CN105878367A - Herba salviae plebeiae extract effervescent tablets and preparation method thereof - Google Patents
Herba salviae plebeiae extract effervescent tablets and preparation method thereof Download PDFInfo
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- CN105878367A CN105878367A CN201610288011.3A CN201610288011A CN105878367A CN 105878367 A CN105878367 A CN 105878367A CN 201610288011 A CN201610288011 A CN 201610288011A CN 105878367 A CN105878367 A CN 105878367A
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- Prior art keywords
- effervescent tablet
- parts
- acid
- extract effervescent
- salvia plebeia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Abstract
The invention discloses herba salviae plebeiae extract effervescent tablets and a preparation method thereof. The herba salviae plebeiae extract effervescent tablets are prepared from the following components in parts by weight: 12 parts of herba salviae plebeiae powder, 16 parts of a carbon dioxide source, 32 parts of an acid source, 3 parts of a sweetening agent, 10 parts of a binding agent, 3 parts of a lubricating agent, 23.5 parts of a filler and 0.5 part of arabian jasmine flower powder flavor. The herba salviae plebeiae extract effervescent tablets are simple and convenient in technical operation, low in sticking possibility and smooth in slice discharge and have certain practicability.
Description
Technical field:
The present invention relates to the making of effervescent tablet, particularly a kind of salvia plebeia extract effervescent tablet and preparation method thereof.
Background technology:
Herba Salviae Plebeiae is the herb that Lamiaceae Salvia platymiscium snow is shown in grass, has another name called toad grass, leprosy belly grass, leprosy belly etc., for biennial upright herbaceous plant, high 15～90cm, multi-branched, stem is square, there are pubescence, leaf Long Circle or lanceolar, length 2～6cm, wide 0.8～2.5cm, tip is blunt or anxious sharp, basal circular or wedge shape, and there is crenature at edge, there is golden yellow gland point below, arteries and veins has pubescence.In addition to Qinghai, Tibet, Xinjiang, Gansu, almost it is distributed in all parts of the country.Beginning to be loaded in Compendium of Material Medica as Chinese medicine, once record in the Pharmacopoeia of the People's Republic of China (version in 1977), property is put down, and acrid in the mouth is nontoxic.Modern pharmacology research shows: Herba Salviae Plebeiae have cough-relieving, relieving asthma, antibacterial, antiviral, antitumor, hemostasis, the multiple effect such as antiinflammatory and antioxidation.The existing wild distribution of Herba Salviae Plebeiae, has again artificial culture, and resource is sufficient, cheap, has potential development and application values.
Effervescent tablet belongs to a kind of special form in tablet, and water met by effervescent tablet, and bronsted lowry acids and bases bronsted lowry therein can occur chemical reaction and discharge substantial amounts of carbon dioxide and make effervescent tablet effervescent disintegrate.Owing to being swift in response, being easy to carry, the advantage such as taking convenience, composition be relatively stable, increasingly paid close attention to by everybody.Originally for pharmaceutical field, in recent years, gradually expand to food service industry.
Summary of the invention:
It is an object of the invention to provide salvia plebeia extract effervescent tablet that a kind of processing method is convenient, using effect is good and preparation method thereof.
The technical scheme is that, a kind of salvia plebeia extract effervescent tablet, it is characterised in that: the composition of salvia plebeia extract effervescent tablet includes: the Fructus Litchi grass meal of 12 weight portions；The carbon dioxide source of 16 weight portions；And the acid source that weight portion is carbon dioxide source 2 times；The sweeting agent of 3 parts；The binding agent of 10 parts；The lubricant of 3 parts；Filler 23.5 weight portion；Flos Jasmini Sambac powdered flavor 0.5 part.
Described carbon dioxide source: for the one in sodium bicarbonate, sodium carbonate potassium carbonate.
Described acid source: for the one in citric acid, citric acid, tartaric acid.
Described sweeting agent: for the one in lactose xylitol steviol glycosides.
Described binding agent: for the one in polyvinylpyrrolidone (PVP, k-30) ethanol solution (volumes of aqueous ethanol mark is 70%), hydroxypropyl methyl cellulose (HPMC), maltodextrin, concentration is 20%-30%.
Described lubricant: for the one in magnesium stearate micropowder silica gel polyethylene glycol 6000 (PEG6000).
Described filler is mannitol.
Being prepared as of Fructus Litchi grass meal: by dry Herba Salviae Plebeiae herb deionized water rinsing 3 times, it is placed in oven for drying under the conditions of 50 DEG C, then powder is beaten with cooking machine, add, in the ratio of 1:5 (g/mL), the ethanol solution that certain volume volume fraction is 95% and (this technique claims Herba Salviae Plebeiae plant powder 100g, add deionized water 500ml), use low-frequency ultrasonic waves (250W, 20 kHz), stirring and leaching 60min under the conditions of 50 DEG C, filter with 60 mesh filter screens, filter vacuum concentrates, by concentrated solution centrifugation (traditional vacuum concentrating instrument, parameter is arranged: room temperature, speed 1000 revs/min), take the freeze-dried salvia plebeia extract lyophilized powder of i.e. making of supernatant and (use freezer dryer operation, freezer dryer parameter: condensation temperature :-50 DEG C；Vacuum: < 20Pa；Lyophilizing area: 0.12).Obtained salvia plebeia extract powder is fine and smooth, and color is breen, has the distinctive delicate fragrance of Herba Salviae Plebeiae.
The preparation method of a kind of salvia plebeia extract effervescent tablet is, it is characterized in that: after above-mentioned various components are extracted according to weight portion, first Fructus Litchi grass meal, acid source, sweeting agent, binding agent are crossed 80 mesh sieves, then added dehydrated alcohol (volumes of aqueous ethanol mark is 70%), rub soft material processed；Pelletize after 18 mesh sieves, through the drying of 53 DEG C, after 60min, crossing 16 mesh sieve granulate, obtaining acid grain through 53 DEG C of drying；Fructus Litchi grass meal, alkali source cross 80 mesh sieves, add lubricant and obtain alkali grain；The alkali grain prepared is added after acid grain carries out tabletting again and can be prepared by Herba Salviae Plebeiae effervescent tablet after 53 DEG C dry 60min.
According to formula, the effervescent tablet of system being carried out quality testing, index is respectively hardness gas production disintegration time friability and pH value.Through analyzing, the average tablet quality of obtained Herba Salviae Plebeiae effervescent tablet is 2.5g, is diametrically the circular tablet of 1cm any surface finish, pH4.02, gas production 85mL, disintegration time 3.9min；Average hardness is 66N, friability 0.71%.
Present invention process is simple to operation, is difficult to sticking, energy slice smoothly, has certain practicality.The Herba Salviae Plebeiae effervescent tablet prepared by this kind of method, effervescent effect is preferable, put in warm water can complete disintegrate in 5min, the solution after dissolving is yellow green, good mouthfeel, it is easy to for various people's acceptance, have the preferable prospect of marketing.
Detailed description of the invention:
Embodiment 1,
A kind of salvia plebeia extract effervescent tablet, the composition of Herba Salviae Plebeiae effervescent tablet includes: gross weight is the Fructus Litchi grass meal of 5 weight portions；The sodium bicarbonate of 6.7 weight portions；And the citric acid that weight portion is sodium bicarbonate 2 times；The lactose of 1.25 weight portions；Polyvinylpyrrolidone (PVP, the k-30) ethanol solution (volumes of aqueous ethanol mark is 70%) of 4.2 weight portions；The magnesium stearate of 1.25 weight portions；The mannitol of 9.8 weight portions；The Flos Jasmini Sambac powdered flavor of 0.2 weight portion.
After above-mentioned various components are extracted according to weight portion, first Fructus Litchi grass meal, acid source, sweeting agent, binding agent are crossed 80 mesh sieves, then added dehydrated alcohol (99.7%), rub soft material processed；Pelletize after 18 mesh sieves, through the drying of 53 DEG C, after 60min, crossing 16 mesh sieve granulate, obtaining acid grain through 53 DEG C of drying；Fructus Litchi grass meal, alkali source cross 80 mesh sieves, add lubricant and obtain alkali grain；The alkali grain prepared is added after acid grain carries out tabletting again and can be prepared by Herba Salviae Plebeiae effervescent tablet after 53 DEG C dry 60min.
Embodiment 2,
A kind of salvia plebeia extract effervescent tablet, the composition of Herba Salviae Plebeiae effervescent tablet includes: gross weight is the Fructus Litchi grass meal of 10 weight portions；The potassium carbonate of 13.3 weight portions；And the citric acid that weight is sodium carbonate 2 times；The xylitol of 2.5 weight portions；The hydroxypropyl methyl cellulose of 8.3 weight portions；The micropowder silica gel of 2.5 weight portions；The mannitol of 19.6 weight portions；The Flos Jasmini Sambac powdered flavor of 0.6 weight portion.
After above-mentioned various components are extracted according to weight portion, first Fructus Litchi grass meal, acid source, sweeting agent, binding agent are crossed 80 mesh sieves, then added dehydrated alcohol (99.7%), rub soft material processed；Pelletize after 18 mesh sieves, through the drying of 53 DEG C, after 60min, crossing 16 mesh sieve granulate, obtaining acid grain through 53 DEG C of drying；Fructus Litchi grass meal, alkali source cross 80 mesh sieves, add lubricant and obtain alkali grain；The alkali grain prepared is added after acid grain carries out tabletting again and can be prepared by Herba Salviae Plebeiae effervescent tablet after 53 DEG C dry 60min.
Embodiment 3,
A kind of salvia plebeia extract effervescent tablet, the composition of Herba Salviae Plebeiae effervescent tablet includes: gross weight is the Fructus Litchi grass meal of 20 weight portions；The sodium carbonate of 25.6 weight portions；And the tartaric acid that weight portion is sodium carbonate 2 times；The steviol glycosides of 4.8 weight portions；The maltodextrin of 16 weight portions；The polyethylene glycol 6000 of 4.8 weight portions；The mannitol of 37.6 weight portions；The Flos Jasmini Sambac powdered flavor of 0.8 weight portion.
After above-mentioned various components are extracted according to weight portion, first Fructus Litchi grass meal, acid source, sweeting agent, binding agent are crossed 80 mesh sieves, then added dehydrated alcohol (99.7%), rub soft material processed；Pelletize after 18 mesh sieves, through the drying of 53 DEG C, after 60min, crossing 16 mesh sieve granulate, obtaining acid grain through 53 DEG C of drying；Fructus Litchi grass meal, alkali source cross 80 mesh sieves, add lubricant and obtain alkali grain；The alkali grain prepared is added after acid grain carries out tabletting again and can be prepared by Herba Salviae Plebeiae effervescent tablet after 53 DEG C dry 60min.
This technological operation is simple and convenient, is difficult to sticking, energy slice smoothly, has certain practicality.The Herba Salviae Plebeiae effervescent tablet prepared by this kind of method, effervescent effect is preferable, put in warm water can complete disintegrate in 5min, the solution after dissolving is yellow green, good mouthfeel, it is easy to for various people's acceptance, have the preferable prospect of marketing.
Above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also cannot all of embodiment be given exhaustive, and within the obvious change thus extended out or variation are still in the protection domain of the invention.
Claims (8)
1. a salvia plebeia extract effervescent tablet, it is characterised in that: the composition of salvia plebeia extract effervescent tablet includes: the Fructus Litchi grass meal of 12 weight portions；The carbon dioxide source of 16 weight portions；And the acid source that weight portion is carbon dioxide source 2 times；The sweeting agent of 3 parts；The binding agent of 10 parts；The lubricant of 3 parts；Filler 23.5 weight portion；Flos Jasmini Sambac powdered flavor 0.5 part.
2. a kind of salvia plebeia extract effervescent tablet as claimed in claim 1, it is characterised in that: described carbon dioxide source: for the one in sodium bicarbonate, sodium carbonate, potassium carbonate.
3. a kind of salvia plebeia extract effervescent tablet as claimed in claim 1, it is characterised in that: described acid source: for the one in citric acid, citric acid, tartaric acid.
4. a kind of salvia plebeia extract effervescent tablet as claimed in claim 1, it is characterised in that: described sweeting agent: for the one in lactose xylitol steviol glycosides.
5. a kind of salvia plebeia extract effervescent tablet as claimed in claim 1, it is characterised in that: described binding agent: for the one in polyvinylpyrrolidone ethanol solution, hydroxypropyl methyl cellulose, maltodextrin, concentration is 20%-30%.
6. a kind of salvia plebeia extract effervescent tablet as claimed in claim 1, it is characterised in that: described lubricant: for the one in magnesium stearate micropowder silica gel polyethylene glycol 6000.
7. a kind of salvia plebeia extract effervescent tablet as claimed in claim 1, it is characterised in that: described filler is mannitol.
8. the preparation method of a salvia plebeia extract effervescent tablet is, it is characterised in that: after above-mentioned various components are extracted according to weight portion, first Fructus Litchi grass meal, acid source, sweeting agent, binding agent are crossed 80 mesh sieves, then added dehydrated alcohol, rub soft material processed；Pelletize after 18 mesh sieves, through the drying of 53 DEG C, after 60min, crossing 16 mesh sieve granulate, obtaining acid grain through 53 DEG C of drying；Fructus Litchi grass meal, alkali source cross 80 mesh sieves, add lubricant and obtain alkali grain；The alkali grain prepared is added after acid grain carries out tabletting again and can be prepared by Herba Salviae Plebeiae effervescent tablet after 53 DEG C dry 60min.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610288011.3A CN105878367A (en) | 2016-05-04 | 2016-05-04 | Herba salviae plebeiae extract effervescent tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610288011.3A CN105878367A (en) | 2016-05-04 | 2016-05-04 | Herba salviae plebeiae extract effervescent tablets and preparation method thereof |
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| CN105878367A true CN105878367A (en) | 2016-08-24 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108567093A (en) * | 2018-04-20 | 2018-09-25 | 怀化学院 | A kind of Pasania cuspidata extract effervescent tablet and preparation method thereof |
| CN109907200A (en) * | 2019-03-14 | 2019-06-21 | 上海市农业科学院 | A kind of cordyceps sinensis effervescing piece and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138554A (en) * | 2006-09-05 | 2008-03-12 | 云南白药集团股份有限公司 | Effervescence dispersible tablet |
| CN103610733A (en) * | 2013-10-28 | 2014-03-05 | 曹德明 | Application of Medicagohispida Gaertn in preparation of hypolipemic and hpyerglycemic healthcare products |
-
2016
- 2016-05-04 CN CN201610288011.3A patent/CN105878367A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138554A (en) * | 2006-09-05 | 2008-03-12 | 云南白药集团股份有限公司 | Effervescence dispersible tablet |
| CN103610733A (en) * | 2013-10-28 | 2014-03-05 | 曹德明 | Application of Medicagohispida Gaertn in preparation of hypolipemic and hpyerglycemic healthcare products |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108567093A (en) * | 2018-04-20 | 2018-09-25 | 怀化学院 | A kind of Pasania cuspidata extract effervescent tablet and preparation method thereof |
| CN109907200A (en) * | 2019-03-14 | 2019-06-21 | 上海市农业科学院 | A kind of cordyceps sinensis effervescing piece and preparation method thereof |
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Application publication date: 20160824 |