CN105930617A - Method for designing and forming stiffness-controllable bone tumor defect repair implant - Google Patents
Method for designing and forming stiffness-controllable bone tumor defect repair implant Download PDFInfo
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- CN105930617A CN105930617A CN201610324400.7A CN201610324400A CN105930617A CN 105930617 A CN105930617 A CN 105930617A CN 201610324400 A CN201610324400 A CN 201610324400A CN 105930617 A CN105930617 A CN 105930617A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F30/00—Computer-aided design [CAD]
- G06F30/20—Design optimisation, verification or simulation
- G06F30/23—Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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Abstract
The invention discloses a method for designing and forming a stiffness-controllable bone tumor defect repair implant. The method comprises the following steps of acquiring and preprocessing image data; performing reverse image fusion and registration, and constructing an accurate curve surface materialized repair body model; carrying out parallel finite element analysis and optimization on a porous design scheme by a microscopic porous scheme design; and importing the model into a 3D printing system for printing forming. According to the method, a personalized porous structure, mechanical optimization design and 3D printing forming of a post-bone tumor excision defect area reconstruction repair body are realized in combination with digital modeling, finite element analysis and medical 3D printing technologies according to a symmetric characteristic of a human body structure morphology, so that the reconstruction effect of an individualized anatomic morphology and the design forming efficiency of the repair body are improved, the time and material costs are reduced, the mechanical properties and the bone integration microenvironment after reconstruction are better optimized, and the bone growth repair of a bone defect area is facilitated.
Description
Technical field
The present invention relates to the controlled bone tumour defect repair implant design of a kind of rigidity and shaping
Method.
Background technology
After bone tumour resection, the Anatomical Reconstruction that becomes more meticulous of Cranial defect is always a medical circle difficult problem, autologous
Bone grafting is ideal material and the method for reconstruction Cranial defect, but there is increase operation wound, takes
The complication of bony site is as infected and pain, and the taken amount that there is autologous bone is limited, it is difficult to full
The shortcomings such as the requirement of the big section bone collection of foot.And traditional prosthesis because of self standardization, mass,
Serializing produces and differs greatly with patient anatomical's parameter and internal individualized feature and cannot meet
The reconstruction requirement of its dissimilar defect so that prosthese is difficult to the interaction of surrounding tissue
Optimize, finally because of prosthese rebuild do not mate, fatigue failure causes dysfunction, repairing failure.
Therefore, the personalized designs of bone tumour resection postoperative bone defect healing prosthese be medical development must
So trend.
At present, it mostly is surface finish structure outside tumorous type prosthese used clinically, unfavorable
Growing in surrounding tissue and affect Integrated implant, passage is it would appear that prosthetic loosening over time.And
There is scholar to propose at prosthese and fill bone cement with bone tissue junction, but this method is unfavorable for
Later stage prosthese takes out and overhauls；Another have porous design to implant prosthese on the market, though having built favourable
Integrated implant microenvironment, but to be difficult to meet patient dissimilar because of its standard normalized batch production
The reconstruction requirement of defect, and it is easily caused a large amount of bone loss.And most metals implants vacation at present
Body rigidity is all far longer than the elastic modelling quantity of body bone tissue, easily causes stress-shielding effect to lead
Cause prosthese fatigue fracture, though and biomaterial such as hydroxyapatite matter, calcium sulfate have excellent
Biocompatibility and the high-affinity with protein molecule, but its quality is crisp, poor toughness, strong
Spending low, flexural strength and fracture toughness index are all difficult to meet mechanical stability demand.
Therefore, need to consider to repair implant in the postoperative bone defect healing of bone tumour resection is rebuild
The problems such as anatomical compatibility, biocompatibility, osteoinductive and mechanical stability, in order to more
Solve well the problems referred to above, introduce Individual Digital design, finite element analysis and 3D and be printed as
Type technology designs with the optimization of auxiliary porous structure implant has important clinical significance.
Summary of the invention
The bone tumour defect repair implant that the present invention provides a kind of rigidity controlled designs and shaping
Method can according to organization of human body form symmetry characteristic, in conjunction with digital modeling, finite element analysis and
Medical science 3D printing technique, it is achieved the postoperative defective region of bone tumour resection rebuilds the personalization of dummy
The design of loose structure, mechanics optimization and 3D printing shaping, not only increase individuation and dissect shape
The reconstruction effect of state and the design shaping efficiency of dummy, reduce time and material cost, more excellent
Change the mechanical characteristic after rebuilding and Integrated implant microenvironment, the beneficially bone uptake in Cranial defect district have been repaiied
Multiple.
For solving the problems referred to above, the present invention adopts the following technical scheme that
A kind of rigidity controlled bone tumour defect repair implant design and forming method, including such as
Lower step:
1) image acquisitions and pretreatment: Ipsilateral and corresponding strong side are carried out standard CT/MR
Scanning, obtains target site original fault image Dicom formatted data and uses median filtering method
Eliminate impulsive noise and salt-pepper noise, then ask second order to lead with Gauss-Laplace conversion denoising
Vowing, the zero crossing led with second order determines and protects signal edge；
2) Ipsilateral tumor resection is postoperative and mirror image defect repair is rebuild with reference to three-dimensional digital model,
Pretreated Dicom data are imported medical science modeling software, determines pixel by Threshold segmentation
Intensity value ranges, utilizes region to increase and separates the discrete voxel of removal, Interactive Segmentation low resolution
Image determines target area border, in conjunction with ablation, expands and smooths morphological operation and finally obtain
Ipsilateral and corresponding strong side object construction precisely emulate three-dimensional digital model, by strong side object construction
It is copied to Ipsilateral by emulation module sagittal plane image feature, generates the three-dimensional that defect area is repaired
Mathematical model, further according to the good osteotomy programme of Design at Ipsilateral virtual osteotomy to obtain
Bone tumour resection postoperative bony structure model, exports as STL form by model；
3) bone defect healing body Model reverse-engineers and hypostazation: by step 2) the middle STL obtained
Model file imports reverse engineering software further, according to the reference point registered before by bone tumour
After resection, model and mirror image defect repair reference model carry out preliminary images registration, in conjunction with inverse
Three-dimension space image in engineering software merges registration function, analysis and solution two model maximum weight
Stack is amassed, it is thus achieved that optimum intersection figure registrates, then two models after registration are carried out Boolean calculation and tried to achieve
Bone defect healing body Model, utilizes reverse engineering software polygon functional module by bone defect healing
Body Model is filled with, relaxes, light genial open manifold operation optimization curved surface, then edit outline line,
Constructing curve sheet, the structure final fitting surface of grid generate hypostazation model；
4) design of dummy interior microscopic porous and Finite Element Simulation Analysis: by step 3) in
The bone defect healing body STP model generated imports CAD software, with reference to current standardized porous
Structural design elements, carries out cutting operation by bone defect healing body, and according to implant reparation
Porosity is controlled in certain limit by target area, it is thus achieved that the porous microstructure bone of different shape lacks
Damage dummy model, then the porous dummy model built is imported finite element analysis software, enter
Row material assignment, stress and strain model, boundary condition and load set, the more certain bar of simulation analysis
Under part diverse microcosmic form porous dummy rebuild repairing bone defect time stress, change in displacement,
Solve the loose structure design that individuation stiffness characteristics is optimum；
5) bone tumour resection postoperative defective region porous repairs the 3D printing shaping of implant: select
Rapid shaping technique and moulding material, by step 4) in try to achieve optimum porous design reparation
Body Model imports 3D printing-forming system, on-demand utilize pre-processing software generate corresponding rationally
Support and printing shaping, then be supported removing, print post processing to obtain the bone of stiffness optimization
Tumour defect 3D prints porous and repairs implant.
Further, described step 2) in medical science modeling software be Mimics or
Simpleware or 3D-doctor, modeling process uses the voxel automatically and manually combined to divide
Cut method, reconstruct three-dimensional digital model in conjunction with Interactive Segmentation and ablation, expansion form operation.
Further, described step 3) in image registration at common reverse engineering software
In complete: Geomagic studio or RapidForm or CopyCAD or Imageware.
Further, described step 4) in dummy interior microscopic porous design pass through
Solidworks or Pro-e or UG completes, and Finite Element Simulation Analysis combines Abaqus or Ansys
Or Adina or Msc implements.
Further, described step 5) in moulding material be polyether-ether-ketone or hydroxyapatite
Or calcium sulfate or its thing material or implantable metal material, printing shaping mode is DMLS or SLM
Or take metal/hydroxyapatite to print filling osteogenic induction cell.
The invention have the benefit that by utilizing reconstruction of medical images and 3D to print skill
Art design bone defect healing body, has individuation customization and maximum anatomic form coupling is excellent
Gesture；Rebuild and CAD design in conjunction with digital medical, carry out pre-operative surgical rule the most intuitive and reliablely
Draw, and obtain dummy reference model the most accurately according to this, retain bone amount to greatest extent,
Reduce the incidence of clinical complication；The design of the loose structure related to, for bone-dummy wound
Make the most rational Integrated implant microenvironment, beneficially later stage bone uptake, compare tradition dummy more
Tool biological superiority；By Finite Element Simulation Analysis, the porous microstructure solving stiffness optimization is new
Implant repaired by type, compares tradition dummy more mechanical advantage.
Accompanying drawing explanation
Fig. 1 is the Ipsilateral three-dimensional digital model figure of the present invention.
Fig. 2 is the strong side three-dimensional digital model figure of the present invention.
Fig. 3 is the defect repair reference model figure of the present invention.
Fig. 4 is the implant structure chart of the present invention.
Fig. 5 is the implant body microcosmic loose structure figure of the present invention.
Detailed description of the invention
As Figure 1-Figure 5, the bone tumour defect repair implant design that a kind of rigidity is controlled
And forming method, comprise the steps:
1) image acquisitions and pretreatment: Ipsilateral and corresponding strong side are carried out 64 row's spirals
CT scan, obtains target site original fault image Dicom formatted data automatic numbering row
Sequence, then uses median filtering method to eliminate impulsive noise and salt-pepper noise original CT image,
Then asking second order to lead arrow with Gauss-Laplace conversion denoising, the zero crossing led with second order determines
And protect signal edge, beneficially later image segmentation；
2) Ipsilateral tumor resection is postoperative and mirror image defect repair is rebuild with reference to three-dimensional digital model:
Pretreated Dicom data are imported medical science modeling software Mimics, passes through Threshold segmentation
(Threshold) determine grey scale pixel value scope, utilize region to increase (Region Growing)
Separate and remove discrete voxel, and interactive by 3D Magnetic Lasso function (3D Live Wire)
Segmentation low-resolution image determines target area border, in conjunction with ablation (erode), expands
(dilate) morphological operation such as smooth (smoothing) finally obtains Ipsilateral and corresponding strong
Side object construction precisely emulate three-dimensional digital model；Above-mentioned strong side object construction is passed through
Simulation module image function, by sagittal plane image copying to Ipsilateral, generates mirror image
Defect repair, with reference to three-dimensional digital model, obtains bone further according to preoperative planning at Ipsilateral virtual osteotomy
Tumor resection postoperative bony structure model, registers 2 model reference points respectively, is exported as by model
STL form；
3) bone defect healing body Model reverse-engineers and hypostazation: obtain in above-mentioned steps (2)
STL model file imports reverse engineering software Geomagic further, according to the ginseng registered before
Model after excision of bone tumor and mirror image defect repair reference model are carried out preliminary images by examination point
Registration, carries out three-dimensional graph in conjunction with functions such as the best fit alignment in reverse engineering software
As merging registration, analysis and solution two model Maximum overlap volume, it is thus achieved that optimal spatial registration information,
Again two models after registration are carried out Boolean calculation and try to achieve bone defect healing body Model, utilize reverse
Bone defect healing body Model is filled with, relaxes by engineering software polygon functional module, fairing,
The operation optimization curved surfaces such as open manifold, then edit outline line, constructing curve sheet, structure grid final
Fitting surface generates hypostazation model；
4) design of dummy interior microscopic porous and Finite Element Simulation Analysis: by above-mentioned steps (3)
The bone defect healing body STP model of middle generation imports CAD software, with reference to the most conventional
The design of several loose structures, bone defect healing body is carried out cutting operation, and by porosity control
System is in certain limit, it is thus achieved that the porous microstructure bone defect healing body Model that different shape is out of shape,
Again these several groups of porous dummy models are imported finite element analysis software, carry out material assignment, net
Lattice division, boundary condition and load set, and simulation analysis compares diverse microcosmic shape under certain condition
Stress during state porous dummy reconstruction repairing bone defect, change in displacement, solve individual rigidity special
Property optimum loose structure design；
5) bone tumour resection postoperative defective region porous repairs the 3D printing shaping of implant: select
Suitable rapid shaping technique and moulding material, the optimal porous will tried to achieve in above-mentioned steps (4)
The dummy model of design imports corresponding 3D printing-forming system, on-demand utilizes pre-processing software
Generate the corresponding also printing shaping that rationally supports, then row supports removal etc. and prints post processing acquisition bone
Postoperative personalized porous 3D of tumor resection prints dummy.
Described step 2) in medical science modeling software be Mimics or Simpleware or
3D-doctor, modeling process uses the voxel split plot design automatically and manually combined, in conjunction with handing over
Mutually formula segmentation and ablation, expansion form operation reconstruct three-dimensional digital model.Described step 3)
In image registration complete in common reverse engineering software: Geomagic studio or
RapidForm or CopyCAD or Imageware.Described step 4) in dummy internal micro-
Seeing porous design to be completed by solidworks or Pro-e or UG, Finite Element Simulation Analysis is tied
Close Abaqus or Ansys or Adina or Msc to implement.Described step 5) in forming material
Material is polyether-ether-ketone or hydroxyapatite or calcium sulfate or its thing material or implantable metal material,
Printing shaping mode is DMLS or SLM or takes metal/hydroxyapatite printing to fill skeletonization and lure
Guided cell.
The invention have the benefit that by utilizing reconstruction of medical images and 3D to print skill
Art design bone defect healing body, has individuation customization and maximum anatomic form coupling is excellent
Gesture；Rebuild and CAD design in conjunction with digital medical, carry out pre-operative surgical rule the most intuitive and reliablely
Draw, and obtain dummy reference model the most accurately according to this, retain bone amount to greatest extent,
Reduce the incidence of clinical complication；The design of the loose structure related to, for bone-dummy wound
Make the most rational Integrated implant microenvironment, beneficially later stage bone uptake, compare tradition dummy more
Tool biological superiority；By Finite Element Simulation Analysis, the porous microstructure solving stiffness optimization is new
Implant repaired by type, compares tradition dummy more mechanical advantage.
The above, the only detailed description of the invention of the present invention, but protection scope of the present invention is also
It is not limited to this, any change expected without creative work or replacement, all should contain
Within protection scope of the present invention.
Claims (5)
1. the bone tumour defect repair implant that rigidity is controlled designs and a forming method, and it is special
Levy and be: comprise the steps:
1) image acquisitions and pretreatment: Ipsilateral and corresponding strong side are carried out standard CT/MR
Scanning, obtains target site original fault image Dicom formatted data and uses median filtering method
Eliminate impulsive noise and salt-pepper noise, then ask second order to lead with Gauss-Laplace conversion denoising
Vowing, the zero crossing led with second order determines and protects signal edge；
2) Ipsilateral tumor resection is postoperative and mirror image defect repair is rebuild with reference to three-dimensional digital model,
Pretreated Dicom data are imported medical science modeling software, determines pixel by Threshold segmentation
Intensity value ranges, utilizes region to increase and separates the discrete voxel of removal, Interactive Segmentation low resolution
Image determines target area border, in conjunction with ablation, expands and smooths morphological operation and finally obtain
Ipsilateral and corresponding strong side object construction precisely emulate three-dimensional digital model, by strong side object construction
It is copied to Ipsilateral by emulation module sagittal plane image feature, generates the three-dimensional that defect area is repaired
Mathematical model, further according to the good osteotomy programme of Design at Ipsilateral virtual osteotomy to obtain
Bone tumour resection postoperative bony structure model, exports as STL form by model；
3) bone defect healing body Model reverse-engineers and hypostazation: by step 2) the middle STL obtained
Model file imports reverse engineering software further, according to the reference point registered before by bone tumour
After resection, model and mirror image defect repair reference model carry out preliminary images registration, in conjunction with inverse
Three-dimension space image in engineering software merges registration function, analysis and solution two model maximum weight
Stack is amassed, it is thus achieved that optimum intersection figure registrates, then two models after registration are carried out Boolean calculation and tried to achieve
Bone defect healing body Model, utilizes reverse engineering software polygon functional module by bone defect healing
Body Model is filled with, relaxes, light genial open manifold operation optimization curved surface, then edit outline line,
Constructing curve sheet, the structure final fitting surface of grid generate hypostazation model；
4) design of dummy interior microscopic porous and Finite Element Simulation Analysis: by step 3) in
The bone defect healing body STP model generated imports CAD software, with reference to current standardized porous
Structural design elements, carries out cutting operation by bone defect healing body, and according to implant reparation
Porosity is controlled in certain limit by target area, it is thus achieved that the porous microstructure bone of different shape lacks
Damage dummy model, then the porous dummy model built is imported finite element analysis software, enter
Row material assignment, stress and strain model, boundary condition and load set, the more certain bar of simulation analysis
Under part diverse microcosmic form porous dummy rebuild repairing bone defect time stress, change in displacement,
Solve the loose structure design that individuation stiffness characteristics is optimum；
5) bone tumour resection postoperative defective region porous repairs the 3D printing shaping of implant: select
Rapid shaping technique and moulding material, by step 4) in try to achieve optimum porous design reparation
Body Model imports 3D printing-forming system, on-demand utilize pre-processing software generate corresponding rationally
Support and printing shaping, then be supported removing, print post processing to obtain the bone of stiffness optimization
Tumour defect 3D prints porous and repairs implant.
The bone tumour defect repair implant design that rigidity the most according to claim 1 is controlled
And forming method, it is characterised in that: described step 2) in medical science modeling software be Mimics
Or Simpleware or 3D doctor, modeling process uses the voxel automatically and manually combined
Split plot design, reconstructs 3-dimensional digital mould in conjunction with Interactive Segmentation and ablation, expansion form operation
Type.
The bone tumour defect repair implant design that rigidity the most according to claim 1 is controlled
And forming method, it is characterised in that: described step 3) in image registration common inverse
Complete in engineering software: Geomagic studio or RapidForm or CopyCAD or
Imageware。
The bone tumour defect repair implant design that rigidity the most according to claim 1 is controlled
And forming method, it is characterised in that: described step 4) in dummy interior microscopic porous design
Completed by solidworks or Pro e or UG, Finite Element Simulation Analysis combine Abaqus or
Ansys or Adina or Msc implements.
The bone tumour defect repair implant design that rigidity the most according to claim 1 is controlled
And forming method, it is characterised in that: described step 5) in moulding material be polyether-ether-ketone or
Hydroxyapatite or calcium sulfate or its thing material or implantable metal material, printing shaping mode is
DMLS or SLM or take metal/hydroxyapatite to print to fill osteogenic induction cell.
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