CN105943770A - Traditional Chinese medicine composition for treating breast cancers and hyperplasia of mammary glands and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating breast cancers and hyperplasia of mammary glands and preparation method thereof Download PDFInfo
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- CN105943770A CN105943770A CN201610458098.4A CN201610458098A CN105943770A CN 105943770 A CN105943770 A CN 105943770A CN 201610458098 A CN201610458098 A CN 201610458098A CN 105943770 A CN105943770 A CN 105943770A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention relates to a traditional Chinese medicine composition for treating breast cancers and hyperplasia of mammary glands and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-35 parts of Gansui root, 5-15 parts of Jackinthepulpit tuber, 25-35 parts of raw pinellia tuber, 25-35 parts of root of catclaw buttercup, 7-17 parts of white silkworm, 10-20 parts of white mustard seed, 10-20 parts of gamboge, 16-26 parts of mirabilite, 7-17 parts of Chinese ephedra and 7-17 parts of Peking euphorbia root. The traditional Chinese medicine composition is suitable for breast cancers, hyperplasia of mammary glands, lymph nodules, uterine fibroids, oophoroma and outside scars.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating breast carcinoma, cyclomastopathy and preparation method thereof, belong to
In field of traditional Chinese medicine pharmacy.
Background technology
Female mammary gland is made up of skin, fibrous tissue, corpus mamma and fat, and breast carcinoma is to occur
In the malignant tumor of mammary gland glandular epithelium tissue, mammary gland is not the vitals maintaining human life activity,
Breast cancer in situ is the most fatal；But owing to breast cancer cell loses Normocellular characteristic, between cell
Connect loose, easily come off.Cancerous cell once comes off, and free cancerous cell can be with blood or lymph fluid
Send out whole body, form transfer, threat to life.It is able-bodied often that current breast carcinoma has become threat women
See tumor.
Cyclomastopathy refers to that breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and breast lobule are in structure
On degeneration and the growth of Progressive symmetric erythrokeratodermia connective tissue.
Doctor trained in Western medicine is for treatment cyclomastopathy and the method for breast carcinoma: for the treatment side that local patholoic change person is best
Method, i.e. only by local bulk lesion resection, does not the most also accomplish that all of patient with breast cancer can be carried out
Breast-consering surgery.Also need to the patient with breast cancer being not suitable for Breast-consering surgery excise breast, this operation of doctor trained in Western medicine
Cutting method is treated, and is easily generated sequela, and risk is big, costly.
Summary of the invention
The technical problem to be solved is to provide a kind of Chinese drug-treated group treating breast carcinoma, cyclomastopathy
Compound and preparation method thereof, this Chinese medicine composition disappears karyolymph for a kind of external, it is adaptable to breast carcinoma, mammary gland
Hypertrophy, lymph tuberosity, hysteromyoma, oophoroma and appearance cicatrix.
The technical scheme is that one treats breast carcinoma, cyclomastopathy
Chinese medicine composition, be made up of the raw material of following weight portion:
Radix Kansui 25-35 part, Rhizoma Arisaematis 5-15 part, Rhizoma Pinelliae 25-35 part, Radix Ranunculi Ternati 25-35 part,
Bombyx Batryticatus 7-17 part, Semen Sinapis Albae 10-20 part, Resina garciniae 10-20 part, Mirabilitum 16-26 part, Herba Ephedrae 7-17
Part, Radix Euphorbiae Pekinensis 7-17 part.
On the basis of technique scheme, the present invention can also do following improvement.
Further, described Chinese medicine composition, it is made up of following raw material:
Radix Kansui 30g, Rhizoma Arisaematis 10g, Rhizoma Pinelliae 30g, Radix Ranunculi Ternati 30g, Bombyx Batryticatus 12g, Semen Sinapis Albae 15g,
Resina garciniae 15g, Mirabilitum 21g, Herba Ephedrae 12g, Radix Euphorbiae Pekinensis 12g.
The present invention also provides for the preparation side of the Chinese medicine composition of a kind of above-mentioned treatment breast carcinoma, cyclomastopathy
Method, including:
1) by Radix Kansui, Rhizoma Arisaematis, Rhizoma Pinelliae, Radix Ranunculi Ternati, Bombyx Batryticatus, Semen Sinapis Albae, Resina garciniae, Mirabilitum,
Herba Ephedrae and Radix Euphorbiae Pekinensis mix homogeneously, obtain mixture；
2) at 25-30 DEG C, 7-10 is soaked with the ethanol of mass concentration 95% after mixture is ground into 80 mesh
My god, after adding the normal saline dilution of mass concentration 0.9%, carry out leaching, filter, filtrate
Make liquid dosage form according to this area routine techniques, to obtain final product.
On the basis of technique scheme, the present invention can also do following improvement.
Further, 2) in, the addition of the ethanol of described mass concentration 95% is mixture quality
12.5 times.
Further, 2) in, the addition volume of the normal saline of described mass concentration 0.9% is that quality is dense
3 times of the alcohol by volume of degree 95%.
Theory of Chinese medical science is thought, medicine has the speciality of individual character, side to have gregarious magical effect, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, multi-flavor medicine
Material compatibility uses, and promotes drug effect, reduces toxic and side effects.The present inventor, through anti-screening study, analyzes ratio
Relatively, and face observation through substantial amounts of, finally determine this prescription.The pharmacology of each crude drug in the present invention
Act on as follows:
Radix Kansui: removing water retention by purgation by swollen, dispersing swelling and dissipating binds.
Rhizoma Arisaematis: have scattered wind, eliminate the phlegm, relieving convulsion, effect of pain relieving, can control apoplexy paralysis, brothers' convulsion
Contraction, the diseases such as dizziness, infantile convulsion abundant expectoration of having a headache.
Rhizoma Pinelliae: effect is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, for abundant expectoration cough with asthma, phlegm retention
The headache of vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm, vomiting regurgitation, vexed, the globus hystericus of breast gastral cavity painful abdominal mass etc..Raw using can external treatment
Carbuncle sucutaneous nodule.
Radix Ranunculi Ternati: control pulmonary tuberculosis, malaria, scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria,
Toothache.Tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.
Bombyx Batryticatus: endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses.
Semen Sinapis Albae: reduce phlegm by drink；Mass dissipating and swelling eliminating.Main cough with asthma abundant expectoration；Fullness in the chest and hypochondriac pain；Numb limbs and tense tendons；Close
Joint swells and ache；Multiple abscess caused by damp-phlegm；Carbuncle of yin nature toxic swelling.Control acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma,
Fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain is numb, tinea pedis, carbuncle of yin nature, toxic swelling,
Treating swelling and pain by traumatic injury.
Resina garciniae: for swollen ulcer drug, ulcer, eczema, tumor, stubborn dermatitis, treating swelling and pain by traumatic injury, skin ulcer wound is hemorrhage
And scald.
Mirabilitum: stagnating for excess-heat, abdominal distention distending pain, constipation due to dry stool, acute appendicitis swells and ache；External treatment acute mastitis, hemorrhoid
Skin ulcer swells and ache.
Herba Ephedrae: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.
The Radix Euphorbiae Pekinensis: removing water retention by purgation Shen, profit two is just.Harness the river swollen, dropsy, phlegm retention, scrofula, swollen ulcer drug.
The invention has the beneficial effects as follows:
Chinese medicine composition of the present invention by Chinese herbal medicine extraction dilution after use, it is adaptable to breast carcinoma, cyclomastopathy,
Lymph tuberosity, hysteromyoma, oophoroma and appearance cicatrix, can be applied in during use or be sprayed on affected part.
Once a day, 3-5 days take effect, and within the basic 1-2 of lump of 30*30mm month, can melt.
Although Rhizoma Pinelliae and Rhizoma Arisaematis are poisonous in the present invention, but the use that this dosage form is medicine for external use and each medical material
Measure and obtain through inventor's reasonable compatibility and a large amount of screening, therefore be safe medication.
Detailed description of the invention
Principle and feature to the present invention are described below, and example is served only for explaining the present invention, and
Non-for limiting the scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition treating breast carcinoma, cyclomastopathy, is made up of following raw material:
Radix Kansui 30g, Rhizoma Arisaematis 10g, Rhizoma Pinelliae 30g, Radix Ranunculi Ternati 30g, Bombyx Batryticatus 12g, Semen Sinapis Albae 15g,
Resina garciniae 15g, Mirabilitum 21g, Herba Ephedrae 12g, Radix Euphorbiae Pekinensis 12g.
Preparation method:
1) by Radix Kansui, Rhizoma Arisaematis, Rhizoma Pinelliae, Radix Ranunculi Ternati, Bombyx Batryticatus, Semen Sinapis Albae, Resina garciniae, Mirabilitum,
Herba Ephedrae and Radix Euphorbiae Pekinensis mix homogeneously, obtain mixture；
2) at 25-30 DEG C, 7-10 is soaked with the ethanol of mass concentration 95% after mixture is ground into 80 mesh
My god, addition is mixture quality 12.5 times of the ethanol of described mass concentration 95%, add quality
After the normal saline dilution of concentration 0.9%, the addition volume of the normal saline of described mass concentration 0.9% is
3 times of the alcohol by volume of mass concentration 95%, carry out leaching, filter, and filtrate is normal according to this area
Rule technology makes water tincture mixing liquid dosage form, smears use, specification 30ml/ bottle.
Model case:
Patient Zhao so-and-so, female, 53 years old, within 2012, be diagnosed as breast carcinoma, go around various big hospital and all build
View is performed the operation immediately.In August, 2014, I went out diagnosis and treatment, smeared or spray the breast of the embodiment of the present invention 1 preparation
The gland hypertrophy karyolymph that disappears, in affected part, every day 1 time, is smeared 8ml every time, is applied in affected part, smear 1 month
After, the state of an illness is clearly better, and affected area occurs in that calcified plaque, after smearing 12 months, and breast tumor
Basic disappearance.
Patient Lee so-and-so, female, 51 years old, within 2011, be diagnosed as cyclomastopathy, hysteromyoma, hospital
Advise excision hysteromyoma immediately.In January, 2015 here diagnosis and treatment, smear or spray the present invention in fact
Execute example 1 preparation the karyolymph that disappears in affected part, every day 1 time, smear 15ml every time, be applied in affected part, smear
After 1 month, cyclomastopathy is almost recovered, and the hysteromyoma state of an illness is clearly better, after smearing 6 months
Hysteromyoma is obviously reduced, and after smearing 8 months, uterus tumor disappears substantially.
Patient Zhang, female, 51 years old, within 2011, it is diagnosed as cyclomastopathy, hysteromyoma, hospital
Advise excision hysteromyoma immediately.In February, 2015 here diagnosis and treatment, smear or spray the present invention in fact
Execute example 1 preparation the karyolymph that disappears in affected part, every day 1 time, smear 15ml every time, be applied in affected part, smear
After 15 days, cyclomastopathy is almost recovered, and the hysteromyoma state of an illness is clearly better, son after smearing 5 months
Palace muscular tumor is obviously reduced, and after smearing 8 months, uterus tumor disappears substantially.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all in the present invention
Spirit and principle within, any modification, equivalent substitution and improvement etc. made, should be included in this
Within bright protection domain.
Claims (5)
1. the Chinese medicine composition treating breast carcinoma, cyclomastopathy, it is characterised in that by weighing as follows
The raw material composition of amount part:
Radix Kansui 25-35 part, Rhizoma Arisaematis 5-15 part, Rhizoma Pinelliae 25-35 part, Radix Ranunculi Ternati 25-35 part,
Bombyx Batryticatus 7-17 part, Semen Sinapis Albae 10-20 part, Resina garciniae 10-20 part, Mirabilitum 16-26 part, Herba Ephedrae 7-17
Part, Radix Euphorbiae Pekinensis 7-17 part.
Chinese medicine composition the most according to claim 1, it is characterised in that be made up of following raw material:
Radix Kansui 30g, Rhizoma Arisaematis 10g, Rhizoma Pinelliae 30g, Radix Ranunculi Ternati 30g, Bombyx Batryticatus 12g, Semen Sinapis Albae 15g,
Resina garciniae 15g, Mirabilitum 21g, Herba Ephedrae 12g, Radix Euphorbiae Pekinensis 12g.
3. a preparation method for the Chinese medicine composition as described in claim 1-2 is arbitrary, its feature exists
In, including:
1) by Radix Kansui, Rhizoma Arisaematis, Rhizoma Pinelliae, Radix Ranunculi Ternati, Bombyx Batryticatus, Semen Sinapis Albae, Resina garciniae, Mirabilitum,
Herba Ephedrae and Radix Euphorbiae Pekinensis mix homogeneously, obtain mixture；
2) at 25-30 DEG C, 7-10 is soaked with the ethanol of mass concentration 95% after mixture is ground into 80 mesh
My god, after adding the normal saline dilution of mass concentration 0.9%, carry out leaching, filter, filtrate
Make liquid dosage form according to this area routine techniques, to obtain final product.
Preparation method the most according to claim 3, it is characterised in that 2) in, described quality
The addition of the ethanol of concentration 95% is 12.5 times of mixture quality.
Preparation method the most according to claim 3, it is characterised in that 2) in, described quality
3 times that add the alcohol by volume that volume is mass concentration 95% of the normal saline of concentration 0.9%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610458098.4A CN105943770A (en) | 2016-06-22 | 2016-06-22 | Traditional Chinese medicine composition for treating breast cancers and hyperplasia of mammary glands and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610458098.4A CN105943770A (en) | 2016-06-22 | 2016-06-22 | Traditional Chinese medicine composition for treating breast cancers and hyperplasia of mammary glands and preparation method thereof |
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| CN105943770A true CN105943770A (en) | 2016-09-21 |
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| CN201610458098.4A Pending CN105943770A (en) | 2016-06-22 | 2016-06-22 | Traditional Chinese medicine composition for treating breast cancers and hyperplasia of mammary glands and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224042A (en) * | 2018-09-03 | 2019-01-18 | 张董晓 | A kind of Chinese medicine composition and its preparation for treating cyclomastopathy |
| CN109985208A (en) * | 2019-03-28 | 2019-07-09 | 付艳霞 | A kind of Chinese medicine composition for the ruffian patch that disappears |
| CN115590914A (en) * | 2022-09-29 | 2023-01-13 | 云南中医药大学（Cn） | Knoxia extract and application thereof in preparation of anti-breast cancer drugs |
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| CN101185711A (en) * | 2006-11-15 | 2008-05-28 | 杨恩铭 | Nucleus eliminating ointment special for treating hyperplasia of mammary glands |
| CN103230555A (en) * | 2013-04-23 | 2013-08-07 | 山西丰源药业有限公司 | External medicine for treating hyperplasia of mammary glands and preparation method thereof |
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2016
- 2016-06-22 CN CN201610458098.4A patent/CN105943770A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185711A (en) * | 2006-11-15 | 2008-05-28 | 杨恩铭 | Nucleus eliminating ointment special for treating hyperplasia of mammary glands |
| CN103230555A (en) * | 2013-04-23 | 2013-08-07 | 山西丰源药业有限公司 | External medicine for treating hyperplasia of mammary glands and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224042A (en) * | 2018-09-03 | 2019-01-18 | 张董晓 | A kind of Chinese medicine composition and its preparation for treating cyclomastopathy |
| CN109985208A (en) * | 2019-03-28 | 2019-07-09 | 付艳霞 | A kind of Chinese medicine composition for the ruffian patch that disappears |
| CN109985208B (en) * | 2019-03-28 | 2022-01-28 | 付艳霞 | Traditional Chinese medicine composition of lump relieving plaster |
| CN115590914A (en) * | 2022-09-29 | 2023-01-13 | 云南中医药大学（Cn） | Knoxia extract and application thereof in preparation of anti-breast cancer drugs |
| CN115590914B (en) * | 2022-09-29 | 2023-11-24 | 云南中医药大学 | Euphorbia pekinensis extract and application thereof in preparation of breast cancer resisting medicines |
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