CN105902449A - Chinese wampee leaf extract, preparing method thereof and application thereof in wash supplies - Google Patents
Chinese wampee leaf extract, preparing method thereof and application thereof in wash supplies Download PDFInfo
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- CN105902449A CN105902449A CN201610447604.XA CN201610447604A CN105902449A CN 105902449 A CN105902449 A CN 105902449A CN 201610447604 A CN201610447604 A CN 201610447604A CN 105902449 A CN105902449 A CN 105902449A
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- clausenae lansii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
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Abstract
The invention relates to the field of plant application research, in particular to a Chinese wampee leaf extract, a preparing method thereof and the application thereof in wash supplies. The Chinese wampee leaf extract is extracted from seedless Chinese wampee leaves with the microwave-assisted dynamic backflow technique, and can be added to wash supplies as an ingredient to make soap, shower gel, sanitizer, mosquito repellent and miliaria lotion. The method has the advantages that extraction process is simple, and operation is easy; the permeability of plant cell walls is improved through microwave assistance, the rate that effective constituents dissolving out of cells is increased, extraction efficiency is improved, and extraction time is shortened; the seedless Chinese wampee leaf extract contains constituents for inducing sweat to dispel heat and resisting toxin and bacteria, and application range is widened by applying the seedless Chinese wampee leaf extract to wash supplies.
Description
Technical field
The present invention relates to plant application research field, be specially a kind of Folium clausenae lansii extract and preparation method thereof and protect washing
Application in articles for use.
Background technology
Yunan seedless wampee, Yunan County, Guangdong Province special product, owing to Yunan seedless wampee elite stand is in Yunan, add that Yunan has
The weather of uniqueness, edaphic condition, the water resource of high-quality, so that Yunan seedless wampee is seedless with it, fruit big, meat thickness, succulence, color
Fresh, delicious, without slag, sweet acid is moderate, peel is thin, the solid soft feature of sarcocarp yellow-white, meat and transcendent, be number China
Treasure in ten kinds of Clausena lansium (Lour.) Skeels kinds.The clump of collection generation bunch is all had on arteries and veins below the sprout of Clausena lansium (Lour.) Skeels, floral axis, rachis, petiole and tender leaf
Shape undercoat and becoming mildewed, savory.Imparipinnate leaf alternate；The long 4-8mm of petiolule；Vanelets 5-13,1 piece of top maximum, to
Under taper into, avette or ellipticity lanceolar, long 6-13cm, wide 2.5-6cm, the sharp point of tip or short tapering, base portion width wedge shape,
Asymmetric, limit is shallow wavy or has shallow cognate.The feature of Folium clausenae lansii: Folium clausenae lansii blade is oblong, the back side has the gland of projection
Body, blade face is then covered with transparent oil drop.Its branch and leaf band fragrance, rub broken after the fragrance that sends richer.The filemot fruit of Clausena lansium (Lour.) Skeels, in
Ovum shape is spherical, and pubescence is draped over one's shoulders on surface, can be edible, and wampee fruit tree is fragrant and sweet good to eat, and effect of helpful digestion.The merit of Folium clausenae lansii
Effect: Folium clausenae lansii induces sweat heat radiation；Promoting the circulation of QI and reducing phlegm；Diuresis；Removing toxic substances.The main epidemic febrile disease of Folium clausenae lansii is generated heat；Epidemic encephalitis；Malaria；Cough phlegm dyspnea；Gastral cavity abdomen
Pain；Rheumatic arthralgia；General edema with yellowish skin；Dysuria；Pyretic toxicity scabies；Snake bite and insect sting.
Chinese patent storehouse discloses a kind of method utilizing double-aqueous phase system and ultrasonic integrated extraction Folium clausenae lansii total flavones
(CN201510116170.0)；First Folium clausenae lansii is pulverized by described method, adds certain density isopropanol and ammonium sulfate is water-soluble
Liquid forms double-aqueous phase system, and with total flavones in supersound extraction Folium clausenae lansii, described method designs on the basis of single factor experiment result
Orthogonal test, preferably goes out the extracting factor of total flavones；Optimum extraction condition is defined as ammonium sulfate concentrations 310mg/mL, and 40%
Aqueous isopropanol, ultrasonic time 20min, solid-liquid ratio 1: 40；The method of the present invention is easy and simple to handle, shortens extraction time, effectively
Improve extraction efficiency.
Chinese patent storehouse discloses the preparation method (CN201410274121.5) of a kind of Folium clausenae lansii extract, by inciting somebody to action
Raw material is cleaned, and dries, with low-carbon alcohols as extractant, and ultrasonic echography, concentrate, Folium clausenae lansii extract is prepared in drying.The present invention with
Folium clausenae lansii is raw material, uses ultrasonic wave added organic solvent method to extract Folium clausenae lansii active component, with the life that content in Folium clausenae lansii is more
Alkaloids is index, and the content of the alkaloid in the Folium clausenae lansii extract prepared is high；The preparation method of the present invention is simple, the cycle
Short, tremendous contribution is made in the comprehensive utilization for food fresh keeping, the exploitation of natural antiseptic agent and Folium clausenae lansii.
Folium clausenae lansii in state-owned bigger storage, and have the highest medical value, as heat radiation of inducing sweat, sterilization, promoting the circulation of QI and reducing phlegm,
Diuresis, removing toxic substances, adopt how to extract Folium clausenae lansii extract and the most carefully develop Folium clausenae lansii extract be value
The problem that must study.
Summary of the invention
For the problems referred to above, it is an object of the invention to provide a kind of Folium clausenae lansii extract and preparation method thereof and protect use washing
Application in product, uses the dynamic technique of backflow of microwave-assisted to extract Folium clausenae lansii extract from seedless wampee leaf, and Folium clausenae lansii extracts
Thing can add in washing product as a kind of dispensing, specifically can be made into fancy soap, bath gel, handwashing liquid, mosquito-repellent water, prickly heat liquid etc.
Product.
To achieve these goals, the present invention uses below scheme
According to the first aspect of the invention, a kind of Folium clausenae lansii extract, it is the active material admixture in Folium clausenae lansii, bag
Include alkaloid, polysaccharide, flavonoid glycoside, phenols, aminoacid, volatile oil, coumarin, terpenoid.
Preferably, described Folium clausenae lansii is Yunan seedless wampee leaf.
According to the second aspect of the invention, the preparation method of a kind of Folium clausenae lansii extract, it comprises the following steps:
(1) Folium clausenae lansii is cleaned, oven drying at low temperature at 35-45 DEG C, dry Folium clausenae lansii is pulverized, cross 60-80 mesh sieve afterwards；
(2) under microwave environment, with ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Huang
Skin leaf residue and solution A；Wherein, the mass ratio of dry Folium clausenae lansii and ethanol is 1:8-15, and temperature is 18-30 DEG C, and extraction time is
0.5-1.2h, extracts 1-3 time；
(3) under microwave environment, with 5%HCl-ethanol as extracting solution, use dynamic technique of backflow to extract, divide after extraction
From, obtain Folium clausenae lansii residue and solution B；Wherein, the mass ratio of dry Folium clausenae lansii and 5%HCl-ethanol is 1:8-12, and temperature is 18-
30 DEG C, extraction time is 0.5-1.2h, extracts 1-3 time；；
(4) under microwave environment, with petroleum ether as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain
Folium clausenae lansii residue and solution C；Wherein, the mass ratio of dry Folium clausenae lansii and petroleum ether is 1:6-10, and temperature is 18-30 DEG C, during extraction
Between be 0.5-1.2h, extract 1-3 time；
(5) by solution A, solution B, solution C mix homogeneously, solution D is obtained；
(6) solution D employing is concentrated in vacuo, isolates extracting solution, obtain the Folium clausenae lansii extract of paste；
(7) Folium clausenae lansii extract of paste is dried, i.e. obtain the Folium clausenae lansii extract of powder, Folium clausenae lansii extract
Water content is less than 1%.
Preferably, step (2), step (3) and step (4) use machine power force solution backflow.
Preferably, in step (2), step (3) and step (4), isolation technics is for filtering.
Preferably, in step (2), step (3) and step (4), microwave frequency is 6000-10000 megahertz.
Preferably, step (7) uses Freeze Drying Technique.
According to the third aspect of the invention we, it is provided that the application of a kind of Folium clausenae lansii extract, described Folium clausenae lansii extract conduct
A kind of dispensing is added in washing product.
Preferably, Folium clausenae lansii extract is applied to hand cleaning class, anophelifuge class, class of taking a shower, prevents and treats washing of miliaria class and protect
In articles for use.
Preferably, a kind of shower class cosmetic combinations containing Folium clausenae lansii extract, by weight, including following components:
Folium clausenae lansii extract 3-6 part, shower class surfactant 3-12 part, anti-sensitizer 0.5-2 part, whitening agent 2.5-6 part, wetting agent 2-
12 parts, potassium hydroxide 0.03-0.2 part, thickening agent 0.1-0.3 part, emulsifying agent 1.5-5.8 part, preservative 0.2-1 part, deionization
Water 40-80 part.
Preferably, described shower class surfactant be weight part ratio be (1-1.5): (1.5-3): the monoalkyl of (1-3)
Polyoxyethylenated alcohol phosphate ester potassium, lauryl alcohol phosphate ester and the mixture of sodium cocoyl glycinate.
Preferably, described anti-sensitizer be weight part ratio be (2-4): the Flos Matricariae chamomillae extract of (1.5-3) and bisabolol
Mixture.
Preferably, described whitening agent be weight part ratio be (1-2.5): (2-4): (0.8-1.6): the Citrus of (0.5-2.4)
The mixture of extract, endothelin antagonist, Radix Rhodiolae extracting solution and Radix Puerariae extract.
Preferably, described wetting agent be weight part ratio be (3-10): (1-5): (0.4-3): the glycerol of (0.5-3), Semen Maydis
The mixture of propylene glycol, pyrrolidone sodium carboxylate and trehalose.
Preferably, described thickening agent is xanthan gum.
Preferably, described emulsifying agent be weight part ratio be (1-3): (1-3): (0.5-3): the glycerol stearate of (0.2-2)
Ester/PEG-100 stearate, spermol cetylate/Pyrusussuriensis smooth cetylate/Pyrusussuriensis smooth olive oil acid esters, stereth-
The mixture of 21 and PEG-60 Span60s.
Preferably, described preservative be weight part ratio be (1-3): the propyl hydroxybenzoate of (1-4), sodium benzoate mixture.
Folium clausenae lansii is containing acid amide (neoclausenamide) in new Clausena lansium (Lour.) Skeels, different new Clausena lansium (Lour.) Skeels lactams
(isoneoclausenamide), Clausena lansium (Lour.) Skeels lactams (clausenamide), ring Clausena lansium (Lour.) Skeels lactams
(cyclocaausenamide), a kind of new lactams and ε-valerolactam (ε-valerolactam), high Clausena lansium (Lour.) Skeels lactams
(homoclausenamide) and ξ-Clausena lansium (Lour.) Skeels lactams (ξ-clausenamide), Coumarins compound print Clausena lansium (Lour.) Skeels lactone
(indicolactone), anistree Clausena lansium (Lour.) Skeels lactone (anisolactone), 2 ", 3 "-epoxy anise Clausena lansium (Lour.) Skeels lactone (2 ", 3 "-
epoxyanisolactone).Aerial parts terpene alcohol (lansiol) i.e. 3 beta-hydroxy-23 Han Triterpenoids Clausena lansium (Lour.) Skeels, 24,24-trimethyls
Lanostane-9 (11), 25-diene [3 β-hydroxy-23,24,24-trime-thyllanosta-9 (11), 25-diene],
Clausena lansium (Lour.) Skeels acid imide (lansimide) etc..Effect: heat radiation of inducing sweat；Promoting the circulation of QI and reducing phlegm；Diuresis；Removing toxic substances.Main epidemic febrile disease is generated heat；Epidemic encephalitis；Malaria
Disease；Cough phlegm dyspnea；Epigastric pain；Rheumatic arthralgia；General edema with yellowish skin；Dysuria；Pyretic toxicity scabies；Snake bite and insect sting.
The invention has the beneficial effects as follows: extraction process flow process is simple, easily operates；Plant cell is increased by microwave-assisted
The permeability of wall, accelerates the speed of effective ingredient dissolution cell, improves extraction efficiency, shortens extraction time；Seedless wampee leaf carries
Taking in thing containing inducing sweat the compositions such as heat radiation, antitoxin sterilization, be applied in washing product by seedless leaf Clausena lansium (Lour.) Skeels extract, expanding should
Use scope.
Detailed description of the invention
For the problems referred to above, it is an object of the invention to provide a kind of Folium clausenae lansii extract and preparation method thereof and protect use washing
Application in product, uses the dynamic technique of backflow of microwave-assisted to extract Folium clausenae lansii extract from seedless wampee leaf, and Folium clausenae lansii extracts
Thing can add in washing product as a kind of dispensing, specifically can be made into fancy soap, bath gel, handwashing liquid, mosquito-repellent water, prickly heat liquid etc.
Product.
To achieve these goals, the present invention uses below scheme
According to the first aspect of the invention, a kind of Folium clausenae lansii extract, it is the active material admixture in Folium clausenae lansii, bag
Include alkaloid, polysaccharide, flavonoid glycoside, phenols, aminoacid, volatile oil, coumarin, terpenoid.
Preferably, described Folium clausenae lansii is Yunan seedless wampee leaf.
According to the second aspect of the invention, the preparation method of a kind of Folium clausenae lansii extract, it comprises the following steps:
(1) Folium clausenae lansii is cleaned, oven drying at low temperature at 35-45 DEG C, dry Folium clausenae lansii is pulverized, cross 60-80 mesh sieve afterwards；
(2) under microwave environment, with ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Huang
Skin leaf residue and solution A；Wherein, the mass ratio of dry Folium clausenae lansii and ethanol is 1:8-15, and temperature is 18-30 DEG C, and extraction time is
0.5-1.2h, extracts 1-3 time；
(3) under microwave environment, with 5%HCl-ethanol as extracting solution, use dynamic technique of backflow to extract, divide after extraction
From, obtain Folium clausenae lansii residue and solution B；Wherein, the mass ratio of dry Folium clausenae lansii and 5%HCl-ethanol is 1:8-12, and temperature is 18-
30 DEG C, extraction time is 0.5-1.2h, extracts 1-3 time；；
(4) under microwave environment, with petroleum ether as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain
Folium clausenae lansii residue and solution C；Wherein, the mass ratio of dry Folium clausenae lansii and petroleum ether is 1:6-10, and temperature is 18-30 DEG C, during extraction
Between be 0.5-1.2h, extract 1-3 time；
(5) by solution A, solution B, solution C mix homogeneously, solution D is obtained；
(6) solution D employing is concentrated in vacuo, isolates extracting solution, obtain the Folium clausenae lansii extract of paste；
(7) Folium clausenae lansii extract of paste is dried, i.e. obtain the Folium clausenae lansii extract of powder, Folium clausenae lansii extract
Water content is less than 1%.
Preferably, step (2), step (3) and step (4) use machine power force solution backflow.
Preferably, in step (2), step (3) and step (4), isolation technics is for filtering.
Preferably, in step (2), step (3) and step (4), microwave frequency is 6000-10000 megahertz.
Preferably, step (7) uses Freeze Drying Technique.
According to the third aspect of the invention we, it is provided that the application of a kind of Folium clausenae lansii extract, described Folium clausenae lansii extract conduct
A kind of dispensing is added in washing product.
Preferably, Folium clausenae lansii extract is applied to hand cleaning class, anophelifuge class, class of taking a shower, prevents and treats washing of miliaria class and protect
In articles for use.
Preferably, a kind of shower class cosmetic combinations containing Folium clausenae lansii extract, by weight, including following components:
Folium clausenae lansii extract 3-6 part, shower class surfactant 3-12 part, anti-sensitizer 0.5-2 part, whitening agent 2.5-6 part, wetting agent 2-
12 parts, potassium hydroxide 0.03-0.2 part, thickening agent 0.1-0.3 part, emulsifying agent 1.5-5.8 part, preservative 0.2-1 part, deionization
Water 40-80 part.
Preferably, described shower class surfactant be weight part ratio be (1-1.5): (1.5-3): the monoalkyl of (1-3)
Polyoxyethylenated alcohol phosphate ester potassium, lauryl alcohol phosphate ester and the mixture of sodium cocoyl glycinate.
Preferably, described anti-sensitizer be weight part ratio be (2-4): the Flos Matricariae chamomillae extract of (1.5-3) and bisabolol
Mixture.
Preferably, described whitening agent be weight part ratio be (1-2.5): (2-4): (0.8-1.6): the Citrus of (0.5-2.4)
The mixture of extract, endothelin antagonist, Radix Rhodiolae extracting solution and Radix Puerariae extract.
Preferably, described wetting agent be weight part ratio be (3-10): (1-5): (0.4-3): the glycerol of (0.5-3), Semen Maydis
The mixture of propylene glycol, pyrrolidone sodium carboxylate and trehalose.
Preferably, described thickening agent is xanthan gum.
Preferably, described emulsifying agent be weight part ratio be (1-3): (1-3): (0.5-3): the glycerol stearate of (0.2-2)
Ester/PEG-100 stearate, spermol cetylate/Pyrusussuriensis smooth cetylate/Pyrusussuriensis smooth olive oil acid esters, stereth-
The mixture of 21 and PEG-60 Span60s.
Preferably, described preservative be weight part ratio be (1-3): the propyl hydroxybenzoate of (1-4), sodium benzoate mixture.
Microwave auxiliary extraction technology:
Microwave extracting is to utilize the effect of electromagnetic field to make some organic components in solid or semi-solid material and matrix
Efficiently separate, and a kind of separation method analyzing the script compound state of object can be kept.Microwave refers to that frequency is 300,000,000
The conspicuous electromagnetic wave to 300 gigahertzs.
The mechanism of microwave extracting can be analyzed in terms of following 3:
1. microwave radiation process is that frequency electromagnetic waves penetrates spe medium arrival microtubule fasolculus within material and glandular cell's system
Process.Owing to absorbing microwave energy, the temperature of cell interior will rise rapidly, so that the pressure of cell interior exceedes cell
Wall expands the ability that can bear, and result cell rupture, its interior effective ingredient freely flows out, and dissolves at a lower temperature
In spe medium.By further filtering and separating, required extract can be obtained.
2. electromagnetic field produced by microwave can accelerate what the molecule being extracted component was spread to solid liquid interface by solid interior
Speed.Such as, during with water as solvent, under the effect of microwave field, hydrone is changed into excited state by high-speed rotation state, and this is
A kind of high-octane labile state.Now hydrone or vaporization are to strengthen the driving force of extracted component, or release is come from
The unnecessary energy of body returns to ground state, and the energy discharged will be passed to the molecule of other materials, to accelerate its warm-up movement, thus
The molecule shortening extracted component is diffused to the time of solid liquid interface by solid interior, and result makes extraction rate improve several times, and energy
Reduce extraction temperature, ensure the quality of extract to greatest extent.
3. connecting with the frequency dependence of molecule rotation due to the frequency of microwave, therefore microwave energy is a kind of by ion migration and idol
Extremely son rotates and causes the non-ionising radiation energy of molecular motion, when it acts on molecule, can promote the rotational motion of molecule,
If molecule has certain polarity, instantaneous polarization can be produced under the effect of microwave field, and make with the speed of 24.5 hundred million times/s
Reversal campaign, thus produce the vibration of key, tear and interparticle friction and collision, and it is quickly generated substantial amounts of heat energy,
Promote cell rupture, make Cell sap overflow and diffuse in solvent.In microwave extracting, the difference absorbing microwave ability can make base
Some component in some region of body material or extraction system is heated by selectivity, so that being extracted material from matrix or body
System separates, enters into and have in the extractant that less dielectric constant, microwave absorption capacity are relatively poor.
Dynamically reflux, extract, technology:
Reflux extraction is with volatile organic solvent extraction material compositions such as ethanol, and leachate is added thermal distillation, its
Middle volatile solvent is cooled again after distillating, and repeating to flow back to leach in container to extract raw material, so going round and beginning again, until effectively becoming
Divide reflux, extract, method completely.Circumfluence method extracting solution heated time in evaporation boiler is longer, therefore is not suitable for being heated and subjects to brokenly
The leaching of bad material composition.
The dynamically improvement of reflux, extract, technology reflux extraction the most, uses machine power to make solution and material extract
Journey does relative motion, expands feed liquid contact surface, improve extraction ratio.
Technology be concentrated in vacuo:
Being concentrated in vacuo: under the induction of indirect steam and the suction of separator fine vacuum, the material being concentrated and secondary steam
Vapour tangentially enters separator with speed faster.Vacuum technique saves nutritional labeling and the fragrance of raw material.
It is concentrated in vacuo and there is lot of advantages.Liquid substance under fluidized state the evaporation of solvent quickly, its boiling point is because of pressure
And change, pressure increases, the elevation of boiling point, and pressure is little, and boiling point reduces.Such as milk is under 101kPa, and boiling point is 100 DEG C, and
Under vacuum 82.7～90.6KPa, boiling point is only 45～55 DEG C.Owing to evaporating at a lower temperature,.Simultaneously as material is not
Affected by high temperature, it is to avoid the destruction of thermally labile component and loss, preferably saved nutritional labeling and the fragrance of raw material.Special
It is not the materials such as some aminoacid, flavonoid, phenol, biostearin, can prevent from being heated and destroying.And some saccharides, protein, really
The material that the viscosity such as glue, phlegmatic temperament is bigger, low-temperature evaporation can prevent material coking.
Freeze Drying Technique:
The substantially temperature less than 0 DEG C that is dried of product is carried out, and i.e. carries out when product freezes, until after
Phase, in order to reduce the remaining water content of product further, just allow the temperature that product rises to more than 0 DEG C, but it is usually no more than 40
℃.Lyophilization is exactly containing large quantity of moisture material, carries out cooling in advance and is frozen into solid, then makes under conditions of vacuum
Water vapour directly distils out, and in the left ice shelf when freezing of material itself, therefore its dried constancy of volume, loose many
Hole is heat to be absorbed when distillation.Cause the decline of product self-temperature and the rate of sublimation that slows down, in order to increase rate of sublimation, contracting
Short drying time, it is necessary to product is suitably heated.Whole being dried is carried out at a lower temperature.
Lyophilization has the advantage that (1) lyophilization is carried out at low temperatures, and therefore the material for many thermal sensitivitys is special
The most applicable.As protein, microorganism etc will not occur degeneration or lose biologos.Therefore pharmaceutically obtain widely should
With；(2), when being dried at low temperatures, some volatile ingredients loss in material is the least, is suitable for some chemical productss, medicine and food
Product are dried；(3) in freezing dry process, the growth of microorganism and the effect of enzyme cannot be carried out, and therefore can keep original property
Dress；(4) owing to being dried when freezing, therefore volume is almost unchanged, maintains original structure, will not occur dense
Contracting phenomenon；(5) dried material is loose porous, in spongy, dissolves rapid and complete after adding water, and recovers original the most immediately
Character；(6) carrying out under vacuo due to dry, oxygen is few, and therefore some oxidizable materials are protected；(7) dry
The dry moisture content that can get rid of more than 95-99%, makes dried product can preserve for a long time and will not go bad.Therefore, lyophilization is current
It is widely used in medical industry, food industry, scientific research and other departments.
Folium clausenae lansii is odd number winglike compound leaf, lobule 5-13 sheet, many shrinkages, and broken, yellow green is to bottle green, and complete person is wealthy
Avette or ovum shape is oval, and gather tiny translucent oil drop and thin pubescence, long 4-13cm, wide 2-5cm, tip anxious the sharpest or short gradually
Point, base portion wedge shape is to circular, anisopleual, wavy to the shallow crenation of Ye Quanyuan or shallow, slightly warp, and vein is recessed in blade face,
Protruding in the back side, petiolule is by pubescence, and long 2-4mm, matter is crisp.Gas is fragrant, and mildly bitter flavor is pungent.Microscopical identification leaf cross section: upper epidermis
Cell is deltiod or rectangle, by horny layer；Lower epidermis cell is less, has most pore and nonglandular hair.Palisade tissue is 1-2
Row cell；Spongy tissue closes most calcium oxalate cluster crystal and minority prismatic crystal.Master pulse paper tube Shu Zhouren formula, pericyclic fiber bundle is yellowish
Color.Intermittent arrangement is circlewise.Mesophyll tissue there is large-scale secretory cell (diameter 40-200 μm) be dispersed in.[br] powder characteristics: yellow
Green.1. calcium oxalate cluster crystal is more, and corner angle are the most blunt, diameter 15-35 μm；Also there is minority prism of calcium oxalate；2. nonglandular hair finger-like is extremely
Conico-acuminate, diameter 30-50 μm, long 70-240 μm；3. epidermal surface is seen in polygon, and pore mostly is infinitive, minority
For ring type, subsidiary cell 4-6 is individual；4. pericyclic fiber wall is thicker, diameter 30-40 μm, around parenchyma cell have containing oxalic acid bunch
Brilliant；5. wood fiber outer wall is wavy, and cell is slightly larger, diameter 40-70 μm；6. conduit mostly is reticulate pattern and screw thread, diameter 60-100 μm.
Folium clausenae lansii is containing acid amide (neoclausenamide) in new Clausena lansium (Lour.) Skeels, different new Clausena lansium (Lour.) Skeels lactams
(isoneoclausenamide), Clausena lansium (Lour.) Skeels lactams (clausenamide), ring Clausena lansium (Lour.) Skeels lactams
(cyclocaausenamide), a kind of new lactams and ε-valerolactam (ε-valerolactam), high Clausena lansium (Lour.) Skeels lactams
(homoclausenamide) and ξ-Clausena lansium (Lour.) Skeels lactams (ξ-clausenamide), Coumarins compound print Clausena lansium (Lour.) Skeels lactone
(indicolactone), anistree Clausena lansium (Lour.) Skeels lactone (anisolactone), 2 ", 3 "-epoxy anise Clausena lansium (Lour.) Skeels lactone (2 ", 3 "-
epoxyanisolactone).Aerial parts terpene alcohol (lansiol) i.e. 3 beta-hydroxy-23 Han Triterpenoids Clausena lansium (Lour.) Skeels, 24,24-trimethyls
Lanostane-9 (11), 25-diene [3 β-hydroxy-23,24,24-trime-thyllanosta-9 (11), 25-diene],
Clausena lansium (Lour.) Skeels acid imide (lansimide) etc..
Effect of Folium clausenae lansii: heat radiation of inducing sweat；Promoting the circulation of QI and reducing phlegm；Diuresis；Removing toxic substances.Main epidemic febrile disease is generated heat；Epidemic encephalitis；Malaria；Cough expectorant
Breathe heavily；Epigastric pain；Rheumatic arthralgia；General edema with yellowish skin；Dysuria；Pyretic toxicity scabies；Snake bite and insect sting.
For the technical scheme making those skilled in the art be better understood from the application, come below in conjunction with embodiment
Technical scheme is clearly and completely described, it is clear that described embodiment is only the part of the application
Embodiment, based on the embodiment in the application, those of ordinary skill in the art are obtained under not making creative work premise
The every other embodiment obtained, all should belong to the scope of the application protection.
Embodiment 1
A kind of preparation method of Folium clausenae lansii extract, it comprises the following steps:
(1) Folium clausenae lansii is cleaned, oven drying at low temperature at 35-45 DEG C, dry Folium clausenae lansii is pulverized, cross 60-80 mesh sieve afterwards；
(2) under microwave environment, with ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Huang
Skin leaf residue and solution A；Wherein, the mass ratio of dry Folium clausenae lansii and ethanol is 1:8-15, and temperature is 18-30 DEG C, and extraction time is
0.5-1.2h, extracts 1 time；
(3) under microwave environment, with 5%HCl-ethanol as extracting solution, use dynamic technique of backflow to extract, divide after extraction
From, obtain Folium clausenae lansii residue and solution B；Wherein, the mass ratio of dry Folium clausenae lansii and 5%HCl-ethanol is 1:8-12, and temperature is 18-
30 DEG C, extraction time is 0.5-1.2h, extracts 1 time；；
(4) under microwave environment, with petroleum ether as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain
Folium clausenae lansii residue and solution C；Wherein, the mass ratio of dry Folium clausenae lansii and petroleum ether is 1:6-10, and temperature is 18-30 DEG C, during extraction
Between be 0.5-1.2h, extract 1 time；
(5) by solution A, solution B, solution C mix homogeneously, solution D is obtained；
(6) solution D employing is concentrated in vacuo, isolates extracting solution, obtain the Folium clausenae lansii extract of paste；
(7) Folium clausenae lansii extract of paste is dried, i.e. obtain the Folium clausenae lansii extract of powder, Folium clausenae lansii extract
Water content is less than 1%.
The extraction ratio influence factor of microwave auxiliary extraction technology includes: microwave frequency, the degree of grinding of material, solid-liquid ratio are (former
Material and the ratio of solvent), Extracting temperature, extraction be actual and extraction time, in embodiment 1, step (2), step (3) and step
(4) 1 time is all extracted, experimental result such as table 1:
Table 1
Embodiment 2
A kind of preparation method of Folium clausenae lansii extract, it comprises the following steps:
(1) Folium clausenae lansii is cleaned, oven drying at low temperature at 35-45 DEG C, dry Folium clausenae lansii is pulverized, cross 60-80 mesh sieve afterwards；
(2) under microwave environment, with ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Huang
Skin leaf residue and solution A；Wherein, the mass ratio of dry Folium clausenae lansii and ethanol is 1:8-15, and temperature is 18-30 DEG C, and extraction time is
0.5-1.2h, extracts 2 times；
(3) under microwave environment, with 5%HCl-ethanol as extracting solution, use dynamic technique of backflow to extract, divide after extraction
From, obtain Folium clausenae lansii residue and solution B；Wherein, the mass ratio of dry Folium clausenae lansii and 5%HCl-ethanol is 1:8-12, and temperature is 18-
30 DEG C, extraction time is 0.5-1.2h, extracts 2 times；；
(4) under microwave environment, with petroleum ether as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain
Folium clausenae lansii residue and solution C；Wherein, the mass ratio of dry Folium clausenae lansii and petroleum ether is 1:6-10, and temperature is 18-30 DEG C, during extraction
Between be 0.5-1.2h, extract 2 times；
(5) by solution A, solution B, solution C mix homogeneously, solution D is obtained；
(6) solution D employing is concentrated in vacuo, isolates extracting solution, obtain the Folium clausenae lansii extract of paste；
(7) Folium clausenae lansii extract of paste is dried, i.e. obtain the Folium clausenae lansii extract of powder, Folium clausenae lansii extract
Water content is less than 1%.
The extraction ratio influence factor of microwave auxiliary extraction technology includes: microwave frequency, the degree of grinding of material, solid-liquid ratio are (former
Material and the ratio of solvent), Extracting temperature, extraction be actual and extraction time, in embodiment 1, step (2), step (3) and step
(4) 2 times are all extracted, experimental result such as table 2:
Table 2
Embodiment 3
A kind of preparation method of Folium clausenae lansii extract, it comprises the following steps:
(1) Folium clausenae lansii is cleaned, oven drying at low temperature at 35-45 DEG C, dry Folium clausenae lansii is pulverized, cross 60-80 mesh sieve afterwards；
(2) under microwave environment, with ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Huang
Skin leaf residue and solution A；Wherein, the mass ratio of dry Folium clausenae lansii and ethanol is 1:8-15, and temperature is 18-30 DEG C, and extraction time is
0.5-1.2h, extracts 3 times；
(3) under microwave environment, with 5%HCl-ethanol as extracting solution, use dynamic technique of backflow to extract, divide after extraction
From, obtain Folium clausenae lansii residue and solution B；Wherein, the mass ratio of dry Folium clausenae lansii and 5%HCl-ethanol is 1:8-12, and temperature is 18-
30 DEG C, extraction time is 0.5-1.2h, extracts 2 times；；
(4) under microwave environment, with petroleum ether as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain
Folium clausenae lansii residue and solution C；Wherein, the mass ratio of dry Folium clausenae lansii and petroleum ether is 1:6-10, and temperature is 18-30 DEG C, during extraction
Between be 0.5-1.2h, extract 1 time；
(5) by solution A, solution B, solution C mix homogeneously, solution D is obtained；
(6) solution D employing is concentrated in vacuo, isolates extracting solution, obtain the Folium clausenae lansii extract of paste；
(7) Folium clausenae lansii extract of paste is dried, i.e. obtain the Folium clausenae lansii extract of powder, Folium clausenae lansii extract
Water content is less than 1%.
The extraction ratio influence factor of microwave auxiliary extraction technology includes: microwave frequency, the degree of grinding of material, solid-liquid ratio are (former
Material and the ratio of solvent), Extracting temperature, extraction be actual and extraction time, in embodiment 1, step (2) is extracted 3 times, step
(3) extracting 2 times, step (4) is extracted 1 time, experimental result such as table 3:
Table 3
Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, and this area is common
Other amendment or equivalents that technical scheme is made by technical staff, without departing from technical solution of the present invention
Spirit and scope, all should contain in the middle of scope of the presently claimed invention.
Claims (10)
1. a Folium clausenae lansii extract, it is characterised in that it is the active material admixture in Folium clausenae lansii, including alkaloid, many
Sugar, flavonoid glycoside, phenols, aminoacid, volatile oil, coumarin, terpenoid.
A kind of Folium clausenae lansii extract the most according to claim 1, it is characterised in that described Folium clausenae lansii is Yunan seedless wampee
Leaf.
3. the preparation method of a Folium clausenae lansii extract, it is characterised in that it comprises the following steps:
(1) Folium clausenae lansii is cleaned, oven drying at low temperature at 35-45 DEG C, dry Folium clausenae lansii is pulverized, cross 60-80 mesh sieve afterwards；
(2) under microwave environment, with ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Folium clausenae lansii
Residue and solution A；Wherein, the mass ratio of dry Folium clausenae lansii and ethanol is 1:8-15, and temperature is 18-30 DEG C, and extraction time is 0.5-
1.2h, extracts 1-3 time；
(3) under microwave environment, with 5%HCl-ethanol as extracting solution, use dynamic technique of backflow to extract, separate after extraction,
To Folium clausenae lansii residue and solution B；Wherein, the mass ratio of dry Folium clausenae lansii and 5%HCl-ethanol is 1:8-12, and temperature is 18-30 DEG C,
Extraction time is 0.5-1.2h, extracts 1-3 time；；
(4) under microwave environment, with petroleum ether as extracting solution, use dynamic technique of backflow to extract, separate after extraction, obtain Clausena lansium (Lour.) Skeels
Leaf residue and solution C；Wherein, the mass ratio of dry Folium clausenae lansii and petroleum ether is 1:6-10, and temperature is 18-30 DEG C, and extraction time is
0.5-1.2h, extracts 1-3 time；
(5) by solution A, solution B, solution C mix homogeneously, solution D is obtained；
(6) solution D employing is concentrated in vacuo, isolates extracting solution, obtain the Folium clausenae lansii extract of paste；
(7) Folium clausenae lansii extract of paste is dried, i.e. obtain the Folium clausenae lansii extract of powder, Folium clausenae lansii extract aqueous
Amount is for less than 1%.
The preparation method of a kind of Folium clausenae lansii extract the most according to claim 3, it is characterised in that step (2), step
(3) and step (4) use machine power to force solution backflow.
The preparation method of a kind of Folium clausenae lansii extract the most according to claim 3, it is characterised in that step (2), step
(3) and in step (4), isolation technics is for filtering.
The preparation method of a kind of Folium clausenae lansii extract the most according to claim 3, it is characterised in that step (2), step
(3) and in step (4), microwave frequency is 6000-10000 megahertz.
The preparation method of a kind of Folium clausenae lansii extract the most according to claim 3, it is characterised in that use in step (7)
Freeze Drying Technique.
8. the application of a Folium clausenae lansii extract, it is characterised in that described Folium clausenae lansii extract adds to as a kind of dispensing to be washed
Protect in articles for use.
The application of a kind of Folium clausenae lansii extract the most according to claim 8, it is characterised in that Folium clausenae lansii extract is applied
To hand cleaning class, anophelifuge class, class of taking a shower, prevent and treat in the washing product of miliaria class.
The application of a kind of Folium clausenae lansii extract the most according to claim 8 or claim 9, it is characterised in that a kind of Folium clausenae lansii that contains carries
Take the shower class cosmetic combinations of thing, by weight, including following components: live in Folium clausenae lansii extract 3-6 part, shower class surface
Property agent 3-12 part, anti-sensitizer 0.5-2 part, whitening agent 2.5-6 part, wetting agent 2-12 part, potassium hydroxide 0.03-0.2 part, thickening agent
0.1-0.3 part, emulsifying agent 1.5-5.8 part, preservative 0.2-1 part, deionized water 40-80 part.
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| CN106491503A (en) * | 2016-12-14 | 2017-03-15 | 黄文庆 | The extracting method of Folium clausenae lansii effective ingredient and its prepare the purposes of protective skin cream |
| WO2017155465A1 (en) * | 2016-03-11 | 2017-09-14 | Leeward Pacific Pte Ltd | Compound for use in the treatment and/or prevention of parasitic mediated diseases |
| CN108186372A (en) * | 2017-12-29 | 2018-06-22 | 青岛百瑞吉生物工程有限公司 | A kind of whitening and skin-protecting bathing effervescent tablet and preparation method thereof |
| CN111040451A (en) * | 2019-12-18 | 2020-04-21 | 佛山科学技术学院 | Mosquito-repelling and insect-preventing plastic product additive |
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