CN105963348A - Traditional Chinese medicine spica prunellae extract for increasing egg laying rate of hen - Google Patents
Traditional Chinese medicine spica prunellae extract for increasing egg laying rate of hen Download PDFInfo
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- CN105963348A CN105963348A CN201610502401.6A CN201610502401A CN105963348A CN 105963348 A CN105963348 A CN 105963348A CN 201610502401 A CN201610502401 A CN 201610502401A CN 105963348 A CN105963348 A CN 105963348A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a traditional Chinese medicine spica prunellae extract for increasing egg laying rate of hen. The spica prunellae extract is prepared by steps: (a) mixing dry spica prunellae and grangea maderaspatana, grinding, adopting 65%-75% ethanol solution for heat reflux extraction, combining extract liquor, and concentrating until no alcohol taste is reserved, so that ethanol extract concentrated liquor is obtained; (b) diluting the ethanol extract concentrated liquor obtained at the step (a) with water, sequentially adopting petroleum ether, ethyl acetate and water saturated n-butyl alcohol for extraction, and performing vacuum concentration to obtain petroleum ether extract, ethyl acetate extract and n-butyl alcohol extract respectively; (c) dissolving the n-butyl alcohol extract in water, filtering, adopting AB-8 type macroporous resin for enriching active components, using 6-10% ethyl alcohol for flushing 7-9 column volumes to remove high-polarity components, then using 70-80% ethyl alcohol for eluting 13-17 column volumes, collecting 70-80% ethyl alcohol eluant, and performing vacuum concentration, wherein the spica prunellae accounts for 5%-15% of the total weight of the grangea maderaspatana.
Description
Technical field
The invention belongs to animal husbandry, relate to veterinary drug, be specifically related to a kind of Chinese medicine Spica Prunellae extract improving hen laying rate, should
Extract can significantly improve hen laying rate.
Background technology
Spica Prunellae is the fruit ear of labiate Spica Prunellae.Summer makes an uproar down when fruit ear half is withered, dries.Former plant Spica Prunellae is
Perennial herb.Stem is square, and base portion is crawled, high about 30 centimetres, the close raw fine, soft fur of Herb.Leaf is to life；The Ye Youbing of nearly base portion,
Upper leaf stockless；Blade ellipticity lanceolar, Quan Yuan, or slightly sawtooth.Wheel umbrella inflorescence top is raw, in spike；Bract kidney shape,
Base portion cuts shape or slightly in heart-shaped, and dashing forward the tapering shape of growth shape of tail in top, is backed with coarse wool；Calyx lip, there is coarse wool in front, after
Side is smooth, and upper lip oblong, 3 split, and both sides are extended to half lanceolar, and lower lip 2 splits, sliver triangle, and tip is tapering；
Corolla purple or white, lip, lower tubular, upper lip style hat shape, 2 split, and lower lip is open and flat, and 3 split；Stamen 4, the last 2,
Filigree top bifurcated, wherein one end raw flower pesticide；Ovary 4 is split, and style is thread.Pyrene brown, oblong, have 3 ribs.
Florescence 5～June.Really phase 6～July.It is born in wasteland, roadside and hillside thick grass.All there is distribution the greater part, the whole nation.
Herba Hemiboeae is the herb of Gesneriaceae Herba Hemiboeae.Autumn adopts, and dries.Former plant Herba Hemiboeae is perennial herb, high
20～30 centimetres.Base portion is thrown oneself on the ground, and has fibrous root.Stem four prismatic, dipped beam is sliding or micro-has fine, soft fur, has brownish black speckle.Leaf to life,
Oblong, long 10～20 centimetres, wide 6～10 centimetres, tip point, base portion is the narrowest, under to be extended down to the base portion of handle be narrow wing, entirely
Edge, above scattered white undercoat；Petiole length 2～3.5 centimetres.Spend 3～5 integrated nearly heads；Bennet top is raw or upper end axil is raw,
Long 2～3 centimetres, in 2 discrimination branches；Bract is circular；Calyx 6 splits, sliver lanceolar, is about 1 casket rice；The wide tubular of corolla,
Long 3～4 centimetres, the nearlyest 2 lip-like, lilac red；Stamen 2；Ovary is upper.Capsule is linear, long 2～4 centimetres.Florescence 8～9
Month.It is born in the dark and damp place of rock.The ground such as distribution Jiangsu, Zhejiang, Guizhou, Sichuan, Hunan, Hubei, Shaanxi.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine Spica Prunellae extract improving hen laying rate, this extract can significantly improve mother
Laying rate of chicken.
Above-mentioned purpose is achieved by following technical solution:
A kind of Chinese medicine Spica Prunellae extract improving hen laying rate, is prepared via a method which: (a) by dry Spica Prunellae and
Herba Hemiboeae mixes, and pulverizes, and with 65～75% ethanol solution circumfluence distillation, united extraction liquid, is concentrated into and obtains ethanol without alcohol taste and carry
Take concentrated solution；B (), by step (a) gained ethanol extraction concentrated solution dilute with water, uses petroleum ether, ethyl acetate and water successively
Saturated n-butanol extraction, concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and n-butyl alcohol extract；
C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first with 6～10% ethanol rush
Wash 7～9 column volumes and remove big polar components, then with 70～80% ethanol elution 13～17 column volumes, collection 70～80% ethanol
Eluent, concentrating under reduced pressure；Wherein, Herba Hemiboeae accounts for the 5%～15% of Spica Prunellae and Herba Hemiboeae gross weight.
Further, described Chinese medicine Spica Prunellae extract is prepared via a method which: (a) is by dry Spica Prunellae and Herba Hemiboeae
Mixing, pulverizes, with 70% ethanol solution circumfluence distillation, united extraction liquid, is concentrated into and obtains ethanol extraction concentrated solution without alcohol taste；
B (), by step (a) gained ethanol extraction concentrated solution dilute with water, uses petroleum ether, ethyl acetate and water saturated positive fourth successively
Alcohol extracts, and concentrating under reduced pressure respectively obtains petroleum ether extract, acetic acid ethyl ester extract and n-butyl alcohol extract；(c) n-butyl alcohol
Extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first removes with 8 column volumes of 8% alcohol flushing
Remove big polar component, then with 15 column volumes of 75% ethanol elution, collect 75% ethanol elution, concentrating under reduced pressure；Wherein,
Herba Hemiboeae accounts for the 10% of Spica Prunellae and Herba Hemiboeae gross weight.
Further, described Chinese medicine Spica Prunellae extract is prepared via a method which: (a) is by dry Spica Prunellae and Herba Hemiboeae
Mixing, pulverizes, with 65% ethanol solution circumfluence distillation, united extraction liquid, is concentrated into and obtains ethanol extraction concentrated solution without alcohol taste；
B (), by step (a) gained ethanol extraction concentrated solution dilute with water, uses petroleum ether, ethyl acetate and water saturated positive fourth successively
Alcohol extracts, and concentrating under reduced pressure respectively obtains petroleum ether extract, acetic acid ethyl ester extract and n-butyl alcohol extract；(c) n-butyl alcohol
Extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first removes with 9 column volumes of 6% alcohol flushing
Remove big polar component, then with 17 column volumes of 70% ethanol elution, collect 70% ethanol elution, concentrating under reduced pressure；Wherein,
Herba Hemiboeae accounts for the 5% of Spica Prunellae and Herba Hemiboeae gross weight.
Further, described Chinese medicine Spica Prunellae extract is prepared via a method which: (a) is by dry Spica Prunellae and Herba Hemiboeae
Mixing, pulverizes, with 75% ethanol solution circumfluence distillation, united extraction liquid, is concentrated into and obtains ethanol extraction concentrated solution without alcohol taste；
B (), by step (a) gained ethanol extraction concentrated solution dilute with water, uses petroleum ether, ethyl acetate and water saturated positive fourth successively
Alcohol extracts, and concentrating under reduced pressure respectively obtains petroleum ether extract, acetic acid ethyl ester extract and n-butyl alcohol extract；(c) n-butyl alcohol
Extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first with 7 column volumes of 10% alcohol flushing
Remove big polar component, then with 13 column volumes of 80% ethanol elution, collect 80% ethanol elution, concentrating under reduced pressure；Wherein,
Herba Hemiboeae accounts for the 15% of Spica Prunellae and Herba Hemiboeae gross weight.
The application in terms of improving hen laying rate of the above-mentioned Chinese medicine Spica Prunellae extract.
Advantages of the present invention:
The Chinese medicine Spica Prunellae extract preparation method improving hen laying rate that the present invention provides is simple, can industrialized production；This carries
Take thing and can significantly improve hen laying rate.
Detailed description of the invention
Further illustrate the essentiality content of the present invention below in conjunction with embodiment, but do not limit scope with this.To the greatest extent
The present invention is explained in detail by pipe with reference to preferred embodiment, it will be understood by those within the art that, can be to the present invention
Technical scheme modify or equivalent, without deviating from the spirit and scope of technical solution of the present invention.
Embodiment 1: the preparation of Spica Prunellae extract
A Spica Prunellae and Herba Hemiboeae (accounting for gross weight 10%) that 5kg is dried by () mix, and pulverize, with 70% ethanol solution hot reflux
Extract (20L × 3 time), united extraction liquid, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；B () is by step (a) institute
Ethanol extraction concentrated solution dilute with water (3L), successively with petroleum ether (3L × 3 time), ethyl acetate (3L × 3 time) and
Water saturated n-butanol extraction (3L × 3 time), concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and
N-butyl alcohol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first
Remove big polar component with 8 column volumes of 8% alcohol flushing, then with 15 column volumes of 75% ethanol elution, collect 75% ethanol
Eluent, concentrating under reduced pressure and get final product.
Embodiment 2: the preparation of Spica Prunellae extract
A Spica Prunellae and Herba Hemiboeae (accounting for gross weight 5%) that 5kg is dried by () mix, and pulverize, with 65% ethanol solution hot reflux
Extract (20L × 3 time), united extraction liquid, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；B () is by step (a) institute
Ethanol extraction concentrated solution dilute with water (3L), successively with petroleum ether (3L × 3 time), ethyl acetate (3L × 3 time) and
Water saturated n-butanol extraction (3L × 3 time), concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and
N-butyl alcohol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first
Remove big polar component with 9 column volumes of 6% alcohol flushing, then with 17 column volumes of 70% ethanol elution, collect 70% ethanol
Eluent, concentrating under reduced pressure and get final product.
Embodiment 3: the preparation of Spica Prunellae extract
A Spica Prunellae and Herba Hemiboeae (accounting for gross weight 15%) that 5kg is dried by () mix, and pulverize, with 75% ethanol solution hot reflux
Extract, united extraction liquid (20L × 3 time), be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；B () is by step (a) institute
Ethanol extraction concentrated solution dilute with water (3L), successively with petroleum ether (3L × 3 time), ethyl acetate (3L × 3 time) and
Water saturated n-butyl alcohol (3L × 3 time) extract, concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and
N-butyl alcohol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first
Remove big polar component with 7 column volumes of 10% alcohol flushing, then with 13 column volumes of 80% ethanol elution, collect 80% second
Alcohol eluen, concentrating under reduced pressure and get final product.
Embodiment 4: the contrast of embodiment 1, without Herba Hemiboeae
A Spica Prunellae that 5kg is dried by () is pulverized, with 70% ethanol solution circumfluence distillation (20L × 3 time), united extraction
Liquid, is concentrated into and obtains ethanol extraction concentrated solution without alcohol taste；(b) by step (a) gained ethanol extraction concentrated solution dilute with water (3L),
Successively with petroleum ether (3L × 3 time), ethyl acetate (3L × 3 time) and water saturated n-butanol extraction (3L × 3 time), subtract
Pressure concentrates, and respectively obtains petroleum ether extract, acetic acid ethyl ester extract and n-butyl alcohol extract；(c) n-butyl alcohol extract water
Dissolve, filter, with AB-8 type macroporous resin enrichment active component, first remove big polarity with 8 column volumes of 8% alcohol flushing and become
Point, then with 15 column volumes of 75% ethanol elution, collect 75% ethanol elution, concentrating under reduced pressure and get final product.
Embodiment 5: the contrast of embodiment 1, Herba Hemiboeae accounts for the 20% of gross weight
A Spica Prunellae and Herba Hemiboeae (accounting for gross weight 20%) that 5kg is dried by () mix, and pulverize, with 70% ethanol solution hot reflux
Extract (20L × 3 time), united extraction liquid, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；B () is by step (a) institute
Ethanol extraction concentrated solution dilute with water (3L), successively with petroleum ether (3L × 3 time), ethyl acetate (3L × 3 time) and
Water saturated n-butanol extraction (3L × 3 time), concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and
N-butyl alcohol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first
Remove big polar component with 8 column volumes of 8% alcohol flushing, then with 15 column volumes of 75% ethanol elution, collect 75% ethanol
Eluent, concentrating under reduced pressure and get final product.
Embodiment 6: the impact on hen laying rate
One, materials and methods
1, material: embodiment 1～5 is shown in the preparation of extract 1～5.
2, method
2.1 experimental animals and packet
Select the hen 120 being in a good state of health, be randomly divided into 6 groups, often group 20.Matched group uses Basic drawing to feed.
Test group 1～5 adds the extract 1～5 of embodiment 1～5 preparation of 800mg/kg respectively on the basis of Basic drawing respectively.
2.2 method for breeding
30 days test periods.Use routine to raise and immunity during whole test, free choice feeding, freely drink water.
2.3 test indexs and method
Egg production in adding up 30 days, by comparing with matched group, calculates the test group 1～5 increase rate of laying eggs relative to matched group.
Lay eggs increase rate=(test group egg production-matched group egg production)/matched group egg production
3, statistical analysis
Test data uses SPSS20.0 software to carry out variance analysis, and the significance of difference carries out Duncans multiple comparisons, number in table
Value is expressed as Mean ± SD.
Two, result
The results are shown in Table 1.
As shown in Table 1, the increase rate increase rate of laying eggs apparently higher than test group 4 and 5 of laying eggs of test group 1～3.Test group 4
With 5 increase rate difference compared with test group 1 of laying eggs there is significance (P ＜ 0.05).
Hen is laid eggs the impact of increase rate by table 1 extract
| Group | Increase rate of laying eggs (%) |
| Test group 1 | 18% |
| Test group 2 | 16% |
| Test group 3 | 16% |
| Test group 4 | 3% |
| Test group 5 | 2% |
Result shows, the extract that the present invention provides can significantly improve the egg laying performance of hen.
The above-mentioned effect of extract of the present invention is relevant with the addition whether adding Herba Hemiboeae and Herba Hemiboeae.
The effect of above-described embodiment indicates that the essentiality content of the present invention, but does not limit protection scope of the present invention with this.
It will be understood by those within the art that, technical scheme can be modified or equivalent, and not take off
Essence and protection domain from technical solution of the present invention.
Claims (5)
1. the Chinese medicine Spica Prunellae extract improving hen laying rate, it is characterised in that be prepared via a method which: (a)
Dry Spica Prunellae and Herba Hemiboeae are mixed, pulverizes, with 65～75% ethanol solution circumfluence distillation, united extraction liquid, be concentrated into
Taste without alcohol obtains ethanol extraction concentrated solution；B (), by step (a) gained ethanol extraction concentrated solution dilute with water, uses oil successively
Ether, ethyl acetate and water saturated n-butanol extraction, concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract
And n-butyl alcohol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component,
First with 6～10% alcohol flushing 7～9 column volumes remove big polar components, then with 70～80% ethanol elution 13～17 column volumes,
Collection 70～80% ethanol elution, concentrating under reduced pressure；Wherein, Herba Hemiboeae accounts for the 5%～15% of Spica Prunellae and Herba Hemiboeae gross weight.
Chinese medicine Spica Prunellae extract the most according to claim 1, it is characterised in that be prepared via a method which: (a)
Dry Spica Prunellae and Herba Hemiboeae are mixed, pulverizes, with 70% ethanol solution circumfluence distillation, united extraction liquid, be concentrated into nothing
Alcohol taste obtains ethanol extraction concentrated solution；(b) by step (a) gained ethanol extraction concentrated solution dilute with water, successively with petroleum ether,
Ethyl acetate and water saturated n-butanol extraction, concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and just
Butanol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first uses
8% alcohol flushing 8 column volume removes big polar component, then with 15 column volumes of 75% ethanol elution, collects 75% ethanol and wash
De-liquid, concentrating under reduced pressure；Wherein, Herba Hemiboeae accounts for the 10% of Spica Prunellae and Herba Hemiboeae gross weight.
Chinese medicine Spica Prunellae extract the most according to claim 1, it is characterised in that be prepared via a method which: (a)
Dry Spica Prunellae and Herba Hemiboeae are mixed, pulverizes, with 65% ethanol solution circumfluence distillation, united extraction liquid, be concentrated into nothing
Alcohol taste obtains ethanol extraction concentrated solution；(b) by step (a) gained ethanol extraction concentrated solution dilute with water, successively with petroleum ether,
Ethyl acetate and water saturated n-butanol extraction, concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and just
Butanol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first uses
6% alcohol flushing 9 column volume removes big polar component, then with 17 column volumes of 70% ethanol elution, collects 70% ethanol and wash
De-liquid, concentrating under reduced pressure；Wherein, Herba Hemiboeae accounts for the 5% of Spica Prunellae and Herba Hemiboeae gross weight.
Chinese medicine Spica Prunellae extract the most according to claim 1, it is characterised in that be prepared via a method which: (a)
Dry Spica Prunellae and Herba Hemiboeae are mixed, pulverizes, with 75% ethanol solution circumfluence distillation, united extraction liquid, be concentrated into nothing
Alcohol taste obtains ethanol extraction concentrated solution；(b) by step (a) gained ethanol extraction concentrated solution dilute with water, successively with petroleum ether,
Ethyl acetate and water saturated n-butanol extraction, concentrating under reduced pressure, respectively obtain petroleum ether extract, acetic acid ethyl ester extract and just
Butanol extract；C () n-butyl alcohol extract water dissolution, filters, with AB-8 type macroporous resin enrichment active component, first uses
10% alcohol flushing 7 column volume removes big polar component, then with 13 column volumes of 80% ethanol elution, collects 80% ethanol and wash
De-liquid, concentrating under reduced pressure；Wherein, Herba Hemiboeae accounts for the 15% of Spica Prunellae and Herba Hemiboeae gross weight.
5. Claims 1 to 4 arbitrary described Chinese medicine Spica Prunellae extract application in terms of improving hen laying rate.
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