CN108380254A - Microfluidic chip liquid drop generating means - Google Patents
Microfluidic chip liquid drop generating means Download PDFInfo
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- CN108380254A CN108380254A CN201810321522.XA CN201810321522A CN108380254A CN 108380254 A CN108380254 A CN 108380254A CN 201810321522 A CN201810321522 A CN 201810321522A CN 108380254 A CN108380254 A CN 108380254A
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- 239000007788 liquid Substances 0.000 title claims abstract description 90
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 10
- 230000001105 regulatory effect Effects 0.000 claims description 10
- 230000005484 gravity Effects 0.000 abstract description 4
- 239000012071 phase Substances 0.000 description 10
- 239000008346 aqueous phase Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000005220 pharmaceutical analysis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention provides a kind of microfluidic chip liquid drop generating means comprising：First liquid stream driving device, second liquid stream driving device and the micro-fluidic chip being arranged below the first liquid stream driving device and the second liquid stream driving device, first liquid stream driving device is connected to by first pipe with the first passage entrance on micro-fluidic chip, second liquid stream driving device is connected to by second pipe with the second channel entrance on micro-fluidic chip, the first microchannel is additionally provided on micro-fluidic chip, second microchannel and liquid outlet, first passage entrance is connected to by the first microchannel with second channel entrance, first microchannel is connected to by the second microchannel with liquid outlet again with the river outlet of second channel entrance.The present invention by liquid stream be driven through gravity drive, be not necessarily to external driving force, field of employment is unrestricted and drop formation speed is fast.
Description
Technical field
The present invention relates to microfluidic control technical fields, more specifically, are related to a kind of microfluidic chip liquid drop generation dress
It sets.
Background technology
A kind of extremely important mode that drop is manipulated as fluid, it is not only common but also significant.And micron and nanometer ruler
The drop of degree all plays irreplaceable role in terms of immunoassay, cell sorting, material package, drug intelligence release.
In recent years, unicellular drop technique is the fields such as genetic test, unicellular metabolin high flux screening, unicellular Pharmaceutical Analysis hair
Wave increasingly important role.
Exploitation of the micro-fluidic chip in drop formation field greatly improves the formation speed and controllability of drop.This
Outside, micro-fluidic chip can be obtained by massive duplication, and a grinding tool can make thousands of unified chips.Based on micro-
Fluidic chip technology has developed a variety of different drop formation designs and chip apparatus.But already present drop formation
Device has required high-accuracy syringe pump to drive.Therefore, it is limited to be operated in the laboratory of scientific research institutions more.How
Develop portable microfluidic chip liquid drop generating means so that this technology can work in the place of various needs, be this
Where the absorbed point of patent.
Invention content
In view of the above problems, the object of the present invention is to provide a kind of microfluidic chip liquid drop generating means, which uses
Gravity does not need additional device as driving force, and a large amount of drops of generation for capableing of fast and stable.
To achieve the goals above, the present invention is realized by technical solution below：
A kind of microfluidic chip liquid drop generating means, the drop formation device include：First liquid stream driving device, second
Liquid stream driving device and it is arranged micro-fluidic below the first liquid stream driving device and the second liquid stream driving device
Chip, the first liquid stream driving device are connected to by first pipe with the first passage entrance on the micro-fluidic chip, institute
The second liquid stream driving device is stated to be connected to the second channel entrance on the micro-fluidic chip by second pipe, it is described micro-fluidic
The first microchannel, the second microchannel and liquid outlet are additionally provided on chip, the first passage entrance is micro- logical by described first
Road is connected to the second channel entrance, and the river outlet of first microchannel and the second channel entrance passes through described the again
Two microchannels are connected to the liquid outlet.
Further, third microchannel is additionally provided on the micro-fluidic chip, the second channel entrance passes through described
Third microchannel connect to form confluence with first microchannel, and the end of first microchannel is hung down with the third microchannel
It is direct-connected to connect.
Further, two first microchannels, two first microchannels are provided on the micro-fluidic chip
It is arranged in the both sides of the third microchannel and the end of two first microchannels is vertical with the third microchannel connects
It connects so that the end of two first microchannels forms " ten " word cross aisle with the third microchannel.
Further, the first liquid stream driving device includes the first reservoir, and first reservoir passes through first
Frame is arranged in the top of the micro-fluidic chip.
Further, the second liquid stream driving device includes the second reservoir, and second reservoir passes through second
Frame is arranged in the top of the micro-fluidic chip.
Further, it is provided with the first regulating valve in the first pipe, the second adjusting is provided on the second pipe
Valve.
Further, first microchannel include the first straight channel being connect with the first passage entrance and with it is described
The S-shaped microchannel of first straight channel connection.
Further, second microchannel includes the snakelike microchannel being connect with the liquid outlet.
Further, second microchannel is diameter with far from described the close to one end of the second channel entrance
The half elliptic or cone that two feeder connections become larger.
Further, the solution placed in the first liquid stream driving device is placed in the second liquid stream driving device
Solution it is immiscible.
Compared with prior art, the present invention at least has the advantages that：
(1) liquid stream driving device of the invention is to be not necessarily to external driving force, especially whole device by gravity drive
High-accuracy syringe pump etc. is not all needed to drive, this, which allows for the device, to work in the place of various needs, be not limited to section
It grinds in the laboratory of institutes and is operated；
(2) present invention corresponds to for multiple and different liquid streams and designs multiple and different microchannels, and drop formation speed is fast, every point
Clock can be completed to be more than 500 drops；
(3) present invention can regulate and control flow velocity by adjusting regulating valve in the height and pipeline of liquid stream driving device
Degree, and then easily control drop formation speed；
(4) it is molten can to generate different sizes, heterogeneity for the design of the criss-crossing channels on micro-fluidic chip of the present invention
The drop of liquid and the online generation that can realize drop；
(5) the configuration of the present invention is simple, low manufacture cost are suitable for promoting.
To the accomplishment of the foregoing and related purposes, one or more aspects of the present invention includes being particularly described below especially
The feature pointed out.Certain illustrative aspects of the invention is described in detail in the following description and the annexed drawings.However, these aspects refer to
What is shown is only that some of the various ways in the principles of the present invention can be used.In addition, the present invention is intended to include it is all this
A little aspects and their equivalent.
Description of the drawings
It is of the invention by reference to the description below in conjunction with attached drawing, and with a fuller understanding of the present invention
Other purposes and result will be more clearly understood and understood.In the accompanying drawings：
Fig. 1 is the structural schematic diagram of the drop formation device of the embodiment of the present invention；
Fig. 2 is the structural schematic diagram of the first liquid stream driving device of the embodiment of the present invention；
Fig. 3 is the structural schematic diagram of the second liquid stream driving device of the embodiment of the present invention；
Fig. 4 is the structural schematic diagram of the micro-fluidic chip of the embodiment of the present invention.
Identical label indicates similar or corresponding feature or function in all the appended drawings.
Specific implementation mode
Hereinafter, specific embodiments of the present invention will be described in detail with reference to the accompanying drawings.
As shown in Figure 1, Figure 2, Fig. 3 and Fig. 4 jointly shown in, the invention discloses a kind of microfluidic chip liquid drop generating means,
It is driven in the first liquid stream driving device and the second liquid stream including the first liquid stream driving device, the second liquid stream driving device and setting
Micro-fluidic chip 3 below device.First liquid stream driving device includes the first reservoir 1, which passes through the one or three
Tripod (not shown) is arranged in the top of micro-fluidic chip 3.Second liquid stream driving device includes the second reservoir 2, this
Two reservoirs 2 are also disposed at the top of micro-fluidic chip 3 by the second tripod (not shown).It is set on micro-fluidic chip 3
It is equipped with first passage entrance 30 and second channel entrance 31, the first reservoir 1 is entered by first polymer hose 4 with first passage
Mouth 30 connects, and the second reservoir 2 is connect by second polymer hose 5 with second channel entrance 31.In the present embodiment, first
There are differences in height with micro-fluidic chip 3 for reservoir 1 and the second reservoir 2, therefore in the first reservoir 1 and the second reservoir 2
Liquid stream can be flowed on micro-fluidic chip 3 by gravity, without extrinsic motive drive, it is applied widely.For side
Just the flow stream velocity of the first reservoir 1 and the second reservoir 2 is controlled, the first regulating valve 6 is provided on first polymer hose 4,
The second regulating valve 7 is provided on second polymer hose 5.
The first microchannel 32, the second microchannel 33 and setting are provided on micro-fluidic chip 3 at 33 end of the second microchannel
The liquid outlet 34 at end.First passage entrance 30 is connect by the first microchannel 32 with second channel entrance 31, to realize
The liquid in the second reservoir of liquid pair 2 in one reservoir 1 is cut.In order to improve the effect of cutting, micro-fluidic chip 3
On further include third microchannel 35, one end of third microchannel 35 is connect with second channel entrance 31, third microchannel 35 it is another
One end is connect with the ending vertical of the first microchannel 32, can make the second reservoir of liquid pair 2 in the first reservoir 1 in this way
In liquid cutting speed it is most fast and cutting efficiency is best.It is furthermore preferred that being symmetrically arranged two in the both sides of third microchannel 35
The first microchannel of item 32, the end 320 of two article of first microchannel 32 is with 35 vertical connection of third microchannel so that two article
The end 320 of one microchannel 32 forms criss-crossing channels with third microchannel 35, so that the liquid in the first reservoir 1
Vertically the liquid in the second reservoir 2 can be cut from the both sides of third microchannel 35, further improve cutting
Speed, but also the drop smaller of cutting.
First microchannel 32 includes the first straight channel 321 being connect with first passage entrance 30, divides from the first straight channel 322
The U-shaped microchannel 322 of stream and the S-shaped microchannel 323 being connect with U-shaped microchannel 322.In the present embodiment, two it is first micro-
The first straight channel 320 on channel is overlapped to save manufacturing procedure, and the setting of the first straight channel 321 can allow liquid stream fast
Speed is flowed out from first passage entrance 30, and liquid stream is further separated by the first straight channel 321 into two U-shaped microchannels 322, then from
U-shaped microchannel 322 enters corresponding S-shaped microchannel 323, and the setting of S-shaped microchannel 323 then can make liquid stream flow over
Balance is progressivelyed reach in journey.The river outlet of one end and third microchannel 35 of second microchannel 33 and two the first microchannels 32 connects
It connects, the other end of the second microchannel 33 is connect with liquid outlet 34.Liquid in second reservoir 2 is third microchannel 35 and two
The river outlet of first microchannel 32 cuts into drop by the liquid in the first reservoir 1, and it is micro- logical that second is entered to after the completion of cutting
In road 33, the drop just cut is generally ellipse, in order to enable liquid stream is more smooth, the second microchannel 33 is micro- logical close to third
The one end in road 35 is set as diameter with the half elliptic or cone become larger far from third microchannel 35.Second is micro- logical
Road 33 includes the second straight channel 330 being connect with the river outlet of third microchannel 35 and two the first microchannels 32 and with second
The snakelike microchannel 331 that straight channel 330 connects, the end of snakelike microchannel 331 connect with liquid outlet 34, liquid stream and is cut
Drop is first flowed into the second straight channel 330, is entered back into snakelike microchannel 331, due to the presence of snakelike microchannel 331,
It can make the droplets mixing cut in the liquid in the first reservoir 1 and the second reservoir 2, disperse evenly, simultaneously
The drop time enough cut is also gived to go to stablize to reach balance.
In the microfluidic chip liquid drop generating means of application the present embodiment, in the first reservoir 1 and the second reservoir 2
Two kinds of immiscible liquid are respectively charged into, are such as packed into aqueous phase solution in the first reservoir 1, are packed into the second reservoir 2
Oil-phase solution.The first regulating valve 6 is opened, aqueous phase solution enters first by first polymer hose 4 from the first reservoir 1 and leads to
In road entrance 30, the flow of the first regulating valve 6 is adjusted according to actual needs in use in the first reservoir 1 of control
Flow stream velocity.Open the second regulating valve 7 again, oil-phase solution enters the from the second reservoir 2 by second polymer hose 5
In two feeder connections 31, the second regulating valve 7 is adjusted to control the flow stream velocity of oil-phase solution.Aqueous phase solution enters from first passage
Mouthfuls 30 have respectively entered in two the first microchannels 32, and the thereon is introduced into during flowing in the first microchannel 32
One straight channel 321 branch to again two U-shaped microchannels 322 this then into corresponding S-shaped microchannel 323 and in S-shaped
It is balanced in microchannel 323.Oil-phase solution is then entered from second channel entrance 33 in third microchannel 35.When two it is first micro- logical
When aqueous phase solution in road 32 meets with the oil-phase solution in third microchannel 35 at criss-crossing channels, aqueous phase solution is from two
Oil-phase solution is cut to generate the drop of oil phase in a direction perpendicular to oil-phase solution flowing.Oil phase after being cut
Drop liquid compatible with water is entered together in the second straight channel 330 on the second microchannel 33, is entered back into the second microchannel 33
On snakelike microchannel 331 in and wherein mixing disperse so that reach balance.The oil phase liquid being finally scattered in aqueous phase solution
It drops at the liquid outlet 34 of 331 end of snakelike microchannel and is collected, and then complete the generation and acquisition of drop.
Microfluidic chip liquid drop generating means according to the present invention are described in an illustrative manner above with reference to attached drawing.But
It, can also be it will be appreciated by those skilled in the art that for the microfluidic chip liquid drop generating means that aforementioned present invention is proposed
It does not depart from and makes various improvement on the basis of the content of present invention.Therefore, protection scope of the present invention should be wanted by appended right
The content of book is asked to determine.
Claims (10)
1. a kind of microfluidic chip liquid drop generating means, which is characterized in that the drop formation device includes：First liquid stream drives
Device, the second liquid stream driving device and setting are below the first liquid stream driving device and the second liquid stream driving device
Micro-fluidic chip, the first liquid stream driving device passes through the first passage entrance on first pipe and the micro-fluidic chip
Connection, the second liquid stream driving device are connected to by second pipe with the second channel entrance on the micro-fluidic chip, institute
It states and is additionally provided with the first microchannel, the second microchannel and setting second microchannel end on micro-fluidic chip and goes out liquid
Mouthful, the first passage entrance is connected to by first microchannel with the second channel entrance, first microchannel and
The river outlet of the second channel entrance is connected to by second microchannel with the liquid outlet again.
2. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that also set on the micro-fluidic chip
It is equipped with third microchannel, the second channel entrance connect to form remittance by the third microchannel with first microchannel
Stream, end and the third microchannel vertical connection of first microchannel.
3. microfluidic chip liquid drop generating means as claimed in claim 2, which is characterized in that be arranged on the micro-fluidic chip
Have two first microchannels, two articles of first microchannels be arranged the third microchannel both sides and two articles described
The end of one microchannel with third microchannel vertical connection so that the end of two first microchannels with it is described
Third microchannel forms " ten " word cross aisle.
4. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that the first liquid stream driving device
Including the first reservoir, first reservoir is arranged by first support in the top of the micro-fluidic chip.
5. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that the second liquid stream driving device
Including the second reservoir, second reservoir is arranged by second support in the top of the micro-fluidic chip.
6. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that be provided in the first pipe
First regulating valve is provided with the second regulating valve on the second pipe.
7. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that first microchannel include with
First straight channel of the first passage entrance connection and the S-shaped microchannel being connect with first straight channel.
8. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that second microchannel include with
The snakelike microchannel of the liquid outlet connection.
9. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that second microchannel is close to institute
The one end for stating second channel entrance is diameter with the half elliptic or cone become larger far from the second channel entrance.
10. microfluidic chip liquid drop generating means as described in claim 1, which is characterized in that the first liquid stream driving dress
Solution and the solution placed in the second liquid stream driving device for setting interior placement are immiscible.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810321522.XA CN108380254A (en) | 2018-04-11 | 2018-04-11 | Microfluidic chip liquid drop generating means |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810321522.XA CN108380254A (en) | 2018-04-11 | 2018-04-11 | Microfluidic chip liquid drop generating means |
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| CN108380254A true CN108380254A (en) | 2018-08-10 |
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ID=63073781
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| CN201810321522.XA Pending CN108380254A (en) | 2018-04-11 | 2018-04-11 | Microfluidic chip liquid drop generating means |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109078662A (en) * | 2018-09-12 | 2018-12-25 | 昆明理工大学 | A kind of two-phase laminated flow microdevice based on centrifugation with capillarity |
| CN111266140A (en) * | 2020-03-09 | 2020-06-12 | 厦门大学 | Oil-free sorting-direct injection-ICPMS single cell analysis system |
| CN111729699A (en) * | 2020-07-09 | 2020-10-02 | 墨卓生物科技(上海)有限公司 | Liquid drop generating mechanism for dPCR integrated micro-fluidic chip |
| CN111760600A (en) * | 2020-06-23 | 2020-10-13 | 深圳技术大学 | Microfluidic chip, preparation method thereof and cell sorting method |
| CN112033953A (en) * | 2019-06-03 | 2020-12-04 | 利多(香港)有限公司 | Micro-fluidic chip and application |
| CN112403539A (en) * | 2019-08-23 | 2021-02-26 | 无锡源清天木生物科技有限公司 | Micro-fluidic chip |
| CN113413934A (en) * | 2021-07-16 | 2021-09-21 | 安徽骆华生物科技有限公司 | Preparation method and application of cross flow focusing type droplet micro-fluidic chip |
| CN113457591A (en) * | 2021-07-07 | 2021-10-01 | 化学与精细化工广东省实验室 | Micro-channel reactor |
| CN114054105A (en) * | 2020-08-07 | 2022-02-18 | 无锡源清天木生物科技有限公司 | Micro-droplet quick sorting system |
| CN114222628A (en) * | 2019-06-03 | 2022-03-22 | 细胞快速道路有限公司 | Apparatus for sorting microfluidic particles |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109078662A (en) * | 2018-09-12 | 2018-12-25 | 昆明理工大学 | A kind of two-phase laminated flow microdevice based on centrifugation with capillarity |
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| CN111266140A (en) * | 2020-03-09 | 2020-06-12 | 厦门大学 | Oil-free sorting-direct injection-ICPMS single cell analysis system |
| CN111760600B (en) * | 2020-06-23 | 2021-05-25 | 深圳技术大学 | Microfluidic chip, preparation method thereof and cell sorting method |
| CN111760600A (en) * | 2020-06-23 | 2020-10-13 | 深圳技术大学 | Microfluidic chip, preparation method thereof and cell sorting method |
| CN111729699A (en) * | 2020-07-09 | 2020-10-02 | 墨卓生物科技(上海)有限公司 | Liquid drop generating mechanism for dPCR integrated micro-fluidic chip |
| CN114054105A (en) * | 2020-08-07 | 2022-02-18 | 无锡源清天木生物科技有限公司 | Micro-droplet quick sorting system |
| CN113457591A (en) * | 2021-07-07 | 2021-10-01 | 化学与精细化工广东省实验室 | Micro-channel reactor |
| CN113457591B (en) * | 2021-07-07 | 2024-04-16 | 墨格微流科技(汕头)有限公司 | Microchannel reactor |
| CN113413934A (en) * | 2021-07-16 | 2021-09-21 | 安徽骆华生物科技有限公司 | Preparation method and application of cross flow focusing type droplet micro-fluidic chip |
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