CN105902815A - 一种治疗治疗肾性高血压的中药汤剂 - Google Patents

一种治疗治疗肾性高血压的中药汤剂 Download PDF

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CN105902815A
CN105902815A CN201610357910.4A CN201610357910A CN105902815A CN 105902815 A CN105902815 A CN 105902815A CN 201610357910 A CN201610357910 A CN 201610357910A CN 105902815 A CN105902815 A CN 105902815A
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renal hypertension
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李旭东
左凯
魏森
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Abstract

本发明公开了一种治疗肾性高血压的中药汤剂，包括以下重量份数的原料药：稀莶草10‑13份、夏枯草8‑12份、钩藤6‑9份、蜀漆4‑8份、青木香6‑10份、杜仲5‑8份、茺蔚子10‑12份、虎尾轮根10‑15份、地龙3‑5份、刺五加6‑8份、徐长卿7‑9份、黄苓6‑10份、山楂8‑12份、淫羊藿10‑12份、半夏6‑8份、白芍6‑9份、麦冬8‑10份、生地6‑9份、豇豆8‑10份、益母草3‑6份、蜂斗菜5‑9份、苦参6‑9份、肾经草6‑10份、昆布8‑11份。本发明具有滋阴养血、平肝化瘀、降压平逆的功效，能有效治疗肾性高血压，疗程短，见效快、治疗率高。

Description

一种治疗治疗肾性高血压的中药汤剂
技术领域
本发明涉及中药领域，具体涉及一种治疗肾性高血压的中药汤剂。
背景技术
直接因肾脏疾病引起的高血压称为肾性高血压，约占成人高血压的5～10％，是继发性高血压的主要组成部分。其中肾动脉狭窄导致肾缺血引起的高血压独成一类，称肾血管性高血压，在整个肾性高血压中所占比例尚不及一半。肾脏疾病影响血压升高的因素很多，如水钠潴留导致的血容量增加，肾素-血管紧张素系统作用系统增加，肾内降压物质如前列腺素、缓激肽分泌减少，活性减弱；交感神经兴奋性增高，致使全身小动脉痉挛；可交换钠与肾素关系异常等。目前，治疗肾性高血压以西医为主，针对肾性高血压的发病机制，在药物选择方面，则凡能减少肾素释放或能抑制血管紧张素转换酶，或能扩张肾动脉，改善肾脏供血供氧的药物，以及减少血容量的药物，均可起到降低肾性高血压的作用。但这种方式对药物依赖性强，一旦停药很容易反复。
发明内容
为弥补现有技术的不足，本发明提供一种治愈率高，复发性小的治疗肾性高血压的中药汤剂。
本发明是通过如下技术方案实现的：
一种治疗肾性高血压的中药汤剂，其特殊之处在于：包括以下重量份数的原料药：稀莶草10-13份、夏枯草8-12份、钩藤6-9份、蜀漆4-8份、青木香6-10份、杜仲5-8份、茺蔚子10-12份、虎尾轮根10-15份、地龙3-5份、刺五加6-8份、徐长卿7-9份、黄苓6-10份、山楂8-12份、淫羊藿10-12份、半夏6-8份、白芍6-9份、麦冬8-10份、生地6-9份、豇豆8-10份、益母草3-6份、蜂斗菜5-9份、苦参6-9份、肾经草6-10份、昆布8-11份。
本发明的一种治疗肾性高血压的中药汤剂的制备方法，其特征在于：包括以下步骤：将原料药洗净，加其重8-10倍的水在75-85℃煎煮三次，合并煎液，煎煮时间为15-25min。
本发明的优选配方是，一种治疗肾性高血压的中药汤剂，其特征在于：包括以下重量份数的原料药：稀莶草12份、夏枯草10份、钩藤8份、蜀漆6份、青木香8份、杜仲6份、茺蔚子10份、虎尾轮根12份、地龙3份、刺五加8份、徐长卿8份、黄苓8份、山楂10份、淫羊藿10份、半夏6份、白芍8份、麦冬10份、生地8份、豇豆9份、益母草5份、蜂斗菜8份、苦参6份、肾经草8份、昆布10份。
本发明中各原料药的作用如下：
稀莶草：辛苦微寒，入肝、心经。祛风湿，通经络，解毒。用于风湿痹痛、筋骨疼痛、腰膝无力，痈疮肿毒、风疹湿疹、高血压。
夏枯草：辛、苦，寒。归肝、胆经。清肝泻火，明目，散结消肿。用于目赤肿痛，目珠夜痛，头痛眩晕，瘰疬，瘿瘤，乳痈，乳癖，乳房胀痛。
钩藤：味甘，性凉。归肝、心包经。息风定惊，清热平肝。用于肝风内动，惊痫抽搐，高热惊厥，感冒夹惊，小儿惊啼，妊娠子痫，头痛眩晕。
蜀漆：苦辛，温，有毒。入手、足厥阴经。除痰，截疟，消症瘕积聚。
青木香：辛、苦，寒。归肝、胃经。平肝止痛，解毒消肿。用于眩晕头痛，胸腹胀痛，痈肿疔疮，蛇虫咬伤。
杜仲：味辛，平。入肾经。补肝肾，治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，高血压、安胎的功效。
茺蔚子：辛、苦，微寒。归心包、肝经。活血调经，清肝明目。用于月经不调，经闭痛经，目赤翳障，头晕胀痛。
虎尾轮根：味甘，性温，无毒。入肺、胃、肾三经。理气，化痰，益肾。治心胃气痛，痰饮咳嗽，肾虚遗精。
地龙：热病惊狂、小儿惊风、咳喘、头痛目赤、咽喉肿痛、小便不通、风湿关节疼痛，半身不遂等症。外用涂丹毒、漆疮等症。
刺五加：味辛；苦；微甘；性温。归肝经；肾经。祛风湿；补肝肾；强筋骨；活血脉。主风寒湿痹；腰膝疼痛；筋骨痿软；小数点儿行迟；体虚赢弱；跌打损伤；骨折；水肿；脚气；阴下湿痒。
徐长卿：辛，温。肝、胃经。有祛风，化湿，止痛，止痒的功效。用于风湿痹痛，胃痛胀满，牙痛，腰痛，跌扑伤痛，风疹、湿疹。
黄苓：味苦，性寒。归肺、胆、脾、大肠、小肠经。清热燥湿，泻火解毒，止血，安胎。用于湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。
山楂：酸、甘，微温。归脾、胃、肝经。消食健胃，行气散瘀，化浊降脂。用于肉食积滞，胃脘胀满，泻痢腹痛，瘀血经闭，产后瘀阻，心腹刺痛，胸痹心痛，疝气疼痛，高脂血症。焦山楂消食导滞作用增强。用于肉食积滞，泻痢不爽。
淫羊藿：味辛、甘，性温，归肝、肾经，体轻气雄，可升可降。具有补肾壮阳、祛风除湿、强健筋骨的功效。主治肾虚阳痿、遗精早泄、精冷不育、尿频失禁、肾虚喘咳、腰膝酸软、筋骨挛急、风湿痹痛、麻木拘挛、半身不遂、四肢不仁、更年期高血压、小淋沥、喘咳等。
半夏：味辛，性温，有毒，归肺、脾、胃经，有良好的燥湿化痰和降逆止呕作用.现代药理研究表明：半夏块茎含有挥发油、少量脂肪、淀粉、烟碱、生物碱等，其水煎液有镇咳、祛痰、解除支气管平滑肌痉挛作用，并能抑制呕吐中枢而止呕。
白芍：苦，酸，微寒。归肝，脾经。平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。
麦冬：养阴生津，润肺清心。
用于肺燥干咳，虚痨咳嗽，津伤口渴，心烦失眠，内热消渴，肠燥便秘，咽白喉。
养阴生津，润肺止咳：用于肺胃阴虚之津少口渴、干咳咯血；心阴不足之心悸易惊及热病后期热伤津液等证。
生地：甘、苦，寒。归心、肝、肾经。清热凉血，养阴生津。清热、生津、润燥、滑肠、破瘀、生新、止痛、调经、金疮瘀、凉血、止血。
豇豆：味甘、性平。能健脾开胃、利尿除湿。用于脾胃虚弱、食少便溏；妇女脾虚带下，或湿热尿浊，小便不利。
益母草：性微寒，味苦辛。功效具有活血调经，祛瘀止痛，利尿消肿，清热解毒；临床主治月经不调、痛经、闭经、胎漏难产、胞衣不下、产后血晕、瘀血腹痛、跌打损伤、肾病水肿、小便不利、尿血、痈肿疮疡。
蜂斗菜：苦辛，凉。解毒祛瘀。治扁桃体炎，痈肿疔毒，毒蛇咬伤。
苦参：味苦，性寒。归心、肝、胃、大肠、膀胱经。用于热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风，外治滴虫性阴道炎。
肾经草：味甘；微苦；性平。壮腰补肾；清热利水；解毒。主肾虚腰痛；遗精；阳痿；白带；热淋；毒蛇咬伤；疮疖肿毒。
昆布：味咸，性寒。归肝，胃、肾经。消痰软坚散结，利水消肿。用于瘿瘤，瘰疬，睾丸肿痛，痰饮水肿。
本发明的有益效果是：本发明以多味中药为原料，科学配伍，各原料药之间协同作用，具有滋阴养血、平肝化瘀、降压平逆的功效，能有效治疗肾性高血压，疗程短，见效快、治疗率高，值得推广。
具体实施方式
实施例1
中药组份：稀莶草10g、夏枯草8g、钩藤6g、蜀漆4g、青木香6g、杜仲5g、茺蔚子10g、虎尾轮根10g、地龙3g、刺五加6g、徐长卿7g、黄苓6g、山楂8g、淫羊藿10g、半夏6g、白芍6g、麦冬8g、生地6g、豇豆8g、益母草3g、蜂斗菜5g、苦参6g、肾经草6g、昆布8g。
制备工艺：将原料药洗净，加其重8倍的水在85℃煎煮三次，合并煎液，煎煮时间为15min。每日一剂，早、晚各服一次，7天一个疗程。
实施例2
中药组份：稀莶草12g、夏枯草10g、钩藤8g、蜀漆6g、青木香8g、杜仲6g、茺蔚子10g、虎尾轮根12g、地龙3g、刺五加8g、徐长卿8g、黄苓8g、山楂10g、淫羊藿10g、半夏6g、白芍8g、麦冬10g、生地8g、豇豆9g、益母草5g、蜂斗菜8g、苦参6g、肾经草8g、昆布10g。
制备工艺：将原料药洗净，加其重8倍的水在75℃煎煮三次，合并煎液，煎煮时间为25min。每日一剂，早、晚各服一次，7天一个疗程。
实施例3
中药组份：稀莶草13g、夏枯草12g、钩藤9g、蜀漆8g、青木香10g、杜仲8g、茺蔚子12g、虎尾轮根15g、地龙5g、刺五加8g、徐长卿9g、黄苓10g、山楂12g、淫羊藿12g、半夏8g、白芍9g、麦冬10g、生地9g、豇豆10g、益母草6g、蜂斗菜9g、苦参9g、肾经草10g、昆布11g。
制备工艺：将原料药洗净，加其重10倍的水在85℃煎煮三次，合并煎液，煎煮时间为25min。每日一剂，早、晚各服一次，7天一个疗程。
实施例4：临床观察
（1）一般资料
本发明人于2014年至今对400例患者进行临床观察治疗，治愈369人，有效10人，总有效率高达94%。
（2）治疗方法：每日一剂，早、晚各服一次，7天一个疗程。
（3）疗效评定标准
治愈：症状体征完全消失；
有效：症状体征较减轻；
无效：症状体征与治疗前无改善。
（4）典型病例：
魏某某，女，42岁，河南人，患有肾性高血压，于2014年6月开始服用本发明的中药，每日一剂，早、晚各服一次， 7天一个疗程，两个疗程后血压下降，趋于平稳，继续服用本发明的中药两个疗程后痊愈停药。
姜某某，女，38岁，山东人，患有肾性高血压，于2015年4月开始服用本发明的中药，每日一剂，早、晚各服一次， 7天一个疗程，三个疗程后血压下降，趋于平稳，继续服用本发明的中药两个疗程后痊愈停药。

Claims (3)

1.一种治疗肾性高血压的中药汤剂，其特征在于：包括以下重量份数的原料药：稀莶草10-13份、夏枯草8-12份、钩藤6-9份、蜀漆4-8份、青木香6-10份、杜仲5-8份、茺蔚子10-12份、虎尾轮根10-15份、地龙3-5份、刺五加6-8份、徐长卿7-9份、黄苓6-10份、山楂8-12份、淫羊藿10-12份、半夏6-8份、白芍6-9份、麦冬8-10份、生地6-9份、豇豆8-10份、益母草3-6份、蜂斗菜5-9份、苦参6-9份、肾经草6-10份、昆布8-11份。
2.根据权利要求1所述的一种治疗肾性高血压的中药汤剂，其特征在于：包括以下重量份数的原料药：稀莶草12份、夏枯草10份、钩藤8份、蜀漆6份、青木香8份、杜仲6份、茺蔚子10份、虎尾轮根12份、地龙3份、刺五加8份、徐长卿8份、黄苓8份、山楂10份、淫羊藿10份、半夏6份、白芍8份、麦冬10份、生地8份、豇豆9份、益母草5份、蜂斗菜8份、苦参6份、肾经草8份、昆布10份。
3.根据权利要求1或2所述的一种治疗肾性高血压的中药汤剂的制备方法，其特征在于：包括以下步骤：将原料药洗净，加其重8-10倍的水在75-85℃煎煮三次，合并煎液，煎煮时间为15-25min。
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关于加强广防己等6种药材及其制剂监督管理的通知: "《关于加强广防己等6种药材及其制剂监督管理的通知》", 5 August 2004 *

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