CN105920526B - Millettia speciosa champ composition for regulating immunity and preparation method and application thereof - Google Patents
Millettia speciosa champ composition for regulating immunity and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention relates to the field of traditional Chinese medicines, and discloses a beautiful millettia root composition for regulating immunity and a preparation method and application thereof. The bovine powerful composition for regulating immunity comprises the following components in parts by weight: 30-60 parts of beautiful millettia root, 20-40 parts of lucid ganoderma, 10-40 parts of szechuan lovage rhizome, 10-30 parts of dwarf lilyturf tuber, 10-30 parts of aquilaria sinensis, 5-20 parts of turmeric, 5-20 parts of lotus seed and 5-20 parts of dendrobium officinale. The invention also discloses a preparation method of the composition. The beautiful millettia root composition for regulating immunity is used by matching the components, has the effects of nourishing the heart, soothing the nerves, regulating vital energy and promoting qi circulation, and can effectively improve physique and improve the resistance of organisms. The preparation method provided by the invention is simple and feasible, and can be used for large-scale production. The prepared medicinal preparation can effectively regulate the immunity of the organism and has obvious curative effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a beautiful millettia root composition for regulating immunity and a preparation method and application thereof.
Background
Beautiful millettia root is the root of Millettia speciosa which is a leguminous plant and is distributed in Fujian, Hunan, Guangdong, Guangxi, Yunnan, Guizhou and other places in China. It has sweet and fragrant smell, and has effects of tonifying yang, nourishing kidney, tonifying deficiency, strengthening tendons, and activating collaterals. The beautiful millettia root is used for treating symptoms such as lung deficiency cough, hemoptysis, cough with asthma, lumbar muscle strain, rheumatism paralysis and the like in folk, and clinical experience also proves that the beautiful millettia root is a traditional medicine and food homologous plant for rheumatoid arthritis and phthisis, and the beautiful millettia root has high nutritional value and medicinal value when being frequently used as food therapy and medicinal diet.
The immunity is a self defense mechanism of a human body and is the capability of resisting external invasion and maintaining the stability of the internal environment of the body. If the immunity is low, the body is easy to be infected or suffer from cancer, and the high immunity also has harmful results on the body, such as causing anaphylaxis, autoimmune diseases and the like. If the immune system of the body can not play a protective role normally, various infections are easily caused under the condition, so the most direct manifestation of low immunity is easy to get ill. When the human body is immune dysfunctional or the immune system is not healthy, the following problems are repeatedly caused: cold, asthma, tonsillitis, pneumonia, diarrhea, etc. And once ill, it usually takes a longer time to recover. In the past, the body consumption was increased, and serious diseases were also easily induced. And modern medical science finds that the hypoimmunity is one of the important reasons of aging. Therefore, regulating the function of the immune system and activating the function of the immune system of the body are one of the important means for keeping health.
Disclosure of Invention
The invention provides a beautiful millettia root composition for regulating immunity and a preparation method and application thereof.
The technical scheme of the invention is realized as follows:
the bovine powerful composition for regulating immunity comprises the following components in parts by weight: 30-60 parts of beautiful millettia root, 20-40 parts of lucid ganoderma, 10-40 parts of szechuan lovage rhizome, 10-30 parts of dwarf lilyturf tuber, 10-30 parts of aquilaria sinensis, 5-20 parts of turmeric, 5-20 parts of lotus seed and 5-20 parts of dendrobium officinale.
Further, the beautiful millettia root composition for regulating immunity comprises the following components in parts by weight: 40-50 parts of beautiful millettia root, 25-30 parts of lucid ganoderma, 20-30 parts of szechuan lovage rhizome, 15-25 parts of dwarf lilyturf tuber, 15-25 parts of aquilaria sinensis, 10-15 parts of turmeric, 10-15 parts of lotus seed and 10-15 parts of dendrobium officinale.
A medicine for regulating immunity is the ethanol extract of the beautiful millettia root composition.
The preparation method of the radix millettiae speciosae medicine for regulating immunity comprises the following steps: taking radix millettiae speciosae, lucid ganoderma, ligusticum wallichii, radix ophiopogonis, radix aristolochiae, turmeric, lotus seeds and dendrobium officinale according to the formula amount, cleaning, drying, adding ethanol, heating, refluxing and extracting, and filtering to remove dregs to obtain filtrate; repeatedly extracting for 2-3 times, and mixing the filtrates; and drying the filtrate under reduced pressure to obtain the composition for regulating the immunity.
Further, the temperature is controlled at 60-70 deg.C during the drying process, and the medicinal materials are pulverized to 20-30 mesh.
Furthermore, the volume concentration of the ethanol is 70-85%, and the mass of the added ethanol is 6-10 times of the total mass of the medicinal materials.
Further, the temperature is controlled to be 80-85 ℃ in the reflux process, and the temperature is controlled to be 40-50 ℃ in the decompression drying process.
The application of the beautiful millettia root composition for regulating immunity, the medicine for regulating immunity or the medicine for regulating immunity prepared by the preparation method in preparing a preparation with the function of regulating immunity.
A preparation for regulating immunity comprises the beautiful millettia root composition for regulating immunity, or a medicine for regulating immunity prepared by the preparation method.
The invention has the beneficial effects that:
the beautiful millettia root composition for regulating immunity is used by matching the components, so that on one hand, the beautiful millettia root composition can regulate the functions of the spleen and the stomach, strengthen the physique and improve the resistance of the organism to various diseases; on the other hand, the traditional Chinese medicine composition can regulate qi, promote qi circulation, guide air and reduce root causes, regulate the functions of the immune system of the organism, reduce excessive immune reaction and reduce the occurrence of anaphylactic reaction. In addition, the components for tonifying middle-jiao and Qi are added in the formula, so that the body constitution can be effectively improved, the functions of the immune system in the body can be activated, the body constitution of the body can be fundamentally improved, and the regulating capability of the immune system can be improved. The beautiful millettia root composition for regulating immunity disclosed by the invention has the effects of regulating qi, promoting qi circulation and guiding air to recover the origin, and regulating the intrinsic qi activity of an organism, so that the resistance of the organism can be improved, the occurrence of anaphylactic reaction can be reduced, and the effect of bidirectional regulation on immunity is achieved. The immunity of the organism is adjusted, and the self resistance of the organism is stimulated; the body constitution is improved, the resistance is increased, the self functions of the body can be effectively recovered, the exertion of the drug effect is facilitated, the drug effect is consolidated, and the repeated occurrence of various problems of an immune system is avoided. The medicinal materials in the formula are mutually promoted and depended to play a role together, so that on one hand, the immunity can be improved, the resistance to various diseases is enhanced, on the other hand, the excessive immune reaction can be regulated, the generation of anaphylactic reaction is reduced, and the effect of bidirectional regulation on the immunity is achieved.
The preparation method of the radix millettiae speciosae composition for regulating immunity is simple to operate, convenient to control conditions, stable in yield and capable of carrying out large-scale industrial production. The prepared medicinal preparation can effectively regulate the immunity of the organism and has obvious curative effect.
Detailed Description
The technical solutions in the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The bovine powerful composition for regulating immunity comprises the following components in parts by weight: 30g of beautiful millettia root, 20g of lucid ganoderma, 10g of szechuan lovage rhizome, 10g of dwarf lilyturf tuber, 10g of costus root, 5g of turmeric, 5g of lotus seed and 5g of dendrobium officinale.
A preparation method of a beautiful millettia root composition for regulating immunity comprises the following steps:
(1) taking beautiful millettia root, lucid ganoderma, szechuan lovage rhizome, dwarf lilyturf tuber, costus root, turmeric, lotus seed and dendrobium officinale according to the formula ratio, cleaning, drying at 60 ℃, and crushing to 20 meshes; adding 70% ethanol with a volume concentration of 6 times of the total mass of the medicinal materials, heating and reflux-extracting at 80 deg.C, and filtering to remove residue to obtain filtrate; extracting for 2 times, and mixing the filtrates;
(2) and (2) drying the filtrate obtained in the step (1) at 40 ℃ under reduced pressure to obtain the composition for regulating the immunity.
Example 2
The bovine powerful composition for regulating immunity comprises the following components in parts by weight: 60g of beautiful millettia root, 40g of lucid ganoderma, 30g of szechuan lovage rhizome, 30g of dwarf lilyturf tuber, 30g of costus root, 20g of turmeric, 20g of lotus seed and 20g of dendrobium officinale.
A preparation method of a beautiful millettia root composition for regulating immunity comprises the following steps:
(1) taking beautiful millettia root, lucid ganoderma, szechuan lovage rhizome, dwarf lilyturf tuber, costus root, turmeric, lotus seed and dendrobium officinale according to the formula ratio, cleaning, drying at 70 ℃, and crushing to 30 meshes; adding 85% ethanol with a volume concentration of 10 times of the total mass of the medicinal materials, heating and reflux-extracting at 85 deg.C, filtering to remove residue to obtain filtrate; extracting repeatedly for 3 times, and mixing the filtrates;
(2) and (2) drying the filtrate obtained in the step (1) at 50 ℃ under reduced pressure to obtain the composition for regulating the immunity.
Example 3
The bovine powerful composition for regulating immunity comprises the following components in parts by weight: 45g of beautiful millettia root, 30g of lucid ganoderma, 25g of szechuan lovage rhizome, 20g of dwarf lilyturf tuber, 20g of costus root, 12g of turmeric, 12g of lotus seed and 12g of dendrobium officinale.
A preparation method of a beautiful millettia root composition for regulating immunity comprises the following steps:
(1) taking beautiful millettia root, lucid ganoderma, szechuan lovage rhizome, dwarf lilyturf tuber, costus root, turmeric, lotus seed and dendrobium officinale according to the formula ratio, cleaning, drying at 65 ℃, and crushing to 25 meshes; adding 80% ethanol with a volume concentration of 8 times of the total mass of the medicinal materials, heating and reflux-extracting at 83 deg.C, and filtering to remove residue to obtain filtrate; extracting repeatedly for 3 times, and mixing the filtrates;
(2) and (2) drying the filtrate obtained in the step (1) at 45 ℃ under reduced pressure to obtain the composition for regulating the immunity.
Example 4
The bovine powerful composition for regulating immunity comprises the following components in parts by weight: 40 parts of beautiful millettia root, 25 parts of lucid ganoderma, 20 parts of szechuan lovage rhizome, 15 parts of dwarf lilyturf tuber, 15 parts of aquilaria sinensis, 10 parts of turmeric, 10 parts of lotus seed and 10 parts of dendrobium officinale.
A preparation method of a beautiful millettia root composition for regulating immunity comprises the following steps:
(1) taking beautiful millettia root, lucid ganoderma, szechuan lovage rhizome, dwarf lilyturf tuber, costus root, turmeric, lotus seed and dendrobium officinale according to the formula ratio, cleaning, drying at 60 ℃, and crushing to 30 meshes; adding 85% ethanol with a volume concentration of 6 times of the total mass of the medicinal materials, heating and reflux-extracting at 82 deg.C, and filtering to remove residue to obtain filtrate; extracting for 2 times, and mixing the filtrates;
(2) and (2) drying the filtrate obtained in the step (1) at 45 ℃ under reduced pressure to obtain the composition for regulating the immunity.
Example 5
The bovine powerful composition for regulating immunity comprises the following components in parts by weight: 50g of beautiful millettia root, 30g of lucid ganoderma, 30g of szechuan lovage rhizome, 30g of dwarf lilyturf tuber, 20g of costus root, 20g of turmeric, 15g of lotus seed and 15g of dendrobium officinale.
A preparation method of a beautiful millettia root composition for regulating immunity comprises the following steps:
(1) taking beautiful millettia root, lucid ganoderma, szechuan lovage rhizome, dwarf lilyturf tuber, costus root, turmeric, lotus seed and dendrobium officinale according to the formula ratio, cleaning, drying at 65 ℃, and crushing to 25 meshes; adding 70% ethanol with a volume concentration of 10 times of the total mass of the medicinal materials, heating and reflux-extracting at 80 deg.C, and filtering to remove residue to obtain filtrate; extracting repeatedly for 3 times, and mixing the filtrates;
(2) and (2) drying the filtrate obtained in the step (1) at 50 ℃ under reduced pressure to obtain the composition for regulating the immunity.
Influence of the composition for regulating immunity on immunity of mice
The experimental group respectively prepares extracts according to the following scheme, and the extracts are administrated by intragastric administration according to the administration amount of 400 mg/kg; the positive control group is administered with astragalus polysaccharide with the dosage of 400mg/kg and is administered by gastric lavage; the blank control group was given a gavage of the same volume of saline. Feeding for 15 days, and detecting each index.
(1) And (4) counting the weight gain and the feed consumption of each group, calculating the daily gain and the feed conversion ratio, and investigating the influence of different treatments on the growth performance of the mice.
(2) Each group was randomly selected 3 mice, blood was collected from the ocular veins, and blood cells were classified and counted using a blood cell analyzer.
(3) After the mice were sacrificed by removing their necks, the spleens and livers were collected, blotted with filter paper, weighed, and immune organ index was calculated.
Immune organ index ═ immune organ weight (g)/body weight x 100%
(4) Each group was prepared by tying 5 mice to the root of the tail with 1.50g of a weight, placing in deep water at 25 ℃ for forced swimming, and recording the exhaustion time.
The results are shown in tables 1 to 4.
The preparation scheme of the extract is as follows:
experimental group 1: a composition was prepared according to the method in example 1;
experimental group 2: a composition was prepared according to the method in example 2;
experimental group 3: a composition was prepared according to the method in example 3;
experimental group 4: a composition was prepared according to the method in example 4;
experimental group 5: a composition was prepared according to the method in example 5;
experimental group 6: the composition was prepared as in example 3, but with the formula removed from bovine stress and ganoderma lucidum;
experimental group 7: the composition was prepared as in example 3, but with the formula removed of chuanxiong rhizome and aquilaria sinensis;
experimental group 8: the composition was prepared as in example 3, but with the ophiopogon root and turmeric removed from the formulation;
experimental group 9: the composition was prepared according to the method in example 3, but lotus seed and dendrobium officinale were removed from the formulation.
Table 1 effect of the composition for regulating immunity according to the present invention on growth performance of mice
The growth performance is an important index which comprehensively reflects the health state and the digestive function of animals. As can be seen from Table 1, the composition for regulating immunity prepared in 5 embodiments of the invention can effectively improve the average daily gain of mice and reduce the feed conversion ratio of the mice. The daily gain is not only obviously higher than that of a blank control group and a positive control group, but also higher than that of other experimental groups, so that the composition for regulating the immunity effectively improves the daily gain of mice and reduces the feed conversion ratio. The invention has the advantages of promoting the digestive function of mice, improving the feed conversion rate and improving the growth performance of the mice. Moreover, the effect is remarkably improved by the combination proportion of the components, the composition of the components is changed, the effect is greatly reduced, although the effect is improved compared with that of a blank control group, the effect is still lower than that of a positive control group, and obvious difference exists.
TABLE 2 mouse immune cell count/1 x109Per L
As shown in Table 2, the immunity-regulating compositions prepared in experimental groups 1-5 can effectively increase the number of immune cells in a mouse. The action effect of the composition is not only obviously higher than that of a blank control group and a positive control group, but also higher than that of an experimental group 6-9, so that the composition for regulating the immunity effectively improves the number of immune cells of a mouse, and the action effect of the composition is better than that of other treatment groups.
TABLE 3 Effect of the Immunity-modulating compositions of the present invention on the immune organs of mice
As shown in Table 3, the immunity-regulating compositions prepared in experimental groups 1-5 and experimental groups 1-5 were effective in improving the immune organ index of mice. The action effect of the composition is not only obviously higher than that of a blank control group and a positive control group, but also higher than that of an experimental group 6-9, so that the composition for regulating the immunity effectively improves the immune organ index of the mouse, and the action effect of the composition is better than that of other treatment groups.
The development state of immune organs determines the state of immune functions of the body, and the quantity of immune cells can reflect the level of cellular immunity of the body, and reflects the immune state of the body today. Combining the data in table 2 and table 3, the composition for regulating immunity according to 5 embodiments of the present invention can significantly increase the number of immune cells and immune organ index in mice, and the effect is significantly higher than that of other treatment groups. The numbers of immune cells and immune organs in the experimental groups 6-9 are improved compared with those in the blank control group, but are still lower than those in the experimental groups 1-5, and the individual data are even lower than those in the positive control group. The composition for regulating the immunity has greatly reduced action effect by removing components in the formula.
TABLE 4 Effect of the Immunity-modulating compositions of the present invention on forced swim time in mice
The forced swimming time of the mouse can be used for inspecting the endurance capacity of the mouse, evaluating the anti-fatigue capability of the mouse and reflecting the immunity of the mouse from the side. As can be seen from Table 4, the immunity regulating composition prepared in experimental groups 1 to 5 can effectively improve the forced swimming time of mice, the action effect of the composition is not only obviously higher than that of a blank control group and a positive control group, but also higher than that of experimental groups 6 to 9, and the composition for regulating immunity of the invention effectively improves the number of immune cells of mice, and the action effect of the composition is better than that of other treatment groups. Although the forced swimming time of the experimental groups 6-9 is improved compared with that of the blank control group, the forced swimming time of the experimental groups 6-9 is still lower than that of the experimental groups 1-5, and the forced swimming time of the experimental groups 6, 7 and 9 is even lower than that of the positive control group. The components of the formula have synergistic effect, the composition of the formula is changed, the effect is greatly reduced, and the effect is remarkably different from that of the composition for regulating immunity.
The effect of the beautiful millettia root composition for regulating immunity on patients with low immunity
132 subjects with low immunity of 25-50 years old are randomly selected and divided into 11 groups, astragalus polysaccharide capsules are given to a positive control group, the immunity regulating compositions prepared in 5 embodiments are respectively given to an experimental group, the dose of the immunity regulating compositions is the same as that of the positive control group, and placebo with the same dose is given to a blank control group. The therapeutic effect was counted and the results are shown in Table 5.
TABLE 5 Effect of the Millettia speciosa champ composition for regulating immunity of the present invention on sleep
As can be seen from Table 5, the composition for regulating immunity prepared in 5 embodiments of the invention has significant treatment effect on patients with low immunity, and the total effective rate is not only obviously higher than that of a positive control group, but also higher than that of experimental groups 6-9, which shows that the composition for regulating immunity can regulate the immunity of a subject and effectively enhance the immunity of the organism. The composition of the formula is changed, the action effect is obviously reduced and is not only lower than that of 5 example groups, but also has a certain difference compared with a positive control group, which shows that the effects of the components of the composition for regulating immunity are mutually influenced, the composition has a certain synergistic effect, and the action effects are reduced to different degrees and are obvious in difference after the components are removed.
The present invention is not limited to the preferred embodiments, but rather, the present invention is intended to cover modifications, equivalents, improvements, and equivalents within the spirit and scope of the present invention.
Claims (9)
1. The millettia speciosa champ composition for regulating immunity is characterized by comprising the following components in parts by weight: 30-60 parts of beautiful millettia root, 20-40 parts of lucid ganoderma, 10-40 parts of szechuan lovage rhizome, 10-30 parts of dwarf lilyturf tuber, 10-30 parts of aquilaria sinensis, 5-20 parts of turmeric, 5-20 parts of lotus seed and 5-20 parts of dendrobium officinale.
2. The composition of claim 1, wherein the composition comprises: the beautiful millettia root composition for regulating immunity comprises the following components in parts by weight: 40-50 parts of beautiful millettia root, 25-30 parts of lucid ganoderma, 20-30 parts of szechuan lovage rhizome, 15-25 parts of dwarf lilyturf tuber, 15-25 parts of aquilaria sinensis, 10-15 parts of turmeric, 10-15 parts of lotus seed and 10-15 parts of dendrobium officinale.
3. A drug for regulating immunity, which is an ethanol extract of the beautiful millettia root composition according to claim 1 or 2.
4. The preparation method of the radix millettiae speciosae drug for regulating immunity as claimed in claim 3, which comprises the following steps:
taking radix millettiae speciosae, lucid ganoderma, ligusticum wallichii, radix ophiopogonis, radix aristolochiae, turmeric, lotus seeds and dendrobium officinale according to the formula amount, cleaning, drying, adding ethanol, heating, refluxing and extracting, and filtering to remove dregs to obtain filtrate; repeatedly extracting for 2-3 times, and mixing the filtrates; and drying the filtrate under reduced pressure to obtain the composition for regulating the immunity.
5. The preparation method of the radix millettiae speciosae drug for regulating immunity as claimed in claim 3, wherein the preparation method comprises the following steps: the temperature is controlled at 60-70 deg.C during the drying process, and the medicinal materials are pulverized to 20-30 mesh.
6. The preparation method of the radix millettiae speciosae drug for regulating immunity as claimed in claim 3, wherein the preparation method comprises the following steps: the volume concentration of the ethanol is 70-85%, and the mass of the ethanol added is 6-10 times of the total mass of the medicinal materials.
7. The preparation method of the radix millettiae speciosae drug for regulating immunity as claimed in claim 3, wherein the preparation method comprises the following steps: the temperature is controlled to be 80-85 ℃ in the reflux process, and the temperature is controlled to be 40-50 ℃ by decompression drying.
8. Use of the composition of beautiful millettia root for regulating immunity according to any one of claims 1 to 2, or the medicament for regulating immunity according to claim 3, or the medicament for regulating immunity prepared by the preparation method according to any one of claims 4 to 7 for preparing a preparation having the effect of regulating immunity.
9. A preparation for regulating immunity is characterized in that: the composition for regulating immunity of beautiful millettia root which comprises the composition for regulating immunity of any one of claims 1 to 2, or the medicament for regulating immunity of claim 3, or the medicament for regulating immunity which is prepared by the preparation method of any one of claims 4 to 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610309810.4A CN105920526B (en) | 2016-05-12 | 2016-05-12 | Millettia speciosa champ composition for regulating immunity and preparation method and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1198932A (en) * | 1997-05-08 | 1998-11-18 | 张志兴 | Medicated wine |
| CN103040924A (en) * | 2013-01-14 | 2013-04-17 | 海南师范大学 | Radix millettiae speciosae extract and application thereof in preparing drugs for treating osteoporosis |
| CN104055835A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Beautiful millettia root wall-broken preparation |
| CN105441280A (en) * | 2015-12-21 | 2016-03-30 | 肖开标 | Ganoderma lucidum medicinal wine, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103876143A (en) * | 2014-03-31 | 2014-06-25 | 苏志恒 | Sugar-free radix millettiae speciosae buccal tablet and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1198932A (en) * | 1997-05-08 | 1998-11-18 | 张志兴 | Medicated wine |
| CN103040924A (en) * | 2013-01-14 | 2013-04-17 | 海南师范大学 | Radix millettiae speciosae extract and application thereof in preparing drugs for treating osteoporosis |
| CN104055835A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Beautiful millettia root wall-broken preparation |
| CN105441280A (en) * | 2015-12-21 | 2016-03-30 | 肖开标 | Ganoderma lucidum medicinal wine, and preparation method thereof |
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