CN105902957A - 一种治疗胰腺囊肿的制剂 - Google Patents
一种治疗胰腺囊肿的制剂 Download PDFInfo
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Abstract
本发明提供了一种治疗胰腺囊肿的制剂，属于中药技术领域，所述制剂包括：柴胡、黄苓、山枝、大黄、厚朴、霍香、茵陈、金钱草、白芍、泽泻、莪术、黄芪、淡竹叶、土茯苓、山楂、玄胡、瓦楞子、鸡内金；本发明的制剂通过具有清热解毒，活血化瘀，软坚散结，渗湿利水的药物，起到干扰和破坏囊肿的炎性环境的作用，以达到治疗胰腺囊肿的目的，本发明的制剂，通过临床验证，治疗效果显著，能彻底治愈胰腺囊肿，同时避免了采用手术治疗囊肿带来的痛苦，治疗后无副作用，不易复发。
Description
技术领域
本发明属于中药技术领域，尤其是一种治疗胰腺囊肿的制剂。
背景技术
胰腺囊肿分先天性囊肿和获得性囊肿两种，其中先天性囊肿又叫真性囊肿，约占胰腺囊肿的10％，获得性囊肿又叫假性囊肿，约占全部胰腺囊肿的80％以上。真性囊肿的特点是在胰腺内壁有一层上衣衬托，然而当真性囊肿合并慢性炎症、感染时，上皮层也可能受到破坏而消失；假性胰腺囊肿通常是指在胰腺内或者胰腺周围的异常体液存留形成的囊腔，其囊壁由腹膜、网膜或炎性纤维结缔组织构成，囊壁内无上皮细胞衬托；假性胰腺囊肿又分为急性和慢性两类，急性通常认为是急性胰性积液，常见于急性胰腺炎或急性胰腺外伤后，由胰腺的自身消化和胰液的外渗引起，慢性胰腺囊肿是在慢性胰腺炎的基础上由胰管梗阻后破裂所致，大多为胰腺内囊肿。
囊肿，中医认为是气滞血瘀，湿浊缠绵，恶瘀内阻而形成积聚，因久痛致气血不和、情志失调、肝气郁结、致气血瘀滞，加之湿热稽留下焦，膀胱气化失合而得病。
在现有技术中，治疗胰腺囊肿多采用手术治疗，主要是内引流术、外引流术和囊肿及胰腺部分切除术。内引流术：①囊肿胃后壁吻合术，但该术式容易引起吻合口出血，可能与缝线过稀、假囊壁糜烂、假性动脉瘤形成破裂有关。②囊肿十二指肠吻合术，但该术容易发生十二指肠瘘，后果十分严重。③囊肿空肠吻合术，同样也存在吻合口出血的风险，导致感染一系列的并发症。外引流术：有出血、穿孔和感染的并发症。囊肿及胰腺部分切除术：对胰头部囊肿行胰腺切除时，由于炎症常累及临近大血管，所以手术危险性很大。
目前国内有研究治疗胰腺囊肿的中药配方，并取得了一定的成效，如申请号CN201410729961.6的发明《一种治疗假性胰腺囊肿的中药汤剂》公开了大黄，郁金，丹参，三棱，昆布，木香，莪术，蜈蚣，泽兰，柴胡，羚羊角，猫爪草，穿山甲，鸡骨草，枳实，素馨花，龙葵，白花蛇舌草，山慈姑，铃茵陈，天然牛黄，七叶莲的中药配方治疗假性胰腺囊肿。如申请号CN201510679076.6的发明《治疗重症急性胰腺炎后胰腺假性囊肿的药物及其制备方法》公开了党参、茯苓、陈皮、豆蔻、炒白术、薏苡仁、山药、炒麦芽、红花、穿山甲、丹参和鸡血藤的中药配方治疗重症急性胰腺炎后的假性胰腺囊肿。同时，中医疗法具有副作用小，抗复发率效果好，能稳定病情，不扩散的特点，使得其在胰腺囊肿领域得到了快速的应用和推广，但是，由于现有技术中的中医配方不合理，原料成分不恰当，导致中医治疗难以将胰腺囊肿彻底治愈，并且至今尚未发现能在短时间内彻底治愈胰腺囊肿的中药制剂出现。
发明内容
为了解决现有技术中存在的上述技术问题，本发明提供一种配方合理、无毒副作用、疗效快、成本低、能彻底治愈胰腺囊肿的制剂。
为了达到上述目的，本发明是这样实现的：一种治疗胰腺囊肿的制剂，以重量计，柴胡12-18克、黄苓12-18克、山枝12-18克、大黄2-10克、厚朴12-18克、霍香12-18克、丹参12-18克、金钱草24-36克、郁金12-18克、茵陈12-18克、黄连7-13克、白芍12-18克、泽泻12-18克、茯苓12-18克、白芥子12-18克、三棱12-18克、莪术12-18克、天冬12-18克、土茯苓15-25克、黄芪24-36克、海藻12-18克、淡竹叶7-13克、穿心莲12-18克、山楂12-18克、玄胡12-18克、青木香12-18克、瓦楞子12-18克、法夏7-13克、鸡内金15-25克。
进一步的，所述制剂由以下重量份的原料制成：柴胡13-17克、黄苓13-17克、山枝13-17克、大黄3-9克、厚朴13-17克、霍香13-17克、丹参13-17克、金钱草26-34克、郁金13-17克、茵陈13-17克、黄连8-12克、白芍13-17克、泽泻13-17克、茯苓13-17克、白芥子13-17克、三棱13-17克、莪术13-17克、天冬13-17克、土茯苓16-24克、黄芪26-34克、海藻13-17克、淡竹叶8-12克、穿心莲13-17克、山楂13-17克、玄胡13-17克、青木香13-17克、瓦楞子13-17克、法夏6-12克、鸡内金16-24克。
进一步，本发明中药原料最佳重量配比是：柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
一种治疗胰腺囊肿的制剂，其制备方法具体包括如下步骤：煎煮前准备，选取砂锅及饮用水，按比例称取药材，草本类药材在常温或者室温水中浸泡60-80分钟，果实块茎类药材在常温或者室温水中浸泡80-100分钟；煎煮，将浸泡好的药物用干净纱布过滤之后混合，煎煮两次，第一次加入原料重量的2-2.5倍的水，未沸前急火煎煮，沸后用小火保持微沸状态30-50分钟，用干净纱布过滤得药液，备用，药渣中第二次加入原料总重量的1.5-1.8倍水，未沸前急火煎煮，沸后用小火保持微沸状态10-30分钟，用干净纱布过滤得药液，将两次药液合并，既得本发明制剂；保存，冰箱冷藏箱内保存或放置阴凉通风处。
进一步，所述治疗胰腺囊肿的制剂是口服制剂，该口服制剂是中药汤剂。
用法与用量：煎水服用，每天三次，每次120毫升。
本发明采用柴胡等29味中草药制成治疗胰腺囊肿的制剂，原料药材可以分为草本类药材和果实块茎类药材，其中草本类药材包括：柴胡、黄苓、大黄、金钱草、穿心莲、淡竹叶。
果实块茎类药材：山枝、厚朴、法夏、土茯苓、郁金、莪术、三棱、丹参、青木香。
其中该制剂中，采用如下功效机理的中药成分配入，使得其能够对胰腺囊肿病变机理起到干扰，并且起到破坏囊肿炎症环境的作用：
山枝：【性味】性平，味苦涩，无毒。【归经】入肺，脾。大肠三经。【功能与主治】清热，生津止渴。治虚热心烦，口渴咽痛，泻痢后重，倦怠乏力。
青木香：【性味】辛、苦，寒。【归经】归肺、胃经。【功能与主治】平肝止痛，解毒消肿。用于眩晕头痛，胸腹胀痛，痈肿疔疮，蛇虫咬伤。
穿心莲：【性味】苦，寒。【归经】归心、肺、大肠、膀胱经。【功能与主治】清热解毒，凉血，消肿。用于感冒发热，咽喉肿痛，口舌生疮，顿咳劳嗽，泄泻痢疾，热淋涩痛，痈肿疮疡，毒蛇咬伤。
淡竹叶：【性味】甘、淡，寒。【归经】归心、胃、小肠经。【功能与主治】清热除烦，利尿。用于热病烦渴，小便赤涩淋痛，口舌生疮。
黄连：【性味】寒、苦。【归经】心、肝、脾、胆、胃、大肠。【功能与主治】清热燥湿，泻火解毒。用于：湿热痞满，呕吐吞酸，泻痢，黄疽，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疗疮；外治湿疹，湿疮，耳道流脓。
丹参：【性味】味苦，微寒。【归经】归心、肝经。【功能与主治】活血祛瘀，通经止痛，清心除烦，凉血消痈。用于胸痹心痛，脘腹胁痛，瘕瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
玄胡：【性味】辛；苦；温；无毒。【归经】肝、胃、心、肺、脾。【功能与主治】活血，散瘀，理气，止痛。
三棱：【性味】辛、苦，平。【归经】归肝、脾经。【功能与主治】破血行气，消积止痛。用于症瘕痞块，瘀血经闭，食积胀痛。
法夏：【性味】辛、温。【归经】归脾、胃、肺经。【功能与主治】燥湿化痰。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛。
泽泻：【性味】味甘、淡，性寒。【归经】归肾、膀胱经。【功能与主治】利水渗湿，泄热，化浊降脂。用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高脂血症。
柴胡：【性味】味辛、苦，性微寒。【归经】归肝、胆、肺经。【功能与主治】和解表里，疏肝解郁，升阳举陷，退热截疟。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子宫脱垂，脱肛。
海藻：【性味】苦、咸，寒。【归经】归肝、胃、肾经。【功能与主治】软坚散结，消痰，利水。用于瘿瘤，瘰疬、睾丸肿痛，痰饮水肿。
综上所述，本发明的有益效果在于：本发明的制剂通过具有清热解毒，活血化瘀，软坚散结，渗湿利水的功效的药物进行组合，使得制剂具有干扰胰腺囊肿病变的发生，并且具有破坏囊肿炎性环境的作用，达到治疗胰腺囊肿的目的，本发明的制剂，其治疗效果显著，能彻底治愈胰腺囊肿，同时避免了采用手术治疗囊肿带来的痛苦，治疗后无副作用，不易复发，且操作简便，同时所选用的中药原料均容易获得，且价格低廉。
具体实施方式
下面对本发明的具体实施方式作进一步详细的说明，但本发明并不局限于这些实施方式，任何在本实施例基本精神上的改进或代替，仍属于本发明权利要求所要求保护的范围。
实施例一：中药汤剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡12克、黄苓12克、山枝12克、大黄2克、厚朴12克、霍香12克、丹参12克、金钱草24克、郁金12克、茵陈12克、黄连7克、白芍12克、泽泻12克、茯苓12克、白芥子12克、三棱12克、莪术12克、天冬12克、土茯苓15克、黄芪24克、海藻12克、淡竹叶7克、穿心莲12克、山楂12克、玄胡12克、青木香12克、瓦楞子12克、法夏7克、鸡内金15克。
其制备方法的步骤包括：煎煮前准备，选取砂锅及饮用水，按比例称取药材，草本类药材在常温或者室温水中浸泡60分钟，果实块茎类药材在常温或者室温水中浸泡80分钟；煎煮，将浸泡好的药物用干净纱布过滤之后混合，煎煮两次，第一次加入原料重量的2倍的水，未沸前急火煎煮，沸后用小火保持微沸状态30分钟，用干净纱布过滤得药液，备用，药渣中第二次加入原料总重量的1.5倍水，未沸前急火煎煮，沸后用小火保持微沸状态10分钟，用干净纱布过滤得药液，将两次药液合并，既得本发明制剂；保存，冰箱冷藏箱内保存或放置阴凉通风处。
服用方法：每天三次，每次120毫升。
实施例二：中药汤剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
其制备方法的步骤包括：煎煮前准备，选取砂锅及饮用水，按比例称取药材，草本类药材在常温或者室温水中浸泡70分钟，果实块茎类药材在常温或者室温水中浸泡90分钟；煎煮，将浸泡好的药物用干净纱布过滤之后混合，煎煮两次，第一次加入原料重量的2.2倍的水，未沸前急火煎煮，沸后用小火保持微沸状态40分钟，用干净纱布过滤得药液，备用，药渣中第二次加入原料总重量的1.6倍水，未沸前急火煎煮，沸后用小火保持微沸状态20分钟，用干净纱布过滤得药液，将两次药液合并，既得本发明制剂；保存，冰箱冷藏箱内保存或放置阴凉通风处。
服用方法：每天三次，每次120毫升。
实施例三：中药汤剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡18克、黄苓18克、山枝18克、大黄10克、厚朴18克、霍香18克、丹参18克、金钱草36克、郁金18克、茵陈18克、黄连13克、白芍18克、泽泻18克、茯苓18克、白芥子18克、三棱18克、莪术18克、天冬18克、土茯苓25克、黄芪36克、海藻18克、淡竹叶13克、穿心莲18克、山楂18克、玄胡18克、青木香18克、瓦楞子18克、法夏13克、鸡内金25克。
其制备方法的步骤包括：煎煮前准备，选取砂锅及饮用水，按比例称取药材，草本类药材在常温或者室温水中浸泡80分钟，果实块茎类药材在常温或者室温水中浸泡100分钟；煎煮，将浸泡好的药物用干净纱布过滤之后混合，煎煮两次，第一次加入原料重量的2.5倍的水，未沸前急火煎煮，沸后用小火保持微沸状态50分钟，用干净纱布过滤得药液，备用，药渣中第二次加入原料总重量的1.8倍水，未沸前急火煎煮，沸后用小火保持微沸状态30分钟，用干净纱布过滤得药液，将两次药液合并，既得本发明制剂；保存，冰箱冷藏箱内保存或放置阴凉通风处。
服用方法：每天三次，每次120毫升。
实施例四：丸剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡12克、黄苓12克、山枝12克、大黄2克、厚朴12克、霍香12克、丹参12克、金钱草24克、郁金12克、茵陈12克、黄连7克、白芍12克、泽泻12克、茯苓12克、白芥子12克、三棱12克、莪术12克、天冬12克、土茯苓15克、黄芪24克、海藻12克、淡竹叶7克、穿心莲12克、山楂12克、玄胡12克、青木香12克、瓦楞子12克、法夏7克、鸡内金15克。
其制备方法的步骤包括：粉碎，将原料按配方量分别打磨成粉末，然后混合均匀；炼蜜，拌药粉：将蜂蜜按照与药粉1∶1的比例量放入铜锅中加水煮沸，使其溶化并适当稀释，通过50或65目的筛网以滤除杂质，滤液返回铜锅中继续加热，搅拌不断去沫，当出现浅黄色有光泽的翻腾的均匀细气泡出现，用手捻有粘性，当两手指分开时无白丝出现时即可，加入约四分之三的药粉，不停地翻炒挤压，此时温度高，不能用手触碰，待搅拌成面团后，可试着用手挤压面团，如果觉得沾手，就用备份的药粉撒上一点，继续挤压摔打直到不粘手为止；趁热，做蜜丸：将面团搓成条状，然后小段小段的用手或者小刀截下来，用制丸板按制成1000粒丸剂。
服用方法为：口服，一日三次，每次2-3粒，饭前服用。
实施例五：胶囊剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
其制备方法的步骤包括：将配方量原料按比例打磨成粉末，加入医学上使用的辅料混合均匀，过筛，制作成胶囊1000粒。
服用方法为：温水吞服，一日二次，每次2-3粒。
实施例六：片剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡12克、黄苓12克、山枝12克、大黄2克、厚朴12克、霍香12克、丹参12克、金钱草24克、郁金12克、茵陈12克、黄连7克、白芍12克、泽泻12克、茯苓12克、白芥子12克、三棱12克、莪术12克、天冬12克、土茯苓15克、黄芪24克、海藻12克、淡竹叶7克、穿心莲12克、山楂12克、玄胡12克、青木香12克、瓦楞子12克、法夏7克、鸡内金15克。
其制备方法的步骤包括：将配方量原料分别打磨成粉末，加入医学上使用的辅料混合均匀，过筛，通过压片机直接压制成片，压制1000片。
服用方法为：温水吞服，一日二次，每次2-3片。
实施例七：片剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡18克、黄苓18克、山枝18克、大黄10克、厚朴18克、霍香18克、丹参18克、金钱草36克、郁金18克、茵陈18克、黄连13克、白芍18克、泽泻18克、茯苓18克、白芥子18克、三棱18克、莪术18克、天冬18克、土茯苓25克、黄芪36克、海藻18克、淡竹叶13克、穿心莲18克、山楂18克、玄胡18克、青木香18克、瓦楞子18克、法夏13克、鸡内金25克。
其制备方法的步骤包括：将配方量原料分别打磨成粉末，加入医学上使用的辅料混合均匀，加入粘合剂和润滑剂，搅拌均匀制成软材，通过10目的筛网进行造粒，将所得的湿粒经过烘箱进行干燥，通过压片机压制成片，压制1000片。
服用方法为：温水吞服，一日二次，每次2-3片。
实施例八：冲剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
其制备方法的步骤包括：浸膏的制备，称取配方量原料，置于5000ml的圆底烧瓶中，加入原料总重量10倍的水，浸泡2h，之后水浴回流两次，每次1h，抽取滤液，在4000rpm的离心机中离心30min后得到提取液，在60℃的水浴下旋蒸浓缩得到浸膏，备用；制粒，在浸膏中加入按1∶3的比例加入乳糖混合均匀后制成软材，以手握成团，轻压即散为标准；制粒，将混合均匀的软材通过50目筛制粒，50℃烘干1h后整粒，整粒后60℃下烘干1h得成品，包装成1000包。
服用方法为：100-150ml的温水搅拌，一日三次，每次1包。
实施例九：冲剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
其制备方法的步骤包括：浸膏的制备，称取配方量原料，置于砂锅中，加入原料总重量5倍的水，浸泡2h后，急火煎煮90min，干净滤布过滤得滤液，重复上述操作两次之后，将三次所得滤液混合，在60℃的水浴下旋蒸浓缩得到浸膏，备用；制粒，在浸膏中加入按1∶3的比例加入乳糖混合均匀后制成软材，以手握成团，轻压即散为标准；制粒，将混合均匀的软材通过50目筛制粒，50℃烘干1h后整粒，整粒后60℃下烘干1h得成品，包装成1000包。
服用方法为：100-150ml的温水搅拌，一日三次，每次1包。
实施例十：糖浆剂
一种治疗胰腺囊肿的制剂，由以下重量配比的原料制成：柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
其制备方法的步骤包括：浸膏的制备，称取配方量原料，打磨成粗粉并混合均匀，先加入药粉量1倍量的溶剂使药粉充分润湿，搅匀后密闭放置40-50min，将润湿的药物粉末均匀装入渗漉器中，保持松紧一致，不断往渗漉器中添加医学上适宜的溶剂，使其自上而下的渗透过药材并保证溶剂始终浸没药粉表面，浸渍放置28-32h，使溶剂充分渗透，渗漉完成后，将药粉进行压榨，将渗漉液和压榨液合并，添加乙醇至规定浓度后静置，过滤即得到提取液，在60℃水浴下旋蒸浓缩得到浸膏；糖浆制备，将乳糖与水按1∶2的比例混合均匀，加热煮沸过滤即可；将所得浸膏与糖浆按1∶1的比例混合均匀，按每瓶250ml的量包装。
服用方法为：一日三次，每次15ml。
本发明无毒无害，服用安全，现设计试验例来验证治疗胰腺囊肿的中药配方的毒性和功效。
1、毒性试验例：
1.1、材料
1.1.1、药物：采用实施例一，实施例三的中药制剂。
1.1.2、试验对象：选取身体状况健康的小白鼠50只，雌雄各半，体重10-15g，在人工照明12h、通风条件良好情况下饲养观察3d，随机分为5组，10只/组，其中一组为空白对照试组，给药前12h和给药后4小时禁止进食，但不禁水。
1.2、方法：3d过后，除了空白组分别对另外4组小白鼠灌服剂量分别为200ml/kg、400ml/kg、600ml/kg、800ml/kg的实施例一的制剂，观察7d。
1.3、结果：连续观察7d，全部小白鼠均健活且全部小白鼠的精神、食欲、分泌物、呼吸、眼等方面均未观察到异常，将实验小鼠和对照组小鼠经剖解后，各组织器官无明显感官不同，取心、肝、脾、肺、肾及肠作病理切片也无明显不同，增大剂量，同样的方法灌服实施例三的制剂，全部小鼠仍然健活，且与对照组比较无异常，说明该中药制剂对小鼠安全无毒。
2、功效试验例：本发明服用安全，操作简便，疗效显著，是能彻底治愈胰腺囊肿的有效药物，并为临床资料所证明，本发明有关临床资料如下：
2.1典型病例：
2.1.1、金光华：39岁，男，于2014年11月5日到我诊所就诊。CT示胰腺囊肿3.2*2.2，上腹部与背部疼痛.服用上方15付后觉得疼痛症状减轻，继服用两个月后囊肿消失。
2.1.2、郑金钰：40岁，男，2015年1月10日到我诊所诊治。来时CT示胰腺囊肿有2厘米大小，有疼痛，腹胀，现在感觉胃胀，1年前经常开始犯胰腺炎，胆原性胰腺炎，胰腺位置感觉很不舒服。服用上方70付后囊肿完全消失了。
2.1.3、张春雨：72岁，于2015年3月12日到我诊所就诊。患者食欲不振，前几天痛的厉害，腹胀，五天不大便，这两天好些了，前年底做的CT胰尾有白果大的囊肿。服用上方15天后疼痛症状消失，两个月后囊肿消失。
2.1.4、要菱：53岁，男，于2016年3月16日到我诊所诊治，之前确诊是渗出性胰腺炎，引发囊肿，囊肿有39mmx29mm，象鸡蛋那么大，后来做了一个穿刺引流，囊肿里面液体很少。服用上方一个月以后，囊肿彻底消失了。
2.1.5、付松洲：40岁，女，10月份因胰腺炎住院，出院后CT检查胰腺有0.6公分小囊肿，目前症状：吃饭有饱胀感，腹部隐痛。于2015年12月份开始服用上方，一个月后复查，囊肿没有了，目前就是腹部偶尔有腹痛。
本发明人随访至今，患者身体一直健康，胰腺及周边部位无异常。
Claims (7)
1.一种治疗胰腺囊肿的制剂，其特征在于：以重量计，柴胡12-18克、黄苓12-18克、山枝12-18克、大黄2-10克、厚朴12-18克、霍香12-18克、丹参12-18克、金钱草24-36克、郁金12-18克、茵陈12-18克、黄连7-13克、白芍12-18克、泽泻12-18克、茯苓12-18克、白芥子12-18克、三棱12-18克、莪术12-18克、天冬12-18克、土茯苓15-25克、黄芪24-36克、海藻12-18克、淡竹叶7-13克、穿心莲12-18克、山楂12-18克、玄胡12-18克、青木香12-18克、瓦楞子12-18克、法夏7-13克、鸡内金15-25克。
2.根据权利要求1所述的治疗胰腺囊肿的制剂，其特征在于：以重量计，柴胡13-17克、黄苓13-17克、山枝13-17克、大黄3-9克、厚朴13-17克、霍香13-17克、丹参13-17克、金钱草26-34克、郁金13-17克、茵陈13-17克、黄连8-12克、白芍13-17克、泽泻13-17克、茯苓13-17克、白芥子13-17克、三棱13-17克、莪术13-17克、天冬13-17克、土茯苓16-24克、黄芪26-34克、海藻13-17克、淡竹叶8-12克、穿心莲13-17克、山楂13-17克、玄胡13-17克、青木香13-17克、瓦楞子13-17克、法夏6-12克、鸡内金16-24克。
3.根据权利要求1所述的治疗胰腺囊肿的制剂，其特征在于：以重量计，柴胡15克、黄苓15克、山枝15克、大黄6克、厚朴15克、霍香15克、丹参15克、金钱草30克、郁金15克、茵陈15克、黄连10克、白芍15克、泽泻15克、茯苓15克、白芥子15克、三棱15克、莪术15克、天冬15克、土茯苓20克、黄芪30克、海藻15克、淡竹叶10克、穿心莲15克、山楂15克、玄胡15克、青木香15克、瓦楞子15克、法夏9克、鸡内金20克。
4.根据权利要求1或2或3所述的治疗胰腺囊肿的制剂，其特征在于：所述制剂为口服制剂。
5.根据权利要求4所述的治疗胰腺囊肿的制剂，其特征在于：所述的口服制剂为中药汤剂。
6.根据权利要求1或2或3所述的治疗胰腺囊肿的制剂，其特征在于：所述制剂的制备方法：称取药材，分两次煎煮，第一次加入原料总重量的2-2.5倍的水，未沸前急火煎煮，沸后用小火保持微沸状态30-50分钟，过滤，滤液备用，药渣中第二次加入原料总重量的1.5-1.8倍的水，未沸前急火煎煮，沸后用小火保持微沸状态10-30分钟，过滤，混合两次滤液即可。
7.根据权利要求6所述的治疗胰腺囊肿的制剂，其特征在于：所述制剂的制备方法还包括，将药材原料分为草本类药材和果实块茎类药材，其中草本类药材在常温或者室温水中浸泡60-80分钟，果实块茎类药材在常温或者室温水中浸泡80-100分钟。
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