CN105960237B - Ccr6化合物 - Google Patents

Ccr6化合物 Download PDF

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Publication number
CN105960237B
CN105960237B CN201480065637.7A CN201480065637A CN105960237B CN 105960237 B CN105960237 B CN 105960237B CN 201480065637 A CN201480065637 A CN 201480065637A CN 105960237 B CN105960237 B CN 105960237B
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group
ring
compounds
acid
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CN105960237A (zh
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D·戴拉菲
D·R·德拉戈利
J·凯利西亚克
C·W·朗格
M·R·乐乐缇
李延东
敏瑜·R·雷
V·R·马利
V·马拉松
J·P·鲍威尔斯
H·塔纳卡
J·覃
M·J·沃尔特斯
杨菊
张朋烈
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Chemocentryx Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Urology & Nephrology (AREA)
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  • Reproductive Health (AREA)
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CN201480065637.7A 2013-12-02 2014-12-02 Ccr6化合物 Active CN105960237B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361910838P 2013-12-02 2013-12-02
US61/910,838 2013-12-02
PCT/US2014/068152 WO2015084842A1 (en) 2013-12-02 2014-12-02 Ccr6 compounds

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CN105960237A CN105960237A (zh) 2016-09-21
CN105960237B true CN105960237B (zh) 2020-03-31

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US (4) US9340509B2 (enExample)
EP (1) EP3076968B1 (enExample)
JP (1) JP6563947B2 (enExample)
KR (1) KR102331833B1 (enExample)
CN (1) CN105960237B (enExample)
AU (1) AU2014360743C1 (enExample)
CA (1) CA2930148C (enExample)
EA (1) EA029826B1 (enExample)
ES (1) ES2735360T3 (enExample)
IL (1) IL245704B (enExample)
MX (1) MX2016007128A (enExample)
WO (1) WO2015084842A1 (enExample)
ZA (1) ZA201603167B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014360743C1 (en) 2013-12-02 2021-01-28 Chemocentryx, Inc. CCR6 compounds
RU2020106383A (ru) 2017-08-14 2021-09-16 Аллерган, Инк. 3,4-двузамещенные 3-циклобутен-1,2-дионы и их применение
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
KR102880470B1 (ko) 2018-10-23 2025-11-03 다이이찌 산쿄 가부시키가이샤 바이아릴 유도체
CN117018202A (zh) * 2019-07-08 2023-11-10 上海交通大学医学院附属瑞金医院 趋化因子受体ccr6抑制剂在预防银屑病复发中的新应用
CA3145303A1 (en) 2019-07-10 2021-01-14 Chemocentryx, Inc. Indanes as pd-l1 inhibitors
EP4045036A4 (en) 2019-10-16 2023-11-15 ChemoCentryx, Inc. Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases
EP4045037A4 (en) 2019-10-16 2023-11-15 ChemoCentryx, Inc. HETEROARYL-BIPHENYL AMINE FOR THE TREATMENT OF PD-L1 DISEASE
IL297675A (en) 2020-04-30 2022-12-01 Idorsia Pharmaceuticals Ltd History of aztidine-3-ylmethanol as ccr6 receptor modulators
KR20240049280A (ko) 2021-08-18 2024-04-16 케모센트릭스, 인크. Ccr6 억제제로서의 아릴 설포닐(하이드록시) 피페리딘
MX2024002173A (es) * 2021-08-18 2024-03-26 Chemocentryx Inc Compuestos de arilsulfonilo como inhibidores de ccr6.
WO2023057548A1 (en) 2021-10-07 2023-04-13 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators
JP2024539987A (ja) 2021-10-26 2024-10-31 イドルシア・ファーマシューティカルズ・リミテッド Ｃｃｒ６受容体調節剤
CA3236396A1 (en) 2021-10-28 2023-05-04 Oliver Allemann Ccr6 receptor modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006076644A2 (en) * 2005-01-14 2006-07-20 Chemocentryx, Inc. Heteroaryl sulfonamides and ccr2
CN101820881A (zh) * 2007-07-12 2010-09-01 坎莫森特里克斯公司 作为ccr2调节剂用于治疗炎症的稠合杂芳基吡啶基和苯基苯磺酰胺
WO2011119518A1 (en) * 2010-03-25 2011-09-29 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944553A (en) 1974-02-13 1976-03-16 Trw Inc. Bis quinoline peri acids
US4021409A (en) 1975-06-19 1977-05-03 The United States Of America As Represented By The Secretary Of The Air Force Thermally stable benzimidazonaphthyridine compositions
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
LU86084A1 (fr) 1985-09-20 1987-04-02 Faco Sa Apparei de massage electrique
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
WO1990013332A1 (en) 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Stent with sustained drug delivery
WO1991012779A1 (en) 1990-02-28 1991-09-05 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US5833651A (en) 1996-11-08 1998-11-10 Medtronic, Inc. Therapeutic intraluminal stents
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
WO2005113513A2 (en) * 2004-05-12 2005-12-01 Chemocentryx Aryl sulfonamides
EA015710B1 (ru) 2006-07-14 2011-10-31 Хемоцентрикс, Инк. Триазолил фенилбензолсульфонамиды
AU2007272972B2 (en) * 2006-07-14 2011-12-01 Chemocentryx, Inc. Triazolyl pyridyl benzenesulfonamides as CCR2 or CCR9 modulators for the treatment of atherosclerosis
WO2009008552A1 (en) 2007-07-11 2009-01-15 Taisho Pharmaceutical Co., Ltd. 8-aryl-4-alkylpyrrolo[2,3,4-de]quinolin-5(4h)-one and 8-aryl-4-alkyl-4,5-dihydropyrrolo[2,3,4-de]quinolin-5-ol derivatives
US20100256145A1 (en) * 2007-08-01 2010-10-07 H. Lundbeck A/S Use of kcnq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
ES2554513T3 (es) 2008-05-23 2015-12-21 Novartis Ag Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
US8415376B2 (en) 2008-05-30 2013-04-09 Amgen Inc. Inhibitors of PI3 kinase
JP2012513410A (ja) 2008-12-23 2012-06-14 アボット・ラボラトリーズ 抗ウイルス化合物
WO2011031896A2 (en) 2009-09-09 2011-03-17 Avila Therapeutics, Inc. Pi3 kinase inhibitors and uses thereof
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
CN103347520A (zh) 2010-10-13 2013-10-09 波士顿大学管理委员会 用作癌症化学治疗的晚期sv40因子（lsf）的抑制剂
KR101985184B1 (ko) 2011-01-28 2019-06-03 주식회사 동진쎄미켐 신규한 유기염료 및 이의 제조방법
TW201311149A (zh) 2011-06-24 2013-03-16 Ishihara Sangyo Kaisha 有害生物防治劑
US9307766B2 (en) 2011-08-25 2016-04-12 Syngenta Participations Ag Isoxazoline derivatives as insecticidal compounds
FR2981935B1 (fr) 2011-10-28 2015-08-07 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
MX372722B (es) * 2012-02-29 2020-06-19 Chemocentryx Inc Sulfonamidas de aza-aril 1h-pirazol-1-il benceno
AU2014360743C1 (en) 2013-12-02 2021-01-28 Chemocentryx, Inc. CCR6 compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006076644A2 (en) * 2005-01-14 2006-07-20 Chemocentryx, Inc. Heteroaryl sulfonamides and ccr2
CN101820881A (zh) * 2007-07-12 2010-09-01 坎莫森特里克斯公司 作为ccr2调节剂用于治疗炎症的稠合杂芳基吡啶基和苯基苯磺酰胺
WO2011119518A1 (en) * 2010-03-25 2011-09-29 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators

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JP6563947B2 (ja) 2019-08-21
IL245704A0 (en) 2016-07-31
IL245704B (en) 2019-10-31
AU2014360743A1 (en) 2016-05-26
EA201691141A1 (ru) 2017-01-30
US9795599B2 (en) 2017-10-24
AU2014360743C1 (en) 2021-01-28
ES2735360T3 (es) 2019-12-18
US20150175547A1 (en) 2015-06-25
US20180092902A1 (en) 2018-04-05
CA2930148A1 (en) 2015-06-11
EP3076968A1 (en) 2016-10-12
CA2930148C (en) 2023-04-11
EA029826B1 (ru) 2018-05-31
CN105960237A (zh) 2016-09-21
US10117865B2 (en) 2018-11-06
US10786494B2 (en) 2020-09-29
JP2016540051A (ja) 2016-12-22
WO2015084842A1 (en) 2015-06-11
MX2016007128A (es) 2016-08-11
US9340509B2 (en) 2016-05-17
EP3076968B1 (en) 2019-04-17
KR102331833B1 (ko) 2021-11-25
US20190167659A1 (en) 2019-06-06
KR20160096634A (ko) 2016-08-16
AU2014360743B2 (en) 2020-07-16
ZA201603167B (en) 2019-09-25
US20160296508A1 (en) 2016-10-13

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