CN105943858A - Traditional Chinese medicine for treating chronic movement or sound production tic disorder and preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating chronic movement or sound production tic disorder and a preparation method. The traditional Chinese medicine is prepared from pine among the Indian bread, piceous lactarius fruits, the all stem of Barleria lupulina, russula integra, devilpepper roots, herb of canscora lucidissima, silvery aleuritopteris, herb of rose glorybind, caragana microphylla, ficus esquiroliana, herb of pilose bushclover, folium apocyni veneti, roots of tragopogon pratensis, cladonia alpestris flowers, largeleaf tea, club bottle gourd fruits, herb of marsh orchis and cissus pteroclada hayata. The traditional Chinese medicine has the advantages that the traditional Chinese medicine can be combined with conventional western drugs to treat chronic movement or sound production tic disorder, the treatment effect of the western drugs is effectively improved, toxic and side effects are avoided, effect taking is fast, the toxic and side effects of the western drugs can be reduced, and the preparation process is simple.

Description

A kind of Chinese medicine treating chronic motor or vocal tic disorder and preparation method

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to one and treat chronic exercise or sounding is taken out The Chinese medicine of dynamic obstacle and preparation method.

Background technology

Twitch be a kind of imperious burst, quickly, repetition, non-rhythmic, mechanical single or multi-section Position muscle is twitched or sounding.Motion and sounding are twitched and all can be divided into simple and complicated two classes, but boundary is unclear. As nictation, torticollis, shrug, making faces etc. belongs to twitch of simply moving；Jump, jump, beat oneself etc. belong to Twitch in complicated motion.Clear larynx sound, roars, inhales nose action and belong to simple sounding and twitch, verbigeration, Echolalia, obscene words belong to complicated sounding and twitch.Various forms of twitches all can be in the short time by will control System, stress increase the weight of down, alleviates when sleep or disappears.Multiple being born in the Childhood, minority is sustainable To growing up.According to age of onset, clinical manifestation, course of disease length with whether twitch with sounding and be divided into: Gilles de la Tourette's syndrome, chronic motor or vocal tic disorder, Tourette syndrome.Chronic exercise or sounding are twitched Obstacle (chronicmotororvocal ticdisorder) is to be limited to one group of muscle or two groups of muscle groups Moving or sounding twitches a kind of tic disorder that (but both not and deposit) is characterized, twitch can be Single may also be multiple (the most multiple), continue more than 1 year.

Chinese medicine is thought, primary disease belongs to the scopes such as paralysis, chronic infantile convulsion, tic, liver-wind syndrome.Primary disease is sick Because mostly being innate deficiency, overaction of the five emotions, the closest with liver relation, have with the heart, spleen, kidney and lungs again Close relationship.Motherland's medical science thinks the pure sun of children's's ferritic, " YANG often being in excess and deficiency of YIN ", and " liver is normal Have a surplus ".It is not normal that primary disease is mainly function, because of infant many eatings fry and delicious food savoury, makes body fluid More lose, cause the deficiency of YIN, thus occur disturbing on endogenous fire, a series of involuntary twitch of excessive rising of liver-YANG.

Summary of the invention

The technical problem to be solved is, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of Determined curative effect and the little treatment Chinese medicine of chronic motor or vocal tic disorder of toxic action and preparation method.

In order to solve above-mentioned technical problem, the invention provides one and treat chronic exercise or sounding twitch barrier The Chinese medicine hindered, described Chinese medicine includes following raw medicinal material: Lignum Poria, black breast mushroom, lancing is red, variable color is red Mushroom, Radix Rauvolfiae, Herba Canscorae, Aleuritopteris argentea (Gmel.) Fee, Herba Calystegiae Japonicae, Herba Caraganae intermediae, Ficus fulva Reinw., Herba lespedezae pilosae, Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Camellia sinensis O. Ktze. Var. macrophylla Sieb., Pericarpium Lagenariae hispidae, Herba Orchidis Latifoliae and Cissus pteroclada Hayata.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Lignum Poria 20～30 Part, black breast mushroom 25～35 parts, red 15～30 parts of lancing, variable color Russula 5～15 parts, Radix Rauvolfiae 15～ 25 parts, Herba Canscorae 10～20 parts, Aleuritopteris argentea (Gmel.) Fee 25～35 parts, Herba Calystegiae Japonicae 5～15 parts, Herba Caraganae intermediae 15～25 Part, Ficus fulva Reinw. 10～20 parts, Herba lespedezae pilosae 15～30 parts, Folium Apocyni Veneti 5～15 parts, Pedicularis rex C. B. Clarke ex Maxim. 15～ 25 parts, Cladonia alpestris (L.) Rabenh. 20～30 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 5～15 parts, Pericarpium Lagenariae hispidae 25～35 parts, Herba Orchidis Latifoliae 10～20 Part and Cissus pteroclada Hayata 15～25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Lignum Poria 25～30 parts, black breast mushroom 30～35 parts, red 20～25 parts of lancing, variable color Russula 5～10 parts, Luo Fu 20～25 parts of wood, Herba Canscorae 15～20 parts, Aleuritopteris argentea (Gmel.) Fee 30～35 parts, Herba Calystegiae Japonicae 10～15 parts, lemon Bar 20～25 parts, Ficus fulva Reinw. 15～20 parts, Herba lespedezae pilosae 20～25 parts, Folium Apocyni Veneti 5～10 parts, also Sun grass roots 15～20 parts, Cladonia alpestris (L.) Rabenh. 25～30 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 10～15 parts, Pericarpium Lagenariae hispidae 30～35 parts, red Door blue 10～15 parts and Cissus pteroclada Hayata 20～25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Lignum Poria 26 parts, black breast 35 parts of mushroom, red 21 parts of lancing, variable color Russula 9 parts, Radix Rauvolfiae 25 parts, Herba Canscorae 16 parts, Aleuritopteris argentea (Gmel.) Fee 31 parts, Herba Calystegiae Japonicae 12 parts, Herba Caraganae intermediae 25 parts, Ficus fulva Reinw. 17 parts, Herba lespedezae pilosae 21 Part, Folium Apocyni Veneti 9 parts, Pedicularis rex C. B. Clarke ex Maxim. 16 parts, Cladonia alpestris (L.) Rabenh. 29 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 11 parts, Pericarpium Lagenariae hispidae 35 parts, Herba Orchidis Latifoliae 12 parts and Cissus pteroclada Hayata 25 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 5～the alcohol of 6 times Concentration is the ethanol of 80%～95%, is heated to boiling reflux 4～6 hours, filters, is molten with backflow Agent, with filtering residue as solute, uses percolation with the speed slowly percolation of per minute 1～2ml, collects percolation Liquid, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa, relative density is The mastic of 1.05～1.10, is spray-dried, and the inlet temperature 160 of spray dryer～175 DEG C, goes out pathogenic wind-warm Spend 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, is mixed red to Lignum Poria, black breast mushroom, lancing, variable color Russula and Radix Rauvolfiae in described ratio Close, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heating and refluxing extraction 2～ 4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, it is centrifuged remove impurity with tube centrifuge, When extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is The medicinal liquid of 1.05～1.10, will concentrate after concentrated solution spray dryer be dried, be ground into subsequently 100～ 200 mesh, it is thus achieved that dry powder；

Second step, by Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Herba Orchidis Latifoliae and Cissus pteroclada Hayata in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed surplus stock medical material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter, filtrate Merging, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, in 55 DEG C～ 65 DEG C of reduced vacuum are dried, and obtain dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～5 Times water dissolution, with 40% sodium hydroxide solution regulate pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 35～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3%, parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

Beneficial effects of the present invention: the Chinese medicine of the present invention can be combined conventional western medicine treatment chronic exercise or send out Sound tic disorder, is effectively improved the therapeutic effect of Western medicine, has no side effect, instant effect, can subtract simultaneously The toxic and side effects of Shaoxi medicine, preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine treating chronic motor or vocal tic disorder, Chinese medicine include with Lower raw medicinal material: Lignum Poria, black breast mushroom, lancing are red, variable color Russula, Radix Rauvolfiae, Herba Canscorae, stimulate the menstrual flow Grass, Herba Calystegiae Japonicae, Herba Caraganae intermediae, Ficus fulva Reinw., Herba lespedezae pilosae, Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Camellia sinensis O. Ktze. Var. macrophylla Sieb., Pericarpium Lagenariae hispidae, Herba Orchidis Latifoliae and Cissus pteroclada Hayata.The pharmacology of various raw medicinal materials is as follows:

Lignum Poria: [another name] yellow pine joint, Lignum Pini Nodi, Fu Shenxin, Poria cum Radix Pini's heart wood, poria wood.[source] Medical material Ji Yuan: for the Radix Pini massonianae in the middle of On Polyporaceae poria cocos sclerotium.[nature and flavor] are sweet；Property flat.[return Warp] liver；Heart channel.[function cures mainly] suppressing the hyperactive liver is calmed the nerves.Main palpitation with fear is forgetful；Apoplexy language is not smoothgoing；Tinea pedis is had a cramp. [each discussion] 1. " property of medicine opinion ": controlling middle hemiplegia, actinal surface is drunk tiltedly, poison wind clonic spasm of the muscle, in silence, and the mind Frightened pull, empty and forgetful.2. " Chinese medicinal herbal ": mind tranquilizing and the heart calming.[extracts] " China's book on Chinese herbal medicine "

Black breast mushroom: [source] medical material Ji Yuan: for the sporophore of Russulaceae fungus drip blue milk mushroom.[property Taste] pungent；Sweet；Warm in nature.[function cures mainly] expelling wind and cold；Relaxing muscles and tendons and activating QI and blood in the collateral.Main air pain of dampness syndrome；Extremity Numb；Tetany.[extracts] " China's book on Chinese herbal medicine "

Lancing is red: [another name] Herba Moslae Cavaleriei, bloody path grass.[source] medical material Ji Yuan: for acanthaceous plant The Herb of Herba Barleriae prioniitis.[nature and flavor] acrid in the mouth；Bitter；Property flat.[function cures mainly] the meridian dredging；Continuous muscle Bone；Removing toxic substances and promoting subsidence of swelling.Main treating swelling and pain by traumatic injury；Fracture；Traumatic hemorrhage；Carbuncle sore tumefacting virus；Venom.[pluck Record] " China's book on Chinese herbal medicine "

Variable color Russula: [another name] mushroom.[source] medical material Ji Yuan: for Russulaceae fungus full edge Russula Sporophore.[nature and flavor] are pungent；Micro-salty；Property flat.[function cures mainly] expelling wind and cold；Relaxing muscles and tendons and activating QI and blood in the collateral. Main air pain of dampness syndrome；Numb hand and foot；Tic of the limbs.[extracts] " China's book on Chinese herbal medicine "

Radix Rauvolfiae: [another name] taberpsychine, mountain Horse hoof, Fructus Linderae Glaucae, rauwolfia, fish gallbladder ferrum sheep wooden, malicious Dung, Cornu Caprae seu Ovis hairpin.[source] medical material Ji Yuan: for the root of apocynaceae plant Radix Rauvolfiae.[nature and flavor] are bitter； Micro-pungent；Cool in nature.[function cures mainly] heat clearing away；Blood pressure lowering；Allay excitement.Main cold, fever；Headache body pain；Pharynx Larynx swells and ache；Hypertension；Dizziness；Insomnia.[each discussion] " Guangxi Chinese medicinal herbal ": eliminating pathogen in the liver pathogenic fire reducing. Control hypertension, headache, wind heat eruptive disease.[extracts] " China's book on Chinese herbal medicine "

Herba Canscorae: [another name] wears money grass, top heart-wind syndrome, lion grass, Herba Andrographis.[source] medical material base Source: for the herb of gentianaceae plant Herba Canscorae.[nature and flavor] are micro-sweet；Micro-hardship；Cool in nature.[return through] lung； Spleen；Stomach；Liver Channel.[function cures mainly] heat-clearing and toxic substances removing；Vital energy regualting and blood circulation-promoting.Main cough due to lung-heat；Hepatitis；Hook Leptospiral is sick；Chest pain；Stomachache；Traumatic injury；Venom.[each discussion] " Guangxi medium-height grass Medicine ": regulate the flow of vital energy, pain relieving, cough-relieving.Control cough due to lung-heat, heart peratodynia, venom.[extracts] " in China's book on Chinese herbal medicine "

Aleuritopteris argentea (Gmel.) Fee: [another name] Herba Melicae Scabrosae, spasmolytic grass, gold thread copper sheet, gagger grass, Herba Lycopodii, return to life from the nether world Ginseng, Herba Polygalae Telephioidis, leaf roll Herba Pteridis Multifidae.[source] medical material Ji Yuan: for Sinopteridaceae plant Aleuritopteris argentea (Gmel.) Fee Herb.[nature and flavor] are pungent；Sweet；Flat.[return through] lung；Liver Channel.[function cures mainly] expelling phlegm for arresting cough； Promoting blood circulation to restore menstrual flow；Dampness removing；Removing toxic substances and promoting subsidence of swelling.Main cough；Menoxenia；Amenorrhea is suffered from abdominal pain；Leucorrhea with red and white discharge；Lung Consumptive disease hemoptysis；Loose stool and diarrhea；Difficulty and pain in micturition；Lung abscess；Acute mastitis；Rheumatic arthritis；Traumatic injury；Intercostal Neuralgia；Epidemic hemorrhagic conjunctivitis；Skin ulcer swells.[each discussion] " Henan Chinese herbal medicine handbook ": promoting blood flow to regulate menstruation, Damp eliminating, cold expelling, pain relieving.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Herba Calystegiae Japonicae: [another name] DAWANHUA, husband's Seedling, Canis familiaris L. baby's seedling, the perverse pattern of horse.[source] medical material base Source: for root and the herb of plant Japan of dicotyledon scammonia section sky sword.[nature and flavor] are sweet；Cold.[return Warp] spleen；Stomach；Large intestine；Small intestine meridian.[function cures mainly] removing heat from the liver；YIN nourishing；Diuresis.Main liver-yang Rising；Dizzy；Dizzy；Dysuria.[extracts] " China's book on Chinese herbal medicine "

Herba Caraganae intermediae: [another name] horse collection bavin, Herba Damnacanthi.[source] medical material Ji Yuan: in the middle of leguminous plant The herb of caragana.[nature and flavor] are sweet；Temperature.[return through] liver；Kidney channel.[function cures mainly] YIN nourishing is mended Blood, invigorates blood circulation.Main menoxenia.[each discussion] " soft science in China medicinal plants ": YIN nourishing is supported Blood.[extracts] " China's book on Chinese herbal medicine "

Ficus fulva Reinw.: [another name] soil Cortex Mori, Herba Fici Simplicissimae, Mapo wind, shake wind, crow wind greatly.[come Source] medical material Ji Yuan: for the root bark of moraceae plants Ficus fulva Reinw..[nature and flavor] are sweet；Property flat.[function cures mainly] Replenishing QI to invigorate the spleen；Expelling wind and removing dampness.Cure mainly the deficiency of vital energy,；The prolapse of the uterus；Proctoptosis；Loose stool；Edema；Rheumatic arthralgia. [each discussion] " Xinhua's book on Chinese herbal medicine outline ": root bark: sweet in the mouth, property are flat.There is invigorating the spleen and benefiting QI, invigorate blood circulation and dispel Effect of wind.For deficient qi and blood, uterine prolapse, proctoptosis, rheumatic arthralgia, the disease such as have loose bowels.[extracts] " China's book on Chinese herbal medicine "

Herba lespedezae pilosae: [another name] Semen arachidis hypogaeae, SANYE rattan, Herba cassiae torae, money rattan, wild flower grass, artificial hillock bean, Ipomoea bonanox, Herba Fici Simplicissimae.[source] medical material Ji Yuan: for the whole herb with root of leguminous plant Herba lespedezae pilosae.[property Taste] bitter；Pungent；Property flat.[return through] spleen；Heart channel.[function cures mainly] benefiting vital QI for tranquillizing；Promoting blood circulation and stopping pain； Inducing diuresis to remove edema；Removing toxic substances dissipates.Main heat of shooting without hitting the target；Insomnia；Acute filthy disease is suffered from abdominal pain；Rheumatic arthralgia；Edema；Scrofula； Swollen ulcer drug.[extracts] " China's book on Chinese herbal medicine "

Folium Apocyni Veneti: [another name] ambary, bluish dogbane, red building, wild flax, Gaster caprae seu Ovis draw angle, Herba Euphorbiae Helioscopiae fiber crops. [source] this product is the dried leaves of apocynaceae plant Herba Apocyni veneti.[nature and flavor] sweet, bitter, cold.[return Warp] return Liver Channel.[function cures mainly] suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, Edema oliguria；Hypertension, neurasthenia, nephritis edema.[extracts] " Chinese Pharmacopoeia "

Pedicularis rex C. B. Clarke ex Maxim.: [source] medical material Ji Yuan: for the root of goatweed Pedicularis rex.[nature and flavor] Taste is micro-sweet；Cool in nature.[return through] liver；Spleen channel.[function cures mainly] invigorating qi and benefiting blood；Invigorating spleen to remove dampness.Main Deficiency of YIN hectic fever；Puerperal hypogalactia；Chronic hepatitis；Cirrhotic ascites；Infantile malnutrition.[extracts] " in China's book on Chinese herbal medicine "

Cladonia alpestris (L.) Rabenh.: [source] medical material Ji Yuan: for the dendrimer of Cladoniaceae plant Herba Cladoniae rangiferinae.[nature and flavor] are light； Property flat.[return through] liver；Stomach warp.[function cures mainly] suppressing the hyperactive liver improving eyesight；Blood-arresting catamenia-regulating.Main wind-yang and up-boring； Have a dizzy spell；Migraine；Mesh disease；Epistaxis；Menstruation is inconsiderate；Leucorrhea.[extracts] " China's book on Chinese herbal medicine "

Camellia sinensis O. Ktze. Var. macrophylla Sieb.: [another name] is crossed sieve, arrested sieve, thing sieve, melon reed, bitter a large bamboo or straw hat with a concial crown, broard brim and handle, hardship.[source] medical material Ji Yuan: for the leaf of plant of theaceae Camellia sinensis O. Ktze. Var. macrophylla Sieb..[nature and flavor] are bitter；Cold.[return through] heart；Liver；Lung；Wing Guang warp.[function cures mainly] clearing heat and relieving fidgetness；Quench the thirst；Improving eyesight.Main dysphoria with smothery sensation is had a headache；Thirsty；Blurred vision；Pharynx Larynx swells and ache；Drench pain.[each discussion] supplement to the Herbal: boil as drinking, improving eyesight of quenching the thirst, relieving restlessness, no Sleep, expectorant.[extracts] " China's book on Chinese herbal medicine "

Pericarpium Lagenariae hispidae: [another name] sweet a kind of edible gourd, a sweet a kind of edible gourd, the mallet that clears the streets of people and traffic, imperial close melon, sky melon, a long a kind of edible gourd, flat Pu.[come Source] medical material Ji Yuan: for the fruit of cucurbitaceous plant Pericarpium Lagenariae hispidae.[nature and flavor] sweet in the mouth；Property flat.[function master Control] diuretic；Heat clearing away；Quench the thirst；Relieving restlessness.Main edema abdominal distention, dysphoria with smothery sensation is thirsty；Sore.[each discussion] Tang Materia Medica: tonneau water channel, the heat that disappears of quenching the thirst.[extracts] " China's book on Chinese herbal medicine "

Herba Orchidis Latifoliae: [source] medical material Ji Yuan: for the herb of orchid width leaf Herba Orchidis Latifoliae.[nature and flavor] Sweet；Flat.[return through] heart；Kidney；Stomach warp.[function cures mainly] tonifying kidney and nourishing yin；Invigorating spleen and reinforcing stomach.Main the moon Chronic consumptive disease heat；Irritated thirsty；Anorexia；Menoxenia.[each discussion] " Inner Mongol Chinese herbal medicine ": Heart tonifying, the kidney invigorating, promote the production of body fluid, quench the thirst, strengthening the spleen and stomach, control irritated thirsty, anorexia, YIN-fluid being insufficient, the moon Through uncomfortable.[extracts] " China's book on Chinese herbal medicine "

Cissus pteroclada Hayata: [another name] red Herba Lycopodii, Herba Alyxiae Sinensis, root rattan, soft muscle rattan, Radix seu Caulis fici Martinii, Fang Teng, Red Cissus pteroclada Hayata, wing branch Cissus repens.[source] medical material Ji Yuan: for the rattan of vitaceae halberd leaf Cissus repens Stem.[nature and flavor] are pungent；Micro-hardship；Property flat.[return through] Liver Channel.[function cures mainly] expelling wind and removing dampness；Live Blood dredging collateral.Main air pain of dampness syndrome；Lumbar muscle strain；Limb paralysis；Traumatic injury.[each discussion] is " wide Western Chinese medicinal herbal ": relaxing muscles and tendons and activating QI and blood in the collateral, eliminating blood stasis to promote regeneration of blood.Control internal traumatic injury, grain contracture.[extracts] " in China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Lignum Poria 20～30 Part, black breast mushroom 25～35 parts, red 15～30 parts of lancing, variable color Russula 5～15 parts, Radix Rauvolfiae 15～ 25 parts, Herba Canscorae 10～20 parts, Aleuritopteris argentea (Gmel.) Fee 25～35 parts, Herba Calystegiae Japonicae 5～15 parts, Herba Caraganae intermediae 15～25 Part, Ficus fulva Reinw. 10～20 parts, Herba lespedezae pilosae 15～30 parts, Folium Apocyni Veneti 5～15 parts, Pedicularis rex C. B. Clarke ex Maxim. 15～ 25 parts, Cladonia alpestris (L.) Rabenh. 20～30 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 5～15 parts, Pericarpium Lagenariae hispidae 25～35 parts, Herba Orchidis Latifoliae 10～20 Part and Cissus pteroclada Hayata 15～25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Lignum Poria 25～30 parts, black breast mushroom 30～35 parts, red 20～25 parts of lancing, variable color Russula 5～10 parts, Luo Fu 20～25 parts of wood, Herba Canscorae 15～20 parts, Aleuritopteris argentea (Gmel.) Fee 30～35 parts, Herba Calystegiae Japonicae 10～15 parts, lemon Bar 20～25 parts, Ficus fulva Reinw. 15～20 parts, Herba lespedezae pilosae 20～25 parts, Folium Apocyni Veneti 5～10 parts, also Sun grass roots 15～20 parts, Cladonia alpestris (L.) Rabenh. 25～30 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 10～15 parts, Pericarpium Lagenariae hispidae 30～35 parts, red Door blue 10～15 parts and Cissus pteroclada Hayata 20～25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Lignum Poria 26 parts, black breast 35 parts of mushroom, red 21 parts of lancing, variable color Russula 9 parts, Radix Rauvolfiae 25 parts, Herba Canscorae 16 parts, Aleuritopteris argentea (Gmel.) Fee 31 parts, Herba Calystegiae Japonicae 12 parts, Herba Caraganae intermediae 25 parts, Ficus fulva Reinw. 17 parts, Herba lespedezae pilosae 21 Part, Folium Apocyni Veneti 9 parts, Pedicularis rex C. B. Clarke ex Maxim. 16 parts, Cladonia alpestris (L.) Rabenh. 29 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 11 parts, Pericarpium Lagenariae hispidae 35 parts, Herba Orchidis Latifoliae 12 parts and Cissus pteroclada Hayata 25 parts.

When the dosage form of described Chinese medicine is granule, and it comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 5～the alcohol of 6 times Concentration is the ethanol of 80%～95%, is heated to boiling reflux 4～6 hours, filters, is molten with backflow Agent, with filtering residue as solute, uses percolation with the speed slowly percolation of per minute 1～2ml, collects percolation Liquid, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa, relative density is The mastic of 1.05～1.10, is spray-dried, and the inlet temperature 160 of spray dryer～175 DEG C, goes out pathogenic wind-warm Spend 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

When the dosage form of described Chinese medicine is syrup, and it comprises the following steps:

The first step, is mixed red to Lignum Poria, black breast mushroom, lancing, variable color Russula and Radix Rauvolfiae in described ratio Close, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heating and refluxing extraction 2～ 4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, it is centrifuged remove impurity with tube centrifuge, When extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is The medicinal liquid of 1.05～1.10, will concentrate after concentrated solution spray dryer be dried, be ground into subsequently 100～ 200 mesh, it is thus achieved that dry powder；

Second step, by Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Herba Orchidis Latifoliae and Cissus pteroclada Hayata in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed surplus stock medical material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter, filtrate Merging, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, in 55 DEG C～ 65 DEG C of reduced vacuum are dried, and obtain dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～5 Times water dissolution, with 40% sodium hydroxide solution regulate pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 35～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3%, parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this Execute.

Embodiment 1: granule prepared by the present invention

Take Lignum Poria 260g, black breast mushroom 350g, the red 210g of lancing, variable color Russula 90g, Radix Rauvolfiae 250g, Herba Canscorae 160g, Aleuritopteris argentea (Gmel.) Fee 310g, Herba Calystegiae Japonicae 120g, Herba Caraganae intermediae 250g, Ficus fulva Reinw. 170g, Herba lespedezae pilosae 210g, Folium Apocyni Veneti 90g, Pedicularis rex C. B. Clarke ex Maxim. 160g, Cladonia alpestris (L.) Rabenh. 290g, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 110g, Pericarpium Lagenariae hispidae 350g, Herba Orchidis Latifoliae 120g and Cissus pteroclada Hayata 250g.

Its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, add relative to 6 times of mixture is pure and strong Degree is the ethanol of 80%, is heated to boiling reflux 6 hours, filters, with backflow as solvent, with filtering residue For solute, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, subsequently very Being evaporated to relative density when 60 DEG C under reciprocal of duty cycle 0.07Mpa is the mastic of 1.10, is spray-dried, spray The inlet temperature of mist drying machine 175 DEG C, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: obtain dried cream powder in add relative to dried cream powder quality 0.25 times cane sugar powder and The dextrin of 0.16 times, makes granule, is dried in 50 DEG C, it is thus achieved that granule.

Embodiment 2: syrup prepared by the present invention

Take Lignum Poria 290g, black breast mushroom 310g, the red 250g of lancing, variable color Russula 60g, Radix Rauvolfiae 220g, Herba Canscorae 170g, Aleuritopteris argentea (Gmel.) Fee 350g, Herba Calystegiae Japonicae 150g, Herba Caraganae intermediae 210g, Ficus fulva Reinw. 190g, Herba lespedezae pilosae 250g, Folium Apocyni Veneti 70g, Pedicularis rex C. B. Clarke ex Maxim. 180g, Cladonia alpestris (L.) Rabenh. 260g, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 150g, Pericarpium Lagenariae hispidae 320g, Herba Orchidis Latifoliae 150g and Cissus pteroclada Hayata 210g.

Its preparation method comprises the following steps:

The first step, is mixed red to Lignum Poria, black breast mushroom, lancing, variable color Russula and Radix Rauvolfiae in described ratio Close, add the ethanol that determining alcohol is 90% relative to 5 times of mixture, heating and refluxing extraction 2 times, every time Reflux, extract, 3 hours, united extraction liquid, it is centrifuged remove impurity with tube centrifuge, by the extracting solution after remove impurity Being evaporated to relative density when 60 DEG C under conditions of 65 DEG C is the medicinal liquid of 1.08, will concentrate after dense Contracting liquid spray dryer is dried, and is ground into 200 mesh subsequently, it is thus achieved that dry powder；

Second step, by Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Herba Orchidis Latifoliae and Cissus pteroclada Hayata in described ratio Mixing, is ground into powder, with the ethanol that determining alcohol is 95% as solvent, impregnates 48 hours, and employing is oozed Method of filtering, with the speed slowly percolation of 1ml per minute, collects percolate, and when being concentrated into 60 DEG C, relative density is The mastic of 1.27, is dried with spray dryer, is ground into 200 mesh subsequently, it is thus achieved that dry powder, is added The quality of ethanol is 5 times of second step mixture quality；

3rd step, is mixed surplus stock medical material in described ratio, adds pure and strong relative to mixture 4 times amount Degree is the alcohol reflux 2 times of 80%, each 2 hours, filters, and filtrate merges, and reclaims ethanol, When being concentrated into 60 DEG C, relative density is the mastic of 1.22, is dried in 65 DEG C of reduced vacuum, obtains dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3 times Water dissolution, with 40% sodium hydroxide solution regulation pH value to 7.0, be subsequently added correctives sucrose, anti- Rotten agent mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 40%, ethyl hydroxybenzoate 0.05%.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20-30g, carries out acute poison Property test.Mice is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours before experiment, incite somebody to action this The Chinese medicine granules of inventive embodiment 1 preparation is dissolved in water, (concentration is 8.54g crude drug/ml, High concentration) gavage, gavage volume is 5ml/kg (i.e. unit dosage form is 42.7 crude drugs/kg), right Give normal saline according to group, within one day, be administered 2 times, delivery time 6 hours, after administration continuously Observe 14 days, and record mice toxic reaction and death toll.Test result indicate that: with matched group ratio Relatively, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, Drinking-water, body weight increase the most normal.Granule LD50 > 42.7 crude drugs/the kg of the Mouse oral gavage present invention, Every day, maximum dosage-feeding was 85.4 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention is 8.37g crude drug / day/people, adult's body weight is in terms of 60KG, and average dosage is 0.1395g crude drug/kg/ day.By body weight Meter: the dosis tolerata of the Chinese medicine of mice (average weight is in terms of 25g) the oral administration gavage present invention is as quantity 612 times.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: three groups of mices (often group 20) are pressed by Chinese medicine embodiment 1 granule of the present invention 12.37,25.41 and 43.29g crude drugs/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 Secondary) and drug withdrawal 3 weeks after, result shows: Chinese medicine of the present invention is to the hair of mice, behavior, defecation, body The indexs such as weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, internal organs meat Eye does not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, and mice Each internal organs are all without substantially changing.Illustrate that Chinese medicine of the present invention is little, after drug withdrawal also to toxicity after mice long-term prescription There is no difference reaction, application safety.

Clinical data:

Case selection: all 112 selected example cases derive from this Out-patient Department and the tic disorder being in hospital Patient, all meets the diagnostic criteria of chronic motor or vocal tic disorder.All patients are randomly divided into two Group, treatment group and each 56 examples of matched group.In treatment group 56 example, male 39 examples, female 17 example；Age 4～ 14 years old；The course of disease 1～5 years.In matched group 56 example, male 37 examples, female 19 example, age 4～15 years old； The course of disease 1～4 years.Treatment group is poor without significance in sex, age, the course of disease and clinical symptoms with matched group Different, there is comparability.

Diagnostic criteria: with reference to " clinical disease diagnosis and curative effect judging standard ", 1, symptom standard: not from Main motion twitch or sounding, can not simultaneously exist, and within normal 1 day, occurs repeatedly, can every day or interruption appearance. 2, serious standard: do not had the catabasis of persistently more than 2 months in 1 year.3, course of disease standard: 18 years old Front onset, continues 1 year the most.4, exclusion criteria: be not due to Tourette syndrome, little dance Step caused by disease, medicine or nervous system Other diseases.

Therapeutic Method:

Matched group: routine gives haloperidol, predose is 0.05mg/kg d, divides and takes for 2-3 time, 0.5mg can be increased at interval of 3-5 days according to infant situation, but maximal dose every day not can exceed that 6mg/d； In order to reduce the side effect of haloperidol, give the benzhexol hydrochloride sheet of equivalent simultaneously；Within 3 months, it is one The course for the treatment of.

Treatment group: on the basis of matched group western medicine routine treatment, oral Chinese medicine embodiment 1 granule of the present invention Agent, each 20g, three times a day；It within 3 months, it is a course for the treatment of.

Two groups of patients all use Western medicine colligation to treat, and focus on the psychological consultation of two groups of patients simultaneously, support, Help patient to eliminate Mental health problem, reduce anxiety, depressive emotion, adapt to actual environment.

Curative effect judging standard: " clinical disease diagnosis and curative effect judging standard " (1) fully recovers: chronic exercise Or sounding twitches symptom complete incidence graph or substantially disappear, follow up a case by regular visits to half a year without recurrence.(2) take a turn for the better: motion is taken out Dynamic, sounding twitches clinical symptom relief, twitches number of times and reduces, or PR.(3) invalid: disease Shape is without alleviating or adding severe one.

Therapeutic outcome: after two groups are treated two courses for the treatment of respectively, statistical result sees Tables 1 and 2.

Clinical efficacy comparison (unit: example) after treating 6 months respectively organized by 1 liang of table

Group	Number of cases	Cure	Take a turn for the better	Invalid	Total effective rate
						Treatment group	56	38	16	2	54 (96.43%)
Matched group	56	26	22	8	48 (85.71%)

As it can be seen from table 1 treatment group use the present invention Chinese medicine, coordinate western medical treatment chronic exercise or Sounding tic disorder, relative to matched group, on therapeutic effect, has and is markedly improved.

The treatment respectively of 2 liang of table group cures number after 6 months and the time compares (unit: example/%)

Group	Number of cases	Treat 2 months	Treat 4 months	Treat 6 months
					Treatment group	38	12 (21.43%)	25 (44.64%)	38 (67.86%)
Matched group	26	7 (12.5%)	15 (26.79%)	26 (46.43%)

From table 2 it can be seen that treatment group use the present invention Chinese medicine, coordinate western medical treatment chronic exercise or Sounding tic disorder, relative to matched group, not only better efficacy, takes effect the most faster.

According to the clinical statistics in toxicity test and above table, the Chinese medicine that the present invention provides has The advantage that safe without toxic side effect, effective percentage are high, rapid-action；Simultaneously according to clinical observation, during treatment, Matched group 56 example patient, there is xerostomia in 10 example patients, and blurred vision occur in 7 examples, and 4 examples occur weak, 2 examples occur dizzy, drowsiness, and feeling sick occurs in 1 example, and hepatic and renal function injure does not all occur or other are the worst Reaction；Treatment group 56 example patient, there is xerostomia in 4 example patients, and blurred vision occur in 2 examples, and 1 example occurs Weak, hepatic and renal function injure or other obvious adverse reaction all do not occur.Chinese medicine the most of the present invention is improving west While medicine therapeutic effect, additionally it is possible to reduce the side effect of Western medicine.

Relapse rate is added up: the 26 example patients that the 38 example patients curing treatment group and matched group are cured divide Not following up a case by regular visits to 12 months, result is added up, and treatment group 38 example recurs 2 examples, and relapse rate is 5.26%；Right According to organizing 26 examples, recur 6 examples, relapse rate 23.08%.

Concrete case: infant high certain, man, 7 years old, there is limb because happening suddenly without obvious inducement before 2 years in patient The ictal twitch of body, it is main for starting to twitch for double upper limb, and outbreak twitch is to arrive for several times for 1 time every time, Do not give special handling at the beginning, gradually develop into extremity twitch, during twitch, trunk is backward, abdominal part forward, on Limb is backward upper to be stretched, lower limb to the kicking shape that moves ahead, before outbreak between have chest uncomfortable and dizziness, outbreak Time conscious, without the symptom such as numbness of hands and feet, limb spasm.Rise and the most once sought medical advice at local hospital, intend It is diagnosed as " upper respiratory tract infection, function of nervous system's disease ", gives symptomatic treatment (concrete deficient detailed) symptom afterwards Slightly improve, but still have outbreak, the most in hospital diagnosis and treatment.It is diagnosed as chronic exercise through clinical assay health check-up or sends out Sound tic disorder.Give doctor trained in Western medicine haloperidol and the treatment of benzhexol hydrochloride sheet, inventive embodiments is administered orally simultaneously The granule of 1, each 20g, three times a day, after taking 4 months, chronic exercise is twitched symptom and is substantially disappeared Lose, cure, follow up a case by regular visits to 12 months without recurrence.

All above-mentioned primary implement these intellectual properties, do not set limit other forms enforcement this Plant new product or new method.Those skilled in the art will utilize this important information, and foregoing is revised, To realize similar implementation status.But, all modifications or transformation belong to reservation based on new product of the present invention Right.

The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention, Still fall within the protection domain of technical solution of the present invention.

Claims (8)

1. the Chinese medicine treating chronic motor or vocal tic disorder, it is characterised in that described middle medicated bag Include following raw medicinal material: Lignum Poria, black breast mushroom, lancing are red, variable color Russula, Radix Rauvolfiae, Herba Canscorae, Aleuritopteris argentea (Gmel.) Fee, Herba Calystegiae Japonicae, Herba Caraganae intermediae, Herba lespedezae pilosae, Folium Apocyni Veneti, Ficus fulva Reinw., Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Camellia sinensis O. Ktze. Var. macrophylla Sieb., Pericarpium Lagenariae hispidae, Herba Orchidis Latifoliae and Cissus pteroclada Hayata.

2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of described raw medicinal material For: Lignum Poria 20～30 parts, black breast mushroom 25～35 parts, red 15～30 parts of lancing, variable color Russula 5～ 15 parts, Radix Rauvolfiae 15～25 parts, Herba Canscorae 10～20 parts, Aleuritopteris argentea (Gmel.) Fee 25～35 parts, Herba Calystegiae Japonicae 5～ 15 parts, Herba Caraganae intermediae 15～25 parts, Ficus fulva Reinw. 10～20 parts, Herba lespedezae pilosae 15～30 parts, Folium Apocyni Veneti 5～ 15 parts, Pedicularis rex C. B. Clarke ex Maxim. 15～25 parts, Cladonia alpestris (L.) Rabenh. 20～30 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 5～15 parts, Pericarpium Lagenariae hispidae 25～35 Part, Herba Orchidis Latifoliae 10～20 parts and Cissus pteroclada Hayata 15～25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the weight portion of described raw medicinal material Number ratio is: Lignum Poria 25～30 parts, black breast mushroom 30～35 parts, red 20～25 parts of lancing, variable color Russula 5～10 parts, Radix Rauvolfiae 20～25 parts, Herba Canscorae 15～20 parts, Aleuritopteris argentea (Gmel.) Fee 30～35 parts, Herba Calystegiae Japonicae 10～15 parts, Herba Caraganae intermediae 20～25 parts, Ficus fulva Reinw. 15～20 parts, Herba lespedezae pilosae 20～25 parts, Herba Apocyni veneti Leaf 5～10 parts, Pedicularis rex C. B. Clarke ex Maxim. 15～20 parts, Cladonia alpestris (L.) Rabenh. 25～30 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 10～15 parts, Pericarpium Lagenariae hispidae 30～35 parts, Herba Orchidis Latifoliae 10～15 parts and Cissus pteroclada Hayata 20～25 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the weight portion of described raw medicinal material Number ratio is: Lignum Poria 26 parts, black breast 35 parts of mushroom, red 21 parts of lancing, variable color Russula 9 parts, Radix Rauvolfiae 25 parts, Herba Canscorae 16 parts, Aleuritopteris argentea (Gmel.) Fee 31 parts, Herba Calystegiae Japonicae 12 parts, Herba Caraganae intermediae 25 parts, Ficus fulva Reinw. 17 Part, Herba lespedezae pilosae 21 parts, Folium Apocyni Veneti 9 parts, Pedicularis rex C. B. Clarke ex Maxim. 16 parts, Cladonia alpestris (L.) Rabenh. 29 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 11 Part, Pericarpium Lagenariae hispidae 35 parts, Herba Orchidis Latifoliae 12 parts and Cissus pteroclada Hayata 25 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is granule Agent, its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 5～the alcohol of 6 times Concentration is the ethanol of 80%～95%, is heated to boiling reflux 4～6 hours, filters, is molten with backflow Agent, with filtering residue as solute, uses percolation with the speed slowly percolation of per minute 1～2ml, collects percolation Liquid, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa, relative density is The mastic of 1.05～1.10, is spray-dried, and the inlet temperature 160 of spray dryer～175 DEG C, goes out pathogenic wind-warm Spend 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

6. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is syrup Agent, its preparation method comprises the following steps:

The first step, is mixed red to Lignum Poria, black breast mushroom, lancing, variable color Russula and Radix Rauvolfiae in described ratio Close, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heating and refluxing extraction 2～ 4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, it is centrifuged remove impurity with tube centrifuge, When extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is The medicinal liquid of 1.05～1.10, will concentrate after concentrated solution spray dryer be dried, be ground into subsequently 100～ 200 mesh, it is thus achieved that dry powder；

Second step, by Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Herba Orchidis Latifoliae and Cissus pteroclada Hayata in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed surplus stock medical material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter, filtrate Merging, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, in 55 DEG C～ 65 DEG C of reduced vacuum are dried, and obtain dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～5 Times water dissolution, with 40% sodium hydroxide solution regulate pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 35～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3%, parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

7. the preparation method of the Chinese medicine described in a Claims 1-4, it is characterised in that described Chinese medicine Dosage form be granule, it comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 5～the alcohol of 6 times Concentration is the ethanol of 80%～95%, is heated to boiling reflux 4～6 hours, filters, is molten with backflow Agent, with filtering residue as solute, uses percolation with the speed slowly percolation of per minute 1～2ml, collects percolation Liquid, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa, relative density is The mastic of 1.05～1.10, is spray-dried, and the inlet temperature 160 of spray dryer～175 DEG C, goes out pathogenic wind-warm Spend 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

8. the preparation method of the Chinese medicine described in a Claims 1-4, it is characterised in that described Chinese medicine Dosage form be syrup, its preparation method comprises the following steps:

The first step, is mixed red to Lignum Poria, black breast mushroom, lancing, variable color Russula and Radix Rauvolfiae in described ratio Close, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heating and refluxing extraction 2～ 4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, it is centrifuged remove impurity with tube centrifuge, When extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is The medicinal liquid of 1.05～1.10, will concentrate after concentrated solution spray dryer be dried, be ground into subsequently 100～ 200 mesh, it is thus achieved that dry powder；

Second step, by Folium Apocyni Veneti, Pedicularis rex C. B. Clarke ex Maxim., Cladonia alpestris (L.) Rabenh., Herba Orchidis Latifoliae and Cissus pteroclada Hayata in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed surplus stock medical material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter, filtrate Merging, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, in 55 DEG C～ 65 DEG C of reduced vacuum are dried, and obtain dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～5 Times water dissolution, with 40% sodium hydroxide solution regulate pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 35～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3%, parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.