CN105900998A - Sterilization composition containing spiroxamine and famoxadone and application thereof - Google Patents

Sterilization composition containing spiroxamine and famoxadone and application thereof Download PDF

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Publication number
CN105900998A
CN105900998A CN201610342922.XA CN201610342922A CN105900998A CN 105900998 A CN105900998 A CN 105900998A CN 201610342922 A CN201610342922 A CN 201610342922A CN 105900998 A CN105900998 A CN 105900998A
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bacterium amine
volution bacterium
cycloheximide triazole
bactericidal composition
cycloheximide
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CN201610342922.XA
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Inventor
邢刚
陈叶青
杨琴
万维肖
程清云
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Nanjing Huazhou Pharmaceutical Co Ltd
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Nanjing Huazhou Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/761,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A01N43/28Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
    • A01N43/30Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a sterilization composition containing spiroxamine and famoxadone and application thereof. The sterilization composition takes spiroxamine and famoxadone as main effective components, wherein the mass ratio of spiroxamine to famoxadone is (1-90) to (1-90). The sterilization composition can be applied to prevention and treatment of diseases of cereals, fruit trees and vegetables, has relatively high synergistic effect, can be used for overcoming and delaying the drug resistance of bacteria, and has the advantages of rapid sterilization effect, long lasting period and capability of reducing the application cost; and the prevention and treatment effect is obviously better than that of a single dosage. The sterilization composition can be used for preventing and treating fungal diseases on the crops and is particularly suitable for preventing and treating the fungal diseases including powdery mildew, rust diseases, glume blight, net blotch, downy mildew, late blight and the like, and the effect is better than that of single dosages.

Description

A kind of containing volution bacterium amine and the bactericidal composition of cycloheximide triazole and application
Technical field:
The present invention relates to a kind of bactericidal composition and application thereof, especially one is main with volution bacterium amine and cycloheximide triazole The bactericidal composition of active component and application thereof.
Background technology
Volution bacterium amine (Spiroxamine), chemical formula: C18H35NO2, chemical name: the N-ethyl-N-propyl group-8-tert-butyl group- 1,4-dioxo spiro [4.5] decane-2-methylamine.Structural formula:
Volution bacterium amine is substitutional amine-group antibacterial, sterol biosynthesis inhibitor, main suppression pathogenic bacteria C-14 deoxidation methyl Change the synthesis of enzyme.Controlling object is wheat powdery mildew and various rust, barley leaf blotch and stripe disease.Volution bacterium amine is a kind of new Type, the foliage fungicide of interior absorption, have specially good effect to powdery mildew.Speed of action is fast and the lasting period is long, has protection and therapeutical effect concurrently.
Cycloheximide triazole (Famoxadone), molecular formula: C22H18N2O4, chemical name: 33-phenylamino-5-methyl-5-(4- Phenoxyphenyl)-1,3-oxazoline-2,4-diketone.Structural formula:
Cycloheximide triazole is new and effective, wide-spectrum bactericide. suitable for crop such as Semen Tritici aestivi, Fructus Hordei Vulgaris, Semen Pisi sativi, Radix Betae, Brassica campestris L, Portugal Grape, Rhizoma Solani tuber osi, pawl class, Fructus Capsici, Fructus Lycopersici esculenti etc..It is mainly used in the important disease preventing and treating in Ascomycetes, Basidiomycetes, oomycetes subclass Such as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight etc..
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, along with the change of pattern of farming, melon fruits and vegetables etc. Industrial crops cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in preventing and treating, difficulty strengthens;Separately On the one hand, the resistance of pathogen rises under lasting medicament selection pressure year by year, and the prevention effect of single dose is had a greatly reduced quality, plant Disease control is faced with significant challenge.
Summary of the invention:
It is an object of the invention to provide a kind of applied widely, low cost for above-mentioned technical problem, effective containing spiral shell Ring bacterium amine and the plant bactericidal composition of cycloheximide triazole.
It is a still further object of the present invention to provide this bactericidal composition and cause answering on fungal disease at preventing and treating plant epiphyte With, especially in the purposes prevented and treated on the fungal diseases such as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight.
It is an object of the invention to be achieved through the following technical solutions:
A kind of containing volution bacterium amine and the bactericidal composition of cycloheximide triazole, this bactericidal composition is with volution bacterium amine and cycloheximide triazole For principle active component, wherein volution bacterium amine is 1~90:1~90 with the mass ratio of cycloheximide triazole, wherein has in bactericidal composition Effective constituent is present in compositions with enhancing effective amount.
Described bactericidal composition, wherein the mass ratio of volution bacterium amine and cycloheximide triazole is preferably 1~70:1~50, described Bactericidal composition, wherein volution bacterium amine and the mass ratio more preferably 70:1 of cycloheximide triazole, 50:1,30:1,20:1, 10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30 or 1:50.
Described bactericidal composition, wherein volution bacterium amine is most preferably 1:1 with the mass ratio of cycloheximide triazole.
In the compositions of the present invention, account for both volution bacterium amine and cycloheximide triazole the weight/mass percentage composition of compositions be 2~ 80%.Preferably 10~40%.
Described bactericidal composition, wherein with volution bacterium amine and cycloheximide triazole for principle active component and known auxiliary agent and Excipient is re-dubbed on pesticide any one dosage form allowed.Known to these, auxiliary agent, excipient have dispersant, diffusant, disappear Infusion, wetting agent, disintegrating agent etc., can use calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, benzylphenol polyoxyethylene Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ring Oxidative ethane addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, NPE, tell Temperature series, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite, One or more combinations in lignosulfonates, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary etc., excipient includes Ketohexamethylene, dimethylbenzene, various solvent naphtha, water, antifreezing agent (such as propylene glycol), deionized water etc..Above auxiliary agent, excipient and other Adjuvant can be alone or and use.
Described bactericidal composition, its dosage form is cream, wettable powder, suspending agent, aqueous emulsion or water dispersion granule.
The application on preparation preventing and treating fungal diseases of plants medicine of the above-mentioned bactericidal composition.Especially preventing and treating cereal Application in terms of class, fruit tree, vegetable crop disease.
Above-mentioned application, described fungal diseases of plants is powdery mildew, rust, glume blight, net blotch, downy mildew, late blight At least one in disease.
Beneficial effects of the present invention:
1, the volution bacterium amine used by the present invention and cycloheximide triazole, the mechanism of action is different, and mutual mixture will not produce low touching, can Synergistic, reduces dosage, reduces cost.
2, the present composition scope of application increases, it is adaptable to preventing and treating Cereal, fruit tree, the refractory fungal disease of vegetable, Particularly prevent and treat powdery mildew, rust, glume blight, net blotch, downy mildew, late blight etc. and all have significant effect.The present invention sterilizes Compositions has good prevention effect to ascomycetes, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease;And suppress insect or true The bacterium drug-fast generation to unitary agent (volution bacterium amine and cycloheximide triazole are arbitrary).Bactericidal composition of the present invention can produce higher Synergistic function, and the consumption of the independent reactive compound of amount ratio of this mixture is substantially reduced, i.e. the work of mixture Property more than the activity of independent component.
Compared with prior art beneficial effects of the present invention: (1), compared with single dose, said composition antagonism fungal disease is such as The fungal diseases such as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight have obvious synergistic function, overcome and prolong Having delayed Drug resistance, expanding prevention is composed, hence it is evident that improve prevention effect;(2) preventing and treating recruitment, drug cost are reduced;(3) alternative often Advise and be easily generated the pesticide of resistance;(4) compared with single dose, produce and use cost reduces;(5) the suppression drug-fast product of fungus Raw, its effect uses apparently higher than its single dose.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of dosage form is routine side Method, " % " of the present invention is mass percent.
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure the different agents EC to bacterial strain50Value, uses co-toxicity coefficient calculating side Method, calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, and circular is as follows:
In mixture, a certain single dose (is generally selected EC as standard agent50Junior), calculate:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × A single dose toxicity index of proportion+B single dose in mixture of theoretical toxicity index=A single dose × B single dose proportion in mixture
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theory toxicity index × 100
When co-toxicity coefficient classification: CTC is more than 120, mixture has synergetic, is antagonism when CTC is less than 80, and CTC exists It it is summation action between 80-120.
According to effective ingredient volution bacterium amine (A): cycloheximide triazole (B) quality proportioning is: 70:1,50:1,30:1,20:1,10: 1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50 test, and measure it to Plasmopara viticola The co-toxicity coefficient of (Plasmopara viticola (Berk.dt Curtis) Berl.Et de Toni).
Table 1: the volution bacterium amine+cycloheximide triazole different ratio indoor biometrics result to Plasmopara viticola
Medicament Virulence regression equation EC50(mg/L) Co-toxicity coefficient
25% volution bacterium amine EC Y=4.769+1.253X 1.528 -
50% cycloheximide triazole WDG Y=4.038+2.360X 2.556 -
A:B=70:1 Y=4.638+1.266X 1.929 133.23
A:B=50:1 Y=4.675+1.687X 1.559 165.29
A:B=30:1 Y=4.581+2.302X 1.521 170.25
A:B=20:1 Y=4.382+2.654X 1.710 152.42
A:B=10:1 Y=4.284+2.897X 1.767 150.12
A:B=5:1 Y=4.401+1.847X 2.110 129.86
A:B=2.5:1 Y=4.453+1.663X 2.134 135.48
A:B=1:1 Y=4.652+1.546X 1.678 172.15
A:B=1:2 Y=4.741+0.798X 2.113 165.28
A:B=1:4 Y=4.349+1.542X 2.642 142.63
A:B=1:6 Y=4.202+1.632X 3.083 126.53
A:B=1:10 Y=4.252+1.585X 2.963 135.98
A:B=1:20 Y=4.097+2.030X 2.784 148.79
A:B=1:30 Y=3.271+4.210X 2.574 162.56
A:B=1:50 Y=4.323+1.558X 2.721 155.08
Field control effectiveness test:
The pesticidal preparations prepared by following embodiment prevents and treats downy mildew of garpe test.
1, test processes: this test medicine consumption sets three concentration for the treatment of respectively according to the difference of each composition, compares medicine Agent is pesticide single dose 25% volution bacterium amine EC and 50% cycloheximide triazole WDG and blank clean water experiment respectively.
2, each plot area of test method is 66.7m2, it is repeated 3 times;Investigation drug effect side after investigating before dispenser and preventing and treating Method is: randomization 5 point in test treatment region, carries out severity Scaling according to country's field test relevant criterion, calculates preventive effect. Result of the test is shown in Table 2:
Table 2 field test effect
Being shown by indoor biometrics and field efficacy result, volution bacterium amine and cycloheximide triazole compositions have the most collaborative Potentiation, the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, has application valency in agricultural is applied Value.
Two kinds of reactive compounds can be processed into any one dosage form of permission, illustrates two kinds with specific embodiment below The preparation that effective ingredient is processed into, but the preparation that these two kinds of active component can be processed is not limited only to set forth below.
Embodiment 1:15% volution bacterium amine cycloheximide triazole wettable powder (1:2)
By volution bacterium amine 5g, cycloheximide triazole 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, diffusion Agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, prepares effectively Ingredient percent is 15% volution bacterium amine cycloheximide triazole wettable powder.
Embodiment 2:15% volution bacterium amine cycloheximide triazole wettable powder (1:4)
By volution bacterium amine 3g, cycloheximide triazole 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite Soil adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is that 15% volution bacterium amine cycloheximide triazole can WP.
Embodiment 3:14% volution bacterium amine cycloheximide triazole wettable powder (1:6)
By volution bacterium amine 2g, cycloheximide triazole 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite Soil adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is that 14% volution bacterium amine cycloheximide triazole can WP.
Embodiment 4:20% volution bacterium amine cycloheximide triazole suspending agent (1:1)
Weigh 10g volution bacterium amine, 10g cycloheximide triazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, Xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, in the effect of sand mill Under to make effective Ingredient percent be 20% volution bacterium amine cycloheximide triazole suspending agent.
Embodiment 5:55% volution bacterium amine cycloheximide triazole aqueous emulsion (1:10)
Weigh 5g volution bacterium amine, 50g cycloheximide triazole, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl Phenol polyethenoxy ether 1g, solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into mixing Still high speed mixes, and making effective Ingredient percent is 55% volution bacterium amine cycloheximide triazole aqueous emulsion.Embodiment 6: 42% volution bacterium amine cycloheximide triazole cream (1:20)
Weigh 2g volution bacterium amine, 40g cycloheximide triazole, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, molten Agent is oily to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective composition quality hundred Proportion by subtraction is 42% volution bacterium amine cycloheximide triazole cream.
Embodiment 7:70% volution bacterium amine cycloheximide triazole cream (2.5:1)
Weigh 50g volution bacterium amine, 20g cycloheximide triazole, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, Castor oil polyoxyethylene ether 2g, solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts in mixing kettle mixed Closing, making effective Ingredient percent is 70% volution bacterium amine cycloheximide triazole cream.
Embodiment 8:18% volution bacterium amine cycloheximide triazole water dispersion granule (5:1)
Weigh 15g volution bacterium amine, 3g cycloheximide triazole, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, gather Vinyl alcohol 5g, Borax 2g, kieselguhr 28g complement to 100g, are formed with imitating composition by water dispersible granular agent method by above raw material Mass percent is 17% volution bacterium amine cycloheximide triazole water dispersion granule.
Embodiment 9:11% volution bacterium amine cycloheximide triazole cream (10:1)
Weigh 10g volution bacterium amine, 1g cycloheximide triazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, molten Agent is oily to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective composition quality hundred Proportion by subtraction is 11% volution bacterium amine cycloheximide triazole cream.
Embodiment 10:31.5% volution bacterium amine cycloheximide triazole microemulsion (20:1)
Weigh 30g volution bacterium amine, 1.5g cycloheximide triazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphorus Acid esters 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is prepared routinely The method of microemulsion puts in mixing kettle and mixes, and making effective Ingredient percent is that 32% volution bacterium amine cycloheximide triazole is micro- Emulsion.
Embodiment 11:31% volution bacterium amine cycloheximide triazole cream (30:1)
Weigh 30g volution bacterium amine, 1g cycloheximide triazole, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, molten Agent is oily to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective composition quality hundred Proportion by subtraction is 31% volution bacterium amine cycloheximide triazole cream.
Embodiment 12:51% volution bacterium amine cycloheximide triazole suspending agent (50:1)
Weigh 50g volution bacterium amine, 1g cycloheximide triazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, Huang Virgin rubber 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill Making effective Ingredient percent is 51% volution bacterium amine cycloheximide triazole suspending agent.
Embodiment 13:32% volution bacterium amine cycloheximide triazole microemulsion (1:15)
Weigh 2g volution bacterium amine, 30g cycloheximide triazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphoric acid Ester 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is prepared micro-routinely The method of Emulsion puts in mixing kettle and mixes, and making effective Ingredient percent is 32% volution bacterium amine cycloheximide triazole microemulsion Agent.
Embodiment 14:6% volution bacterium amine cycloheximide triazole aqueous emulsion (1:5)
Weigh 1g volution bacterium amine, 5g cycloheximide triazole, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol Polyoxyethylene ether 1g, solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into mixing kettle High speed mixes, and making effective Ingredient percent is 6% volution bacterium amine cycloheximide triazole aqueous emulsion.
Embodiment 15:62% volution bacterium amine cycloheximide triazole microemulsion (1:30)
Weigh 2g volution bacterium amine, 60g cycloheximide triazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphoric acid Ester 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is prepared micro-routinely The method of Emulsion puts in mixing kettle and mixes, and making effective Ingredient percent is 62% volution bacterium amine cycloheximide triazole microemulsion Agent.
Embodiment 16:51% volution bacterium amine cycloheximide triazole suspending agent (1:50)
Weigh 1g volution bacterium amine, 50g cycloheximide triazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, Huang Virgin rubber 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill Making effective Ingredient percent is 51% volution bacterium amine cycloheximide triazole suspending agent.
Embodiment 17:7% volution bacterium amine cycloheximide triazole water dispersion granule (1:2.5)
Weigh 2g volution bacterium amine, 5g cycloheximide triazole, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, poly-second Enol 5g, Borax 2g, white carbon 3g, kieselguhr complement to 100g, by water dispersible granular agent method, above raw material are formed with effect Ingredient percent is 7% volution bacterium amine cycloheximide triazole water dispersion granule.

Claims (9)

1. one kind contains volution bacterium amine and the bactericidal composition of cycloheximide triazole, it is characterised in that this bactericidal composition with volution bacterium amine and Cycloheximide triazole is principle active component, and wherein volution bacterium amine is 1~90:1~90 with the mass ratio of cycloheximide triazole.
Bactericidal composition the most according to claim 1, it is characterised in that described volution bacterium amine and the mass ratio of cycloheximide triazole It is 1~70:1~50.
Bactericidal composition the most according to claim 1, it is characterised in that described volution bacterium amine and the mass ratio of cycloheximide triazole For 1:1.
Bactericidal composition the most according to claim 1, it is characterised in that both described volution bacterium amine and cycloheximide triazole account for The weight/mass percentage composition of compositions is 2-80%.
Bactericidal composition the most according to claim 4, it is characterised in that both described volution bacterium amine and cycloheximide triazole account for The weight/mass percentage composition of compositions is 10-40%.
Bactericidal composition the most according to claim 1, it is characterised in that with volution bacterium amine and cycloheximide triazole for main effectively Composition and insecticides adjuvant are configured on pesticide any one dosage form allowed.
Bactericidal composition the most according to claim 6, it is characterised in that described dosage form be cream, suspending agent, aqueous emulsion, Wettable powder or water dispersion granule.
8. the application on preparation preventing and treating fungal diseases of plants medicine of the bactericidal composition described in claim 1.
Application the most according to claim 8, it is characterised in that described fungal diseases of plants be powdery mildew, rust, grain husk withered At least one in disease, net blotch, downy mildew, late blight.
CN201610342922.XA 2016-05-20 2016-05-20 Sterilization composition containing spiroxamine and famoxadone and application thereof Pending CN105900998A (en)

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CN101822251A (en) * 2010-01-27 2010-09-08 深圳诺普信农化股份有限公司 Sterilization compound containing ZJ0712
CN104054708A (en) * 2014-05-31 2014-09-24 海利尔药业集团股份有限公司 Bactericidal composition containing meptyldinocap and spiroxamine

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851405A (en) * 1987-03-07 1989-07-25 Bayer Aktiengesellschaft Aminomethyl heterocyclic compounds
US20030065001A1 (en) * 1997-12-01 2003-04-03 Harald Walter Fungicidal combinations comprising quinazolinone
CN101779675A (en) * 2009-12-16 2010-07-21 陈章艳 Sterilization composition containing difenoconazole
CN101731230A (en) * 2009-12-30 2010-06-16 深圳诺普信农化股份有限公司 Famoxadone-containing sterilizing composition
CN101822251A (en) * 2010-01-27 2010-09-08 深圳诺普信农化股份有限公司 Sterilization compound containing ZJ0712
CN104054708A (en) * 2014-05-31 2014-09-24 海利尔药业集团股份有限公司 Bactericidal composition containing meptyldinocap and spiroxamine

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Application publication date: 20160831