CN105963338A - Traditional Chinese herbal medicine composition for preventing and treating cervical erosion - Google Patents
Traditional Chinese herbal medicine composition for preventing and treating cervical erosion Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
Abstract
The invention relates to a gynecological traditional Chinese herbal medicine composition, and particularly relates to a traditional Chinese herbal medicine composition for preventing and treating cervical erosion. The traditional Chinese herbal medicine composition is prepared from the following traditional Chinese herbal medicinal materials in parts by weight: 60-90 parts of dioscorea althaeoides, 10-20 parts of charcoaled eucommia ulmoides, 10-40 parts of calcined concha arcae, 3-6 parts of angelica polymorpha maxim, 2-12 parts of trifoliate acanthopanax root root-bark, 2-11 parts of pterocephalus hookeri heck and 1-2 parts of phoenix tree seeds. Test researches on itching-relieving, pain-relieving, inflammation-diminishing and bacteria-inhibiting indicate that the traditional Chinese herbal medicine composition has a remarkable effect; impact test researches on a cervical erosion model rat discovers that a model set has infiltrated and thickened vagina mucosa epithelial inflammatory cells, and inflammatory cell infiltration of rats in the test set are remarkably reduced, and the area of uterine mucosa erosion is remarkably reduced than that of anti-cervical erosion suppository. Those researches indicate that the traditional Chinese herbal medicine composition has a remarkable treatment effect on a cervical erosion model rat, and has the effect superior to that of the prior art.
Description
Technical field
The present invention relates to a kind of gynecological herbal composite, a kind of Chinese herbal medicine combination preventing and treating cervical erosion
Thing.
Background technology
The physiological structure feature of vagina determines its infection being highly susceptible to exogenous virus and pathogen bacteria,
So that a lot of women are suffering from cervical disease in various degree, such as vulvitis, cervicitis, bacterial vaginosis, cervical erosion
And mycotic, trichomonas and nonspecific vaginitis even cervical cancer, ovarian cancer etc..Wherein, cervical erosion is cervical disease
Middle commonly encountered diseases, frequently-occurring disease, be the one of the main reasons of induction cervical cancer.Cervical erosion not only increases patient suffering, and seriously
Affect the Health and Living quality of women.
At present, the treatment of cervical erosion is divided into physiotherapy and pharmacotherapy.Naturopathy is to apply the most at present
A kind of Therapeutic Method, has short treating period, eutherapeutic advantage.It is applicable to the patient that rotten to the corn area is relatively big and inflammatory infiltration is deeper.
Conventional method has electric rubbing hot medicated compress, laser therapy, cryotherapy.Tradition leep knife (LEEP), focusing ultrasound wave, micro-wave therapeutic, TMS
Optimizing chromophototherapy, freezing, electron ion, carbon dioxide laser etc., the principle great majority for the treatment of are to utilize heat effect or cold effect
The histone degeneration making cervical erosion comes off, instead cambium.Thus result in the cervical erosion wound after treatment big, palace
Neck head is stiff, nonelastic, allows patient by secondary injury, impact fertility, and as recurred unrenewable physical therapy treatment, pair is treated
Greatly.Drug therapy is applicable to the rotten to the corn patient that area is less and inflammatory infiltration is shallower.Medicine is broadly divided into Western medicine, Chinese medicine, and
Chinese medicine and western medicine is worked in coordination with.But current Drug therapy, generally exists that weak curative effect, secondary treatment be big, the easy weak point such as recurrence after treatment.
Summary of the invention
The problem that it is an object of the invention to there is prior art is solved, it is provided that it is rotten that one can effectively prevent and treat cervix uteri
Rotten herbal composite, to be reduced or eliminated the cervical erosion harm to WomanHealth.
The herbal composite preventing and treating cervical erosion of the present invention, is made up of the Chinese herbal medicine of following portions by weight: river
Pheretima 60-90, charred Cortex Eucommiae 10-20, Concha Arcae (calcined) 10-40, Radix Pternopetali vulgaris 3-6, Radix Acanthopanacis Trifoliati 2-12, Herba pterocephali 2-11, Chinese parasol tree
Seeds of a tung oil tree 1-2.
Preferably it is made up of the Chinese herbal medicine of following portions by weight:
Valley dragon 75-85, charred Cortex Eucommiae 15-20, Concha Arcae (calcined) 15-30, Radix Pternopetali vulgaris 3-5, Radix Acanthopanacis Trifoliati 5-10, Herba pterocephali 6-
9, Semen Firmianae 1-2.
More preferably it is made up of the Chinese herbal medicine of following portions by weight:
Valley dragon 75, charred Cortex Eucommiae 17, Concha Arcae (calcined) 17, Radix Pternopetali vulgaris 5, Radix Acanthopanacis Trifoliati 9, Herba pterocephali 9, Semen Firmianae 2.
The preparation method of the herbal composite preventing and treating cervical erosion of the present invention, comprises the steps:
(1) prepare each raw material the most dried, weigh each raw material by weight, standby；
(2) raw material weighed in step (1) mixing being inserted in decoction still, add deionized water, big fire decocts 30-45min,
Slow fire boiling 2-3h again, 200 mesh filters filter decocting liquid, collect filtrate, are concentrated into ointment shape in vaporizer.
Preferably, described herbal composite is external preparation, can be in gel, ointment, suppository or cleanout fluid
Any one.
Herbal composite of the present invention is by antipruritic, analgesia, antiinflammatory, bacteriostatic test research display, institute of the present invention
State herbal composite to have a significant effect, and found by the experimental study that affects of cervical erosion rat model, model group
All occur that vaginal mucosal epithelium inflammatory cell invades profit, thicken；Rats in test groups inflammatory cell is invaded profit and is substantially alleviated, and uterine mucosa is rotten to the corn
Area relatively XIAOMI SHUAN is obviously reduced；This illustrates the herbal composite of the present invention therapeutical effect to cervical erosion rat model
Significantly, effect is superior to prior art.
Detailed description of the invention
Experimental example 1
1, valley dragon 65g, charred Cortex Eucommiae 12g, Concha Arcae (calcined) 15g, Radix Pternopetali vulgaris 3g, Radix Acanthopanacis Trifoliati 3g, Herba pterocephali 3g, Semen Firmianae are prepared
1g。
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, and 200 mesh filters filter decocting liquid, collect filtrate, in evaporation
Device is concentrated into ointment shape.
Experimental example 2
1, valley dragon 90g, charred Cortex Eucommiae 20g, Concha Arcae (calcined) 35g, Radix Pternopetali vulgaris 5g, Radix Acanthopanacis Trifoliati 10g, Herba pterocephali 10g, Semen Firmianae are prepared
2g。
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, and 200 mesh filters filter decocting liquid, collect filtrate, in evaporation
Device is concentrated into ointment shape.
Experimental example 3
1, valley dragon 75g, charred Cortex Eucommiae 15g, Concha Arcae (calcined) 15g, Radix Pternopetali vulgaris 3g, Radix Acanthopanacis Trifoliati 5g, Herba pterocephali 6g, Semen Firmianae are prepared
1g。
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, and 200 mesh filters filter decocting liquid, collect filtrate, in evaporation
Device is concentrated into ointment shape.
Experimental example 4
1, valley dragon 85g, charred Cortex Eucommiae 20g, Concha Arcae (calcined) 30g, Radix Pternopetali vulgaris 5g, Radix Acanthopanacis Trifoliati 10, Herba pterocephali 9g, Semen Firmianae are prepared
2g。
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, and 200 mesh filters filter decocting liquid, collect filtrate, in evaporation
Device is concentrated into ointment shape.
Experimental example 5
1, valley dragon 75g, charred Cortex Eucommiae 17g, Concha Arcae (calcined) 17g, Radix Pternopetali vulgaris 5g, Radix Acanthopanacis Trifoliati 9g, Herba pterocephali 9g, Semen Firmianae are prepared
2g。
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, and 200 mesh filters filter decocting liquid, collect filtrate, in evaporation
Device is concentrated into ointment shape.
Experimental example 6
One, on the impact of Cavia porcellus itch-threshold caused by histamine phosphate
Test method and result:
1. animal packet: Cavia porcellus 50, body weight 250-300g, female.It is randomly divided into 5 groups, often group 10, i.e. Chinese medicine composition
Thing low dose group (1g/100mL), middle dosage group (5g/100mL), high dose group (10g/100mL), FUFANG HUANGSONG XIYE group is (former
Liquid), and blank group (0.4% sodium carboxymethyl cellulose).
2. instep behind matched group Cavia porcellus, FUFANG HUANGSONG XIYE group Cavia porcellus, the Chinese medicine composition basic, normal, high dosage group Cavia porcellus right side
Shaving is also coated with relative medicine 1 time, and shaving area is about 1cm2, and coating capacity is about 0.2ml, uses mouse stomach pin
Head is coated in skin of unhairing surface equably, contacts 4 hours with gauze parcel immobilization with adhesive tape；Second day matched group, compound recipe yellow pine
Behind washing liquid group, the Chinese medicine composition basic, normal, high dosage group Cavia porcellus right side, instep all abrades with coarse sandpaper, with oozing of blood for degree, and is coated with phase
Answering medicine 1 time, coating capacity is about 0.2ml, is coated in skin of unhairing surface equably with mouse stomach syringe needle；30 points
Zhong Hou, cleans wound surface, dries affected part with gauze gently, repaste the histamine phosphate of concentration 0.02%, every three minutes once, often
Secondary being 0.05ml/ only, until occurring when Cavia porcellus licks metapedes, the histamine phosphate total amount that record gives is itch-threshold, respectively organizes Cavia porcellus
Itch-threshold see table:
Table 1: the herbal composite impact on histamine phosphate induced mice itch-threshold
As can be seen from the above table, outside a good appetite suddenly appearing in a serious disease herbal-composition low dose group, the herbal composite of middle and high dosage group and compound recipe are yellow
Pine washing liquid group all can improve Cavia porcellus itch-threshold caused by histamine phosphate, illustrates that this medicine has obvious itching-relieving action.
Two, the impact (writhing method) on mice analgesic activity:
1. animal packet: mice, 60, Kunming kind 18-22g, female.Animal is randomly divided into 6 groups, often group 10, i.e.
Herbal composite basic, normal, high dosage group, dolantin group, model group and matched group.
2. observation index: model group and matched group give 0.4% sodium carboxymethyl cellulose, other respectively organize equal vagina to
Give relative medicine 0.2ml, close vaginal orifice with vaseline；After being administered 60 minutes, except matched group intraperitoneal injection of saline,
Each Mus equal lumbar injection 0.6% acetic acid 0.2ml, in observing 10 minutes, each group there is writhing response mice number of elements (abdominal part
Indent, stretching, extension hind leg, buttocks are raised) and number of times, result see table.
The impact on mice analgesic activity of table 2 herbal composite
As can be seen from the above table, lumbar injection 0.6% glacial acetic acid can cause mice and pain reaction occurs, illustrates that modeling is successful,
Herbal composite and the dolantin of basic, normal, high dosage group can obviously reduce mouse writhing quantity, illustrate that this medicine has obvious town
Pain effect.
Three, the impact (auricle edema method) on mouse corrosion disease effect
1. animal packet: mice, 60, Kunming kind 18-22g, female.Animal is randomly divided into 6 groups, often group 10, i.e.
Herbal composite basic, normal, high dosage group, prednisone group, FUFANG HUANGSONG XIYE group and matched group.
2. observation index: matched group give 0.4% sodium carboxymethyl cellulose-+, other are respectively organized equal vagina and give accordingly
Medicine 0.2ml, closes vaginal orifice with vaseline；Within 30 minutes, rear left auricle is only coated with 100% dimethylbenzene 0.02ml/, 4 hours
After, mice is pulled cervical vertebra and puts to death, cut two ears along auricle baseline, lay circle at same position respectively with the straight card punch of 8mm
Auricle, torsion balance is weighed；Every left auricle of Mus deducts auris dextra tablet weight and is swelling.Result see table.
The impact on mice auricle swelling of table 3 herbal composite
As can be seen from the above table, mice auricle swelling degree is had substantially by herbal composite and the prednisone of basic, normal, high dosage group
Alleviate, i.e. xylol induced mice auricle inflammation has obvious inhibitory action.
Four, on the impact of rat bacterial vaginitis caused by S. aureus L-forms
Test objective: add inoculation S. aureus L-forms by injury rats vaginal wall and cause rat vagina inflammation model, give medicine,
Observe medicine to integral status, vaginal congest edema, vaginal smear examination leukocyte and the antibacterial of animal and pathological examination results
Change, weigh the medicine therapeutical effect to bacterial vaginitis.
1. animal packet: animal is randomly divided into 6 groups, often group 10, the i.e. basic, normal, high dosage of herbal composite
Group, FUFANG HUANGSONG XIYE group, model group and Normal group.
2. observation index: each group rat all draws 30 with No. 7 blunt syringe needles the most every Mus
Secondary, by one man operation, to ensure dynamics uniformity, in addition to matched group, other are respectively organized and all inject 108/L S. aureus L-forms liquid
0.2ml, seals vaginal orifice with vaseline；Within second day, in addition to matched group, remaining is respectively organized and all sees under mirror that obvious WBC increases, smear
In have a large amount of S. aureus L-forms, vaginal secretions increases, and vaginal mucosa is congested, swelling, and surface is coated with white thing；Within 3rd day, rise, right
Giving 0.4% sodium carboxymethyl cellulose according to group, other are respectively organized equal vagina and give relative medicine 0.2ml, close vagina with vaseline
Mouthful；The integrality of each treated animal of perusal every day, vagina are with or without in congested swelling, and its vaginal secretions of plate coating checking
Inflammatory cell and antibacterial, make vaginal secretions smear after within the 7th day, being administered 5 hours, see WBC and S. aureus L-forms；De-cervical vertebra is put to death big
Mus, takes out its vagina, observes its vaginal mucosa with or without congested, edema situation, then is put into by vagina in BolinShi fixative,
Send and do check pathological section；
3, formulation vaginitis therapeutic evaluation is with the pathological changes gross examination of skeletal muscle of vagina tissue as criterion, see table.
Table 4 S. aureus L-forms vaginitis rat standards of grading
3, result:
(1) vagina local patholoic change perusal: after rat moulding, the most congested, swelling, secretion occur in the 1-3 days vaginas
Thing rolls up, and surface covers a large amount of white sticky secretions.At the 1-3 days vaginal secretions smears, it is seen that have substantial amounts of
Inflammatory cell and S. aureus L-forms, comprehensive scores between each group set up by model does not has notable difference.Within 3rd day, start to be administered in modeling, big or middle
Dosage group was in being administered the 3rd day, and vagina contrafluxion, edema, secretions, mucosal erosion alleviate, and had slight in 4-5 days
Congested swelling, remaining all recovers normal except having mild hyperaemia swelling individually for the 7th day vagina pathological changes, comprehensive scores and model group,
Matched group compares pole significant difference.Small dose group and positive drug group pathological changes in time being administered 4-5 days the most substantially alleviates, the 7th
My god, the most basic recovery of vagina local patholoic change is normal, and comprehensive scores compares with model group, Normal group also has inspection significance poor
Different, it is specifically shown in following table.
The impact on S. aureus L-forms vaginitis pathological changes comprehensive scores of table 5 herbal composite
(2) vaginal smear examination: after each assembly molding, vaginal secretions smear is all positive, it is seen that have substantial amounts of S. aureus L-forms and take off
Fall epithelial cell and inflammatory cell.After administration the 7th day, there is S. aureus L-forms and a large amount of seen from model group 10 example, Normal group 0 example smear
Inflammatory cell and downright bad Exfoliative cells.You Jin Portugal seen from administration group a good appetite suddenly appearing in a serious disease herbal-composition small dose group 3 example and positive drug
Outside bacterium, herbal composite big-and-middle dosage group only 1 and 2 examples have a S. aureus L-forms, rarely seen have a small amount of inflammatory cell and come off upper
Chrotoplast, concrete condition see table.
The table 6 impact on vaginal secretions smear (WBC and S. aureus L-forms)
(3) histological examination: matrix group each layer tissue structure is normal, epithelium is without breakage, rotten to the corn, and mucosa has no congested and water
Swollen, tela submucosa and muscle layer no abnormality seen；There is obvious congestion and edema, epithelium visible portions in model group vaginal mucosa lower floor and muscle layer
Divide incompleteness；Low dose group mucosa and tela submucosa congestion and edema alleviate, and have 1 example epithelium incomplete；Middle dosage group partial rat is cloudy
Road mucosa visible hyperemia swelling, portion weave structure recovers normal；High dose group rat portions vaginal mucosa has mild hyperaemia water
Swollen, portion weave structure recovers normal completely；Positive drug group rat portions vaginal mucosa has mild hyperaemia edema, and portion of tissue is tied
Structure recovers normal completely.
Five, the impact on cervical erosion rat model
Healthy female rat 48, is randomly divided into blank group, model control group, positive controls, test group.Take phenol
30mL, arabic gum 40g, distilled water 50mL are made into Hydroxybenzene mucilage, enter people's rat vagina with taper venotomy pin and inject phenol
Rubber cement 0.2mL, 1 time/3 days, totally 4 times.After modeling success, start drug treatment.The mode of each group rat according to the form below is given
Give tested material.
Table 7 is grouped and administering mode
Each group is administered once/sky, successive administration 7 days, within the 8th day, puts to death animal, take its vagina, uterus perusal and carry out pathology
Histological examination.
Dissecting rat and take uterine cancer cell perusal, model control group rat vagina, cervical tissue are congested, edema.Treatment
Group all has a certain degree of improvement.Pathologic finding, vagina and the uterine cancer cell of blank group rat have no obvious pathological changes, model
Group all occurs that vaginal mucosal epithelium inflammatory cell invades profit, thickens.Rats in test groups inflammatory cell is invaded profit and is substantially alleviated, and uterine mucosa is rotten
Rotten area relatively XIAOMI SHUAN is obviously reduced.The therapeutical effect of cervical erosion rat model is shown by the Chinese medicine suppository of this explanation present invention
Write, be better than prior art.Concrete outcome see table.
The table 8 pathological examination to uterine erosion rat model
Claims (3)
1. prevent and treat the herbal composite of cervical erosion, it is characterised in that be made up of the Chinese herbal medicine of following portions by weight: valley dragon
60-90, charred Cortex Eucommiae 10-20, Concha Arcae (calcined) 10-40, Radix Pternopetali vulgaris 3-6, Radix Acanthopanacis Trifoliati 2-12, Herba pterocephali 2-11, Semen Firmianae
1-2.
Prevent and treat the herbal composite of cervical erosion the most as claimed in claim 1, it is characterised in that by following portions by weight
Chinese herbal medicine forms: valley dragon 75-85, charred Cortex Eucommiae 15-20, Concha Arcae (calcined) 15-30, Radix Pternopetali vulgaris 3-5, Radix Acanthopanacis Trifoliati 5-10, the wing
First grass 6-9, Semen Firmianae 1-2.
Prevent and treat the herbal composite of cervical erosion the most as claimed in claim 2, it is characterised in that by following portions by weight
Chinese herbal medicine forms: valley dragon 75, charred Cortex Eucommiae 17, Concha Arcae (calcined) 17, Radix Pternopetali vulgaris 5, Radix Acanthopanacis Trifoliati 9, Herba pterocephali 9, Semen Firmianae 2.
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| CN102526342A (en) * | 2012-02-02 | 2012-07-04 | 李坤 | Traditional Chinese medicine preparation for treating chronic cervicitis |
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| CN102526342A (en) * | 2012-02-02 | 2012-07-04 | 李坤 | Traditional Chinese medicine preparation for treating chronic cervicitis |
Non-Patent Citations (3)
| Title |
|---|
| 张佃民: "带下治验两则", 《山东医药》 * |
| 李应存等: "近年来中医药治疗子宫颈癌的概况", 《甘肃中医》 * |
| 汪植等: "土家族药紫金砂的生药学研究", 《时珍国医国药》 * |
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