CN106036802A - Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules - Google Patents
Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules Download PDFInfo
- Publication number
- CN106036802A CN106036802A CN201610344842.8A CN201610344842A CN106036802A CN 106036802 A CN106036802 A CN 106036802A CN 201610344842 A CN201610344842 A CN 201610344842A CN 106036802 A CN106036802 A CN 106036802A
- Authority
- CN
- China
- Prior art keywords
- selenium
- grifola frondosa
- capsule
- capsules
- enriched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011669 selenium Substances 0.000 title claims abstract description 79
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 79
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 78
- 239000002775 capsule Substances 0.000 title claims abstract description 71
- 240000001080 Grifola frondosa Species 0.000 title claims abstract description 63
- 235000007710 Grifola frondosa Nutrition 0.000 title claims abstract description 63
- 230000036039 immunity Effects 0.000 title claims abstract description 31
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000000694 effects Effects 0.000 claims abstract description 56
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 43
- 239000000284 extract Substances 0.000 claims abstract description 29
- 238000002156 mixing Methods 0.000 claims abstract description 17
- 238000011049 filling Methods 0.000 claims abstract description 11
- 239000007902 hard capsule Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 17
- 238000005498 polishing Methods 0.000 claims description 10
- 230000002950 deficient Effects 0.000 claims description 5
- 239000000945 filler Substances 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 239000003797 essential amino acid Substances 0.000 abstract description 2
- 235000020776 essential amino acid Nutrition 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 2
- 239000011707 mineral Substances 0.000 abstract description 2
- 235000010755 mineral Nutrition 0.000 abstract description 2
- 239000011782 vitamin Substances 0.000 abstract description 2
- 235000013343 vitamin Nutrition 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract description 2
- 230000001766 physiological effect Effects 0.000 abstract 1
- 229940091258 selenium supplement Drugs 0.000 description 60
- 241000699670 Mus sp. Species 0.000 description 10
- 230000037396 body weight Effects 0.000 description 8
- 235000013376 functional food Nutrition 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 230000036737 immune function Effects 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 206010057249 Phagocytosis Diseases 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 230000008782 phagocytosis Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001541 thymus gland Anatomy 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 241000252335 Acipenser Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108010006464 Hemolysin Proteins Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 210000004712 air sac Anatomy 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000003228 hemolysin Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 241000222382 Agaricomycotina Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000019926 Keshan disease Diseases 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 241000222383 Polyporales Species 0.000 description 1
- 206010039921 Selenium deficiency Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000005961 cardioprotection Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000002864 mononuclear phagocyte Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 125000002081 peroxide group Chemical group 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000701 toxic element Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to selenium-enriched grifola frondosa capsules having the efficacy of enhancing immunity and a preparation method of the selenium-enriched grifola frondosa capsules. The selenium-enriched grifola frondosa capsules are made through the steps of thoroughly mixing a grifola frondosa extract with selenium-enriched yeast, and filling hard capsules with the obtained mixture so as to make the selenium-enriched grifola frondosa capsules. The capsules disclosed by the invention integrate and have the advantages of the grifola frondosa extract and the selenium-enriched yeast, have various activity physiological effects, and contain essential amino acids, vitamins and minerals; and besides, inorganic selenium can be converted into organic selenium, so that the absorptivity of selenium is improved, the toxicity is reduced, the selenium-enriched grifola frondosa capsules have prominent efficacies in immunity improving respects, and not only can the nonspecific immunity of bodies be adjusted, but also the specific immunity of the bodies can be adjusted.
Description
Technical field
The present invention relates to field of health care food, be specifically related to a kind of selenium-rich ash tree Air Bladder pseudosciaenae seu Acipenser with enhancing immunity effect
Capsule and preparation method thereof.
Background technology
Grifola frondosa is the precious pharmaceutical fungi and edible fungi of a kind of great Development volue, belongs to Basidiomycotina, and Hymenomycetes, without every load
Daughter bacteria subclass, Aphyllophorales, Polyporaceae, have another name called hen of the woods, thousand Buddhist bacterium, Semen Castaneae mushroom, hen of the woods etc., Japan is referred to as to wave young pilose antler.
What in Grifola frondosa, more people were attracted attention is its biological active substances grifolan.Grifolan is
A kind of fungus polysaccharide being separated to from Grifola Frondosa sporophore, has carried out the fungus as biological response modifier both at home and abroad in a deep going way
The research of polysaccharide, the significant curative effect of grifolan is the most gradually recognized by people.Send out through substantial amounts of chemistry and pharmacology analysis
Existing, grifolan has obvious antitumor, anti HIV-1 virus, improves function of immune system, and regulation blood glucose, blood fat and gallbladder are solid
Alcohol level, the effect such as blood pressure lowering, to prevent the generation of cancerous cell and transfer, acquired immune deficiency syndrome (AIDS), hypertension, obesity, diabetes and
The disorder of function of immune system has certain curative effect, and without any side effects.
Selenium is as the essential trace element of human body, at the decomposition of peroxide and the removing of free radical, immunity of organisms
Regulation, the aspect such as antagonism of toxic element play an important role, and it can prevent and suppress tumor, defying age, maintenance painstaking effort
The normal structure of guard system and function, prevention of arterial hardening and the appearance of coronary heart disease.Although inorganic selenium and organic selenium can be made
Preventing and treat the selenium deficiency of human body for selenium source, but inorganic selenium toxicity is big, absorbance is low；Yeast rich in selenium is to be given birth to by yeast
The autonomous of selenium is absorbed and convert by growth process, makes selenium protein in yeast body and polysaccharide organic be combined, eliminate chemistry
The selenium (such as the sub-selenium sodium nitrate) toxic and side effects to human body, yeast rich in selenium may be provided for some while providing selenium simultaneously
Protein, the nutrient substance such as aminoacid, be the functional food ingredient of a kind of non-convention.
Yeast rich in selenium has enhancing body immunity, prevents and treats Keshan disease, Kaschin-Beck disease, cardioprotection, cardiovascular, anti-ageing
Always, auxiliary treats the effects such as diabetes.Yeast rich in selenium owing to edible safety is strong, bioavailability advantages of higher and become first-selected
Selenium supplement additive.
Along with society and economic progress, the raising of people's living standard, the development of science and technology, the change of disease pattern
And the pursuit to good health and a long life, the functional food of enhancing immunity the deepest people's popular feeling, people have started to from heavily treating
Turning to and heavily prevent, this will be greatly promoted the development of the functional food of enhancing immunity.China has this function of edible fungi
Property the huge treasure-house of food and other characteristic resources, we should be in conjunction with the functional food development trend of enhancing immunity and China
The impetus of development, makes great efforts to excavate precious resources, develops the functional food of enhancing immunity with Chinese characteristics.
For the present situation of Chinese people, the number using functional food is relatively fewer, and common reason is functional food
The selling at exorbitant prices of product, simultaneously during using functional food, the active substance directly obtained by human body is less, obtains per capita
Taken amount is few especially, and particularly grifolan and the intake of yeast rich in selenium, the most few.
Summary of the invention
For the problems referred to above, for strengthening national immunity function, the invention discloses one and there is enhancing immunity effect
Selenium-rich Grifola frondosa capsule and preparation method thereof, produced by technique advanced, science, reduce production cost, remain simultaneously
Grifola frondosa and the effective ingredient of yeast rich in selenium, it is ensured that Grifola frondosa and yeast rich in selenium effectively absorb.
For solving above technical problem, present invention provide the technical scheme that
A kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, it is characterised in that by following component
Constituting: Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium, the weight proportion of described Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium is respectively 95 ~
99.9% and 0.1 ~ 5%；
Above-mentioned a kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, wherein, described preparation side
Method comprises the following steps:
(1) assort up-to-standard Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium by weight ratio, and proceed in clean area, standby；
(2) Effects of Extracts of Grifola frondosa on Active in step (1), yeast rich in selenium are crossed respectively 100 mesh sieves, standby；
(3) use equal increments method, the amount of yeast rich in selenium is incremented by and mixes to Effects of Extracts of Grifola frondosa on Active, until it reaches Grifola frondosa carries
Take the weight proportion of thing and yeast rich in selenium, obtain the raw material that proportioning is good；
(4) raw material good for the proportioning obtained in step (3) is put into mixer mixing so that material mix homogeneously, mixed
Raw material, standby；
(5) by capsule filling machine, the mixing raw material and the Capsules that step (4) are obtained are separately added into capsule filler, fill out
Fill into the hard capsule of required loading amount.
(6) the capsule addition capsule polishing machine after filling carries out capsule polishing, rejects the defective capsule of outward appearance simultaneously.
(7) being packed by qualified capsule, capsule 's content is 260mg/ grain.
The invention have the benefit that
A kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect of the present invention and preparation method thereof, by Effects of Extracts of Grifola frondosa on Active
Be sufficiently mixed with yeast rich in selenium, be packed in hard capsule, formulate, the capsule of the present invention comprehensive and possessed Effects of Extracts of Grifola frondosa on Active and
The advantage of yeast rich in selenium, has a various active physiological action, and the essential amino acids that contains and vitamin, mineral, meanwhile,
Inorganic selenium can be converted into organic selenium, thus improve the absorbance of selenium, reduce toxicity, especially have prominent in terms of improving immunity
Effect, can not only improve the nonspecific immunity regulation of body, and can improve the specific immunity regulation of body.
Detailed description of the invention
Embodiment one
A kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, it is characterised in that by following component
Constitute: Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium, the weight proportion of described Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium is respectively 95% He
5%；
Above-mentioned a kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, wherein, described preparation side
Method comprises the following steps:
(1) assort up-to-standard Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium by weight ratio, and proceed in clean area, standby；
(2) Effects of Extracts of Grifola frondosa on Active in step (1), yeast rich in selenium are crossed respectively 100 mesh sieves, standby；
(3) use equal increments method, the amount of yeast rich in selenium is incremented by and mixes to Effects of Extracts of Grifola frondosa on Active, until it reaches Grifola frondosa carries
Take the weight proportion of thing and yeast rich in selenium, obtain the raw material that proportioning is good；
(4) raw material good for the proportioning obtained in step (3) putting into mixer mixing, speed setting is 2000R/min, mixing
25min so that material mix homogeneously, obtains mixing raw material, standby；
(5) by capsule filling machine, the mixing raw material and the Capsules that step (4) are obtained are separately added into capsule filler, fill out
Fill into the hard capsule of required loading amount；
(6) the capsule addition capsule polishing machine after filling carries out capsule polishing, rejects the defective capsule of outward appearance simultaneously；
(7) being packed by qualified capsule, capsule 's content is 260mg/ grain.
Embodiment two
A kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, it is characterised in that by following component
Constitute: Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium, the weight proportion of described Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium is respectively 97.5% He
2.5%；
Above-mentioned a kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, wherein, described preparation side
Method comprises the following steps:
(1) assort up-to-standard Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium by weight ratio, and proceed in clean area, standby；
(2) Effects of Extracts of Grifola frondosa on Active in step (1), yeast rich in selenium are crossed respectively 100 mesh sieves, standby；
(3) use equal increments method, the amount of yeast rich in selenium is incremented by and mixes to Effects of Extracts of Grifola frondosa on Active, until it reaches Grifola frondosa carries
Take the weight proportion of thing and yeast rich in selenium, obtain the raw material that proportioning is good；
(4) raw material good for the proportioning obtained in step (3) putting into mixer mixing, speed setting is 3000R/min, mixing
23min so that material mix homogeneously, obtains mixing raw material, standby；
(5) by capsule filling machine, the mixing raw material and the Capsules that step (4) are obtained are separately added into capsule filler, fill out
Fill into the hard capsule of required loading amount；
(6) the capsule addition capsule polishing machine after filling carries out capsule polishing, rejects the defective capsule of outward appearance simultaneously；
(7) being packed by qualified capsule, capsule 's content is 260mg/ grain.
Embodiment three
A kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, it is characterised in that by following component
Constitute: Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium, the weight proportion of described Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium is respectively 99.9% He
0.1%；
Above-mentioned a kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, wherein, described preparation side
Method comprises the following steps:
(1) assort up-to-standard Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium by weight ratio, and proceed in clean area, standby；
(2) Effects of Extracts of Grifola frondosa on Active in step (1), yeast rich in selenium are crossed respectively 100 mesh sieves, standby；
(3) use equal increments method, the amount of yeast rich in selenium is incremented by and mixes to Effects of Extracts of Grifola frondosa on Active, until it reaches Grifola frondosa carries
Take the weight proportion of thing and yeast rich in selenium, obtain the raw material that proportioning is good；
(4) raw material good for the proportioning obtained in step (3) putting into mixer mixing, speed setting is 3500R/min, mixing
21min so that material mix homogeneously, obtains mixing raw material, standby；
(5) by capsule filling machine, the mixing raw material and the Capsules that step (4) are obtained are separately added into capsule filler, fill out
Fill into the hard capsule of required loading amount；
(6) the capsule addition capsule polishing machine after filling carries out capsule polishing, rejects the defective capsule of outward appearance simultaneously；
(7) being packed by qualified capsule, capsule 's content is 260mg/ grain.
The selenium-rich Grifola frondosa capsule of the present invention is using " function of health food assessment process and method of inspection specification " as inspection
Gauge model, carries out enhancing immunity functional check through sanitary analysis test center of Shandong University, and assay is:
1. body weight, thymus/body weight ratio, spleen/body weight ratio: 0.087g/kg BW/d, 0.173g/kg BW/d, 0.520g/
During kg BW/d (being equivalent to 5 times of human body recommended intake, 10 times, 30 times) dosage, body weight, the thymus/body weight ratio to animal
Have no significantly affect with spleen/body weight ratio.
2. the mouse spleen lymphocyte conversion test (mtt assay) of ConA induction: 0.173g/kg BW/d, 0.520g/kg
During BW/d (being equivalent to 10 times of human body recommended intake, 30 times) dosage, there is the effect strengthening mouse cell immunologic function.
3. mice Tardive allergy (the foot sole of the foot thickens method): 0.520g/kg BW/d (is equivalent to human body recommended intake
30 times) dosage time, have strengthen mouse cell immunologic function effect.
4. antibody-producting cell detection (Jerne improves slide method): 0.173g/kg BW/d, 0.520g/kg BW/d (phase
When in 10 times, 30 times of human body recommended intake) dosage time, mouse antibodies cellulation number can be increased, there is enhancing Mice Body
The effect of liquid immunologic function.
5. serum hemolysin measures: at 0.087g/kg BW/d, 0.173g/kg BW/d, 0.520g/kg BW/d (quite
In human body recommended intake 5 times, 10 times, 30 times) dosage time, on mice serum hemolysin level without impact, to mice body fluid
Immunologic function has no and significantly affects.
6. mice carbonic clearance test: when 0.520g/kg BW/d (being equivalent to 30 times of human body recommended intake) dosage, have
Strengthen the effect of mononuclear phagocyte phagocytosis in mice.
7. Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell test (half intracorporal method): 0.173g/kg BW/d, 0.520g/
During kg BW/d (being equivalent to 10 times of human body recommended intake, 30 times) dosage, there is the effect strengthening mice phagocytosis carefully energy.
8.NK cytoactive detection (determination of lactate dehydrogenase method):: 0.087g/kg BW/d, 0.173g/kg BW/d,
During 0.520g/kg BW/d (being equivalent to 5 times of human body recommended intake, 10 times, 30 times) dosage, to NK cells in mice activity nothing
Impact.
Experiment conclusion is as follows: per os gives the Grifola frondosa capsule 30 days with mice various dose, increases Mouse Weight invariably
Good impact is on mouse spleen body weight ratio and thymus body weight ratio without impact, the monocytes/macrophages phagocytic function of mice, thin
Born of the same parents' immunologic function, humoral immune function measurement result are the positive, and NK cytoactive detection result is negative.Result shows, ash
Tree Air Bladder pseudosciaenae seu Acipenser capsule has the effect of enhancing immunity function.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto,
Any those familiar with the art in the technical scope that the invention discloses, the change that can readily occur in or replacement,
All should contain within the scope of the present invention.Therefore, protection scope of the present invention should be with the protection domain of claims
It is as the criterion.
Claims (2)
1. selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, it is characterised in that by following group
Point constituting: Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium, the weight proportion of described Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium is respectively 95 ~
99.9% and 0.1 ~ 5%.
A kind of selenium-rich Grifola frondosa capsule with enhancing immunity effect and preparation method thereof, its
Being characterised by, described preparation method comprises the following steps:
(1) assort up-to-standard Effects of Extracts of Grifola frondosa on Active and yeast rich in selenium by weight ratio, and proceed in clean area, standby；
(2) Effects of Extracts of Grifola frondosa on Active in step (1), yeast rich in selenium are crossed respectively 100 mesh sieves, standby；
(3) use equal increments method, the amount of yeast rich in selenium is incremented by and mixes to Effects of Extracts of Grifola frondosa on Active, until it reaches Grifola frondosa carries
Take the weight proportion of thing and yeast rich in selenium, obtain the raw material that proportioning is good；
(4) raw material good for the proportioning obtained in step (3) is put into mixer mixing so that material mix homogeneously, mixed
Raw material, standby；
(5) by capsule filling machine, the mixing raw material and the Capsules that step (4) are obtained are separately added into capsule filler, fill out
Fill into the hard capsule of required loading amount；
(6) the capsule addition capsule polishing machine after filling carries out capsule polishing, rejects the defective capsule of outward appearance simultaneously；
(7) being packed by qualified capsule, capsule 's content is 260mg/ grain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610344842.8A CN106036802A (en) | 2016-05-24 | 2016-05-24 | Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610344842.8A CN106036802A (en) | 2016-05-24 | 2016-05-24 | Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106036802A true CN106036802A (en) | 2016-10-26 |
Family
ID=57176599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610344842.8A Pending CN106036802A (en) | 2016-05-24 | 2016-05-24 | Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106036802A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260770A (en) * | 2017-07-03 | 2017-10-20 | 广州健码医药生物科技有限公司 | A kind of immunity that improves is used for the composition of chemoradiation therapy |
| CN109645414A (en) * | 2019-02-22 | 2019-04-19 | 江西汪氏蜜蜂园有限公司 | A kind of royal jelly selenium soft capsule and its preparation process |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194917A (en) * | 2007-11-21 | 2008-06-11 | 贵州大学 | Grifola frondosa oral liquid rich in gastrodine, organic selenium and method for preparing the same |
| CN102114112A (en) * | 2011-02-28 | 2011-07-06 | 辽宁盛生医药集团有限公司 | Effervescent tablet for improving immunity and preparation method thereof |
| CN104223070A (en) * | 2014-09-11 | 2014-12-24 | 深圳市荣格科技有限公司 | Health food with immunity enhancing function and preparation method of health food |
| CN104435004A (en) * | 2014-10-20 | 2015-03-25 | 唐山市容大保健品有限公司 | Assistant blood sugar-reducing tablets |
| CN105267251A (en) * | 2015-10-20 | 2016-01-27 | 李显堂 | Compound preparation with grifola frondosa (maitake) polysaccharides, lycopene and selenium and application of compound preparation |
-
2016
- 2016-05-24 CN CN201610344842.8A patent/CN106036802A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194917A (en) * | 2007-11-21 | 2008-06-11 | 贵州大学 | Grifola frondosa oral liquid rich in gastrodine, organic selenium and method for preparing the same |
| CN102114112A (en) * | 2011-02-28 | 2011-07-06 | 辽宁盛生医药集团有限公司 | Effervescent tablet for improving immunity and preparation method thereof |
| CN104223070A (en) * | 2014-09-11 | 2014-12-24 | 深圳市荣格科技有限公司 | Health food with immunity enhancing function and preparation method of health food |
| CN104435004A (en) * | 2014-10-20 | 2015-03-25 | 唐山市容大保健品有限公司 | Assistant blood sugar-reducing tablets |
| CN105267251A (en) * | 2015-10-20 | 2016-01-27 | 李显堂 | Compound preparation with grifola frondosa (maitake) polysaccharides, lycopene and selenium and application of compound preparation |
Non-Patent Citations (1)
| Title |
|---|
| 黄琬凌 等: ""免疫调节功能壳寡糖胶囊的研制"", 《食品研究与开发》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260770A (en) * | 2017-07-03 | 2017-10-20 | 广州健码医药生物科技有限公司 | A kind of immunity that improves is used for the composition of chemoradiation therapy |
| CN107260770B (en) * | 2017-07-03 | 2020-08-25 | 广州健码医药生物科技有限公司 | Composition for improving immunity and assisting radiotherapy and chemotherapy |
| CN109645414A (en) * | 2019-02-22 | 2019-04-19 | 江西汪氏蜜蜂园有限公司 | A kind of royal jelly selenium soft capsule and its preparation process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Rizzo et al. | A review of mushrooms in human nutrition and health | |
| CN104187624A (en) | Comprehensive nutrition powder and preparation method thereof | |
| CN104186654B (en) | A kind of manufacture method of the lentinus edodes health care milk beverage with calcium supplementing effect | |
| CN107212397A (en) | A kind of compound nutritional powder of edible fungus | |
| CN1919056A (en) | Processing and use of foodstuff or health food comprising elaeagnus conferta fruits | |
| CN102144748A (en) | Five-color flour food with functions of excreting toxins, protecting liver and maintaining beauty | |
| CN103385925B (en) | Fructus cannabis enzymolysis fermentation liquor having fatigue resistance and its preparation method and use | |
| CN102755346A (en) | Compound polysaccharide formula of edible fungus as well as preparation method and application thereof | |
| CN107028166A (en) | A kind of selenium-rich formula food of pre- anti-cancer and preparation method thereof | |
| CN104126785A (en) | Composition with function of lowering blood sugar and preparation method thereof | |
| CN107439795A (en) | A kind of feed addictive and its preparation technology containing compound marine alga | |
| CN106509142A (en) | Mycelium fluid health-care product and preparation method thereof | |
| CN106036802A (en) | Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules | |
| CN105614860A (en) | Probiotic compound oligopeptide nutritional supplement capable of lowering uric acid | |
| CN107485025A (en) | A kind of Zinc-rich saccharomyces cerevisiae chewable tablets and preparation method thereof | |
| CN106822190A (en) | A kind of formula of strengthen immunity, composition and preparation method thereof | |
| CN105747093A (en) | Zinc-supplementing health porridge | |
| CN104224883A (en) | Capsule for enhancing bone mineral density and preparation method thereof | |
| CN1051714C (en) | Traditional Chinese patent medicine for strengthening spleen and appetizing and its preparation method | |
| CN106923342A (en) | A kind of selenium-rich passion fruit amino acid lozenge and preparation method thereof | |
| CN106616152A (en) | Manufacturing method of tremella fermented solid beverage | |
| CN104606659A (en) | Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity | |
| CN104106799A (en) | Composition with effect of removing vivo-toxins and preparation method thereof | |
| CN1813790A (en) | Tablet auxiliary product for increase of body immunological competence | |
| CN107136490A (en) | A kind of peptide Chinese caterpillar fungus health product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |