CN106683549A - Aneurysm model based on 3D printing and manufacturing method thereof - Google Patents
Aneurysm model based on 3D printing and manufacturing method thereof Download PDFInfo
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- CN106683549A CN106683549A CN201611143483.6A CN201611143483A CN106683549A CN 106683549 A CN106683549 A CN 106683549A CN 201611143483 A CN201611143483 A CN 201611143483A CN 106683549 A CN106683549 A CN 106683549A
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- aneurysm
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
Abstract
The invention discloses an individual aneurysm model obtained through 3D printing technology and a manufacturing method thereof. The manufacturing method comprises the steps of firstly, performing high-precision layered scanning on an artery of an aneurysm patient by means of imaging equipment, thereby aneurysm image data; then performing sorting by means of inverse reconstruction software for obtaining the artery, and performing three-dimensional reconstruction; performing expansion amplification on the reconstructed artery by means of computer-aided 3D design software, then subtracting original blood vessels through Boolean operation, obtaining an empty aneurysm model and outputting a 3D printing identifiable file; and finally printing the aneurysm model by means of different materials through a 3D printer, wherein the size ratio between the aneurysm model and the aneurysm of the patient is 1:1. The aneurysm model obtained through the method can settle a defect of disease model shortage in China and can be applied in the fields of disease teaching, open heart surgery or interventional surgery training, surgery planning, etc. The aneurysm model and the manufacturing method have advantages of user-friendly customization, high accuracy, effective realizing of visuality and touchness, simple process, high forming speed and low cost.
Description
Technical field
The present invention relates to teaching, operative training aneurysm model are prepared, more particularly to a kind of individuality based on 3D printing
Change aneurysm model and preparation method thereof.
Background technology
Aneurysm Digital arteries wall local or diffused abnormal dilatation sample pathology, often occur in aorta ascendens, the arch of aorta,
The position such as chest abdominal aorta and entocranial artery.Aneurysm rupture is one of clinical critical illness, and the aneurysm rupture of sustainer can
Shock is caused in short time, the death rate is high.And intracranial segment aneurysm rupture is more with severe headache First presentation, about 30% patient
Can in the short time herniation secondary and die from outside institute.Aneurysmal diagnosis is often needed by imaging examination, common test mode bag
Include digital subtraction angiography (DSA), magnetic resonance angiography (MRA) and CT angiograms (CTA).Aneurysm rupture can be because of it
Happening part is different with tumorous size form and adopt different therapeutic modalities, can be broadly divided into according to the current equipment difference for adopting
Aneurysm incarcerated operation and interventional embolization.
It is complicated that aneurysmal predilection site is usually present anatomical structure.Sustainer adjoins heart in thoracic cavity, what artery sent
Branch is more and easily there is variation, and entocranial artery system is increasingly complex, and skull bottom artery branch is more, the interspersed god of periarterial
Jing and vein, add the communicating branch with the presence of variation, it is difficult to understood by medico, even if veteran clinical operation doctor is
Need under direct-view or expand and judge under otch direct-view, this just extends operating time, increased operating difficulty and risk.
Current medical education is from traditional framework sex knowledge structure memory mode development to problem-targeted religion
Pattern, more emphasizes the teaching pattern of individuation and patient-centered health care.However, the complexity and the country due to clinical disease
Corpse donation rate is low, and domestic clinical medical education is more also based on oral statement and the image simulation of teacher.
Standardized reverse mould mode is adopted the manufacture of traditional medicine model more.This processing mode step is various, and technique is multiple
It is miscellaneous, it is its advantage for the standardized normal human's structure of batch making, it is not suitable for individuation, complication, diversified disease
Disease model.
The auxiliary that medical science 3D printing technique passes through image technology data, appliance computer aided design techniques are fictionalized treats structure
The three-dimensional structure of body is built, then using corresponding material, a kind of organizational engineering technology of entity is successively created that.3D printing skill
Art has in terms of morphology and represents ability well, can make up the blank of disease dissec shortage, contributes to clinical medicine
Correct understanding of the raw or doctor to disease, contributes to cultivating surgical operative skill.
The content of the invention
The present invention is for the deficient present situation of prior art deficiency, high cost and China's disease model, it is proposed that one kind is based on
The aneurysm model of 3D printing, with and preparation method thereof.
The complete technical scheme of the present invention includes：
The aneurysm of differentially expanding, described in a kind of aneurysm model, including the blood vessel and cavity blood vessel vascular wall of cavity
Cavity vascular morphology it is identical with the blood vessel of patient.
Described blood vessel can include a plurality of branch vessel of different sizes, also can not include.
Described blood vessel, its pipe thickness about 1-7mm, its length about 1-2000mm.
Described aneurysm can be one or more in spherical, hemispherical, long rod, fusiformis or lobulated.
Described aneurysm is hollow, and knurl wall is a vascular wall part.
Above-described aneurysm model can be presented one or more in red, yellow, white, blue or Transparent color.
Above-described aneurysm model can present because material is different it is hard, tough or soft in one or more.
Above-described aneurysm model is used for medical teaching, intervention operative training, the training of direct-view aneurysm surgery or art
Front simulation is drilled.
Above-described aneurysm model preparation method, it is characterised in that comprise the steps：
Step one, using image documentation equipment to aneurysm patient vessel's Jing row thin layer scannings, obtain patient vessel's image file
Data；
Step 2,3D reverse-engineering process is carried out to the data for being obtained using 3D reverse engineering softwares, sub-elected comprising dynamic
The upstream and downstream blood vessel of arteries and veins knurl；
Step 3, the 3D designs for being carried out outside expansion to patient vessel using 3D design softwares, coefficient of expansion 1-7mm is pressed
Expand according to former profile is retained；
Boolean calculation is carried out after step 4, expansion, its script blood vessel is deducted and is obtained closed cavity blood vessel；
Step 5, the front cover for deleting blood vessel proximal part and distal end, obtain the cavity blood vessel of insertion, output file；
Step 6, by output file import 3D printer, print aneurysm model using 3D printing raw material
Described image documentation equipment is CT, DSA or MRI, and described patient's head image file data form is DICOM.
3D reverse engineering softwares described in step 2 is a kind of in Mimics or Slicer softwares, in step 3 to step 5
It is STL forms that the 3D design softwares are a kind of in 3-matic, Magics or Geomagic software, described file.
In described step six, beaten as 3D with PLA, acrylonitrile-butadiene-styrene copolymer or photosensitive resin
The raw material of print.
Advantage of the present invention relative to prior art be：
1. individuation：Then the present invention obtains aneurysm mould by the data of collection aneurysm patient by three-dimensional reconstruction
Type, data source is in individual patients, and the aneurysm model for finally giving is also highly consistent with aneurysm morphology in patient's body, thus
With individuation feature；
2. precision:After rebuilding to the data that patient gathers, according to 1：1 size is sorted, and is being entered
Delete during the Boolean calculation of row three-dimensional data for endovascular three-dimensional data, the aneurysm morphology for obtaining and artery in patient's body
Knurl form is highly consistent, can accurately reflect pathology truth.
3. visual tactileization:This model is obtained by 3D printing technique, can present different colors according to different materials, very
To being observed by Transparent color for some endovascular interlayers, the model for obtaining also can be seen from different visual angles
Examine, 360 degree without dead angle；Print additionally by machine on different materials, different hardness can be presented, be more beneficial for understanding soft group of blood vessel
The extension characteristics knitted.
4. process is simple:The method of the invention flow process can be standardized, and it is less to be related to Software tool, and is three-dimensional
The lower operation of direct-view, it is not necessary to grasp and replicate programing work, and 3D printing program also can be full-automatic, it is only necessary to import three-dimensional data just
Be available on the machine full-automatic printing.
5. Quick-forming:Aneurysm model obtained by the present invention is realized using 3D printing technique, is characterized in being layered increasing
Material is manufactured, it is not necessary to complicated pour mask process, particularly with tiny multi-branched cavity artery, along with making for water-soluble support
With the blood vessel after printing only needs to be put in water the dismounting that support is completed by immersion, saves the substantial amounts of time.
6. low cost:The inventive method can standardized program, 3D printing higher level be also automation, when saving substantial amounts of
Between cost, improve make efficiency；Meanwhile, 3D printing technique belongs to " increasing material manufacturing ", does not produce tradition cutting engraving and manufactured
" leftover pieces " substantial amounts of in journey.
Description of the drawings
Fig. 1 is the individuation arch of aorta dissecting aneurysm model front elevation of the present invention；
Fig. 2 is the individuation arch of aorta dissecting aneurysm model side view of the present invention；
Fig. 3 is the schematic perspective view of the individuation arch of aorta artery dissection aneurysm model of the present invention；
Fig. 4 is the front elevation of the individuation aneurysm of internal carotid artery model of the present invention；
Fig. 5 is the side view of the individuation aneurysm of internal carotid artery model of the present invention；
The schematic perspective view of the individuation aneurysm of internal carotid artery model of Fig. 6 present invention.
In figure：1st, dissecting aneurysm of aorta；2nd, the arch of aorta；3rd, coronary artery；4th, left subclavian artery；5th, left neck is total
Artery；6th, truncus brachiocephalicus；7th, carotid artery aneurysms；8th, internal carotid.
Specific embodiment
With reference to specific embodiment, the present invention will be further described.
As shown in Figure 1, 2, 3, one kind prepares individuation aneurysm model and its method to embodiment 1 using 3D printing technique,
Concrete grammar is as follows：
1) thin layer scanning is carried out to the patient chest blood vessel with Aortic arch aneurysm using CTA, sweep limits is covered
The dissecting aneurysm 1 of patient, the arch of aorta 2, and the arch of aorta 3 and its branch's left subclavian artery 4, LCC 5, head arm
Dry 6, obtain DICOM format data file of the patient comprising three-dimensional information data.
2) the DICOM format view data of acquisition is stored in into CD or DVD, imports to the Medical hands of Mimics 17.0
In art design software (Materialise companies, Belgium), import data procedures and select atraumatic fashion, to comprising artery dissection
The regional vessel of knurl carries out 3-D view modeling.
3) 3-dimensional image model for creating is copied to into 3-Matic 9.0 (Materialise companies, Belgium) software
In, bulge outward modeling is carried out, the coefficient of expansion is 2mm, and is chosen " retaining former profile ".
4) former vascular pattern is deducted by the vascular pattern for obtaining is expanded by Boolean calculation in 3-Matic softwares, obtains close
The cavity vascular pattern dissecting aneurysm 1 closed, the arch of aorta 2, coronary artery 3, left subclavian artery 4, LCC 5, head
Arm dry 6.
5) using the proximal part for wiping out function excision blood vessel and the front cover of distal end of 3-Matic softwares, pipeline sample is obtained
Blood vessel, is output as STL forms.
6) STL formatted files are imported into printer (XYZprinting, Taiwan) and carries Slice Software, addition automatically is supported
And cut into slices, it is raw material printing using water white transparency photosensitive resin, obtain the 1 of the perfect duplication of this patient:1 aneurysm model.
As shown in Figure 4,5, 6, one kind prepares individuation aneurysm model and its method to embodiment 2 using 3D printing technique,
Concrete grammar is as follows：
1) using MRA to carrying out thin layer scanning with intracranial aneurysm patients head blood vessel, sweep limits includes：Move in neck
Arteries and veins knurl 7, internal carotid 8.Obtain DICOM format data file of the patient comprising three-dimensional information data.
2) the DICOM format view data of acquisition is stored in into CD or DVD, imports to the Medical hands of Mimics 17.0
In art design software (Materialise companies, Belgium), import data procedures and select atraumatic fashion, to comprising aneurysmal
Regional vessel carries out 3-D view modeling, including carotid artery aneurysms 7, internal carotid 8.
3) 3-dimensional image model for creating is copied to into 3-Matic 9.0 (Materialise companies, Belgium) software
In, bulge outward modeling is carried out, the coefficient of expansion is 1mm, and is chosen " retaining former profile ".
4) former vascular pattern is deducted by the vascular pattern for obtaining is expanded by Boolean calculation in 3-Matic softwares, is wrapped
Include the closed cavity vascular pattern of carotid artery aneurysms 7, internal carotid 8.
5) using the proximal part for wiping out function excision blood vessel and the front cover of distal end of 3-Matic softwares, pipeline sample is obtained
Blood vessel, is output as STL forms.
STL formatted files are imported into printer (XYZprinting, Taiwan) and carries Slice Software, addition automatically is supported simultaneously
Section, is raw material printing using red PLA, obtains the 1 of the perfect duplication of this patient:1 aneurysm model.
Many-side involved in the present invention is explained as above.However, it should be understood that without departing from spirit of the invention
Under the premise of, those skilled in the art carry out being equal to change and modification to it, and the change and modification are equally fallen into appended by the application
The coverage of claim.
Claims (14)
1. a kind of preparation method of aneurysm model, it is characterised in that comprise the steps：
Step one, thin layer scanning is carried out to aneurysm patient vessel, obtain patient vessel's file data；
Step 2, the blood vessel file data obtained to step one using 3D reverse engineering approach are processed, and are sub-elected comprising dynamic
The upstream and downstream blood vessel of arteries and veins knurl；
Step 3, the upstream and downstream blood vessel obtained by step 2 is outwards expanded using 3D methods for designing,
Step 4, the blood vessel after expansion is deducted by its script blood vessel by Boolean calculation, obtain hollow vessel post；
Step 5, the proximal part and distal end of deleting hollow vessel post, obtain lumen of vessels, output file；
Step 6, by output file import 3D printer, using 3D printing raw material, print aneurysm model.
2. the method described in claim 1, it is characterised in that the coefficient of expansion 1-7mm expanded described in step 3.
3. the method described in claim 1, it is characterised in that step one carries out thin layer scanning using image documentation equipment, and obtains trouble
The image file data of person's blood vessel.
4. the method described in claim 3, it is characterised in that described image documentation equipment is CT, DSA or MRI, described patient's head
Cranium image file data form is DICOM.
5. the method described in claim 1, it is characterised in that 3D reverse engineering approach described in step 2 be using Mimics or
One kind in Slicer softwares carries out 3D reverse-engineerings, step 3 to 3D methods for designing described in step 5 be using 3-matic,
One kind in Magics or Geomagic softwares carries out 3D designs, and described file is STL forms.
6. the method described in any one of claim 1-5, it is characterised in that in described step six, with PLA, acrylonitrile-
The raw material of BS or photosensitive resin as 3D printing.
7. a kind of blood vessel of aneurysm model, including cavity, the blood vessel of the cavity includes the artery of differentially expanding on vascular wall
Knurl, it is characterised in that described cavity vascular morphology is identical with the blood vessel of originating patient, described cavity blood vessel adopts 3D printing
Method obtain.
8. the model described in claim 7, it is characterised in that described cavity blood vessel can include a plurality of branch of different sizes
Blood vessel, also can not include.
9. the model described in claim 7 or 8, it is characterised in that described cavity blood vessel, its pipe thickness about 1-7mm, its length
Degree about 1-2000mm.
10. the model described in claim 7, it is characterised in that described aneurysm be spherical, hemispherical, long rod, fusiformis or
One or more in lobulated.
Model described in 11. claims 10, it is characterised in that described aneurysm is hollow, and aneurysmal knurl wall is blood vessel
A wall part.
Model described in 12. any one of claim 7-11, it is characterised in that described aneurysm model can present it is red, yellow,
In vain, one or more in blue or Transparent color.
Model described in 13. any one of claim 7-11, it is characterised in that described aneurysm model can be because material be different
One or more during presentation is hard, tough or soft.
Aneurysm model described in 14. any one of claim 7-13 aneurysm under medical teaching, intervention operative training, direct-view
Application in operative training or preoperative simulated maneuver.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107134207A (en) * | 2017-06-19 | 2017-09-05 | 深圳市六联科技有限公司 | The method and its model of a kind of human body organ three-dimensional printing |
| CN107616839A (en) * | 2017-11-10 | 2018-01-23 | 岳春华 | A kind of flap perforating artery localization method rebuild based on 3D printing |
| CN107837130A (en) * | 2017-11-28 | 2018-03-27 | 严中亚 | It is a kind of it is quick prepare for treat aortic arch interlayer art in individuation overlay film frame method |
| CN108210072A (en) * | 2018-02-08 | 2018-06-29 | 扈玉华 | The preparation method of brain tissue and blood vessel entity composite model based on MRI and CTA |
| CN108339181A (en) * | 2018-01-09 | 2018-07-31 | 浙江省肿瘤医院 | A method of preparing tracheal tube using digitlization Space Reconstruction and 3D printing technique |
| CN110379274A (en) * | 2019-07-15 | 2019-10-25 | 北京工业大学 | A kind of aneurysm experimental model and production method for flow observation |
| WO2020083374A1 (en) * | 2018-10-26 | 2020-04-30 | Union Strong (Beijing) Technology Co. Ltd. | Method and system for measuring morphological parameters of an intracranial aneurysm image |
| CN111227931A (en) * | 2020-01-08 | 2020-06-05 | 西安马克医疗科技有限公司 | 3D model construction method and preparation method for aortic valve diseases |
| CN111227930A (en) * | 2020-01-08 | 2020-06-05 | 西安马克医疗科技有限公司 | 3D model construction and preparation method for mitral regurgitation and calcified stenosis |
| CN112562073A (en) * | 2020-12-28 | 2021-03-26 | 天津市第一中心医院 | Relation model of deep brain tumor and white matter fiber bundle and preparation method thereof |
| CN112669687A (en) * | 2020-12-01 | 2021-04-16 | 大连理工大学 | Method for manufacturing personalized in-vitro interlayer physical model |
| CN113920835A (en) * | 2021-10-12 | 2022-01-11 | 青岛三易三维技术有限公司 | Human body model making method and system for interventional operation training based on 3D printing |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107134207A (en) * | 2017-06-19 | 2017-09-05 | 深圳市六联科技有限公司 | The method and its model of a kind of human body organ three-dimensional printing |
| CN107616839A (en) * | 2017-11-10 | 2018-01-23 | 岳春华 | A kind of flap perforating artery localization method rebuild based on 3D printing |
| CN107837130A (en) * | 2017-11-28 | 2018-03-27 | 严中亚 | It is a kind of it is quick prepare for treat aortic arch interlayer art in individuation overlay film frame method |
| CN108339181A (en) * | 2018-01-09 | 2018-07-31 | 浙江省肿瘤医院 | A method of preparing tracheal tube using digitlization Space Reconstruction and 3D printing technique |
| CN108210072A (en) * | 2018-02-08 | 2018-06-29 | 扈玉华 | The preparation method of brain tissue and blood vessel entity composite model based on MRI and CTA |
| WO2020083374A1 (en) * | 2018-10-26 | 2020-04-30 | Union Strong (Beijing) Technology Co. Ltd. | Method and system for measuring morphological parameters of an intracranial aneurysm image |
| CN110379274A (en) * | 2019-07-15 | 2019-10-25 | 北京工业大学 | A kind of aneurysm experimental model and production method for flow observation |
| CN111227931A (en) * | 2020-01-08 | 2020-06-05 | 西安马克医疗科技有限公司 | 3D model construction method and preparation method for aortic valve diseases |
| CN111227930A (en) * | 2020-01-08 | 2020-06-05 | 西安马克医疗科技有限公司 | 3D model construction and preparation method for mitral regurgitation and calcified stenosis |
| CN112669687A (en) * | 2020-12-01 | 2021-04-16 | 大连理工大学 | Method for manufacturing personalized in-vitro interlayer physical model |
| CN112669687B (en) * | 2020-12-01 | 2022-06-21 | 大连理工大学 | Method for manufacturing personalized in-vitro interlayer physical model |
| CN112562073A (en) * | 2020-12-28 | 2021-03-26 | 天津市第一中心医院 | Relation model of deep brain tumor and white matter fiber bundle and preparation method thereof |
| CN113920835A (en) * | 2021-10-12 | 2022-01-11 | 青岛三易三维技术有限公司 | Human body model making method and system for interventional operation training based on 3D printing |
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Application publication date: 20170517 |