CN105920557B - 肠灵胃舒片及其制备工艺 - Google Patents
肠灵胃舒片及其制备工艺 Download PDFInfo
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Abstract
本发明涉及一种内服药品,特别是肠灵胃舒片及其制备工艺。解决胃病和健胃的问题。肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪110~125g、党参112~130g、白术102~120g、茯苓100~118g、甘草112~130g、砂仁30~45g、白豆蔻30~48g、木香68~83g、白及73~88g、海螵蛸70~80g、黄芩71~87g、茵陈75~89g、大枣30~43g、干姜36~43g。采用如下步骤进行制备:①磨粉;②煎煮;③浓缩;④混合制备。严密组合,巧妙配伍,具有缓解治疗胃痛、恢复气力和调理肠胃的功效,从而使痛风得以控制,达到痊愈的目的。
Description
技术领域
本发明涉及一种内服药品,特别是肠灵胃舒片及其制备工艺。
背景技术
随着社会发展,人们生活和工作节奏也越来越快,为了工作或者学习等原因,人们不能按时吃饭,长久后易得胃病,现在胃病已成为当下都市生活的人们一种常见病症。市场上销售的胃药功能单一,生产工艺复杂,治标不治本,只是缓解胃肠病痛,治疗时间长,效果慢,增加患者的病痛时间。此外如何在治疗胃病同时,对胃进行保健,从而有益缓解患者病痛,也是本发明同样要考虑的问题之一。
肠胃病是俗称,为常见病多发病,总发病率约占人口的20%左右。年龄越大,发病率越高,特别是50岁以上的中老年人更为多见,男性高于女性,如不及时治疗,长期反复发作,极易转化为癌肿。胃肠病历来被医家视为疑难之症,一旦得病,需及时治疗、长期服药,才能控制或治愈。肠胃病的种类很多,包括:慢性肠炎、结肠炎、慢性胃炎(浅表性、糜烂性、萎缩性、反流性)、胃窦炎、胃溃疡、胃出血、胃穿孔、十二指肠溃疡等。
发明内容
本发明的目的在于针对现有技术的缺陷和不足,提供一种结构简单,设计合理、使用方便的一种胃肠药物,它采用较常见的配方料,通过不同的配方量组成,其制备工艺简单,治疗效果好,增加了人体免疫力和人体的胃肠蠕动,既能治疗胃病又具有健胃作用。
本发明解决其技术问题所采用的技术方案是:肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪110~125g、党参112~130g、白术102~120g、茯苓100~118g、甘草112~130g、砂仁30~45g、白豆蔻30~48g、木香68~83g、白及73~88g、海螵蛸70~80g、黄芩71~87g、茵陈75~89g、大枣30~43g、干姜36~43g。
更优的方案,该药物组合物的有效成分,由以下原料按重量比制成:黄芪115~120g、党参112~115g、白术110~115g、茯苓115~118g、甘草112~115g、砂仁35~40g、白豆蔻35~40g、木香75~80g、白及75~80g、海螵蛸75~80g、黄芩71~80g、茵陈75~80g、大枣35~40g、干姜36~40g。
所述肠灵胃舒片的制备方法,具体采用如下步骤:
①磨粉:取白术、砂仁、白豆蔻、木香4味药粉碎成细粉,备用;《中国药典》规定,“细粉”的定义为:能全部通过五号筛,并含能通过六号筛不少于95%的粉末;
②煎煮:黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次,10~12倍量水、2小时,8~10倍量水、1小时,8~10倍量水、1小时,每次煎煮后单独过滤。
③浓缩:合并滤液,浓缩至相对密度1.25~1.30(60~65℃)稠膏;减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥;
④混合制备:与上述①细粉混合,制粒,干燥,加入适量硬脂酸镁压制成1000片,即得。
黄芪,性甘温,归肺经,有补气升阳、益卫固表之功能。经常用黄芪配伍琼珍灵芝煎汤或泡水代茶饮,具有良好的防病保健作用。
白术,具有健脾益气,燥湿利水,止汗,安胎的功效,用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。
茯苓,味甘、淡,性平,归心、肺、脾、肾经,利水渗湿,健脾,宁心。
白豆蔻,味辛、性温,归肺、脾、胃经,功效化湿,行气,温中,止呕,临床用名白豆蔻。
木香,性味:辛味辛;苦;性温。①《本经》:味辛,温。②《汤液本草》:气热,味辛苦,无毒。归经:归脾;大肠、三焦经。
黄芩,根入药,味苦、性寒,有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。黄芩的临床抗菌性比黄连好,而且不产生抗药性。
茵陈,全草入药,性味归经:苦、辛,微寒。归脾、胃、肝、胆经。可预防流感,治中暑、感冒、头痛身重、腹痛、呕吐、胸膈胀满、气阻食滞、小儿食积腹胀、腹泻、月经过多、崩漏带下、皮肤瘙痒及水肿等症,其散热发表功用,尤胜于薄荷。
以上诸药,严密组合,巧妙配伍,具有缓解治疗胃痛、恢复气力和调理肠胃的功效,从而使痛风得以控制,达到痊愈的目的。
本发明具有以下有益效果:1、主治功能:脾胃气虚,倦怠乏力,嗳气,胸闷,脘腹胀痛或疼痛,大便不实。2、治疗结果:治愈275例,治愈率91.6%,显效20例,显著率6%。有效5例,有效率1.6%。
采用煎煮法可有效提取植物类药材的有效成分,采用粉碎法可有效保留白术、砂仁、白豆蔻和木香等药材的有效成分;二者有效成分混合,可最大限度的发挥药材的功效。
采用片剂有以下主要优点:剂量准确,因病人近片服用,而片内药物均匀、含量差异小;质量稳定,因系固体剂型,且某些易氧化变质或潮解的药物,可借助包衣或包合作用加以保护,水分、光线、空气对其影响较小。
附图说明
图1为本发明的工艺流程图。
图2为本发明病人甲的诊断病历。
图3为本发明病人甲经实施例1临床治疗后的复诊结果。
图4为本发明病人乙的诊断病历。
图5为本发明病人乙经实施例2临床治疗后的复诊结果。
图6为本发明病人丙的诊断病历。
图7为本发明病人丙经实施例2临床治疗后的复诊结果。
图8为本发明病人丁的诊断病历。
图9为本发明病人丁经实施例3临床治疗后的复诊结果。
具体实施方式
实施例1
肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪115g、党参115g、白术115g、茯苓115g、甘草115g、砂仁38g、白豆蔻38g、木香77g、白及77g、海螵蛸77g、黄芩77g、茵陈77g、大枣38g、干姜38g。
如图1所示,上述肠灵胃舒片具体采用如下步骤进行制备:
①磨粉:取白术、砂仁、白豆蔻、木香4味药粉碎成细粉,备用;《中国药典》规定,“细粉”的定义为:能全部通过五号筛,并含能通过六号筛不少于95%的粉末;
②煎煮:黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次,10倍量水、2小时,8 倍量水、1小时,8 倍量水、1小时,每次煎煮后单独滤过。
③浓缩:合并滤液,浓缩至相对密度1.25~1.30(温度下60~65℃)稠膏;减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥;
④混合制备:与上述①细粉混合,制粒,干燥,加入适量硬脂酸镁压制成1000片,即得。
为证明本发明具有很好的疗效,列举典型病例如图2、3所示。
实施例2
肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪120g、党参115g、白术110g、茯苓118g、甘草112g、砂仁35g、白豆蔻40g、木香80g、白及75g、海螵蛸80g、黄芩71g、茵陈75g、大枣35g、干姜40g。
所述肠灵胃舒片的制备方法,具体采用如下步骤:
①磨粉:取白术、砂仁、白豆蔻、木香4味药粉碎成细粉,备用;《中国药典》规定,“细粉”的定义为:能全部通过五号筛,并含能通过六号筛不少于95%的粉末;
②煎煮:黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次,12倍量水、2小时,8 倍量水、1小时,9 倍量水、1小时,每次煎煮后单独滤过。
③浓缩:合并滤液,浓缩至相对密度1.25~1.30(温度下60~65℃)稠膏;减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥;
④混合制备:与上述①细粉混合,制粒,干燥,加入适量硬脂酸镁压制成1000片,即得。
为证明本发明具有很好的疗效,列举典型病例如图 4、5、6、7。
实施例3
肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪115g、党参112g、白术115g、茯苓115g、甘草112g、砂仁40g、白豆蔻35g、木香75g、白及80g、海螵蛸75g、黄芩80g、茵陈80g、大枣40g、干姜36g。
如图1所示,上述肠灵胃舒片具体采用如下步骤进行制备:
①磨粉:取白术、砂仁、白豆蔻、木香4味药粉碎成细粉,备用;《中国药典》规定,“细粉”的定义为:能全部通过五号筛,并含能通过六号筛不少于95%的粉末;
②煎煮:黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次,11倍量水、2小时,9 倍量水、1小时,9 倍量水、1小时,每次煎煮后单独滤过。
③浓缩:合并滤液,浓缩至相对密度1.25~1.30(温度下60~65℃)稠膏;减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥;
④混合制备:与上述①细粉混合,制粒,干燥,加入适量硬脂酸镁压制成1000片,即得。
为证明本发明具有很好的疗效,列举典型病例如图8、9所示。
Claims (2)
1.肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪110~125g、党参112~130g、白术102~120g、茯苓100~118g、甘草112~130g、砂仁30~45g、白豆蔻30~48g、木香68~83g、白及73~88g、海螵蛸70~80g、黄芩71~87g、茵陈75~89g、大枣30~43g、干姜36~43g;
具体采用如下步骤:
①磨粉:取白术、砂仁、白豆蔻、木香4味药粉碎成细粉,备用;
②煎煮:黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次,10~12倍量水、2小时,8~10倍量水、1小时,8~10倍量水、1小时,每次煎煮后单独过滤;
③浓缩:合并滤液,减压浓缩,使用抽真空的方式降低水的沸腾温度使水蒸发干燥,浓缩至相对密度1.25~1.30稠膏;
④混合制备:与上述①细粉混合,制粒,干燥,加入硬脂酸镁压制成1000片,即得肠灵胃舒片。
2.如权利要求1所述肠灵胃舒片,该药物组合物的有效成分,由以下原料按重量比制成:黄芪115~120g、党参112~115g、白术110~115g、茯苓115~118g、甘草112~115g、砂仁35~40g、白豆蔻35~40g、木香75~80g、白及75~80g、海螵蛸75~80g、黄芩71~80g、茵陈75~80g、大枣35~40g、干姜36~40g。
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