CN105997593A - Prebiotic function formula for adjusting unbalance of skin bacterial flora and relieving eczema - Google Patents
Prebiotic function formula for adjusting unbalance of skin bacterial flora and relieving eczema Download PDFInfo
- Publication number
- CN105997593A CN105997593A CN201610515967.2A CN201610515967A CN105997593A CN 105997593 A CN105997593 A CN 105997593A CN 201610515967 A CN201610515967 A CN 201610515967A CN 105997593 A CN105997593 A CN 105997593A
- Authority
- CN
- China
- Prior art keywords
- skin
- formula
- function formula
- inulin
- aeig
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a sieved prebiotic formula for adjusting unbalance of skin bacterial flora and relieving eczema. The prebioticformula comprises the following active components of artemisia arygi ev.qiai essential oil, inulin and alpha-glucan oligosaccharide according to different ratios, namely AeIG prebiotics. The prebiotic formula has the advantages that the AeIG is used for obviously preventing and adjusting the unbalance of bacterial flora in dermatitis and eczemadisease skin, inhibiting the propagation of potential pathogenic bacteria, such as staphylococcus aureus, and promoting the growth of probiotics, such as bifidobacterium; the AeIG probiotic is used as the basic functional formula, and can be widely applied to preventive cosmetics and therapeutic skin external preparations, such as infant washing and skin-care articles, so as to meet the actual function requirements of children skin-care products.
Description
Technical field
The present invention relates to a kind of prebiotics function formula purposes in cosmetics and external used medicine, particularly relate to dermatitis
The prevention of eczema and treatment, belong to biomedicine field.
Background technology
Human body skin is a big heterogeneous organ, and body can be protected under normal physiological condition from pathogenic microorganism
Invasion, can also maintain affect that people is healthy and balance [the Elizabeth AG of the microorganism species of disease simultaneouslyet al,
Science, 2009,324(5931): 1190-1192].Prebiotics (Prebiotics) can be by optionally stimulating one
Or the growth of minority kind probiotic bacteria and activity and host produced wholesome effect thus improve host health.Research shows benefit
Raw unit can help to safeguard the natural protective barrier of skin surface, increases the skin resistivity to noxious bacteria, keeps skin
Natural balanced state, reduce skin problem generation [Passeron T et al, Dermatology, 2006,61:431-
437】。
Dermatitis eczema is a kind of common epidermis caused by multiple internal and external factor and the inflammatory skin of high dermis
Disease, is easiest to suffer from 2-5 year child especially, and summer and autumn are the most common.Its feature is conscious violent pruritus, skin lesion pleomorphism,
The most symmetrical, have and ooze out tendency, the chronic course of disease, easy recurrent exerbation.Dermatitis eczema can betide any position, is common in face
After portion, buttocks, ear, extremity bend side, breast, hand, scrotum etc..Can be divided into acute, subacute and chronic according to skin lesion feature
Eczema, three there is no obvious boundary, can mutually change.The reason of eczema is the most complicated, with heredity, immunity, environment, physiology and medicine
Reason all has relation, and it takes the form of and is continuous and unbroken, and this plays that and falls, and autologous disseminates, even can be throughout whole body.Though not infecting, but
If not healing prolonged, majority can autologous extend.It is generally believed that skin surface is the same with enteral, originally there is a various bacteria, but by
Cause this balance unbalance in dry environment or body constitution reason, the dermatopathies such as dermatitis eczema will be caused.At present can only
Treat with steroid medicine, if it is possible to thoroughly find out pathogenesis, recover the multiformity of skin bacterium, maybe can find elimination inflammation
The new method of disease.In recent years to probiotic bacteria (Probitics), prebiotics (Prebiotics) and symphysis agent (Synbiotics)
Basic research is that the process of dermatitis eczema provides new means and prophylactico-therapeutic measures [Katherine et al, Journal
of the American Academy of Dermatology,2014, 71(4):814-821】。
Along with biotechnology is being changed at molecular biology, the fast development of medicine and other fields, biotechnology and biological preparation
Multiple links in the cosmetics industry fields such as the research and development of cosmetic raw material, the safety of cosmetics and Efficiency assessment have also been obtained
Being widely popularized and apply, biotechnology is increasingly becoming one of Main way of cosmetic industry future development.Cosmetics industry will
By merging multi-disciplinary high-new scientific and technical result in modern age, improve the safety of cosmetics, the both effectiveness and feature of environmental protection.Natural externally applied benefit
Raw unit just agrees with modern cosmetics safety, the both effectiveness and feature of the feature of environmental protection because of it, has the most become functional cosmetics and has ground
The hot fields studied carefully.
Summary of the invention
A kind of prebiotics function formula alleviating dermatitis eczema, belongs to cosmetics or the doctor deriving from natural plant material
Pharmaceutical formulation, is specifically related to regulation of skin flora unbalance thus alleviate the prebiotics function formula of dermatitis eczema, its merit
Can property components group by Artemisia argyi Levl. et Van. var. argyi cv. Qiai (Artemisia arygi ev.qiai) quintessence oil (Essential Oil), inulin (Inulin) and α-
Glucosan oligosaccharide (α-Glucan Oligosaccharide) forms in proportion.
Further, this prebiotics function formula is made up of by Different Weight percentage ratio following component: 15-70% Artemisia argyi Levl. et Van. var. argyi cv. Qiai
Cosmetics that quintessence oil, 5-40% inulin, 20-50% alpha-glucans oligosaccharide, and this formula are made, external used medicine, can be extensive
Being applied in cosmetics and external medicine preparation, lotion, Emulsion and cream and spray etc., such as infant washing and skin protection are used
Product, can meet the actual efficacy requirement of child's skin care item.
Above-mentioned prebiotics formula (AeIG) can suppress the breeding of the potentially pathogenic organisms such as staphylococcus aureus, and promotes bifid
The growth of the probiotic bacterias such as bacillus, hence it is evident that prevent and to regulate the flora in dermatitis eczema affected skin unbalance, to dermatitis eczema
There is preventive and therapeutic action.
Detailed description of the invention:
Embodiment one: weigh mass percent 33% Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, 33% inulin, 34% alpha-glucans oligosaccharide, miscible in Guangdong
In Tian Le cosmetics company limited many A basic formula of bath cream of dream, make the bath oil of 1000 g, for embodiment test D,
E group.
Embodiment two: weigh mass percent 70% Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, 5% inulin, 25% alpha-glucans oligosaccharide, miscible in
In Guangdong Tian Le cosmetics company limited many A basic formula of bath cream of dream, make the bath oil of 1000 g, try for embodiment
Test F group.
Embodiment three: weigh mass percent 15% Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, 40% inulin, 45% alpha-glucans oligosaccharide, miscible in
In Guangdong Tian Le cosmetics company limited many A basic formula of bath cream of dream, make the bath oil of 1000 g, try for embodiment
Test G group.
Embodiment four: weigh mass percent 50% Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, 30% inulin, 20% alpha-glucans oligosaccharide, miscible in
In Guangdong Tian Le cosmetics company limited many A basic formula of bath cream of dream, make the bath oil of 1000 g, try for embodiment
Test H group.
By 50 Balb/c mices (female, SPF level, 6 week old, body weight body weight 20 scholar 2g, Guangdong Province's Experimental Animal Center
There is provided) it is randomly divided into A, B, C, D, E, F, G, H eight groups, often group 10, A group is Normal group;B group is model group;C is
Positive drug control group；D, E, F, G, H are the AeIG bath oil group of embodiment one to four different proportion formula, and wherein D group is observed
Terminal is one week, and remaining E, F, G, H embodiment is observed 2 weeks, and body weight is more consistent.Experimental procedure is as follows: (1) modeling pharmaceutical intervention
First 1 day mouse web portion shaving, chooses about 4 cm2Expanses of skin is standby;(2) the 1st days, measure 7% DNCB solution with sample injector
25 pL are applied in mouse web portion cropping district sensitization;(3) the 5th days, mouse back shaving, respectively choose about 1 cm about the Mus back of the body2Model
Enclose standby;(4) the 6th days start, and smear the 0.5% DNCB solution 20 pL back of the body in cropping district, the left and right sides, experimental mice back
Portion excites, every 1 time on the 3rd, and totally 4 times.Experiment packet and administration: mice the 4th excites rear 24h, observes respectively and excites position skin
Skin reacts, and according to erythema classification of severity.After modeling success, at C group mouse back skin lesion, it is coated with Tacrolimus paste (0.1%
109 ointment), every day 2 times, continuous 1 week;D group is coated with AeIG bath oil at mouse back skin lesion, every day 2 times, continuous 1 week; E、
AeIG bath oil it is coated with at the skin lesion of F, G, H group back, every day 1 time, continuous 2 weeks;24 h after the 4th excites respectively, observes mice
Excite area skin to react, and l is all and the metamorphosis of histological observation each intervention group back skin lesion after 2 weeks, with reference to improvement
SCORAD method is given a mark.Identifying the kind of microbial bacterial at each mice skin lesion according to 16S rDNA, the method for plate culture count calculates
Its quantity, utilizes SPSS software and carries out statistical analysis.
As shown in table 1, table 2 and table 3, result shows, AeIG group (D group and E group and F group and G group and H group) relative model group
Can be obviously improved dermatitis eczema symptom (P＜ 0.01);And significantly reduce the quantity of staphylococcus aureus in Model B group
(P＜ 0.01), and increase bacillus bifidus quantity (P＜ 0.05)；Two groups of SCORAD scores of AeIG all substantially less than model group (P
＜ 0.01), D group and E group no difference of science of statistics (P＞ 0.05), with positive drug tacrolimus matched group quite (P ＞
0.05)。
Claims (6)
1. the prebiotics function formula of a regulation of skin flora unbalance alleviation eczema, it is characterised in that functional components group is by begging
Chinese mugwort quintessence oil, inulin, alpha-glucans oligosaccharide form in proportion.
Prebiotics function formula the most according to claim 1, it is characterised in that by following component by Different Weight percentage ratio group
Become: 15-70% Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, 5-40% inulin, 20-50% alpha-glucans oligosaccharide.
Prebiotics function formula the most according to claim 1, it is characterised in that by following component by Different Weight percentage ratio group
Become: 33% Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, 33% inulin, 34% alpha-glucans oligosaccharide.
4. according to the application of prebiotics function formula described in claim 1 or 2 or 3, it is characterised in that application product includes making up
Product or external used medicine.
Formula the most according to claim 4 is applied, it is characterised in that described cosmetic product can be that above-mentioned functions basis is joined
Lotion, Emulsion and cream and the spray etc. that side is prepared from.
Formula the most according to claim 4 is applied, it is characterised in that described external used medicine can be that above-mentioned functions basis is joined
Lotion, Emulsion and cream and the spray etc. that side is prepared from.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610515967.2A CN105997593B (en) | 2016-07-04 | 2016-07-04 | A kind of prebiotic meta function formula by adjusting the unbalance dermatitis eczema of alleviation of skin flora |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610515967.2A CN105997593B (en) | 2016-07-04 | 2016-07-04 | A kind of prebiotic meta function formula by adjusting the unbalance dermatitis eczema of alleviation of skin flora |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105997593A true CN105997593A (en) | 2016-10-12 |
| CN105997593B CN105997593B (en) | 2018-11-09 |
Family
ID=57106426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610515967.2A Active CN105997593B (en) | 2016-07-04 | 2016-07-04 | A kind of prebiotic meta function formula by adjusting the unbalance dermatitis eczema of alleviation of skin flora |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105997593B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898939A (en) * | 2017-11-06 | 2018-04-13 | 康柏利科技（苏州）有限公司 | A kind of composition with prevention and treatment infantile eczema |
| CN108403502A (en) * | 2018-04-24 | 2018-08-17 | 上海上水和肌化妆品有限公司 | It improves skin stress reaction and promotes the composition and forming method of probiotics balance |
| CN109431913A (en) * | 2018-12-27 | 2019-03-08 | 湖南御家化妆品制造有限公司 | Skin microecological balance composition and application thereof |
| CN111135125A (en) * | 2020-01-10 | 2020-05-12 | 广州贝玛生物科技有限公司 | Composition capable of improving stretch marks, postpartum repair moisturizer containing composition and preparation method of postpartum repair moisturizer |
| CN111728923A (en) * | 2020-07-07 | 2020-10-02 | 广州柏俐臣化妆品有限公司 | Cleansing water containing prebiotics |
| CN113181074A (en) * | 2021-05-19 | 2021-07-30 | 广东添乐化妆品有限公司 | Composite folic acid anti-allergic and anti-irritation skin care composition and preparation method and application thereof |
| WO2022115074A1 (en) * | 2020-11-30 | 2022-06-02 | Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi | An oil-based product maintaining the balance of skin flora and having moisturizing property |
| GB2589234B (en) * | 2018-05-31 | 2022-08-31 | Kimberly Clark Co | Prebiotic compositions and methods for maintaining a healthy skin microbiota |
| RU2792104C2 (en) * | 2018-05-31 | 2023-03-16 | Кимберли-Кларк Ворлдвайд, Инк. | Prebiotic-based compositions and methods for maintaining healthy skin microbiota |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357137A (en) * | 2007-03-26 | 2009-02-04 | 莱雅公司 | Use of a vitreoscilla filiformis lipopolysaccharide fraction as an agent for stimulating the synthesis of anti-microbial skin peptides |
| CN102459624A (en) * | 2009-05-08 | 2012-05-16 | 格罗宁根大学 | Gluco-oligosaccharides comprising (alpha1 to 4) and (alpha 1to 6) glycosidic bonds, use thereof, and methods for providing them |
| CN104623218A (en) * | 2015-02-13 | 2015-05-20 | 尤娜 | Traditional Chinese medicine facial mask for treating acne and preparation method thereof |
| CN105456180A (en) * | 2015-12-30 | 2016-04-06 | 苏州威尔德工贸有限公司 | Bactericidal rash preventing solution for infant wet tissues and preparation method thereof |
-
2016
- 2016-07-04 CN CN201610515967.2A patent/CN105997593B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357137A (en) * | 2007-03-26 | 2009-02-04 | 莱雅公司 | Use of a vitreoscilla filiformis lipopolysaccharide fraction as an agent for stimulating the synthesis of anti-microbial skin peptides |
| CN102459624A (en) * | 2009-05-08 | 2012-05-16 | 格罗宁根大学 | Gluco-oligosaccharides comprising (alpha1 to 4) and (alpha 1to 6) glycosidic bonds, use thereof, and methods for providing them |
| CN104623218A (en) * | 2015-02-13 | 2015-05-20 | 尤娜 | Traditional Chinese medicine facial mask for treating acne and preparation method thereof |
| CN105456180A (en) * | 2015-12-30 | 2016-04-06 | 苏州威尔德工贸有限公司 | Bactericidal rash preventing solution for infant wet tissues and preparation method thereof |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898939A (en) * | 2017-11-06 | 2018-04-13 | 康柏利科技（苏州）有限公司 | A kind of composition with prevention and treatment infantile eczema |
| CN108403502A (en) * | 2018-04-24 | 2018-08-17 | 上海上水和肌化妆品有限公司 | It improves skin stress reaction and promotes the composition and forming method of probiotics balance |
| GB2589234B (en) * | 2018-05-31 | 2022-08-31 | Kimberly Clark Co | Prebiotic compositions and methods for maintaining a healthy skin microbiota |
| RU2792104C2 (en) * | 2018-05-31 | 2023-03-16 | Кимберли-Кларк Ворлдвайд, Инк. | Prebiotic-based compositions and methods for maintaining healthy skin microbiota |
| CN109431913A (en) * | 2018-12-27 | 2019-03-08 | 湖南御家化妆品制造有限公司 | Skin microecological balance composition and application thereof |
| CN111135125A (en) * | 2020-01-10 | 2020-05-12 | 广州贝玛生物科技有限公司 | Composition capable of improving stretch marks, postpartum repair moisturizer containing composition and preparation method of postpartum repair moisturizer |
| CN111728923A (en) * | 2020-07-07 | 2020-10-02 | 广州柏俐臣化妆品有限公司 | Cleansing water containing prebiotics |
| WO2022115074A1 (en) * | 2020-11-30 | 2022-06-02 | Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi | An oil-based product maintaining the balance of skin flora and having moisturizing property |
| CN113181074A (en) * | 2021-05-19 | 2021-07-30 | 广东添乐化妆品有限公司 | Composite folic acid anti-allergic and anti-irritation skin care composition and preparation method and application thereof |
| CN113181074B (en) * | 2021-05-19 | 2022-11-25 | 广东添乐化妆品有限公司 | Compound folic acid anti-allergic and anti-irritation skin care composition as well as preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105997593B (en) | 2018-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105997593A (en) | Prebiotic function formula for adjusting unbalance of skin bacterial flora and relieving eczema | |
| CN103462881B (en) | A kind of composition and method of making the same promoting skin microecological balance | |
| CN107823222B (en) | Nano composite antibacterial agent and preparation method and application thereof | |
| JP6309967B2 (en) | Associated with S. aureus, Pseudomonas aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloaca, Proteus mirabilis, Bacteroides fragilis, Staphylococcus epidermidis, Acne, Candida albicans, and / or B. Methods for preventing and / or treating infection, colonization, or disease | |
| DE60023919T2 (en) | IMPROVED TOPICAL COMPOSITIONS WITH EXTRACELLULAR PRODUCTS OF PROBIOTIC BACTERIA AND USES THEREOF | |
| WO2008140200A1 (en) | External compositions for the skin | |
| CN106794202A (en) | Improve the composition and method of human health and nutrition | |
| CN110200884B (en) | Composition with oil control and repair effects, preparation method thereof and application thereof in cosmetics | |
| CN105997718A (en) | Infant hip care cream and preparation method thereof | |
| JP2021529768A (en) | Lactobacillus for skin care | |
| CN102176916A (en) | Acne treatment compositions comprising nanosilver and uses | |
| CN112245347A (en) | Hip-protecting composition for preventing and treating diaper rash and preparation method thereof | |
| CN110974830A (en) | External composition for preventing, relieving or treating skin allergy and application thereof | |
| CN107303253A (en) | It is a kind of to be used to be damaged renovation agent of skin and preparation method thereof | |
| CN106266384A (en) | A kind of plant ointment preventing and treating infant diaper rash and preparation method thereof | |
| CN112022895A (en) | Composition for skin barrier repair and preparation method thereof | |
| KR102270709B1 (en) | Cosmetic composition for skin improvement containing complex ceramide and natural extracts | |
| KR20080011847A (en) | Natural antibiotic and method of manufacturing the same | |
| CN103157095A (en) | Kidney bean phytolectin applications in preparation of human drugs and drug composition thereof | |
| CN103249419B (en) | There is antibacterial and wound healing activity compositions | |
| CN107088169A (en) | Baby moistening frost | |
| KR101835799B1 (en) | A cosmetic composition for manufacturing by the using of propolis, and the cosmetic manufactured by the composition | |
| CN112022795A (en) | Skin care and repair composition, preparation method and application thereof | |
| CN116531547A (en) | Cedar plant extract anti-allergy repair essence disposable sanitary product nursing base material, preparation method and application | |
| CN112826790B (en) | Pet shower gel capable of improving skin micro-ecology and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |