CN105940004B - 化合物 - Google Patents
化合物 Download PDFInfo
- Publication number
- CN105940004B CN105940004B CN201580006361.XA CN201580006361A CN105940004B CN 105940004 B CN105940004 B CN 105940004B CN 201580006361 A CN201580006361 A CN 201580006361A CN 105940004 B CN105940004 B CN 105940004B
- Authority
- CN
- China
- Prior art keywords
- mmol
- pharmaceutically acceptable
- methyl
- compound
- lcms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC*c1c(C=C*2)c2nc(Nc(cn[n]2[C@](CCN(C3)C4COC4)C3(F)F)c2Cl)n1 Chemical compound CC*c1c(C=C*2)c2nc(Nc(cn[n]2[C@](CCN(C3)C4COC4)C3(F)F)c2Cl)n1 0.000 description 17
- IPRDJWPLOVTMQT-UHFFFAOYSA-N CC(C(CCNC1COCC1)N1NCCC(N)=C1C)F Chemical compound CC(C(CCNC1COCC1)N1NCCC(N)=C1C)F IPRDJWPLOVTMQT-UHFFFAOYSA-N 0.000 description 1
- MNCFCPKTMZCGQD-UHFFFAOYSA-N CC(C(F)F)C1OCCNC1 Chemical compound CC(C(F)F)C1OCCNC1 MNCFCPKTMZCGQD-UHFFFAOYSA-N 0.000 description 1
- CQJNLLKOOKTIJB-DTIOYNMSSA-N CC(C)(C)OC(N(CC(C1)[n]2ncc(N=O)c2)C[C@H]1O)=O Chemical compound CC(C)(C)OC(N(CC(C1)[n]2ncc(N=O)c2)C[C@H]1O)=O CQJNLLKOOKTIJB-DTIOYNMSSA-N 0.000 description 1
- YGIPIARFNXHZEM-UHFFFAOYSA-N CC(C)(C[n]1nc(C)c([N+]([O-])=O)c1C)O Chemical compound CC(C)(C[n]1nc(C)c([N+]([O-])=O)c1C)O YGIPIARFNXHZEM-UHFFFAOYSA-N 0.000 description 1
- KPZTVIDCWKUBPC-UHFFFAOYSA-N CC(CCC1)(C1[n]1ncc(N)c1C)O Chemical compound CC(CCC1)(C1[n]1ncc(N)c1C)O KPZTVIDCWKUBPC-UHFFFAOYSA-N 0.000 description 1
- HCJKSBDGCHXLLG-XZMRHVKESA-N CC/C(/C=N)=C(\C)/NC(CCN(C1)C2COC2)C1(F)F Chemical compound CC/C(/C=N)=C(\C)/NC(CCN(C1)C2COC2)C1(F)F HCJKSBDGCHXLLG-XZMRHVKESA-N 0.000 description 1
- OLXDFVIQVISYRX-YSZBQJHXSA-N CCOc1c(cc[nH]2)c2nc(NC(C=N[C@@](C)(C2)[C@](C)(CCN(C3)C4COC4)[C@@H]3F)=C2Cl)n1 Chemical compound CCOc1c(cc[nH]2)c2nc(NC(C=N[C@@](C)(C2)[C@](C)(CCN(C3)C4COC4)[C@@H]3F)=C2Cl)n1 OLXDFVIQVISYRX-YSZBQJHXSA-N 0.000 description 1
- YTEPHMOFURICDX-UKRRQHHQSA-N CCOc1c(cc[nH]2)c2nc(Nc(cn[n]2[C@H](CCN(C3)C4COC4)[C@@H]3F)c2Cl)n1 Chemical compound CCOc1c(cc[nH]2)c2nc(Nc(cn[n]2[C@H](CCN(C3)C4COC4)[C@@H]3F)c2Cl)n1 YTEPHMOFURICDX-UKRRQHHQSA-N 0.000 description 1
- NZKXGGUFPRUXLE-UHFFFAOYSA-N CCOc1c(cc[nH]2)c2nc(Nc2c(C)[n](CC(C)(C)O)nc2)n1 Chemical compound CCOc1c(cc[nH]2)c2nc(Nc2c(C)[n](CC(C)(C)O)nc2)n1 NZKXGGUFPRUXLE-UHFFFAOYSA-N 0.000 description 1
- ZLTIWEDENJXTHK-GNRKCLAOSA-N CN(CCC1N/C=C(\C=N)/[N+]([O-])=O)CC1(F)F Chemical compound CN(CCC1N/C=C(\C=N)/[N+]([O-])=O)CC1(F)F ZLTIWEDENJXTHK-GNRKCLAOSA-N 0.000 description 1
- MOSFWXHLYZHBGC-SNVBAGLBSA-N C[C@H]1N(CC[n]2ncc(OC)c2C)CCOC1 Chemical compound C[C@H]1N(CC[n]2ncc(OC)c2C)CCOC1 MOSFWXHLYZHBGC-SNVBAGLBSA-N 0.000 description 1
- VQRDCJAPAZJUMN-UHFFFAOYSA-N Cc([n](C(CCC1)C1O)nc1)c1[N+]([O-])=O Chemical compound Cc([n](C(CCC1)C1O)nc1)c1[N+]([O-])=O VQRDCJAPAZJUMN-UHFFFAOYSA-N 0.000 description 1
- BPZYLTBLBSNUNY-BYPYZUCNSA-N FC([C@H]1OCCNC1)F Chemical compound FC([C@H]1OCCNC1)F BPZYLTBLBSNUNY-BYPYZUCNSA-N 0.000 description 1
- BNPOEVOYZGKURM-UHFFFAOYSA-N O=Nc1c(C2CC2)[n](C2CCOCC2)nc1 Chemical compound O=Nc1c(C2CC2)[n](C2CCOCC2)nc1 BNPOEVOYZGKURM-UHFFFAOYSA-N 0.000 description 1
- JHBIUGWXJOTGAV-ZETCQYMHSA-N [O-][N+](c1c[n]([C@@H]2CNCCC2)nc1)=O Chemical compound [O-][N+](c1c[n]([C@@H]2CNCCC2)nc1)=O JHBIUGWXJOTGAV-ZETCQYMHSA-N 0.000 description 1
- IHXWAAFYDDYHFU-SSDOTTSWSA-N [O-][N+](c1c[n]([C@H]2C[N-]CCC2)nc1)=O Chemical compound [O-][N+](c1c[n]([C@H]2C[N-]CCC2)nc1)=O IHXWAAFYDDYHFU-SSDOTTSWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/000139 | 2014-01-29 | ||
| CN2014000139 | 2014-01-29 | ||
| PCT/CN2015/000055 WO2015113452A1 (en) | 2014-01-29 | 2015-01-28 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105940004A CN105940004A (zh) | 2016-09-14 |
| CN105940004B true CN105940004B (zh) | 2018-02-02 |
Family
ID=53756224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580006361.XA Expired - Fee Related CN105940004B (zh) | 2014-01-29 | 2015-01-28 | 化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10087186B2 (https=) |
| EP (1) | EP3099695B1 (https=) |
| JP (1) | JP6422986B2 (https=) |
| KR (1) | KR20160106622A (https=) |
| CN (1) | CN105940004B (https=) |
| AU (2) | AU2015210593A1 (https=) |
| CA (1) | CA2937431A1 (https=) |
| CL (1) | CL2016001895A1 (https=) |
| CR (1) | CR20160348A (https=) |
| DO (2) | DOP2016000195A (https=) |
| EA (1) | EA029774B1 (https=) |
| ES (1) | ES2802174T3 (https=) |
| IL (1) | IL246579B (https=) |
| MA (1) | MA39219B1 (https=) |
| MX (1) | MX367370B (https=) |
| PE (1) | PE20161443A1 (https=) |
| PH (1) | PH12016501307B1 (https=) |
| SG (1) | SG11201605342UA (https=) |
| UA (1) | UA118369C2 (https=) |
| WO (1) | WO2015113452A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10339791B2 (en) | 2007-06-12 | 2019-07-02 | Icontrol Networks, Inc. | Security network integrated with premise security system |
| KR20160106622A (ko) | 2014-01-29 | 2016-09-12 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화합물 |
| ES2717757T3 (es) | 2014-01-29 | 2019-06-25 | Glaxosmithkline Ip Dev Ltd | Compuestos |
| CN105153131B (zh) * | 2015-09-21 | 2017-10-17 | 马彦丽 | 一种在护理上治疗人神经胶质瘤的药物组合物 |
| CN105348270B (zh) * | 2015-11-09 | 2018-01-09 | 吕显艳 | 一种防治牙体牙髓感染的药物组合物 |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| JP2018537502A (ja) | 2015-12-16 | 2018-12-20 | サウザーン リサーチ インスチチュート | ピロロピリミジン化合物、キナーゼｌｒｒｋ２阻害剤としての使用、及びその調製方法 |
| CN105418616B (zh) * | 2015-12-26 | 2018-01-12 | 山东大学 | 一种含有 4‑氨基吡唑结构的jak 激酶抑制剂及其制备方法和应用 |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| MD3472153T2 (ro) | 2016-06-16 | 2022-03-31 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1H-pirazoli în calitate de inhibitori L RRK2 pentru utilizare în tratamentul tulburărilor neurodegenerative |
| CN110446700A (zh) * | 2017-01-25 | 2019-11-12 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
| KR20180097162A (ko) | 2017-02-22 | 2018-08-30 | 국립암센터 | 피롤로-피리미딘 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101896568B1 (ko) * | 2017-03-23 | 2018-09-10 | 재단법인 대구경북첨단의료산업진흥재단 | 피롤로-피리딘 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물 |
| SG11202005264PA (en) * | 2017-12-05 | 2020-07-29 | Oscotec Inc | Pyrrolo(pyrazolo)pyrimidine derivative as lrrk2 inhibitor |
| CN108715834B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种富含cd41+、cd81+微囊的血小板裂解液制备方法 |
| WO2020036437A1 (ko) * | 2018-08-16 | 2020-02-20 | 재단법인 대구경북첨단의료산업진흥재단 | 치환된 헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물 |
| IL281765B2 (en) * | 2018-09-25 | 2024-04-01 | Cardurion Pharmaceuticals Inc | Aminopyrimidine compound |
| US12240844B2 (en) | 2019-01-18 | 2025-03-04 | Voronoi, Inc. | Pyrrolopyridine derivative and use thereof in prevention and treatment of protein kinase-related disease |
| CZ308800B6 (cs) | 2019-02-12 | 2021-05-26 | Univerzita Palackého v Olomouci | Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci |
| EP4236950A4 (en) | 2020-10-29 | 2024-10-23 | Merck Sharp & Dohme LLC | N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| CN114426542B (zh) * | 2020-10-29 | 2023-06-30 | 苏州亚宝药物研发有限公司 | 取代的二芳基胺化合物及其药物组合物、制备方法和用途 |
| KR20220081631A (ko) | 2020-12-09 | 2022-06-16 | 보로노이 주식회사 | 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도 |
| JP2024541934A (ja) | 2021-10-27 | 2024-11-13 | ハー・ルンドベック・アクチエゼルスカベット | Ｌｒｒｋ２阻害剤 |
| WO2023076404A1 (en) | 2021-10-27 | 2023-05-04 | Aria Pharmaceuticals, Inc. | Methods for treating systemic lupus erythematosus |
| AR130483A1 (es) | 2022-09-15 | 2024-12-11 | H Lundbeck As | Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2) |
Citations (6)
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| WO2011038572A1 (en) * | 2009-09-29 | 2011-04-07 | Glaxo Group Limited | Novel compounds |
| WO2012062783A1 (en) * | 2010-11-10 | 2012-05-18 | F. Hoffmann-La Roche Ag | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
| WO2013079496A1 (en) * | 2011-11-30 | 2013-06-06 | F. Hoffmann-La Roche Ag | Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (pet) imaging for lrrk2 |
| WO2013139882A1 (en) * | 2012-03-21 | 2013-09-26 | F. Hoffmann-La Roche Ag | Pyrazolopyridines for treatment of parkinsons disease |
| CN103492389A (zh) * | 2011-04-21 | 2014-01-01 | 原真股份有限公司 | 用作激酶抑制剂的吡唑并[4,3-d]嘧啶 |
| WO2014001973A1 (en) * | 2012-06-29 | 2014-01-03 | Pfizer Inc. | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS |
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| WO2005028480A2 (en) | 2003-09-03 | 2005-03-31 | Neurogen Corporation | 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| WO2006045392A2 (en) | 2004-10-21 | 2006-05-04 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Kaspp (lrrke) gene, its production and use for the detection and treatment of neurodegenerative disorders |
| US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| NO323175B1 (no) | 2004-12-23 | 2007-01-15 | Jan O Aasly | Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme |
| WO2007042298A1 (en) | 2005-10-13 | 2007-04-19 | Glaxo Group Limited | Pyrrolopyrimidine derivatives as syk inhibitors |
| CA2651072A1 (en) | 2006-05-01 | 2007-11-08 | Pfizer Products Inc. | Substituted 2-amino-fused heterocyclic compounds |
| WO2009036066A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Vegfr inhibitors containing a zinc binding moiety |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2009143404A1 (en) | 2008-05-23 | 2009-11-26 | Wyeth | Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression |
| KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Ｅｇｆｒ 억제제 및 질환 치료방법 |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| WO2012009258A2 (en) | 2010-07-13 | 2012-01-19 | Edward Roberts | Peptidomimetic galanin receptor modulators |
| WO2012045195A1 (en) | 2010-10-09 | 2012-04-12 | Abbott Laboratories | Pyrrolopyrimidines as fak and alk inhibiters for treatment of cancers and other diseases |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| EP2651405A2 (en) | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| KR20140059246A (ko) | 2011-09-22 | 2014-05-15 | 화이자 인코포레이티드 | 피롤로피리미딘 및 퓨린 유도체 |
| RU2637947C2 (ru) | 2012-05-03 | 2017-12-08 | Дженентек, Инк. | Производные пиразоламинопиримидина в качестве модуляторов обогащенной лейциновыми повторами киназы 2 |
| CN106279202A (zh) | 2012-05-03 | 2017-01-04 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂用于治疗帕金森病的吡唑氨基嘧啶衍生物 |
| KR20160106622A (ko) | 2014-01-29 | 2016-09-12 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화합물 |
| ES2717757T3 (es) | 2014-01-29 | 2019-06-25 | Glaxosmithkline Ip Dev Ltd | Compuestos |
-
2015
- 2015-01-28 KR KR1020167020367A patent/KR20160106622A/ko not_active Ceased
- 2015-01-28 US US15/114,858 patent/US10087186B2/en not_active Expired - Fee Related
- 2015-01-28 MX MX2016009893A patent/MX367370B/es active IP Right Grant
- 2015-01-28 WO PCT/CN2015/000055 patent/WO2015113452A1/en not_active Ceased
- 2015-01-28 UA UAA201609099A patent/UA118369C2/uk unknown
- 2015-01-28 CA CA2937431A patent/CA2937431A1/en not_active Abandoned
- 2015-01-28 PE PE2016001250A patent/PE20161443A1/es unknown
- 2015-01-28 EP EP15743797.1A patent/EP3099695B1/en active Active
- 2015-01-28 CN CN201580006361.XA patent/CN105940004B/zh not_active Expired - Fee Related
- 2015-01-28 CR CR20160348A patent/CR20160348A/es unknown
- 2015-01-28 ES ES15743797T patent/ES2802174T3/es active Active
- 2015-01-28 AU AU2015210593A patent/AU2015210593A1/en not_active Abandoned
- 2015-01-28 MA MA39219A patent/MA39219B1/fr unknown
- 2015-01-28 SG SG11201605342UA patent/SG11201605342UA/en unknown
- 2015-01-28 JP JP2016549028A patent/JP6422986B2/ja not_active Expired - Fee Related
- 2015-01-28 EA EA201691514A patent/EA029774B1/ru not_active IP Right Cessation
-
2016
- 2016-06-30 PH PH12016501307A patent/PH12016501307B1/en unknown
- 2016-07-03 IL IL246579A patent/IL246579B/en not_active IP Right Cessation
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2018
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| WO2011038572A1 (en) * | 2009-09-29 | 2011-04-07 | Glaxo Group Limited | Novel compounds |
| WO2012062783A1 (en) * | 2010-11-10 | 2012-05-18 | F. Hoffmann-La Roche Ag | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
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