CN105910847B - A kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount and method - Google Patents
A kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount and method Download PDFInfo
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- CN105910847B CN105910847B CN201610203354.5A CN201610203354A CN105910847B CN 105910847 B CN105910847 B CN 105910847B CN 201610203354 A CN201610203354 A CN 201610203354A CN 105910847 B CN105910847 B CN 105910847B
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- 239000011159 matrix material Substances 0.000 claims abstract description 10
- 238000001259 photo etching Methods 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000001338 self-assembly Methods 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
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- 239000010409 thin film Substances 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
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- 238000011068 loading method Methods 0.000 description 2
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- VIFIHLXNOOCGLJ-UHFFFAOYSA-N trichloro(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)silane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CC[Si](Cl)(Cl)Cl VIFIHLXNOOCGLJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
Abstract
The invention discloses a kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount and methods, described device includes fluid inlet, air pressure inlet, lyophoby micro-valve, capillary channel and the nozzle of matrix and formation on the matrix, the capillary channel includes the multiple branches for being formed as the main line of loop and being connected in parallel between the main line and the nozzle, the fluid inlet connects the main line with the air pressure inlet, each branch road is equipped with the lyophoby micro-valve with setting pressure voltage based on lyophoby principle, and the outlet of each branch connects the nozzle.The present invention can facilitate, is flexible, accurately handling liquid extraction of tens picoliters to tens nanoliter volumes.
Description
Technical field
The present invention relates to microfluidic control fields, more specifically to a kind of adjustable lyophoby micro-valve type micro of liquid-taken amount
Liquid extraction apparatus and method.
Background technology
Micro-fluidic technologies refer to the technology for being controlled fluid, being operated and being detected under micro-scale.As biology is examined
The development in the fields such as survey, pharmaceutics, environmental science needs the amount of liquid extracted constantly to reduce, in protein crystallization experiments, only
The liquid for needing tens nanoliters, in DNA, gene studies, amount of liquid is even more as low as hundreds of picoliters.It is contemplated that being ground in following
In studying carefully, the amount of liquid will be further reduced, and more stringent requirements are proposed for this performance accuracy to microfluid control device.
Microfluid control device includes Micropump, micro-valve, micro-mixer, mini sprinkler etc., for being driven to micro fluid,
The operations such as drainage, mixing, extraction, distribution, blocking.Wherein micro-valve is to play the important devices of the restriction effect of liquid in runner,
Micro-valve can be divided into two class of active micro valve and Passive microvalve, and the main distinction is whether valve arrangement itself has actuator, aggressive valve
It is the opening and closing that micro-valve is realized by the movement of actuator, passive valve does not have actuator, and opening and closing is realized in the change by fluid parameter itself.
The advantages of passive valve, is embodied in simple in structure, easy processing, occupies little space, good compatibility, is suitable for the microfluid of simple occasion
Valve control.Using micro-valve to the restriction effect of liquid stream, it can be achieved that the isolation and extraction of micro liquid, by the structure design of micro-valve,
Accurately control the volume of extracting liq.Liquid releasing valve is one kind of Passive microvalve, by reducing the surface energy in valve area, utilizes liquid
Surface tension block liquid flowing, increase fluid pressure valve can be made to open.
Invention content
It is a primary object of the present invention to overcome the deficiencies in the prior art, solve existing liquid extraction apparatus and lack picoliters grade
The problem of liquid handling capacity, provides a kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount and method, can be square
Just liquid extraction of tens picoliters to tens nanoliter volumes, flexibly, is accurately handled.
To achieve the above object, the present invention uses following technical scheme：
A kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount, including matrix and formation are on the matrix
Fluid inlet, air pressure inlet, lyophoby micro-valve, capillary channel and nozzle, the capillary channel includes being formed as a loop
Main line and the multiple branches being connected in parallel between the main line and the nozzle, the fluid inlet and the air pressure inlet connect
The main line is connect, each branch road is equipped with the lyophoby micro-valve with setting pressure voltage based on lyophoby principle, and each branch goes out
Mouth connects the nozzle.
Further：
The pressure voltage of at least partly lyophoby micro-valve of branch road is different.
The multiple branch abreast intersects vertically with the main line.
Preferably, the main line be arranged to tool there are two half round runner as opposed end, pass through two line flowing channels
It is connected and constitutes loop, the multiple branch connection is wherein on straight line runner.
The liquid inlet, air pressure inlet, capillary channel and nozzle are prepared by photoetching or hot press method, preferably MEMS
It is prepared by photoetching process.
The depth of the capillary channel is 10~50 microns, and width is 50~500 microns.
The lyophoby micro-valve is prepared using monolayer self-assembly method.
The contact angle of the lyophoby micro-valve and institute's extracting liq is at 100 ° or more.
With dimethyl silicone polymer (PDMS), polymethyl methacrylate or silicon thin film bonding above the capillary channel
To form closed flow.
Further include the actuating device of atmospheric pressure of adjustable driving air pressure, the actuating device of atmospheric pressure is connected to the air pressure and enters
Mouthful, for driving fluid to be flowed in the capillary channel.
A kind of adjustable lyophoby micro-valve type micro liquid extraction methods of liquid-taken amount, use the lyophoby micro-valve type micro liquid
Body extraction element, includes the following steps：
A certain amount of liquid is driven to be entered by the fluid inlet with the air pressure of the Opening pressure less than all lyophoby micro-valves
The capillary channel, between the main line and each branch intersection point shunting, fill up successively each intersection point to each lyophoby micro-valve it
Between branch flow channel, remaining liquid is along loop at the liquid inlet described in air pressure push back；
The pressure voltage and each intersection point of the amount of liquid, each lyophoby micro-valve that extract as needed are to the branch between each lyophoby micro-valve
The liquid capacity of road runner increases driving air pressure, and the lyophoby micro-valve that pressure voltage is less than driving air pressure is made to open, temporary in corresponding branch
Liquid towards spout and ejection.
Beneficial effects of the present invention：
It is prefilled before the blocking action realization liquid ejection that the present invention passes through lyophoby micro-valve, it is filled out by lyophoby micro-valve is temporary
Filling liquid body, then so that liquid is overcome the blocking action of lyophoby micro-valve by way of increasing pressure, it is sprayed by nozzle, to accurately carry
Lyophoby micro-valve is taken out to the micro liquid between split point in runner.Due to liquid loading by capillary channel branch size
And the circuitry number decision of liquid extraction is participated in, it can facilitate, flexibly, accurately processing volume is tens picoliters to tens nanoliters
Liquid.
It is an advantage of the current invention that admission space can be controlled by designing the accurate size of capillary channel, by lyophoby
The on-demand opening of lyophoby micro-valve is realized in the differentiation design of micro-valve pressure voltage, to achieve the purpose that volume is controllable, and it is extra
Liquid may return to liquid inlet recycling, the fine droplet of picoliters grade easy to implement, and control mode is simple.
Micro-valve is combined with micro- spray and realizes the adjustable picoliters grade liquid extraction of liquid-taken amount by the present invention, simple in structure, operation
Simplicity, good compatibility can be widely used for the accurate extraction operation of liquid in microfluidic control field.
Description of the drawings
Fig. 1 is the lyophoby micro-valve type micro liquid extraction apparatus structural schematic diagram of the embodiment of the present invention.
Fig. 2 is a specific embodiment of micro liquid extraction element of the present invention.
Fig. 3 a to Fig. 3 e are that the process of the lyophoby micro-valve type micro liquid extraction methods extracting liq of the embodiment of the present invention is shown
It is intended to.
Reference sign：
The liquid inlets 1- and the liquid entered herein,
2- air pressure inlets and the gas entered herein,
3- capillary channels,
4- lyophoby micro-valves,
5- nozzles,
6- branches,
7- matrixes.
Specific implementation mode
It elaborates below to embodiments of the present invention.It is emphasized that following the description is only exemplary,
The range being not intended to be limiting of the invention and its application.
Refering to fig. 1 to Fig. 3 e, in one embodiment, a kind of adjustable lyophoby micro-valve type micro liquid extraction dress of liquid-taken amount
It sets, including matrix 7 and the fluid inlet 1, air pressure inlet 2, lyophoby micro-valve 4, capillary channel and the nozzle that are formed in described matrix 7
5, the capillary channel includes being formed as the main line 3 of a loop and being connected in parallel between the main line 3 and the nozzle 5
Multiple branches 6, the fluid inlet 1 and the air pressure inlet 2 connect the main line 3, and each branch 6 is equipped with former based on lyophoby
The outlet of the lyophoby micro-valve 4 with setting pressure voltage of reason, each branch 6 connects the nozzle 5.Silicon, photoetching can be used in matrix 7
The materials such as glue, dimethyl silicone polymer (PDMS) or polymethyl methacrylate (PMMA) are made.
When work, liquid enters capillary channel from fluid inlet 1, is flowed in capillary channel under the effect of the pressure, and
Liquid inlet can be returned to, after liquid enters branch 6, since lyophoby acts at lyophoby micro-valve 4, flowing is hindered, a part
Liquid is temporarily stored in branch 6, and the liquid in main line 3 pushes back liquid inlet by pressure, improves driving pressure as needed at this time
Size, the lyophoby micro-valve 4 that all pressure voltages are less than driving pressure are opened, and the temporary liquid of place branch 6 sprays, big by pressure
The number that small control lyophoby micro-valve 4 is opened, to control the volume of extracting liq.
In some embodiments, the pressure voltage of the lyophoby micro-valve 4 on each branch 6 is different.It is of course also possible to design
Pressure voltage at partial branch 6 is identical.Since each branch 6 can keep in a certain amount of liquid, and the lyophoby of each branch 6 is micro-
4 pressure voltage of valve is different, and when driving pressure is more than the pressure voltage of respective branch 6, the liquid kept in respective branch 6 will pass through lyophoby
Therefore micro-valve 4 by adjusting the driving pressure of air pressure inlet 2, can extract the variable micro liquid of volume classification.
In a preferred embodiment, the multiple branch 6 abreast intersects vertically with the main line 3.Particularly, main line 3
Can being arranged to tool, there are two half round runner to be used as opposed end, constitutes loop by the way that two line flowing channels are connected, multiple
The connection of branch 6 is wherein on straight line runner.
The liquid inlet, air pressure inlet 2, capillary channel and nozzle 5 can be prepared by photoetching or hot press method, such as
It is prepared by MEMS photoetching processes.
In a preferred embodiment, the depth of the capillary channel is 10~50 microns, and width is 50~500 microns.
The preparation of monolayer self-assembly method can be used in the lyophoby micro-valve 4.
In a preferred embodiment, the contact angle of the lyophoby micro-valve 4 and institute's extracting liq is at 100 ° or more.
Dimethyl silicone polymer (PDMS), polymethyl methacrylate or silicon thin film key can be used above the capillary channel
It closes to form closed flow.
It is a specific embodiment of lyophoby micro-valve type micro liquid extraction apparatus of the present invention, wherein capillary flow shown in Fig. 2
Road is prepared with SU-8 photoetching processes, and lyophoby micro-valve 4 is by 1H, 1H, 2H, 2H- perfluoro decyl trichlorosilane monolayer self assembly works
Prepared by skill, be bonded with dimethyl silicone polymer (PDMS) film above runner, with closed flow.There are 10 branches in the present embodiment
6,50 microns of the capillary flow road width of each branch 6 is 10 microns deep, and the distance of intersection point to lyophoby micro-valve 4 is 50 microns, therefore can be carried
Take the liquid of 25~250 picoliters.
In further embodiments, a kind of lyophoby micro-valve type micro liquid extraction apparatus, in addition to including aforementioned any implementation
Further include the actuating device of atmospheric pressure (not shown) of adjustable driving air pressure, the actuating device of atmospheric pressure connection except the matrix 7 of example
To the air pressure inlet 2, for driving fluid to be flowed in the capillary channel.
Refering to Fig. 3 a to Fig. 3 e, in one embodiment, a kind of adjustable lyophoby micro-valve type micro liquid extraction of liquid-taken amount
Method is included the following steps using the lyophoby micro-valve type micro liquid extraction apparatus：
With the air pressure of the Opening pressure less than all lyophoby micro-valves 4 drive a certain amount of liquid by the fluid inlet 1 into
Enter the capillary channel, it is micro- to each lyophoby to fill up each intersection point successively for the intersection point shunting between the main line 3 and each branch 6
6 runner of branch between valve 4, remaining liquid is along loop at the liquid inlet described in air pressure push back；
The pressure voltage and each intersection point of the amount of liquid, each lyophoby micro-valve 4 that extract as needed are between each lyophoby micro-valve 4
The liquid capacity of 6 runner of branch increases driving air pressure, and the lyophoby micro-valve 4 that pressure voltage is less than driving air pressure is made to open, in corresponding branch
6 temporary liquid towards spout 5 simultaneously spray.
Refering to fig. 1 to Fig. 3 e, according to an embodiment of the invention, micro-valve and micro- spray is combined, the obstruction of lyophoby micro-valve 4 is passed through
Effect is realized prefilled before liquid sprays, then the blocking action of lyophoby micro-valve 4 is overcome by way of increasing pressure, by nozzle
5 spray, and 4 pressure voltage of lyophoby micro-valve of each branch 6 is different from, therefore it is micro- to control lyophoby by way of adjusting driving pressure
The quantity that valve 4 opens, the amount of liquid needed for grading extraction.The size of capillary channel determines the loadings of each branch 6, and connects
Liquid inlet, air pressure inlet 2 and nozzle 5, lyophoby micro-valve 4 are arranged on branch 6, and all branches 6 converge at nozzle 5, micro-valve
It is the 6 extractible amount of liquid of branch to the space between 6 intersection point of main line 3 and branch in runner.It is a certain amount of when extracting liq
Liquid enters capillary channel less than under the air pressure of 4 pressure voltage of lyophoby micro-valve driving at one by liquid inlet, is shunted in point of intersection,
Each intersection point is filled up successively to 6 runner of branch between micro-valve, remaining liquid pushes back liquid inlet by pressure, increases on demand drive at this time
Dynamic pressure makes the lyophoby micro-valve 4 that pressure resistance is less than driving pressure open, and the temporary liquid towards spout 5 of place branch 6 simultaneously sprays,
Complete the extraction of a liquid.
Capillary is entered by liquid inlet refering to lyophoby micro-valve type micro liquid extraction methods, liquid shown in Fig. 3 a to Fig. 3 e
Runner, gas are entered by air pressure inlet 2, and liquid is pushed to reach lyophoby micro-valve 4, this driving pressure should be less than all lyophoby micro-valves
4 opening pressure, since lyophoby micro-valve 4 hinders the flowing of liquid, liquid flows in capillary channel to fluid inlet 1, often
A branch 6 only has sub-fraction liquid and stays in the capillary channel between Heavenly Stems and Earthly Branches road intersection point and lyophoby micro-valve 4, increases driving at this time
Pressure, partially liq overcome the obstruction of lyophoby micro-valve 4, converge to the ejection of nozzle 5, and a micro liquid extraction is completed.
The above content is specific/preferred embodiment further description made for the present invention is combined, cannot recognize
The specific implementation of the fixed present invention is confined to these explanations.For those of ordinary skill in the art to which the present invention belongs,
Without departing from the inventive concept of the premise, some replacements or modification can also be made to the embodiment that these have been described,
And these are substituted or variant all shall be regarded as belonging to protection scope of the present invention.
Claims (12)
1. a kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount, which is characterized in that including matrix and be formed in
Fluid inlet, air pressure inlet, lyophoby micro-valve, capillary channel in described matrix and nozzle, the capillary channel include being formed as
The main line of one loop and the multiple branches being connected in parallel between the main line and the nozzle, the fluid inlet and described
Air pressure inlet connects the main line, and each branch road is equipped with the lyophoby micro-valve with setting pressure voltage based on lyophoby principle, respectively
The outlet of a branch connects the nozzle.
2. lyophoby micro-valve type micro liquid extraction apparatus as described in claim 1, which is characterized in that at least partly branch road
Lyophoby micro-valve pressure voltage it is different.
3. lyophoby micro-valve type micro liquid extraction apparatus as described in claim 1, which is characterized in that the multiple branch is simultaneously
Row ground intersects vertically with the main line.
4. lyophoby micro-valve type micro liquid extraction apparatus as claimed in claim 3, which is characterized in that the main line is arranged to
There are two half round runner for tool as opposed end, is connected by two line flowing channels by constitutes loop, the multiple branch connects
It is connected on wherein straight line runner.
5. such as Claims 1-4 any one of them lyophoby micro-valve type micro liquid extraction apparatus, which is characterized in that the stream
Body entrance, air pressure inlet, capillary channel and nozzle are prepared by photoetching or hot press method.
6. such as Claims 1-4 any one of them lyophoby micro-valve type micro liquid extraction apparatus, which is characterized in that the stream
Body entrance, air pressure inlet, capillary channel and nozzle are prepared by MEMS photoetching processes.
7. such as Claims 1-4 any one of them lyophoby micro-valve type micro liquid extraction apparatus, which is characterized in that the hair
The depth in thread road is 10~50 microns, and width is 50~500 microns.
8. such as Claims 1-4 any one of them lyophoby micro-valve type micro liquid extraction apparatus, which is characterized in that described to dredge
Liquid micro-valve is prepared using monolayer self-assembly method.
9. lyophoby micro-valve type micro liquid extraction apparatus as claimed in claim 7, which is characterized in that the lyophoby micro-valve with
The contact angle of institute's extracting liq is at 100 ° or more.
10. such as Claims 1-4 any one of them lyophoby micro-valve type micro liquid extraction apparatus, which is characterized in that described
Capillary channel top dimethyl silicone polymer (PDMS), polymethyl methacrylate or silicon thin film bonding are to form closing stream
Road.
11. such as Claims 1-4 any one of them lyophoby micro-valve type micro liquid extraction apparatus, which is characterized in that also wrap
The actuating device of atmospheric pressure of adjustable driving air pressure is included, the actuating device of atmospheric pressure is connected to the air pressure inlet, for driving stream
Body flows in the capillary channel.
12. a kind of adjustable lyophoby micro-valve type micro liquid extraction methods of liquid-taken amount, which is characterized in that using such as claim 1
To 11 any one of them lyophoby micro-valve type micro liquid extraction apparatus, include the following steps：
Drive a certain amount of liquid described in fluid inlet entrance with the air pressure of the Opening pressure less than all lyophoby micro-valves
Capillary channel, the intersection point shunting between the main line and each branch, fills up each intersection point between each lyophoby micro-valve successively
Branch flow channel, remaining liquid is along loop at the fluid inlet described in air pressure push back；
The pressure voltage and each intersection point of the amount of liquid, each lyophoby micro-valve that extract as needed are to the branch stream between each lyophoby micro-valve
The liquid capacity in road increases driving air pressure, and the lyophoby micro-valve that pressure voltage is less than driving air pressure is made to open, in the temporary liquid of corresponding branch
Body flows to nozzle and sprays.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610203354.5A CN105910847B (en) | 2016-04-01 | 2016-04-01 | A kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount and method |
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|---|---|---|---|
| CN201610203354.5A CN105910847B (en) | 2016-04-01 | 2016-04-01 | A kind of adjustable lyophoby micro-valve type micro liquid extraction apparatus of liquid-taken amount and method |
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| CN2625577Y (en) * | 2003-06-06 | 2004-07-14 | 中国石化胜利油田有限公司采油工艺研究院 | Automatic dispensing apparatus for microflow liquid |
| CN1311913C (en) * | 2004-10-28 | 2007-04-25 | 博奥生物有限公司 | Trace amount liquid jet system |
| CN100578228C (en) * | 2005-09-09 | 2010-01-06 | 博奥生物有限公司 | Minute quantity liquid precise distribution instrument and using method thereof |
| KR100963146B1 (en) * | 2010-02-26 | 2010-06-15 | (주)에쎈테크 | Proportional quantity control type hot-water supply system |
| US10271782B2 (en) * | 2012-09-03 | 2019-04-30 | Shimadzu Corporation | Liquid collecting apparatus and liquid collecting method |
| CN104571152A (en) * | 2015-01-20 | 2015-04-29 | 哈尔滨工业大学 | Liquid drop micro fluid control closed-loop regulation device based on microvalve |
| CN105278587A (en) * | 2015-10-26 | 2016-01-27 | 哈尔滨工业大学 | Multi-channel microfluidic pressure source |
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