CN103859406B - Immunity-improving colla corii asini and jujube capsule - Google Patents

Immunity-improving colla corii asini and jujube capsule Download PDF

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CN103859406B
CN103859406B CN201410103758.8A CN201410103758A CN103859406B CN 103859406 B CN103859406 B CN 103859406B CN 201410103758 A CN201410103758 A CN 201410103758A CN 103859406 B CN103859406 B CN 103859406B
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capsule
powder
donkey
date
extract powder
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CN103859406A (en
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王翠莲
秦怀国
周爱霞
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Huarun Shuanghe Pharmaceutical (Ji'nan) Co., Ltd. Limin
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Jinan Limin Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention discloses an immunity-improving colla corii asini and jujube capsule which is prepared from the following raw materials in parts by weight: 25-30 parts of colla corii asini powder, 25-30 parts of jujube extract powder, 1-2 parts of black sesame powder, 3-5 parts of corn pollen, 0.5-1.0 part of grape seed extract powder and 20-25 parts of Chinese herbal medicine extract powder, wherein the Chinese herbal medicine extract powder is prepared from the following raw materials: ginseng, sea-buckthorn, yams, sealwort, the fruit of Chinese wolfberry, wild jujube seeds, lilies, lotus seeds, peach kernels, hawthorn, fructus cannabis, fingered citron, rose flowers and liquorice. An animal function test proves that the colla corii asini and jujube capsule has a health-care function of improving immunity.

Description

A kind of donkey-hide gelatin date capsule that strengthens immunity
Technical field
The present invention relates to a kind of donkey-hide gelatin date capsule that strengthens immunity, belong to health product technology field.
Background technology
Immunity is the defense mechanism of human body self, is human body identification and any foreign matter (virus, bacterium etc.) of eliminating external intrusion; Process the ability of self cell and identification and processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, sex change.Modern immunology thinks, immunity is human body identification and the physiological reaction of getting rid of " dissident ".
Life has two stages that immunocompetence is low, i.e. children's stage and old stage.Children's immune system is not yet ripe, and function is unsound, hypoimmunity; And old functions of biological organs fails, obtains nutritional capacity decline, immune organ atrophy decline gradually in addition, causes immunity degradation.Adult's stress, malnutrition, shortage motion or do not have enough sleep, abuse of alcohol and smoking etc., all can Immunosuppression system, reduces immunity of organisms.Other factors as, noxious material, some drugs, radiotherapy and excessive antibiotic in environment also all can Immunosuppression systems.
The performances such as the crowd of hypoimmunity generally has a delicate constitution, malnutrition, listlessness, fatigue and weak, appetite reduction, sleep-disorder, sick, have an injection and take medicine the normal potluck that just gets married.Each sickly all will could recover for a long time, and usually outbreak repeatedly.If things go on like this can cause health and intelligence development bad, also easily bring out major disease.Therefore, need to strengthen immunity by external food or health products.Food strengthens immunity poor effect.
Summary of the invention
The present invention has overcome above-mentioned the deficiencies in the prior art, and a kind of donkey-hide gelatin date capsule that strengthens immunity is provided.The present invention, taking multiple materials such as donkey-hide gelatin powder, Fructus Jujubae extracts as major ingredient, adds starch supplementary material, makes the capsule preparations that is suitable for taking, and proves through animal function test, has the health care that strengthens immunity.
Technical scheme of the present invention is: a kind of donkey-hide gelatin date capsule that strengthens immunity, it is characterized in that, raw material and the weight portion thereof of making its active ingredient are: donkey-hide gelatin powder 25-30, Fructus Jujubae extract powder 25-30, black sesame powder 1-2, zasiokaurin 3-5, grape seed extract powder 0.5-1.0, Chinese herbal medicine extract powder 20-25.Above-mentioned raw materials was 80 mesh sieves.
Said herbal medicine extract powder is made up of the bulk drug of following weight parts: ginseng 20-25, sea-buckthorn 18-22, Chinese yam 15-20, sealwort 15-20, fruit of Chinese wolfberry 12-18, spina date seed 15-20, lily 10-15, lotus seeds 10-15, peach kernel 15-20, hawthorn 25-30, fructus cannabis 10-15, Buddha's hand 10-15, rose 10-15, Radix Glycyrrhizae 3-8.Above-mentioned raw materials liquid medicine is decocted, through concentrate drying (to Han Shui Liang≤5%), ground to form the extract powder of 80 mesh sieves.
Wherein the polyoses content of Fructus Jujubae extract is 20-30%, procyanidin content >=50% in grape seed extract powder.
Above-mentioned donkey-hide gelatin date capsule, auxiliary material adopts starch, meter in mass ratio, major ingredient: auxiliary material=6-7:3-4.
Production technology:
(1) mix: above-mentioned raw materials and supplementary product starch are placed in to mixer mixing 20-40min, mix, obtain mixed powder;
(2) softwood processed: by the ethanol (food stage) that adds 90% in mixed powder, stir 10-20min, softwood processed, obtains softwood;
(3) granulate: softwood 26 mesh sieves are granulated, obtain wet granular;
(4) dry: wet granular to be dried, at temperature 48-52 DEG C, to be dried to water content≤5%;
(5) whole grain: cross the whole grain of 26 mesh sieves, obtain dry particle;
(6) filled capsules: dry particle filling is packed in capsulae vacuus into every heavy 0.5g/ grain, capsule after must filling.
Instructions of taking:
Suitable crowd: immunocompromised person, is unsuitable for children, pregnant woman and wet nurse and takes.
Amount and eating method: every day 2 times, each 4; Oral.
Specification: 0.5g/ grain.
Shelf-life: 24 months.
Storage practice: deposit shady and cool, dry, ventilation.
The pharmacological action of each raw material:
Donkey-hide gelatin: sweet, flat.Return lung, liver, kidney channel.Function with cure mainly: the enriching yin of enriching blood, moisturize, hemostasis.Sallow for the deficiency of blood, dizzy palpitaition, flesh impotence is unable, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough, the labor spitting of blood of coughing, haematemesis hematuria, the uterine bleeding of having blood in stool, vaginal bleeding during pregnancy.Research Literature shows: donkey-hide gelatin main component is polypeptide, several amino acids, metallic element and dermatan sulfate, the bionic acid etc. that proteolysis produces.
Date: sweet, temperature.Return spleen, stomach, the heart channel of Hang-Shaoyin.Function with cure mainly: tonifying middle-Jiao and Qi, nourishing blood and tranquilization.Few for insufficiency of the spleen food, weak loose stool, hysteria of womam.
Ginseng: sweet, micro-hardship, tepor.Return spleen, lung, the heart, kidney channel.Function with cure mainly: reinforce vital energy, multiple arteries and veins is admittedly de-, reinforces the spleen to benefit the lung, and promotes the production of body fluid and nourishes blood, the intelligence development of calming the nerves.De-for the empty wish of body, the cold weak pulse of limb, insufficiency of the spleen food is few, and the deficiency syndrome of the lung is breathed with cough, and Tianjin wound is thirsty, and interior heat is quenched one's thirst, deficiency of qi and blood, prolonged illness is empty wins, palpitation with fear insomnia, impotence palace is cold.
Sea-buckthorn: sour, puckery, temperature.Return spleen, stomach, lung, the heart channel of Hang-Shaoyin.Function with cure mainly: reinforcing spleen to promote digestion, cough-relieving apophlegmatic.Promoting blood circulation to remove blood stasis.Few for insufficiency of the spleen food, dyspeptic abdominalgia, coughing with a lot of sputum, chest impediment and cardialgia, hemostasis is through closing, and falls that to flutter the stasis of blood swollen.
Chinese yam: sweet, flat.Return spleen, lung, kidney channel.Tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.Few for insufficiency of the spleen food, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.
Sealwort: sweet, flat.Return spleen, lung, kidney channel.Function with cure mainly: boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry food is few, deficiency syndrome of the lung cough caused by dryness, the labor hemoptysis of coughing, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, interior heat is quenched one's thirst.
The fruit of Chinese wolfberry: sweet, flat.Return liver, kidney channel.Effect: nourishing liver and kidney, benefiting shrewd head.Cure mainly: lose for consumptive disease essence.Soreness of waist and knee joint, dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear.
Spina date seed: sweet, sour, flat.Return liver, courage, the heart channel of Hang-Shaoyin.Function with cure mainly: the tonifying liver that nourishes heart, antitoxic heart-soothing and sedative, arrest sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hidrosis of body, Tianjin wound is thirsty.
Lily: sweet, cold.The thoughts of returning home, lung channel.Effect: Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.Cure mainly: for deficiency of Yin chronic cough, blood-stained sputum, dysphoria palpitation with fear, insomnia and dreamful sleep, absent-minded.
Lotus seeds: sweet, puckery, flat.Return spleen, kidney, the heart channel of Hang-Shaoyin.Function with cure mainly: tonifying spleen antidiarrheal, only band, the puckery essence of kidney-nourishing, mental-tranquilization.For splenasthenic diarrhea, under band, seminal emission, palpitation and insomnia.
Peach kernel: bitter, sweet, flat.The thoughts of returning home, liver, large intestine channel.Function with cure mainly: promoting blood circulation, relax bowel, relieving cough and asthma.Be used for through closing dysmenorrhoea lung carbuncle acute appendicitis, injury from falling down, the dry constipation of intestines, cough and asthma.
Hawthorn: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Function with cure mainly: food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of faling apart, changes turbid lipopenicillinase.For carnivorous stagnant, gastral cavilty turgor, rushes down dysentery stomachache, and hemostasis is through closing, postpartum stasis blocking, trusted subordinate's shouting pain, chest impediment and cardialgia, hernia pain, hyperlipidemia.
Fructus cannabis: sweet, flat.Return spleen, stomach, large intestine channel.Effect and application: relax bowel.For the dry constipation of intestines, moisturize, desinsection: cannot not deal with rawly; Sore leprosy.
Buddha's hand: pungent, bitter, sour, temperature.Return liver, spleen, stomach, lung channel.Function with cure mainly: dispersing stagnated hepatoqi, and stomach and alleviating pain, eliminating dampness and eliminating phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty ruffian is full, the few vomiting of food, coughing with a lot of sputum.
Rose: sweet, micro-hardship, temperature.Return liver, the spleen channel.Function with cure mainly: promoting qi circulation and removing obstruction in the collateral, and blood, pain relieving.For stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, eat the evil of vomitting less, menstruation is not withered, and falls and flutters the pain of injury.
Radix Glycyrrhizae: sweet, flat.The thoughts of returning home, lung, spleen, stomach warp.Function with cure mainly: invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Semen sesami nigrum: sweet, flat.Return liver, kidney, large intestine channel.Function with cure mainly: filling liver kidney, benefiting essence-blood, ease constipation is dry.For blood and essence asthenia, dizzy, Hiccough and deaf, poliosis, post disease alopecia, the dry constipation of intestines.
Zasiokaurin: contain 18 seed amino acids in popped rice powder, free aminoacid content that can be directly absorbed by the body is up to 23%, and its protein content is 22%～25%, also contains sugar and organic acid etc.
Grape seed extract: can effectively remove unnecessary free radical in human body, there is the superpower effect that delays senility and strengthen immunity.Anti-oxidant, antiallergy, antifatigue are built up health, are improved sub-health state and delay senility, improve the symptom such as irritated irritability, dizzy weak, failure of memory.
The present invention is from theory of traditional Chinese medical science, with above-mentioned medicament composing prescription strengthening vital QI to eliminate pathogenic factors, wherein nourish blood with donkey-hide gelatin, date and ginseng qi-tonifying, with Buddha's hand and the rose Xie Yu that regulates the flow of vital energy, with spina date seed, lily, lotus seeds and ginseng clearing away the heart fire and tranquillizing, with peach kernel, sea-buckthorn and hawthorn promoting blood circulation to remove blood stasis, with sealwort, the fruit of Chinese wolfberry and Chinese yam nourishing liver, invigorating kidney, help digestion with sea-buckthorn, Chinese yam and hawthorn strengthening spleen and nourishing stomach, relax bowel with fructus cannabis and peach kernel, Radix Glycyrrhizae coordinating the drug actions of a prescription.Each Chinese medicine acting in conjunction, thus human body each side function is recovered fast, thus strengthen the immunity of human body.
From chemical terms, in above-mentioned Chinese medicine, contain the polysaccharose substance of high level as date polysaccharide, panaxan, Fructus Hippophae polysaccharide, LBP-X, peach kernel polysaccharide, lily polysaccharide, spina date seed polysaccharide, Buddha's hand polysaccharide etc.In donkey-hide gelatin, date, sea-buckthorn, the fruit of Chinese wolfberry, Chinese yam, zasiokaurin etc., contain the materials such as a large amount of amino acid simultaneously.Hawthorn contains a large amount of Vcs and organic acid substance.In grape seed extract, contain vitamin E and OPC.These materials contribute to strengthen the resistance of human body.
The invention has the beneficial effects as follows: raw material of the present invention all adopts the material of medicine-food two-purpose, and human body is had no side effect.This donkey-hide gelatin date capsule proves to have the health care that strengthens immunity through animal function test.
Further illustrate its beneficial effect below in conjunction with function test.
1. material
1.1 experimental animals: 48 of the female secondary mouse of clean type Kunming kind, body weight 18-22 gram, is divided into 4 groups at random by body weight, 12 every group.
1.2 dosage groupings and given the test agent give the time: donkey-hide gelatin date capsule 4 grams/people of (formula is shown in embodiment 1) recommended amounts of the present invention (60kg) day (66.6mg/kgBW).Three dosage groups and a blank group are established in experiment, and taking 5 times of human body recommended amounts as low dose group (333mg/kgBW), 10 times is middle dosage group (666mg/kgBW), and 30 times is high dose group (2000mg/kgBW).The preparation of tested material water, mouse stomach volume is that 0.2ml/10 gram of mouse is heavy, it is 30 days that tested material gives the time.Blank group is filled with distilled water.
2. experimental technique
Carry out functional evaluation by internal organs/weight ratio pH-value determination pH, lymphopoiesis ability OD difference, swelling degree of the paw, HD50 value (HC50) and the clearance test of mouse carbon.Test method is referring to the general Ministry of Public Health " inspection of donkey-hide gelatin date capsule and assessment technique specification " (2003 editions) function assessment evaluation test method-enhancing immunity function method of inspection.
3. result of the test
3.1 impacts on normal mouse thymus, spleen weight
The impact of table 1 donkey-hide gelatin date of the present invention capsule on mouse thymus, spleen weight
Note: * has significant difference (P ﹤ 0.05) compared with control group, and * * has compared with significant difference (P ﹤ 0.01) compared with blank group
As can be seen from Table 1: per os gives the donkey-hide gelatin date capsule of the present invention 30 days of the each dosage of mouse, and compared with control group, each dosage group thymus gland, spleen/body weight ratio all have no significant effect (P ﹥ 0.05).
2, the impact on mouse cell immunity
The impact of table 2 donkey-hide gelatin date of the present invention capsule on immune function of mice
Note: * has significant difference (P ﹤ 0.05) compared with control group, and * * has compared with significant difference (P ﹤ 0.01) compared with blank group
As can be seen from Table 2: per os gives the donkey-hide gelatin date capsule of the present invention 30 days of the each dosage of mouse, and middle dosage group can strengthen mouse lymphocyte multiplication capacity (P ﹤ 0.05), and high dose group can obviously strengthen mouse lymphocyte multiplication capacity (P ﹤ 0.01); Middle dosage group can strengthen mouse swelling degree of the paw (P ﹤ 0.05), and high dose group can obviously strengthen mouse swelling degree of the paw (P ﹤ 0.01).
3, the impact on mouse humoral immune
The impact of table 3 donkey-hide gelatin date of the present invention capsule on mouse humoral immune
Note: * has significant difference (P ﹤ 0.05) compared with control group, and * * has compared with significant difference (P ﹤ 0.01) compared with blank group
As can be seen from Table 3: per os gives the donkey-hide gelatin date capsule of the present invention 30 days of the each dosage of mouse, and compared with control group, half hemolytic dose HC50 does not have significant difference.
4, the capacity of mouse monokaryon one macrophage carbon being cleaned up
The impact of the ability that table 4 donkey-hide gelatin date of the present invention capsule is cleaned up mouse monokaryon one macrophage carbon
Group Phagocytic index (a)
Blank group 4.11±1.82
Low dose group 4.93±1.71
Middle dosage group 5.85±1.35*
High dose group 6.22±1.02**
Note: * has significant difference (P ﹤ 0.05) compared with control group, and * * has compared with significant difference (P ﹤ 0.01) compared with blank group
Result of the test shows: per os gives the donkey-hide gelatin date capsule of the present invention 30 days of the each dosage of mouse, middle dosage group can improve the ability (P ﹤ 0.05) that mouse monokaryon one macrophage carbon is cleaned up, and high dose group can obviously improve the ability (P ﹤ 0.01) that mouse monokaryon one macrophage carbon is cleaned up.
To sum up, donkey-hide gelatin date capsule of the present invention can obviously strengthen mouse lymphocyte multiplication capacity, swelling degree of the paw and mouse carbon and clean up ability, fully shows that it has the function that strengthens immunity.
Detailed description of the invention
Embodiment 1:
1, major ingredient: donkey-hide gelatin powder 30kg, Fructus Jujubae extract powder 25kg, black sesame powder 1kg, zasiokaurin 5kg, grape seed extract powder 0.8kg, Chinese herbal medicine extract powder 20kg.Above-mentioned raw materials was the powder of 80 mesh sieves.Wherein the polyoses content of Fructus Jujubae extract is 30%, and in grape seed extract powder, procyanidin content is 50%.
Said herbal medicine extract powder is made up of the raw material of following weight parts: ginseng 25, sea-buckthorn 20, Chinese yam 16, sealwort 16, the fruit of Chinese wolfberry 15, spina date seed 16, lily 12, lotus seeds 12, peach kernel 16, hawthorn 28, fructus cannabis 12, Buddha's hand 12, rose 12, Radix Glycyrrhizae 5.Add the decocting of 1.5 times of its quality to boil 50 minutes above-mentioned raw materials, filter residue adds the decocting of 1 times of its quality to boil again 40 minutes; Merge 2 times decoction liquor, through concentrate drying (to Han Shui Liang≤5%), ground to form the extract powder of 80 mesh sieves.
2, auxiliary material: starch: 44.0kg.
3, production technology:
(1) mix: above-mentioned raw materials and supplementary product starch are placed in to trough-type mixture machine mixing 30min, mix, obtain mixed powder; Trough-type mixture machine technical parameter: slot type S type list slurry, 105 ° of mixing channel flip angles, main engine power 4KW, upset power 0.75KW;
(2) softwood processed: by the ethanol (food stage) that adds 90% in mixed powder, stir 15min, softwood processed, obtains softwood; Ethanol meets the related request of GB10343-2008 " edible alcohol ".
(3) granulate: softwood 26 mesh sieves are granulated, obtain wet granular;
(4) dry: wet granular is dried, and temperature 50 C is to water content≤5%.
(5) whole grain: cross the whole grain of 26 mesh sieves, obtain dry particle;
(6) filled capsules: adopt Autocapsulefillingmachine that dry particle filling is packed in capsulae vacuus, adjust heavy 0.5g/ grain, capsule after must filling for every.The content uniformity that should note monitoring every granule product during filling, is controlled in disparity range.Capsule shells meets the regulation of " gelatin Capsules " in " People's Republic of China (PRC) " 2010 editions two.
Autocapsulefillingmachine technical parameter: machine net weight 800kg, power requirement 380V, frequency 50Hz, vacuum-0.02--0.05mPa, operating noise <80dB.
(7) polishing: the capsule after filling is carried out to polishing, make capsule surface bright and clean.
(8) select: reject substandard product.Manually defective capsule is selected, rejected the defective works such as flat capsule, broken capsule, ghost, leakage powder.Operator is with mouth mask and gloves.After manually picking, entering packing shop packs.
(9) inner packing: the oral stable medicinal polythene bottle with high density that adopts quality standard to meet YBB00122002 is packaging material bottlings, 60/bottle, sends clean area;
(10) external packing: vanning, obtains finished product.Carton meets the regulation of GB/T6543-2008 " single and double corrugated boxes for transport packages ".The assay of product is as shown in table 5 below.
Table 5 examination and test of products result
Remarks: pathogenic bacteria comprise: salmonella, Shigella, staphylococcus aureus, hemolytic streptococcus.
Instructions of taking:
Suitable crowd: immunocompromised person, is unsuitable for children, pregnant woman and wet nurse and takes.
Amount and eating method: every day 2 times, each 4; Oral.
Specification: 0.5g/ grain.
Shelf-life: 24 months.
Storage practice: deposit shady and cool, dry, ventilation.
Embodiment 2
1, major ingredient: donkey-hide gelatin powder 30kg, Fructus Jujubae extract powder 30kg, black sesame powder 1.5kg, zasiokaurin 4.5kg, grape seed extract powder 0.5kg, Chinese herbal medicine extract powder 22kg.Above-mentioned raw materials was the powder of 80 mesh sieves.Wherein the polyoses content of Fructus Jujubae extract is 20%, and in grape seed extract powder, procyanidin content is 70%.
Said herbal medicine extract powder is made up of the raw material of following weight parts: ginseng 20, sea-buckthorn 18, Chinese yam 15, sealwort 15, the fruit of Chinese wolfberry 12, spina date seed 15, lily 10, lotus seeds 10, peach kernel 15, hawthorn 25, fructus cannabis 10, Buddha's hand 10, rose 10, Radix Glycyrrhizae 5.Add the decocting of 2 times of its quality to boil 40 minutes above-mentioned raw materials, filter residue adds the decocting of 1 times of its quality to boil to decoct 30 minutes more again; Merge 2 times decoction liquor, through concentrate drying (to Han Shui Liang≤5%), ground to form the extract powder of 80 mesh sieves.
2, auxiliary material: starch: 40.0kg.
3, production technology is with embodiment 1.
Embodiment 3
1, major ingredient: donkey-hide gelatin powder 30kg, Fructus Jujubae extract powder 28kg, black sesame powder 2kg, zasiokaurin 3kg, grape seed extract powder 1.0kg, Chinese herbal medicine extract powder 25kg.Above-mentioned raw materials was the powder of 80 mesh sieves.Wherein the polyoses content of Fructus Jujubae extract is 25%, and in grape seed extract powder, procyanidin content is 50%.
Said herbal medicine extract powder is made up of the raw material of following weight parts: ginseng 25, sea-buckthorn 22, Chinese yam 20, sealwort 20, the fruit of Chinese wolfberry 18, spina date seed 20, lily 15, lotus seeds 15, peach kernel 20, hawthorn 30, fructus cannabis 15, Buddha's hand 15, rose 15, Radix Glycyrrhizae 5.Add the decocting of 1.5 times of its quality to boil 50 minutes above-mentioned raw materials, filter residue adds the decocting of 1 times of its quality to boil again 40 minutes; Merge 2 times decoction liquor, through concentrate drying (to Han Shui Liang≤5%), ground to form the extract powder of 80 mesh sieves.
2, auxiliary material: starch: 58.0kg.
3, production technology is with embodiment 1.

Claims (5)

1. one kind strengthens the donkey-hide gelatin date capsule of immunity, it is characterized in that, raw material and the weight portion thereof of making its active ingredient are: donkey-hide gelatin powder 25-30, Fructus Jujubae extract powder 25-30, black sesame powder 1-2, zasiokaurin 3-5, grape seed extract powder 0.5-1.0, Chinese herbal medicine extract powder 20-25;
Described Chinese herbal medicine extract powder is made up of the bulk drug of following weight parts: ginseng 20-25, sea-buckthorn 18-22, Chinese yam 15-20, sealwort 15-20, fruit of Chinese wolfberry 12-18, spina date seed 15-20, lily 10-15, lotus seeds 10-15, peach kernel 15-20, hawthorn 25-30, fructus cannabis 10-15, Buddha's hand 10-15, rose 10-15, Radix Glycyrrhizae 3-8; Above-mentioned raw materials liquid medicine is decocted, through concentrate drying, after grinding, obtain Chinese herbal medicine extract powder;
The polyoses content of described Fructus Jujubae extract is 20-30wt%.
2. a kind of donkey-hide gelatin date capsule that strengthens immunity as claimed in claim 1, is characterized in that procyanidin content >=50wt% in described grape seed extract powder.
3. a kind of donkey-hide gelatin date capsule that strengthens immunity as claimed in claim 1, is characterized in that, described raw material was 80 mesh sieves.
4. a kind of donkey-hide gelatin date capsule that strengthens immunity as described in any one in claim 1-3, is characterized in that, the auxiliary material of described donkey-hide gelatin date capsule is starch, meter in mass ratio, the raw material total amount of claim 1: supplementary product starch=6-7:3-4.
5. the production technology of a kind of donkey-hide gelatin date capsule that strengthens immunity claimed in claim 4, is characterized in that,
(1) mix: raw material and supplementary product starch are placed in to mixer mixing 20-40min, mix, obtain mixed powder;
(2) softwood processed: by the ethanol that adds 90% in mixed powder, stir 10-20min, softwood processed, obtains softwood;
(3) granulate: softwood 26 mesh sieves are granulated, obtain wet granular;
(4) dry: wet granular to be dried, at temperature 48-52 DEG C, to be dried to water content≤5%;
(5) whole grain: cross the whole grain of 26 mesh sieves, obtain dry particle;
(6) filled capsules: dry particle filling is packed in capsulae vacuus, obtain capsule preparations.
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CN105381229A (en) * 2015-12-29 2016-03-09 美可高特羊乳有限公司 Composition with efficacy of boosting immunity and preparation method of composition
CN107006840A (en) * 2017-02-23 2017-08-04 北京众康生物科技有限公司 A kind of Saussurea involucrata culture capsule and preparation method thereof
CN109007510A (en) * 2018-07-25 2018-12-18 北京科泰健业企业管理有限公司 A kind of fingered citron donkey-hide gelatin draft solid beverage

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