CN1058709C - 治疗用酰胺类化合物 - Google Patents
治疗用酰胺类化合物 Download PDFInfo
- Publication number
- CN1058709C CN1058709C CN96108113A CN96108113A CN1058709C CN 1058709 C CN1058709 C CN 1058709C CN 96108113 A CN96108113 A CN 96108113A CN 96108113 A CN96108113 A CN 96108113A CN 1058709 C CN1058709 C CN 1058709C
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- China
- Prior art keywords
- trifluoromethyl
- xenyl
- carboxylic acid
- acid amides
- acid
- Prior art date
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- -1 Amide compounds Chemical class 0.000 title claims description 102
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 201000001320 Atherosclerosis Diseases 0.000 claims abstract description 12
- 102000018616 Apolipoproteins B Human genes 0.000 claims abstract description 10
- 108010027006 Apolipoproteins B Proteins 0.000 claims abstract description 10
- 230000028327 secretion Effects 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 7
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- 150000003839 salts Chemical class 0.000 claims description 28
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- 125000005605 benzo group Chemical group 0.000 claims description 13
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- 238000006243 chemical reaction Methods 0.000 description 32
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB1995/000448 WO1996040640A1 (en) | 1995-06-07 | 1995-06-07 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
| WOPCT/IB95/00448 | 1995-06-07 | ||
| CA002223574A CA2223574C (en) | 1995-06-07 | 1995-06-07 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein b (apo b) secretion |
| HU9601566A HUP9601566A3 (en) | 1995-06-07 | 1996-06-06 | Therapeutic tetrahydro-isoquinolin derivatives, their intermediates and pharmaceutical compositions containing the active component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1141918A CN1141918A (zh) | 1997-02-05 |
| CN1058709C true CN1058709C (zh) | 2000-11-22 |
Family
ID=89994039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96108113A Expired - Fee Related CN1058709C (zh) | 1995-06-07 | 1996-06-07 | 治疗用酰胺类化合物 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1058709C (no) |
| NO (1) | NO307826B1 (no) |
| SK (1) | SK283408B6 (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2654B1 (en) * | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2390B1 (en) * | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
| CN113248427B (zh) * | 2021-06-01 | 2023-05-02 | 苏州大学 | 磺酰胺基烟酸衍生物、酰胺基烟酸衍生物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0106140A2 (en) * | 1982-09-10 | 1984-04-25 | The Wellcome Foundation Limited | Benzoic acid derivatives |
| EP0643057A1 (en) * | 1993-09-03 | 1995-03-15 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein |
-
1995
- 1995-06-07 SK SK726-96A patent/SK283408B6/sk unknown
-
1996
- 1996-06-06 NO NO962385A patent/NO307826B1/no not_active IP Right Cessation
- 1996-06-07 CN CN96108113A patent/CN1058709C/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0106140A2 (en) * | 1982-09-10 | 1984-04-25 | The Wellcome Foundation Limited | Benzoic acid derivatives |
| EP0643057A1 (en) * | 1993-09-03 | 1995-03-15 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein |
Also Published As
| Publication number | Publication date |
|---|---|
| SK72696A3 (en) | 1997-11-05 |
| SK283408B6 (sk) | 2003-07-01 |
| CN1141918A (zh) | 1997-02-05 |
| NO962385L (no) | 1996-12-09 |
| NO962385D0 (no) | 1996-06-06 |
| NO307826B1 (no) | 2000-06-05 |
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