CN102225149B - Traditional Chinese medicine compound for treating diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine compound for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine compound for treating diabetes and a preparation method thereof, wherein the medicine compound comprises the following 12 components: astragalus mongholicus, Chinese yam, the fruit of Chinese magnoliavine, rhizoma alismatis, radix scrophulariae, the root of kudzu vine, the root of red-rooted salvia, mongolian snakegourd root, raw rehmannia, dwarf lilyturf tuber, ginseng and coptis chinensis. The preparation method provided by the invention comprises the following steps: grinding the ginseng and the coptis chinensis in the twelve components into fine powder; adding water to the residual 10 components to be decocted twice, wherein 1-3 hours in the first time and 1-2.5 hours in the second time; blending the decoction liquid; concentrating until the relative density is 1.20-1.35 (at 50 DEG C); vacuum-drying; grinding; blending with the fine powder of the ginseng and the coptis chinensis; and preparing various conventional preparations in the field. The hypoglycemic effect of the traditional Chinese medicine compound provided by the invention is obvious. The invention also provides the preparation method of the medicine compound and the preparations thereof which are applied in clinic.
Description
The present invention is for dividing an application, and the original bill application number is 200710119637.2, and the original bill applying date is on July 27th, 2007, and the original bill name is called: a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof.
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof.
Background technology
China's diabetics surpasses 4,000 ten thousand, Beijing area more than 40 ten thousand.Diabetes have become the third-largest disease after cardiovascular and cerebrovascular disease, tumor, occupy the 5th of world's major causes of death.Diabetes have become stealthy killer and the demon of current serious harm humans health.
Existing Therapeutic Method generally adopts the orally-taken blood sugar reducing medicine to reach hypoglycemic purpose.The Western medicine of common treatment diabetes has sulphanylureas (such as glyburide) and biguanides (such as insoral) etc., although hypoglycemic effect is better in the recent period for this class medicine, the treatment diabetes is had certain effect, and long-term taking has certain side effect to human body.Belong to chemosynthesis medicine such as insoral, its blood sugar reducing function mainly is by suppressing intestinal to the absorption of glucose, reduce the release of glyconeogenesis and glucagon or suppress insulin antibody be used for realizing.Its side effect is mainly manifested in all has certain detrimental effect to hemogram, liver function, kidney merit, can cause patient's diabetic cardiovascular and cerebrovascular complication, hypoglycemic reaction occurs easily, and gastrointestinal is had zest, produces anorexia, feels sick, vomiting even diarrhoea etc.Therefore select efficient and can be for a long time and use without any side effectsly in a large number, curative effect be reliable, and the hypoglycemic medicine of taking convenience is practicable, thereby brings into play the advantage of TCM treatment of diabetes.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of replenishing QI to invigorate the spleen, clearing away heat and promoting production of body fluid, blood circulation promoting and blood stasis dispelling is used for deficiency of both QI and YIN, and the auxiliary treatment of Sheng type diabetes can be improved its thirsty polydipsia in the interior-heat, and fatigue and weakness is vexed, the symptoms such as constipation.
Another object of the present invention provides a kind of preparation method of this Chinese medicine composition.
Chinese medicine composition provided by the invention is prepared from by the raw material of following weight proportioning:
Radix Astragali 110-420 part Rhizoma Dioscoreae 80-280 part Fructus Schisandrae Chinensis 40-140 part Rhizoma Alismatis 40-140 part
Radix Scrophulariae 40-140 part Radix Puerariae 40-140 part Radix Salviae Miltiorrhizae 60-210 part Radix Trichosanthis 80-280 part
Radix Rehmanniae 80-280 part 40-140 Radix Ophiopogonis part Radix Ginseng 30-100 part Rhizoma Coptidis 30-100 part
Chinese medicine composition of the present invention preferably is prepared from by the raw material of following weight proportioning:
Radix Astragali 150-300 part Rhizoma Dioscoreae 100-200 part Fructus Schisandrae Chinensis 50-100 part Rhizoma Alismatis 50-100 part
Radix Scrophulariae 50-100 part Radix Puerariae 50-100 part Radix Salviae Miltiorrhizae 70-150 part Radix Trichosanthis 100-200 part
Radix Rehmanniae 100-200 part 50-100 Radix Ophiopogonis part Radix Ginseng 40-80 part Rhizoma Coptidis 40-80 part
Chinese medicine composition of the present invention more preferably is prepared from by the raw material of following weight proportioning:
70 parts of 70 portions of Rhizoma Alismatis of 140 parts of Fructus Schisandrae Chinensis of 210 portions of Rhizoma Dioscoreaes of the Radix Astragali
140 parts of 105 parts of Radix Trichosanthis of 70 parts of Radix Salviae Miltiorrhizaes of 70 parts of Radix Puerariaes of Radix Scrophulariae
50 parts of 50 portions of Rhizoma Coptidis of the Radix Rehmanniae 70 parts of Radix Ginsengs, 140 parts of Radix Ophiopogonis
Chinese medicine composition of the present invention can be prepared into various preparations by the ordinary skill in the art.
The present invention also provides a kind of preparation method of this Chinese medicine composition, and the method comprises the steps:
More than 12 the flavor, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, and all the other ten flavors decoct with water 2 times, 1～3 hour for the first time, 1～2.5 hour for the second time, collecting decoction is concentrated into relative density 1.20～1.35 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, then make the various conventional formulations in this area, as: capsule, tablet, granule, pill etc.
The preferred preparation method of Chinese medicinal composition capsules agent of the present invention comprises the steps:
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, relative density is 1.30 when being concentrated into 50 ℃, vacuum drying is pulverized, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, make 850, and get final product.
Chinese medicine composition of the present invention has been brought into play the multiple location of Chinese medicine, the effect of many target spots, according to main cause and the rule that diabetes occur, develop, replenishing QI to invigorate the spleen, clearing away heat and promoting production of body fluid; Flavour of a drug are few, but effect is complete, and clinical confirmation not only can improve symptom significantly, but also can suitably regulate blood glucose, promote the smooth rehabilitation of patient.The diabetes of the traditional Chinese medical science is to become thin or turbid urine, the pleasantly sweet disease as characteristics of urine take polydipsia, polyphagia, polyuria, health, and the diabetes of this and modern medicine are basic identical.According to theory of Chinese medical science, the assertive evidence pathogenic characteristic should be that the deficiency of YIN is this, and is scorching for marking.If course of disease delay is with the passing of time, then deficiency of YIN affecting YANG, cause impairment of both QI and YIN.For the characteristics of containing in primary disease deficiency of both QI and YIN, the interior-heat, the choice of drug Radix Astragali of the present invention is that monarch drug tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, diuresis poison holding, the key medicine of quenching one's thirst for treating interior-heat; Selecting Rhizoma Dioscoreae, Radix Trichosanthis, Radix Rehmanniae is ministerial drug, and monarch is nourshing Yin and drynsessmoistening prescription to help, the effect of supplementing QI for promoting the production of body fluid; Rhizoma Alismatis, Radix Scrophulariae, Rhizoma Coptidis clearing away heat-damp and promoting diuresis; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling; Choose ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis principal drug assistance the kidney invigorating and essence nourishing, YIN nourishing and the production of body fluid promoting.Full side plays replenishing QI to invigorate the spleen, replenishing YIN and removing heat, promoting the production of body fluid to quench thirst, blood circulation promoting and blood stasis dispelling altogether, so conform to the medicine card.
Beneficial effect
One, pharmacodynamics test research
1 material
1.1 110 of animal wistar rats, 40 of senile rats.Male and female are regardless of.
1.2 medicine pharmaceutical composition of the present invention is the capsule according to embodiment 1 preparation, test solution 6.0g (crude drug amount)/ml, and it is for subsequent use to put 4 ℃ of refrigerators.Be diluted to desired concn before the experiment, for gavage, the administration capacity is 5.0ml/kg.
The positive control medicine, commercially available JIANGTANGNING JIAONANG (0.4g/ grain) changes into suspension with normal saline before the experiment, and the administration capacity is the same;
Alloxan (AXN) is produced by U.S. sigma company;
Streptozocin (streptozotocim SIZ) is U.S. sigma company product;
2 observation index
2.1 blood glucose is measured with the ortho-aminotoluene method through the blood sampling of animal ventral aorta.
2.2 the identical medicine box description of pressing with determination method of blood sugar of serum insulin blood specimen collection is measured.
2.3 the serum levels of triglyceride blood specimen collection is the same.
3 methods and result
3.1 to 60 of the protective effect rats of artificial diabetes (IDDM) rat, minutes 6 groups, 10 every group, male and female half and half.Except the blank group, other groups cause the beta Cell of islet infringement with 150mg/kg once abdominal cavity injection alloxan, make blood sugar increasing surpass 8.96mmol/L, are diabetes model, for experiment.Gavage respectively medicine of the present invention (3.0g/kg, 24.0g/kg, 1.0g/kg), positive control medicine 3.0g/kg by grouping, Normal group and model group lumbar injection equivalent normal saline (NS), 1 time/d, continuous 20d.Test the 1st, 7,14,20 and respectively weigh 1 time, 24h processes animal after the last administration, by abdominal aortic blood, measures for blood glucose, serum insulin.The results are shown in Table 1.
Table 1 pharmaceutical composition of the present invention is to the observation of curative effect of experimental IDDM rat (x ± s)
Compare * P＜0.05, * * P＜0.01 with the IDDM group; Compare △ P＜0.05 with positive controls
As can be seen from the above table; medicine of the present invention and positive control medicine all have remarkable protective effect to experimental diabetic rats; medicine of the present invention and positive control medicine relatively to the secretory volume that increases insulin, there were significant differences to increase rat body weight, better to reducing the rat blood sugar effect.
3.2 the effect animal grouping to non-insulin-dependent experiment diabetes (NIDDM) rat is the same, is dissolved in the 0.1M citric acid with streptozocin, and lumbar injection 35mg/kg, 5d is to cause the NIDDM rat model continuously.6d begins, and every day is gavage NS pharmaceutical composition of the present invention (3.0g/kg, 2.0g/kg, 1.0g/kg) and positive control medicine 3.0g/kg respectively, and the administration capacity is the same, and successive administration 5d processes animal in 10d again, by abdominal aortic blood for mensuration.The results are shown in Table 2.
Table 2 pharmaceutical composition of the present invention is to the observation of curative effect of tentative NIDDM rat
Compare * P＜0.05, * * P＜0.01 with the IDDM group; Compare △ P＜0.05 with positive controls
As can be seen from the above table, medicine of the present invention and positive control medicine all have remarkable effect to the body weight increase of non-insulin-dependent experiment diabetes rat, and the big-and-middle dosage group of medicine of the present invention has remarkable effect to blood sugar lowering, serum triglycerides; Medicine of the present invention and positive control medicine relatively in the body weight that increases non-insulin-dependent experiment diabetes rat, to reduce aspect the serum triglycerides content effect more remarkable, better to reducing the blood glucose in diabetic rats effect.
3.3 senile rat blood glucose, blood fat and carbohydrate tolerance affected 60 of rats, every group 10, divide 6 groups: Elderly people group, pharmaceutical composition of the present invention (3.0g/kg, 2.0g/kg, 1.0g/kg) group, positive control medicine group (3.0g/kg) group, every day, gavage was 2 times.Other gets 10 of young rats and is the normal young group, and the dosage method is the same, and the raising condition is identical.7d gets blood by aorta in 8d morning on an empty stomach under pentobarbital sodium anesthesia continuously, surveys fasting blood sugar.And then gavage 50% glucose (5.0ml/kg) 1h post processing animal gets blood, is used as blood glucose, triglyceride, T-CHOL and measures.The results are shown in Table 3.
Table 3 medicine of the present invention is on the impact (x ± s, mmol/L) of geriatric animals blood glucose, blood fat and carbohydrate tolerance
Compare * P＜0.05, * * P＜0.01 with the IDDM group; Compare △ P＜0.05 with positive controls
As can be seen from the above table, medicine of the present invention and positive control medicine all do not affect senile rat fasting glucose concentration, to strengthening carbohydrate tolerance remarkable effect are arranged, and medicine of the present invention has remarkable effect to reducing the senile rat serum total cholesterol; Medicine of the present invention and positive control medicine relatively have significance to improve to raising senile rat carbohydrate tolerance, reduction serum total cholesterol content.
Can find out that from above result of the test pharmaceutical composition of the present invention has significant protective effect to tentative diabetes rat, can blood sugar lowering, increase the secretion of insulin, the body weight of animal is increased; Not only can blood sugar lowering to non-insulin-dependent test diabetes rat, the triglyceride of rising is reduced, and the body weight of animal is increased; To senile rat, do not affect its fasting blood glucose level, but can improve carbohydrate tolerance, reduce serum total cholesterol.
Further specify technical scheme of the present invention below by specific embodiment, but be not limited to the present invention.
Specific embodiment
Embodiment 1
Radix Astragali 210g Rhizoma Dioscoreae 140g Fructus Schisandrae Chinensis 70g Rhizoma Alismatis 70g
Radix Scrophulariae 70g Radix Puerariae 70g Radix Salviae Miltiorrhizae 105g Radix Trichosanthis 140g
Radix Rehmanniae 140g 70g Radix Ophiopogonis Radix Ginseng 50g Rhizoma Coptidis 50g
More than 12 the flavor, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, and all the other ten flavors decoct with water 2 times, 1～3 hour for the first time, 1～2.5 hour for the second time, collecting decoction is concentrated into relative density 1.20～1.35 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, then make the various conventional formulations in this area, as: capsule, tablet, granule, pill.
Embodiment 2
Radix Astragali 210g Rhizoma Dioscoreae 140g Fructus Schisandrae Chinensis 70g Rhizoma Alismatis 70g
Radix Scrophulariae 70g Radix Puerariae 70g Radix Salviae Miltiorrhizae 105g Radix Trichosanthis 140g
Radix Rehmanniae 140g 70g Radix Ophiopogonis Radix Ginseng 50g Rhizoma Coptidis 50g
More than 12 the flavor, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, and all the other ten flavors decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction is concentrated into relative density 1.30 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, then make various preparations according to the conventional preparation method of Chinese medicine, such as capsule, tablet, granule, pill etc.
Embodiment 3
The Radix Astragali 210g Rhizoma Dioscoreae 140g 70g Rhizoma Alismatis 70g that distinguishes the flavor of
Radix Scrophulariae 70g Radix Puerariae 70g Radix Salviae Miltiorrhizae 105g Radix Trichosanthis 140g
Radix Rehmanniae 140g 70g Radix Ophiopogonis Radix Ginseng 50g Rhizoma Coptidis 50g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction is concentrated into relative density 1.30 (50 ℃), and vacuum drying is pulverized, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, make 850, and get final product.
Embodiment 4
Radix Astragali 110g Rhizoma Dioscoreae 80g Fructus Schisandrae Chinensis 40g Rhizoma Alismatis 40g
Radix Scrophulariae 40g Radix Puerariae 40g Radix Salviae Miltiorrhizae 60g Radix Trichosanthis 80g
Radix Rehmanniae 80g 40g Radix Ophiopogonis Radix Ginseng 30g Rhizoma Coptidis 30g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 hours for the first time 2 times, 1.5 hours for the second time, collecting decoction was concentrated into relative density 1.30 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, and get final product.
Embodiment 5
Radix Astragali 150g Rhizoma Dioscoreae 100g Fructus Schisandrae Chinensis 50g Rhizoma Alismatis 50g
Radix Scrophulariae 50g Radix Puerariae 50g Radix Salviae Miltiorrhizae 70g Radix Trichosanthis 100g
Radix Rehmanniae 100g 50g Radix Ophiopogonis Radix Ginseng 40g Rhizoma Coptidis 40g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 hours for the first time 2 times, 1.5 hours for the second time, collecting decoction was concentrated into relative density 1.30 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, and get final product.
Embodiment 6
Radix Astragali 300g Rhizoma Dioscoreae 200g Fructus Schisandrae Chinensis 100g Rhizoma Alismatis 100g
Radix Scrophulariae 100g Radix Puerariae 100g Radix Salviae Miltiorrhizae 150g Radix Trichosanthis 200g
Radix Rehmanniae 200g 100g Radix Ophiopogonis Radix Ginseng 80g Rhizoma Coptidis 80g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 hours for the first time 2 times, 1.5 hours for the second time, collecting decoction was concentrated into relative density 1.30 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, and get final product.
Embodiment 7
Radix Astragali 420g Rhizoma Dioscoreae 280g Fructus Schisandrae Chinensis 140g Rhizoma Alismatis 140g
Radix Scrophulariae 140g Radix Puerariae 140g Radix Salviae Miltiorrhizae 210g Radix Trichosanthis 280g
Radix Rehmanniae 280g 140g Radix Ophiopogonis Radix Ginseng 100g Rhizoma Coptidis 100g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 hours for the first time 2 times, 1.5 hours for the second time, collecting decoction was concentrated into relative density 1.30 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, and get final product.
Embodiment 8
Radix Astragali 340g Rhizoma Dioscoreae 210g Fructus Schisandrae Chinensis 120g Rhizoma Alismatis 80g
Radix Scrophulariae 120g Radix Puerariae 90g Radix Salviae Miltiorrhizae 180g Radix Trichosanthis 180g
Radix Rehmanniae 260g 80g Radix Ophiopogonis Radix Ginseng 70g Rhizoma Coptidis 60g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 hours for the first time 2 times, 1.5 hours for the second time, collecting decoction was concentrated into relative density 1.30 (50 ℃), vacuum drying, pulverize, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, and get final product.
Embodiment 9
Radix Astragali 247g Rhizoma Dioscoreae 165g Fructus Schisandrae Chinensis 82g Rhizoma Alismatis 82g
Radix Scrophulariae 82g Radix Puerariae 82g Radix Salviae Miltiorrhizae 124g Radix Trichosanthis 165g
Radix Rehmanniae 165g 82g Radix Ophiopogonis Radix Ginseng 59g Rhizoma Coptidis 59g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction is concentrated into relative density 1.30 (50 ℃), and vacuum drying is pulverized, mix with Radix Ginseng, Rhizoma Coptidis fine powder, incapsulate, make 1000, and get final product.
Embodiment 10
Radix Astragali 210g Rhizoma Dioscoreae 140g Fructus Schisandrae Chinensis 70g Rhizoma Alismatis 70g
Radix Scrophulariae 70g Radix Puerariae 70g Radix Salviae Miltiorrhizae 105g Radix Trichosanthis 140g
Radix Rehmanniae 140g 70g Radix Ophiopogonis Radix Ginseng 50g Rhizoma Coptidis 50g
More than 12 flavors, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction is concentrated into relative density 1.30 (50 ℃), and vacuum drying is pulverized, and mixes with Radix Ginseng, Rhizoma Coptidis fine powder, granulate, drying, granulate, tabletting, and get final product.
Embodiment 11
The Radix Astragali 210g Rhizoma Dioscoreae 140g 70g Rhizoma Alismatis 70g that distinguishes the flavor of
Radix Scrophulariae 70g Radix Puerariae 70g Radix Salviae Miltiorrhizae 105g Radix Trichosanthis 140g
Radix Rehmanniae 140g 70g Radix Ophiopogonis Radix Ginseng 50g Rhizoma Coptidis 50g
More than 12 the flavor, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten the flavor decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, be concentrated into relative density 1.30 (50 ℃), vacuum drying is pulverized, mix with Radix Ginseng, Rhizoma Coptidis fine powder, with the ratio mix homogeneously of Macrogol 4000 according to 3: 7,80 ℃ of insulations, through the water dropper of a certain size caliber, constant speed splashes in the liquid paraffin, and the pill that will solidify formation takes out, the flush away liquid coolant, drying, and get final product.
Embodiment 12
Radix Astragali 210g Rhizoma Dioscoreae 140g Fructus Schisandrae Chinensis 70g Rhizoma Alismatis 70g
Radix Scrophulariae 70g Radix Puerariae 70g Radix Salviae Miltiorrhizae 105g Radix Trichosanthis 140g
Radix Rehmanniae 140g 70g Radix Ophiopogonis Radix Ginseng 50g Rhizoma Coptidis 50g
More than 12 the flavor, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten the flavor decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, be concentrated into relative density 1.30 (50 ℃), vacuum drying is pulverized, mix with Radix Ginseng, Rhizoma Coptidis fine powder, vegetable oil is mixed according to 2: 1 ratio with fine drug powder, add again an amount of suspending agent, mix homogeneously, be pressed into soft capsule, and get final product.Soft capsule shell is comprised of in 1.0: 0.35: 1.0 ratio gelatin, G ﹠ W.
Claims (7)
1. Chinese medicine composition for the treatment of diabetes is characterized in that said composition prepares by the following method:
Choose the crude drug of following weight proportioning:
Radix Astragali 110-420 part Rhizoma Dioscoreae 80-280 part Fructus Schisandrae Chinensis 40-140 part Rhizoma Alismatis 40-140 part Radix Scrophulariae 40-140 part Radix Puerariae 40-140 part Radix Salviae Miltiorrhizae 60-210 part Radix Trichosanthis 80-280 part Radix Rehmanniae 80-280 part 40-140 Radix Ophiopogonis part Radix Ginseng 30-100 part Rhizoma Coptidis 30-100 part; More than 12 the flavor, Radix Ginseng, Rhizoma Coptidis powder are broken into fine powder, all the other ten flavors decoct with water 2 times, and 1～3 hour for the first time, 1～2.5 hour for the second time, collecting decoction, relative density is 1.20～1.35 when being concentrated into 50 ℃, and vacuum drying is pulverized, mix with Radix Ginseng, Rhizoma Coptidis fine powder, then make the various conventional formulations in this area.
2. Chinese medicine composition as claimed in claim 1 is characterized in that the weight proportion of crude drug is:
Radix Astragali 150-300 part Rhizoma Dioscoreae 100-200 part Fructus Schisandrae Chinensis 50-100 part Rhizoma Alismatis 50-100 part Radix Scrophulariae 50-100 part Radix Puerariae 50-100 part Radix Salviae Miltiorrhizae 70-150 part Radix Trichosanthis 100-200 part Radix Rehmanniae 100-200 part 50-100 Radix Ophiopogonis part Radix Ginseng 40-80 part Rhizoma Coptidis 40-80 part.
3. Chinese medicine composition as claimed in claim 2 is characterized in that the weight proportion of crude drug is:
50 parts of 50 portions of Rhizoma Coptidis of 140 parts of Radix Rehmanniae of 105 parts of Radix Trichosanthis of 70 parts of Radix Salviae Miltiorrhizaes of 70 parts of Radix Puerariaes of 70 portions of Radix Scrophulariaes of 70 portions of Rhizoma Alismatis of 140 parts of Fructus Schisandrae Chinensis of 210 portions of Rhizoma Dioscoreaes of the Radix Astragali, 70 parts of Radix Ginsengs, 140 parts of Radix Ophiopogonis.
4. such as any described Chinese medicine composition of claim 1-3, it is characterized in that: it is capsule, tablet, granule, pill.
5. such as the application of the described Chinese medicine composition of claim 1-3 any one in preparation treatment diabetes medicament.
6. a Chinese medicine composition is in the application for preparing treatment noninsulindependent diabetes medicine, and described compositions is prepared by following crude drug:
Radix Astragali 110-420 part Rhizoma Dioscoreae 80-280 part Fructus Schisandrae Chinensis 40-140 part Rhizoma Alismatis 40-140 part Radix Scrophulariae 40-140 part Radix Puerariae 40-140 part Radix Salviae Miltiorrhizae 60-210 part Radix Trichosanthis 80-280 part Radix Rehmanniae 80-280 part 40-140 Radix Ophiopogonis part Radix Ginseng 30-100 part Rhizoma Coptidis 30-100 part.
7. application as claimed in claim 6, described compositions is prepared by following crude drug:
Radix Astragali 150-300 part Rhizoma Dioscoreae 100-200 part Fructus Schisandrae Chinensis 50-100 part Rhizoma Alismatis 50-100 part Radix Scrophulariae 50-100 part Radix Puerariae 50-100 part Radix Salviae Miltiorrhizae 70-150 part Radix Trichosanthis 100-200 part Radix Rehmanniae 100-200 part 50-100 Radix Ophiopogonis part Radix Ginseng 40-80 part Rhizoma Coptidis 40-80 part.
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| CN102430001B (en) * | 2011-12-07 | 2013-06-12 | 河北联合大学 | Compound rose-hip flavone preparation for preventing diabetes mellitus and preparation method thereof |
| CN103162515B (en) * | 2011-12-13 | 2017-06-23 | 天津天士力现代中药资源有限公司 | A kind of drying means of ophiopogon japonicus extract |
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