CN105992589A - 新型免疫治疗组合物及其用途 - Google Patents

新型免疫治疗组合物及其用途 Download PDF

Info

Publication number
CN105992589A
CN105992589A CN201480052398.1A CN201480052398A CN105992589A CN 105992589 A CN105992589 A CN 105992589A CN 201480052398 A CN201480052398 A CN 201480052398A CN 105992589 A CN105992589 A CN 105992589A
Authority
CN
China
Prior art keywords
seq
ara
peptides
allergy
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201480052398.1A
Other languages
English (en)
Chinese (zh)
Inventor
罗宾·伊利莎白·奥赫尔
萨拉·拉谢尔·普里克特
珍妮弗·梅·罗兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ala Waxman Ltd
Original Assignee
Ala Waxman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013903686A external-priority patent/AU2013903686A0/en
Application filed by Ala Waxman Ltd filed Critical Ala Waxman Ltd
Priority to CN202511626174.3A priority Critical patent/CN121714673A/zh
Publication of CN105992589A publication Critical patent/CN105992589A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
CN201480052398.1A 2013-09-25 2014-09-25 新型免疫治疗组合物及其用途 Withdrawn CN105992589A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511626174.3A CN121714673A (zh) 2013-09-25 2014-09-25 新型免疫治疗组合物及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2013903686 2013-09-25
AU2013903686A AU2013903686A0 (en) 2013-09-25 Novel immunotherapeutic composition and uses thereof
PCT/AU2014/050249 WO2015042664A1 (en) 2013-09-25 2014-09-25 Novel immunotherapeutic composition and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202511626174.3A Division CN121714673A (zh) 2013-09-25 2014-09-25 新型免疫治疗组合物及其用途

Publications (1)

Publication Number Publication Date
CN105992589A true CN105992589A (zh) 2016-10-05

Family

ID=52741648

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480052398.1A Withdrawn CN105992589A (zh) 2013-09-25 2014-09-25 新型免疫治疗组合物及其用途
CN202511626174.3A Pending CN121714673A (zh) 2013-09-25 2014-09-25 新型免疫治疗组合物及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202511626174.3A Pending CN121714673A (zh) 2013-09-25 2014-09-25 新型免疫治疗组合物及其用途

Country Status (11)

Country Link
US (3) US11266737B2 (https=)
EP (2) EP3049098A4 (https=)
JP (1) JP7007534B2 (https=)
KR (1) KR20160075532A (https=)
CN (2) CN105992589A (https=)
AU (2) AU2014328483B2 (https=)
BR (1) BR112016006813A2 (https=)
MX (1) MX376449B (https=)
RU (1) RU2689552C2 (https=)
WO (1) WO2015042664A1 (https=)
ZA (1) ZA201602043B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2914286T3 (pl) 2012-10-30 2022-01-31 Aravax Pty Ltd Nowe cząsteczki immunoterapeutyczne oraz ich zastosowania
WO2015042664A1 (en) 2013-09-25 2015-04-02 Monash University Novel immunotherapeutic composition and uses thereof
EP3938053A4 (en) * 2019-03-13 2023-03-22 Psomagen, Inc. EPITOP-BASED APPROACH TO ALLERGY TREATMENTS AND INHIBITORS FOR CROHN'S DISEASE
US20240042016A1 (en) * 2020-12-30 2024-02-08 The Regents Of The University Of Michigan Nanoemulsion vaccine compositions and methods for suppressing reactivity to multiple food allergens

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5558869A (en) 1992-12-30 1996-09-24 University Of Arkansas Major peanut allergen ara h II
EP0873135B1 (en) 1995-12-29 2009-07-22 The University of Arkansas Peanut allergens and methods
US6835824B1 (en) * 1995-12-29 2004-12-28 University Of Arkansas Peanut allergens and methods
US20030202980A1 (en) 1995-12-29 2003-10-30 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
GB2348808B (en) 1998-01-09 2003-03-19 Circassia Ltd Methods and compositions for desensitisation
DE69921773D1 (de) 1998-01-16 2004-12-16 Univ Johns Hopkins Orale verabreichung von nukleinsäure-impstoffen durch partikelkomplexe
AU743647B2 (en) 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions
AU3085299A (en) 1998-03-12 1999-09-27 Board Of Trustees Of The University Of Arkansas, The Tertiary structure of peanut allergen ara h 1
AU3717600A (en) 1999-03-02 2000-09-21 Board Of Trustees Of The University Of Arkansas, The Methods and reagents for decreasing clinical reaction to allergy
WO2000051647A2 (en) 1999-03-03 2000-09-08 Mount Sinai School Of Medicine Of New York University Animal model of allergies
WO2000054803A2 (en) 1999-03-16 2000-09-21 Panacea Pharmaceuticals, Llc Immunostimulatory nucleic acids and antigens
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US20030235594A1 (en) 1999-09-14 2003-12-25 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
AU2065801A (en) 1999-12-06 2001-06-12 Panacea Pharmaceuticals, Llc Passive desensitization
US20020147140A1 (en) 2000-01-31 2002-10-10 Rosen Craig A. Nucleic acids, proteins, and antibodies
RU2285042C2 (ru) 2000-11-16 2006-10-10 Альк-Абелло А/С Новые мутантные аллергены
ATE414773T1 (de) 2000-11-16 2008-12-15 Alk Abello As Mutante allergene
AU2002306850A1 (en) 2001-03-16 2002-10-03 Panacea Pharmaceuticals Methods and reagents for decreasing clinical reaction to allergy
GB0110432D0 (en) 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
MXPA03010037A (es) 2001-05-01 2004-06-30 Univ California Moleculas de fusion y metodos para tratamiento de enfermedades inmunes.
EP1453539B1 (en) 2001-12-05 2008-11-19 Circassia Limited Immunotherapeutic methods and systems
US7179645B2 (en) * 2002-09-24 2007-02-20 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
CA2499123A1 (en) * 2002-09-17 2004-04-15 Antigen Express, Inc. Ii-key/antigenic epitope hybrid peptide vaccines
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof
US8057800B2 (en) * 2004-06-10 2011-11-15 Circassia Limited Immunointeractive molecules and uses thereof
US7566456B2 (en) 2005-06-23 2009-07-28 Haiming Chen Allergen vaccine proteins for the treatment and prevention of allergic diseases
FI20075063A0 (fi) * 2007-02-01 2007-02-01 Vactech Oy Allergisen herkistymisen estäminen
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
NZ583362A (en) 2007-08-15 2012-06-29 Circassia Ltd Peptide with reduced dimer formation
GB2455108A (en) 2007-11-28 2009-06-03 Circassia Ltd T-Cell dependent method for detecting non-allergic or intrinsic disorders
EP2140880B1 (en) 2008-07-04 2012-11-14 HAL Allergy Holding B.V. Modification of allergens
EP2331124A1 (en) 2008-08-15 2011-06-15 Circassia Limited T-cell antigen peptide from allergen for stimulation of il-10 production
ES2378870T5 (es) 2008-08-15 2016-02-03 Circassia Limited Vacuna que comprende péptidos Amb a 1 para uso en el tratamiento de alergia a ambrosía
GB0821806D0 (en) 2008-11-28 2009-01-07 Circassia Ltd Compositions with reduced dimer formation
EP2233502A1 (en) 2009-03-27 2010-09-29 Deutsches Rheuma-Forschungszentrum Berlin Sialylated antigen-specific antibodies for treatment or prophylaxis of unwanted inflammatory immune reactions and methods of producing them
EP2478373B1 (en) 2009-09-14 2019-01-09 Icahn School of Medicine at Mount Sinai Methods for characterizing antibody binding affinity and epitope diversity in food allergy
WO2011106645A1 (en) 2010-02-26 2011-09-01 Benaroya Research Institute Direct analysis of antigen-specific immune response
US8835361B2 (en) 2010-06-01 2014-09-16 The Curators Of The University Of Missouri High-throughput quantitation of crop seed proteins
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US20140080730A1 (en) 2011-03-20 2014-03-20 The Regents Of The University Of Colorado, A Body Corporate Method for predicting severity of allergic reaction
MX374963B (es) 2011-04-29 2025-03-06 Selecta Biosciences Inc Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos.
JP2013040138A (ja) 2011-08-17 2013-02-28 Univ Of Tsukuba 活性化型リコンビナント花粉アレルゲンの作製方法
WO2013036301A1 (en) 2011-09-06 2013-03-14 Selecta Biosciences, Inc. Induced tolerogenic dendritic cells for inducing regulatory b cells
CN102533781B (zh) 2011-12-30 2013-09-11 华南师范大学 花生2s-4b蛋白在诱导细胞凋亡中的应用
CN102816232B (zh) 2011-12-30 2014-07-16 华南师范大学 花生2s-4b蛋白及其生产方法
CA2861003C (en) 2012-01-13 2023-03-28 Julius-Maximilians-Universitat Wurzburg Dual antigen-induced bipartite functional complementation
AU2012382406B2 (en) 2012-06-15 2017-12-07 Immunomic Therapeutics, Inc. Nucleic acids for treatment of allergies
PL2914286T3 (pl) 2012-10-30 2022-01-31 Aravax Pty Ltd Nowe cząsteczki immunoterapeutyczne oraz ich zastosowania
DK2914285T3 (en) 2012-11-01 2017-02-27 Veterinærinstituttet New fusion proteins for the treatment of allergic diseases
MY193724A (en) 2013-03-15 2022-10-27 Sementis Ltd Immune modulation
WO2015042664A1 (en) 2013-09-25 2015-04-02 Monash University Novel immunotherapeutic composition and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JONES SM等: "Clinical efficacy and immune regulation with peanut oral immunotherapy", 《J ALLERGY CLIN IMMUNOL》 *
S.R. PRICKETT等: "Ara h1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeutic", 《CLINICAL & EXPERIMENTAL ALLERGY》 *
S.R. PRICKETT等: "Ara h2 peptides containing dominant CD4+ T-cell epitopes:Candidates for a peanut allergy therapeutic", 《J ALLERGY CLIN IMMUNOL》 *

Also Published As

Publication number Publication date
US11266737B2 (en) 2022-03-08
AU2020200883B2 (en) 2022-05-12
AU2020200883A1 (en) 2020-02-27
RU2016115732A (ru) 2017-10-30
US20220280637A1 (en) 2022-09-08
ZA201602043B (en) 2022-08-31
JP7007534B2 (ja) 2022-01-24
WO2015042664A1 (en) 2015-04-02
RU2016115732A3 (https=) 2018-06-19
EP4710935A3 (en) 2026-05-06
US20160375130A1 (en) 2016-12-29
EP3049098A1 (en) 2016-08-03
US11986522B2 (en) 2024-05-21
CN121714673A (zh) 2026-03-24
AU2014328483A1 (en) 2016-04-21
AU2014328483B2 (en) 2019-11-14
CA2925480A1 (en) 2015-04-02
RU2689552C2 (ru) 2019-05-28
EP4710935A2 (en) 2026-03-18
JP2016533341A (ja) 2016-10-27
BR112016006813A2 (pt) 2017-09-19
US20240415955A1 (en) 2024-12-19
EP3049098A4 (en) 2017-08-16
MX376449B (es) 2025-03-07
MX2016003363A (es) 2016-09-23
KR20160075532A (ko) 2016-06-29

Similar Documents

Publication Publication Date Title
KR101699554B1 (ko) 백신용 펩티드
AU2019240574B2 (en) Novel immunotherapeutic molecules and uses thereof
CN102762225B (zh) 用于针对桦树过敏的疫苗的肽
AU2020200883B2 (en) Novel immunotherapeutic composition and uses thereof
EA020792B1 (ru) Пептиды трав для вакцины
JPWO1997032600A1 (ja) アレルギー疾患に対するペプチド免疫療法剤
JP7174492B2 (ja) S-アレスチンペプチドおよびその治療的使用
JP7778696B2 (ja) S-アレスチンペプチドを含む組成物
CA2925480C (en) Novel immunotherapeutic composition and uses thereof
AU2013203568B2 (en) Peptides for desensibilization against allergens
JP2023520989A (ja) 1型糖尿病の予防および治療に有用なtレジトープ構築物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20161005