CN105943836A - 一种防治雾霾引起的呼吸道疾病的百合蜜膏 - Google Patents
一种防治雾霾引起的呼吸道疾病的百合蜜膏 Download PDFInfo
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Abstract
本发明公开了一种防治雾霾引起的呼吸道疾病的百合蜜膏及其制备方法,该产品中草药原料组成为百合40~60份、梨花20~30份、黄芪10~15份、厚朴8~12份、麦冬10~15份、金银花15~20份、白芍10~13份、当归8~12份、紫苑10~15份、罗汉果10~16份、桔梗10~18份、五味子5~10份、知母5~10份、甘草10~15份、甜叶菊10~15份、蜂蜜1000份,采用“超声波辅助浸提+蒸馏挥发油+水煎+醇提”工艺制备。该产品具有防治雾霾呼吸道疾病功效好、安全无副作用、饮用方便等优势。
Description
技术领域
本发明涉及一种防治雾霾引起的呼吸道疾病的百合蜜膏,特别是一种以梨花、百合及其他植物中草药为原料制成的百合蜜膏,属保健领域。
背景技术
随着社会科技的不断进步,生产生活逐渐趋向工业化,
这一过程在带来经济效益增长的同时,也加剧了对自然环境的破坏。“雾霾”就是近年来人们较为关注的一个环境变化,我国北方地区连续多年出现极端雾霾天气,且出现持续周期长、PM2.5浓度不断增加等趋势。雾霾不仅对人们的日常生活及出行带来不便,也对人类的健康造成了极大的威胁。据报道,中国每年因城市大气污染而造成的呼吸系统门诊病例在35万人以上,而且呈逐年增加之势。雾霾天气,空气中的可吸入性颗粒物增多,尤以有机污染物为主,成分复杂,直径小,可随呼吸而进入支气管、细支气管最后沉降于肺泡,引起支气管炎、肺炎,促发哮喘,
加重老慢支和肺气肿等急慢性呼吸道疾病。另外,长期生活在雾霾环境中,会提高肺癌的发病率。钟南山院士指出,雾霾天气比香烟更易致癌。近30年来,中国公众场所吸烟率不断下降,肺癌患病率却上升了4 倍多。这必须引起人们的警惕及重视。此外,雾霾还容易增加心脑血管疾病发病的风险,如引起冠心病、促发中风;可吸入悬浮颗粒刺激眼、鼻、咽喉及皮肤,可引发结膜炎、过敏性鼻炎、咽炎及过敏性皮炎等。
由雾霾的污染而引起的呼吸道疾病被称为雾霾性呼吸道疾病,典型症状就是咳嗽,并伴随喉咙干痒、咽痛、呼吸困难、气喘等症状。目前在预防和治疗雾霾引起的相关疾病的药物研发才刚刚起步,主要为宣肺止咳、消热清毒、滋阴润燥的一些中药,仍难以满足市场需求,因此开发食疗同源的具有防治雾霾呼吸道疾病的保健产品具有重要意义。
发明内容
为克服现有产品技术的不足,本发明的目的在于提供一种防治雾霾引起的呼吸道疾病的百合蜜膏。
本发明上述目的是通过以下技术方案予以实现的:
本发明提供一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于中草药原料及质量配比为:百合40~60份、梨花20~30份、黄芪10~15份、厚朴8~12份、麦冬10~15份、金银花15~20份、白芍10~13份、当归8~12份、紫苑10~15份、罗汉果10~16份、桔梗10~18份、五味子5~10份、知母5~10份、甘草10~15份、甜叶菊10~15份、蜂蜜1000份。
本发明的优选技术方案是:一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于:其中药原料及质量配比为:百合50份、梨花25份、黄芪13份、厚朴12份、麦冬12份、金银花16份、白芍12份、当归10份、紫苑14份、罗汉果15份、桔梗15份、五味子7份、知母7份、甘草12份、甜叶菊13份、蜂蜜1000份。
本发明提供一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于制备工艺包括以下步骤:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照上述比例称重;
(2)原料预处理:根据原料特性不同分别进行原料预处理:
①将百合、梨花、黄芪、厚朴、麦冬、金银花、当归、白芍、紫苑、桔梗、五味子、知母、甘草、甜叶菊混合后进行粉碎处理,过40目筛;
②向罗汉果中加入2~3倍纯净水,打浆,然后加入1~2%果胶酶,在40~50℃条件下酶解10~20min;
(3)超声波辅助酶解:原料混合后加入原料质量比3~5倍纯净水,然后加入原料质量比2~3%纤维素酶、1~2%非淀粉多糖酶,在超声波辅助条件下酶解30~60min,酶解温度控制在40~50℃;
(4)离心:离心分离浸提液和中药草残渣;
(5)蒸馏:向中草药残渣中加入3~5倍量的纯净水,收集挥发油8~10h,挥发油单独收集放置,水溶液过滤,与浸提液合并;
(6)挥发油乳化:将收集的挥发油中加入1.5~2.0%的助溶剂吐温-80,加热乳化;
(7)水煎:将蒸馏后的中草药残渣中加入2~3倍量的水,煎煮3次,每次1.5~2h,水煎液与浸提液合并;
(8)减压浓缩:将合并后的水溶液浓缩至1g/ml的清膏,放冷;
(9)醇沉:向清膏中加入95%的乙醇使含醇量达到60~70%,4℃条件下放置48h以上
(10)醇提:向水煎后的中草药残渣中加入4~6倍量的50%乙醇,加热提取2次,提取时间1~1.5h;
(11)合并抽滤:将醇沉后的液体与醇提液合并抽滤;
(12)减压回收:将抽滤液进行减压回收乙醇至无醇味;
(13)混合:趁热向浓缩液中加入蜂蜜,搅拌均匀;
(14)均质:将混合后的物料进行均质处理;
(15)定容分装:将均质后的蜜膏定容、分装即得成品。
本发明提供一种防治雾霾引起的呼吸道疾病的百合蜜膏,其优势在于:一是在传统中医理论和实践指导下精选药方,科学配伍百合、梨花和多种中草药,药物组分经辨证配伍,应用我国传统医学“温经通络、活血化瘀”的医疗精髓,从调节引发咳嗽的肺、心、肝、脾等各类脏器的功能入手,调整体内气血平衡,促进体内五脏六腑的新陈代谢和正常功能,使其“气充百脉、活血去淤、养心补肺、调节肾脾、益气生津、润肺清咳”;二是在百合蜜膏的制备过程中采用“超声波辅助浸提+蒸馏挥发油+水煎+醇提”的工艺,充分糅合中草药中的的功能活性成分,提高保健效果;三是百合蜜膏安全无副作用,饮用方便。
本发明提供一种防治雾霾引起的呼吸道疾病的百合蜜膏,通过动物试验进行百合蜜膏的毒理学试验及安全性评价。小鼠急性经口毒性试验结果表明,本百合蜜膏对小鼠急性经口最大耐受剂量大于高剂量组75mg/kg·bw; 遗传毒性试验小鼠骨髓细胞微核试验和小鼠精子畸形试验两项试验结果均为阴性,表明该百合蜜膏无致突变作用;由大鼠30d喂养试验可知,大鼠体征行为正常、体态健康、血液及血液生化指标也无异常变化,因此75mg/kg·bw的剂量(人体推荐量的150倍)属于安全剂量;遗传毒性试验和大鼠30d喂养试验结果均为阴性,因此确定本保健饮料属无毒类食品,人可以安全放心食用。
本发明提供一种防治雾霾引起的呼吸道疾病的百合蜜膏,不同的中草药性味各异,功效存在着巨大的差异,不同的中草药组合后存在复杂的相互作用关系,且中草药之间的配比比较密切,不同配比也将使君臣佐使关系发生实质性的变化,从而使复合中草药的关系发生实质性改变。本申请通过百合、梨花、黄芪、厚朴、麦冬、金银花、白芍、当归、紫苑、罗汉果、桔梗、五味子、知母、甘草、甜叶菊等中草药彼此间存在复杂的相互作用关系,合理配比,取得了预料不到的技术效果,使百合蜜膏的关系发生实质性改变。根据《保健食品功能学评价程序和检验方法》对本申请产品进行了功能性评价,利用小鼠试验测定百合蜜膏对雾霾呼吸道疾病的影响,结果表明饲喂本发明产品在雾霾环境条件下小鼠咳嗽潜伏期延长40.23%、咳嗽次数减少72.55%,与对照组相比差异显著(P<0.01);此外,试验结果表明,改变百合和中草药及蜂蜜的组成及比例会显著降低产品的功效,结果差异显著(p<0.01),说明百合、梨花和中草药及蜂蜜之间的协同作用起到了显著提升百合蜜膏功能活性的作用。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例1:
一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于制备工艺包括以下步骤:
(1)分拣称量:将所用中草药分拣,去除杂质,按照百合50份、梨花25份、黄芪13份、厚朴12份、麦冬12份、金银花16份、白芍12份、当归10份、紫苑14份、罗汉果15份、桔梗15份、五味子7份、知母7份、甘草12份、甜叶菊13份、蜂蜜1000份比例称重;
(2)原料预处理:根据原料特性不同分别进行原料预处理:
①将百合、梨花、黄芪、厚朴、麦冬、金银花、当归、白芍、紫苑、桔梗、五味子、知母、甘草、甜叶菊混合后进行粉碎处理,过40目筛;
②向罗汉果中加入2.5倍纯净水,打浆,然后加入1.5%果胶酶,在40~50℃条件下酶解15min;
(3)超声波辅助酶解:原料混合后加入原料质量比4倍纯净水,然后加入原料质量比2.5%纤维素酶、1.5%非淀粉多糖酶,在超声波辅助条件下酶解45min,酶解温度控制在40~50℃;
(4)离心:离心分离浸提液和中药草残渣;
(5)蒸馏:向中草药残渣中加入4倍量的纯净水,收集挥发油9h,挥发油单独收集放置,水溶液过滤,与浸提液合并;
(6)挥发油乳化:将收集的挥发油中加入1.8%的助溶剂吐温-80,加热乳化;
(7)水煎:将蒸馏后的中草药残渣中加入2.5倍量的水,煎煮3次,每次1.8h,水煎液与浸提液合并;
(8)减压浓缩:将合并后的水溶液浓缩至1g/ml的清膏,放冷;
(9)醇沉:向清膏中加入95%的乙醇使含醇量达到60~70%,4℃条件下放置48h以上
(10)醇提:向水煎后的中草药残渣中加入5倍量的50%乙醇,加热提取2次,提取时间1.8h;
(11)合并抽滤:将醇沉后的液体与醇提液合并抽滤;
(12)减压回收:将抽滤液进行减压回收乙醇至无醇味;
(13)混合:趁热向浓缩液中加入蜂蜜,搅拌均匀;
(14)均质:将混合后的物料进行均质处理;
(15)定容分装:将均质后的蜜膏定容、分装即得成品。
实施例2:
一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于制备工艺包括以下步骤:
(1)分拣称量:将所用中草药分拣,去除杂质,按照百合60份、梨花20份、黄芪15份、厚朴8份、麦冬15份、金银花15份、白芍13份、当归8份、紫苑15份、罗汉果10份、桔梗18份、五味子5份、知母10份、甘草10份、甜叶菊15份、蜂蜜1000份比例称重;
(2)原料预处理:根据原料特性不同分别进行原料预处理:
①将百合、梨花、黄芪、厚朴、麦冬、金银花、当归、白芍、紫苑、桔梗、五味子、知母、甘草、甜叶菊混合后进行粉碎处理,过40目筛;
②向罗汉果中加入3倍纯净水,打浆,然后加入2%果胶酶,在40~50℃条件下酶解10min;
(3)超声波辅助酶解:原料混合后加入原料质量比5倍纯净水,然后加入原料质量比3%纤维素酶、2%非淀粉多糖酶,在超声波辅助条件下酶解30min,酶解温度控制在40~50℃;
(4)离心:离心分离浸提液和中药草残渣;
(5)蒸馏:向中草药残渣中加入5倍量的纯净水,收集挥发油8h,挥发油单独收集放置,水溶液过滤,与浸提液合并;
(6)挥发油乳化:将收集的挥发油中加入2.0%的助溶剂吐温-80,加热乳化;
(7)水煎:将蒸馏后的中草药残渣中加入3倍量的水,煎煮3次,每次1.5h,水煎液与浸提液合并;
(8)减压浓缩:将合并后的水溶液浓缩至1g/ml的清膏,放冷;
(9)醇沉:向清膏中加入95%的乙醇使含醇量达到60~70%,4℃条件下放置48h以上
(10)醇提:向水煎后的中草药残渣中加入6倍量的50%乙醇,加热提取2次,提取时间1h;
(11)合并抽滤:将醇沉后的液体与醇提液合并抽滤;
(12)减压回收:将抽滤液进行减压回收乙醇至无醇味;
(13)混合:趁热向浓缩液中加入蜂蜜,搅拌均匀;
(14)均质:将混合后的物料进行均质处理;
(15)定容分装:将均质后的蜜膏定容、分装即得成品。
实施例3:
一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于制备工艺包括以下步骤:
(1)分拣称量:将所用中草药分拣,去除杂质,按照百合40份、梨花30份、黄芪10份、厚朴12份、麦冬10份、金银花20份、白芍10份、当归12份、紫苑10份、罗汉果16份、桔梗10份、五味子10份、知母5份、甘草15份、甜叶菊10份、蜂蜜1000份比例称重;
(2)原料预处理:根据原料特性不同分别进行原料预处理:
①将百合、梨花、黄芪、厚朴、麦冬、金银花、当归、白芍、紫苑、桔梗、五味子、知母、甘草、甜叶菊混合后进行粉碎处理,过40目筛;
②向罗汉果中加入2倍纯净水,打浆,然后加入1%果胶酶,在40~50℃条件下酶解20min;
(3)超声波辅助酶解:原料混合后加入原料质量比3倍纯净水,然后加入原料质量比2%纤维素酶、1%非淀粉多糖酶,在超声波辅助条件下酶解60min,酶解温度控制在40~50℃;
(4)离心:离心分离浸提液和中药草残渣;
(5)蒸馏:向中草药残渣中加入3倍量的纯净水,收集挥发油10h,挥发油单独收集放置,水溶液过滤,与浸提液合并;
(6)挥发油乳化:将收集的挥发油中加入1.5%的助溶剂吐温-80,加热乳化;
(7)水煎:将蒸馏后的中草药残渣中加入2倍量的水,煎煮3次,每次2h,水煎液与浸提液合并;
(8)减压浓缩:将合并后的水溶液浓缩至1g/ml的清膏,放冷;
(9)醇沉:向清膏中加入95%的乙醇使含醇量达到60~70%,4℃条件下放置48h以上
(10)醇提:向水煎后的中草药残渣中加入4倍量的50%乙醇,加热提取2次,提取时间1.5h;
(11)合并抽滤:将醇沉后的液体与醇提液合并抽滤;
(12)减压回收:将抽滤液进行减压回收乙醇至无醇味;
(13)混合:趁热向浓缩液中加入蜂蜜,搅拌均匀;
(14)均质:将混合后的物料进行均质处理;
(15)定容分装:将均质后的蜜膏定容、分装即得成品。
以上实施例仅用于说明本发明的技术方案,而非对其进行限制;尽管参照前述实施例对被发明进行了详细的说明,但对于本领域的普通技术人员来说,依然可以对前述实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而对这些修改或者替换,并不使相应技术方案的本质脱离本发明所要求保护的技术方案的精神和范围。
Claims (1)
1.一种防治雾霾引起的呼吸道疾病的百合蜜膏,其特征在于制备工艺包括以下步骤:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照百合40~60份、梨花20~30份、黄芪10~15份、厚朴8~12份、麦冬10~15份、金银花15~20份、白芍10~13份、当归8~12份、紫苑10~15份、罗汉果10~16份、桔梗10~18份、五味子5~10份、知母5~10份、甘草10~15份、甜叶菊10~15份、蜂蜜1000份比例称重;
(2)原料预处理:根据原料特性不同分别进行原料预处理:
①将百合、梨花、黄芪、厚朴、麦冬、金银花、当归、白芍、紫苑、桔梗、五味子、知母、甘草、甜叶菊混合后进行粉碎处理,过40目筛;
②向罗汉果中加入2~3倍纯净水,打浆,然后加入1~2%果胶酶,在40~50℃条件下酶解10~20min;
(3)超声波辅助酶解:原料混合后加入原料质量比3~5倍纯净水,然后加入原料质量比2~3%纤维素酶、1~2%非淀粉多糖酶,在超声波辅助条件下酶解30~60min,酶解温度控制在40~50℃;
(4)离心:离心分离浸提液和中药草残渣;
(5)蒸馏:向中草药残渣中加入3~5倍量的纯净水,收集挥发油8~10h,挥发油单独收集放置,水溶液过滤,与浸提液合并;
(6)挥发油乳化:将收集的挥发油中加入1.5~2.0%的助溶剂吐温-80,加热乳化;
(7)水煎:将蒸馏后的中草药残渣中加入2~3倍量的水,煎煮3次,每次1.5~2h,水煎液与浸提液合并;
(8)减压浓缩:将合并后的水溶液浓缩至1g/ml的清膏,放冷;
(9)醇沉:向清膏中加入95%的乙醇使含醇量达到60~70%,4℃条件下放置48h以上
(10)醇提:向水煎后的中草药残渣中加入4~6倍量的50%乙醇,加热提取2次,提取时间1~1.5h;
(11)合并抽滤:将醇沉后的液体与醇提液合并抽滤;
(12)减压回收:将抽滤液进行减压回收乙醇至无醇味;
(13)混合:趁热向浓缩液中加入蜂蜜,搅拌均匀;
(14)均质:将混合后的物料进行均质处理;
(15)定容分装:将均质后的蜜膏定容、分装即得成品。
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