CN110039050A - A kind of specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof - Google Patents

A kind of specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof Download PDF

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Publication number
CN110039050A
CN110039050A CN201910304035.7A CN201910304035A CN110039050A CN 110039050 A CN110039050 A CN 110039050A CN 201910304035 A CN201910304035 A CN 201910304035A CN 110039050 A CN110039050 A CN 110039050A
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module
model
cad
tissue engineering
engineering bracket
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曹博强
贺镜羽
汪漫
牛丽文
金利玉
李洪兵
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Sir Run Run Hospital Nanjing Medical University
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Sir Run Run Hospital Nanjing Medical University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/10—Formation of a green body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/80—Data acquisition or data processing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/22—Driving means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/40—Radiation means
    • B22F12/44—Radiation means characterised by the configuration of the radiation means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/40—Radiation means
    • B22F12/49—Scanners
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00—Data acquisition or data processing for additive manufacturing
    • B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/20—Design optimisation, verification or simulation
    • G06F30/23—Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

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Abstract

The present invention relates to human-body biological field of engineering technology, in particular a kind of specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof, including the 3D printing equipment for printed product and for the graphics process panel of graphics process.The specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof, using the method for 3D printing titanium alloy, make Auricular framework, it prepares to improve auricle reconstruction surgery mode outside common microtia at present later, greatly simplifie the tedious steps of Auricular framework production, reduce operating difficulty, shorten operating time, reduce the generation of complication, physical model is made in titanium alloy material printing by way of 3D printing, so that physical model is firmer, precision is higher, engineering rack is network simultaneously, it is to carry out subregion according to model with the structure snd size of normal auricle, it is convenient for and shape is carried out to different zones, the adjustment of density etc..

Description

A kind of preparation facilities of the tissue engineering bracket of specific modality and structure and its preparation Method
Technical field
The present invention relates to human-body biological field of engineering technology, the tissue engineering bracket of specially a kind of specific modality and structure Preparation facilities and preparation method thereof.
Background technique
The basis of the treatment of congenital microtia is outer total auricular reconstruction.Normal auricle is by thin thin skin soft tissue packet It wraps up in elastic cartilage bracket to be formed, flexible shell structure, and by helix, anthelix, tragus, antitragus, ear-lobe, ear First, fossa triangularis, navicula etc. are constituted, convex-concave convolution, complex shape, therefore total auricular reconstruction is a difficulty, complicated operation.Mesh Preceding clinical main modus operandi to be applied first is that brent-nagata method, spliced by intercepting patient part's costal cartilage, Engraving, is fabricated to auricle form, by stages row reconstruction of auricle.Although row reconstruction of auricle can be produced non-with normal auricle form Normal reconstruction ear, but there are many factor for influencing reconstruction ear form, the elastic of skin, thickness, size etc. after residual ear and residual ear, these Condition can all influence the effect of operation.Costal cartilage itself is taken to have compared with major trauma patient, postoperative costal cartilage of leaving lacks such as, inevitably right Life brings inconvenience later.And the difficult point as the operation, cut, rib all very big with the length, shape, thickness difference of costal cartilage The engraving of cartilage is handled, and is even more required to the aesthetic of surgical doctor and with knife skill very high.In consideration of it, it is proposed that a kind of specific Form and the preparation facilities of tissue engineering bracket of structure and preparation method thereof.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation facilities of the tissue engineering bracket of specific modality and structure and its systems Preparation Method, with solve it is mentioned above in the background art take costal cartilage itself to have compared with major trauma patient, it is postoperative to leave costal cartilage The problem of lacking such as, inevitably bringing inconvenience to later life.
To achieve the above object, on the one hand, the present invention provides a kind of system of the tissue engineering bracket of specific modality and structure Standby device, including the 3D printing equipment for printed product and for the graphics process panel of graphics process, the 3D printing Include lens vibrating type laser scanning system in equipment, includes three-dimensional graph process module in the graphics process panel, described three Tieing up pattern process module includes core graphic processing module, grid generation module, curved surface modeling module, CAD module and physics mould Block；
The core graphic processing module is used to 3D rendering data carrying out image viewing, and measures and handle；
The grid generation module is used to the 3D rendering data after segmentation being converted to manifold volume mesh, and exports And it is applied to finite element or cfdrc packet；
The curved surface modeling module converts image to CAD data；
The CAD module is used for merging CAD model and 3-D image, and geometrical model obtained can export CAD File format model automatically generates numerous finite element grids, carries out CAD modeling；
The physical module is for calculating effective elastoplastic property, absolute permeability, conductivity and dielectric constant, thermally conductive system Several and coefficient of molecular diffusion, and export as text or VTK formatted file.
As a preferred solution of the present invention, the CAD module includes file import modul, grid dividing module, phase To locating module and distance-measurement module；
The file import modul is for CAD file format to be importing directly into 3-D image；
The grid dividing module, which is used to be exported built-up pattern in the form of STL or imports ScanIP, does further volume mesh stroke Point；
The relative positioning module is used to carry out location simulation to stent model and product model；
The distance-measurement module is for measuring the distance between stent model and product model.
As a preferred solution of the present invention, the physical module include structural mechanics module, fluid analysis module and More scientific analysis modules；
The structural mechanics module is for calculating material effective rigidity tensor sum elasticity modulus；
The fluid analysis module is for calculating the parameters such as porous media permeability；
Material behavior corresponding effective material parameter of the more scientific analysis modules for control.
As a preferred solution of the present invention, the lens vibrating type laser scanning system include system actuating motor module, Optical system module, control algolithm module and figure adjustment module；
The system actuating motor module is used to form a position follower servo-system, guarantees scanning system quick and precisely Positioning；
The Optical system module is used to carry out laser scanning according to the threedimensional model of object；
The control algolithm module is used for the dynamic response of control system actuating motor；
The figure adjustment module is for being corrected the figure of scanning.
As a preferred solution of the present invention, the system actuating motor module includes motor torque balance module, electricity Armature balance module and motor drive module；
The motor torque balance module is used to control the torque balance of motor；
The armature balance module is used to control the armature balance of motor；
The motor drive module works for driving motor.
As a preferred solution of the present invention, the control algolithm module includes that discrete model algoritic module and newton insert Value-based algorithm module；
The discrete model algoritic module is for establishing correct topological relation between data；
The Newton Interpolation Algorithm module is used to calculate the dispersion degree of data.
On the other hand, the present invention also provides a kind of preparation methods of the tissue engineering bracket of specific modality and structure, including The preparation facilities of the tissue engineering bracket of specific modality described in above-mentioned any one and structure, its step are as follows:
S1, using human body scanning device, the specific shape part manufactured to needs is scanned, to tentatively be needed Establish the 3D illustraton of model at the position of bracket；
S2,3D illustraton of model made from step S1 is imported in graphics process panel, by core graphic processing module by 3D Image data carries out image viewing, and measures and handle, the 3D after being used to divide by the grid generation module Image data is converted to manifold volume mesh, and exports and be applied to finite element or cfdrc packet, passes through Curved surface modeling module converts image to CAD data, by CAD module merging CAD model and 3-D image, is obtained The geometrical model obtained can export CAD file format model, automatically generate numerous finite element grids, carry out CAD modeling；
S3, Titanium Powder powder material is added to 3D printing equipment, a position is formed by system actuating motor module Servo-actuated servo-system is set, guarantees that scanning system fast and accurately positions, the three-dimensional according to object is used for by Optical system module Model carries out laser scanning, and the dynamic response of control system actuating motor is used for by control algolithm module, passes through figure adjustment Module forms the tissue engineering bracket of specific modality and structure for being corrected to the figure of scanning.
As a preferred solution of the present invention, the human body scanning device in the step S1 is CT tomography scanner.
As a preferred solution of the present invention, the Titanium Powder powder material in the step S3 is FSTi6Al4V.
Compared with prior art, beneficial effects of the present invention:
1, the specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof are closed using 3D printing titanium The method of gold makes Auricular framework, and for improvement later, the outer auricle reconstruction surgery mode of common microtia is prepared at present, maximum Feature is that the step of thoracic operation takes costal cartilage is omitted, greatly simplifies the tedious steps of Auricular framework production, reduce Operating difficulty shortens operating time, reduces the generation of complication, provide the selection of more modus operandis for patient and family members, It has a good application prospect and the market demand.
2, the specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof pass through the side of 3D printing Physical model is made in titanium alloy material printing by formula, so that physical model is firmer, precision is higher, while engineering rack is grid Structure is to carry out subregion according to model with the structure snd size of normal auricle, is convenient for and carries out shape, density to different zones Etc. adjustment.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention；
Fig. 2 is three-dimensional graph process module map of the invention；
Fig. 3 is CAD module map of the invention；
Fig. 4 is physical module figure of the invention；
Fig. 5 is lens vibrating type laser scanning system figure of the invention；
Fig. 6 is system actuating motor module map of the invention；
Fig. 7 is control algolithm module map of the invention；
Fig. 8 is Optical system module dynamic focusing schematic diagram of the invention；
Fig. 9 is the tissue engineering bracket overall structure diagram of specific modality and structure of the invention；
Figure 10 is the tissue engineering bracket partial structural diagram of specific modality and structure of the invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside", " up time The orientation or positional relationship of the instructions such as needle ", " counterclockwise " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of The description present invention and simplified description, rather than the equipment of indication or suggestion meaning or element must have a particular orientation, with spy Fixed orientation construction and operation, therefore be not considered as limiting the invention.
In the description of the present invention, the meaning of " plurality " is two or more, unless otherwise specifically defined.
Embodiment 1
The present invention provides a kind of preparation facilities of the tissue engineering bracket of specific modality and structure, as Figure 1-Figure 2, packet The 3D printing equipment for printed product and the graphics process panel for graphics process are included, includes vibration in 3D printing equipment Mirror laser scanning system, interior graphics process panel includes three-dimensional graph process module, and three-dimensional graph process module includes core Pattern process module, grid generation module, curved surface modeling module, CAD module and physical module, core graphic processing module are used for 3D rendering data are subjected to image viewing, and measures and handles, grid generation module is for the 3D rendering after dividing Data are converted to manifold volume mesh, and export and be applied to finite element or cfdrc packet, curved surface modeling Module converts image to CAD data, and CAD module is used for merging CAD model and 3-D image, geometry obtained Model can export CAD file format model, automatically generate numerous finite element grids, carry out CAD modeling, physical module is based on Effective elastoplastic property, absolute permeability, conductivity and dielectric constant, thermal coefficient and coefficient of molecular diffusion are calculated, and is exported as Text or VTK formatted file.
In the present embodiment, three-dimensional graph process module is based on Simpleware software design, and ScanIP is 3D rendering data Image viewing, measurement and handling implement provide wide in range selection, treated, and image can export as STL or point Yun Wen Part is applied to CAD analysis, solution and 3D printing field.
Further, grid generation module is based on Simpleware+FE module design, and Simpleware+FE module has The powerful mesh generation ability based on image, provides high quality solution, the 3D rendering data after segmentation is converted to more Partial volume mesh exports and is applied to finite element (FE) or Fluid Mechanics Computation (CFD) software package, and the grid of generation has The interface and shared node of inhibition may specify material properties, definition contact, node collection and shell unit, and defines CFD perimeter strip Part accelerates the workflow of user by reducing the step of other software draw grid again.
Specifically, based on+nurbs surface modeling module design ,+nurbs surface modeling module provides a kind of from image A kind of approach converted to CAD data, by creating NURBS (Non-UniformRationalB-Splines) model, the collection ROI (regionofinterest) area-of-interest is converted to automatic Fitting Surface Creation technology at module NURBSIGES file can be directed into CAD software after conversion.
It is worth noting that the SLM printer of the model FS271M of 3D printing equipment useization daybreak high-tech production, this dozen Print machine printing effect is good, is convenient for metal powder printing.
The three-dimensional graph process module of the preparation facilities of the tissue engineering bracket of specific modality and structure in the present embodiment When in use, 3D rendering data are carried out by image viewing by core graphic processing module, and measures and handles, passed through 3D rendering data after segmentation are converted to manifold volume mesh by grid generation module, and export and be applied to finite element or Cfdrc packet is converted image to CAD data by curved surface modeling module, by CAD module by CAD mould Type is merged with 3-D image, and geometrical model obtained can export CAD file format model, automatically generates numerous finite elements Grid, carry out CAD modeling, by physical module calculate effective elastoplastic property, absolute permeability, conductivity and dielectric constant, Thermal coefficient and coefficient of molecular diffusion, and export as text or VTK formatted file.
Embodiment 2
As second of embodiment of the invention, debugged for the ease of importing 3-D graphic in CAD software, this hair Bright personnel make improvements CAD module, as a kind of preferred embodiment, as shown in figure 3, CAD module include file import modul, Grid dividing module, relative positioning module and distance-measurement module, file import modul is for CAD file format to be introduced directly into Into 3-D image, grid dividing module, which is used to be exported built-up pattern in the form of STL or imports ScanIP, does further volume mesh It divides, relative positioning module is used to carry out location simulation to stent model and product model, and distance-measurement module is for measuring branch The distance between frame model and product model.
The CAD module of the preparation facilities of the tissue engineering bracket of specific modality and structure in the present embodiment when in use, CAD file format is importing directly into 3-D image by file import modul, is led in the form of STL by grid dividing module Built-up pattern or importing ScanIP do further volume mesh and divide out, by relative positioning module to stent model and product model Location simulation is carried out, the distance between stent model and product model are measured by distance-measurement module.
Embodiment 3
As the third embodiment of the invention, for the ease of analyzing physical parameter, the present invention staff is to physics Module makes improvements, as a kind of preferred embodiment, as shown in figure 4, physical module includes structural mechanics module, fluid analysis mould Block and more scientific analysis modules, structural mechanics module is for calculating material effective rigidity tensor sum elasticity modulus, fluid analysis mould Block is for calculating the parameters such as porous media permeability, the corresponding effective materials of material behavior for analysing module scientifically for control more Parameter.
In the present embodiment, structural mechanics module calculates material effective rigidity tensor sum elasticity modulus, calls built in software Finite element solving device executes numerical homogenization calculating using the quick semi analytical method based on segmented image.
Further, fluid analysis module calculates the parameters such as porous media permeability, and numerical homogenization, which calculates, calls software Built-in Stokes solver.
Specifically, mostly scientific analysis module calculates the corresponding effective material ginseng of material behavior controlled by Laplace equation Number, including but not limited to conductivity, dielectric constant, the coefficient of heat conduction, diffusion coefficient etc., using the finite element solving built in software Device executes numerical homogenization calculating based on the quick semi analytical method of segmented image.
Physical module core function table
Physical module Character Comparison table
Structural mechanics module Fluid analysis module More scientific analysis modules
Generate the volume mesh of high quality √ √ √
Gray value material map √
Calculate effective elasticity number √
Calculate permeability coefficient √
Calculate electrical parameter and thermal parameter √
Visualize finite element modelling result √ √ √
The physical module of the preparation facilities of the tissue engineering bracket of specific modality and structure in the present embodiment when in use, Material effective rigidity tensor sum elasticity modulus is calculated by structural mechanics module, porous media is calculated by fluid analysis module and is seeped The parameters such as saturating rate, by the corresponding effective material parameter of material behavior for more analysing module control scientifically.
Embodiment 4
As the 4th kind of embodiment of the invention, for the ease of carrying out 3D laser printing, the present invention staff swashs mirror-vibrating Photo-scanning system makes improvements, as a kind of preferred embodiment, as shown in figure 5, lens vibrating type laser scanning system includes that system is held Row motor module, Optical system module, control algolithm module and figure adjustment module, system actuating motor module are used to form one A position follower servo-system guarantees that scanning system fast and accurately positions, and Optical system module is used for the three-dimensional according to object Model carries out laser scanning, and control algolithm module is used for the dynamic response of control system actuating motor, and figure adjustment module is used for The figure of scanning is corrected.
In the present embodiment, actuating motor module uses moving-magnetic type motor, its stator is by stator winding and conducting magnet core group At the radial magnetic field of one certain number of poles of formation；Rotor is by set of permanent magnets at formation radial magnetic field corresponding with magnetic pole of the stator.
Further, Optical system module optical mirror slip includes the poly- of off axis reflector eyeglass and composition dynamic focusing system Focus lens and object lens, effective optical aperture needed for reflecting mirror depend primarily on the effective diameter of scanning light beam, due to light beam with Angled relationships between reflecting mirror, shape of the light beam in mirror surface are not always that circle is, therefore is determining having for reflecting mirror When imitating aperture, always to make it bigger than the diameter of light beam, the diameter of scanning light beam depends on the use purpose of entire optical system, Biggish light beam dynamic focusing system is needed when focusing distance is longer to be made of moveable focus lamp and fixed object lens, It is focused by the movement of focus lamp, amplifies the adjustment effect of focus lamp by object lens.
Specifically, Optical system module model is as shown in figure 8, wherein L1, L2, due in dynamic focussing process, the 3rd Hot spot on lens can change with z, the also corresponding change of the hot spot on probe, if the hot spot on probe to be kept to keep It is constant, L can be made3, according to photo-sensitizer system formula, the relationship between the variable quantity of focal position and lens moving z can be obtained:
Eaily design is to make f2, then the relationship between the variation of focal position and lens moving z can be reduced to
It is worth noting that the material of scan mirror selected by the wavelength and power decision of laser, front end using The 50WCO2 radio frequency laser of SYNRAD company, the U.S., the substrate of x-y axis reflecting mirror use vitreous silica, and laser reflective film uses The features such as silverskin has absorption small, reflectivity height and high resistance to laser-damaged threshold value.
The mirror-vibrating laser of the preparation facilities of the tissue engineering bracket of specific modality and structure in the present embodiment scans system System forms a position follower servo-system when in use, by system actuating motor module, guarantees scanning system quick and precisely Positioning, by Optical system module according to the threedimensional model of object carry out laser scanning, pass through control algolithm module control system The dynamic response of system actuating motor, is corrected by figure of the figure adjustment module to scanning.
Embodiment 5
As the 5th kind of embodiment of the invention, in order to form a position follower servo-system, the present invention staff is to being System actuating motor module makes improvements, as a kind of preferred embodiment, as shown in fig. 6, system actuating motor module includes motor Torque balance module, armature balance module and motor drive module, motor torque balance module are used to control turning for motor Square balance, armature balance module are used to control the armature balance of motor, and motor drive module works for driving motor.
In the present embodiment, motor torque balance module equation is
It is the electromagnetic torque of motor in formula, is the rotary inertia of motor, be rotor deflection angle, is inside motor It is folded to the viscosity friction coefficient on motor shaft with motor load, is torsion bar coefficient of elasticity.
Further, armature balance module equation is
In formula, it be armature supply river is armature inductance that control voltage, R, which is armature resistance, for armature counter electromotive force, is Counter electromotive force of motor coefficient is the anti-emf coefficient of motor.
Specifically, motor drive module transmission function is
The system actuating motor module of the preparation facilities of the tissue engineering bracket of specific modality and structure in the present embodiment When in use, the torque balance that motor is controlled by motor torque balance module controls motor by armature balance module Armature balance, by motor drive module for driving motor work.
Embodiment 6
As the 6th kind of embodiment of the invention, in order to realize the dynamic response of control system actuating motor, the present inventor Member makes improvements control algolithm module, as a kind of preferred embodiment, as shown in fig. 7, control algolithm module includes walk-off-mode Type algoritic module and Newton Interpolation Algorithm module, discrete model algoritic module is for establishing correct topological relation between data, ox Interpolation algorithm module of pausing is used to calculate the dispersion degree of data.
In the present embodiment, discrete model algoritic module transmission function isSampling period is Discretization: 0.1s is calculated by formula x (k+1)=(G-Hc) x (k)+Hr (k).
Further, Newton Interpolation Algorithm modular algorithm is as follows:
Step 1: input node (xj, yj), precision ξ, evaluation point xx, f0 → p, 1 → T, 1 → i；
Step 2: to k=1,2 ... ..., i successively calculates k rank inequality
F [xi-k, xi-k+1 ..., xi]=(f [xi-k+1 ..., xi]-f [xi-k ..., xi])/(xi-xi-k)；
Step 3:(1) if, | f [x1 ..., xi]-f [x0 ..., xi-1] | < ξ, then p is final result Ni-1 (x), remainder Ri-1=f [x0 ..., xi] (xx-xi-1) T
(2), otherwise (xx-xi-1) * T → T, p+f [x0 ..., xi] * T → p, goes to step 4；
Step 4: if i < n, i+1 → i goes to step 2；Otherwise it terminates.
Embodiment 7
On the other hand, the present invention also provides a kind of preparation methods of the tissue engineering bracket of specific modality and structure, including The preparation facilities of the tissue engineering bracket of the specific modality and structure of above-mentioned any one, its step are as follows:
S1, using human body scanning device, the specific shape part manufactured to needs is scanned, to tentatively be needed Establish the 3D illustraton of model at the position of bracket；
S2,3D illustraton of model made from step S1 is imported in graphics process panel, by core graphic processing module by 3D Image data carries out image viewing, and measures and handle, the 3D rendering after being used to divide by grid generation module Data are converted to manifold volume mesh, and export and be applied to finite element or cfdrc packet, pass through curved surface Modeling module converts image to CAD data, obtained by CAD module merging CAD model and 3-D image Geometrical model can export CAD file format model, automatically generate numerous finite element grids, carry out CAD modeling；
S3, Titanium Powder powder material is added to 3D printing equipment, a position is formed by system actuating motor module Servo-actuated servo-system is set, guarantees that scanning system fast and accurately positions, the three-dimensional according to object is used for by Optical system module Model carries out laser scanning, and the dynamic response of control system actuating motor is used for by control algolithm module, passes through figure adjustment Module forms the tissue engineering bracket of specific modality and structure for being corrected to the figure of scanning.
In the present embodiment, the human body scanning device in step S1 is CT tomography scanner.
Further, only for example, the 3D illustraton of model in step S1 can also be mcs format, the format software It is legal to use the authorization needed by obtaining software vendors.
Specifically, the Titanium Powder powder material in step S3 is FSTi6Al4V.
In the present embodiment, tissue engineering bracket has specific shape, and it is false that specific shape is selected from auricle, external nose, ose implant, chin Body and other people body tissues or organ morphology.
In the present embodiment, organizational project branch made from the preparation method using the tissue engineering bracket of specific modality and structure Frame is as shown in Figure 9 and Figure 10, and tissue engineering bracket is made of the parallel net item of multiple groups, and mutual direction is different between every networking item, It is equipped between the net items of difference group and they interweaves the reinforcement structure of connection, tissue engineering bracket is equipped with several reinforcement rib knots Structure, usual four ribs constitute diamond-plaid as reinforcement structure, and diamond-plaid is made of four connection straps, and lateral networking item is serrated Perhaps the wavy longitudinal networking item of string is serrated or string is wavy, and the structure of longitudinal networking item and lateral networking item is essentially identical.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry For personnel it should be appreciated that the present invention is not limited to the above embodiments, described in the above embodiment and specification is only the present invention Preference, be not intended to limit the invention, without departing from the spirit and scope of the present invention, the present invention also has various Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute Attached claims and its equivalent thereof.

Claims (8)

1. the preparation facilities of the tissue engineering bracket of a kind of specific modality and structure, including the 3D printing equipment for printed product And the graphics process panel for graphics process, it is characterised in that: include that mirror-vibrating laser is swept in the 3D printing equipment System is retouched, includes three-dimensional graph process module in the graphics process panel, the three-dimensional graph process module includes core figure Shape processing module, grid generation module, curved surface modeling module, CAD module and physical module；
The core graphic processing module is used to 3D rendering data carrying out image viewing, and measures and handle；
The grid generation module is used to the 3D rendering data after segmentation being converted to manifold volume mesh, and exports and answer For finite element or cfdrc packet；
The curved surface modeling module converts image to CAD data；
The CAD module is used for merging CAD model and 3-D image, and geometrical model obtained can export cad file Format model automatically generates numerous finite element grids, carries out CAD modeling；
The physical module for calculate effective elastoplastic property, absolute permeability, conductivity and dielectric constant, thermal coefficient and Coefficient of molecular diffusion, and export as text or VTK formatted file.
2. the preparation facilities of the tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: institute Stating CAD module includes file import modul, grid dividing module, relative positioning module and distance-measurement module；
The file import modul is for CAD file format to be importing directly into 3-D image；
The grid dividing module, which is used to be exported built-up pattern in the form of STL or imports ScanIP, does further volume mesh division；
The relative positioning module is used to carry out location simulation to stent model and product model；
The distance-measurement module is for measuring the distance between stent model and product model.
3. the preparation facilities of the tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: institute State physical module include structural mechanics module, fluid analysis module and analyse scientifically module；
The structural mechanics module is for calculating material effective rigidity tensor sum elasticity modulus；
The fluid analysis module is for calculating the parameters such as porous media permeability；
Material behavior corresponding effective material parameter of the more scientific analysis modules for control.
4. the preparation facilities of the tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: institute Stating lens vibrating type laser scanning system includes system actuating motor module, Optical system module, control algolithm module and figure adjustment Module；
The system actuating motor module is used to form a position follower servo-system, guarantees that scanning system is fast and accurately fixed Position；
The Optical system module is used to carry out laser scanning according to the threedimensional model of object；
The control algolithm module is used for the dynamic response of control system actuating motor；
The figure adjustment module is for being corrected the figure of scanning.
5. the preparation facilities of the tissue engineering bracket of specific modality according to claim 4 and structure, it is characterised in that: institute Stating system actuating motor module includes motor torque balance module, armature balance module and motor drive module；
The motor torque balance module is used to control the torque balance of motor；
The armature balance module is used to control the armature balance of motor；
The motor drive module works for driving motor.
6. the preparation facilities of the tissue engineering bracket of specific modality according to claim 4 and structure, it is characterised in that: institute Stating control algolithm module includes discrete model algoritic module and Newton Interpolation Algorithm module；
The discrete model algoritic module is for establishing correct topological relation between data；
The Newton Interpolation Algorithm module is used to calculate the dispersion degree of data.
7. a kind of preparation method of the tissue engineering bracket of specific modality and structure, it is characterised in that: appoint including claim 1-6 The preparation facilities of the tissue engineering bracket of specific modality described in meaning one and structure, it is characterised in that: its step are as follows:
S1, using human body scanning device, the specific shape part manufactured to needs is scanned, to tentatively obtain needing to establish The 3D illustraton of model at the position of bracket；
S2,3D illustraton of model made from step S1 is imported in graphics process panel, by core graphic processing module by 3D rendering Data carry out image viewing, and measure and handle, the 3D rendering after being used to divide by the grid generation module Data are converted to manifold volume mesh, and export and be applied to finite element or cfdrc packet, pass through curved surface Modeling module converts image to CAD data, obtained by CAD module merging CAD model and 3-D image Geometrical model can export CAD file format model, automatically generate numerous finite element grids, carry out CAD modeling；
S3, Titanium Powder powder material is added to 3D printing equipment, by system actuating motor module formed a position with Dynamic servo-system, guarantees that scanning system fast and accurately positions, and is used for the threedimensional model according to object by Optical system module Laser scanning is carried out, the dynamic response of control system actuating motor is used for by control algolithm module, passes through figure adjustment module For being corrected to the figure of scanning, the tissue engineering bracket of specific modality and structure is formed.
8. the preparation method of the tissue engineering bracket of specific modality according to claim 7 and structure, it is characterised in that: institute Stating the human body scanning device in step S1 is CT tomography scanner.
CN201910304035.7A 2019-04-16 2019-04-16 A kind of specific modality and the preparation facilities of tissue engineering bracket of structure and preparation method thereof Pending CN110039050A (en)

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Application publication date: 20190723