CN105920273A - Composition capable of improving and enhancing immunity of organism and preparation method - Google Patents
Composition capable of improving and enhancing immunity of organism and preparation method Download PDFInfo
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- CN105920273A CN105920273A CN201610500813.6A CN201610500813A CN105920273A CN 105920273 A CN105920273 A CN 105920273A CN 201610500813 A CN201610500813 A CN 201610500813A CN 105920273 A CN105920273 A CN 105920273A
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Abstract
The invention relates to a composition capable of improving and enhancing immunity of organism. The composition is prepared from the following raw materials in parts by weight: 200-300 parts of codonopsis pilosula, 200-300 parts of astragalus membranaceus, 100-200 parts of bighead atractylodes rhizome, 100-200 parts of glossy privet fruit, 100-150 parts of Chinese yam, 100-200 parts of rehmannia glutinosa, 100-200 parts of angelica sinensis, 100-200 parts of radix paeoniae alba, 50-100 parts of ligusticum wallichii, 50-100 parts of cortex acanthopanacis, 100-150 parts of the fruit of Chinese wolfberry and 50-100 parts of liquorice. A method comprises the following steps of: using 70-95% ethanol with the weight being 6-10 times of the weight of medicinal materials for extracting for 1-3 times, extracting for 1-1.5h at each time and filtering, thereby acquiring an extracting solution and a drug residue; combining the extracting solution, filtering, decompressing and recycling till no alcohol flavor exists, thereby acquiring alcohol extract; extracting the drug residue by adopting water with the weight being 6-10 times of the weight of the medicinal materials for 1-3 times, wherein the extracting at each time lasts for 1-1.5h; combining filtrate, concentrating the filtrate and acquiring the water extract; mixing the alcohol extract with the water extract, drying and acquiring the extract dry powder; mixing the dry powder with auxiliary materials; and preparing the corresponding preparation according to a conventional method. The research proves that the composition has the effect of enhancing immunity.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to, with Chinese herbal medicine for what raw material made, there is improvement and enhancing immunity
Compositions and preparation method.
Background technology
" immune " word, sees ming dynasty of china medical book " immunity class side " the earliest, refers to " release epidemic disease ", namely prevent and treat
The meaning of infectious disease." immune " word also has the ability meaning of body from viral, severe external environment, it is possible to refer to spiritual
Resistance.
Chinese medicine is thought, the key factor that human body is kept fit is health invigorating.Body constitution is congenital heredity and the day after tomorrow
Obtain intrinsic, the metastable personal characteristics in terms of morphosis, functional activity formed, and show as with psychological
The dependency of lattice.In general, the sturdy person of body constitution, negative and positive of qi and blood is sufficient, and function perfects, healthy energy virtual loss and health is thin and weak.
The generation of disease, is related to factor of both healthy energy and pathogen, be human body in the case of positive QI-insufficiency, pathogen
Take advantage of a weak point, destroy internal relative balance state and produce.Therefore the principle of prevention of diseae is also to set about in terms of two.
One is maintenance healthy energy, improves the resistance against diseases of body.Two is to avoid pathogen to attack machine table.
Healthy energy is with pathogen comparatively speaking.Healthy energy refers to the functive of the essence organizational structure such as qi-blood-body fluid and zang-fu differentiation
Existing.Whether normal the function of the histoorgans such as the power of healthy energy and essence qi-blood-body fluid etc. whether abundance, zang-fu differentiation is relevant.Essence,
Gas, blood, body fluid are the material bases producing healthy energy.Only the tissue organ function such as abundant, the zang-fu differentiation of energy and blood of human body body fluid is just
Often, in human body, healthy energy could be vigorous.
Along with the progress of society, that in many ways competes is day by day fierce, and the low crowd of immunity of organisms is the hugest, makes people
To improve immunity of organisms product demand grow with each passing day, the most more like the product of plant and Chinese medicine extract.
Summary of the invention
The technical problem to be solved in the present invention is to provide that a kind of prescription is simple, poor, the severe disease that is applicable to body immunity or
Having of postoperative the most patient improves and the compositions of enhancing immunity；The invention still further relates to have and improve and enhancing immunity
The preparation method of compositions.The present invention evaluates the function of this enhancing immunity compositions also by zoopery.
To this end, the present invention adopts the following technical scheme that a kind of compositions having and improving with enhancing human body immunity power, it is special
Levy and be to be made up of the crude drug of following weight proportioning: Radix Codonopsis 200 ~ 300 parts, the Radix Astragali 200 ~ 300 parts, the Rhizoma Atractylodis Macrocephalae 100 ~ 200 parts, female
Loyal son 100 ~ 200 parts, Rhizoma Dioscoreae 100 ~ 150 parts, 100 ~ 200 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 100 ~ 200 parts, the Radix Paeoniae Alba 100 ~ 200 parts, Rhizoma Chuanxiong 50 ~
100 parts, Cortex Acanthopancis 50 ~ 100 parts, Fructus Lycii 100 ~ 150 parts and 50 ~ 100 parts of Radix Glycyrrhizae.
Its preferred weight proportion is: Radix Codonopsis 250 parts, the Radix Astragali 200 parts, the Rhizoma Atractylodis Macrocephalae 120 parts, Fructus Ligustri Lucidi 150 parts, Rhizoma Dioscoreae 150
Part, 150 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 200 parts, the Radix Paeoniae Alba 120 parts, Rhizoma Chuanxiong 60 parts, Cortex Acanthopancis 60 parts, Fructus Lycii 120 parts, 60 parts of Radix Glycyrrhizae.
A kind of have the preparation method of composition improved with enhancing human body immunity power；Step is as described below:
(1) according to following weight parts proportioning weighting raw materials: Radix Codonopsis 200 ~ 300 parts, the Radix Astragali 200 ~ 300 parts, the Rhizoma Atractylodis Macrocephalae 100 ~ 200
Part, Fructus Ligustri Lucidi 100 ~ 200 parts, Rhizoma Dioscoreae 100 ~ 150 parts, 100 ~ 200 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 100 ~ 200 parts, the Radix Paeoniae Alba 100 ~ 200 parts, river
Rhizome of chuanxiong 50 ~ 100 parts, Cortex Acanthopancis 50 ~ 100 parts, Fructus Lycii 100 ~ 150 parts and 50 ~ 100 parts of Radix Glycyrrhizae；
(2) step (1) crude drug is entered container, the ethanol extraction 1 with the 70 ~ 95% of medical material weight 6～10 times～3 times, carry every time
Take 1 ~ 1.5h, filter to obtain extracting solution and medicinal residues；United extraction liquid, filters, and recovered under reduced pressure, to without alcohol taste, obtains alcohol-extracted extract；Medicinal residues
With the water extraction 1 of medical material weight 6 ~ 10 times～3 times, extracting 1 ~ 1.5h, merging filtrate, filtrate is concentrated to give the water extracted immersing paste every time；Close
And alcohol-extracted extract and the water extracted immersing paste, be dried and to obtain extract dry powder；
(3) above-mentioned extract dry powder is mixed with proper auxiliary materials, make corresponding preparation according to conventional formulation method.
Chinese herbal medicine ingredient is sufficiently complex, existing effective ingredient, has again invalid components and toxic component.In improving
The therapeutic effect of medical herbs, it is necessary to most effective component extracting the most to greatest extent, removes invalid components and toxic component.Owing to decocting method accords with
The custom of medical drugs in conjunction, thus for effective ingredient the most clearly Chinese crude drug or prescription, generally uses decocting method to extract, by
Lipophilic forms solvent system to hydrophilic or by low polarity to highly polar order.Extract various differences in spice component successively
Composition.In we, the multiple medical material such as Radix Codonopsis, the Radix Astragali has immunologic function facilitation, wherein ferulic acid, neutral oil total acid etc.
Effective ingredient, uses alcohol extracting method relatively water extraction extraction ratio high；In Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae etc., regulation immunity effective ingredient polysaccharide is easy
It is dissolved in water, can be selected for water extraction.Furthermore, have lipid to surround outside polysaccharide cell tissue more, first use alcohol extraction can destroy its cell week
The organizational structure enclosed, uses water to carry further and polysaccharide can be made to be easier to discharge, and beneficially effective ingredient carries to greatest extent
Take.
The present invention, based on Chinese medical theory, forms in conjunction with modern pharmacology prescription.Ingredient modern pharmacology shows
There is improvement or the effect of enhancing immunity more.Wherein, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae can spleen reinforcing, lung qi, the Radix Astragali and double benefit are defended solid
The effect of table；Radix Rehmanniae Preparata, Chinese angelica blood supplementing, it is possible to promote hemopoietic；The Radix Paeoniae Alba is nourished blood yin fluid astringing, had both nourished blood and has enriched blood, again can yin fluid astringing reasonable；Radix Codonopsis is mended
The merit of gas then enters sun with sun medicine and divides, and then enters cloudy point with cloudy medicine, can help the merit of Radix Paeoniae Alba yin fluid astringing, and in making body, negative and positive reach to coordinate to put down
Weighing apparatus；Slender acanthopanax leatherware invigorating the liver and kidney, effect of bone and muscle strengthening, and the merit of double tonification, rheumatism is won in skin, and the most non-its is taken charge of, and can work in coordination with increasing
Strong body resists the effect of extraneous six evils；The pungent scattered benefaction of Rhizoma Chuanxiong, i.e. enters blood system, and for example edema caused by disorder of QI, circulation of qi promoting of often holding concurrently of invigorating blood circulation.It is by Radix Codonopsis etc.
The effect of the hemopoietic of enriching blood of the medicines such as the property of the QI invigorating of medicine and Radix Rehmanniae Preparata combines, and is in harmonious proportion the two effect, reaches to mend and the most stagnant, gas and blood
Being in harmonious proportion, in order, the effect on the whole body is moistened in nutrition in operation；QI invigorating is double enriches blood, gas promoting the circulation of blood then blood, and blood spreading nourishes whole body, makes
Negative and positive of qi and blood is abundant, then human righteousness is vigorous.The vigorous one side of healthy energy can resist exopathogen, prevents pathogenic factor from invading, or morbidity rear-guard
Heresy is gone out；On the other hand can carry out self regulation, adapt to external environment condition change, maintain internal balance, or to damaging after being ill
The reparation of tissue, makes human body get well.Side uses enriching spleen-QI, the medicine of lung qi so that lung can normally include the gas of nature in,
Combine generation pectoral qi with the essence-QI from water and grain of spleen transporting.Pectoral qi spreading whole body, is divided into two, and ying-qi row, in arteries and veins, defends gas row
Outside arteries and veins, being dispersed throughout body surface, one of its function is exactly defence pathogen ab extra, escorts body surface, and protection body is not by diseases caused by exogenous pathogenic factor
Heresy invasion and attack.I.e. Gu Wei body itself, can defend again external pathogen, enhancing body resistance against diseases.
The pharmacological function of crude drug of the present invention is as follows:
(1) Radix Codonopsis: for Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or the root of radix codonpsis tangshen, there is spleen reinforcing lung qi, the merit enriched blood, promote the production of body fluid
Effect, is mainly used in treating the diseases such as deficiency of both the splenic and pulmonary QI, QI and blood deficiency, gas Tianjin two wound.Pharmaceutical research shows that it has enhancing immunity
Function.
(2) Radix Astragali: for leguminous plant Radix Astagali or the root of Radix Astragali, has an invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus,
Effect of expelling pus and promoting granulation.The pharmacological action relevant to Radix Astragali effect is enhancing human body immunity function, strengthens hemopoietic function, improves thing
Matter metabolism, anti-stress, slow down aging etc. act on；Also have heart tonifying, regulation blood pressure, antiviral property myocarditis, protect the liver, antiulcer etc.
Effect.
(3) Rhizoma Atractylodis Macrocephalae: for the rhizome of the feverfew Rhizoma Atractylodis Macrocephalae, can invigorating the spleen and benefiting QI, dampness diuresis, hidroschesis is antiabortive.Based on spleen invigorating,
It is described as " spleen air making-up and spleen enlivening the first key medicine ".Modern pharmacological research shows, it can be obviously promoted the synthesis of Protein in small intestine；
Can promote cellular immune function, have a certain upgrade leukocyte effect.
(4) Fructus Ligustri Lucidi: for the mature fruit of Oleaceae plants Fructus Ligustri Lucidi.Can enhancing non-specific immunity function, to abnormal
Immunologic function has dual regulation, and the leukopenia caused by chemotherapy and radiation is had rising effect；Super oxygen can be improved
Compound dismutase (SOD) activity, has certain anti-aging effects.
(5) Rhizoma Dioscoreae: the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae, has spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the effect in foster puckery Tianjin of kidney.Face
Can be used for treating insufficiency of the spleen, the deficiency of the lung, the disease such as suffer from a deficiency of the kidney on Chuan.Chinese yam polysaccharide can promote that the hypertrophy of T cell in spleen and NKT are thin
Born of the same parents' toxic action to lymphocytic cancer cell.Chinese yam polysaccharide can be obviously promoted normal mouse Peritoneal Macrophage Phagocytosis and just
Often mouse lymphocyte converts, and also significantly improves normal mouse periphery blood T cell percentage ratio simultaneously.
(6) Radix Rehmanniae Preparata: the processed process of preparing Chinese medicine of tuber for scrophulariaceae rehmannia glutinosa plant forms.For the qi-restoratives key medicine that nourishes blood.It effectively becomes
Divide polysaccharide can be remarkably reinforced and improve the immunocompetence of rat.
(7) Radix Angelicae Sinensis: be used as medicine with the root of umbelliferae angelica, sweet in the mouth, pungent, bitter, warm in nature, can replenishing and activating blood, loosening bowel to relieve constipation.
Essentials of Matea Medica calls it: " blood deficiency can be mended, and blood depletion can be moistened ", to insufficiency of generating and transforming QI and blood, or QI-blood circulation is slow and blood deficiency dryness of the intestine
Constipation person, informal dress effect is good.Clinical and it is demonstrated experimentally that this product has anti-anemia action, vitamin antagonist E to lack and calm, analgesia, blood fat reducing etc.
Effect, also can increase coronary artery blood flow.Radix Angelicae Sinensis and various active composition thereof have facilitation to body's immunity.Radix Angelicae Sinensis
Injection can significantly improve macrophage phagocytosis of mice, activates lymph and produces antibody and promote the generation of lysozyme；It becomes
Point ferulic acid can mild activation mouse spleen lymphocyte, promote the propagation of splenocyte, the little of ConA induction can be obviously promoted
Mus splenocyte DNA and the synthesis of protein；Radix Angelicae Sinensis neutral oil total acid can strengthen the phagocytic function of macrophage and promote to drench
Bar cell transformation.
(8) Radix Paeoniae Alba: for the root of ranunculaceae plant Radix Paeoniae.Radix Paeoniae Alba water decoction can antagonism cyclophosphamide to mice peripheral t lymph
The inhibitory action of cell, is allowed to recover normal level, shows that the Radix Paeoniae Alba just can make to be in the cellular immune function recovery of low state
Often.
(9) Rhizoma Chuanxiong: for the rhizome of samphire Rhizoma Chuanxiong, there is effect of blood-activating and qi-promoting, wind-expelling pain-stopping.
(10) Cortex Acanthopancis: derive from the dry root bark of Araliaceae acanthopanax gracilistylus.Tool invigorating the liver and kidney, effect of bone and muscle strengthening,
And the merit of double tonification." book on Chinese herbal medicine want to change record ": " if rheumatism is won in skin, the most non-its is thought.”
(11) Fructus Lycii: for the dry mature fruit of matrimony vine of solanaceae plant.Sweet in the mouth is put down, and returns liver, kidney channel.It has nourishing liver
Kidney, benefit intensive culture blood, improving eyesight removing nebula, effect of nourishing the lung to arrest cough.For the atrophic debility of bones of suffering from a deficiency of the kidney, soreness of waist and knee joint, vertigo and tinnitus, blurred vision is not clear,
The diseases such as blood deficiency and yellow complexion.Immunity there is is facilitation, has immunoregulation effect simultaneously, have normal healthy people notable leukocyte increasing to make
With；The antibody tormation of normal body is obviously promoted effect.It also has defying age, mutation, antitumor, blood fat reducing, guarantor
Liver and the effect such as anti-fatty liver, blood pressure lowering.
(12) Radix Glycyrrhizae: for the root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., " book on Chinese herbal medicine is just ": " taste is extremely
Sweet, obtain the property of neutralization, have a merit adjusting benefits, therefore solutions that obtain of poison it is malicious, firm medicine obtains its property of sum ... help join stilbene become the deficiency of vital energy it
Merit.”
Tool nonspecific immunity regulation effect, mainly strengthens immunization of cell, strengthens phagocytic function, the most optionally increases
The multiplication capacity of strong helper T cell and activity.
The present invention is by traditional Chinese medical science compatibility theory, with reference to modern medicines achievement in research, draws through long felt screening.Its
It is that prescription is simple, a kind of improvement of instant effect and the compositions of enhancing human body immunity power, prove through modern medicine and pharmacological research
All there is definite enhancing immunity effect.Each amounts of components has good curative effect in the range of described and has no side effect.
The all medicines of the present invention act on jointly, have root active, and long-term low dose is taken, and can improve and eliminate the state that immunity of organisms is low.
Efficacy test content and toxicological experiment content that of the present invention animal experiment carried out are presented herein below.
First, efficiency index evaluation
(1) experiment material and method:
1, material and experimental situation: capsule of the present invention (is prepared according to the method for the embodiment of the present invention 1).Laboratory animal is ground by animal
Studying carefully the cleaning grade healthy adult Kunming kind female mice that center provides, body weight is 20 ± 2 grams.Laboratory animal room temperature 22 ~ 25
DEG C, relative humidity: 45% ~ 60%.
2, experimental technique: laboratory animal 240, body weight is 20 ± 2 grams, and every 48 mices are 1 group, totally 5 groups.Immunity I group,
Carry out dirty/weight ratio pH-value determination pH；Immunity II group, carries out the mouse spleen lymphocyte transformation experiment of ConA induction；Immunity III group,
Carry out delayed allergy experiment；Immunity IV ~ V group, carry out respectively carbonic clearance experiment, peritoneal macrophage phagocytosis chicken red carefully
Born of the same parents' measuring.
3, dosage and the mode that gives are tested and are set 0.24,0.48,3 dosage groups of 0.96g/kg/d and 1 solution control group,
Often 12 animals of group.Before experiment, capsule distilled water of the present invention is made into the suspension of desired concn, by the body of 0.2mL/10g/d
Long-pending giving corresponding dosage treated animal gavage, solvent control group gives isopyknic distilled water, every day gavage 1 time, continuous gavage 30
My god, carry out the mensuration of every immune indexes.
4, detection method
4.1 internal organs/weight ratio pH-value determination pH: mice is put to death in test, weighs, takes out thymus and spleen, calculates internal organs/body after weighing
Anharmonic ratio value (organ weight ratio value (%)=internal organs weight (g)/whole body weight (g) × 100).
4.2 ConA inducing mouse Splenic vein hemodynamics experiment (mtt assay): take the spleen of mice under aseptic condition, point
From single splenocyte, adjusting cell concentration with RPMI RPMI-1640 is 3 × 106/mL.By mtt assay microplate reader, with
570nm wavelength measures optical density (OD value).Deduct by the OD value adding ConA hole and be not added with the OD value in ConA hole and represent lymphocyte
Multiplication capacity.
4.3 delayed allergies: the sheep red blood cell (SRBC) inducing mouse DTH(foot sole of the foot thickens method): take Sanguis caprae seu ovis, use physiology salt
Water 3 times (2000rpm, 10min) of washing, every mice is through lumbar injection 2%(V/V, with normal saline) sheep red blood cell (SRBC)
0.2ml, after sensitization 4 days, measures left back sufficient sole of the foot portion thickness, and same position is measured three times, averages；Then at measuring point skin
Hemostasis 20(V/V, with normal saline) ovine cells 20 μ l, within latter 24 hours, measure left back sufficient sole of the foot portion thickness in injection, with
Before and after attack, the difference of foot sole of the foot thickness represents the degree of DTH.
4.4 mice carbonic clearance experiments: last is to 1h after the present invention, through mouse tail vein india ink 0.2ml/10g, in
After injection prepared Chinese ink, 5min, 10min, 15min, 20min take blood 20 μ l with quantitative blood taking tube from mouse orbit posterior vein respectively, and
It is blown into 2mL0.1%Na at once2CO3In solution, shake up.With Na2CO3Solution makees blank, exists with spectrophotometer
675nm wavelength light-metering absorbance, and obtain by formula and clean up index (k), phagocytic index (α).
4.5 Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment (in vitro method): test first 5 days to every mouse peritoneal
Inject 2% hematocrit sheep red blood cell (SRBC) 0.2ml, put to death mice with cervical dislocation, be administered to give mice through abdominal cavity and contain 5% Ox blood serum
Hank, s liquid 5ml/ only, extract ascites 1 ~ 2ml after about 2 minutes, Hank, s liquid be configured to 1% chicken erythrocyte suspension 0.5ml
Add in test tube with the ascites of 0.5ml, mixing, take suspension 0.5ml smear, put into the porcelain dish being lined with wet gauze, be placed in 37
30min in DEG C constant temperature oven, takes out after slide rinses in normal saline and dries, with methanol: acetone (1:1) solution is fixed, and 4%
(V/V) Giemsa-phosphate buffer dyeing, then with distilled water rinse, observed and recorded phagocytosis chicken red blood cell macrophage number and
The chicken red blood cell number swallowed, calculates phagocytic rate and phagocytic index.
5, data process and judge with result: experimental data statistics application SPSS statistical software carries out variance analysis Statistics Division
Reason.In all aobvious positive of cellular immune function, monocytes/macrophages function 2 aspect result, can determine that the present invention has enhancing immunity
The effect of power.Result judges as described below:
The impact on Mouse Weight of 5.1 capsules of the present invention: the immunity mice original body mass mean of I ~ V group be 19.7 ± 0.6g ~
Between 20.9 ± 1.0g, and compare between the 19.9 ± 0.8g ~ 20.7 ± 1.1g of solution control group, without significant (P >
0.05), i.e. the original body mass of mice more equalizes between each group.After experiment terminates, the Mouse Weight of immunity I ~ V group increases all
Number is between 33.9 ± 1.5g ~ 35.4 ± 1.2g, and compares between the 34.2 ± 1.6g ~ 35.5 ± 1.9g of solution control group, nothing
Significant (P > 0.05), shows that the body weight of mice is increased by capsule of the present invention and has no significant effect.
Capsule of the present invention is as shown in table 1 on the impact of mouse immune organ/body weight ratio.As known from Table 1: per os gavage is little
The capsule of the present invention of the uncomfortable dosage of Mus is after 30 days, the thymus/body weight of mice and the ratio of spleen/body weight and solution control group ratio
Relatively, difference that there are no significant (P > 0.05), show that the immune organ of mice is had no significant effect by capsule of the present invention.
The impact on mouse cell immunity of 5.2 capsules of the present invention
5. 2.1 capsules of the present invention are as shown in table 2 on the impact of ConA inducing mouse Splenic vein hemodynamics ability.Can from table 2
Know: the lymphocyte transformation ability of capsule of the present invention each dosage group mice is above solution control group, and middle and high dosage group with
Solution control group compares, and has significant difference (high dose group P of the present invention < 0.01), points out under this experimental condition, show this
' Yanming ' capsules for clearing has promotion mouse lymphocyte propagation, the effect of conversion capability.
Capsule the most of the present invention is as shown in table 3 on the impact of mice delayed allergy (DTH).As known from Table 3: this
The swelling degree of the paw of invention capsule each dosage group is above solution control group, and the sufficient sole of the foot of capsule of the present invention middle and high dosage group
Swelling compares with solvent control group, have significant difference (dosage group P in the present invention < and 0.05, high dose group P of the present invention <
0.01), pointing out under this experimental condition, capsule of the present invention can strengthen the delayed allergy of mice.
The impact on macrophage phagocytosis of mice of 5.3 capsules of the present invention
Capsule the most of the present invention is as shown in table 4 on the impact of mouse macrophage carbonic clearance.As known from Table 4: capsule of the present invention
The phagocytic index of each dosage group mice is above solution control group, and middle and high dosage group compares with solution control group, has aobvious
Writing sex differernce (P < 0.05), point out under this experimental condition, capsule of the present invention has promotion mouse macrophage carbonic clearance function
Effect.
The impact that capsule the most of the present invention swallows chicken red blood cell ability to the peritoneal macrophage of mice is as shown in table 5.
As known from Table 5: the peritoneal macrophage of the present invention each dosage group mice is to the phagocytic rate of chicken red blood cell and phagocytic index and solution
Matched group compares, and has significant difference (phagocytic rate P < 0.05, phagocytic index P < 0.01), points out under this experimental condition, this
' Yanming ' capsules for clearing has obvious facilitation to the phagocytic function of Turnover of Mouse Peritoneal Macrophages.
(2) conclusion
Originally test result indicate that, capsule of the present invention all has stronger facilitation to cellular immunization, macrophage phagocytic function.
The prompting present invention has the function of enhancing immunity.
Second, acute toxicity test
(1) experiment material and condition
1, animal: Kunming mouse, body weight 20 ± 2g, male and female half and half.
2, health product: making capsule according to method described in the embodiment of the present invention 1, the used time pours out content, uses distilled water
It is made into required confession reagent liquid.
3, solvent: distilled water.
Condition: temperature 22-25 DEG C, humidity is 50%-60%.
(2) experimental technique
1, animal packet: set four dosage groups, often 10 mices of group, male and female half and half.
2, dosage and give mode: experiment sets 1000,2150,4640,4 dosage groups of 10000mg/kg/d.Use gavage
Mode be administered, every day gavage 1 time, Continuous Observation 7 days.
(3) experimental result: experimental result is shown in Table 6.
As shown in Table 6: having no in the observation period that poisoning symptom and death condition occurs in experiment mice, capsule of the present invention is to mice
LD50 value more than 10000mg/kg, according to acute toxicity grading criteria, its acute toxicity belongs to actual non-toxic type.
Detailed description of the invention
Embodiment 1；(1) Radix Codonopsis 250g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 120g, Fructus Ligustri Lucidi 150g, Rhizoma Dioscoreae 150g, Radix Rehmanniae Preparata are weighed
150g, Radix Angelicae Sinensis 200g, Radix Paeoniae Alba 120g, Rhizoma Chuanxiong 60g, Cortex Acanthopancis 60g, Fructus Lycii 120g, Radix Glycyrrhizae 60g；
(2) step (1) crude drug is entered container, the ethanol extraction with 80% 2 times, for the first time with 13kg ethanol extraction 1.5h, second
Secondary 10kg ethanol extraction 70min；Filter to obtain extracting solution and medicinal residues；United extraction liquid, filters, and recovered under reduced pressure, to without alcohol taste, obtains
Alcohol-extracted extract；Medicinal residues water extraction 2 times, the water of first time 15kg, extracts 1h, the water of second time 13kg, extracts 1h, merge 2
Secondary filtrate, filtrate be concentrated into relative density be 1.32(measure temperature 55 DEG C) the water extracted immersing paste；Merge alcohol-extracted extract and propose leaching with water
Cream, be dried to obtain extract dry powder 280g；
(3) by extract dry powder and starch 135g mixing granulation, it is dried, adds magnesium stearate 2.5g, mixing, load capsule, to obtain final product.
Specification: 0.4g/ grain.Usage and dosage: 3 times on the one, one time 5.
Embodiment 2；(1) Radix Codonopsis 200g, Radix Astragali 250g, Rhizoma Atractylodis Macrocephalae 150g, Fructus Ligustri Lucidi 120g, Rhizoma Dioscoreae 130g, Radix Rehmanniae Preparata 190g, when
Return 170g, Radix Paeoniae Alba 150g, Rhizoma Chuanxiong 80g, Cortex Acanthopancis 50g, Fructus Lycii 100g, Radix Glycyrrhizae 70g；
(2) step (1) crude drug is entered container, the ethanol extraction with 85% 2 times, for the first time with 16kg ethanol extraction 1 h, second
Secondary 11kg ethanol extraction 1h；Filter to obtain extracting solution and medicinal residues；United extraction liquid, filters, and recovered under reduced pressure, to without alcohol taste, obtains alcohol extraction
Extractum；Medicinal residues extracting in water 3 times, the water of first time 13kg, extracts 1.2h, for the second time, the water of third time 10kg, extraction
1h, merges 3 filtrates, filtrate be concentrated into relative density be 1.30(measure temperature 60 C) the water extracted immersing paste；Merge alcohol-extracted extract
With the water extracted immersing paste, be dried to obtain extract dry powder 286g；
(3) by extract dry powder and starch 110g, carboxymethyl starch sodium 20g mixing granulation, 65 DEG C dried, adds magnesium stearate
2g, with 14 mesh sieve granulate tablettings.Specification: tablet weight: 0 .4g/ sheet.Usage and dosage: 3 times on the one, one time 5.
Embodiment 3；(1) Radix Codonopsis 300g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 120g, Fructus Ligustri Lucidi 150g, Rhizoma Dioscoreae 150g, Radix Rehmanniae Preparata are weighed
150g, Radix Angelicae Sinensis 150g, Radix Paeoniae Alba 120g, Rhizoma Chuanxiong 60g, Cortex Acanthopancis 80g, Fructus Lycii 120g, Radix Glycyrrhizae 80g；
(2) by the crude drug of step (1) with 75% ethanol extraction 2 times, the ethanol extraction 1.5h of first time 16.5kg, first
The ethanol extraction 1.5h of secondary 13.5kg, filters to obtain extracting solution and medicinal residues；United extraction liquid, filters, recovered under reduced pressure to without alcohol taste,
Obtain alcohol-extracted extract；Medicinal residues add 14kg water extraction 1 time, filter, be concentrated into relative density be 1.35(measure temperature 50 C) leaching
Cream, merges alcohol-extracted extract and the water extracted immersing paste, is dried and to obtain extract dry powder 295g；
(3) said extracted thing is stirred mixing with sucrose 490g, dextrin 130g, adjusts humidity soft material with 60% ethanol, pelletize,
65 DEG C of dried granulate, subpackage.Specification: 5g/ bag.Usage and dosage: 3 times on the one, one time 1 bag.
Embodiment 4；(1) Radix Codonopsis 250g, Radix Astragali 300g, Rhizoma Atractylodis Macrocephalae 100g, Fructus Ligustri Lucidi 180g, Rhizoma Dioscoreae 120g, Radix Rehmanniae Preparata are weighed
170g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 100g, Rhizoma Chuanxiong 100g, Cortex Acanthopancis 90g, Fructus Lycii 140g, Radix Glycyrrhizae 50g；
(2) by the crude drug of step (1) ethanol extraction 3 times, for the first time with 90% ethanol 14.3kg, extract 1.2 h, second
Secondary, third time extracts 1 .5h, 1.2h with the ethanol 13.5kg of 80%, filters to obtain extracting solution and medicinal residues；United extraction liquid, filters,
Recovered under reduced pressure, to without alcohol taste, obtains alcohol-extracted extract；Medicinal residues extracting in water 3 times, adds 15kg water extraction 80min for the first time, and second time adds
12.5kg water extraction 1.2h, third time adds 10kg water extraction 1h, merges 3 filtrates, and it is that 1.30(surveys that filtrate is concentrated into relative density
Fixed temperature 58 DEG C) the water extracted immersing paste；Merge alcohol-extracted extract and the water extracted immersing paste, be dried and to obtain extract dry powder 312g；
(3) above-mentioned extract dry powder is stirred mixing with sucrose 500g, dextrin 120g, adjust humidity soft material, system with 60% ethanol
Grain, 65 DEG C of dried granulate, subpackage.Specification: 5g/ bag.Usage and dosage: 1 time on the one, one time 3 bags.
Embodiment 5；(1) Radix Codonopsis 230g, Radix Astragali 250g, Rhizoma Atractylodis Macrocephalae 200g, Fructus Ligustri Lucidi 100g, Rhizoma Dioscoreae 100g, Radix Rehmanniae Preparata are weighed
200g, Radix Angelicae Sinensis 130g, Radix Paeoniae Alba 200g, Rhizoma Chuanxiong 90g, Cortex Acanthopancis 60g, Fructus Lycii 130g, Radix Glycyrrhizae 100g；
(2) by the crude drug of step (1) ethanol extraction 3 times, for the first time with 80% ethanol 15kg, extract 1 h, for the second time 75%
Ethanol 13.5kg extract 75min, third time with 75% ethanol 16kg extraction 1.2h, filter to obtain extracting solution and medicinal residues；Merging carries
Taking liquid, filter, recovered under reduced pressure, to without alcohol taste, obtains alcohol-extracted extract；Medicinal residues extracting in water 2 times, adds 18kg water extraction 1.5h for the first time,
Second time add 14kg water extraction 1.2h, merges 2 filtrates, filtrate be concentrated into relative density be 1.33(mensuration temperature 55 DEG C) water
Extracted extract；Merge alcohol-extracted extract and the water extracted immersing paste, be dried and to obtain extract dry powder 315g；
(3) by extract dry powder and starch 90g mixing granulation, it is dried, adds magnesium stearate 2.1g, mixing, load capsule, to obtain final product.
Specification: 0.4g/ grain.Usage and dosage: 3 times on the one, one time 5.
Embodiment 6；(1) Radix Codonopsis 260g, Radix Astragali 220g, Rhizoma Atractylodis Macrocephalae 160g, Fructus Ligustri Lucidi 200g, Rhizoma Dioscoreae 120g, Radix Rehmanniae Preparata 100g, when
Return 180g, Radix Paeoniae Alba 160g, Rhizoma Chuanxiong 50g, Cortex Acanthopancis 100g, Fructus Lycii 150g, Radix Glycyrrhizae 100g；
(2) step (1) crude drug is entered container, the ethanol extraction with 80% 2 times, for the first time with 16kg ethanol extraction 1.3h, second
Secondary 14kg ethanol extraction 1.5h；Filter to obtain extracting solution and medicinal residues；United extraction liquid, filters, and recovered under reduced pressure, to without alcohol taste, obtains alcohol
Extracted extract；Medicinal residues extracting in water 2 times, the water of first time 16kg, extracts 1.2h, the water of second time 13kg, extracts 1h, merge
2 filtrates, filtrate be concentrated into relative density be 1.32(measure temperature 50 C) the water extracted immersing paste；Merge alcohol-extracted extract and propose leaching with water
Cream, be dried to obtain extract dry powder 306g；
(3) by extract dry powder and starch 80g, carboxymethyl starch sodium 10g mixing granulation, 65 DEG C dried, adds magnesium stearate
2.2g, with 14 mesh sieve granulate tablettings.Specification: tablet weight: 0 .4g/ sheet.Usage and dosage: 3 times on the one, one time 5.
Claims (3)
1. one kind has the compositions improved with enhancing human body immunity power, it is characterised in that by the crude drug system of following weight proportioning
Become: Radix Codonopsis 200 ~ 300 parts, the Radix Astragali 200 ~ 300 parts, the Rhizoma Atractylodis Macrocephalae 100 ~ 200 parts, Fructus Ligustri Lucidi 100 ~ 200 parts, Rhizoma Dioscoreae 100 ~ 150 parts, ripe
100 ~ 200 parts of ground, Radix Angelicae Sinensis 100 ~ 200 parts, the Radix Paeoniae Alba 100 ~ 200 parts, Rhizoma Chuanxiong 50 ~ 100 parts, Cortex Acanthopancis 50 ~ 100 parts, Fructus Lycii 100
~ 150 parts, 50 ~ 100 parts of Radix Glycyrrhizae.
A kind of compositions with improvement and enhancing human body immunity power the most according to claim 1, it is characterised in that preferably
Crude drug weight proportion be: Radix Codonopsis 250 parts, the Radix Astragali 200 parts, the Rhizoma Atractylodis Macrocephalae 120 parts, Fructus Ligustri Lucidi 150 parts, Rhizoma Dioscoreae 150 parts, Radix Rehmanniae Preparata
150 parts, Radix Angelicae Sinensis 200 parts, the Radix Paeoniae Alba 120 parts, Rhizoma Chuanxiong 60 parts, Cortex Acanthopancis 60 parts, Fructus Lycii 120 parts, 60 parts of Radix Glycyrrhizae.
3. one kind has the preparation method of composition improved with enhancing human body immunity power；It is characterized in that the following institute of preparation process
State:
(1) according to following weight parts proportioning weighting raw materials: Radix Codonopsis 200 ~ 300 parts, the Radix Astragali 200 ~ 300 parts, the Rhizoma Atractylodis Macrocephalae 100 ~ 200
Part, Fructus Ligustri Lucidi 100 ~ 200 parts, Rhizoma Dioscoreae 100 ~ 150 parts, 100 ~ 200 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 100 ~ 200 parts, the Radix Paeoniae Alba 100 ~ 200 parts, river
Rhizome of chuanxiong 50 ~ 100 parts, Cortex Acanthopancis 50 ~ 100 parts, Fructus Lycii 100 ~ 150 parts and 50 ~ 100 parts of Radix Glycyrrhizae；
(2) step (1) crude drug is entered container, the ethanol extraction 1 with the 70 ~ 95% of medical material weight 6～10 times～3 times, carry every time
Take 1 ~ 1.5h, filter to obtain extracting solution and medicinal residues；United extraction liquid, filters, and recovered under reduced pressure, to without alcohol taste, obtains alcohol-extracted extract；Medicinal residues
With the water extraction 1 of medical material weight 6 ~ 10 times～3 times, extracting 1 ~ 1.5h, merging filtrate, filtrate is concentrated to give the water extracted immersing paste every time；Close
And alcohol-extracted extract and the water extracted immersing paste, be dried and to obtain extract dry powder；
(3) above-mentioned extract dry powder is mixed with proper auxiliary materials, make corresponding preparation according to conventional formulation method.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106138977A (en) * | 2016-09-16 | 2016-11-23 | 成都市飞龙水处理技术研究所 | A kind for the treatment of has a delicate constitution and the Chinese medicine composition of enhancing immunity and preparation method |
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|---|---|---|---|---|
| CN1217940A (en) * | 1997-11-25 | 1999-06-02 | 史天阳 | Medicinal health-care spirit and preparing method therefor |
| CN102319351A (en) * | 2011-09-22 | 2012-01-18 | 王璐 | Blood enriching and qi replenishing health-care product |
| CN103405569A (en) * | 2013-08-30 | 2013-11-27 | 刘丽华 | Traditional Chinese medicine preparation for replenishing Qi and blood |
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2016
- 2016-06-30 CN CN201610500813.6A patent/CN105920273A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217940A (en) * | 1997-11-25 | 1999-06-02 | 史天阳 | Medicinal health-care spirit and preparing method therefor |
| CN102319351A (en) * | 2011-09-22 | 2012-01-18 | 王璐 | Blood enriching and qi replenishing health-care product |
| CN103405569A (en) * | 2013-08-30 | 2013-11-27 | 刘丽华 | Traditional Chinese medicine preparation for replenishing Qi and blood |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138977A (en) * | 2016-09-16 | 2016-11-23 | 成都市飞龙水处理技术研究所 | A kind for the treatment of has a delicate constitution and the Chinese medicine composition of enhancing immunity and preparation method |
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Application publication date: 20160907 |