CN105920569A

CN105920569A - Medicinal composition for treating cough and preparation method thereof

Info

Publication number: CN105920569A
Application number: CN201610485346.4A
Authority: CN
Inventors: 潘海英
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-23
Filing date: 2016-06-23
Publication date: 2016-09-07

Abstract

The invention provides a medicinal composition for treating cough and a preparation method thereof. The medicinal composition is prepared from the following raw materials: 3-5 parts of preserved averrhoa carambola, 2-4 parts of pericarpium citri reticulatae, 2-4 parts of preserved fructus mume, 7-10 parts of the root of aster, 1-3 parts of the fruit of schisandra chinensis, 2-4 parts of cinnamomum cassia, 4-6 parts of herba ephedrae, 3-5 parts of apricot, 4-6 parts of rhizoma zingiberis, 5-8 parts of liquorice root, 2-4 parts of shaved cinnamon bark, 1-4 parts of cassia bark, 1-3 parts of the fruit of gleditsia sinensis, 1-3 parts of the root of lilac daphne, 2-6 parts of fragrant fermented soy beans, 3-5 parts of radix bupleuri, 3-6 parts of muskmelon pedicel, 3-5 parts of the root or whole grass of pollia japonica, 1-3 parts of radix ginseng, 1-3 parts of rheum officinale, 2-4 parts of radix angelica sinensis and 3-5 parts of herba aristolochiae. The preparation method comprises the steps of extracting, concentrating, smashing and granulating to obtain the medicinal composition for treating cough. The medicinal composition has the effect of rapidly curing cough, and has the characteristics of scientific prescription, simple preparation method, low processing cost, remarkable curative effect and no toxic and side effects.

Description

A kind of pharmaceutical composition treating cough and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating cough and Its preparation method.

Background technology

Cough is one of modal symptom in respiratory system, when human body is by outer heresy, it is intended to depend on The mode outer evil a surname sent out by self strength, this is the task that lungs undertake, and just leans on It it is the ability that is sent to of a surname that lung itself has.The traditional Chinese medical science thinks that cough is because of the diseases caused by external factors six external factors which cause diseases, dirty Internal organs internal injury, affects in the card having phlegm sound caused by lung.See " Plain Questions the five internal organs generate a piece "." element Ask that interpretation of the cause, onset and process of an illness gas is preferably saved one's life collection ": " cough meaning sound without phlegm, lung qi hinder and unclear also；Coughing is nothing Sound and have phlegm, spleen wet dynamic and be phlegm also.Cough meaning has phlegm and sound, and lid moves in lung qi due to wound Wet in spleen, cough and for coughing also ".Cough is divided into exogenous cough and endogenous cough, divides by disease and evil, Have cough due to common cold, cough due to wind-cold evil, cough due to dryness, cough caused by dryness-heat, phlegmatic cough, anemopyretic cough, Heat is coughed, pestilent cough, cold cough, wet cough, heat are coughed, fire is coughed, eat and cough；Divide by internal organs qi and blood, Have the deficiency syndrome of the lung to cough, lung is coughed, the heart is coughed, cough due to the disorder of the Liver Channel, cough related to the spleen channel, kidney are coughed, cough with eccopresis, small intestine cough, stomach Cough, cough with incontirence of urine, triple energizer cough, cough with vomiting of bile, labor are coughed, gas is coughed, hemostasis is coughed；By cough morbidity Time divides with feature, have chronic cough, cough before dawn, nocturnal cough, dry cough, sip cough, cough accompanied by hoarseness, Cough.

Doctor trained in Western medicine thinks that cough is infected, by various viruses, bacterium and other microorganisms, the breathing caused Road infects, if more than localized infection is the most pharyngeal more than annular cartilage, it is simply that the upper respiratory tract Infect, if it is below the most pharyngeal that infection is developed to below annular cartilage, it is simply that lower respiratory tract sense Dye, it is simply that tracheae, bronchus, capillary bronchus, alveolar, interstitial lung infects.Whole exhale Inhaling road all can suffer the invasion and attack of various foeign element that pathological change occurs, these foeign elements, It is the most merely virus, bacterium, it is also possible to be various microorganisms, it is also possible to be various physics and chemistry Factor, environmental factor etc., or owing to virus, bacterium and various factors cause respiratory tract The pathology that mucous membrane occurs, it is impossible to improve along with virus, bacterium and the extinction of various microorganism, Cause the damage of respiratory mucosa self function, be the formation of the prolonged cough do not healed.Therefore, Even if here it is use the most senior antibiotic to be also difficult to the crux for the treatment of cough, it is necessary to improve The function of respiratory mucosa itself.Cough could be effected a radical cure.

For the treatment of cough, doctor trained in Western medicine uses relieving cough and asthma class medicine and antibiosis mostly clinically Element combination, reaches the purpose for the treatment of, but has the biggest side effect, and Chinese traditional treatment is coughed Prescription various, the specific aim of each prescription is different, and the decoction of traditional Chinese herbal decoction and taking All being inconvenient for, decocting time brings the biggest impact, therefore with taking improper meeting to treatment Needing one can either effectively treat cough, the medicine can conveniently taken again is to solve patient Problem.

Summary of the invention

In order to overcome above-mentioned prior art defect, it is an object of the invention to provide a kind for the treatment of Pharmaceutical composition of cough and preparation method thereof.

In order to solve above-mentioned technical problem, the present invention takes following technical scheme:

A kind of pharmaceutical composition treating cough, its weight composition includes: carambola dried meat 3～5 parts, Dried orange peel 2～4 parts, dark plum dried meat 2～4 parts, aster 7～10 parts, the fruit of Chinese magnoliavine 1～3 parts, Chinese cassia tree 2～4 Part, Chinese ephedra 4～6 parts, almond 3～5 parts, rhizoma zingiberis 4～6 parts, Radix Glycyrrhizae 5～8 parts, the osmanthus heart 2～4 Part, cassia bark 1～4 parts, Chinese honey locust 1～3 parts, root of lilac daphne 1～3 parts, fragrant fermented soya beans, salted or other wise 2～6 parts, 3～5 parts, Muskmelon pedicel 3～6 parts, wild ginger 3～5 parts, ginseng 1～3 parts, rheum officinale 1～3 parts, herba aristolochiae 3～5 parts.

Further, described pharmaceutical composition also includes: Radix Angelicae Sinensis 2～4 parts.

Further, optimum weight part of described pharmaceutical composition consists of: carambola dried meat 3 Part, dried orange peel 4 parts, 2 parts of dark plum dried meat, aster 10 parts, 2 parts of the fruit of Chinese magnoliavine, Chinese cassia tree 3 parts, fiber crops Huang 4 parts, 5 parts of almond, rhizoma zingiberis 6 parts, 7 parts of Radix Glycyrrhizae, 4 parts of the osmanthus heart, 3 parts of cassia bark, Chinese honey locust 2 parts, root of lilac daphne 1 part, fragrant fermented soya beans, salted or other wise 2 parts, radix bupleuri 3 parts, muskmelon pedicel 4 parts, wild ginger 5 parts, ginseng 2 parts, rheum officinale 3 parts, herba aristolochiae 4 parts, Radix Angelicae Sinensis 3 parts.

Wherein, the primarily serving the purpose of of above-mentioned constituent:

The sweet acid of carambola dried meat taste, cool in nature, nontoxic；Can heat-clearing, promote the production of body fluid, Li Shui, removing toxic substances；Control Cough due to wind-heat evil, polydipsia, aphthous stomatitis, toothache, urolithiasis.

The acid of dark plum dried meat taste, property are put down, and return liver, spleen, lung, kidney, stomach, large intestine channel, astringe the lung Cough-relieving, relieving diarrhea with astringents, stop blooding, promote the production of body fluid, the effect of claming ascaris, cure mainly chronic cough, dysphoria thirsty, for a long time Malaria, rush down for a long time, dysentery, have blood in stool, hematuria, metrorrhagia, the ascariasis of biliary tract stomachache, vomiting, hookworm disease.

Dried orange peel temperature, bitter are pungent, nontoxic；The main inverse gas of the heat of lump in the abdomen in the heart, Li Shuigu, for a long time clothes go The logical god of gas smelly, lower；Entering the heart channel of Hand-Shaoyin, lung meridian, smell rises more than fall, and sun is also； In the heart lung point also, lung governing qi, gas Chang Zeshun, gas becomes the most stagnant, stagnant then all tangible blood Food sputum, the most false stagnant gas forms lump in the abdomen, and lump in the abdomen becomes, and lung qi does not drops and here heat gives birth to；The pungent energy of dried orange peel dissipate, Hardship can be let out, and can break lump in the abdomen heat-clearing also；Toil sending down abnormally ascending, again main inverse gas, diet enters stomach, dissipates essence In liver, warm pungent evacuation, liver can dissipate essence, water paddy under also；The main fall of lung, lets out under toil, then The order of lung gold row decline, and the gas that lower empyreuma is turbid, rising of having no way of, thus deodorize and lower gas also； The heart is monarch, and here gods go out, and bitter clears away heart-fire, and the pungent energy of taste leads to, so logical god is also.

Aster bitter, warm in nature, nontoxic, can dissolving phlegm quench the thirst, moistening lung to lower qi, cough blood labor for phlegm Panacea, cough the miracle of vomiting of pus and blood.

The fruit of Chinese magnoliavine, taste acid, temperature, fall is also；Micro-sun in the moon, in non-sun, micro-the moon is also, nontoxic. Can add kidney-nourishing water, nourishing lung gold, outstanding kind moisturize, non-special convergence lung qi；Relieving restlessness is quenched the thirst life Tianjin, qi-restoratives benefit gas reinforcing yin essence；Cholera is rushed down profit and can be stopped, and oedema abdominal distension can disappear.

Chinese cassia tree, taste is pungent, sweet, fragrant, peppery, the big heat of gas, heavy also, enter kidney, spleen, bladder, Heart born of the same parents, Liver Channel；Supporting spirit, and color, Xing Yangnai is old, and hard joint, promoting blood circulation, under treatment The burnt cold of insufficiency type, control the autumn and winter suffer from abdominal pain, have loose bowels, to globefish, dredging water passages, warm muscle warms up dirty, and broken blood stimulates the menstrual flow, Middle regulating and qi tonifying, protects battalion in fact, and peace tells inverse pain.

Chinese ephedra, taste is sweet, pungent, and gas is trembled with fear, and floats the most clearly, rises also, and sun is also, nontoxic.Start with Meridian of Foot-TAI YANG, the lunar herbal classic of hand, Yangming Channel.The medicine of Rong Wei, and enter meridian of Foot-TAI YANG, hand Shaoyin channel is also.Inducing sweat and dispelling exogenous evils, dispels the wind and dissipates heresy, warm disease between the reason spring, the red pain of the blackspot that disappears, honor of dispelling Cold, except heart heat is had a headache, Zhi Xiaqiu trembles with fear epidemic disease.

Almond, taste is sweet, bitter, and temperature can rise and can drop, and cloudy middle-jiao yang, function of the spleen and stomach also, specially enters lunar lung channel； Being the agent under profit, remove dyspnea due to adverseness of QI in the heart, cough-relieving is coughed, and falls phlegm, moistens large intestine, gas-tight just difficult, By numbness dissipating bind.

Rhizoma zingiberis taste is pungent, warm in nature, enters stomach of foot Yang Ming, spleen of Foot-Taiyin, liver meridian, hand lunar Lung channel；Fullness sensation in chest cough with dyspnea, stops blooding in temperature, perspires, by wind, arthritis with fixed pain caused by dampness, intestines, lower profit, In eliminating dampness temperature, row strongly fragrant fall turbid, help fire soil, diet of dissolving, warming spleen and stomach and temperature brothers, adjust Vomiting depending on negative and positive, the inverse and flat cough of undershoot, proposes detrapping and on-slip is let out.

Radix Glycyrrhizae, taste is sweet, gas is flat, warm in nature, can rise and can drop, and sun middle-jiao yang, function of the spleen and stomach is also, nontoxic；Enter too Cloudy, the warp of the moon of fainting cloudy, few.The medicine of benefit is attacked in energy mediation, and outstanding being apt to stops all pains, except the deficiency of Yin intimately, Slake thirst and help produce saliva；But its property is delayed again, and all acute diseases the most preferably use it, the burnt vigour of upper, middle and lower three can be mended, With all urgency of medicine solution, its heat slow of medicine of a warm nature use, cold medicinal slow its is trembled with fear.Yang-tonifying is not enough, greatly There is outstanding service；The benefit that nourishes blood stomach, body reality good recipe；Can gas, hard muscle in evil removing pharyngalgia hot, sharp, reason Bone, long muscle, qualcomm meridian, profit vim and vigour, cough-relieving are coughed, moistening lung road.

Root of lilac daphne taste is pungent, bitter, and property is put down；Return lung, spleen, kidney channel.Main cough with dyspnea, laryngeal stridor Breathing heavily, pharynx is swollen loses heart, ghost malaria, hernia lump in the abdomen, and carbuncle swells.

Fragrant fermented soya beans, salted or other wise bitter, sweet, it is slightly cold, enters the spleen channel of foot-Taiyin.Mediation internal organs, the turbid stasis of blood of emetic therapy； Gas in being in harmonious proportion, rushes down the wet row stasis of blood, and cleaning loses turbid.

Radix bupleuri cold nature, bitter, pungent, return Liver Channel, gallbladder channel, tool soothing liver-gallbladder, dredge gas solution Effect of fire strongly fragrant, scattered；Tying gas in main trusted subordinate's stomach, diet gathers, and fever and chills perverse trend pushes away old Cause new.For a long time clothes make light of one's life by commiting suicide, improving eyesight, benefit essence.Clearind deficient heat Chinese medicine, for cold, fever, fever and chills Contact, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterus come off, irregular menstruation.

Muskmelon pedicel bitter, cold in nature, enter spleen, stomach lunar through, hand, foot bright, the Taiyin channels of sun, can Telling wind phlegm place food, water pouring is wet stops drink；Controlling sputum place food, be jammed Shangwan, in the heart ruffian stalk, wind Phlegm epilepsy, jaundice with damp-heat pathogen, four limbs edema, nasal obstruction, larynx numbness.

Wild ginger taste is pungent, warm in nature, nontoxic, returns lung, liver, kidney, bladder warp, can dissipate wind by cold, Dissolving phlegm row water, invigorates blood circulation, relievings asthma, analgesic therapy.Controlling anemofrigid cold, phlegm and retained fluid is breathed with cough, oedema, wind Wet, traumatic injury, headache, caries pain, eruptive disease is suffered from abdominal pain.

Ginseng is flat, taste hardship sweet, micro-, tepor.Return spleen, lung channel, the heart channel of Hang-Shaoyin；Can big complement Gas, multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid to quench thirst, intelligence development of calming the nerves；Cure mainly internal lesion caused by overexertion deficient, Food is less, food is told in burnout, gastric disorder causing nausea, stool lingering diarrhea, void cough that syndrome characterized by dyspnea, spontaneous perspiration are cruelly de-, palpitate with fear, Forgetful, dizziness and headache, impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's frightened slowly and empty for a long time Not multiple, the disease of all qi-blood-body fluid deficiencies.

Rheum officinale bitter, cold in nature, return stomach warp, large intestine channel, Liver Channel, the spleen channel, have purge heat logical Intestines, removing pattogenic heat from the blood and toxic material from the body, the effect stimulated the menstrual flow by the stasis of blood.

Herba aristolochiae bitter, warm in nature；Return liver,spleen,kidney warp；Can the promoting flow of qi and blood circulation, inducing diuresis for removing edema, Removing toxic substances；Have clearing lung-heat sending down abnormally ascending, the effect that relieving cough and asthma, gut purge disappears hemorrhoid.

Further, the primarily serving the purpose of of above-mentioned adding ingredient:

Radix Angelicae Sinensis taste is sweet, pungent, bitter, warm in nature；Return liver；The heart；The spleen channel；Can enrich blood, invigorate blood circulation, Menstruction regulating and pain relieving, moisturize laxation.Side utilize the function that Radix Angelicae Sinensis nourishes, regulation patient body put down Weighing apparatus, promotes patient's physique, also functions to the effect of nourishing while curing the disease.

The preparation method step of the present invention is as follows:

The first step, Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, root of lilac daphne, fragrant fermented soya beans, salted or other wise, bavin Recklessly, with alcohol extract, extract after muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, herba aristolochiae mixing Standby；

Second step, adds cellulase after the fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, Radix Glycyrrhizae mixing Extracting with water, filter after extract inactivation, filtrate is standby；

3rd step, the extract first step, second step obtained merges, is dried to obtain medicine The dry cream of extract solid；

4th step, extracts carambola dried meat, dried orange peel, dark plum dried meat, almond with the medicine of the 3rd step Thing solid is size-reduced, adds auxiliary material, pelletizes, makes required formulation.

Further, in the first step, described Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, Root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, the mixing of herba aristolochiae medicinal material Thing pulverized 40 mesh sieves, was the most slightly unfavorable for active ingredient dissolution, and meticulous medicine is just in the process of extraction In easily conglomeration, be unfavorable for filtering.

Further, in the first step, described Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, Root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, herba aristolochiae are mixed Extracting mode is: medicinal material mixture add 8～the 80 of 13 times～95% ethanol at the bar of 65～85 DEG C Extract 6～8 hours under part.

Further, in second step, the described fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, sweet Extracting mode after grass mixing adds cellulase is: medicinal material mixture adds 15～20 times pure Water under conditions of 44～49 DEG C 4～6 hours.

Further, the addition of described cellulase be the fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, Ginseng, the 0.08 of Radix Glycyrrhizae gross weight～0.1%.

Further, in second step, the method for described inactivation is for being warmed up to 94～97 DEG C Heat 2～3 hours.

Further, in the third step, the mode that described extract is dried is: vacuum drying, Vacuum freeze drying, spray drying, constant-pressure and high-temperature are dried.

Further, in the 4th step, the particle diameter after described drug extract solid is pulverized is little In 20 μm.

Further, in the 4th step, the formulation of described pharmaceutical composition is tablet, capsule Agent, granule, soft capsule.

The invention have the advantage that

The pharmaceutical composition for the treatment of cough disclosed by the invention, from motherland's medical treasure-house, presses According to traditional Chinese medical science prescription theory, skim the cream off milk, reconfigure so that it is drug-specific is for cough Shape works, side's middle-jiao yang, function of the spleen and stomach preserved peach, dried orange peel, dark plum dried meat, almond be medicine be also food, Medical value height is also easy to absorb simultaneously, and in the present invention, dry carambola is directly pulverized and is used as medicine, Remain composition of raw material to greatest extent, improve prepared pharmaceutical composition for coughing The result for the treatment of coughed, while playing treatment cough effect, improves patient's physique；In conjunction with Modern biotechnology pharmaceutical technology, preparation method is simple, processing cost is low, evident in efficacy, made The standby medicine efficacy of a drug is strong, instant effect, can eliminate rapidly cough symptom, conveniently take.

Detailed description of the invention

The specific embodiment of the present invention given below, is used for making the present invention the most specifically Bright.

Experimental technique in following embodiment, if no special instructions, is conventional method.Under State in embodiment medicinal raw material used, reagent material etc., if no special instructions, be city Sell purchase product.

Embodiment 1

A kind of pharmaceutical composition treating cough

Bulk drug forms: (unit: g)

Carambola dried meat 300, dried orange peel 200, dark plum dried meat 200, aster 700, the fruit of Chinese magnoliavine 100, Chinese cassia tree 200, Chinese ephedra 400, almond 300, rhizoma zingiberis 400, Radix Glycyrrhizae 500, the osmanthus heart 200, cassia bark 100, Chinese honey locust 100, root of lilac daphne 100, fragrant fermented soya beans, salted or other wise 200, radix bupleuri 300, muskmelon pedicel 300, wild ginger 300, people Ginseng 100, rheum officinale 100, herba aristolochiae 300, Radix Angelicae Sinensis 200.

It is prepared via a method which:

(1) take Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, Muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, herba aristolochiae mix the ethanol of add 26.4kg 80% at 85 DEG C Under conditions of extract 8 hours, filter, filtrate is standby.

(2) take the fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, Radix Glycyrrhizae mixing add the pure of 19.5kg Water and cellulase 1.04g extract 6 hours under conditions of 44 DEG C.

(3) temperature being warmed up to 94 DEG C of heating inactivation in 3 hours, filters, filtrate is standby.

(4) take (1), the filtrate of (2) merges, and is 43kPa at dry pressure, and temperature is Under the conditions of 75 DEG C, filtrate is dried to the drug extract solid of 690g.

(5) by the solid in carambola dried meat, dried orange peel, dark plum dried meat, almond same (4) at normal pressure Under conditions of 70 DEG C, forced air drying is through ultramicro grinding, obtains the particle diameter medicine less than 20 μm Composition powder 1690g；According to drug powder: starch: the ratio of sucrose=13:6:5 adds Starch 780g, sucrose 650g, mix, and pelletizes, makes granule, packing, every bag 5g, there are granule 624 bags.

Embodiment 2

A kind of pharmaceutical composition treating cough

Bulk drug forms: (unit: g)

Carambola dried meat 500, dried orange peel 400, dark plum dried meat 400, aster 1000, the fruit of Chinese magnoliavine 300, meat Osmanthus 400, Chinese ephedra 600, almond 500, rhizoma zingiberis 600, Radix Glycyrrhizae 800, the osmanthus heart 400, cassia bark 400, Chinese honey locust 300, root of lilac daphne 300, fragrant fermented soya beans, salted or other wise 600, radix bupleuri 500, muskmelon pedicel 600, wild ginger 500, people Ginseng 300, rheum officinale 300, herba aristolochiae 500, Radix Angelicae Sinensis 400.

It is prepared via a method which:

(1) take Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, Muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, herba aristolochiae mix the ethanol of add 83.2kg 95% at 65 DEG C Under conditions of extract 6 hours, filter, filtrate is standby.

(2) take the fruit of Chinese magnoliavine, Chinese cassia tree, ginseng, rhizoma zingiberis, Radix Glycyrrhizae mixing add the pure of 48kg Water and cellulase 2.4g extract 4 hours under conditions of 49 DEG C.

(3) temperature being warmed up to 97 DEG C of heating inactivation in 2 hours, filters, filtrate is standby.

(4) take (1), the filtrate of (2) merges, at pre-freezing temperature-45 DEG C, freeze-off time 7h；Lyophilization mode for directly shelf temperature is set as 40 DEG C, circulation pipe in the middle part of cold-trap Temperature is set as-46 DEG C, and filtrate freeze-drying is processed under conditions of 7h by drying time；? Packaging operation ambient humidity 20%, the solid under conditions of temperature 25 DEG C, freeze-drying obtained Packaging, prevents moisture regain from obtaining extract solid 1.32kg.

(5) by the solid in carambola dried meat, dried orange peel, dark plum dried meat, almond same (4) at normal pressure Under conditions of 70 DEG C, forced air drying is through pulverizing, and obtains the particle diameter drug regimen less than 40 μm Thing powder 3120g；Add 75% appropriate amount of ethanol, pelletize, dry 1.5 hours with the temperature of 80 DEG C, After drying medicinal mixture powder is processed through tabletting machine, every 400mg, obtain Medicine 7800.

Embodiment 3

A kind of pharmaceutical composition treating cough

Bulk drug forms: (unit: kg)

Carambola dried meat 4, dried orange peel 3, dark plum dried meat 3, aster 8.5, the fruit of Chinese magnoliavine 2, Chinese cassia tree 3, Chinese ephedra 5, Almond 4, rhizoma zingiberis 5, Radix Glycyrrhizae 6.5, the osmanthus heart 3, cassia bark 2.5, Chinese honey locust 2, root of lilac daphne 2, fragrant fermented soya beans, salted or other wise 4, radix bupleuri 4, muskmelon pedicel 4.5, wild ginger 4, ginseng 2, rheum officinale 2, herba aristolochiae 4, Radix Angelicae Sinensis 3.

It is prepared via a method which:

(1) take Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, Muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, herba aristolochiae mix the ethanol of add 485kg 90% at 75 DEG C Under conditions of extract 7 hours, filter, filtrate is standby.

(2) take the fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, Radix Glycyrrhizae mixing add the pure of 330kg Water and cellulase 16.5g extract 5 hours under conditions of 46 DEG C.

(3) temperature being warmed up to 96 DEG C of heating inactivation in 2.5 hours, filters, filtrate is standby.

(4) take (1), the filtrate of (2) merges, dried filtrate under the conditions of normal pressure 95 DEG C Obtain extract solid 10.05kg.

(5) by the solid in carambola dried meat, dried orange peel, dark plum dried meat, almond same (4) at normal pressure Under conditions of 70 DEG C, forced air drying is through pulverizing, and obtains the particle diameter drug regimen less than 40 μm Thing powder 24.05kg；Adding 70% appropriate amount of ethanol, after mixing thoroughly, the temperature with 60 DEG C is dried 1 hour, Pelletize, dry 1.5 hours with the temperature of 70 DEG C, after drying by medicinal powder mixture powder through pelletizing The encapsulated process of machine, every encapsulated 400mg, obtain capsule 60125.

Embodiment 4

A kind of pharmaceutical composition treating cough

Bulk drug forms: (unit: kg)

Carambola dried meat 3, dried orange peel 4, dark plum dried meat 2, aster 10, the fruit of Chinese magnoliavine 2, Chinese cassia tree 3, Chinese ephedra 4, Almond 5, rhizoma zingiberis 6, Radix Glycyrrhizae 7, the osmanthus heart 4, cassia bark 3, Chinese honey locust 2, root of lilac daphne 1, fragrant fermented soya beans, salted or other wise 2, Radix bupleuri 3, muskmelon pedicel 4, wild ginger 5, ginseng 2, rheum officinale 3, herba aristolochiae 4, Radix Angelicae Sinensis 3.

It is prepared via a method which:

(1) take Chinese ephedra, aster, Gui Xin, cassia bark, Chinese honey locust, root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, Muskmelon pedicel, wild ginger, rheum officinale, Radix Angelicae Sinensis, herba aristolochiae mix the ethanol of add 520kg 85% at 77 DEG C Under conditions of extract 7.5 hours, filter, filtrate is standby.

(2) take the fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, Radix Glycyrrhizae mixing add the pure of 350kg Water and cellulase 17g extract 4.5 hours under conditions of 45 DEG C.

(3) temperature being warmed up to 95 DEG C of heating inactivation in 2 hours, filters, filtrate is standby.

(4) take (1), the filtrate of (2) merges, at EAT 200 DEG C, pan feeding flow It is spray-dried when 60mL/min, shower nozzle rotating speed 25000r/min and obtains drug powder 9.6kg.

(5) by the solid in carambola dried meat, dried orange peel, dark plum dried meat, almond same (4) at normal pressure Under conditions of 70 DEG C, forced air drying is through ultramicro grinding, obtains the particle diameter medicine less than 25 μm Composition powder 23.6kg；Addition beeswax, HPO, soybean lecithin are sufficiently stirred for, Mix, stand, vacuumize, treat that in liquid, bubble is removed substantially, with the glue changed Hydraulic pressure ball, every dress 400mg compacting, obtain capsule 90000.

Experimental example 1

The animal acute toxicity test of the Chinese medicine composition of the present invention

The present embodiment 2 mensuration by Mouse oral administration medicine median lethal dose, investigates The Chinese medicine composition of embodiment 2 preparation is to the acute toxic reaction of mouse and death condition.

Take mouse 30, often group 10, divide 3 groups, the most high, medium and low 3 dosage groups (0.8, 0.4,0.2ml/15g) gastric infusion 3 times/day, it was predicted that the scope of Calculating Median Lethal Dose of Drugs.Knot Fruit display, high dose group does not measures median lethal dose, therefore by medicine gastric infusion median lethal The mensuration of amount changes the maximum doing under maximum volume and does the mensuration of some maximal tolerance dose.

Take mouse 30, on an empty stomach after 12 hours, with the selected 0.8ml/15g metering of prediction by Gastric infusion is to animal subject 3 times/day, Continuous Observation 7 days.

Giving by test product 24 hours in gavage, mouse spontaneous activity declines, and ingests, takes the photograph water and subtract Few；Within second day, spontaneous activity gradually tends to normal, stool, urine no abnormality seen, and mouse lives Dynamic, food ration, body weight growths, ight soil etc. are all normal, observe the rear test mice that expires whole Survival.

Observe and put to death whole test mice gross necropsy after expiring, find each important organ, as The heart, liver, spleen, lung, kidney, ovary, intestines, stomach etc. change without obvious pathomorphism.

The maximum dosage-feeding result of the test of medicine gastric infusion shows: 30 mouse are equal after being administered Without obvious toxic reaction, also without dead in one week.Record to after mouse stomach administration medicine Maximal tolerance dose is 47.2g/kg d, as become human oral dosage form 8.0g/60kg to calculate by clinic, Then the mouse of this medicine gavage maximal tolerance dose on the one is clinical adult oral dose on the one [(47.2g/kg) ÷ (8.0g/60kg) ≈ 354] times.Chinese traditional medicine composition of the present invention is described The security of thing is good.

Experimental example 2

The human trial of a kind of pharmaceutical composition treating cough of the present invention

Clinical data

One, general data: this Chinese medicine composition is applied to clinical observation case 100 example, man 67 examples, female 33 example.Age 30～70 years old.

Two, usage and dosage: during clinical practice, the component in composition according to the body weight of patient, Age and symptom take the circumstances into consideration increase and decrease.This Chinese medicine composition embodiment 1 medicine one day one bag.Take medicine Period less salt, low fat diet, wine of banning on opium-smoking and the opium trade, medication 15 days is 1 course for the treatment of.

Three, criterion of therapeutical effect:

(1) recovery from illness: cough symptom all disappears；

(2) take a turn for the better: cough symptom substantially alleviates；

(3) invalid: after 1 course for the treatment of of medication, cough symptom has no to disappear.

Four, result for the treatment of: (see table 1)

Table 1 treatment results

By drug therapy cough patients 100 example of the present invention, treat 1 course for the treatment of, wherein cure 92 examples, take a turn for the better 8 examples, and cure rate is 92%, and total effective rate is 100%.

These are only the preferred embodiments of the present invention and experimental example, be not limited to this Invention, for a person skilled in the art, the present invention can have various modifications and variations. All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement made Deng, should be included within the scope of the present invention.

Claims

1. the pharmaceutical composition treating cough, it is characterised in that including: carambola dried meat, old Skin, dark plum dried meat, aster, the fruit of Chinese magnoliavine, Chinese cassia tree, Chinese ephedra, almond, rhizoma zingiberis, Radix Glycyrrhizae, Gui Xin, cassia bark, Chinese honey locust, root of lilac daphne, fragrant fermented soya beans, salted or other wise, radix bupleuri, muskmelon pedicel, wild ginger, ginseng, Rheum officinale, herba aristolochiae, its weight portion consists of: carambola dried meat 3～5 parts, dried orange peel 2～4 parts, Dark plum dried meat 2～4 parts, aster 7～10 parts, the fruit of Chinese magnoliavine 1～3 parts, Chinese cassia tree 2～4 parts, fiber crops Yellow 4～6 parts, almond 3～5 parts, rhizoma zingiberis 4～6 parts, Radix Glycyrrhizae 5～8 parts, the osmanthus heart 2～4 parts, Cassia bark 1～4 parts, Chinese honey locust 1～3 parts, root of lilac daphne 1～3 parts, fragrant fermented soya beans, salted or other wise 2～6 parts, radix bupleuri 3～5 parts, muskmelon pedicel 3～6 parts, wild ginger 3～5 parts, ginseng 1～3 parts, rheum officinale 1～3 parts, Herba aristolochiae 3～5 parts.

Pharmaceutical composition the most according to claim 1, it is characterised in that also include: when Return 2～4 parts.

Pharmaceutical composition the most according to claim 2, it is characterised in that pharmaceutical composition Weight portion consists of: 3 parts of carambola dried meat, dried orange peel 4 parts, 2 parts of dark plum dried meat, aster 10 Part, 2 parts of the fruit of Chinese magnoliavine, Chinese cassia tree 3 parts, 4 parts of Chinese ephedra, 5 parts of almond, rhizoma zingiberis 6 parts, 7 parts of Radix Glycyrrhizae, 4 parts of the osmanthus heart, 3 parts of cassia bark, 2 parts of Chinese honey locust, root of lilac daphne 1 part, fragrant fermented soya beans, salted or other wise 2 parts, radix bupleuri 3 parts, muskmelon pedicel 4 parts, wild ginger 5 parts, ginseng 2 parts, rheum officinale 3 parts, Herba aristolochiae 4 parts, Radix Angelicae Sinensis 3 parts.

4. the preparation method of a pharmaceutical composition as claimed in claim 3, it is characterised in that Preparation method is as follows:

The first step, weigh Chinese ephedra 4～6 parts, aster 7～10 parts, the osmanthus heart 2～4 parts, osmanthus Skin 1～4 parts, Chinese honey locust 1～3 parts, root of lilac daphne 1～3 parts, fragrant fermented soya beans, salted or other wise 2～6 parts, radix bupleuri 3～5 Part, muskmelon pedicel 3～6 parts, wild ginger 3～5 parts, rheum officinale 1～3 parts, Radix Angelicae Sinensis 2～4 part, day Pulverize after celestial rattan 3～5 parts of mixing add 8 times～the 80% of 13 times～95% ethanol at 65 DEG C ～extract 6 hours～8 hours under conditions of 85 DEG C, filtering, extract is standby；

Second step, weigh the fruit of Chinese magnoliavine 1～3 parts, Chinese cassia tree 2～4 parts, rhizoma zingiberis 4～6 parts, The extraction of cellulase water, extract is added after ginseng 1～3 parts, Radix Glycyrrhizae 5～8 parts of mixing Filtering after inactivation, filtrate is standby；

3rd step, the extract first step, second step obtained merge, through vacuum It is dried, or vacuum freeze drying, or be spray-dried, or constant-pressure and high-temperature is dried, and obtains The dry cream of drug extract solid；

4th step, by carambola dried meat 3～5 parts, dried orange peel 2～4 parts, dark plum dried meat 2～4 parts, The drug extract solid prepared in almond 3～5 parts of same 3rd steps, through ultramicro grinding, adds Add auxiliary material, pelletize, make required tablet, or capsule, or granule, or Soft capsule.

Preparation method the most according to claim 4, it is characterised in that in the first step, The condition pulverized after the mixing of described medicinal material is: medicinal material mixture pulverized 40 mesh sieves.

Preparation method the most according to claim 4, it is characterised in that in second step, The described fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, Radix Glycyrrhizae mix carrying after adding cellulase The mode of taking is: medicinal material mixture adds the pure water of 15 times～20 times at 44 DEG C～49 DEG C Under the conditions of 4 hours～6 hours.

7. according to any one preparation method described in claim 4,6, it is characterised in that The addition of described cellulase is that the fruit of Chinese magnoliavine, Chinese cassia tree, rhizoma zingiberis, ginseng, Radix Glycyrrhizae are total The 0.08%～0.1% of weight.

Preparation method the most according to claim 4, it is characterised in that in second step, The method of described inactivation heats 2 hours～3 hours for being warmed up to 94 DEG C～97 DEG C.