CN104223070A - Health food with immunity enhancing function and preparation method of health food - Google Patents
Health food with immunity enhancing function and preparation method of health food Download PDFInfo
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- CN104223070A CN104223070A CN201410460871.1A CN201410460871A CN104223070A CN 104223070 A CN104223070 A CN 104223070A CN 201410460871 A CN201410460871 A CN 201410460871A CN 104223070 A CN104223070 A CN 104223070A
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- health food
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention provides health food with an immunity enhancing function. The health food is prepared from the following raw materials in parts by weight: 5-10 parts of red flowers, 8-15 parts of coix seeds, 10-15 parts of lentinula edodes, 5-10 parts of angelica sinensis, 8-15 parts of radix codonopsis, 8-15 parts of wolfberry fruit, 5-10 parts of epimedium, 5-10 parts of semen cuscutae, 5-10 parts of Chinese chive seeds, 5-10 parts of folium ginkgo and 5-25 parts of auxiliary materials. The health food with the immunity enhancing function has the following advantages that the internal environments of visceral organs of a human body are conditioned, so that the immunity and the organ disease resistance ability of the human body are comprehensively and systematically enhanced; various traditional Chinese medicines containing polysaccharose effective components are reasonably mixed, and all the components are in a good dose-response relationship; compounding is essence of the traditional Chinese medicines, and compound polysaccharide can improve the activity of single polysaccharide; the health food takes a quick response, is safe, does not have toxic and side effects and tastes good; the bitterness of traditional Chinese medicines can be eliminated, and the problem that the traditional Chinese medicines are hard to take is prevented.
Description
Technical field
The present invention relates to nutritional health food, particularly relate to a kind of health food with develop immunitypty and preparation method thereof.
Background technology
Body immunity is the ability of human defense's disease, and it is realized by the function of immune system of human body.Normal immune system defends the shield of health, and the internal environment that it can maintain organism metabolism is in stable state.Once immune system abnormality, very easily cause bacterium, the infection such as virus, the most directly performance is exactly liable to illness.Current medical research shows, threatens the numerous disease of human health all to have close relationship with the immunity of human body.The chronic diseases such as chronic bronchitis, asthma, chronic pharyngitis, allergic rhinitis, chronic enterogastritis, chronic hepatitis, diabetes, even some fearful disorders such as cancers, angiocardiopathies etc., all relevant to immunity.At present, the main reason that the No.1 formidable enemy " inferior health " of human life produces also is that autoimmune function lowly causes.
The traditional Chinese medical science think disease generation, develop and lapse to the growth and decline depending on good and evil, emphasize " strengthening vital QI to eliminate pathogenic factors ", wherein " heresy " just refers to all paathogenic factors, " righting " be exactly strengthen human body to the defence capability of paathogenic factor.Human righteousness is vigorous, and perverse trend is just not easy invasion, even if perverse trend invasion, and also can be unlikely sick because healthy tendency resists.
The traditional Chinese medical science is thought, kidney storing essence, main bone, and the kidney being the origin of congenital constitution; Blood stored in the liver, main catharsis; Lung governing qi, department breathes, the imbalance of liver kidney, impairment of dispersing and descending function of the lung cause negative and positive of qi and blood uncomfortable, positive unsaturated vapor and immunogenicity is low, the basic ideas of traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors are conceived to the functional state regulating human body just, strengthen resistance against diseases, transfer the overall defense function of human body, describe in Ancient Times in China book on Chinese herbal medicine there is enhanced machine body immunity function (strengthening vital QI to eliminate pathogenic factors) in a large number Chinese medicine as mushroom, matrimony vine, Radix Angelicae Sinensis, barrenwort, Radix Codonopsis, safflower, ginkgo leaf etc.Therefore, the Chinese medicine and health food of research and development develop immunitypty function, for improving national physique, improving national life quality has extremely important meaning.At present, market is sold can develop immunitypty product category numerous, but mostly have following defect: product side effect is comparatively large, should not long-term, heavy dose of taking; Supplementary various vitamin, amino acid is had in product, also certain effect is had after taking, but stop using after very short a period of time, immunity can decline again, do not reach and fundamentally improve human internal organ internal environment, make human body self possess effect of immunity; Select the product that Chinese medicine is made, still have Chinese medicine bitter taste, mouthfeel difference causes not easily long-term taking.
Summary of the invention
The technical problem to be solved in the present invention is to provide the good and health food with develop immunitypty of enhanced machine body immunity function of a kind of mouthfeel, has the preparation method of the health food of develop immunitypty described in the present invention additionally provides simultaneously.
The invention provides a kind of health food with develop immunitypty, be made up of the raw material of following parts by weight:
Described auxiliary material is at least one in Fruit powder, diluent, adhesive, lubricant, sweetener and flavoring essence.
Described Fruit powder is at least one in orange powder, strawberry powder, apple powder, blueberry powder, pomegranate powder, cherry powder and Cranberry powder; Described diluent is at least one in starch, Icing Sugar, dextrin, microcrystalline cellulose and inorganic salts; Described adhesive is at least one in starch slurry, sodium carboxymethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose and PVP K30; Described lubricant is at least one in dolomol, talcum powder and polyethylene glycol; Described sweetener is at least one in white granulated sugar, glucose, fructose, xylitol, sweet mellow wine, antierythrite, acesulfame potassium, Sucralose and Aspartame.
The invention provides a kind of health food with develop immunitypty, be made up of the raw material of following parts by weight:
Described auxiliary material is made up of the component of following parts by weight:
Described health food is pulvis, granule, tablet and hard capsule.
The preparation method of the pulvis of the health food of described develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, wherein pressure is 0.2Mpa ~ 0.3Mpa, concentrated 4-5 doubly, filtrate is concentrated into relative density 1.15 ~ 1.20, obtains medicinal extract, and medicinal extract is put in reduced vacuum drying cupboard and is drying to obtain dry cream;
(2) above-mentioned dry cream is pulverized through pulverizer, cross 60-100 mesh sieve; Mix through equal increments method together to the auxiliary material of the above-mentioned corresponding parts by weight crossing 60-100 mesh sieve, then be placed in three-dimensional mixer and mix, then adopt asepticize automated packaging equipment to pack, i.e. the pulvis of the health food of obtained develop immunitypty.
The preparation method of the granule of the health food of described develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, and second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, and wherein pressure is 0.2Mpa ~ 0.3Mpa, and concentrated 4-5 doubly, filtrate is concentrated into relative density 1.15 ~ 1.20, obtains medicinal extract;
(2) above-mentioned concentrated medicinal extract is dropped in efficient wet granulator to the auxiliary material of above-mentioned corresponding parts by weight make softwood; wet granular is made through swing granule; then wet granular is placed in drying box and carries out drying process; dried particle is after the whole grain of pelletizing machine; asepticize automated packaging equipment is adopted to pack, i.e. the granule of the health food of obtained develop immunitypty.
The preparation method of the hard capsule of the health food of described develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, wherein pressure is 0.2Mpa ~ 0.3Mpa, doubly, obtain medicinal extract, filtrate is concentrated into relative density 1.15 ~ 1.20 to concentrated 4-5, medicinal extract is put in reduced vacuum drying cupboard dry, namely gets dry extract;
(2) above-mentioned dry cream is pulverized through pulverizer, cross 60-100 mesh sieve; Mix to the auxiliary material equal increments method of the above-mentioned corresponding parts by weight crossing 60-100 mesh sieve, be placed in three-dimensional motion mixer again to mix, then through Autocapsulefillingmachine filled capsules, polishing is carried out to populated capsule, the hard capsule of the health food of the immunity that is namely enhanced.
The preparation method of the tablet of the health food of described develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, and second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, and wherein pressure is 0.2Mpa ~ 0.3Mpa, and concentrated 4-5 doubly, filtrate is concentrated into relative density 1.15 ~ 1.20, obtains medicinal extract;
(2) by above-mentioned medicinal extract to pulverize after above-mentioned corresponding parts by weight auxiliary material except lubricant drop in efficient wet granulator and make softwood; wet granular is obtained with oscillating granulator; then wet granular carries out drying process at drying box; dried particle is through the whole grain of pelletizing machine; particle after whole grain and lubricant always mix; the particle mixed adopts high speed tablet press to carry out compressing tablet, i.e. the tablet of the health food of obtained develop immunitypty.
The present invention, on the basis of theory of traditional Chinese medical science, filters out the Chinese medicine with warm filling liver kidney, strengthening the bones and muscles and establishing-Yang controlling nocturnal emission with astringent drugs, carries out scientific compatibility, play it and mutually act synergistically, thus make a kind of Chinese medicine and health food with develop immunitypty function.
1. in Ricipe for health care food of the present invention: safflower, activating blood to promote menstruation, blood stasis removing analgesic; Coix seed, invigorating the spleen excreting dampness, except numbness antidiarrheal; Mushroom, Gan Ping, " beneficial gas, not hungry, control wind and break blood "; Radix Angelicae Sinensis, enriches blood and invigorates blood circulation, and relaxes bowel; Radix Codonopsis, Gan Ping, returns spleen, lung channel, tonifying middle-Jiao and Qi, clearing lung-heat of promoting the production of body fluid, beneficial lung qi; The fruit of Chinese wolfberry, Gan Ping, enters liver, kidney channel, nourishing the liver nourshing kidney, moistening lung; Barrenwort, Gan Wen, returns liver, kidney channel, tonifying kidney and strengthening yang, strengthening the bones and muscles; The seed of Chinese dodder, Xin Gan, tepor; Return liver,kidney,spleen warp, tonifying kidney and nourishing yin, nourish the liver to improve visual acuity; Leek seed, pungent, sweet, temperature.Return kidney, Liver Channel, warm filling liver kidney, establishing-Yang controlling nocturnal emission with astringent drugs; Ginkgo leaf, promoting blood circulation and stopping pain, astringes the lung and relievings asthma.All medicines share, temperature compensation liver, kidney, and tonifying Qi benefit essence, Yin nourishing and lung moistening, enriches blood and invigorate blood circulation, strengthening vital QI to eliminate pathogenic factors.
2. Chinese medicine safflower, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry and barrenwort in Ricipe for health care food of the present invention are after water extraction is got, main composition is polysaccharose substance, and described polysaccharose substance mainly comprises the plant macromolecular polysaccharides such as safflower polysaccharide, lentinan, Radix Angelicae Sinensis polysaccharide, Codonopsis pilosula polysaccharide, LBP-X and epimedium brevicornum polysaccharide.These plant macromolecular polysaccharides have multiple physiological action to human body, can significantly improve body immunity, and concrete function arranges as follows in detail:
A. safflower polysaccharide: have immunoloregulation function, can promote the proliferation function of human peripheral blood single nucleus cell (PBMC), improves PBMC secretion of gamma-IFN, IL-2, also can improve NK cells of human beings and LAK cell killing activity.
B. lentinan: be a typical T cell reinforcing agent; inside and outside all can promote the generation of cytotoxic T lymphocyte (CTL); and improve the killing activity of CTL; strengthen delayed allergy (DTH) that is normal or immunologic hypofunction mouse; improve antibody dependent, promote the generation of interferon (IFN).Large quantifier elimination proves: lentinan has stronger antitumor activity and conditioner body immunity function.
C. Radix Angelicae Sinensis polysaccharide: there is adjustment immunity of organism, affect hemopoietic system, the multiple effect such as antiviral, antitumor and anti-oxidant; Radix Angelicae Sinensis polysaccharide significantly can strengthen the propagation of mouse boosting cell and peritoneal macrophage.
D. Codonopsis pilosula polysaccharide: normal mouse antibodies is generated and has humidification, immune response can be strengthened, Codonopsis pilosula polysaccharide can activate Phagocytosis By The Peritoneal Macrophages In Mice, and the weight of mouse immune organ spleen, thymus gland can be increased, improve macrophage phagocytic index, also can promote that normal lymphocytes is bred.
E. LBP-X: research shows that LBP-X has antifatigue, enhance tolerance, anti-aging, neuroprotective, control blood sugar, the effect such as anti-oxidant, antitumor, and can develop immunitypty, to body non-specific immune function and cellular immunity and humoral immunity, all there is significant regulating action; Mouse gavaging LBP-X, finds that there is the phagocytic function improving macrophage.
F. epimedium brevicornum polysaccharide: by the impact on spleen antibody-producting cell, had both increased spleen antibody-producting cell number, had promoted again each they produce antibodies, had the effect of develop immunitypty.
3. to sum up, the invention provides a kind of health food with develop immunitypty, tool has the following advantages compared with the existing health food with develop immunitypty:
(1) the present invention has the health food of develop immunitypty from aspect conditioning human internal organ internal environments such as warm filling liver kidney, tonifying Qi benefit essence, Yin nourishing and lung moistenings, thus comprehensive and systematic enhancing body immunity and body resistance against diseases.
(2) health food that the present invention has a develop immunitypty provides the multiple Chinese medicine containing polysaccharide functional component, carry out the rational proportion of prescription, each component presents good dose-effect relationship, compound is the marrow of Chinese medicine, its complex polysaccharide also just can improve the activity of single polysaccharide, and curative effect is fast, safety and having no side effect.
(3) Fruit powder (comprising orange powder, strawberry powder, apple powder, blueberry powder, pomegranate powder, cherry powder, the one or more kinds of combination of Cranberry powder) selected of the present invention and each Chinese medicine are combined together, mouthfeel is good, Chinese medicine bitter taste can be eliminated, avoid the problem not easily taken.
(4) health food that the present invention has a develop immunitypty makes tablet, pulvis, granule and hard capsule.Tablet tool has the following advantages: 1. dosage is accurate, content even, using sheet number as dosage unit taking convenience; 2. because small volume, fine and close, the impact by outside air, light, water grading factors is little, and chemical stability is better; 3. carry, transport, take all more convenient; The mechanization of 4. producing, automaticity are large compared with high, output, cost and price lower.Pulvis, granule have the following advantages: 1. adopt packaging of aluminium foil bag, and compactness is good, and the impact by factors such as outside air, light, water is little; 2. be easily absorbed by the body, soon effective.Hard capsule has the following advantages: 1. smooth appearance, attractive in appearance, makes people be easy to accept, conveniently takes; 2. bioavilability is high, can not add adhesive, do not pressurize in preparation process, compared with tablet, and effective fast, the good absorbing of hard shell capsules; 3. good stability, the sealing function of capsule shells, makes the medicine in capsule from the invasion and attack of the oxygen in extraneous moisture, air and heat, thus improves the stability of content; 4. production technology is simple, and production cost is low.
Detailed description of the invention
The each component of health food of develop immunitypty of the present invention all adopts existing commercially available prod, and all traditional Chinese medicinal material raw materials and safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf all meet the quality requirement of the Pharmacopoeia of the People's Republic of China (2010 editions one); Auxiliary material meets corresponding national food safety standard.
The invention provides a kind of health food of develop immunitypty, be made up of the raw material of following parts by weight:
Described auxiliary material is at least one in Fruit powder, diluent, adhesive, lubricant, sweetener and flavoring essence.
Described Fruit powder is at least one in orange powder, strawberry powder, apple powder, blueberry powder, pomegranate powder, cherry powder and Cranberry powder; Described diluent is at least one in starch, Icing Sugar, dextrin, microcrystalline cellulose and inorganic salts; Described adhesive is at least one in starch slurry, sodium carboxymethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose and PVP K30; Described lubricant is at least one in dolomol, talcum powder and polyethylene glycol; Described sweetener is at least one in white granulated sugar, glucose, fructose, xylitol, sweet mellow wine, antierythrite, acesulfame potassium, Sucralose and Aspartame.
The health food of described develop immunitypty is made into pulvis, granule, tablet and hard capsule.
Following examples 1-4 takes (unit: kilogram) according to the component shown in table 1 and weight.
Table 1
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Safflower | 5 | 8 | 10 | 5 |
| Coix seed | 8 | 15 | 10 | 10 |
| Mushroom | 10 | 10 | 12 | 15 |
| Radix Angelicae Sinensis | 5 | 5 | 8 | 10 |
| Radix Codonopsis | 10 | 8 | 10 | 15 |
| The fruit of Chinese wolfberry | 15 | 10 | 10 | 8 |
| Barrenwort | 10 | 10 | 5 | 8 |
| The seed of Chinese dodder | 10 | 8 | 5 | 9 |
| Leek seed | 8 | 8 | 10 | 5 |
| Ginkgo leaf | 9 | 8 | 10 | 5 |
| Antierythrite | 4.97 | ? | ? | ? |
| Acesulfame potassium | 0.03 | ? | ? | ? |
| White granulated sugar | ? | 5 | ? | 2 |
| Strawberry powder | 5 | 2.5 | ? | ? |
| Apple powder | ? | 2.5 | ? | ? |
| Cranberry powder | ? | ? | ? | 2 |
| PVP K30 | ? | ? | ? | 1 |
| Starch | ? | ? | 5 | 1 |
| Talcum powder | ? | ? | 3 | ? |
| Dolomol | ? | ? | 2 | 1 |
| Glucose | ? | ? | ? | 2 |
| Microcrystalline cellulose | ? | ? | ? | 1 |
Embodiment 1
Prepare the pulvis of the health food of the develop immunitypty of the present embodiment:
(1) as shown in table 1, get safflower 5kg, coix seed 8kg, mushroom 10kg, Radix Angelicae Sinensis 5kg, Radix Codonopsis 10kg, fruit of Chinese wolfberry 15kg, barrenwort 10kg, seed of Chinese dodder 10kg, leek seed 8kg, ginkgo leaf 9kg, drop in extractor, extract 2 times, first time adds 8 times of water gagings (m/v), extract 2h, second time adds 6 times of water gagings (m/v), extracts 2h.Twice filtrate merges, and filtrate reduced pressure concentration (pressure is 0.3Mpa, and concentrated 5 times, filtrate is concentrated into relative density 1.15) in decompression concentrator obtains medicinal extract.Medicinal extract is put in reduced vacuum drying cupboard dry, and pressure is 98.5KPa, and baking temperature is 65 DEG C, and drying time is 2h, namely gets dry extract.
(2) above-mentioned dry cream is pulverized through pulverizer, cross 80 mesh sieves; Through equal increments method, (so-called equal increments refers to the component that the amount of component and the equivalent of getting a small amount of is large together with acesulfame potassium 0.03kg with the strawberry powder 5kg, the antierythrite 4.97kg that cross 80 mesh sieves, be placed in mixing machinery to mix simultaneously, the component adding the amount of same mixture equivalent larger mixes, times amount like this increases till adding the large component of whole amount, lower same) mix, be placed in three-dimensional mixer again to mix, then asepticize automated packaging equipment is adopted to pack, i.e. the pulvis of the health food of the develop immunitypty of obtained the present embodiment.
Embodiment 2
Prepare the granule of the health food of the develop immunitypty of the present embodiment:
(1) as shown in table 1, get safflower 8kg, coix seed 15kg, mushroom 10kg, Radix Angelicae Sinensis 5kg, Radix Codonopsis 8kg, fruit of Chinese wolfberry 10kg, barrenwort 10kg, seed of Chinese dodder 8kg, leek seed 8kg and ginkgo leaf 8kg, drop in extractor, extract 2 times, first time adds 8 times of water gagings (m/v), extract 2h, second time adds 6 times of water gagings (m/v), extracts 2h.Twice filtrate merges, and filtrate reduced pressure concentration (pressure is 0.3Mpa, and concentrated 5 times, filtrate is concentrated into relative density 1.18) in decompression concentrator obtains medicinal extract.
(2) above-mentioned concentrated medicinal extract and white granulated sugar 5kg, strawberry powder 2.5kg and apple powder 2.5kg are dropped in efficient wet granulator make softwood; wet granular is made through oscillating granulator 16 eye mesh screen; then wet granular is placed in drying box and carries out drying process; dried particle is after the whole grain of pelletizing machine; asepticize automated packaging equipment is adopted to pack, i.e. the granule of the health food of the develop immunitypty of obtained the present embodiment.
Embodiment 3
Prepare the hard capsule of the health food of the develop immunitypty of the present embodiment:
(1) as shown in table 1, get safflower 10kg, coix seed 10kg, mushroom 12kg, Radix Angelicae Sinensis 8kg, Radix Codonopsis 10kg, fruit of Chinese wolfberry 10kg, barrenwort 5kg, seed of Chinese dodder 5kg, leek seed 10kg, ginkgo leaf 10kg, drop in extractor, extract 2 times, first time adds 8 times of water gagings (m/v), extract 2h, second time adds 6 times of water gagings (m/v), extracts 2h.Twice filtrate merges, and filtrate reduced pressure concentration (pressure is 0.25Mpa, and concentrated 5 times, filtrate is concentrated into relative density 1.18) in decompression concentrator obtains medicinal extract.Medicinal extract is put in reduced vacuum drying cupboard dry, and pressure is 94.5KPa, and baking temperature is 70 DEG C, and drying time is 2h, namely gets dry extract.
(2) above-mentioned dry cream is pulverized through pulverizer, cross 80 mesh sieves; Mix with starch 5kg, talcum powder 3kg, the dolomol 2kg equal increments method of crossing 80 mesh sieves, be placed in three-dimensional motion mixer again to mix, then through Autocapsulefillingmachine filled capsules, polishing is carried out to populated capsule, namely obtains the hard capsule of the health food of the develop immunitypty of the present embodiment.
Embodiment 4
Prepare the tablet of the health food of the develop immunitypty of the present embodiment:
(1) as shown in table 1, get safflower 5kg, coix seed 10kg, mushroom 15kg, Radix Angelicae Sinensis 10kg, Radix Codonopsis 15kg, fruit of Chinese wolfberry 8kg, barrenwort 8kg, seed of Chinese dodder 9kg, leek seed 5kg, ginkgo leaf 5kg, drop in extractor, extract 2 times, first time adds 8 times of water gagings (m/v), extract 2h, second time adds 6 times of water gagings (m/v), extracts 2h.Twice filtrate merges, and filtrate reduced pressure concentration (pressure is 0.25Mpa, and concentrated 5 times, filtrate is concentrated into relative density 1.20) in decompression concentrator obtains medicinal extract.
(2) by above-mentioned medicinal extract and the Cranberry powder 2kg after pulverizing, starch 1kg, white granulated sugar 2kg, glucose 2kg, PVP K30 1kg and microcrystalline cellulose 1kg drops in efficient wet granulator and makes softwood, wet granular is made with oscillating granulator 16 eye mesh screen, then wet granular carries out drying process (be dried to pellet moisture and be less than 5%) at drying box, dried particle is through whole grain to 16 order of pelletizing machine, particle after whole grain and dolomol 1kg always mix 20min, dolomol is as lubricant, add in total mixed processing step, sticking when being to prevent compressing tablet, cause sliver, then high speed tablet press is adopted to carry out compressing tablet the particle mixed, the i.e. tablet of the health food of the develop immunitypty of obtained the present embodiment.
Measure of merit:
Carry out Safety and toxicology evaluation test and the test of animal function assessment for the hard capsule of embodiment 3 according to " health food inspection and assessment technical specification " (2003 editions), result is as follows:
1. acute toxicity test: its mouse oral acute toxicity LD
50> 21.5g/kg, belongs to actual nontoxic according to acute toxicity grading criteria health food of the present invention.
2.Ames test, micronucleus test and spermatic aberration test result are feminine gender, prove that health food of the present invention is without mutagenicity.
3.30 days feeding trials show the present invention have the body weight of health food to mouse of develop immunitypty, food utilization, latter stage hematology, blood biochemistry, latter stage dirty body when Histopathology index be showed no obvious harmful effect.
4. function assessment evaluation test:
(1) hard capsule of embodiment 3 body weight of mouse is increased, the impact of thymus gland/body weight ratio, spleen/body weight ratio, monocytes/macrophages carbonic clearance function
Embodiment 3 makes the hard capsule that specification is 300mg/ grain.The oral recommendation consumption of people is everyone (adult) every day 3 times, each 3.Adult's body weight calculates according to 60kg, and amounting to dosage is 0.045g/kg.bw.According to the oral recommendation consumption of people, if the basic, normal, high dosage component of sample be not 0.135,0.45,1.35g/kg.bw (recommend consumption respectively relative to people 3,10,30 times), and a negative control group is set, often organizes 12 mouse.The dilution of hard shell capsules purified water is mixed with high, medium and low dose concentration and carries out gavage, control group directly with purified water gavage, gavage amount be 0.4ml/ only, every day gavage once, continuous gavage 30 days.Found that, the body weight growth of mouse, thymus gland/body weight ratio, spleen/body weight ratio, monocytes/macrophages carbonic clearance function all have no significant effect.
(2) embodiment 3 hard capsule on mouse lymphocyte conversion capability to affect method the same, test result is as shown in table 1.
Table 1
Through statistical procedures, high dose group wherein has significant differences (P < 0.01) with comparing between control group, namely shows that product of the present invention has and promotes the lymphopoiesis of mouse, the effect of conversion capability.
(3) embodiment 3 hard capsule antagonist cellulation number to affect method the same, test result is as shown in table 2.
Table 2
Through statistical procedures, its antibody-producting cell number basic, normal, high dosage group with more all have significant difference (P < 0.05 between control group, P < 0.01), namely product of the present invention can increase mouse antibodies cellulation number.
(4) embodiment 3 hard capsule on mouse HD50 value (HC50) to affect method the same, test result is as shown in table 3.
Table 3
Through statistical procedures, its HD50 value (HC50) basic, normal, high dosage group with more all have significant difference (P < 0.05 between control group, P < 0.01), namely product of the present invention can improve the HD50 value (HC50) of mouse.
(5) embodiment 3 hard capsule on mouse delayed allergy to affect method the same, test result is as shown in table 4.
Table 4
Through statistical procedures, high, middle dosage group has very significant (P < 0.01) with comparing between control group, shows that product of the present invention has the effect of the delayed allergy promoting mouse.
(6) embodiment 3 hard capsule on NK cells in mice activity to affect method the same, test result is as shown in table 5.
Table 5
Through statistical procedures, its NK cytoactive compares between high dose group with control group significant differences (P < 0.01), namely shows that product of the present invention can improve NK cells in mice activity.
Claims (9)
1. there is a health food for develop immunitypty, it is characterized in that, be made up of the raw material of following parts by weight:
2. the health food with develop immunitypty according to claim 1, is characterized in that, described auxiliary material is at least one in Fruit powder, diluent, adhesive, lubricant, sweetener and flavoring essence.
3. the health food with develop immunitypty according to claim 2, is characterized in that, described Fruit powder is at least one in orange powder, strawberry powder, apple powder, blueberry powder, pomegranate powder, cherry powder and Cranberry powder; Described diluent is at least one in starch, Icing Sugar, dextrin, microcrystalline cellulose and inorganic salts; Described adhesive is at least one in starch slurry, sodium carboxymethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose and PVP K30; Described lubricant is at least one in dolomol, talcum powder and polyethylene glycol; Described sweetener is at least one in white granulated sugar, glucose, fructose, xylitol, sweet mellow wine, antierythrite, acesulfame potassium, Sucralose and Aspartame.
4. the health food with develop immunitypty according to claim 3, is characterized in that, is made up of the raw material of following parts by weight:
Described auxiliary material is made up of the component of following parts by weight:
5. the health food with develop immunitypty according to claim 4, is characterized in that, described health food is pulvis, granule, tablet and hard capsule.
6. the health food with develop immunitypty according to claim 5, is characterized in that, the preparation method of the pulvis of the health food of develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, wherein pressure is 0.2Mpa ~ 0.3Mpa, concentrated 4-5 doubly, filtrate is concentrated into relative density 1.15 ~ 1.20, obtains medicinal extract, and medicinal extract is put in reduced vacuum drying cupboard and is drying to obtain dry cream;
(2) above-mentioned dry cream is pulverized through pulverizer, cross 60-100 mesh sieve; Mix through equal increments method together to the auxiliary material of the above-mentioned corresponding parts by weight crossing 60-100 mesh sieve, then be placed in three-dimensional mixer and mix, then adopt asepticize automated packaging equipment to pack, i.e. the pulvis of the health food of obtained develop immunitypty.
7. the health food with develop immunitypty according to claim 5, is characterized in that, the preparation method of the granule of the health food of develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, and second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, and wherein pressure is 0.2Mpa ~ 0.3Mpa, and concentrated 4-5 doubly, filtrate is concentrated into relative density 1.15 ~ 1.20, obtains medicinal extract;
(2) above-mentioned concentrated medicinal extract is dropped in efficient wet granulator to the auxiliary material of above-mentioned corresponding parts by weight make softwood; wet granular is made through swing granule; then wet granular is placed in drying box and carries out drying process; dried particle is after the whole grain of pelletizing machine; asepticize automated packaging equipment is adopted to pack, i.e. the granule of the health food of obtained develop immunitypty.
8. the health food with develop immunitypty according to claim 5, is characterized in that, the preparation method of the hard capsule of the health food of develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, wherein pressure is 0.2Mpa ~ 0.3Mpa, doubly, obtain medicinal extract, filtrate is concentrated into relative density 1.15 ~ 1.20 to concentrated 4-5, medicinal extract is put in reduced vacuum drying cupboard dry, namely gets dry extract;
(2) above-mentioned dry cream is pulverized through pulverizer, cross 60-100 mesh sieve; Mix to the auxiliary material equal increments method of the above-mentioned corresponding parts by weight crossing 60-100 mesh sieve, be placed in three-dimensional motion mixer again to mix, then through Autocapsulefillingmachine filled capsules, polishing is carried out to populated capsule, the hard capsule of the health food of the immunity that is namely enhanced.
9. the health food with develop immunitypty according to claim 5, is characterized in that, the preparation method of the tablet of the health food of develop immunitypty is:
(1) safflower, coix seed, mushroom, Radix Angelicae Sinensis, Radix Codonopsis, the fruit of Chinese wolfberry, barrenwort, the seed of Chinese dodder, leek seed and ginkgo leaf is taken according to as above parts by weight, drop in extractor, extract 2 times, first time adds 7-9 times amount water extraction and gets 1-3h, and second time adds 5-7 times amount water extraction and gets 1-3h, twice filtrate is merged, filtrate is reduced pressure concentration in decompression concentrator, and wherein pressure is 0.2Mpa ~ 0.3Mpa, and concentrated 4-5 doubly, filtrate is concentrated into relative density 1.15 ~ 1.20, obtains medicinal extract;
(2) by above-mentioned medicinal extract to pulverize after above-mentioned corresponding parts by weight auxiliary material except lubricant drop in efficient wet granulator and make softwood; wet granular is obtained with oscillating granulator; then wet granular carries out drying process at drying box; dried particle is through the whole grain of pelletizing machine; particle after whole grain and lubricant always mix; the particle mixed adopts high speed tablet press to carry out compressing tablet, i.e. the tablet of the health food of obtained develop immunitypty.
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| CN107668705A (en) * | 2017-10-11 | 2018-02-09 | 无限极（中国）有限公司 | A kind of pulvis with strengthen immunity function and preparation method thereof |
| CN110585008A (en) * | 2019-08-07 | 2019-12-20 | 北京长峰金鼎科技有限公司 | Method for preparing granules by wet granulation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105266155A (en) * | 2015-11-20 | 2016-01-27 | 延边利孚生物科技有限公司 | Composition used for improving sub-health of brain and preparing method thereof |
| CN106036802A (en) * | 2016-05-24 | 2016-10-26 | 江苏江大源生态生物科技股份有限公司 | Selenium-enriched grifola frondosa capsules having efficacy of enhancing immunity and preparation method of selenium-enriched grifola frondosa capsules |
| CN107668705A (en) * | 2017-10-11 | 2018-02-09 | 无限极（中国）有限公司 | A kind of pulvis with strengthen immunity function and preparation method thereof |
| US10813961B2 (en) | 2017-10-11 | 2020-10-27 | Infinitus (China) Company Ltd. | Powder formulation having a function of enhancing immunity and method for preparing the same |
| CN110585008A (en) * | 2019-08-07 | 2019-12-20 | 北京长峰金鼎科技有限公司 | Method for preparing granules by wet granulation method |
| CN110585008B (en) * | 2019-08-07 | 2022-05-03 | 北京长峰金鼎科技有限公司 | Method for preparing granules by wet granulation method |
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