CN103610733A - Application of Medicagohispida Gaertn in preparation of hypolipemic and hpyerglycemic healthcare products - Google Patents

Application of Medicagohispida Gaertn in preparation of hypolipemic and hpyerglycemic healthcare products Download PDF

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CN103610733A
CN103610733A CN201310517114.9A CN201310517114A CN103610733A CN 103610733 A CN103610733 A CN 103610733A CN 201310517114 A CN201310517114 A CN 201310517114A CN 103610733 A CN103610733 A CN 103610733A
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seedling grass
dry
application according
grass
coarse grain
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曹德明
曹阳
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Abstract

The invention discloses an application of Medicagohispida Gaertn in the preparation of hypolipemic and hpyerglycemic healthcare products. The dosage forms of the healthcare products comprise a tablet, an effervescent tablet, a capsule and an oral liquid. The invention also discloses preparation methods of all the dosage forms. Compared with products prepared through the prior art, the Medicagohispida Gaertn healthcare products obtained in the invention have a reasonable and simple technology, and have good curative effects on the hypolipemic and hyperglycemic.

Description

The application of seedling grass in preparation blood fat reducing, health-caring product capable of reducing blood sugar
Technical field
The present invention relates to a kind of processing of farm products method, be specifically related to a kind of processing method of seedling grass, be applied to agriculture field.
Background technology
Seedling grass, formal name used at school medicago hispida, has another name called Herba Loti Tenuis, three leaf vegetables, toothed burclover etc., belongs to annual herb plant.Because tolerance to cold, drought resistance, the diseases and insect pests resistance of seedling grass are strong, so whole growth course preventing disease pest control not is substantially pollution-free green food truly.It contains multivitamin, aminoacid, dietary fiber, useful inorganic salt and compared with multiple trace element, contain the abundantest vitamin K, the height becoming minute, almost one cut vegetables on, other is as also quite abundant in protein, Vitamin A, C, B content, is the vegetable that nutritive value is higher.The plantation at China's Jiangsu-zhejiang Shanghai Area one band with 2000 is historical, and the 60-70 age is used as green manure, and people are also as vegetable edible use sometimes, and custom is " crossing life grass ".For these years, the nutritive value of seedling grass, edibility are all fully used.Along with eating gradually of people, the development of agricultural economy and scientific and technical raising, seedling grass appropriate scale of operation degree progressively improves, and the utilization of seedling grass is edible to people from green manure to feed advance.
The feature of seedling grass nutritive value is to enrich comprehensively, and protein, vitamin content enrich, and the content that is rich in dietary cellulose, vitamin B12 and vitamin K is high, and the content of carotene surpasses Radix Dauci Sativae; Hyperkalemia hyponatremia, ferrum, Se content are also very abundant.Through modern trophic analysis, prove, seedling grass has inhibitory action to tumor, again can blood fat reducing, anticoagulation, anti-hemorrhage, clear interior-heat.Plant Saponin that it contains can and human body in cholesterol combination, can promote excretion, thereby greatly reduce cholesterol level, protect arterial wall, to the subcutaneous ulcer of harnessing the Yellow River, lithangiuria, prevent and treat coronary heart disease powerful.Having the effect of fat-reducing, black hair, is also diabetes, cardiac's good vegetables.At present, not seedling grass health product listing on market, the treatment process of seedling grass is critical process prepared by seedling grass health product, is being related to the quality of seedling grass health product finished product.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides seedling grass in preparation blood fat reducing or/and the application in health-caring product capable of reducing blood sugar, and provide described health product and preparation method thereof.
Technical scheme: for achieving the above object, the invention provides seedling grass and preparing blood fat reducing or/and the application in health-caring product capable of reducing blood sugar.
Preferably, described health product are tablet, effervescent tablet, capsule or oral liquid.
More preferably, described tablet is mainly made by the component of following weight portion: 100 parts of seedling grass, diluent 50-100 part, adhesive 2-10 part, disintegrating agent 0.5-5 part, lubricant 0.1-0.5 part.
The preparation method of above-mentioned tablet, it is mainly to be made by following steps:
(1) seedling grass is cleaned, dewaters, is dried, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with diluent and disintegrating agent, sieve, obtain mixture;
(3) adhesive is dissolved with ethanol water, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is sieved granulation, dry, granulate;
(5) add lubricant, mix homogeneously, tabletting, obtains.
Further preferably, in above-mentioned preparation method, the baking temperature of described step (1) is 40-70 ℃, and be 20-40 minute drying time; In described step (2), sieve as crossing 80-100 mesh sieve; In described step (3), in ethanol water, the percent by volume of ethanol is 40-70%; In described step (4), sieve as crossing 20-30 mesh sieve.
More preferably, described effervescent tablet is mainly made by the component of following weight portion: 100 parts of seedling grass, diluent 50-100 part, adhesive 2-10 part, sodium bicarbonate 0.1-0.5 part, citric acid 0.1-0.5 part, lubricant 0.05-0.1 part.
The preparation method of above-mentioned effervescent tablet, it is mainly to be made by following steps:
(1) seedling grass is cleaned, dewaters, is dried, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with the sodium bicarbonate of diluent, 40-60% amount and the citric acid of 40-60% amount, sieve, obtain mixture;
(3) adhesive is dissolved with ethanol water, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is sieved granulation, dry, granulate;
(5) add sodium bicarbonate and the citric acid of lubricant, surplus, mix homogeneously, tabletting, obtains.
Further preferably, in above-mentioned preparation method, the baking temperature of described step (1) is 40-70 ℃, and be 20-40 minute drying time; In described step (2), sieve as crossing 80-100 mesh sieve; In described step (3), in ethanol water, the percent by volume of ethanol is 40-70%; In described step (4), sieve as crossing 20-30 mesh sieve.
More preferably, described capsule is mainly made by the component of following weight portion: 100 parts of seedling grass, diluent 50-100 part, adhesive 2-10 part, disintegrating agent 0.5-5 part.
The preparation method of above-mentioned capsule, it is mainly to be made by following steps:
(1) seedling grass is cleaned, dewaters, is dried, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with diluent and disintegrating agent, sieve, obtain mixture;
(3) adhesive is dissolved with ethanol water, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is sieved granulation, dry, granulate, encapsulated, obtain.
Further preferably, in above-mentioned preparation method, the baking temperature of described step (1) is 40-70 ℃, and be 20-40 minute drying time; In described step (2), sieve as crossing 80-100 mesh sieve; In described step (3), in ethanol water, the percent by volume of ethanol is 40-70%; In described step (4), sieve as crossing 20-30 mesh sieve.
Further preferably, in above-mentioned ownership Preparation Method, described diluent is selected from one or more in starch, sucrose, dextrin and lactose; Described adhesive is selected from a kind of in starch, hypromellose, sodium carboxymethyl cellulose, polyvidone and Polyethylene Glycol; Described disintegrating agent is selected from a kind of in microcrystalline Cellulose, sodium alginate, carboxymethyl starch sodium and low-substituted hydroxypropyl cellulose; Described lubricant is selected from a kind of in Pulvis Talci, magnesium stearate.
More preferably, described oral liquid is mainly made by the component of following weight portion: 100 parts of seedling grass, sweeting agent 0.01-0.05 part, antiseptic 0.01-0.05 part, antioxidant 0.01-0.05 part.
Above-mentioned oral liquid is mainly to be made by following steps:
(1) seedling grass is added to pure water heating extraction, extracting solution is condensed into fluid extract;
(2) fluid extract thin up, adds sweeting agent, antiseptic and antioxidant, stirs, and being diluted to relative density is that 1.04-1.08(compares with the density of pure water);
(3) fill, sterilizing, obtains.
Further preferably, described sweeting agent is selected from a kind of in aspartame, stevioside; Described antiseptic is selected from a kind of in ethyl hydroxybenzoate, benzoic acid, sorbic acid; Described antioxidant is selected from a kind of in sodium sulfite, sodium pyrosulfite, sodium thiosulfate.
Beneficial effect: the present invention is with respect to prior art, gained seedling grass health product, the treatment process of seedling grass is rationally simple, for blood fat reducing, blood sugar lowering aspect, has good curative effect.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1:
Prescription: 100 parts of seedling grass, 80 parts of starch, 8 parts of hypromelloses, 2 parts of microcrystalline Cellulose, 0.3 part of Pulvis Talci
Preparation method: (1) seedling taking grass, clean, dry 40 minutes of dehydration, 40 ℃, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with starch and microcrystalline Cellulose, cross 80 mesh sieves, obtain mixture;
(3) ethanol water for hypromellose (percent by volume of ethanol is 40%) is dissolved, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is crossed to 20 mesh sieves and granulated, dry, granulate;
(5) add Pulvis Talci, mix homogeneously, tabletting, obtains.
Embodiment 2:
Prescription: 100 parts of seedling grass, 80 parts of sucrose, 6 parts of starch, 0.3 part of sodium bicarbonate, 0.3 part of citric acid, 0.08 part of magnesium stearate;
(1) seedling taking grass, cleans, dry 20 minutes of dehydration, 70 ℃, obtains dry seedling grass;
(2) above-mentioned dry seedling grass meal is broken, mix homogeneously with the sodium bicarbonate of sucrose, 50% amount and the citric acid of 50% amount, cross 100 mesh sieves, obtain mixture;
(3) ethanol water for starch (percent by volume of ethanol is 70%) is dissolved, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is crossed to 30 mesh sieves and granulated, dry, granulate;
(5) add sodium bicarbonate and the citric acid of magnesium stearate, surplus, mix homogeneously, tabletting, obtains.
Embodiment 3:
Prescription: 100 parts of seedling grass, 80 parts, dextrin, 6 parts of sodium carboxymethyl cellulose, 3 parts of carboxymethyl starch sodium;
Preparation method: (1) seedling taking grass, clean, dry 30 minutes of dehydration, 55 ℃, obtain dry seedling grass;
(2) above-mentioned dry seedling grass meal is broken, mix homogeneously with dextrin and carboxymethyl starch sodium, cross 90 mesh sieves, obtain mixture;
(3) ethanol water for sodium carboxymethyl cellulose (percent by volume of ethanol is 55%) is dissolved, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is crossed to 25 mesh sieves and granulated, dry, granulate, encapsulated, obtain.
Embodiment 4:
Prescription: 100 parts of seedling grass, 0.03 part of stevioside, 0.03 part of sorbic acid, 0.03 part of sodium sulfite
Preparation method: (1) seedling taking grass, add 8 times of pure water of measuring volumes of seedling grass weight, heating extraction 3 times, merge extractive liquid,, is condensed into fluid extract;
(2) fluid extract thin up, adds stevioside, stevioside and sodium sulfite, stirs, and being diluted to relative density is that 1.06(compares with pure water density);
(3) fill, 121 ℃ of sterilizings 15 minutes, obtain.
Embodiment 5:
Prescription: 100 parts of seedling grass, 80 parts of lactose, 8 parts of polyvidones, 2 parts of sodium alginates, 0.3 part of Pulvis Talci
Preparation method: (1) seedling taking grass, clean, dry 30 minutes of dehydration, 60 ℃, obtain dry seedling grass;
(2) above-mentioned dry seedling grass meal is broken, mix homogeneously with lactose and sodium alginate, cross 80 mesh sieves, obtain mixture;
(3) ethanol water for polyvidone (percent by volume of ethanol is 45%) is dissolved, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is crossed to 30 mesh sieves and granulated, dry, granulate;
(5) add Pulvis Talci, mix homogeneously, tabletting, obtains.
Experimental example
One, gained seedling grass health product lipid-lowering test example of the present invention
1 data and method
1.1 experiment material
1.1.1 the health product embodiment of the present invention 1 of the present invention, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 gained health product.
1.1.2 medicine and reagent cholesterol, specification 25g, by Beijing, extensive and profound in meaning star biotechnology responsibility company limited produces; Propylthiouracil ,You Shanghai Fosun Zhaohui Pharmaceutical Co., Ltd. produces; Lipid determination test kit, is provided by Japan first chemical Zhu Shi society.
1.1.3 laboratory animal SD rat is 105, and by Shanghai, western pul-Kai laboratory animal company limited provides, male and female dual-purpose, body weight 150g~250g.
1.1.4 high lipid food is comprised of 1% cholesterol, 10% leaf fat, 0.2% propylthiouracil and 88.8% normal feedstuff.
1.1.5 instrument lipid determination adopts the full-automatic analyser of the 7600-02 of Hitachi type, by Japanese the first KCC, is provided.
1.2 clinical indexes
Serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C), unit is mmol/L.
1.3 experimental technique
1.3.1 modeling
High blood lipid model rat high lipid food is fed, and fasting 12h after 6 weeks randomly draws 2 rat extracting bloods and surveys lipids contents to confirm modeling success.
1.3.2 grouping and administration
Get 105 of rats, be divided at random 7 groups, every group 15, be respectively normal group, model group, embodiment 1 intervention group, embodiment 2 intervention group, embodiment 3 intervention group, embodiment 4 intervention group, embodiment 5 intervention group, normal group is to normal rats gavaged distilled water 42mL/kg, and model group is on modeling rat basis, to gavage distilled water 42mL/kg, latter 5 groups to gavage respectively the embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 health product 42mg/kg.Above-mentioned intervention group is all on modeling rat basis, to give gained health product of the present invention.All animals administration every day 1 time, successive administration is put to death animal after 3 weeks, and separation of serum is measured the content of serum total cholesterol (TC), triglyceride (TG) and highdensity lipoprotein-cholesterol (HDL-C).
1.4 date processing
Adopt SPSS16.0 statistical software to process.Testing each index determining result represents with Mean scholar SD.Between group, mean relatively adopts one factor analysis of variance and paired t-test, and P<0.05 is for there being statistical significance.
2 experimental results, in Table 1
Table 1 embodiment of the present invention gained health product lipid-lowering effect
Figure BDA0000403493200000051
Figure BDA0000403493200000061
Note: with normal group comparison, *p<0.05; With model group comparison, *p<0.05.
By upper table gained, to compare with normal group, the TC of model group, TG content all significantly raise, and HDL-C content significantly reduces, and all has significant difference, shows high blood lipid model modeling success; The model group of comparing, rat TC, the TG of embodiment 1 intervention group, embodiment 2 intervention group, embodiment 3 intervention group, embodiment 4 intervention group and embodiment 5 intervention group all significantly reduces, and HDL-C content all significantly raises, and has significant difference.Show that gained health product of the present invention have the function of effective reduction blood fat.
Two, gained seedling grass health product blood sugar lowering experimental example of the present invention
1 data and method
1.1 experiment material
1.1.1 reagent chain phleomycin (STZ) ,Gou Bai U.S. Sigma company; The embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 gained health product.
1.1.2 laboratory animal SD rat is 126, and by Shanghai, western pul-Kai laboratory animal company limited provides, male and female dual-purpose, body weight 150g~250g.
1.2 experimental technique
1.2.1 modeling method
Rat fasting, can't help water 12-16h, the STZ solution (fresh preparation) being mixed with the sodium citrate buffer solution (cold preservation) of 0.1mol/L, PH4.2,1 the property injection in abdominal cavity, detects blood glucose in modeling after 7 days, and it is model success that random blood sugar value is greater than 11.1mmol/L.
1.2.2 grouping and administration
Get 126 of rats, be divided at random 7 groups, every group 18, be respectively normal group, model group, embodiment 1 intervention group, embodiment 2 intervention group, embodiment 3 intervention group, embodiment 4 intervention group, embodiment 5 intervention group, normal group is to normal rats gavaged distilled water 42mL/kg, and model group is on modeling rat basis, to gavage distilled water 42mL/kg, latter 5 groups to gavage respectively the embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 health product 42mg/kg.Above-mentioned intervention group is all on modeling rat basis, to give gained health product of the present invention.All animals administration every day 1 time, successive administration 3 weeks, after last administration, fasting 12h, adopts strong blood sugar monitoring instrument and test strips, through tail venous blood sampling, surveys fasting blood sugar.
1.3 date processing
Adopt SPSS16.0 statistical software to process.Testing each index determining result represents with Mean scholar SD.Between group, mean relatively adopts one factor analysis of variance and paired t-test, and P<0.05 is for there being statistical significance.
2 experimental results, in Table 2
Table 2 embodiment of the present invention gained health product blood sugar decreasing effect
Figure BDA0000403493200000071
Note: with normal group comparison, *p<0.05; With model group comparison, *p<0.05.
By upper table gained, to compare with normal group, the blood sugar level of model group significantly raises, and has significant difference, shows hyperglycemia model modeling success; The model group of comparing, the rat blood sugar level of embodiment 1 intervention group, embodiment 2 intervention group, embodiment 3 intervention group, embodiment 4 intervention group and embodiment 5 intervention group all significantly reduces, and has significant difference.Showing that gained health product of the present invention have effectively falls hypoglycemic function.

Claims (10)

1. seedling grass is being prepared blood fat reducing or/and the application in health-caring product capable of reducing blood sugar.
2. application according to claim 1, is characterized in that: described health product are tablet, effervescent tablet, capsule or oral liquid.
3. application according to claim 2, is characterized in that: described tablet is mainly made by the component of following weight portion: 100 parts of seedling grass, diluent 50-100 part, adhesive 2-10 part, disintegrating agent 0.5-5 part, lubricant 0.1-0.5 part.
4. application according to claim 3, is characterized in that: it is mainly to be made by following steps:
(1) seedling grass is cleaned, dewaters, is dried, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with diluent and disintegrating agent, sieve, obtain mixture;
(3) adhesive is dissolved with ethanol water, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is sieved granulation, dry, granulate;
(5) add lubricant, mix homogeneously, tabletting, obtains.
5. application according to claim 2, is characterized in that: described effervescent tablet is mainly made by the component of following weight portion: 100 parts of seedling grass, diluent 50-100 part, adhesive 2-10 part, sodium bicarbonate 0.1-0.5 part, citric acid 0.1-0.5 part, lubricant 0.05-0.1 part.
6. application according to claim 5, is characterized in that: it is mainly to be made by following steps:
(1) seedling grass is cleaned, dewaters, is dried, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with the sodium bicarbonate of diluent, 40-60% and the citric acid of 40-60%, sieve, obtain mixture;
(3) adhesive is dissolved with ethanol water, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is sieved granulation, dry, granulate;
(5) add sodium bicarbonate and the citric acid of lubricant, surplus, mix homogeneously, tabletting, obtains.
7. application according to claim 2, is characterized in that: described capsule is mainly made by the component of following weight portion: 100 parts of seedling grass, diluent 50-100 part, adhesive 2-10 part, disintegrating agent 0.5-5 part.
8. application according to claim 7, is characterized in that: it is mainly to be made by following steps:
(1) seedling grass is cleaned, dewaters, is dried, obtain dry seedling grass;
(2) dry seedling grass meal is broken, mix homogeneously with diluent and disintegrating agent, sieve, obtain mixture;
(3) adhesive is dissolved with ethanol water, join in said mixture, stir, obtain coarse grain;
(4) above-mentioned coarse grain is sieved granulation, dry, granulate, encapsulated, obtain.
9. application according to claim 2, is characterized in that: described oral liquid is mainly made by the component of following weight portion: 100 parts of seedling grass, sweeting agent 0.01-0.05 part, antiseptic 0.01-0.05 part, antioxidant 0.01-0.05 part.
10. application according to claim 9, is characterized in that: it is mainly to be made by following steps:
(1) seedling grass is added to pure water heating extraction, extracting solution is condensed into fluid extract;
(2) fluid extract thin up, adds sweeting agent, antiseptic and antioxidant, stirs, and being diluted to relative density is 1.04-1.08;
(3) fill, sterilizing, obtains.
CN201310517114.9A 2013-10-28 2013-10-28 Application of Medicagohispida Gaertn in preparation of hypolipemic and hpyerglycemic healthcare products Pending CN103610733A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104257728A (en) * 2014-09-18 2015-01-07 刘长喜 Application of cyperaceae bulbostylis barbata in preparing lipid-lowering drug and health product
CN104288364A (en) * 2014-09-18 2015-01-21 刘长喜 Application of guncus in preparation of medicines and health products for preventing and treating diabetes mellitus
CN105878340A (en) * 2016-05-04 2016-08-24 河南师范大学 Alfalfa effervescent tablets and preparation method thereof
CN105878367A (en) * 2016-05-04 2016-08-24 河南师范大学 Herba salviae plebeiae extract effervescent tablets and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张长铎: "《情系这片盐碱地 研究开发调整》", 31 March 2002, 气象出版社 *
朱恩俊等: "HACCP在秧草罐头制品生产中的应用", 《食品工程》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104257728A (en) * 2014-09-18 2015-01-07 刘长喜 Application of cyperaceae bulbostylis barbata in preparing lipid-lowering drug and health product
CN104288364A (en) * 2014-09-18 2015-01-21 刘长喜 Application of guncus in preparation of medicines and health products for preventing and treating diabetes mellitus
CN105878340A (en) * 2016-05-04 2016-08-24 河南师范大学 Alfalfa effervescent tablets and preparation method thereof
CN105878367A (en) * 2016-05-04 2016-08-24 河南师范大学 Herba salviae plebeiae extract effervescent tablets and preparation method thereof

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Application publication date: 20140305