CN105997593B - A kind of prebiotic meta function formula by adjusting the unbalance dermatitis eczema of alleviation of skin flora - Google Patents
A kind of prebiotic meta function formula by adjusting the unbalance dermatitis eczema of alleviation of skin flora Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/10—Washing or bathing preparations
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Abstract
The invention discloses a kind of unbalance prebiotics formulas for alleviating eczema of adjusting skin flora filtered out, and formula active component group is by Chinese mugwort（Artemisia arygi ev.qiai）Essential oil（Essential Oil）, inulin（Inulin）With alpha-glucans oligosaccharides（α-Glucan Oligosaccharide）It is formed by different proportion, abbreviation AeIG prebiotics；AeIG can obviously prevent and the flora adjusted in dermatitis eczema affected skin is unbalance, inhibit the breeding of the potentially pathogenic organisms such as staphylococcus aureus, and promote the growth of the probiotics such as Bifidobacterium.AeIG prebiotics can be widely applied to as basic functional formulas in preventative cosmetics and therapeutic skin external preparation, such as infant's washing and skincare product, meet the actual efficacy requirement of children's skin care item.
Description
Technical field
The purposes that the present invention relates to a kind of prebiotic meta function formulas in cosmetics and external used medicine more particularly to dermatitis
The prevention and treatment of eczema, belongs to biomedicine field.
Background technology
Human skin is a big heterogeneous sexual organ, body can be protected from pathogenic microorganism under normal physiological condition
Invasion, while can also maintain to influence the balance of the microorganism species of people's health and disease【Elizabeth AGet al,
Science, 2009, 324（5931）：1190-1192】.Prebiotics（Prebiotics）It can be a kind of by the stimulation of selectivity
Or the growth of a small number of kind of probiotic bacterias is with activity and to host's generation wholesome effect so as to improve host health.Research shows that beneficial
Raw member can help to safeguard the natural protective barrier of skin surface, increases resistivity of the skin to harmful bacteria, keeps skin
Natural balanced state, reduce skin problem generation【Passeron T et al, Dermatology,2006, 61:431-
437】。
Dermatitis eczema is a kind of common epidermis caused by a variety of internal and external factors and the inflammatory skin of high dermis
Disease is easiest to suffer from 2-5 Sui children especially, and summer and autumn are particularly common.Its feature is to feel violent itch, skin lesion pleomorphism,
It is often symmetrical, there is exudation to be inclined to, the chronic course of disease, easy recurrent exerbation.Dermatitis eczema can betide any position, be common in face
After portion, buttocks, ear, four limbs bend side, breast, hand, scrotum etc..It can be divided into according to skin lesion feature acute, subacute and chronic
Eczema, three have no apparent boundary, can mutually convert.The reason of eczema, is very complicated, with hereditary, immune, environment, physiology and medicine
Reason has relationship, takes the form of and is continuous and unbroken, this plays that and falls, and disseminates self, or even can spread whole body.Though it does not infect,
If do not recovered for a long time, majority can extend self.It is generally believed that skin surface, as enteral, original there are many bacteriums, but by
Cause this balance unbalance in dry environment or constitution reason, the dermatopathies such as dermatitis eczema will be caused.At present can only
It is treated with steroid medicine, if it is possible to thoroughly find out pathogenesis, restore the diversity of skin bacterium, or elimination inflammation can be found
The new method of disease.In recent years to probiotics（Probitics）, prebiotics（Prebiotics）And symphysis agent（Synbiotics）'s
Basic research provides new means and control measure for the processing of dermatitis eczema【Katherine et al, Journal
of the American Academy of Dermatology,2014, 71(4):814-821】。
As biotechnology is being changed in molecular biology, the fast development of medicine and other fields, biotechnology and biological agent
Multiple links in the cosmetics industries fields such as the research and development of cosmetic raw material, the safety of cosmetics and Efficiency assessment also obtain
It is widely popularized and applies, biotechnology is increasingly becoming one of the Main way of cosmetic industry future development.Cosmetics industry will
By merging modern age multi-disciplinary high-new scientific and technical result, the safety of cosmetics, the both effectiveness and feature of environmental protection are improved.Natural externally applied benefit
The characteristics of raw member just agrees with modern cosmetics safety, the both effectiveness and feature of environmental protection because of it, has become functional cosmetics and grinds at present
The hot fields studied carefully.
Invention content
A kind of prebiotic meta function formula for alleviating dermatitis eczema, belongs to the cosmetics from natural plant material or doctor
It is unbalance to alleviate the prebiotic meta function formula of dermatitis eczema, work(to be specifically related to adjusting skin flora for pharmaceutical formulation
Energy property components group is by Chinese mugwort（Artemisia arygi ev.qiai）Essential oil（Essential Oil）, inulin（Inulin）With α-
Glucan oligosaccharides（α-Glucan Oligosaccharide）It forms in proportion.
Further, which is made of following component by different weight percentage：15-70% Chinese mugworts
Cosmetics, external used medicine made of essential oil, 5-40% inulin, 20-50% alpha-glucans oligosaccharides and the formula, can be extensive
Applied in cosmetics and external medicine preparation, lotion, emulsion and cream and spray etc., such as infant's washing and skin care are used
Product can meet the actual efficacy requirement of children's skin care item.
Above-mentioned prebiotics formula（AeIG）It can inhibit the breeding of the potentially pathogenic organisms such as staphylococcus aureus, and promote bifid
The growth of the probiotics such as bacillus, hence it is evident that prevent and the flora adjusted in dermatitis eczema affected skin is unbalance, to dermatitis eczema
With preventive and therapeutic action.
Specific implementation mode：
Embodiment one：Weigh 33% Chinese mugwort essential oil of mass percent, 33% inulin, 34% alpha-glucans oligosaccharides, it is miscible in
In the basic formula of bath cream of the more A dreams of Guangdong Tian Le cosmetics Co., Ltd, the bath oil of 1000 g is made, is tried for embodiment
Test D, E group.
Embodiment two：Weigh 70% Chinese mugwort essential oil of mass percent, 5% inulin, 25% alpha-glucans oligosaccharides, it is miscible in
In the basic formula of bath cream of the more A dreams of Guangdong Tian Le cosmetics Co., Ltd, the bath oil of 1000 g is made, is tried for embodiment
Test F groups.
Embodiment three：Weigh 15% Chinese mugwort essential oil of mass percent, 40% inulin, 45% alpha-glucans oligosaccharides, it is miscible in
In the basic formula of bath cream of the more A dreams of Guangdong Tian Le cosmetics Co., Ltd, the bath oil of 1000 g is made, is tried for embodiment
Test G groups.
Example IV：Weigh 50% Chinese mugwort essential oil of mass percent, 30% inulin, 20% alpha-glucans oligosaccharides, it is miscible in
In the basic formula of bath cream of the more A dreams of Guangdong Tian Le cosmetics Co., Ltd, the bath oil of 1000 g is made, is tried for embodiment
Test H groups.
By 80 Balb/c mouse（Female, SPF grades, 6 week old, 20 scholar 2g of weight weight, Guangdong Province's Experimental Animal Center
It provides）It is randomly divided into eight groups of A, B, C, D, E, F, G, H, every group 10, A groups are Normal group;B groups are model group;C is
Positive drug control group；D, E, F, G, H are the AeIG bath oil groups of one to four different proportion formula of embodiment, and wherein D groups are observed
Terminal is one week, remaining E, F, G, H embodiment is observed 2 weeks, and weight is more consistent.Experimental procedure is as follows：(1) modeling pharmaceutical intervention
Preceding 1 day mouse web portion shaving chooses about 4 cm2Expanses of skin is spare;(2) the 1st days, 7% DNCB solution is measured with sample injector
25 pL are applied to mouse web portion cropping area sensitization;(3) the 5th days, mouse back shaving, mouse carried on the back about 1 cm of each selection in left and right2Model
It encloses spare;Start within (4) the 6th days, 0.5% DNCB solution, the 20 pL back ofs the body are smeared in cropping area at left and right sides of experimental mice back
Portion excites, every 1 time on the 3rd, totally 4 times.Experiment packet and administration:After the excitation of mouse the 4th for 24 hours, observation excites position skin respectively
Skin reacts, and according to erythema classification of severity.After modeling success, Tacrolimus paste (0.1% is applied at C group mouse back skin lesions
109 ointment), 2 times a day, continuous 1 week;D groups apply AeIG bath oils at mouse back skin lesion, 2 times a day, continuous 1 week; E,
F, AeIG bath oils, one time a day, continuous 2 weeks are applied at the skin lesion of G, H group back;24 h after the 4th excitation respectively, observe mouse
Excite area skin reaction and after l weeks and 2 weeks each intervention group back skin lesion of histological observation metamorphosis, with reference to improvement
SCORAD methods are given a mark.Identify that the type of microbial bacterial at each mouse skin lesion, the method for plate culture count are calculated according to 16S rDNA
Its quantity using SPSS softwares and carries out statistical analysis.
As shown in table 1, table 2 and table 3, the results showed that, AeIG groups（D groups and E groups and F groups and G groups and H groups）Relative model group
The symptom of dermatitis eczema can be obviously improved（P< 0.01);And significantly reduce the quantity of the staphylococcus aureus in Model B group
（P< 0.01), and increase the quantity of Bifidobacterium（P< 0.05)；Two groups of SCORAD scores of AeIG are substantially less than model group（P
< 0.01), both D groups and E groups no difference of science of statistics（P> 0.05）, suitable with positive drug tacrolimus control group（P >
0.05)。
Table 1 gives AeIG bath oils, and SCORAD gives a mark before and after the processing
| Group | Before giving AeIG bath oils | It gives before AeIG bath oils after 1 week | After giving AeIG bath oils 2 weeks |
| A | 7.6±4.2 | / | / |
| B | 29.7±4.5 | 32.7±4.5 | 38.9±4.3 |
| C | 29.3±3.7 | 25.4±3.5 | 16.3±4.8 |
| D | 29.1±4.1 | 20.4±6.8 | / |
| E | 30.5±5.7 | 18..6±5.7 | 11..6±6.7 |
| F | 28.9±3.7 | 22.1±5.5 | 13.2±5.4 |
| G | 28.7±5.7 | 21.4±6.1 | 15.2±4.9 |
| H | 29.4±4.9 | 19.3±5.8 | 15.4±7.1 |
Table 2 gives AeIG bath oils staphylococcus aureus relative populations before and after the processing
| Group | Before giving AeIG bath oils | It gives before AeIG bath oils after 1 week | After giving AeIG bath oils 2 weeks |
| A | 7.1±4.9 | / | / |
| B | 24.2±3.8 | 26.9±3.5 | 32.1±4.7 |
| C | 21.7±6.7 | 15.4±3.7 | 12.3±4.8 |
| D | 22.8±4.5 | 10.4±6.2 | / |
| E | 19.4±4.9 | 11..6±5.1 | 9.6±3.7 |
| F | 15.6±4.8 | 12.1±5.5 | 9.2±5.4 |
| G | 19.6±5.5 | 13.4±4.1 | 8.2±3.9 |
| H | 18.7±6.2 | 14.4±3.9 | 10.4±3.4 |
Table 3 gives AeIG bath oils Bifidobacterium bacterium relative populations before and after the processing
| Group | Before giving AeIG bath oils | It gives before AeIG bath oils after 1 week | After giving AeIG bath oils 2 weeks |
| A | 4.2±3.0 | / | / |
| B | 1.1±0.5 | 0.6±0.4 | 0.5±0.5 |
| C | 1.4±0.7 | 0.9±0.6 | 0.6±0.7 |
| D | 1.2±0.9 | 2.4±1.8 | / |
| E | 1.5±0.8 | 3.0±2.1 | 3.2±1.9 |
| F | 1.7±0.6 | 3.5±2.2 | 3.4±1.6 |
| G | 1.2±0.5 | 2.8±3.1 | 3.7±2.0 |
| H | 1.9±0.8 | 2.5±1.6 | 3.6±2.2 |
Claims (6)
1. it is a kind of adjust skin flora it is unbalance alleviate eczema prebiotics, it is characterised in that functional components group by Chinese mugwort essential oil,
Inulin, alpha-glucans oligosaccharides form in proportion.
2. prebiotics according to claim 1, which is characterized in that be made of by different weight percentage following component：15-
70% Chinese mugwort essential oil, 5-40% inulin, 20-50% alpha-glucans oligosaccharides.
3. prebiotics according to claim 1, which is characterized in that be made of by different weight percentage following component：33%
Chinese mugwort essential oil, 33% inulin, 34% alpha-glucans oligosaccharides.
4. according to the application of claims 1 or 2 or 3 prebiotics, which is characterized in that application product includes cosmetics or external application
Drug.
5. the application of prebiotics according to claim 4, which is characterized in that the cosmetic product is that above-mentioned functional basis is matched
Lotion, emulsion and the cream and spray being just prepared.
6. the application of prebiotics according to claim 4, which is characterized in that the external used medicine is that above-mentioned functional basis is matched
Lotion, emulsion and the cream and spray being just prepared.
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| CN107898939A (en) * | 2017-11-06 | 2018-04-13 | 康柏利科技（苏州）有限公司 | A kind of composition with prevention and treatment infantile eczema |
| CN108403502A (en) * | 2018-04-24 | 2018-08-17 | 上海上水和肌化妆品有限公司 | It improves skin stress reaction and promotes the composition and forming method of probiotics balance |
| WO2019231776A1 (en) * | 2018-05-31 | 2019-12-05 | Kimberly-Clark Worldwide, Inc. | Prebiotic compositions and methods for maintaining a healthy skin microbiota |
| CN109431913B (en) * | 2018-12-27 | 2021-05-04 | 湖南御家化妆品制造有限公司 | Skin microecological balance composition and application thereof |
| CN111135125A (en) * | 2020-01-10 | 2020-05-12 | 广州贝玛生物科技有限公司 | Composition capable of improving stretch marks, postpartum repair moisturizer containing composition and preparation method of postpartum repair moisturizer |
| CN111728923A (en) * | 2020-07-07 | 2020-10-02 | 广州柏俐臣化妆品有限公司 | Cleansing water containing prebiotics |
| TR202019237A1 (en) * | 2020-11-30 | 2022-06-21 | Eczacibasi Tueketim Ueruenleri Sanayi Ve Ticaret Anonim Sirketi | AN OIL-BASED PRODUCT THAT MAINTAINS THE BALANCE OF THE SKIN FLORA AND HAS MOISTURIZING PROPERTIES |
| CN113181074B (en) * | 2021-05-19 | 2022-11-25 | 广东添乐化妆品有限公司 | Compound folic acid anti-allergic and anti-irritation skin care composition as well as preparation method and application thereof |
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| CN102459624A (en) * | 2009-05-08 | 2012-05-16 | 格罗宁根大学 | Gluco-oligosaccharides comprising (alpha1 to 4) and (alpha 1to 6) glycosidic bonds, use thereof, and methods for providing them |
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