CN109528943A - 一种抗流感中药高浓缩丸的配方及制备 - Google Patents

一种抗流感中药高浓缩丸的配方及制备 Download PDF

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CN109528943A
CN109528943A CN201910037696.8A CN201910037696A CN109528943A CN 109528943 A CN109528943 A CN 109528943A CN 201910037696 A CN201910037696 A CN 201910037696A CN 109528943 A CN109528943 A CN 109528943A
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谢文纬
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Abstract

本发明涉及一种抗流感中药高浓缩丸的配方，包括以下重量份数的成分：蒲公英9～10份，穿心莲9～10份，鱼腥草9～10份，板蓝根9～10份，葛根9～10份，生石膏9～10份，芦根9～10份，大青叶4～5份，连翘4～5份，黄芩4～5份，金银花2.5～3.5份，紫苏叶2.5～3.5份，柴胡2.5～3.5份，桂枝2.5～3.5份，杏仁2.5～3.5份，生甘草2.5～3.5份，桔梗2.5～3.5份，麻黄2～3份。本发明还涉及利用上述成分制备高浓缩丸的方法。通过使用本发明提供的方法制备出的高浓缩丸，具有清热解毒、散风驱邪的功效，且临床效果接近汤药的作用，且只需开水送服即可，不会有常服中药的苦涩口感，制备过程简单，可广泛应用在中药及其制备技术领域。

Description

一种抗流感中药高浓缩丸的配方及制备
技术领域
本发明涉及中药技术领域，具体是指一种抗流感中药高浓缩丸的配方；本发明还涉及中药的制备方法，具体是指一种抗流感中药高浓缩丸的制备方法。
背景技术
病毒性流感治疗不当可致人丧命，特别是当流感失控，疾病进入迅猛发展期，出现持续高热不退时，无论用西药，还是现有抗流感中成药都控制不住疾病。传统的中成药剂型有丸散膏丹，也有现代的胶囊、口服液、片剂等，虽然服用方便，但中药的实际含有量与临床运用的汤剂相差甚远，因此疗效远不及汤药，这也是目前中成药市场停滞的原因，但近年来在医院广泛推广的颗粒冲剂已经弥补其不足。中药颗粒冲剂基本都是在药厂预先加工好的浓缩粉并现场配制，所含中药量比常规的中药冲剂高十几倍，疗效也接近临床上汤药的效果，但由于其口味苦涩难咽，常不为病人接受。
发明内容
为解决上述技术问题，本发明提供的技术方案为：
一种抗流感中药高浓缩丸的配方，包括以下重量份数的成分：蒲公英9～10份，穿心莲9～10份，鱼腥草9～10份，板蓝根9～10份，葛根9～10份，生石膏9～10份，芦根9～10份，大青叶4～5份，连翘4～5份，黄芩4～5份，金银花2.5～3.5份，紫苏叶2.5～3.5份，柴胡2.5～3.5份，桂枝2.5～3.5份，杏仁2.5～3.5份，生甘草2.5～3.5份，桔梗2.5～3.5份，麻黄2～3份。
优选地，包括以下重量份数的成分：蒲公英9份，穿心莲9份，鱼腥草9份，板蓝根9份，葛根9份，生石膏9份，芦根9份，大青叶4.5份，连翘4.5份，黄芩4.5份，金银花3份，紫苏叶3份，柴胡3份，桂枝3份，杏仁3份，生甘草3份，桔梗3份，麻黄2.5份。
本发明还提供了一种技术方案：
一种抗流感中药高浓缩丸的制备方法，所述高浓缩丸采用上述所述的高浓缩丸的配方制作，在制备时，在制备时，分别取一定量的蒲公英、穿心莲、鱼腥草、板蓝根、葛根、生石膏、芦根、大青叶、连翘、黄芩、金银花、紫苏叶、柴胡、桂枝、杏仁、生甘草、桔梗和麻黄中药颗粒浓缩原粉充分混匀，并根据制备时的室温、空气湿度和粉末形态添加一定量的辅料；最后，用改制的旋转式压片机对添加辅料后的混合物进行压制，且密封保存，即为抗流感中药高浓缩丸。
优选地，所述辅料包括食品级麦芽糊精和硬脂酸镁。
优选地，所述食品级麦芽糊精在粉末形态为松散时使用，且所述食品级麦芽糊精占粉末总重的1-3％。
优选地，所述硬脂酸镁在当粉末状态为粘性时使用，且所述硬脂酸镁占粉末总重的0.2-1％。
采用以上成分以及制备方法后，本发明具有如下优点：
(1)上述成分制备成的高倍浓缩丸具有清热解毒、散风驱邪的功效，且临床效果接近汤药的作用；
(2)上述成分在服用时，只需开水送服即可，不会有常服中药的苦涩口感，从而使得一些对苦涩中药反感的患者也能欣然服用，利于在流感爆发时广泛施用，从而对疫情进行有效控制；
(3)本方法制备过程简单，利用加工制作，节省工艺成本，具有很大的市场推广前景和广泛的医药应用范围；
(4)本发明提供的制备方法也可用于其他中药配方或其他国家草本药方的制备，由于新中药剂型所含实际中药量远高于传统中药剂型，因此具有极高的医学应用价值，并有推进中成药疗效发展的革命性推进作用。
具体实施方式
下面对本发明做进一步的详细说明。
根据中医理论，本发明配方各个成分的药效如下：
蒲公英：性寒，味苦，适用于痈肿疔疮、湿热淋症以及黄疸，具有显著抗病毒作用；
穿心莲：清热解毒，清肺利咽，消炎，消肿止痛；
鱼腥草：清热解毒，利尿通淋，消炎及抗病毒作用；
板蓝根：清热解毒，有抗病毒及利咽之功效；
葛根：具有清热，舒展平滑肌、扩张血管、调节心肌代谢之功效；
生石膏：甘，辛，寒；清热泻火，除烦止渴；用于外感热病，高热烦渴，肺热咳喘，胃火亢盛，头痛，牙痛；
芦根：用于热病烦渴，胃热呕吐，肺热咳嗽，肺痈吐脓，热淋涩痛；
大青叶：清热解毒，凉血，及抗病毒作用；
连翘：清热解毒，消肿散结，清肺止咳，利咽；
黄芩：清热燥湿，泻火解毒，清肺肝之火；
金银花：清热解毒，主治温病发热、热毒血痢、痈疽疔毒等症；
紫苏叶：散风驱寒，发汗力强，用于风寒表症，包括恶寒、发热、无汗等症；
柴胡：用于感冒发热，寒热往来，疟疾，肝郁气滞，胸肋胀痛，月经不调；
桂枝：辛温，温经散寒，强心通脉，治感冒风寒、发热恶寒之表证；
杏仁：止咳润肺，宣肺降气；
生甘草：益气生津，清热解毒，和中利咽；
桔梗：止咳宣肺，治疗肺痈；
麻黄：辛，微苦，温，用于发汗解表，宣肺平喘，利水消肿，散寒降热。
实施例一
一种抗流感中药高浓缩丸的配方，包括以下重量份数的成分：蒲公英9份，穿心莲9份，鱼腥草9份，板蓝根9份，葛根9份，生石膏9份，芦根9份，大青叶4.5份，连翘4.5份，黄芩4.5份，金银花3份，紫苏叶3份，柴胡3份，桂枝3份，杏仁3份，生甘草3份，桔梗3份，麻黄2.5份。
其中：板蓝根在具体制备时选用市面上常用的各种品牌的颗粒状即可。
蒲公英选用其新鲜采摘下来的花朵并置于阴凉的地方晾干即可。
在进行制备时：
分别取一定量的蒲公英、穿心莲、鱼腥草、板蓝根、葛根、生石膏、芦根、大青叶、连翘、黄芩、金银花、紫苏叶、柴胡、桂枝、杏仁、生甘草、桔梗和麻黄中药颗粒充分混匀，并根据制备时的室温和粉末形态添加一定量的辅料；最后，用旋转式压片机对添加辅料后的混合物进行压制，且密封保存，即为抗流感中药高浓缩丸。
其中：食品级麦芽糊精在混合物形态为松散时使用，且食品级麦芽糊精占粉末总重的1-3％。
硬脂酸镁在当混合物状态为粘性时使用，且硬脂酸镁占粉末总重的0.2-1％。
实施例二
一种抗流感中药高浓缩丸的配方，包括以下重量份数的成分：蒲公英10份，穿心莲10份，鱼腥草10份，板蓝根10份，葛根10份，生石膏10份，芦根10份，大青叶5份，连翘5份，黄芩5份，金银花3.5份，紫苏叶3.5份，柴胡3.5份，桂枝3.5份，杏仁3.5份，生甘草3.5份，桔梗3.5份，麻黄3份。

Claims (6)

1.一种抗流感中药高浓缩丸的配方，其特征在于，包括以下重量份数的成分：蒲公英9～10份，穿心莲9～10份，鱼腥草9～10份，板蓝根9～10份，葛根9～10份，生石膏9～10份，芦根9～10份，大青叶4～5份，连翘4～5份，黄芩4～5份，金银花2.5～3.5份，紫苏叶2.5～3.5份，柴胡2.5～3.5份，桂枝2.5～3.5份，杏仁2.5～3.5份，生甘草2.5～3.5份，桔梗2.5～3.5份，麻黄2～3份。
2.根据权利要求1所述的一种抗流感中药高浓缩丸的配方，其特征在于，包括以下重量份数的成分：蒲公英9份，穿心莲9份，鱼腥草9份，板蓝根9份，葛根9份，生石膏9份，芦根9份，大青叶4.5份，连翘4.5份，黄芩4.5份，金银花3份，紫苏叶3份，柴胡3份，桂枝3份，杏仁3份，生甘草3份，桔梗3份，麻黄2.5份。
3.一种抗流感中药高浓缩丸的制备方法，其特征在于，所述高浓缩丸采用上述权利要求1所述的高浓缩丸的配方制作，在制备时，分别取一定量的蒲公英、穿心莲、鱼腥草、板蓝根、葛根、生石膏、芦根、大青叶、连翘、黄芩、金银花、紫苏叶、柴胡、桂枝、杏仁、生甘草、桔梗和麻黄中药颗粒浓缩原粉充分混匀，并根据制备时的室温、空气湿度和粉末形态添加一定量的辅料；最后，用改制的旋转式压片机对添加辅料后的混合物进行压制，且密封保存，即为抗流感中药高浓缩丸。
4.根据权利要求3所述的一种抗流感中药高浓缩丸的制备方法，其特征在于，所述辅料包括食品级麦芽糊精和硬脂酸镁。
5.根据权利要求4所述的一种抗流感中药高浓缩丸的制备方法，其特征在于，所述食品级麦芽糊精在粉末形态为松散时使用，且所述食品级麦芽糊精占粉末总重的1-3％。
6.根据权利要求4所述的一种抗流感中药高浓缩丸的制备方法，其特征在于，所述硬脂酸镁在当粉末状态为粘性时使用，且所述硬脂酸镁占粉末总重的0.2-1％。
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