CN105920557B - 肠灵胃舒片及其制备工艺 - Google Patents
肠灵胃舒片及其制备工艺 Download PDFInfo
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Abstract
本发明涉及一种内服药品，特别是肠灵胃舒片及其制备工艺。解决胃病和健胃的问题。肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪110～125g、党参112～130g、白术102～120g、茯苓100～118g、甘草112～130g、砂仁30～45g、白豆蔻30～48g、木香68～83g、白及73～88g、海螵蛸70～80g、黄芩71～87g、茵陈75～89g、大枣30～43g、干姜36～43g。采用如下步骤进行制备：①磨粉；②煎煮；③浓缩；④混合制备。严密组合，巧妙配伍，具有缓解治疗胃痛、恢复气力和调理肠胃的功效，从而使痛风得以控制，达到痊愈的目的。
Description
技术领域
本发明涉及一种内服药品，特别是肠灵胃舒片及其制备工艺。
背景技术
随着社会发展，人们生活和工作节奏也越来越快，为了工作或者学习等原因，人们不能按时吃饭，长久后易得胃病，现在胃病已成为当下都市生活的人们一种常见病症。市场上销售的胃药功能单一，生产工艺复杂，治标不治本，只是缓解胃肠病痛，治疗时间长，效果慢，增加患者的病痛时间。此外如何在治疗胃病同时，对胃进行保健，从而有益缓解患者病痛，也是本发明同样要考虑的问题之一。
肠胃病是俗称,为常见病多发病，总发病率约占人口的20%左右。年龄越大，发病率越高，特别是50岁以上的中老年人更为多见，男性高于女性，如不及时治疗，长期反复发作，极易转化为癌肿。胃肠病历来被医家视为疑难之症，一旦得病，需及时治疗、长期服药，才能控制或治愈。肠胃病的种类很多，包括：慢性肠炎、结肠炎、慢性胃炎（浅表性、糜烂性、萎缩性、反流性）、胃窦炎、胃溃疡、胃出血、胃穿孔、十二指肠溃疡等。
发明内容
本发明的目的在于针对现有技术的缺陷和不足，提供一种结构简单，设计合理、使用方便的一种胃肠药物，它采用较常见的配方料，通过不同的配方量组成，其制备工艺简单，治疗效果好，增加了人体免疫力和人体的胃肠蠕动，既能治疗胃病又具有健胃作用。
本发明解决其技术问题所采用的技术方案是：肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪110～125g、党参112～130g、白术102～120g、茯苓100～118g、甘草112～130g、砂仁30～45g、白豆蔻30～48g、木香68～83g、白及73～88g、海螵蛸70～80g、黄芩71～87g、茵陈75～89g、大枣30～43g、干姜36～43g。
更优的方案，该药物组合物的有效成分，由以下原料按重量比制成：黄芪115～120g、党参112～115g、白术110～115g、茯苓115～118g、甘草112～115g、砂仁35～40g、白豆蔻35～40g、木香75～80g、白及75～80g、海螵蛸75～80g、黄芩71～80g、茵陈75～80g、大枣35～40g、干姜36～40g。
所述肠灵胃舒片的制备方法，具体采用如下步骤：
①磨粉：取白术、砂仁、白豆蔻、木香4味药粉碎成细粉，备用；《中国药典》规定，“细粉”的定义为：能全部通过五号筛，并含能通过六号筛不少于95％的粉末；
②煎煮：黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次，10～12倍量水、2小时，8～10倍量水、1小时，8～10倍量水、1小时，每次煎煮后单独过滤。
③浓缩：合并滤液，浓缩至相对密度1.25～1.30（60～65℃）稠膏；减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥；
④混合制备：与上述①细粉混合，制粒，干燥，加入适量硬脂酸镁压制成1000片，即得。
黄芪，性甘温，归肺经，有补气升阳、益卫固表之功能。经常用黄芪配伍琼珍灵芝煎汤或泡水代茶饮，具有良好的防病保健作用。
白术，具有健脾益气，燥湿利水，止汗，安胎的功效，用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
茯苓，味甘、淡，性平，归心、肺、脾、肾经，利水渗湿，健脾，宁心。
白豆蔻，味辛、性温，归肺、脾、胃经，功效化湿，行气，温中，止呕，临床用名白豆蔻。
木香，性味：辛味辛；苦；性温。①《本经》：味辛，温。②《汤液本草》：气热，味辛苦，无毒。归经：归脾；大肠、三焦经。
黄芩，根入药，味苦、性寒，有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。黄芩的临床抗菌性比黄连好，而且不产生抗药性。
茵陈，全草入药，性味归经：苦、辛，微寒。归脾、胃、肝、胆经。可预防流感，治中暑、感冒、头痛身重、腹痛、呕吐、胸膈胀满、气阻食滞、小儿食积腹胀、腹泻、月经过多、崩漏带下、皮肤瘙痒及水肿等症，其散热发表功用，尤胜于薄荷。
以上诸药，严密组合，巧妙配伍，具有缓解治疗胃痛、恢复气力和调理肠胃的功效，从而使痛风得以控制，达到痊愈的目的。
本发明具有以下有益效果：1、主治功能：脾胃气虚，倦怠乏力，嗳气，胸闷，脘腹胀痛或疼痛，大便不实。2、治疗结果：治愈275例，治愈率91.6%，显效20例，显著率6%。有效5例，有效率1.6%。
采用煎煮法可有效提取植物类药材的有效成分，采用粉碎法可有效保留白术、砂仁、白豆蔻和木香等药材的有效成分；二者有效成分混合，可最大限度的发挥药材的功效。
采用片剂有以下主要优点：剂量准确，因病人近片服用，而片内药物均匀、含量差异小；质量稳定，因系固体剂型，且某些易氧化变质或潮解的药物，可借助包衣或包合作用加以保护，水分、光线、空气对其影响较小。
附图说明
图1为本发明的工艺流程图。
图2为本发明病人甲的诊断病历。
图3为本发明病人甲经实施例1临床治疗后的复诊结果。
图4为本发明病人乙的诊断病历。
图5为本发明病人乙经实施例2临床治疗后的复诊结果。
图6为本发明病人丙的诊断病历。
图7为本发明病人丙经实施例2临床治疗后的复诊结果。
图8为本发明病人丁的诊断病历。
图9为本发明病人丁经实施例3临床治疗后的复诊结果。
具体实施方式
实施例1
肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪115g、党参115g、白术115g、茯苓115g、甘草115g、砂仁38g、白豆蔻38g、木香77g、白及77g、海螵蛸77g、黄芩77g、茵陈77g、大枣38g、干姜38g。
如图1所示，上述肠灵胃舒片具体采用如下步骤进行制备：
①磨粉：取白术、砂仁、白豆蔻、木香4味药粉碎成细粉，备用；《中国药典》规定，“细粉”的定义为：能全部通过五号筛，并含能通过六号筛不少于95％的粉末；
②煎煮：黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次，10倍量水、2小时，8 倍量水、1小时，8 倍量水、1小时，每次煎煮后单独滤过。
③浓缩：合并滤液，浓缩至相对密度1.25～1.30（温度下60～65℃）稠膏；减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥；
④混合制备：与上述①细粉混合，制粒，干燥，加入适量硬脂酸镁压制成1000片，即得。
为证明本发明具有很好的疗效，列举典型病例如图2、3所示。
实施例2
肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪120g、党参115g、白术110g、茯苓118g、甘草112g、砂仁35g、白豆蔻40g、木香80g、白及75g、海螵蛸80g、黄芩71g、茵陈75g、大枣35g、干姜40g。
所述肠灵胃舒片的制备方法，具体采用如下步骤：
①磨粉：取白术、砂仁、白豆蔻、木香4味药粉碎成细粉，备用；《中国药典》规定，“细粉”的定义为：能全部通过五号筛，并含能通过六号筛不少于95％的粉末；
②煎煮：黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次，12倍量水、2小时，8 倍量水、1小时，9 倍量水、1小时，每次煎煮后单独滤过。
③浓缩：合并滤液，浓缩至相对密度1.25～1.30（温度下60～65℃）稠膏；减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥；
④混合制备：与上述①细粉混合，制粒，干燥，加入适量硬脂酸镁压制成1000片，即得。
为证明本发明具有很好的疗效，列举典型病例如图 4、5、6、7。
实施例3
肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪115g、党参112g、白术115g、茯苓115g、甘草112g、砂仁40g、白豆蔻35g、木香75g、白及80g、海螵蛸75g、黄芩80g、茵陈80g、大枣40g、干姜36g。
如图1所示，上述肠灵胃舒片具体采用如下步骤进行制备：
①磨粉：取白术、砂仁、白豆蔻、木香4味药粉碎成细粉，备用；《中国药典》规定，“细粉”的定义为：能全部通过五号筛，并含能通过六号筛不少于95％的粉末；
②煎煮：黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次，11倍量水、2小时，9 倍量水、1小时，9 倍量水、1小时，每次煎煮后单独滤过。
③浓缩：合并滤液，浓缩至相对密度1.25～1.30（温度下60～65℃）稠膏；减压浓缩:使用抽真空的方式降低水的沸腾温度使水蒸发干燥；
④混合制备：与上述①细粉混合，制粒，干燥，加入适量硬脂酸镁压制成1000片，即得。
为证明本发明具有很好的疗效，列举典型病例如图8、9所示。
Claims (2)
1.肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪110～125g、党参112～130g、白术102～120g、茯苓100～118g、甘草112～130g、砂仁30～45g、白豆蔻30～48g、木香68～83g、白及73～88g、海螵蛸70～80g、黄芩71～87g、茵陈75～89g、大枣30～43g、干姜36～43g；
具体采用如下步骤：
①磨粉：取白术、砂仁、白豆蔻、木香4味药粉碎成细粉，备用；
②煎煮：黄芪、党参、茯苓、黄芩、白及、海螵蛸、茵陈、大枣、干姜和甘草10味药混合加水煎煮三次，10～12倍量水、2小时，8～10倍量水、1小时，8～10倍量水、1小时，每次煎煮后单独过滤；
③浓缩：合并滤液，减压浓缩，使用抽真空的方式降低水的沸腾温度使水蒸发干燥，浓缩至相对密度1.25～1.30稠膏；
④混合制备：与上述①细粉混合，制粒，干燥，加入硬脂酸镁压制成1000片，即得肠灵胃舒片。
2.如权利要求1所述肠灵胃舒片，该药物组合物的有效成分，由以下原料按重量比制成：黄芪115～120g、党参112～115g、白术110～115g、茯苓115～118g、甘草112～115g、砂仁35～40g、白豆蔻35～40g、木香75～80g、白及75～80g、海螵蛸75～80g、黄芩71～80g、茵陈75～80g、大枣35～40g、干姜36～40g。
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| CN103751739A (zh) * | 2013-12-30 | 2014-04-30 | 南京海思创新生物科技有限公司 | 治疗慢性胃炎的中药组合物、其在制备治疗慢性胃炎的药物中的应用及其制备方法 |
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| CN103751739A (zh) * | 2013-12-30 | 2014-04-30 | 南京海思创新生物科技有限公司 | 治疗慢性胃炎的中药组合物、其在制备治疗慢性胃炎的药物中的应用及其制备方法 |
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