CN105998733A - 一种梨花百合蜜膏的制备方法 - Google Patents
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Abstract
本发明公开了一种梨花百合蜜膏的制备方法，该产品中草药原料组成为百合40～60份、梨花20～30份、黄芪10～15份、厚朴8～12份、麦冬10～15份、茯苓15～20份、熟地10～13份、当归8～12份、紫苑10～15份、枸杞10～16份、石斛10～18份、五味子5～10份、远志5～10份、甘草10～15份、甜叶菊10～15份、蜂蜜1000份，采用“超声波辅助浸提+蒸馏挥发油+水煎+醇提”工艺制备。该产品具有养心补肺预防咳嗽功效好、安全无副作用、饮用方便等优势。
Description
技术领域
本发明涉及一种梨花百合蜜膏的制备方法，特别是一种以梨花、百合及其他植物中草药为原料制成的梨花百合蜜膏，属保健领域。
背景技术
营养是人体生命的源泉，各类咳嗽的营养食疗是以营养学为主导、功能学为次，对食药同源原料进行科学开发，对各类咳嗽患者以食药同源为主的营养食疗养生健体方法的加入，给足人体各器官修复所需的营养物质，增加营养，补充体力，顺势激发和增强人体自身修复的能力，受损的器官通过细胞的不断新陈代谢和自我修复加快咳嗽患者康复。基于上述认知，随着我国雾霾等恶劣生态环境的不断出现，开发具有养心补肺、防治咳嗽和哮喘等功效保健食疗产品成为当务之急。目前市场上缺少高效、绿色的该类保健食品。
发明内容
为克服现有产品技术的不足，本发明的目的在于提供一种梨花百合蜜膏的制备方法。
本发明上述目的是通过以下技术方案予以实现的：
本发明提供一种梨花百合蜜膏的制备方法，其特征在于中草药原料及质量配比为：百合40～60份、梨花20～30份、黄芪10～15份、厚朴8～12份、麦冬10～15份、茯苓15～20份、熟地10～13份、当归8～12份、紫苑10～15份、枸杞10～16份、石斛10～18份、五味子5～10份、远志5～10份、甘草10～15份、甜叶菊10～15份、蜂蜜1000份。
本发明的优选技术方案是：一种梨花百合蜜膏的制备方法，其特征在于：其中药原料及质量配比为：百合50份、梨花25份、黄芪13份、厚朴12份、麦冬12份、茯苓16份、熟地12份、当归10份、紫苑14份、枸杞15份、石斛15份、五味子7份、远志7份、甘草12份、甜叶菊13份、蜂蜜1000份。
本发明提供一种梨花百合蜜膏的制备方法，其特征在于包括以下步骤：
（1）分拣称量：将所用中草药分拣，去除杂质等，按照上述比例称重；
（2）原料预处理：根据原料特性不同分别进行原料预处理：
①将百合、梨花、黄芪、厚朴、麦冬、茯苓、当归、熟地、紫苑、石斛、五味子、远志、甘草、甜叶菊混合后进行粉碎处理，过40目筛；
②向枸杞中加入2～3倍纯净水，打浆，然后加入1～2%果胶酶，在40～50℃条件下酶解10～20min；
（3）超声波辅助酶解：原料混合后加入原料质量比3～5倍纯净水，然后加入原料质量比2～3%纤维素酶、1～2%非淀粉多糖酶，在超声波辅助条件下酶解30～60min，酶解温度控制在40～50℃；
（4）离心：离心分离浸提液和中药草残渣；
（5）蒸馏：向中草药残渣中加入3～5倍量的纯净水，收集挥发油8～10h，挥发油单独收集放置，水溶液过滤，与浸提液合并；
（6）挥发油乳化：将收集的挥发油中加入1.5～2.0%的助溶剂吐温-80，加热乳化；
（7）水煎：将蒸馏后的中草药残渣中加入2～3倍量的水，煎煮3次，每次1.5～2h，水煎液与浸提液合并；
（8）减压浓缩：将合并后的水溶液浓缩至1g/ml的清膏，放冷；
（9）醇沉：向清膏中加入95%的乙醇使含醇量达到60～70%，4℃条件下放置48h以上
（10）醇提：向水煎后的中草药残渣中加入4～6倍量的50%乙醇，加热提取2次，提取时间1～1.5h；
（11）合并抽滤：将醇沉后的液体与醇提液合并抽滤；
（12）减压回收：将抽滤液进行减压回收乙醇至无醇味；
（13）混合：趁热向浓缩液中加入蜂蜜，搅拌均匀；
（14）均质：将混合后的物料进行均质处理；
（15）定容分装：将均质后的蜜膏定容、分装即得成品。
本发明提供一种梨花百合蜜膏的制备方法，其优势在于：一是在传统中医理论和实践指导下精选药方，科学配伍百合、梨花和多种中草药，药物组分经辨证配伍，应用我国传统医学“温经通络、活血化瘀”的医疗精髓，从调节引发咳嗽的肺、心、肝、脾等各类脏器的功能入手，调整体内气血平衡，促进体内五脏六腑的新陈代谢和正常功能，使其“气充百脉、活血去淤、养心补肺、调节肾脾、益气生津、润肺清咳”；二是在梨花百合蜜膏的制备过程中采用“超声波辅助浸提+蒸馏挥发油+水煎+醇提”的工艺，充分糅合中草药中的的功能活性成分，提高保健效果；三是梨花百合蜜膏安全无副作用，饮用方便。
本发明提供一种梨花百合蜜膏的制备方法，通过动物试验进行梨花百合蜜膏的毒理学试验及安全性评价。小鼠急性经口毒性试验结果表明，本梨花百合蜜膏对小鼠急性经口最大耐受剂量大于高剂量组75mg/kg·bw； 遗传毒性试验小鼠骨髓细胞微核试验和小鼠精子畸形试验两项试验结果均为阴性，表明该梨花百合蜜膏无致突变作用；由大鼠30d喂养试验可知，大鼠体征行为正常、体态健康、血液及血液生化指标也无异常变化，因此75mg/kg·bw的剂量（人体推荐量的150倍）属于安全剂量；遗传毒性试验和大鼠30d喂养试验结果均为阴性，因此确定本保健饮料属无毒类食品，人可以安全放心食用。
本发明提供一种梨花百合蜜膏的制备方法，不同的中草药性味各异，功效存在着巨大的差异，不同的中草药组合后存在复杂的相互作用关系，且中草药之间的配比比较密切，不同配比也将使君臣佐使关系发生实质性的变化，从而使复合中草药的关系发生实质性改变。本申请通过百合、梨花、黄芪、厚朴、麦冬、茯苓、熟地、当归、紫苑、枸杞、石斛、五味子、远志、甘草、甜叶菊等中草药彼此间存在复杂的相互作用关系，合理配比，取得了预料不到的技术效果，使梨花百合蜜膏的关系发生实质性改变。根据《保健食品功能学评价程序和检验方法》对本申请产品进行了功能性评价，利用小鼠试验测定梨花百合蜜膏对咳嗽的影响，结果表明饲喂本发明产品小鼠咳嗽潜伏期延长35.76%、咳嗽次数减少74.32%，与对照组相比差异显著(P<0.01)；此外，试验结果表明，改变百合和中草药及蜂蜜的组成及比例会显著降低产品的功效，结果差异显著（p<0.01），说明百合、梨花和中草药及蜂蜜之间的协同作用起到了显著提升梨花百合蜜膏功能活性的作用。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例1：
一种梨花百合蜜膏的制备方法，其特征在于包括以下步骤：
（1）分拣称量：将所用中草药分拣，去除杂质，按照百合50份、梨花25份、黄芪13份、厚朴12份、麦冬12份、茯苓16份、熟地12份、当归10份、紫苑14份、枸杞15份、石斛15份、五味子7份、远志7份、甘草12份、甜叶菊13份、蜂蜜1000份比例称重；
（2）原料预处理：根据原料特性不同分别进行原料预处理：
①将百合、梨花、黄芪、厚朴、麦冬、茯苓、当归、熟地、紫苑、石斛、五味子、远志、甘草、甜叶菊混合后进行粉碎处理，过40目筛；
②向枸杞中加入2.5倍纯净水，打浆，然后加入1.5%果胶酶，在40～50℃条件下酶解15min；
（3）超声波辅助酶解：原料混合后加入原料质量比4倍纯净水，然后加入原料质量比2.5%纤维素酶、1.5%非淀粉多糖酶，在超声波辅助条件下酶解45min，酶解温度控制在40～50℃；
（4）离心：离心分离浸提液和中药草残渣；
（5）蒸馏：向中草药残渣中加入4倍量的纯净水，收集挥发油9h，挥发油单独收集放置，水溶液过滤，与浸提液合并；
（6）挥发油乳化：将收集的挥发油中加入1.8%的助溶剂吐温-80，加热乳化；
（7）水煎：将蒸馏后的中草药残渣中加入2.5倍量的水，煎煮3次，每次1.8h，水煎液与浸提液合并；
（8）减压浓缩：将合并后的水溶液浓缩至1g/ml的清膏，放冷；
（9）醇沉：向清膏中加入95%的乙醇使含醇量达到60～70%，4℃条件下放置48h以上
（10）醇提：向水煎后的中草药残渣中加入5倍量的50%乙醇，加热提取2次，提取时间1.8h；
（11）合并抽滤：将醇沉后的液体与醇提液合并抽滤；
（12）减压回收：将抽滤液进行减压回收乙醇至无醇味；
（13）混合：趁热向浓缩液中加入蜂蜜，搅拌均匀；
（14）均质：将混合后的物料进行均质处理；
（15）定容分装：将均质后的蜜膏定容、分装即得成品。
实施例2：
一种梨花百合蜜膏的制备方法，其特征在于包括以下步骤：
（1）分拣称量：将所用中草药分拣，去除杂质，按照百合60份、梨花20份、黄芪15份、厚朴8份、麦冬15份、茯苓15份、熟地13份、当归8份、紫苑15份、枸杞10份、石斛18份、五味子5份、远志10份、甘草10份、甜叶菊15份、蜂蜜1000份比例称重；
（2）原料预处理：根据原料特性不同分别进行原料预处理：
①将百合、梨花、黄芪、厚朴、麦冬、茯苓、当归、熟地、紫苑、石斛、五味子、远志、甘草、甜叶菊混合后进行粉碎处理，过40目筛；
②向枸杞中加入3倍纯净水，打浆，然后加入2%果胶酶，在40～50℃条件下酶解10min；
（3）超声波辅助酶解：原料混合后加入原料质量比5倍纯净水，然后加入原料质量比3%纤维素酶、2%非淀粉多糖酶，在超声波辅助条件下酶解30min，酶解温度控制在40～50℃；
（4）离心：离心分离浸提液和中药草残渣；
（5）蒸馏：向中草药残渣中加入5倍量的纯净水，收集挥发油8h，挥发油单独收集放置，水溶液过滤，与浸提液合并；
（6）挥发油乳化：将收集的挥发油中加入2.0%的助溶剂吐温-80，加热乳化；
（7）水煎：将蒸馏后的中草药残渣中加入3倍量的水，煎煮3次，每次1.5h，水煎液与浸提液合并；
（8）减压浓缩：将合并后的水溶液浓缩至1g/ml的清膏，放冷；
（9）醇沉：向清膏中加入95%的乙醇使含醇量达到60～70%，4℃条件下放置48h以上
（10）醇提：向水煎后的中草药残渣中加入6倍量的50%乙醇，加热提取2次，提取时间1h；
（11）合并抽滤：将醇沉后的液体与醇提液合并抽滤；
（12）减压回收：将抽滤液进行减压回收乙醇至无醇味；
（13）混合：趁热向浓缩液中加入蜂蜜，搅拌均匀；
（14）均质：将混合后的物料进行均质处理；
（15）定容分装：将均质后的蜜膏定容、分装即得成品。
实施例3：
一种梨花百合蜜膏的制备方法，其特征在于包括以下步骤：
（1）分拣称量：将所用中草药分拣，去除杂质，按照百合40份、梨花30份、黄芪10份、厚朴12份、麦冬10份、茯苓20份、熟地10份、当归12份、紫苑10份、枸杞16份、石斛10份、五味子10份、远志5份、甘草15份、甜叶菊10份、蜂蜜1000份比例称重；
（2）原料预处理：根据原料特性不同分别进行原料预处理：
①将百合、梨花、黄芪、厚朴、麦冬、茯苓、当归、熟地、紫苑、石斛、五味子、远志、甘草、甜叶菊混合后进行粉碎处理，过40目筛；
②向枸杞中加入2倍纯净水，打浆，然后加入1%果胶酶，在40～50℃条件下酶解20min；
（3）超声波辅助酶解：原料混合后加入原料质量比3倍纯净水，然后加入原料质量比2%纤维素酶、1%非淀粉多糖酶，在超声波辅助条件下酶解60min，酶解温度控制在40～50℃；
（4）离心：离心分离浸提液和中药草残渣；
（5）蒸馏：向中草药残渣中加入3倍量的纯净水，收集挥发油10h，挥发油单独收集放置，水溶液过滤，与浸提液合并；
（6）挥发油乳化：将收集的挥发油中加入1.5%的助溶剂吐温-80，加热乳化；
（7）水煎：将蒸馏后的中草药残渣中加入2倍量的水，煎煮3次，每次2h，水煎液与浸提液合并；
（8）减压浓缩：将合并后的水溶液浓缩至1g/ml的清膏，放冷；
（9）醇沉：向清膏中加入95%的乙醇使含醇量达到60～70%，4℃条件下放置48h以上
（10）醇提：向水煎后的中草药残渣中加入4倍量的50%乙醇，加热提取2次，提取时间1.5h；
（11）合并抽滤：将醇沉后的液体与醇提液合并抽滤；
（12）减压回收：将抽滤液进行减压回收乙醇至无醇味；
（13）混合：趁热向浓缩液中加入蜂蜜，搅拌均匀；
（14）均质：将混合后的物料进行均质处理；
（15）定容分装：将均质后的蜜膏定容、分装即得成品。
以上实施例仅用于说明本发明的技术方案，而非对其进行限制；尽管参照前述实施例对被发明进行了详细的说明，但对于本领域的普通技术人员来说，依然可以对前述实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而对这些修改或者替换，并不使相应技术方案的本质脱离本发明所要求保护的技术方案的精神和范围。
Claims (1)
1.一种梨花百合蜜膏的制备方法，其特征在于包括以下步骤：
（1）分拣称量：将所用中草药分拣，去除杂质，按照百合40～60份、梨花20～30份、黄芪10～15份、厚朴8～12份、麦冬10～15份、茯苓15～20份、熟地10～13份、当归8～12份、紫苑10～15份、枸杞10～16份、石斛10～18份、五味子5～10份、远志5～10份、甘草10～15份、甜叶菊10～15份、蜂蜜1000份比例称重；
（2）原料预处理：根据原料特性不同分别进行原料预处理：
①将百合、梨花、黄芪、厚朴、麦冬、茯苓、当归、熟地、紫苑、石斛、五味子、远志、甘草、甜叶菊混合后进行粉碎处理，过40目筛；
②向枸杞中加入2～3倍纯净水，打浆，然后加入1～2%果胶酶，在40～50℃条件下酶解10～20min；
（3）超声波辅助酶解：原料混合后加入原料质量比3～5倍纯净水，然后加入原料质量比2～3%纤维素酶、1～2%非淀粉多糖酶，在超声波辅助条件下酶解30～60min，酶解温度控制在40～50℃；
（4）离心：离心分离浸提液和中药草残渣；
（5）蒸馏：向中草药残渣中加入3～5倍量的纯净水，收集挥发油8～10h，挥发油单独收集放置，水溶液过滤，与浸提液合并；
（6）挥发油乳化：将收集的挥发油中加入1.5～2.0%的助溶剂吐温-80，加热乳化；
（7）水煎：将蒸馏后的中草药残渣中加入2～3倍量的水，煎煮3次，每次1.5～2h，水煎液与浸提液合并；
（8）减压浓缩：将合并后的水溶液浓缩至1g/ml的清膏，放冷；
（9）醇沉：向清膏中加入95%的乙醇使含醇量达到60～70%，4℃条件下放置48h以上
（10）醇提：向水煎后的中草药残渣中加入4～6倍量的50%乙醇，加热提取2次，提取时间1～1.5h；
（11）合并抽滤：将醇沉后的液体与醇提液合并抽滤；
（12）减压回收：将抽滤液进行减压回收乙醇至无醇味；
（13）混合：趁热向浓缩液中加入蜂蜜，搅拌均匀；
（14）均质：将混合后的物料进行均质处理；
（15）定容分装：将均质后的蜜膏定容、分装即得成品。
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| CN107637817A (zh) * | 2017-10-30 | 2018-01-30 | 雅安蒋氏蜜蜂园有限公司 | 一种保健蜂蜜粉及其制备方法 |
| CN113303392A (zh) * | 2021-05-19 | 2021-08-27 | 山东省现代中药研究院有限公司 | 一种健脑益智棒棒糖及制备方法 |
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| CN104921132A (zh) * | 2015-07-08 | 2015-09-23 | 青岛嘉瑞生物技术有限公司 | 一种具有润肺止咳消喘功效的中草药保健口服液 |
| CN105435039A (zh) * | 2016-01-02 | 2016-03-30 | 红河州吉昌生物科技有限公司 | 改进型止咳平喘胶囊 |
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| CN104921132A (zh) * | 2015-07-08 | 2015-09-23 | 青岛嘉瑞生物技术有限公司 | 一种具有润肺止咳消喘功效的中草药保健口服液 |
| CN105435039A (zh) * | 2016-01-02 | 2016-03-30 | 红河州吉昌生物科技有限公司 | 改进型止咳平喘胶囊 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107637817A (zh) * | 2017-10-30 | 2018-01-30 | 雅安蒋氏蜜蜂园有限公司 | 一种保健蜂蜜粉及其制备方法 |
| CN113303392A (zh) * | 2021-05-19 | 2021-08-27 | 山东省现代中药研究院有限公司 | 一种健脑益智棒棒糖及制备方法 |
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