CN105873609B - 葡萄球菌感染的被动免疫 - Google Patents

葡萄球菌感染的被动免疫 Download PDF

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CN105873609B
CN105873609B CN201480067873.2A CN201480067873A CN105873609B CN 105873609 B CN105873609 B CN 105873609B CN 201480067873 A CN201480067873 A CN 201480067873A CN 105873609 B CN105873609 B CN 105873609B
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antibody
amd
antibodies
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binding
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CN105873609A (zh
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J·L·戴斯
E·施瓦兹
J·J·瓦罗
J·布罗德尔
S·N·贝洛-伊里萨瑞
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University of Rochester
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/531—Production of immunochemical test materials
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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CN201480067873.2A 2013-12-13 2014-12-15 葡萄球菌感染的被动免疫 Active CN105873609B (zh)

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US201361915953P 2013-12-13 2013-12-13
US61/915,953 2013-12-13
PCT/US2014/070337 WO2015089502A2 (en) 2013-12-13 2014-12-15 Passive immunization for staphylococcus infections

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CN105873609A CN105873609A (zh) 2016-08-17
CN105873609B true CN105873609B (zh) 2021-06-25

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US (2) US10100127B2 (enExample)
EP (1) EP3079720B1 (enExample)
JP (2) JP6533226B2 (enExample)
KR (1) KR102318139B1 (enExample)
CN (1) CN105873609B (enExample)
AU (1) AU2014361821B2 (enExample)
BR (1) BR112016013514B1 (enExample)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3252076B1 (en) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostic use of antibodies against ror-1 protein
US10940204B2 (en) 2015-07-31 2021-03-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
EP3365027B1 (en) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu specific antibodies and their use in inhibiting biofilm
AU2018206560B9 (en) * 2017-01-04 2025-04-03 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
EP3600358A1 (en) * 2017-03-31 2020-02-05 Acell, Inc. Extracellular matrix compositions with bactericidal or bacteriostatic characteristics useful for protecting and treating patients with bacterial infections
CA3145385A1 (en) 2019-07-08 2021-01-14 Steven D. Goodman Antibody compositions for disrupting biofilms
CA3204730A1 (en) * 2021-01-15 2022-07-21 Gowrishankar MUTHUKRISHNAN Staphylococcus aureus antigen-based nucleic acid vaccines
EP4108197A1 (en) 2021-06-24 2022-12-28 Gradient Denervation Technologies Systems for treating tissue
CN119998318A (zh) * 2022-04-08 2025-05-13 D2M生物治疗有限公司 抗mica/b抗体及其用途
CN115925947B (zh) * 2022-09-27 2023-08-22 上海百英生物科技股份有限公司 一种亲和力成熟方法及抗人pd-l1单域抗体的亲和力成熟
WO2026145542A1 (zh) * 2024-12-30 2026-07-09 康源博创生物科技(北京)有限公司 一种多肽以及包含其的抗体
CN120425066B (zh) * 2025-05-06 2025-10-28 中国农业科学院北京畜牧兽医研究所 一种与羊种布鲁氏菌复方新诺明耐药性相关的分子标记及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979089A (zh) * 2010-11-17 2011-02-23 赤峰博恩药业有限公司 奶牛金黄色葡萄球菌乳房炎灭活疫苗及其制备方法
CN102890153A (zh) * 2012-05-24 2013-01-23 天津兰瑞生物技术有限公司 脂磷壁酸elisa检测试剂盒及其制备技术

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
US6596509B1 (en) 1998-07-10 2003-07-22 Cornell Research Foundation, Inc. Recombinant constructs and systems for secretion of proteins via type III secretion systems
FR2871237B1 (fr) 2004-06-08 2011-03-11 Abag Nouveaux polypeptides pour la mise en evidence in vitro et la prevention des infections staphylococciques sur protheses articulaires et autres materiels etrangers implantes
ES2730275T3 (es) 2004-09-22 2019-11-11 Glaxosmithkline Biologicals Sa Composición inmunógena para uso en vacunación contra estafilococos
DK2027155T3 (en) 2006-06-06 2016-05-09 Crucell Holland Bv HUMAN BINDING MOLECULES with killer activity against staphylococci and uses thereof
ZA200904022B (en) 2006-12-08 2010-08-25 Lexicon Pharmaceuticals Inc Monoclonal antibodies against ANGPTL3
US8101190B2 (en) 2009-03-03 2012-01-24 Ingen Biosciences Method for diagnosing staphylococcal infections
EP2419129A2 (en) 2009-04-14 2012-02-22 Novartis AG Compositions for immunising against staphylococcus aerus
US8580714B2 (en) 2009-10-14 2013-11-12 Janssen Biotech, Inc. Methods of affinity maturing antibodies
EP2566891B1 (en) * 2010-05-03 2016-11-02 University Of Rochester Anti-glucosaminidase passive immunization for staphylococcus aureus infections
CA2853943C (en) 2011-11-02 2015-12-08 University Of Rochester Anti-glucosaminidase passive immunization for staphylococcus aureus infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979089A (zh) * 2010-11-17 2011-02-23 赤峰博恩药业有限公司 奶牛金黄色葡萄球菌乳房炎灭活疫苗及其制备方法
CN102890153A (zh) * 2012-05-24 2013-01-23 天津兰瑞生物技术有限公司 脂磷壁酸elisa检测试剂盒及其制备技术

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Localized Perforation of thLysis of Staphylococcus aureuse Cell Wall by a Major Autolysin: atl Gene Products and the Onset of Penicillin-Induced;MOTOYUKI SUGAI等;《JOURNAL OF BACTERIOLOGY,》;19970531;第179卷(第9期);2958-2962页 *

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