CN105962359A - Composition with function of assisting in improving memory - Google Patents
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- CN105962359A CN105962359A CN201610305177.1A CN201610305177A CN105962359A CN 105962359 A CN105962359 A CN 105962359A CN 201610305177 A CN201610305177 A CN 201610305177A CN 105962359 A CN105962359 A CN 105962359A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of health-care foods, and discloses a composition with the health-care function of assisting in improving memory. The components of the composition are a mixture of the following raw materials in parts by weight, or an extract made from the following raw materials in parts by weight: 20-160 parts of a raw material A in which the mass content of total saponins is higher than 1%, 100-4000 parts of a raw material B in which the mass content of anthocyanidin type polyphenol is higher than 0.1%, 10-100 parts of a raw material C in which the mass content of DHA is higher than 10%, and 50-400 parts of a raw material D in which the mass content of alpha-linolenic acid is higher than 30%. According to the composition disclosed by the invention, common foods, medicinal and edible natural plants, and natural plants which can be used as health-care foods are used as raw materials, the composition is rich in traditional Chinese medicine active components such as saponins, oxidation resistant factors such as anthocyanin, and nutrient components for brains, such as DHA, and the composition can be prepared into the health-care foods of different preparation formulations; researches indicate that the composition is safe, free from toxic and side effects and suitable for being eaten for a long term, and has the health-care function of assisting in improving memory.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of compositions with auxiliary improving memory function.
Background technology
Cognitive and memory is the nervous process that brain is most important and basic, and the aging of age generally all can be along with under memory function
Fall, research thinks that this phenomenon originates from the change of nerve synapse.Though the cognitive competence that the age is correlated with declines the most significantly
The daily life that impact is actual, but a certain degree of cognitive decline still can reduce quality of life, reduces person-to-person exchange.Part
Age relevant memory decline can along with nerve regression gradually develop into Alzheimer (Alzheimer disease,
AD), the development along with the state of an illness can gradually lose independent self-care ability.As common vascular conditions the most all over the world
The obstacle of brain function can be caused equally, mainly show as depolarization around the infarct that ischemia causes, inflammation, apoptotic dead
The aspect such as die.And the diabetes ranking the third-largest disease have been found that the infringement of cognitive function of patients in nineteen twenty-two, it is mainly it right
It is caused that central nervous system produces damage.It addition, unbalanced, tired, the cold and oxygen deficient of meals etc. can cause cognitive and memory equally
The decline of function.
In China's Chinese medicine, early there is the relevant record of amnesia, as " dialectical record. forgetful door " it is loaded with that " people has old
And forgetter, nearly thing is many not to be remembered, though people states front thing, if still ignorant, this most forgetful pole is also " description.Comprehensive forefathers'
Discussing, Chinese medicine learning memory function declines can be attributed to void, silt, three aspects of expectorant.Void is function and goes down, essence
Insufficiency of vital energy and blood；Become silted up and hinder heart and brain, irritability, palpitation and insomnia, forgetful dementia, the quiet language of coma for addiction；Expectorant is the turbid upper criminal's head of expectorant
Portion, blinds clear sun, brain god's apraxia.The Chinese crude drug of Fructus Alpiniae Oxyphyllae class, sees at Gui Jingshang, it can be observed that certain tropism, mainly
GUIXIN, spleen, kidney, the particularly heart, kidney two warp, enter liver, lung two through less, and this also illustrates in theory of Chinese medical science, and heart spleen kidney exists
In Fructus Alpiniae Oxyphyllae significant, also dirty with the three physiological and pathological status of this discussion is inseparable.
For China, by the end of the year 2013,60 one full year of life and above population about 200,000,000, account for the 14.9% of total population, 65 one full year of life
And above population about 1.3 hundred million, account for the 9.7% of total population, step into aging society already, the Memory and Cognition obstacle that the age is relevant
Dramatically increasing occurs in number.For modal i.e. Alzheimer, the AD annual report of 2015 is pointed out, the whole world
AD patient has reached 46,800,000 people, and China belongs to AD region occurred frequently, it is contemplated that be likely to be breached 20,000,000 people to the middle of this century
Number.Vascular type brain injury is the common frdquently encountered disease of person in middle and old age equally, and the sickness rate in developed country is only second to AD, domestic nearly two
The sickness rate of the epidemiology display recent two decades domestic vascular brain injury over 10 years gradually rises, and along with the increase at age
Notable growth.And in domestic more than 20 years old crowd the prevalence of diabetes oneself reach 10%, total number of patients reaches more than 92,000,000,
Estimate that more than 60 years old age group prevalence is more than 20%.
Chinese invention patent publication number CN102886041A discloses a kind of compositions improving memory and preparation method thereof, with eight
Herba mesonae chinensis, Folium Angelicae, Ramulus Populi Davidianae, Cortex Cinnamomi, Fructum Artemisiae Argyi and fishbone polypeptide are the active component that raw material is made, and commonly use adjuvant system with medicine
Become oral formulations；This inventive composition can improve memory.Chinese invention patent publication number CN103445148A discloses one
Compositions improving memory and preparation method thereof, this food compositions is by soybean lecithin, Folium Ginkgo, Radix Ginseng, Herba Lycopodii serrati
Make Deng raw material.
Improve memory class product predominantly Chinese medicine, Western medicine and both combinations at present to be combined.Western medicine class mainly includes acting on gallbladder
Alkali energy system, cerebral metabolism, calcium ion antagonist, neurotrophic agent etc., but this kind of Western medicine majority belongs to medicine,
There is certain side effect and be not suitable for long-term taking, and part Chinese medicine equally exists the problems referred to above, such as the portion related in above-mentioned patent
Point raw material is not the raw material of bread and cheese or integration of edible and medicinal herbs, in some instances it may even be possible to there is toxic and side effects.Additionally it is worth mentioning that now
More Chinese medicine series products functional component obscures, and mechanism of action is more single, and adaptation population has the most restricted.Accordingly, it would be desirable to
Develop a kind of energy long-term taking, functional component is clear and definite, cover the product that crowd is wider.
Summary of the invention
The present invention is directed to the deficiency of above-mentioned prior art existence and a kind of compositions with auxiliary improving memory function is provided, this group
Compound raw material can have clear and definite functional component as food consumption, carries out improving reparation to memory from number of ways, has peace
The advantages such as complete suitable long-term taking, the crowd that covers are wide.
The present invention solves that the technical scheme that the deficiency of above-mentioned existence is used is:
A kind of compositions with auxiliary improving memory function, its component is mainly the mixture of following raw materials in part by weight or is somebody's turn to do
Extract prepared by raw material: Total saponin mass content higher than 1% raw material A 20～160 parts, anthocyan polyphenol matter
Amount content higher than 0.1% raw material B 100～4000 parts, DHA mass content higher than 10% raw material C 10～100 parts, α-
The linolenic acid mass content raw material D 50～400 higher than 30%.
Preferably, described in there is the compositions of auxiliary improving memory function, its component be following raw materials in part by weight mixture
Or extract prepared by this raw material: Total saponin mass content higher than 1% raw material A 40～160 parts, anthocyan
Polyphenol mass content higher than 0.1% raw material B 1000～4000 parts, DHA mass content higher than 10% raw material C 20～100
Part, alpha-linolenic acid mass content higher than 30% raw material D 100～400 parts.
By such scheme, the described Total saponin mass content raw material A higher than 1% can be selected from Radix Ginseng, Radix Pseudostellariae, Radix Codonopsis, west
Any one or a few mixture in any proportion in Radix Panacis Quinquefolii, Radix Polygalae etc..
By such scheme, the described anthocyan polyphenol mass content raw material B higher than 0.1% can be selected from Pericarpium Citri tangerinae, blue berry, Mulberry
Any one or a few mixture in any proportion in Shen etc..
By such scheme, the described DHA mass content raw material C higher than 10% can be selected from algae oil, fish oil etc. any one
Or several mixture in any proportion.
By such scheme, the described alpha-linolenic acid mass content raw material D higher than 30% can be selected from Semen Lini oil, Oleum Perillae
Any one or a few mixture in any proportion in Deng.
By such scheme, described raw material C (algae oil and or fish oil etc.) or raw material D (Semen Lini oil and or Oleum Perillae etc.)
Can the raw material of corresponding fat content substitute, i.e. algae oil uses with the algae powder of corresponding fat content, and Semen Lini oil is with right
The Semen Lini oil answering fat content uses.
By such scheme, described raw material A (Radix Ginseng and or Radix Pseudostellariae and or Radix Codonopsis and or Radix Panacis Quinquefolii and or Radix Polygalae etc.) or raw material
B (Pericarpium Citri tangerinae and or blue berry and or Fructus Mori etc.) is prepared as dry powder and uses.The acquisition pattern of described dry powder includes following three kinds:
One is, raw material is through being dried, pulverizing the dry powder obtained；Two are, raw material, after the extraction of water or alcohol equal solvent, concentrates dry
Dry obtained dry powder；Three are, raw material, after water or alcohol equal solvent extract, concentrates and purifies refined obtained dry of being dried
Powder.
Preferably, raw material A is with the ethanol solution of mass fraction 70-90%, solid-liquid ratio 1:(5-7) if, temperature 70-80 DEG C carries out
Extracting for dry time, 1-2h/ time, extracting solution is spray-dried after concentrating and obtains dry powder.
Preferably, raw material B is with the ethanol solution of mass fraction 40-70%, solid-liquid ratio 1:(7-9) if, temperature 65-75 DEG C carries out
Extract for dry time time, 1-2h/ time；Gained extracting solution crosses macroporous resin after concentrating, with mass fraction 30-70% ethanol solution eluting,
Collecting eluent, concentrated spray is dried acquisition dry powder.
By such scheme, described raw material C (algae oil and or fish oil etc.) or raw material D (Semen Lini oil and or Oleum Perillae etc.)
In oils and fats can be prepared as microcapsule powder, will raw material C or raw material D carry out embedding process obtain microcapsule powder.
Preferably, raw material C is using arabic gum, maltodextrin 1:(2-4 in mass ratio) mixing is as wall material, core, wall material
Carrying out emulsifying embedding (such as mass ratio (1-2): 1) by a certain percentage, gained LS is dried and prepares microcapsule powder.
Preferably, raw material D is using arabic gum, maltodextrin, soybean protein 1.5:(3-5 in mass ratio): (3-5) mixes as wall
Material, core, wall material (1-3) in mass ratio: 1 carries out emulsifying embedding, LS is dried and prepares microcapsule powder.
The preparation technology of the compositions with auxiliary improving memory function of the present invention, by raw material A, the powder of raw material B and former
Material C, the microcapsule powder of raw material D directly mix the compositions i.e. obtaining having auxiliary improving memory function.Or, institute of the present invention
State the preparation technology of the compositions with auxiliary improving memory function, by raw material A, the powder of raw material B and raw material C, raw material D
Directly mixing i.e. obtains the compositions with auxiliary improving memory function.
The compositions with auxiliary improving memory function of the present invention can make powder, granule, hard capsule, soft capsule,
The oral thing of the dosage forms such as ordinary tablet, dispersible tablet, buccal tablet, chewable tablet, oral liquid.
The compositions with auxiliary improving memory function of the present invention is as the raw material in oral thing and the absorption of functional component every day
Within the scope of amount should be at the absorption of country's relevant regulations.
The present invention also provides for a kind of product, and this product is health food, and this product includes that what adjuvant and the present invention provided has auxiliary
Improve the compositions of memory function.Specifically, have described in auxiliary improving memory function compositions can with conventional pharmaceutical on can
On the adjuvant accepted or bromatology, acceptable adjuvant makes powder, granule, hard capsule, soft capsule, ordinary tablet, dispersion
The oral thing of the dosage forms such as sheet, buccal tablet, chewable tablet, oral liquid.
The present invention is with bread and cheese, medicine-food two-purpose and can be used for the natural plants of health food as raw material, develops one and has
The compositions of auxiliary improving memory function, this combination is rich in necessary in active ingredient of Chinese herbs Saponin, Antioxidative Factors anthocyanin and brain
Nutritional labeling DHA, can be from the more comprehensive auxiliary improvement of memory of multipath.The raw materials such as Radix Ginseng in the present invention, Radix Polygalae, contain
Some Total saponin have the biological activity such as resisting fatigue, enhancing body adaptation ability, in terms of nervus centralis, can carry out emerging to it
Put forth energy, the regulation of process of inhibition, and memory can be improved and repairs；Wherein Radix Ginseng total saponins can improve the work of antioxidase
Property, reduce the peroxidation of lipid, suppress the accumulation of mitochondrial decay and lipofuscin, increase hippocampus PSD-95,
The expression of PKC and BDNF.Pericarpium Citri tangerinae and blue berry/Fructus Mori, containing lot of anthocyanin class polyphenol substance, can remove oxygen freely
Base, reparation oxidative damage etc., have delaying senility, improve the effects such as memory；Including Pericarpium Citri tangerinae rich in antioxidant not
Only be conducive to the disease such as tumor and heart, the most useful for the reversibility of neuron and the ageing process of behavior.DHA, two
Dodecahexaene acid, is the important component part of brain, is also the necessary material of normal neuro-function, and the DHA in brain contains
Amount reduction can cause the decline of memory ability；Long-term taking can be effectively improved ischemic brain injury rich in the fish oil of DHA to be caused
Amnesia；DHA meal supplement can strengthen adult man memory and the respond of low DHA dietary habit.Semen Lini
Belong to traditional oil crop in China, containing abundant alpha-linolenic acid, be the known plants that current n-3 content of fatty acid is the highest
One of oils and fats, alleviates the cognitive dysfunction of aged rats by activating the CREB signal path of hippocampus, and it may be with
EPA, DHA belong to n-3 unsaturated fatty acid together and the precursor as both is relevant.
Compared with prior art, the invention has the beneficial effects as follows:
1, cognitive and memory are repaired and improve by the present invention each raw material from many aspects, more comprehensively cover all kinds of needs and improve
The crowd of memory, is particularly suited for the Chinese population that DHA lacks, has definite auxiliary improvement of memory effect.The present invention will
Threpsology combines with Advantages of TCM, based on theory of Chinese medical science, through experimentation for many years and raw material screening, selects happy benefit
The Radix Ginseng (or Radix Pseudostellariae/Radix Codonopsis/Radix Panacis Quinquefolii/Radix Polygalae) of intelligence tonifying QI to produce body fluid, its rich in Saponin have in modern medicine regulation god
Through cental system, effect of fatigue alleviating, can by regulate each memory related pathways and resisting fatigue repair the decline of memory with
Damage；And the Pericarpium Citri tangerinae of strong anti-oxidation fruit (or blue berry) is containing abundant anthocyan material, and blood brain barrier can be passed through
Can be done directly on brain, the amnesia caused for all kinds of anoxias, ischemia and free radical and damage are repaired and improve；
DHA be human brain must material, take part in the foundation of various functions in brain, and domestic absorption relatively lack；Last with Semen Lini oil
It is supplementary, effect of the function of each tissue in n-3 fatty acid improves brain can be given full play to.
2, preparation method of the present invention is simple, remains nutrition and the functional component of primary raw material, simultaneously can also be flexibly
It is applied to all kinds of dosage form.
3, the present invention is through experimentation for many years and raw material screening, uses modern extraction technique to extract traditional medicine,
Prepare be effectively improved memory plant derived food compositions, it is adaptable to different classes of memory declines crowd, and this combination is through dynamic
Thing experiment shows safe without toxic side effect, is suitable for being eaten for a long time, and water maze, diving tower, step-through test conclusion are the positive, tool
There is the health care of auxiliary improvement of memory, significant for promoting quality of residents'life and health level.
Specific embodiments
In order to be more fully understood that the present invention, it is further elucidated with present disclosure below in conjunction with embodiment and pharmacodynamic study result,
But the present invention is not limited solely to the following examples.
A kind of compositions said composition with auxiliary improving memory function is mainly prepared by following raw material: Radix Ginseng, Pericarpium Citri tangerinae,
DHA algal oil, Semen Lini oil；As preferably, by weight, Radix Ginseng 20～160 parts, Pericarpium Citri tangerinae 100～4000 parts, DHA
Algae oil 10～100 parts, Semen Lini oil 50～400 parts；Preferably, by weight, Radix Ginseng 40～160 parts, Pericarpium Citri tangerinae
1000～4000 parts, DHA algal oil 20～100 parts, Semen Lini oil 100～400 parts；Some case study on implementation in the present invention
In, by weight, Radix Ginseng 100 parts, Pericarpium Citri tangerinae 2400 parts, DHA algal oil 60 parts, Semen Lini oil 200 parts；In the present invention
Some case study on implementation in, by weight, Radix Ginseng 100 parts, Pericarpium Citri tangerinae 1000 parts, DHA algal oil 60 parts, Semen Lini oil
300 parts；In some case study on implementation of the present invention, by weight, Radix Ginseng 80 parts, Pericarpium Citri tangerinae 2400 parts, DHA algal oil 80
Part, Semen Lini oil 100 parts；In some case study on implementation of the present invention, by weight, Radix Ginseng 80 parts, Pericarpium Citri tangerinae 1000 parts,
DHA algal oil 80 parts, Semen Lini oil 200 parts.In the present invention, Radix Ginseng can be with a kind of in Radix Pseudostellariae/Radix Codonopsis/Radix Panacis Quinquefolii/Radix Polygalae
Or several substitute, Pericarpium Citri tangerinae can one or more substitute with blue berry/Fructus Mori, and DHA algal oil can substitute with fish oil.
Same DHA algal oil can select the algae powder of identical fat content to substitute, and Semen Lini oil can select identical fat content
Linseed meal substitute.Adjuvant is acceptable adjuvant in pharmaceutically acceptable adjuvant or bromatology.
As preferably, after described combination forming, can be made into powder, granule, hard capsule, soft capsule, ordinary tablet, dispersion
The dosage forms such as sheet, buccal tablet, chewable tablet, oral liquid, but the dosage form of medicine of the present invention is not limited to this.The present invention also carries
For a kind of product, this product is health food, and this product includes the compositions that adjuvant and the present invention provide.Those skilled in the art
Think feasible dosage form all within protection scope of the present invention, the present invention is in this no limit.
A part of specific embodiment is set forth below, and the present invention will be described, it is necessary to it is pointed out here that be specific examples below only
For the invention will be further described, do not represent limiting the scope of the invention.Other people make according to the present invention one
A little nonessential amendments and adjustment still fall within protection scope of the present invention.
Described in following embodiment, percent, ratio are without adding explanation, all in terms of mass percent, mass ratio.
Embodiment 1
A kind of compositions powder with auxiliary improving memory function, its component is that the mixture of following raw materials in part by weight is made:
Radix Ginseng 100 parts, Pericarpium Citri tangerinae 2400 parts, DHA algal oil 60 parts, Semen Lini oil 200 parts.Its preparation method includes walking as follows
Rapid:
1) each raw material is weighed in proportion；
2) Radix Ginseng with 90% ethanol solution, carry out with solid-liquid ratio 1:6, temperature 70-80 DEG C 2 times extract, 1.5h/ time, gained
Extracting solution is spray-dried after concentrating and obtains dry powder；
3) Pericarpium Citri tangerinae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 50%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 50% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) DHA algal oil and Semen Lini oil are respectively with arabic gum, maltodextrin 1:3 in mass ratio for wall material, core, wall material
1:1 in mass ratio carries out emulsifying embedding, and LS is dried and prepares microcapsule powder；
5) dry powder of gained Radix Ginseng ethanol extract, the dry powder of Pericarpium Citri tangerinae ethanol extract, the DHA algal oil of microencapsulation and Semen Lini oil are mixed
Closing, and add adjuvant maltodextrin mixing boiling granulating, adjuvant addition accounts for raw material gross weight 35-45%, must have auxiliary and change
The compositions powder of kind memory function.
Embodiment 2
A kind of composition soft with auxiliary improving memory function, its mixture system that component is following raw materials in part by weight
Become: Radix Ginseng 100 parts, Pericarpium Citri tangerinae 2400 parts, DHA algal oil 60 parts, Semen Lini oil 200 parts.Its preparation method includes as follows
Step:
1) each raw material is weighed in proportion；
2) Radix Ginseng carries out 2 times extract with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 70%, and 1.5h/ time, gained carries
Take to be spray-dried after liquid concentrates and obtain dry powder；
3) Pericarpium Citri tangerinae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 60%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 30% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) by the dry powder of gained Radix Ginseng ethanol extract, the dry powder blend of Pericarpium Citri tangerinae ethanol extract, DHA algal oil and Semen Lini oil are added
In, and adding natural Vitamin E, Cera Flava, phospholipid, adjuvant addition accounts for and always weighs about 5-10%, and mix homogeneously is pressed into
There is the composition soft of auxiliary improving memory function.
Embodiment 3
A kind of compositions hard capsule with auxiliary improving memory function, its mixture system that component is following raw materials in part by weight
Become: Radix Ginseng 100 parts, Pericarpium Citri tangerinae 1000 parts, DHA algal oil 60 parts, Oleum Perillae 300 parts.Its preparation method includes as follows
Step:
1) each raw material is weighed in proportion；
2) Radix Ginseng carries out 2 times extract with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 80%, and 1.5h/ time, gained carries
Take to be spray-dried after liquid concentrates and obtain dry powder；
3) Pericarpium Citri tangerinae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 70%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 70% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) DHA algal oil and Oleum Perillae are respectively with arabic gum, maltodextrin 1:3 in mass ratio for wall material, core, wall material
1:1 carries out emulsifying embedding in mass ratio, and LS is dried and prepares microcapsule powder；
5) dry powder of gained Radix Ginseng ethanol extract, the dry powder of Pericarpium Citri tangerinae ethanol extract, the DHA algal oil of microencapsulation and Semen Lini oil are mixed
Closing, and add supplementary product starch, magnesium stearate, silicon dioxide, adjuvant addition accounts for raw material and always weighs about 20-30%, mix homogeneously
Pelletize, load hard capsule, must have the compositions hard capsule of auxiliary improving memory function.
Embodiment 4
A kind of composition tablet with auxiliary improving memory function, its component is that the mixture of following raw materials in part by weight is made:
Radix Ginseng 80 parts, Pericarpium Citri tangerinae 2400 parts, split 240 parts of kettle algae, Semen Lini 200 parts.Its preparation method comprises the steps:
1) each raw material is weighed in proportion；
2) Radix Ginseng carries out 2 times extract with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 80%, and 1.5h/ time, gained carries
Take to be spray-dried after liquid concentrates and obtain dry powder；
3) Pericarpium Citri tangerinae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 40%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 60% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) rich in DHA split kettle algae and Semen Lini is separately dried pulverizing and is prepared as dry powder；
5) dry powder of gained Radix Ginseng ethanol extract, the dry powder of Pericarpium Citri tangerinae ethanol extract, algae powder and linseed meal are mixed, and add shallow lake
Powder, magnesium stearate, microcrystalline Cellulose, adjuvant addition accounts for raw material and always weighs about 35-45%, mix homogeneously dry granulation, pressure
Sheet, coating, must have the composition tablet of auxiliary improving memory function.
Embodiment 5
A kind of compositions powder with auxiliary improving memory function, its component is that the mixture of following raw materials in part by weight is made:
Radix Ginseng 80 parts, Pericarpium Citri tangerinae 1000 parts, DHA algal oil 80 parts, Semen Lini oil 200 parts.Its preparation method comprises the steps:
1) each raw material is weighed in proportion；
2) Radix Ginseng carries out 2 water extraction with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 80%, 1.5h/ time, gained
Extracting solution is spray-dried after concentrating and obtains dry powder；
3) Pericarpium Citri tangerinae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 50%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 50% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) DHA algal oil and Semen Lini oil are respectively with arabic gum, maltodextrin 1:3 in mass ratio for wall material, core, wall material
1:1 in mass ratio carries out emulsifying embedding, and LS is dried and prepares microcapsule powder；
5) dry powder of gained Radix Ginseng ethanol extract, the dry powder of Pericarpium Citri tangerinae ethanol extract, the DHA algal oil of microencapsulation and Semen Lini oil are mixed
Close, add the maltodextrin mixing boiling granulating accounting for raw material gross weight 25-35%, must have the combination of auxiliary improving memory function
Medicinal powder.
Embodiment 6
A kind of composition tablet with auxiliary improving memory function, its component is that the mixture of following raw materials in part by weight is made:
Radix Panacis Quinquefolii 80 parts, blue berry 2400 parts, DHA algal oil 80 parts, Oleum Perillae 100 parts.Its preparation method includes walking as follows
Rapid:
1) each raw material is weighed in proportion；
2) Radix Panacis Quinquefolii carries out 2 times extract with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 80%, 1.5h/ time, gained
Extracting solution is spray-dried after concentrating and obtains dry powder；
3) blue berry carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 60%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 30-70% ethanol solution eluting, collect eluent, it is dry that concentrated spray is dried acquisition
Powder；
4) DHA algal oil and Oleum Perillae are respectively with arabic gum, maltodextrin 1:3 in mass ratio for wall material, core, wall material
1:1 carries out emulsifying embedding in mass ratio, and LS is dried and prepares microcapsule powder；
5) by the dry powder of gained Radix Panacis Quinquefolii ethanol extract, the dry powder of blue berry ethanol extract, the DHA algal oil of microencapsulation and Oleum Perillae
Mixing, and add the starch of 35-45%, magnesium stearate, microcrystalline Cellulose, mix homogeneously dry granulation, tabletting, coating,
Must have the composition tablet of auxiliary improving memory function.
Embodiment 7
A kind of composition soft with auxiliary improving memory function, its mixture system that component is following raw materials in part by weight
Become: Radix Codonopsis 100 parts, blue berry 2400 parts, 60 parts of fish oil, Semen Lini oil 200 parts.Its preparation method comprises the steps:
1) each raw material is weighed in proportion；
2) Radix Codonopsis carries out 2 times extract with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 75%, and 1.5h/ time, gained carries
Take to be spray-dried after liquid concentrates and obtain dry powder；
3) blue berry carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 55%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 45% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) by the dry powder of gained Radix Codonopsis ethanol extract, the dry powder blend of blue berry ethanol extract, add in fish oil and Semen Lini oil, and add
Add the natural Vitamin E of 6-10%, Cera Flava, phospholipid, mix homogeneously, be pressed into have the combination of auxiliary improving memory function
Composition soft capsule.
Embodiment 8
A kind of compositions hard capsule with auxiliary improving memory function, its mixture system that component is following raw materials in part by weight
Become: Radix Polygalae 100 parts, Pericarpium Citri tangerinae 1000 parts, DHA algal oil 60 parts, Semen Lini oil 300 parts.Its preparation method includes as follows
Step:
1) each raw material is weighed in proportion；
2) Radix Polygalae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 85%, and 1.5h/ time, gained carries
Take to be spray-dried after liquid concentrates and obtain dry powder；
3) Pericarpium Citri tangerinae carries out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 45%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 35% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) DHA algal oil and Semen Lini oil are respectively with arabic gum, maltodextrin 1:3 in mass ratio for wall material, core, wall material
1:1 carries out emulsifying embedding in mass ratio, and LS is dried and prepares microcapsule powder；
5) dry powder of gained polygalytol extract, the dry powder of Pericarpium Citri tangerinae ethanol extract, the DHA algal oil of microencapsulation and Semen Lini oil are mixed
Closing, and add the starch of 20-30%, magnesium stearate, silicon dioxide, mix homogeneously is pelletized, and loads hard capsule, must have
The compositions hard capsule of auxiliary improving memory function.
Embodiment 9
A kind of compositions powder with auxiliary improving memory function, its component is that the mixture of following raw materials in part by weight is made:
Radix Ginseng 80 parts, Fructus Mori 1000 parts, DHA algal oil 80 parts, Semen Lini oil 200 parts.Its preparation method comprises the steps:
1) each raw material is weighed in proportion；
2) Radix Ginseng carries out 2 water extraction with ethanol solution, solid-liquid ratio 1:6, temperature 70-80 DEG C of 75%, 1.5h/ time, gained
Extracting solution is spray-dried after concentrating and obtains dry powder；
3) Fructus Mori carry out 2 times extract with ethanol solution, solid-liquid ratio 1:8, temperature 65-75 DEG C of 50%, and 1.5h/ time, gained carries
Taking and cross macroporous resin after liquid suitably concentrates, with 50% ethanol solution eluting, collect eluent, concentrated spray is dried acquisition dry powder；
4) DHA algal oil and Semen Lini oil are respectively with arabic gum, maltodextrin, soybean protein 1:2:2 in mass ratio as wall
Material, core, wall material 1:1 in mass ratio carry out emulsifying embedding, and LS is dried and prepares microcapsule powder；
5) dry powder of gained Radix Ginseng ethanol extract, the dry powder of Fructus Mori ethanol extract, the DHA algal oil of microencapsulation and Semen Lini oil are mixed
Close, add the maltodextrin mixing boiling granulating of 25-35%, must have the compositions powder of auxiliary improving memory function.
Below as a example by the compositions prepared by embodiment 2, to the compositions with auxiliary improving memory function of the present invention
Carry out animal toxicology test and improve the research of mouse memory.
The research of compositions animal toxicology test
1 material and method
1.1 samples and process: the compositions of embodiment 2 preparation is content, human body recommends daily intaking amount to be 0.045g/kg BW
(according to adult's 60kg body weight mean value computation).
1.2 animal varietiess:
SPF level Kunming mouse and Wistar rat: Animal Experimental Study center, Hubei Province provides, and production licence number is
SCXK (Hubei Province) 2015-0018.
Feeding environment: SPF level Animal Lab., temperature 20～26 DEG C, humidity 40～70%, use credit number is
SYXK (Hubei Province) 2012-0065.
1.3 chmice acute Oral toxicities, genetoxic, mouse sperm deformity, 30 days feeding trials
Method is referring specifically to Ministry of Public Health " health food inspection and assessment technique specification " (version in 2003)
Data base set up by 1.4 experimental data statistical experiment data Microsoft Excel softwares, and measurement data uses t inspection
Testing, enumeration data and ranked data use SPSS software to carry out non parametric tests, and add up respectively by Animal Sex.
2 results
2.1 chmice acute Oral toxicity result of the tests are shown in Table 1.
Within the observation period of 14 days, animal has no obvious poisoning symptom, and also without animal dead, MTD value is more than 19.34g/kg
BW, by acute toxicity grading criteria evaluation, the nontoxic level in the true border of this given the test agent.
Table 1 acute toxicity test in mice result (mean ± standard deviation)
2.2 genetic toxicity test
2.2.1 mouse marrow cell micro nuclear test the results are shown in Table 2.
Comparing with negative control group, positive controls male and female micronuclei in mice rate has significant difference (P < 0.01).
Comparing with negative control group, there are no significant (P > 0.05) for given the test agent each dosage group male and female micronuclei in mice rate difference, and all
In range of normal value, show that this given the test agent Micronucleus test result is for feminine gender.Given the test agent each dosage group immaturity
Erythrocyte accounts for the ratio [PCE/ (PCE+NCE) sum] of Erythrocytes and is no less than the 20% of negative control group.
Table 2 mouse marrow cell micro nuclear test result (mean ± standard deviation)
**: compare with negative control group, P < 0.01；PCE: polychromatic erythrocyte, NCE: mature erythrocyte.
2.2.2. mouse inbred strain the results are shown in Table 3.
Comparing with negative control group, positive controls Sperm Abnormalities of Mice has significant difference (P < 0.01).
Comparing with negative control group, there are no significant (P > 0.05) for given the test agent each dosage group Sperm malformation rate difference, and
In range of normal value, show that this given the test agent sperm malformation test result is for feminine gender.
Table 3 mouse inbred strain result (mean ± standard deviation)
▲Other deformities: include tail folding, double end, double tails etc.；**: compare with negative control group, P < 0.01.
2.3 30 days feeding trials
2.3.1 animal typically shows in process of the test animal without death, and hair is normal, behavior expression without exception.
2.3.2 on rat body weight, food-intake, the affecting given the test agent each dosage group rat body weight weekly, enter of food utilization
There are no significant with negative control group comparing difference (P > 0.05) for appetite, food utilization.
2.3.3 hematological examination result
With negative control group numeric ratio relatively, given the test agent each dosage group WBC, RBC, Hb and leukocyte differential count indicator difference are equal
Without significance (P > 0.05), and all in range of normal value.
2.3.4 pathologic diagnosis
Gross anatomy finding of naked eye: negative control group and each dosage group rat mental status are good, and each internal organs naked eyes are showed no substantially
Abnormal.
Negative control group: a small amount of inflammatory cell infiltration (2/20, female 0/10, male 2/10) in individual animal kidney；Liver
Dirty, spleen, gastrointestinal, ovary, the internal organs such as testis show no obvious abnormalities.
High dose group: a small amount of hepatic cell fattydegeneration (1/20, female 1/10, male 0/10) in individual animal liver；Individually
A small amount of inflammatory cell infiltration (2/20, female 0/10, male 2/10) in animal kidney；Spleen, gastrointestinal, ovary, testis etc.
Internal organs show no obvious abnormalities.
3. brief summary
(1) given the test agent SPF level Kunming mouse acute oral toxicity test to two kinds of sexes, single oral gavage integral dose
Reach 19.34g/kg BW (be equivalent to human body and recommend 429.8 times of daily intaking amount 0.045g/kg BW), within the observation period of 14 days
Animal has no obvious poisoning symptom and death, and this product MTD value is more than 19.34g/kg BW, according to acute toxicity grading evaluation mark
Quasi-regulation, the nontoxic level in the true border of this given the test agent；
(2) binomial mutagenicity test (mouse marrow cell micro nuclear test and sperm malformation test) result is feminine gender；
Within (3) 30 days, feeding trial result shows: by given the test agent by 1.125g/kg BW, 2.250g/kg BW, 4.500
G/kg BW dosage (being respectively equivalent to human body recommends day to take in 25 times of 0.045g/kg BW, 50 times, 100 times) is to SPF
Level Wistar rat gives 30 days continuously, and animal has no obvious poisoning symptom and death.Given the test agent each dosage group rat body
Weight, food-intake, food utilization, hematology, blood biochemical, organ weights, dirty/body ratio and histopathology etc. refer to
Mark compares with negative control group, and there are no significant for difference, does not finds that this given the test agent has obvious toxicity to make under this experimental condition
With.
Composition for improved mouse memory is studied
1 materials and methods
1.1 sample sources and process
Example 2 preparation compositions content be given the test agent, human body recommend daily intaking amount be 2.7g/ days (i.e.
0.045g/kg BW)。
Sample preparation: accurately weigh tested material 4.5g, 9.0g, 13.5g, is settled to 100mL with Oleum Arachidis hypogaeae semen respectively, for low,
Middle and high dosage group mouse stomach is used.
1.2 laboratory animals and environment
SPF level Kunming kind female mice, 18-22g, 300, provide at Animal Experimental Study center, Hubei Province.Laboratory animal is raw
Produce credit number: SCXK (Hubei Province) 2015-0018.
Animal feed: multifarious Jia Xing bio tech ltd, Wuhan provides, and credit number is SCXK (Hubei Province) 2011-
0011。
Feeding environment: SPF level Animal Lab., temperature 20～26 DEG C, humidity 40～70%, use credit number is
SYXK (Hubei Province) 2012-0065.
1.3 dosage packets
Recommend daily intaking amount 0.045g/kg BW to expand 10,20,30 times by human body and basic, normal, high three dosage groups are set, i.e.
0.45g/kg BW、0.90g/kg BW、1.35g/kg BW.Being divided into three experimental grouies, every experimental group includes negative control group
(distilled water), oiliness matched group (Oleum Arachidis hypogaeae semen), basic, normal, high dosage group, each dosage group laboratory animal number is 10, often
50 mices of experimental group, totally 150.Test one group and carry out water maze test；Test two groups and carry out step down test；Experiment three
Group carries out step-through test.The continuous gavage of mice 30 days, starts test next day.Each dosage group mice is all held by 10ml/kg BW
Amount per os gavage gives tested material, and negative control group gives to wait the distilled water of capacity, oil matched group to give to wait the Semen arachidis hypogaeae of capacity simultaneously
Oil.Additionally take 150 mices to carry out repeating experiment.
1.4 test method
Water maze test, step down test, keep away dark test method referring specifically to Ministry of Public Health " health food inspection with assessment technique advise
Model " (version in 2003)
1.5 statistical method
Carrying out variance analysis with SPSS software, follow procedure first carries out homogeneity test of variance, and variance is neat, calculates F value, F value
<F0.05, conclusion: no significant difference between each group mean: F value >=F0.05, P≤0.05, with multiple experimental grouies and a matched group
Between the comparative approach two-by-two of mean add up.
The data of abnormal or heterogeneity of variance are carried out suitable variable conversion, after meeting normal state or variance requires together, with conversion
After data add up；If being still not up to normal state or the neat purpose of variance after variable conversion, using rank test instead and adding up.
The enumeration data such as errors number, number of animals, available X2Inspection, the four directions total number of cases of table is less than 40, or total number of cases equals to or more than
40 but occur when theoretical value equals to or less than 1, exact method method should be used instead.
2 results
2.1. the impact that water maze test mouse memory is obtained by tested material
Compare with negative control group, oil control group mice reach home time, reach home before errors number and 2min in
The number of animals reached home all changes without obvious, there are no significant for difference (it is P > 0.05).Compare with negative control group and oil
Group compares, and the errors number before tested material high dose group is reached home significantly reduces, and difference all has significance (to be
P<0.05)；The number of animals reached home in time that each dosage group mice is reached home and 2min is all without substantially changing, and difference is equal
Without significance (be P > 0.05) (being shown in Table 4).
Table 4 tested material obtains impact to water maze test mouse memory
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
The impact that step down test mouse memory is obtained by 2.2 tested materials
Comparing with negative control group, oil control group mice training period and the incubation period of test period, errors number and wrong reaction rate are equal
Without substantially changing, there are no significant for difference (it is P > 0.05).
Comparing with negative control group and oil matched group, tested material each dosage group mice trains incubation period, training errors number and training
Mistake percentage rate changes without obvious, there are no significant for difference (it is P > 0.05) (being shown in Table 5).
After 24h during test, compare with negative control group and oil matched group, tested material each dosage group mice test incubation period, test
Errors number and test mistake percentage rate all change without obvious, there are no significant for difference (it is P > 0.05) (being shown in Table 6).
The impact on step down test training period mouse memory of table 5 tested material
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
The impact on step down test test period mouse memory of table 6 tested material
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
The impact that step down test mouse memory is disappeared by 2.3 tested materials
Comparing with negative control group, incubation period, errors number and the wrong reaction rate of test of disappearing remembered by oil control group mice diving tower
All without substantially changing, there are no significant for difference (it is P > 0.05).Comparing with negative control group and oil matched group, tested material is high
Dosage group mistake percentage rate substantially reduces, and difference all has significance (being P < 0.01).Each dosage group mice incubation period, mistake
Number of times all changes without obvious, there are no significant for difference (it is P > 0.05) (being shown in Table 7).
The impact that step down test mouse memory is disappeared by table 7 tested material
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
The impact on keeping away dark test mice Memory acquisition of 2.4 tested materials
Comparing with negative control group, incubation period, errors number and the wrong reaction rate of oil control group mice training are all without substantially changing
Become, there are no significant for difference (it is P > 0.05).Compare with negative control group and oil matched group, tested material each dosage group mice
Training errors number significantly reduces, and difference all has significance (being P < 0.01).Each dosage group mice training incubation period and training
Mistake percentage rate all changes without obvious, there are no significant for difference (it is P > 0.05) (being shown in Table 8).
After 24h during test, comparing with negative control group, the incubation period of oil control group mice test and errors number are all without substantially changing
Become, there are no significant for difference (it is P > 0.05).Compare with negative control group and oil matched group, tested material middle and high dosage group
Mice test is obviously prolonged incubation period, and difference all has significance (being P < 0.01).Compare with negative control group, low dose group
Mice test shorter latencies, difference has significance (P < 0.05), but compares with oil matched group, no significant difference
(P>0.05).Comparing with negative control group, each dosage group mice test errors number all significantly reduces, and difference all has significance
(being P < 0.01).Comparing with oil matched group, each dosage group mice test errors number all significantly reduces, and difference all has significantly
Property (P < 0.05, P < 0.01, P < 0.01).
After 24h during test, comparing with negative control group, the wrong reaction rate of oil control group mice test reduces, and difference has significantly
Property (P < 0.05).Comparing with negative control group and oil matched group, tested material each dosage group mice test wrong reaction rate is the most obvious
Reducing, difference all has significance (being P < 0.01).(being shown in Table 9).
Table 8 tested material is on keeping away the dark impact testing training period mouse memory
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
Table 9 tested material is on keeping away the dark impact testing test period mouse memory
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
2.5 tested materials remember, on keeping away dark test mice, the impact disappeared
Comparing with negative control group, oil control group mice is remembered the disappear incubation period of test, errors number and is all changed without obvious, poor
Different there are no significant (it is P > 0.05).Comparing with negative control group and oil matched group, tested material middle and high dosage group mice is dived
The volt phase is all obviously prolonged, and difference all has significance (being P < 0.01).Compare with oil matched group, high dose group mice incubation period
Extending, difference has significance (P<0.05), but compares with negative control group, no significant difference (P>0.05).Right with feminine gender
Comparing according to group and oil matched group, each dosage group mouse wrong times all significantly reduces, and difference all has significance (to be
P<0.01).Comparing with negative control group, oil matched group wrong reaction rate raises, and difference has significance (P < 0.05).With feminine gender
Matched group and oil matched group compare, and each dosage group mouse wrong response rate the most substantially reduces, and difference all has significance (to be
P < 0.01) (being shown in Table 10).
Table 10 tested material remembers, on keeping away dark test mice, the impact disappeared
* p < 0.05, * * p < 0.01 is compared with negative control group；#p < 0.05, ##p < 0.01 is compared with oil matched group
3 brief summaries
The application uses intact animal's model, recommends daily intaking amount 0.045g/kg BW to expand 10,20,30 times of works according to human body
For basic, normal, high three dosage groups, i.e. 0.45g/kgBW, 0.90g/kgBW, 1.35g/kgBW, use SPF level Kunming kind
Mice continuous per os gavage carried out the test about index after 30 days.Result of the test each dosage group compares with negative control group and oil
Group compares, and is judged as there is significant difference with P < 0.05, and result shows:
(1) water maze test: experimental result shows, Memory acquisition project, the errors number before high dose group is reached home is bright
Aobvious minimizing, experimental result is judged to the positive.
(2) step down test: test result and show, remembers the project that disappears, and high dose group mistake percentage rate substantially reduces.Experiment knot
Fruit is judged to the positive.
(3) keeping away dark test: experimental result shows, Memory acquisition project, each dosage group mice training errors number substantially subtracts
Few, the test of middle and high dosage group mice is obviously prolonged incubation period；Each dosage group mice test errors number all significantly reduces, test
Wrong reaction rate the most substantially reduces.Remembering the project that disappears, middle and high dosage group mice is all obviously prolonged incubation period；Each dosage group is little
Mus errors number all significantly reduces, and response rate the most substantially reduces.Experimental result is judged to the positive.The above is only the present invention
Preferred implementation,
It should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention, also may be used
To make some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (10)
1. a compositions with auxiliary improving memory function, it is characterised in that its component is mainly following raw materials in part by weight
Mixture or the extract prepared of this raw material: the Total saponin mass content raw material A 20 higher than 1%～160 parts,
Anthocyan polyphenol mass content higher than 0.1% raw material B 100～4000 parts, DHA mass content higher than 10% raw material C
10～100 parts, the alpha-linolenic acid mass content raw material D 50～400 higher than 30%.
2. a compositions with auxiliary improving memory function, it is characterised in that its component be following raw materials in part by weight
Extract prepared by mixture or this raw material: Total saponin mass content higher than 1% raw material A 40～160 parts, flower
The blue or green element class polyphenol mass content raw material B 1000 higher than 0.1%～4000 parts, the DHA mass content raw material C higher than 10%
20～100 parts, alpha-linolenic acid mass content higher than 30% raw material D 100～400 parts.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
The Total saponin mass content raw material A higher than 1% in Radix Ginseng, Radix Pseudostellariae, Radix Codonopsis, Radix Panacis Quinquefolii, the Radix Polygalae any one or several
Plant mixture in any proportion.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
In Pericarpium Citri tangerinae, blue berry, Fructus Mori, any one or a few presses arbitrarily the anthocyan polyphenol mass content raw material B higher than 0.1%
The mixture of ratio.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
The DHA mass content raw material C higher than 10% is any one or a few mixture in any proportion in algae oil, fish oil.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
The alpha-linolenic acid mass content raw material D higher than 30% in Semen Lini oil, the Oleum Perillae any one or a few by arbitrarily than
The mixture of example.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
Raw material A or raw material B are prepared as dry powder and use；The acquisition pattern of dry powder includes that following three kinds: one is, raw material passes through
It is dried, pulverizes the dry powder obtained；Two are, raw material after the extraction of solvent, the dry powder that concentrate drying is obtained；Three are, former
Material, after solvent extraction, concentrates and purifies the refined dry powder being dried and being obtained.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
Oil and fat preparation in raw material C or raw material D is microcapsule powder, will carry out embedding process by the oils and fats in raw material C or raw material D
Obtain microcapsule powder.
A kind of compositions with auxiliary improving memory function the most according to claim 1 and 2, it is characterised in that described
The compositions with auxiliary improving memory function is made powder, granule, hard capsule, soft capsule, ordinary tablet, dispersible tablet, is contained
The oral thing of sheet, chewable tablet or oral liquid.
10. comprise the health food of compositions described in claim 1 or 2, it is characterised in that described health food also includes auxiliary
Material, described in have the compositions of auxiliary improving memory function acceptable auxiliary in acceptable adjuvant or bromatology with in conventional pharmaceutical
Dosage form made by material is powder, granule, hard capsule, soft capsule, ordinary tablet, dispersible tablet, buccal tablet, chewable tablet or liquid oral
The oral thing of preparation.
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Application publication date: 20160928 |