expelling wind and removing dampness is arranged, the dissipating blood stasis for subsidence of swelling function.Herba Taraxaci bitter in the mouth and sweet, cold in nature is returned Liver Channel, stomach warp, clearing away heat-damp and promoting diuresis is arranged, removing pathogenic heat from blood and toxic substance from the body, mass dissipating and swelling eliminating function.This three medicines principal drug assistance remuval of damp and hot, Disperse hepatic depression is so be minister.Semen Cassiae is sweet, bitter, and cold nature is returned liver, large intestine channel, and the heat of liver heat removing is arranged and salty, and function of relaxing bowel, principal drug assistance are led damp and hot from defecating; Radix Salviae Miltiorrhizae, Rhizoma Cyperi (processed) and Radix Bupleuri match, vital energy regualting and blood circulation-promoting, but can dredge sharp liver and gall promoting blood circulation and stopping pain again, and Radix Bupleuri also can be led the through liver and gall of all medicines, is to help and the double usefulness that makes it.Fructus Mume acid, puckery and property are flat, return liver, spleen, lung, large intestine, clinical and experimental results show that, gallbladder is had contraction, can promote bile secretion, the Ovshinsky sphincter relaxes, for controlling the non-defective unit of biliary tract ascarid, cholecystitis, and also have promoting the production of body fluid to quench thirst, can prevent clearing away heat-damp and promoting diuresis too and the usefulness of impairment of body fluid liquid, so also elect adjuvant drug as.Like this compatibility, all medicines are harmonious, and become clearing away heat-damp and promoting diuresis altogether, the mediation liver and gall, the merit of pain relieving calculus makes evil must the going of pent-up and assists the pain self-balancing.
So the present invention treats the compositions of cholelithiasis, be by the water extract of the Chinese crude drug of following weight proportioning and the oral formulations that pharmaceutically acceptable excipient is made:
Herba Glechomae 10-25 part Herba Lysimachiae 4-20 part Rhizoma Polygoni Cuspidati 3-15 part
Herba Artemisiae Scopariae 5-15 part Radix Bupleuri 2-10 part Herba Taraxaci 5-20 part
Rhizoma Cyperi 1-15 part Radix Salviae Miltiorrhizae 1-15 part Semen Cassiae 1-15 part
Fructus Mume 1-15 part.
The water extract of the Chinese crude drug of preferred following weight proportioning is made:
Herba Glechomae 15-22 part Herba Lysimachiae 5-12 part Rhizoma Polygoni Cuspidati 5-12 part
Herba Artemisiae Scopariae 8-12 part Radix Bupleuri 3-6 part Herba Taraxaci 8-15 part
Rhizoma Cyperi 2-10 part Radix Salviae Miltiorrhizae 2-10 part Semen Cassiae 2-10 part
Fructus Mume 2-10 part.
The best is to be made by the water extract of the Chinese crude drug of following weight proportioning:
15 parts of 10 portions of Herba Artemisiae Scopariaes of 15 parts of Rhizoma Polygoni Cuspidati of 20 portions of Herba Lysimachiaes of Herba Glechomae
5 parts of 5 parts of Radix Salviae Miltiorrhizaes of 10 portions of Rhizoma Cyperis of 5 parts of Herba Taraxacis of Radix Bupleuri
5 parts of 5 portions of Fructus Mumes of Semen Cassiae.
Oral formulations of the present invention can add the water extract of above-mentioned medical material the adjuvant that pharmaceutically allows and adopt conventional preparation technique to be prepared into granule, capsule, tablet, pill, drop pill, powder or oral liquid.Wherein said acceptable accessories is to select according to different dosage forms.These used adjuvants can be implemented for the those of ordinary skill of pharmaceutical field.
The invention has the beneficial effects as follows: this medicine belongs to the damp-heat syndrome to treatment cholelithiasis Chinese medical discrimination, and the person has clinical efficacy preferably, truly has the effect of clearing away heat-damp and promoting diuresis, mediation liver and gall, pain relieving calculus simultaneously; The comprehensive therapeutic effect of cholelithiasis: total obvious effective rate is 54.2%, and total effective rate is 90.9%; Do not see untoward reaction clinically, the heart, liver, kidney and surrounding hemogram are had no adverse effects; Production method simple possible, suitability for industrialized production in batches.
In order to prove beneficial effect of the present invention, prove with the test of pesticide effectiveness of the present invention and clinical observation result below.
The formula agent weight range of property calculus experiment sieving pharmaceutical composition and the calculus effect of artificial calculus model of the acute common bile duct of optimum formula rabbit and compositions provided by the invention by experiment of test example one
1. material and method:
[animal] large ear rabbit, body weight 2.5-4.5kg, ♂/♀ dual-purpose.Totally 50, every test group sample is used 10 of rabbits.
[medicine] is subjected to the preparation of reagent: will prepare the Herba Glechomae, Herba Lysimachiae, Rhizoma Polygoni Cuspidati, Herba Artemisiae Scopariae, Radix Bupleuri, Herba Taraxaci, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Semen Cassiae of the present composition and Fructus Mume 10 flavor medical materials and establish compositions screen for 5 groups in agreed dosage range, every group of conventional decocting cooking method of medical material, same process conditions are extracted, and the gained extracting solution all is condensed into and contains crude drug 28.5 ± 0.3g/10mL and make test specimen.Have 5 test combinations matter samples, specifically see Table 1 and embodiment 7～11.
Table 1 test group sample
[artificial cholelithiasis] through the bonding ball of making, stiff back bag is with the two layers of plastic film by materials such as silica gel, and its hardness is not less than calculosis and not broken, diameter 2.5～4mm.
[acute choledocholithiasis operation] rabbit, pentobarbital sodium 30mg/kg removes ventral seta after (iv) anaesthetizing, and subcostal line transverse incision 4-6cm cuts corium, each layer sarolemma and peritoneum.Seek out common bile duct, common bile duct then enters 12 duodenum 12 through 2-5cm length opening.Not having other common hepatic duct around here imports to common bile duct.After determining this structure, the common hepatic duct that peeling operation is thicker is imbedded the artificial cholelithiasis of certain diameter behind the clip, and it is slowly pushed in the ductus choledochus.The common hepatic duct that ligation is cut off or implant a thin plastic pipe to the common hepatic duct that disconnects is tightened otch and is made this common hepatic duct keep gallbladder antiperspirant drain function in experiment.
After [medication] acute choledocholithiasis operation is finished, make gastric intubation.Irritate stomach medicine in contrast with dissolving Adeps Sus domestica 10ml respectively by stomach tube, observe the own control of the calculus effect (all negative) of 1-2h as test group.Give Adeps Sus domestica 10ml earlier, behind the 10-15min, press test specimen liquid and give gastric infusion 10ml for the first time, interval 10-15min is gastric infusion 10ml for the second time.After last administration, observe 1-3 hour lithagogue effect (common bile duct former put the calculus place and can touch the common bile duct scope up and down touch the calculus situation of observing.)
2. experimental result: see Table 2
Table 2 different components to the effect of the artificial calculus model of the acute common bile duct of anesthetized rabbit calculus relatively
The result: 5 test specimens all have lithagogue effect between 50-90%, and the lithagogue effect of 2,4 high dose group is also better, and selected is the best with No. 5 test specimens.On this basis, compositions 5 is continued to compare with other common drug.
Test example two optimum formulas of the present invention and other 7 kinds of medicines are to the acute choledocholithiasis model of rabbit calculus effect comparative observation
Material and method:
[animal] large ear rabbit, body weight 2.2-4.6kg, ♂/♀ dual-purpose, 42.Artificial calculus, molds, methods of making is the same.
[medicine] is subjected to reagent: No. 5 sample extracting solutions of test example one; Ursodesoxycholic acid, Changzhou pharmaceutical factory produces; Chenodeoxycholic acid, Panjin pharmacy three factories produce; Cinametic acid, Jiangpu, Nanjing pharmaceutical factory produces; Trepibutone, Xiang River pharmaceutical factory produces; Magnesium sulfate, the AR level, is produced from the Beijing Chemical Plant; Cholagogic and lithagogue tablet, the Qingdao pharmaceutical factory of traditional Chinese medicine produces.
Experimental result: see Table 3
8 kinds of medicines of table 3 to the effect of the artificial calculus model of the acute common bile duct of anesthetized rabbit calculus relatively
* use the physiological saline solution medicine, when insoluble, add suspending solvents such as a little Tween 80 as if medicine.
* conventional stomach Adeps Sus domestica 5ml. that irritates 10-15 minute time the before giving this medicine
Conclusion: from testing as seen, the strongest medicine of calculus effect is test group sample of the present invention (5/5 animal calculus), is cholagogic and lithagogue tablet (2/5) and ursodesoxycholic acid (1/6) successively, and all the other medicines are not seen the calculus effect.
Test of the calculus effect of example three samples of the present invention to the artificial calculus model of the acute common bile duct of dog:
The material method:
[animal] dog, 12 (♂ 10/ ♀ 2), 13-16kg.
[medicine and artificial cholelithiasis] medicine is with the preparation of No. 5 test group samples of test example one.
(iv) behind the anesthetized animal, the method for performing the operation and laying of markstone is identical with the rabbit operation for [acute choledocholithiasis operation] pentobarbital sodium 30mg/kg.
Experimental result: see Table 4
The calculus effect of the artificial calculus model of the acute common bile duct of table 4 pair anesthetized dog
Annotate: a dog has outward appearance silt shape nature calculus clearly in (1) test group, and in discharging artificial calculus process, sandstone obviously reduce in the bile duct, and it is limpid that color is tending towards.(2) test group dose regimen: irritate stomach with 10ml Adeps Sus domestica earlier, begin after 10 minutes, spend 10 minutes and give the 10ml sample again to 10ml sample (for the first time).(3) pentobarbital sodium 30mg/kg (iv) adds an amount of urethane and keeps anesthesia.
Conclusion: dog is being kept slight anesthesia and is being incubated under the good experiment condition, and respectively with trepibutone 40mg/ time, Adeps Sus domestica 10ml/ time and test group sample liquid (20ml) are irritated stomach, calculus situation of 1-2h procuratorial work after the administration by thin stomach tube.As a result, trepibutone and Adeps Sus domestica is individually dosed all not to have the calculus effect, and test group is irritated stomach and made all calculus in 2-3 hour of 5 animals.
The four sample clinical observations of the present invention of test example:
One, test objective
This clinical trial is combination treatment Chinese medical discrimination of the present invention to be belonged to the cholelithiasis clinical efficacy of damp-heat syndrome and toxic and side effects etc. make definite evaluation, with the positive contrast medicine of cholagogic and lithagogue tablet.
The preparation of treatment group sample: the preparation method of specifically seeing embodiment 11 oral liquids.
Two, physical data
(1) case source:
X2=0.00018, p〉0.2, two groups of case source ratio unanimities are described, comparability is arranged.
(2) two groups of comparative analysiss for the treatment of preceding stone location, size, quantity:
The distribution of two groups of stone locations is .x2=O.4658 relatively, p〉O.2, comparability is arranged.
The comparative unit of two groups of calculus sizes: mm
X:=0.7914, p〉0.2 comparability is arranged
The comparative unit of two groups of calculus numbers: individual
X2=2.39, p〉0.1 comparability is arranged
Treat preceding course of disease analysis of comparable for (three) two groups:
X2=0.8544.p〉0.2 comparability is arranged
Contrast at random, two groups are compared t=1.278 P〉0.2, the tool comparability.
The curative effect of the different courses of disease compares:
Data are analyzed through Ridit. and curative effect there was no significant difference between two groups of＜one year group and the 1 year～groups but all is higher than 2 years～group and 3 years～group; Curative effect between 2 years～group and the 3 years～group is there was no significant difference also.
Three, study subject is selected
(1) diagnostic criteria
1, tcm syndrome diagnostic criteria: upper right abdomen pain, be the paroxysmal aggravation, very then angor is unbearably, pain is drawn the shoulder back of the body, companion's sense of heaviness, fear of cold heating, bitter taste in the mouth and dry throat, nausea and vomiting, or sclera, xanthochromia, oliguria with yellow urine, big loose stool appear and not well or constipated, upper right abdominal pressure is bitterly, weight person's muscle tonus, tenderness touches the gallbladder of enlargement, red tongue sometimes, yellowish fur, wiry and frequent pulse or stringy and rolling pulse.
2, Western medicine diagnose standard:
(I) cholelithiasis: have a medical check-up: upper right abdominal pressure pain, tension of abdominal muscle can be arranged, black Fei Shi levies the positive, touches the gallbladder of enlargement sometimes.Lab testing: during with cholecystitis, can have numeration of leukocyte and neutrophilic leukocyte to increase.X ray examination: the calculus shadow can be arranged.Ultrasound diagnosis: can show gallbladder wall and calculus quantity, size etc.
(2) choledocholithiasis: have a medical check-up: yellow sclera, the epigastrium tenderness can have slight muscle tonus, may touch the enlargement gallbladder, or hepatomegaly is arranged.
Lab testing: total white blood cells and neutrophilic granulocyte increase, and urobilinogen reduces in the feces, and urobilinogen increases in the urine, serum bilirubin, and alkali phosphatase and cholesterol all increase, and bilirubin direct increases, and serum transaminase raises, the flocculation test positive.
The X X-ray inspection X: abdominal part has calculus to develop.
B ultrasonic, PTc, ERCP, inspection can show choledocholithiasis size, quantity and cholangiectasis.
Four, test method
Adopt the randomized controlled test method; The simple randomization group technology is adopted in the case grouping.
The selection of contrast medicine: select cholagogic and lithagogue tablet medicine in contrast for use.
The course of treatment: be for three weeks above two groups of courses of treatment.Dosage and medication: 1, treatment group: sample of the present invention, oral, every day four times, 20ml for the first time, back three each 10ml, every day total amount 50ml.Placebo tablet, oral each 10, every day 2 times.2, matched group: oral, each 10, every day 2 times.The blank oral liquid of placebo, oral, shake up every day 4 times, 20ml for the first time, back three each 10ml when taking.Total amount 50ml.
Curative effect determinate standard
1, comprehensive therapeutic effect:
Clinical recovery: treatment back cardinal symptom and sign all disappear, and the ultrasound diagnosis calculus disappears.
Produce effects: treatment back cardinal symptom all has obviously with sign and alleviates, and ultrasound diagnosis confirms that calculus quantity reduces and reaches more than 1/2, or the calculus smaller volume is above 1/2 above person.
Effectively: treatment back cardinal symptom all has with sign and alleviates minimizing of ultrasound diagnosis calculus quantity or calculus volume minimizing person.
Invalid: treatment back cardinal symptom does not all have change with sign, and B ultrasonic confirms that calculus quantity or volume do not have the friendship person of changing, or in treatment because PD, and need change the Therapeutic Method person.
2, traditional Chinese medical science damp-heat syndrome therapeutic effect of syndrome:
Judge according to treatment back integration and the preceding syndrome integration comparison of treatment
Be almost recovered: therapeutic index reduces 〉=90%; Produce effects: therapeutic index reduces by 〉=60% too late＜90%; Effectively: therapeutic index reduces by 〉=30% too late＜60%; Invalid: therapeutic index＜30%.
Five, result of the test
Efficacy analysis
1, the curative effect of cholelithiasis
Two groups of cholelithiasis comprehensive therapeutic effects:
Contrast two groups at random relatively, analyze through Ridit. merge into criterion group with two groups, u=4.5450, there is significant differences p＜0.01.Treatment group curative effect is better than matched group.
Cholelithiasis compares for two groups. and analyze through Ridit, merging into criterion group .u=3.975.p＜0.01. with two groups has significant differences.Treatment group curative effect is better than matched group.
Two groups of choledocholithiasis are relatively analyzed through Ridit. merge into criterion group with two groups, and u=2.741, there is significant differences p＜0.01.Treatment group curative effect is better than matched group.
Two groups of treatment back calculus disappear and big or small friendshipization:
Contrast treatment group and matched group at random relatively, analyze, merge into criterion group with two groups through Ridit, u=4.5450, there is significant differences p＜0.01.Treatment group curative effect is better than matched group.
Two groups of cholelithiasises are relatively. and analyze through Ridit, merge into criterion group with two groups, u=3.975, there is significant differences p＜0.01.Treatment group curative effect is better than matched group.
Choledocholithiasis compares for two groups. and analyze through Ridit, merge into the border standard with two groups and organize, u=2.741, there is significant differences n＜0.01.Treatment group curative effect is better than matched group.
The total effects of two groups of traditional Chinese medical science damp-heat syndrome syndromes:
Contrast two groups at random relatively, analyze, merge into criterion group with two groups through Ridit, u=5.8637, P＜0.01. has significant difference.Treatment group curative effect is better than matched group.
The dynamic change of two groups of cholelithiasis traditional Chinese medical science damp-heat syndrome syndrome integrations:
P value reflection each day (week) in the table and the previous day (week) of result relatively, the treatment group just saw that integration descended in second day, and significant difference is arranged, illustrate first day and just see curative effect, but matched group to the first is just seen significant difference after week. along with the prolongation of treatment time, integration continues to descend and significance is arranged. illustrate that every day (week), the state of an illness all continued to improve.Contrast two groups at random relatively, before controlling with control back two days, three days and there is no significant difference, one week two groups of backs significant difference is arranged.Treatment group curative effect is better than matched group.
Six, conclusion
1. sample treatment cholelithiasis 330 examples (wherein cholelithiasis 260 examples, choledocholithiasis 70 examples) of the present invention, comprehensive therapeutic effect: 43 examples that are almost recovered (13.0%), produce effects 130 examples (39.4%), effective 127 examples (38.5%), invalid 30 examples (9.1%), total obvious effective rate is 54.2%, and total effective rate is 90.9%.
2. treat the traditional Chinese medical science damp-heat syndrome therapeutic effect of syndrome of cholelithiasis 330 examples, 116 examples that are almost recovered (35.2%), produce effects 150 examples (45.5%), effective 60 examples (18.2%), invalid 4 examples (1.2%), total obvious effective rate 80.6%, total effective rate 98.8%.Illustrate that this product truly has curative effect to cholelithiasis damp-heat type patient, prove that also this product truly has the effect of clearing heat and expelling damp, depressed liver-energy dispersing and function of gallbladder promoting, pain relieving calculus.
3. the result of randomized controlled trial shows, test group comprehensive therapeutic effect and tcm syndrome curative effect are better than matched group.
4. do not see untoward reaction clinically, the heart, liver, kidney and surrounding hemogram are had no adverse effects.
This product is the safe and effective medicine of treatment cholelithiasis.
Further set forth technical scheme of the present invention below by embodiment, but be not limited to described embodiment.
The specific embodiment
The preparation of embodiment 1 capsule
Take by weighing medical material Herba Glechomae 2000g, Herba Lysimachiae 1600g, Rhizoma Polygoni Cuspidati 1200g, Herba Artemisiae Scopariae 1000g, Radix Bupleuri 800g, Herba Taraxaci 1500g, Rhizoma Cyperi 900g, Radix Salviae Miltiorrhizae 1000g, Semen Cassiae 1000g, Fructus Mume 1000g, more than ten flavor pulverize separately become in piece, add water 120L water for the first time, 96L water for the second time, decoct secondary, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.22 (55～60 ℃), and above extract dry adds Pulvis Talci and is ground into total amount 1500g, mixing, incapsulate, make 3000, every 500mg promptly.
The preparation of embodiment 2 tablets
Take by weighing medical material Herba Glechomae 1500g, Herba Lysimachiae 1000g, Rhizoma Polygoni Cuspidati 800g, Herba Artemisiae Scopariae 800g, Radix Bupleuri 500g, Herba Taraxaci 1000g, Rhizoma Cyperi 500g, Radix Salviae Miltiorrhizae 600g, Semen Cassiae 600g, piece during the above ten flavor pulverize separately of Fructus Mume 300g become adds water 76L water for the first time, for the second time 60L water, decocting boils secondary, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), above extract dry is ground into fine powder, adds Pulvis Talci a little and carboxymethyl starch sodium to total amount 1120g, mixing, granulate, be pressed into 3200, promptly.
The preparation of embodiment 3 granules
Take by weighing Herba Glechomae 1200g, Herba Lysimachiae 1500g, Rhizoma Polygoni Cuspidati 600g, Herba Artemisiae Scopariae 800g, Radix Bupleuri 300g, Herba Taraxaci 800g, Rhizoma Cyperi 300g, Radix Salviae Miltiorrhizae 1000g, Semen Cassiae 200g, Fructus Mume 200g, more than ten flavor pulverize separately become in piece, add water 69L water for the first time, 55L water decocts secondary, each 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), above extract dry, be ground into fine powder, add cane sugar powder to 2500g, stir evenly, make granule, pack every bag of 10g, promptly.
The preparation (concentrated pill) of embodiment 4 pills
Take by weighing Herba Glechomae 2300g, Herba Lysimachiae 1800g, Rhizoma Polygoni Cuspidati 1200g, Herba Artemisiae Scopariae 1500g, Radix Bupleuri 300g, Herba Taraxaci 1500g, Rhizoma Cyperi 200g, Radix Salviae Miltiorrhizae 1200g, Semen Cassiae 600g, Fructus Mume 1000g, more than ten flavor pulverize separately become in piece, add water 116L water for the first time, for the second time 92L water, decoct secondary, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), above extract dry is pulverized, and adds an amount of Pulvis Talci, carboxymethyl starch sodium and makes soft material to 1700g, make 4000 balls again, promptly.
The preparation of embodiment 5 drop pills
Take by weighing Herba Glechomae 1000g, Herba Lysimachiae 500g, Rhizoma Polygoni Cuspidati 300g, Herba Artemisiae Scopariae 500g, Radix Bupleuri 300g, Herba Taraxaci 600g, Rhizoma Cyperi 150g, Radix Salviae Miltiorrhizae 200g, Semen Cassiae 100g, Fructus Mume 100g, more than ten flavor pulverize separately become in piece, add water 37L water for the first time, 30L decocts secondary for the second time, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), taking polyethylene glycol, heating and melting, add above-mentioned extractum, mixing drips and makes ball, promptly.
The preparation of embodiment 6 powders
Take by weighing Herba Glechomae 1500g, Herba Lysimachiae 1000g, Rhizoma Polygoni Cuspidati 800g, Herba Artemisiae Scopariae 700g, Radix Bupleuri 500g, Herba Taraxaci 1000g, Rhizoma Cyperi 800g, Radix Salviae Miltiorrhizae 700g, Semen Cassiae 800g, Fructus Mume 400g, more than ten flavor pulverize separately become in piece, add the water water of 82L for the first time, the water of 65L for the second time, decoct secondary, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), above extract dry, crushing fine powder, add soluble starch to 3000g, mixing is packed every bag of 10g, promptly.
The preparation of embodiment 7 oral solutionses
Take by weighing Herba Glechomae 1000g, Herba Lysimachiae 400g, Rhizoma Polygoni Cuspidati 300g, Herba Artemisiae Scopariae 500g, Radix Bupleuri 200g, Herba Taraxaci 500g, Rhizoma Cyperi 100g, Radix Salviae Miltiorrhizae 100g, Semen Cassiae 100g, Fructus Mume 100g, more than ten flavor pulverize separately become in piece, add the water of 43L for the first time, the water of 29L decocts secondary for the second time, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.22 (55～60 ℃), and clear paste adds water and is mixed with 1260ml, embedding, packing, every 10ml, promptly.
The preparation of embodiment 8 oral solutionses
Take by weighing Herba Glechomae 2500g, Herba Lysimachiae 2000g, Rhizoma Polygoni Cuspidati 1500g, Herba Artemisiae Scopariae 1500g, Radix Bupleuri 1000g, Herba Taraxaci 2000g, Rhizoma Cyperi 1500g, Radix Salviae Miltiorrhizae 1500g, Semen Cassiae 1500g, Fructus Mume 1500g, more than ten flavor pulverize separately become in piece, add the water of 200L for the first time, the water of 132L decocts secondary for the second time, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.22 (55～60 ℃), and clear paste adds water and is mixed with 5800ml, embedding, packing, every 10ml, promptly.
The preparation of embodiment 9 oral solutionses
Take by weighing Herba Glechomae 1500g, Herba Lysimachiae 500g, Rhizoma Polygoni Cuspidati 500g, Herba Artemisiae Scopariae 800g, Radix Bupleuri 300g, Herba Taraxaci 800g, Rhizoma Cyperi 200g, Radix Salviae Miltiorrhizae 200g, Semen Cassiae 200g, Fructus Mume 200g, more than ten flavor pulverize separately become in piece, add the water of 63L for the first time, the water of 42L decocts secondary for the second time, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), and clear paste adds water and is mixed with 1800ml, embedding, packing, every 10ml, promptly.
The preparation of embodiment 10 oral solutionses
Take by weighing Herba Glechomae 2200g, Herba Lysimachiae 1200g, Rhizoma Polygoni Cuspidati 1200g, Herba Artemisiae Scopariae 1200g, Radix Bupleuri 600g, Herba Taraxaci 1500g, Rhizoma Cyperi 1000g, Radix Salviae Miltiorrhizae 1000g, Semen Cassiae 1000g, Fructus Mume 1000g, more than ten flavor pulverize separately become in piece, add the water of 143L for the first time, the water of 95L decocts secondary for the second time, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), and clear paste adds water and is mixed with 4200ml, embedding, packing, every 10ml, promptly.
The preparation of embodiment 11 oral solutionses
Take by weighing Herba Glechomae 2000g, Herba Lysimachiae 1500g, Rhizoma Polygoni Cuspidati 1000g, Herba Artemisiae Scopariae 1500g, Radix Bupleuri 500g, Herba Taraxaci 1000g, Rhizoma Cyperi 500g, Radix Salviae Miltiorrhizae 500g, Semen Cassiae 500g, Fructus Mume 500g, more than ten flavor pulverize separately become in piece, add the water of 115L for the first time, the water of 76L decocts secondary for the second time, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is not less than 1.22 (55～60 ℃), and clear paste adds water and is mixed with 3300ml, embedding, packing, every 10ml, promptly.
Claims (4)
1, a kind of compositions for the treatment of cholelithiasis is characterized in that said composition is by the water extract of the Chinese crude drug of following weight proportioning and the oral formulations that pharmaceutically acceptable excipient is made:
Herba Glechomae 10-25 part Herba Lysimachiae 4-20 part Rhizoma Polygoni Cuspidati 3-15 part
Herba Artemisiae Scopariae 5-15 part Radix Bupleuri 2-10 part Herba Taraxaci 5-20 part
Rhizoma Cyperi 1-15 part Radix Salviae Miltiorrhizae 1-15 part Semen Cassiae 1-15 part
Fructus Mume 1-15 part.
2, the compositions of treatment cholelithiasis according to claim 1 is characterized in that being made by the water extract of the Chinese crude drug of following weight proportioning:
Herba Glechomae 15-22 part Herba Lysimachiae 5-12 part Rhizoma Polygoni Cuspidati 5-12 part
Herba Artemisiae Scopariae 8-12 part Radix Bupleuri 3-6 part Herba Taraxaci 8-15 part
Rhizoma Cyperi 2-10 part Radix Salviae Miltiorrhizae 2-10 part Semen Cassiae 2-10 part
Fructus Mume 2-10 part.
3, the compositions of treatment cholelithiasis according to claim 2 is characterized in that being made by the water extract of the Chinese crude drug of following weight proportioning
15 parts of Rhizoma Polygoni Cuspidati 1C of 20 portions of Herba Lysimachiaes of Herba Glechomae part
10 parts of 5 parts of Herba Taraxacis of 15 parts of Radix Bupleuri of Herba Artemisiae Scopariae
5 parts of 5 parts of Semen Cassiaes of 5 parts of Radix Salviae Miltiorrhizaes of Rhizoma Cyperi
5 parts of Fructus Mumes.
4, the compositions of treatment cholelithiasis according to claim 1 is characterized in that described oral formulations is granule, capsule, tablet, pill, drop pill, powder or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102202835A CN101433649A (en) | 2008-12-24 | 2008-12-24 | Composition for treating gall stone symptom |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102202835A CN101433649A (en) | 2008-12-24 | 2008-12-24 | Composition for treating gall stone symptom |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587287A (en) * | 2015-03-03 | 2015-05-06 | 北京石匠远洋医药科技有限公司 | Traditional Chinese medicine formula for treating and preventing liver and gall stone and urinary calculi |
| CN105878655A (en) * | 2016-06-03 | 2016-08-24 | 贵州威门药业股份有限公司 | Herba lysimachiae eulektrol particles for treating cholelithiasis |
| CN106038904A (en) * | 2016-06-03 | 2016-10-26 | 贵州威门药业股份有限公司 | Herba lysimachiae and eulektrol particle composite and preparation method |
-
2008
- 2008-12-24 CN CNA2008102202835A patent/CN101433649A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587287A (en) * | 2015-03-03 | 2015-05-06 | 北京石匠远洋医药科技有限公司 | Traditional Chinese medicine formula for treating and preventing liver and gall stone and urinary calculi |
| CN105878655A (en) * | 2016-06-03 | 2016-08-24 | 贵州威门药业股份有限公司 | Herba lysimachiae eulektrol particles for treating cholelithiasis |
| CN106038904A (en) * | 2016-06-03 | 2016-10-26 | 贵州威门药业股份有限公司 | Herba lysimachiae and eulektrol particle composite and preparation method |
| CN106038904B (en) * | 2016-06-03 | 2019-12-20 | 贵州威门药业股份有限公司 | Lysimachia christinae and cholangiopsis cochinchinensis granule composition and preparation method thereof |
| CN105878655B (en) * | 2016-06-03 | 2019-12-20 | 贵州威门药业股份有限公司 | Jinqianlitong granules for treating cholelithiasis |
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Open date: 20090520 |